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Greatist</h3><ul><li><a class="css-q7lbnd" href="https://greatist.com/about/about-us">Who We Are</a></li><li><a class="css-q7lbnd" href="https://greatist.com/health/process">Our Editorial Process</a></li><li><a class="css-q7lbnd" href="https://greatist.com/about/product-selection-process">Our Product Vetting Process</a></li><li><a class="css-q7lbnd" href="https://greatist.com/about/content-integrity">Content Integrity</a></li><li><a class="css-q7lbnd" href="https://greatist.com/about/medical-team">Conscious Language</a></li></ul></div></div></li></ul></div><div class="css-12qvns3"></div><div class="css-2dofw9"></div></div></div></div><div class="css-ifmqwy"></div></div><div class="css-4a7tih"><aside class="css-1wm8u43" data-testid="header-leaderboard" data-sticky="true"><div data-empty="true" class="css-1j2d96m"><div class="css-1hjaa0k"><span class="css-zya54r"></span></div><div id="dlb1__slot" data-adbridg-ad-class="dlb1" data-ad="true" class="css-1jpwf16"></div></div></aside></div><aside data-testid="mobile-leaderboard" class="css-pdceuf"><div class="css-11egx89"><button class="icon-hl-close-thick css-1pyovmj"></button><div data-empty="true" class="css-1fteite"><div class="css-1hjaa0k"><span class="css-zya54r"></span></div><div id="mlb1__slot" data-adbridg-ad-class="mlb1" data-ad="true" class="css-bcus5s"></div></div></div></aside><div data-placement="subheader"></div><div><div class="css-m260rd"><div data-article-body="0" class="css-1h1rean css-1iltj1i"><div class="css-z468a2"><h1>GLP-1 for Weight Loss: How Does It Work?</h1><div data-preamp="social-proof-lessons"></div><div data-testid="byline"><section data-testid="byline" class="css-1x96gnc"><div class="css-1q67gt9"><div class="css-xc63cd"><img src="//i0.wp.com/post.greatist.com/wp-content/uploads/2022/09/Philip-Ngo-Headshot_500x500-Bio.png?w=105&h=105" alt=""/></div></div><div><span><span>Medically reviewed by <a class="css-q7lbnd css-bmt0mt" href="https://greatist.com/reviewers/philip-ngo-pharmd">Philip Ngo, PharmD</a></span></span> — <span><span><span><span>Written by <a class="css-q7lbnd css-bmt0mt" href="https://greatist.com/authors/alysa-hullett">Alysa Hullett</a></span></span></span></span> <span> on November 2, 2023</span></div></section></div><div><article class="article-body css-d2znx6 undefined"><div data-testid="tabbed-article-section" class="css-12va8w7"><span style="font-size:0;line-height:0"></span><div></div><span style="font-size:0;line-height:0"></span><div><div><p class="css-1rj5f61">GLP-1 receptor medications mimic the body’s natural GLP-1 hormone, making you feel full.</p></div></div><div><p>Anything that seems like a quick n’ easy <a rel="noreferrer noopener" href="https://greatist.com/health/weight-loss-in-your-30s" target="_blank" class="content-link css-q7lbnd">weight loss</a> cure tends to fly off the shelves, and GLP-1 drugs (<a rel="noreferrer noopener" href="https://greatist.com/health/how-to-get-ozempic-for-weight-loss" target="_blank" class="content-link css-q7lbnd">Ozempic</a>, Wegovy, Rybelsus) are no exception. But is semaglutide actually worth the hype?</p></div><div><div data-preamp="serena-chatbot"></div></div><div><p>Let’s explore the ins and outs of GLP-1 for weight loss, including a deep dive into how (and if) it works.</p></div><div class="css-20w1gi"><aside class="css-0 css-0" data-testid="sticky-inline-ad" data-sticky="false"><div><div data-empty="true" class="css-1sq15os"><div class="css-1hjaa0k"><span class="css-zya54r"></span></div><div id="inline2__slot" data-adbridg-ad-class="inline2__slot" data-ad="true" class="css-1t05dkn"></div></div></div></aside></div></div><div data-testid="tabbed-article-section" class="css-1avyp1d"><span style="font-size:0;line-height:0"></span><h2><div><a class="chartbeat-section" name="What-is-GLP-1-for-weight-loss">What <strong>is GLP 1 for weight loss?</strong></a></div></h2><span style="font-size:0;line-height:0"></span><div><p>GLP-1 <a rel="noopener noreferrer" href="https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/medications-containing-semaglutide-marketed-type-2-diabetes-or-weight-loss" target="_blank" class="content-link css-q7lbnd">causes</a> your body to produce more <a rel="noreferrer noopener" href="https://greatist.com/health/how-to-lower-insulin" target="_blank" class="content-link css-q7lbnd">insulin</a>, reducing blood sugar levels. In high quantities, it also triggers the parts of your brain that reduce appetite and make you feel full — even when you haven’t eaten anything.</p></div><div><p>In a <a rel="noopener noreferrer" href="https://www.nejm.org/doi/10.1056/NEJMoa2032183" target="_blank" class="content-link css-q7lbnd">2021 study</a> of 2,000 adults with obesity, researchers compared two groups: People who dieted and exercised while taking semaglutide and those who dieted and exercised without taking it.</p></div><div><p>Researchers found that after 68 weeks, about half the participants taking the drug lost about 15 percent of their weight. A third lost 20 percent. Those who only dieted and <a rel="noreferrer noopener" href="https://greatist.com/fitness/how-to-start-exercising-again" target="_blank" class="content-link css-q7lbnd">exercised</a> alone lost about 2.4 percent of their weight.</p></div><div><p>The Food and Drug Administration (FDA) has only approved three semaglutide medications thus far. They are:</p></div><div><ul><li><strong>Ozempic</strong> is <a rel="noreferrer noopener" href="https://greatist.com/health/ozempic-for-weight-loss" target="_blank" class="content-link css-q7lbnd">only approved</a> to lower blood sugar and reduce the risk of heart problems in adults with type 2 <a rel="noreferrer noopener" href="https://greatist.com/health/long-term-effects-diabetes" target="_blank" class="content-link css-q7lbnd">diabetes</a> mellitus.</li><li><strong>Rybelsus tablets</strong> are approved for the same use as Ozempic, only in oral form.</li><li><strong>Wegovy injections</strong> are approved for adults and children over 12 who are medically considered either overweight with weight-related medical problems or obese.</li></ul></div><div><p>All of these medications require a prescription, and there’s also no FDA-approved generic version.</p></div><span class="css-zya54r"></span></div><div data-testid="tabbed-article-section" class="css-1avyp1d"><span style="font-size:0;line-height:0"></span><h2><div><a class="chartbeat-section" name="Which-GLP-1-is-best-for-weight-loss"><strong>Which GLP-1 is best for weight loss?</strong></a></div></h2><span style="font-size:0;line-height:0"></span><div><p>You may see TikTokers injecting or popping it on the reg, but the only GLP-1 medication approved for weight loss is <strong>Wegovy</strong>. Still, it’s not meant for those who want to drop a few pounds — technically, it’s <a rel="noopener noreferrer" href="https://www.fda.gov/news-events/press-announcements/fda-approves-new-drug-treatment-chronic-weight-management-first-2014" target="_blank" class="content-link css-q7lbnd">only approved for</a>:</p></div><div><ul><li>those with a <a href="https://greatist.com/health/bmi-for-women" target="_blank" rel="noreferrer noopener" class="content-link css-q7lbnd">BMI</a> of 30 or more</li><li>those with a BMI greater than 27 + who also have at least one weight-related health condition</li></ul></div><div><p>Many people have been taking Ozempic and other GLP-1 formulations off-label to lose weight, even if they don’t have a medically-recognized issue. But remember that this caused a <a href="https://www.fda.gov/drugs/drug-safety-and-availability/drug-shortages" target="_blank" rel="noopener noreferrer" class="content-link css-q7lbnd">serious shortage</a> for those who really needed it.</p></div><div><div id="widget_call_out_7aa29a11-1296-4c88-a26a-4b7c6ada0850" class="css-x626uz"><span style="font-size:0;line-height:0"></span><div class="css-1si3c39"><div class="css-xqvouu"><h3 class="css-ztyhkg"><div><span class="css-98kufj">Safety first!</span></div></h3><div class="css-orfj9x"><p>Not all “semaglutide” products are legit. Most of these sketchy formulas — like semaglutide sodium or semaglutide acetate — <a rel="noopener noreferrer" href="https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/medications-containing-semaglutide-marketed-type-2-diabetes-or-weight-loss" target="_blank" class="content-link css-q7lbnd">haven’t been found</a> to be effective or safe yet.</p><p>If you opt for an online pharmacy, the FDA’s <a rel="noopener noreferrer" href="https://www.fda.gov/drugs/quick-tips-buying-medicines-over-internet/besaferx-your-source-online-pharmacy-information" target="_blank" class="content-link css-q7lbnd">BeSafeRx</a> campaign has resources to help you make a smart choice. Also, talk to your healthcare provider before trying any weight loss aid, even if a product seems safe.</p></div></div></div><div class="css-1uwjw6e"><div></div><div></div></div></div></div><div class="css-20w1gi"><aside class="css-0 css-0" data-testid="sticky-inline-ad" data-sticky="false"><div><div data-empty="true" class="css-1sq15os"><div class="css-1hjaa0k"><span class="css-zya54r"></span></div><div id="inline7__slot" data-adbridg-ad-class="inline7__slot" data-ad="true" class="css-1t05dkn"></div></div></div></aside></div></div><div data-testid="tabbed-article-section" class="css-1avyp1d"><span style="font-size:0;line-height:0"></span><h2><div><a class="chartbeat-section" name="Takeaway"><strong>Takeaway</strong></a></div></h2><span style="font-size:0;line-height:0"></span><div><p>GLP-1 drugs work by essentially imitating the body’s natural GLP-1 hormone, which is emitted after you eat and contributes to feelings of fullness. It also reduces blood sugar levels.</p></div><div><p>So far, these medications are only approved for those with type 2 diabetes, those with obesity, or those who are <a rel="noreferrer noopener" href="https://greatist.com/health/how-much-should-i-weigh" target="_blank" class="content-link css-q7lbnd">overweight</a> with at least one medically-recognized weight condition.</p></div><div><p>Since it’s only available by prescription at the moment, talk to your doctor about if GLP-1 is legit for you.</p></div></div></article><span class="css-zya54r"></span></div><p data-testid="last-medically-reviewed" class="css-1kir5of"><span> </span></p><div><div class="css-16supv1 css-1dee91x"><div class="css-uewl2b"><div aria-expanded="false" aria-controls="article-resources" class="css-1dqtdbb" role="button"><p class="css-12jvsp7"><span class="css-1p6d3md icon-hlvideo-minus"></span><span class="css-1p6d3md icon-hlvideo-plus"></span> <span class="css-r1885">8 sources</span><span class="sro">collapsed</span></p></div><div id="article-resources" role="region" class="css-1ugaz02"><ul class="css-va52x2"><li class="css-1ivygmc"><cite><span>BeSafeRx. (2020).</span><br/><a class="css-q7lbnd css-1ivue52" target="_blank" rel="noopener noreferrer" href="https://www.fda.gov/drugs/quick-tips-buying-medicines-over-internet/besaferx-your-source-online-pharmacy-information">https://www.fda.gov/drugs/quick-tips-buying-medicines-over-internet/besaferx-your-source-online-pharmacy-information</a></cite></li><li class="css-1ivygmc"><cite><span>Collins L, et al. (2023). Glucagon-like peptide-1 receptor agonists.</span><br/><a class="css-q7lbnd css-1ivue52" target="_blank" rel="noopener noreferrer" href="https://www.ncbi.nlm.nih.gov/books/NBK551568">https://www.ncbi.nlm.nih.gov/books/NBK551568</a></cite></li><li class="css-1ivygmc"><cite><span>Drug shortages. (2023).</span><br/><a class="css-q7lbnd css-1ivue52" target="_blank" rel="noopener noreferrer" href="https://www.fda.gov/drugs/drug-safety-and-availability/drug-shortages">https://www.fda.gov/drugs/drug-safety-and-availability/drug-shortages</a></cite></li><li class="css-1ivygmc"><cite><span>FDA approves new drug treatment for chronic weight management, first since 2014. (2021).</span><br/><a class="css-q7lbnd css-1ivue52" target="_blank" rel="noopener noreferrer" href="https://www.fda.gov/news-events/press-announcements/fda-approves-new-drug-treatment-chronic-weight-management-first-2014">https://www.fda.gov/news-events/press-announcements/fda-approves-new-drug-treatment-chronic-weight-management-first-2014</a></cite></li><li class="css-1ivygmc"><cite><span>Jensterle, M, et al. (2022). Efficacy of GLP-1 RA approved or weight management in patients with or without diabetes.</span><br/><a class="css-q7lbnd css-1ivue52" target="_blank" rel="noopener noreferrer" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063254">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063254</a></cite></li><li class="css-1ivygmc"><cite><span>Mahapatra MK, et al. (2022). Semaglutide, a glucagon like peptide-1 receptor agonist with cardiovascular benefits for management of type 2 diabetes.</span><br/><a class="css-q7lbnd css-1ivue52" target="_blank" rel="noopener noreferrer" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8736331">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8736331</a></cite></li><li class="css-1ivygmc"><cite><span>Medications containing semaglutide marketed for type 2 diabetes or weight loss. (2023).</span><br/><a class="css-q7lbnd css-1ivue52" target="_blank" rel="noopener noreferrer" href="https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/medications-containing-semaglutide-marketed-type-2-diabetes-or-weight-loss">https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/medications-containing-semaglutide-marketed-type-2-diabetes-or-weight-loss</a></cite></li><li class="css-1ivygmc"><cite><span>Wilding, JPH, et al. (2021). Once-weekly semaglutide in adults with overweight or obesity.</span><br/><a class="css-q7lbnd css-1ivue52" target="_blank" rel="noopener noreferrer" href="https://www.nejm.org/doi/10.1056/NEJMoa2032183">https://www.nejm.org/doi/10.1056/NEJMoa2032183</a></cite></li></ul></div></div><div class="css-i94p2o"><div class="css-hnd0c4"><a class="css-fh1b22">FEEDBACK:</a><a class="css-1olys1n icon icon-hl-frown"></a><a class="css-1olys1n icon icon-hl-smile"></a></div></div><div class="css-17pa3jd"><div class="css-1wfhjx3"><div class="button-wrapper facebook"><a class="css-1olys1n facebook button icon icon-hl-facebook" href="https://www.facebook.com/sharer/sharer.php?u=https%3A%2F%2Fgreatist.com%2Fhealth%2Fglp-1-for-weight-loss%3Futm_medium%3Dsocial%26utm_source%3Dfacebook%26utm_campaign%3Dsocial-sharebar-referred-desktop" rel="noopener noreferrer nofollow" target="_blank" title="Share on Facebook"></a></div><div class="button-wrapper twitter"><a class="css-1olys1n twitter button icon 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Need(le) to Know Facts|rn6" href="https://greatist.com/health/ozempic-face?utm_source=ReadNext" aria-label="image-link" data-ga4="Read Next button clicks" data-testid="image-link" aria-hidden="true" tabindex="-1"><div class="css-79elbk"><span class="css-rwmw5v css-1pf0x3y"><span class="css-1767n2d"><lazy-image alt="What Is Ozempic Face? 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Need(le) to Know Facts|rn6" href="https://greatist.com/health/ozempic-face?utm_source=ReadNext" data-ga4="Read Next button clicks">READ MORE<span class="icon-hl-arrow-right css-1bisyf5"></span></a></div></div></div><section class="css-17lceqi css-1ub4i5m"></section></div></div></li><li class="css-1agfdnn"><div class="css-m260rd"><div class="css-1h1rean"><div class="css-z468a2 css-qdpzos"><div class="css-k3xa71"><span style="font-size:0;line-height:0"></span><figure class="css-1pvwan1"><a class="css-1olys1n" data-event="engagement|bottom page content promo click|/health/how-to-ask-your-doctor-for-weight-loss-pills;engagement|bottom page content promo click index|8" data-element-event="INTERNAL LINK|FOOTER|Any Page|Read This Next|LINK|How to Ask Your Doctor for Weight Loss Pills: Tips for Success|rn7" href="https://greatist.com/health/how-to-ask-your-doctor-for-weight-loss-pills?utm_source=ReadNext" aria-label="image-link" data-ga4="Read Next button clicks" data-testid="image-link" aria-hidden="true" tabindex="-1"><div class="css-79elbk"><span class="css-rwmw5v css-1pf0x3y"><span class="css-1767n2d"><lazy-image alt="How to Ask Your Doctor for Weight Loss Pills: Tips for Success" src="https://media.post.rvohealth.io/wp-content/uploads/sites/2/2023/10/629610-Ozempic-How-to-Ask-Your-Doctor-for-Weight-Loss-Pills-732x549-thumbnail-732x549.jpg" srcSet="https://media.post.rvohealth.io/wp-content/uploads/sites/2/2023/10/629610-Ozempic-How-to-Ask-Your-Doctor-for-Weight-Loss-Pills-732x549-thumbnail-732x549.jpg 200w" className="css-1lyqwde"></lazy-image></span></span><span class="css-1fb1nmp"><span class="css-a10gts"></span></span></div></a></figure><div class="css-u8uhak"><a class="css-1olys1n css-zl3uk8" data-event="engagement|bottom page content promo click|/health/how-to-ask-your-doctor-for-weight-loss-pills;engagement|bottom page content promo click index|8" data-element-event="INTERNAL LINK|FOOTER|Any Page|Read This Next|LINK|How to Ask Your Doctor for Weight Loss Pills: Tips for Success|rn7" href="https://greatist.com/health/how-to-ask-your-doctor-for-weight-loss-pills?utm_source=ReadNext" data-testid="title-link" data-ga4="Read Next button clicks">How to Ask Your Doctor for Weight Loss Pills: Tips for Success</a><p><a class="css-2fdibo css-v34bze" data-event="engagement|bottom page content promo click|/health/how-to-ask-your-doctor-for-weight-loss-pills;engagement|bottom page content promo click index|8" data-element-event="INTERNAL LINK|FOOTER|Any Page|Read This Next|LINK|How to Ask Your Doctor for Weight Loss Pills: Tips for Success|rn7" href="https://greatist.com/health/how-to-ask-your-doctor-for-weight-loss-pills?utm_source=ReadNext" data-testid="text-link" data-ga4="Read Next button clicks" aria-hidden="true" tabindex="-1">Learn how to ask your doctor for weight loss pills confidently. Get tips on discussing options, BMI criteria, and medication pros and cons.</a></p><a class="css-q7lbnd css-1sgs9s5" data-event="engagement|bottom page content promo click|/health/how-to-ask-your-doctor-for-weight-loss-pills;engagement|bottom page content promo click index|8" data-element-event="INTERNAL LINK|FOOTER|Any Page|Read This Next|LINK|How to Ask Your Doctor for Weight Loss Pills: Tips for Success|rn7" href="https://greatist.com/health/how-to-ask-your-doctor-for-weight-loss-pills?utm_source=ReadNext" data-ga4="Read Next button clicks">READ MORE<span class="icon-hl-arrow-right css-1bisyf5"></span></a></div></div></div><section class="css-17lceqi css-1ub4i5m"></section></div></div></li><li class="css-1agfdnn"><div class="css-m260rd"><div class="css-1h1rean"><div class="css-z468a2 css-qdpzos"><div class="css-k3xa71"><span style="font-size:0;line-height:0"></span><figure class="css-1pvwan1"><a class="css-1olys1n" data-event="engagement|bottom page content promo click|/health/how-to-get-ozempic-for-weight-loss;engagement|bottom page content promo click index|9" data-element-event="INTERNAL LINK|FOOTER|Any Page|Read This Next|LINK|How to Get Ozempic Prescriptions Safely and Ethically|rn8" href="https://greatist.com/health/how-to-get-ozempic-for-weight-loss?utm_source=ReadNext" aria-label="image-link" data-ga4="Read Next button clicks" data-testid="image-link" aria-hidden="true" tabindex="-1"><div class="css-79elbk"><span class="css-rwmw5v css-1pf0x3y"><span class="css-1767n2d"><lazy-image alt="How to Get Ozempic Prescriptions Safely and Ethically" src="https://media.post.rvohealth.io/wp-content/uploads/sites/2/2024/03/189594-grt-Do-I-Need-Therapy-732x549-Feature.jpg" srcSet="https://media.post.rvohealth.io/wp-content/uploads/sites/2/2024/03/189594-grt-Do-I-Need-Therapy-732x549-Feature.jpg 200w" className="css-1lyqwde"></lazy-image></span></span><span class="css-1fb1nmp"><span class="css-a10gts"></span></span></div></a></figure><div class="css-u8uhak"><a class="css-1olys1n css-zl3uk8" data-event="engagement|bottom page content promo click|/health/how-to-get-ozempic-for-weight-loss;engagement|bottom page content promo click index|9" data-element-event="INTERNAL LINK|FOOTER|Any Page|Read This Next|LINK|How to Get Ozempic Prescriptions Safely and Ethically|rn8" href="https://greatist.com/health/how-to-get-ozempic-for-weight-loss?utm_source=ReadNext" data-testid="title-link" data-ga4="Read Next button clicks">How to Get Ozempic Prescriptions Safely and Ethically</a><p><a class="css-2fdibo css-v34bze" data-event="engagement|bottom page content promo click|/health/how-to-get-ozempic-for-weight-loss;engagement|bottom page content promo click index|9" data-element-event="INTERNAL LINK|FOOTER|Any Page|Read This Next|LINK|How to Get Ozempic Prescriptions Safely and Ethically|rn8" href="https://greatist.com/health/how-to-get-ozempic-for-weight-loss?utm_source=ReadNext" data-testid="text-link" data-ga4="Read Next button clicks" aria-hidden="true" tabindex="-1">Discover safe ways to use Ozempic for weight loss. 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He is passionate about educating others on medication use and currently practices in Houston, Texas. \u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eEducation\u003c/strong\u003e\u003c/p\u003e\n\u003cul\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe University of Texas at Austin, BSA\u003c/span\u003e\u003c/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eUniversity of Houston, PharmD\u003c/span\u003e\u003c/li\u003e\n\u003c/ul\u003e\n\u003cp\u003e\u003cstrong\u003eCertifications\u003c/strong\u003e\u003c/p\u003e\n\u003cul\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eLicensed Pharmacist\u003c/span\u003e\u003c/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eHeartsaver First Aid CPR AED (American Heart Association)\u003c/span\u003e\u003c/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eCertified Immunizer\u003c/span\u003e\u003c/li\u003e\n\u003c/ul\u003e\n"},"avatar":{"title":"","width":500,"height":500,"src":"https://post.greatist.com/wp-content/uploads/2022/09/Philip-Ngo-Headshot_500x500-Bio.png"},"bioBlurb":{"nodes":["Dr. Philip Ngo is a pharmacist with over a decade of experience in community pharmacy. His interests lie in drug information, disease state management, and…"]}}],"editors":[{"role":"Editor","name":{"display":"Lianna Bass"}}],"pinterestImage":{"path":"https://media.post.rvohealth.io/wp-content/uploads/sites/2/2023/03/GRT-ozempic-732x549-thumb.jpg"},"hideFeedback":false,"isMedicare":false,"isBlog":false,"publishSource":"wordpress","isAmpSupported":false,"categories":[{"name":"Health","slug":"health","link":"/health","primary":true,"children":[]}],"language":{"en":"https://greatist.com/health/glp-1-for-weight-loss/","x-default":"https://greatist.com/health/glp-1-for-weight-loss/","current":"en"},"lang":"en","links":[],"colorScheme":"default","isContentSeries":false,"brandCTAs":[],"clusterNavLinks":[],"clusterUrls":[],"clusterLinks":{},"pathingTilesData":{},"pathingCardsData":{},"inArticlePathingCardsData":[],"quantitativeTrustData":{},"isPrependRecipeH2":false,"recipes":[],"breadcrumbsV2":[],"hideTabs":true,"tabs":[{"id":"_noHeaderPrefixedContent","title":null,"header":null,"body":[{"tagName":"div","source":"\u003cp class=\"css-1rj5f61\"\u003eGLP-1 receptor medications mimic the body’s natural GLP-1 hormone, making you feel full.\u003c/p\u003e"},{"tagName":"p","source":"Anything that seems like a quick n’ easy \u003ca rel=\"noreferrer noopener\" href=\"https://greatist.com/health/weight-loss-in-your-30s\" target=\"_blank\" class=\"content-link css-q7lbnd\"\u003eweight loss\u003c/a\u003e cure tends to fly off the shelves, and GLP-1 drugs (\u003ca rel=\"noreferrer noopener\" href=\"https://greatist.com/health/how-to-get-ozempic-for-weight-loss\" target=\"_blank\" class=\"content-link css-q7lbnd\"\u003eOzempic\u003c/a\u003e, Wegovy, Rybelsus) are no exception. But is semaglutide actually worth the hype?"},{"tagName":"div","attributes":{"data-preamp":"serena-chatbot"},"source":""},{"tagName":"p","source":"Let’s explore the ins and outs of GLP-1 for weight loss, including a deep dive into how (and if) it works."}]},{"id":"What-is-GLP-1-for-weight-loss","isCollapsable":false,"header":["What ",{"tagName":"strong","source":"is GLP 1 for weight loss?"}],"body":[{"tagName":"p","source":"GLP-1 \u003ca rel=\"noopener noreferrer\" href=\"https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/medications-containing-semaglutide-marketed-type-2-diabetes-or-weight-loss\" target=\"_blank\" class=\"content-link css-q7lbnd\"\u003ecauses\u003c/a\u003e your body to produce more \u003ca rel=\"noreferrer noopener\" href=\"https://greatist.com/health/how-to-lower-insulin\" target=\"_blank\" class=\"content-link css-q7lbnd\"\u003einsulin\u003c/a\u003e, reducing blood sugar levels. In high quantities, it also triggers the parts of your brain that reduce appetite and make you feel full — even when you haven’t eaten anything."},{"tagName":"p","source":"In a \u003ca rel=\"noopener noreferrer\" href=\"https://www.nejm.org/doi/10.1056/NEJMoa2032183\" target=\"_blank\" class=\"content-link css-q7lbnd\"\u003e2021 study\u003c/a\u003e of 2,000 adults with obesity, researchers compared two groups: People who dieted and exercised while taking semaglutide and those who dieted and exercised without taking it."},{"tagName":"p","source":"Researchers found that after 68 weeks, about half the participants taking the drug lost about 15 percent of their weight. A third lost 20 percent. Those who only dieted and \u003ca rel=\"noreferrer noopener\" href=\"https://greatist.com/fitness/how-to-start-exercising-again\" target=\"_blank\" class=\"content-link css-q7lbnd\"\u003eexercised\u003c/a\u003e alone lost about 2.4 percent of their weight."},{"tagName":"p","source":"The Food and Drug Administration (FDA) has only approved three semaglutide medications thus far. They are:"},{"tagName":"ul","source":"\u003cli\u003e\u003cstrong\u003eOzempic\u003c/strong\u003e is \u003ca rel=\"noreferrer noopener\" href=\"https://greatist.com/health/ozempic-for-weight-loss\" target=\"_blank\" class=\"content-link css-q7lbnd\"\u003eonly approved\u003c/a\u003e to lower blood sugar and reduce the risk of heart problems in adults with type 2 \u003ca rel=\"noreferrer noopener\" href=\"https://greatist.com/health/long-term-effects-diabetes\" target=\"_blank\" class=\"content-link css-q7lbnd\"\u003ediabetes\u003c/a\u003e mellitus.\u003c/li\u003e\u003cli\u003e\u003cstrong\u003eRybelsus tablets\u003c/strong\u003e are approved for the same use as Ozempic, only in oral form.\u003c/li\u003e\u003cli\u003e\u003cstrong\u003eWegovy injections\u003c/strong\u003e are approved for adults and children over 12 who are medically considered either overweight with weight-related medical problems or obese.\u003c/li\u003e"},{"tagName":"p","source":"All of these medications require a prescription, and there’s also no FDA-approved generic version."}]},{"id":"Which-GLP-1-is-best-for-weight-loss","isCollapsable":false,"header":[{"tagName":"strong","source":"Which GLP-1 is best for weight loss?"}],"body":[{"tagName":"p","source":"You may see TikTokers injecting or popping it on the reg, but the only GLP-1 medication approved for weight loss is \u003cstrong\u003eWegovy\u003c/strong\u003e. Still, it’s not meant for those who want to drop a few pounds — technically, it’s \u003ca rel=\"noopener noreferrer\" href=\"https://www.fda.gov/news-events/press-announcements/fda-approves-new-drug-treatment-chronic-weight-management-first-2014\" target=\"_blank\" class=\"content-link css-q7lbnd\"\u003eonly approved for\u003c/a\u003e:"},{"tagName":"ul","source":"\u003cli\u003ethose with a \u003ca href=\"https://greatist.com/health/bmi-for-women\" target=\"_blank\" rel=\"noreferrer noopener\" class=\"content-link css-q7lbnd\"\u003eBMI\u003c/a\u003e of 30 or more\u003c/li\u003e\u003cli\u003ethose with a BMI greater than 27 + who also have at least one weight-related health condition\u003c/li\u003e"},{"tagName":"p","source":"Many people have been taking Ozempic and other GLP-1 formulations off-label to lose weight, even if they don’t have a medically-recognized issue. But remember that this caused a \u003ca href=\"https://www.fda.gov/drugs/drug-safety-and-availability/drug-shortages\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"content-link css-q7lbnd\"\u003eserious shortage\u003c/a\u003e for those who really needed it."},{"widget":{"widgetFormat":"widget-call-out","items":[{"headerTitle":["Safety first!"],"content":[{"tagName":"p","source":"Not all “semaglutide” products are legit. Most of these sketchy formulas — like semaglutide sodium or semaglutide acetate — \u003ca rel=\"noopener noreferrer\" href=\"https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/medications-containing-semaglutide-marketed-type-2-diabetes-or-weight-loss\" target=\"_blank\" class=\"content-link css-q7lbnd\"\u003ehaven’t been found\u003c/a\u003e to be effective or safe yet."},{"tagName":"p","source":"If you opt for an online pharmacy, the FDA’s \u003ca rel=\"noopener noreferrer\" href=\"https://www.fda.gov/drugs/quick-tips-buying-medicines-over-internet/besaferx-your-source-online-pharmacy-information\" target=\"_blank\" class=\"content-link css-q7lbnd\"\u003eBeSafeRx\u003c/a\u003e campaign has resources to help you make a smart choice. Also, talk to your healthcare provider before trying any weight loss aid, even if a product seems safe."}]}]},"brandPage":{}}]},{"id":"Takeaway","isCollapsable":false,"header":[{"tagName":"strong","source":"Takeaway"}],"body":[{"tagName":"p","source":"GLP-1 drugs work by essentially imitating the body’s natural GLP-1 hormone, which is emitted after you eat and contributes to feelings of fullness. It also reduces blood sugar levels."},{"tagName":"p","source":"So far, these medications are only approved for those with type 2 diabetes, those with obesity, or those who are \u003ca rel=\"noreferrer noopener\" href=\"https://greatist.com/health/how-much-should-i-weigh\" target=\"_blank\" class=\"content-link css-q7lbnd\"\u003eoverweight\u003c/a\u003e with at least one medically-recognized weight condition."},{"tagName":"p","source":"Since it’s only available by prescription at the moment, talk to your doctor about if GLP-1 is legit for you."}]}],"hasAffiliateLinks":false,"affiliates":[],"isDisclaimer":false,"isOwnedAndOperatedPresent":false,"propsFor":{"articleResources":[{"displayLink":"fda.gov/drugs/quick-tips-buying-medicines-over-internet/besaferx-your-source-online-pharmacy-information","link":"https://www.fda.gov/drugs/quick-tips-buying-medicines-over-internet/besaferx-your-source-online-pharmacy-information","title":{"tagName":"span","source":"BeSafeRx. (2020)."}},{"displayLink":"ncbi.nlm.nih.gov/books/NBK551568","link":"https://www.ncbi.nlm.nih.gov/books/NBK551568","title":{"tagName":"span","source":"Collins L, et al. (2023). Glucagon-like peptide-1 receptor agonists."}},{"displayLink":"fda.gov/drugs/drug-safety-and-availability/drug-shortages","link":"https://www.fda.gov/drugs/drug-safety-and-availability/drug-shortages","title":{"tagName":"span","source":"Drug shortages. (2023)."}},{"displayLink":"fda.gov/news-events/press-announcements/fda-approves-new-drug-treatment-chronic-weight-management-first-2014","link":"https://www.fda.gov/news-events/press-announcements/fda-approves-new-drug-treatment-chronic-weight-management-first-2014","title":{"tagName":"span","source":"FDA approves new drug treatment for chronic weight management, first since 2014. (2021)."}},{"displayLink":"ncbi.nlm.nih.gov/pmc/articles/PMC9063254","link":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063254","title":{"tagName":"span","source":"Jensterle, M, et al. (2022). Efficacy of GLP-1 RA approved or weight management in patients with or without diabetes."}},{"displayLink":"ncbi.nlm.nih.gov/pmc/articles/PMC8736331","link":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8736331","title":{"tagName":"span","source":"Mahapatra MK, et al. (2022). Semaglutide, a glucagon like peptide-1 receptor agonist with cardiovascular benefits for management of type 2 diabetes."}},{"displayLink":"fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/medications-containing-semaglutide-marketed-type-2-diabetes-or-weight-loss","link":"https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/medications-containing-semaglutide-marketed-type-2-diabetes-or-weight-loss","title":{"tagName":"span","source":"Medications containing semaglutide marketed for type 2 diabetes or weight loss. (2023)."}},{"displayLink":"nejm.org/doi/10.1056/NEJMoa2032183","link":"https://www.nejm.org/doi/10.1056/NEJMoa2032183","title":{"tagName":"span","source":"Wilding, JPH, et al. (2021). Once-weekly semaglutide in adults with overweight or obesity."}}],"byline":{"authors":[{"id":1410,"name":{"display":"Alysa Hullett","first":"Alysa","last":"Hullett"},"link":"/authors/alysa-hullett","type":{"value":"author","label":"Author"},"nid":"","specialties":[],"guestTitle":"","bio":{"text":"\u003cp\u003eAlysa Hullett is a writer with work in outlets like Healthline, Greatist and the Seattle Times. Her current work revolves around themes of health, science, art and community.\u003c/p\u003e\n"},"avatar":{"title":"","src":""}}],"medicalReviewers":[{"id":6672,"name":{"display":"Philip Ngo, PharmD","first":"Philip","last":"Ngo, PharmD"},"userLogin":"pngo","links":{"website":"","facebook":"","linkedin":"https://www.linkedin.com/in/philipngo1/","twitter":"","instagram":"","tiktok":""},"link":"/reviewers/philip-ngo-pharmd","type":{"value":"medical_reviewer","label":"Medical Advisor"},"nid":"","specialties":[],"guestTitle":"","bio":{"text":"\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eDr. Philip Ngo is a pharmacist with over a decade of experience in community pharmacy. His interests lie in drug information, disease state management, and mental health. He is passionate about educating others on medication use and currently practices in Houston, Texas. \u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eEducation\u003c/strong\u003e\u003c/p\u003e\n\u003cul\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe University of Texas at Austin, BSA\u003c/span\u003e\u003c/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eUniversity of Houston, PharmD\u003c/span\u003e\u003c/li\u003e\n\u003c/ul\u003e\n\u003cp\u003e\u003cstrong\u003eCertifications\u003c/strong\u003e\u003c/p\u003e\n\u003cul\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eLicensed Pharmacist\u003c/span\u003e\u003c/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eHeartsaver First Aid CPR AED (American Heart Association)\u003c/span\u003e\u003c/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eCertified Immunizer\u003c/span\u003e\u003c/li\u003e\n\u003c/ul\u003e\n"},"avatar":{"title":"","width":500,"height":500,"src":"https://post.greatist.com/wp-content/uploads/2022/09/Philip-Ngo-Headshot_500x500-Bio.png"}}],"id":"gr-629626","updateReason":[],"editor":"Lianna Bass","factCheckedBy":"","factCheckers":[],"articleHistory":{"2023-11-02":{"updateReason":[],"authors":"Alysa Hullett","editor":"Lianna Bass","medicallyReviewedBy":"Philip Ngo, PharmD"}},"articleDates":{"factChecked":{"date":null,"display":""},"medicallyReviewed":{"date":1698962400,"display":"November 2, 2023"},"published":{"date":1698962400,"display":"November 2, 2023"},"lastUpdates":{"date":1698962400,"display":"November 2, 2023"},"modified":{"date":1700321096,"display":"November 18, 2023"}},"type":"healthfeature","language":"en"},"isCorp":false,"isReference":false,"isPremiumVideo":false,"isStandaloneVideo":false,"isStandaloneRecipe":false,"schemaObj":{"@context":"https://schema.org","publisher":{"@type":"Organization","name":"Greatist","logo":{"@type":"ImageObject","url":"https://www.healthline.com/hlcmsresource/images/frontend-static/greatist_logo_black.png"}},"@type":"Article","headline":"GLP-1 for Weight Loss: How Does It Work?","description":"GLP-1, a hormone naturally released by the GI tract after eating, can promote weight loss by reducing appetite and slowing down digestion, helping individuals feel full and satisfied. Read on to find out if GLP-1 receptor medications are right for you.","keywords":"glp 1 for weight loss","author":{"@type":"Person","name":"Alysa Hullett"},"lastReviewed":"2023-11-02T22:00:00Z","url":"https://greatist.com/health/glp-1-for-weight-loss","datePublished":"2023-11-02T22:00:00Z","dateModified":"2023-11-02T22:00:00Z","articleSection":"Health","correction":{"@type":"CorrectionComment","text":"","datePublished":"2023-11-02"},"reviewedBy":"Philip Ngo, PharmD","thumbnail":["https://media.post.rvohealth.io/wp-content/uploads/sites/2/2023/03/GRT-ozempic-732x549-thumb-732x549.jpg"]},"hero":{}}},"ampLibs":{},"scrollArticles":[{"title":["Ozempic for Weight Loss: Is It Worth the Risks and Cost?"],"text":["Ozempic is a noninsulin medicine that was designed to improve blood sugar in adults with type 2 diabetes. Recently, there's a growing trend of people…"],"link":"/health/ozempic-for-weight-loss","imageAlt":"Ozempic for Weight Loss: Is It Worth the Risks and Cost?","thumbnail":"https://media.post.rvohealth.io/wp-content/uploads/sites/2/2023/03/GRT-ozempic-732x549-thumb-732x549.jpg","isNutrition":false,"authors":[{"id":440,"name":{"display":"Sarah Garone","first":"Sarah","last":"Garone"},"userLogin":"sgarone","links":{"website":"https://sarahgarone.com","facebook":"","linkedin":"","twitter":"LoveLetter2Food","instagram":"","tiktok":""},"link":"/authors/sarah-garone","type":{"value":"author","label":"Author"},"nid":"","specialties":[],"guestTitle":"","bio":{"text":"\u003cp\u003eSarah Garone is a nutritionist, freelance writer, and food blogger. Find her sharing down-to-earth nutrition info at \u003ca class=\"waffle-rich-text-link\" href=\"http://alovelettertofood.com/\"\u003eA Love Letter to Food\u003c/a\u003e or follow her on \u003ca class=\"waffle-rich-text-link\" href=\"https://twitter.com/LoveLetter2Food?ref_src=twsrc%255Egoogle%257Ctwcamp%255Eserp%257Ctwgr%255Eauthor\"\u003eTwitter\u003c/a\u003e.\u003c/p\u003e\n"},"avatar":{"title":"","width":500,"height":500,"src":"https://post.greatist.com/wp-content/uploads/sites/2/2021/06/Sarah-Head-Shot-Square-Sarah-Garone.jpg"}}],"reviewedByHeader":"Medically reviewed by"},{"title":["Metformin: An Aid for Weight Loss?"],"text":["Curious about metformin for weight loss? 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Find her sharing down-to-earth nutrition info at \u003ca class=\"waffle-rich-text-link\" href=\"http://alovelettertofood.com/\"\u003eA Love Letter to Food\u003c/a\u003e or follow her on \u003ca class=\"waffle-rich-text-link\" href=\"https://twitter.com/LoveLetter2Food?ref_src=twsrc%255Egoogle%257Ctwcamp%255Eserp%257Ctwgr%255Eauthor\"\u003eTwitter\u003c/a\u003e.\u003c/p\u003e\n"},"avatar":{"title":"","width":500,"height":500,"src":"https://post.greatist.com/wp-content/uploads/sites/2/2021/06/Sarah-Head-Shot-Square-Sarah-Garone.jpg"}}],"reviewedByHeader":"Medically reviewed by"},{"title":["Ozempic Butt: Does Ozempic Make Your Butt Saggy?"],"text":["Worried that Ozempic will make your butt sag? Here's what you need to know."],"link":"/health/ozempic-butt","imageAlt":"Ozempic Butt: Does Ozempic Make Your Butt Saggy?","thumbnail":"https://media.post.rvohealth.io/wp-content/uploads/sites/2/2023/11/GRT-female-bathing-suit-butt-peach-fruit-732x549-thumb.jpg","isNutrition":false,"authors":[{"id":556,"name":{"display":"Breanna Mona","first":"Breanna","last":"Mona"},"userLogin":"monabreanna","links":{"website":"","facebook":"","linkedin":"","twitter":"","instagram":"","tiktok":""},"link":"/authors/breanna-mona","type":{"value":"author","label":"Author"},"nid":"","specialties":[],"guestTitle":"","bio":{"text":"\u003cp data-pm-slice=\"1 1 []\"\u003eBreanna Mona is an empathetic writer committed to helping people live their most authentic lives. Her work focuses on general health, wellness, beauty, sexual health, and mental health. Breanna is also a pop culture enthusiast, covering high-profile entertainment stories. 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Find her sharing down-to-earth nutrition info at \u003ca class=\"waffle-rich-text-link\" href=\"http://alovelettertofood.com/\"\u003eA Love Letter to Food\u003c/a\u003e or follow her on \u003ca class=\"waffle-rich-text-link\" href=\"https://twitter.com/LoveLetter2Food?ref_src=twsrc%255Egoogle%257Ctwcamp%255Eserp%257Ctwgr%255Eauthor\"\u003eTwitter\u003c/a\u003e.\u003c/p\u003e\n"},"avatar":{"title":"","width":500,"height":500,"src":"https://post.greatist.com/wp-content/uploads/sites/2/2021/06/Sarah-Head-Shot-Square-Sarah-Garone.jpg"}}],"reviewedByHeader":"Medically reviewed by"},{"title":["How to Ask Your Doctor for Weight Loss Pills: Tips for Success"],"text":["Learn how to ask your doctor for weight loss pills confidently. Get tips on discussing options, BMI criteria, and medication pros and cons."],"link":"/health/how-to-ask-your-doctor-for-weight-loss-pills","imageAlt":"How to Ask Your Doctor for Weight Loss Pills: Tips for Success","thumbnail":"https://media.post.rvohealth.io/wp-content/uploads/sites/2/2023/10/629610-Ozempic-How-to-Ask-Your-Doctor-for-Weight-Loss-Pills-732x549-thumbnail-732x549.jpg","medicallyReviewedBy":{"reviewerName":"E. 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