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container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_14850025 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="14850025"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14850025; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14850025]").text(description); $(".js-view-count-work_14850025").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_14850025").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="14850025"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">21</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="591" href="https://www.academia.edu/Documents/in/Nutrition_and_Dietetics">Nutrition and Dietetics</a>, <script data-card-contents-for-ri="591" type="text/json">{"id":591,"name":"Nutrition and Dietetics","url":"https://www.academia.edu/Documents/in/Nutrition_and_Dietetics?f_ri=8971","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="6791" href="https://www.academia.edu/Documents/in/Aging">Aging</a>, <script data-card-contents-for-ri="6791" type="text/json">{"id":6791,"name":"Aging","url":"https://www.academia.edu/Documents/in/Aging?f_ri=8971","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="8971" href="https://www.academia.edu/Documents/in/Mild_Cognitive_Impairment">Mild Cognitive Impairment</a>, <script data-card-contents-for-ri="8971" type="text/json">{"id":8971,"name":"Mild Cognitive Impairment","url":"https://www.academia.edu/Documents/in/Mild_Cognitive_Impairment?f_ri=8971","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9478" href="https://www.academia.edu/Documents/in/Diet">Diet</a><script data-card-contents-for-ri="9478" type="text/json">{"id":9478,"name":"Diet","url":"https://www.academia.edu/Documents/in/Diet?f_ri=8971","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=14850025]'), work: {"id":14850025,"title":"Plasma free choline, betaine and cognitive performance: the Hordaland Health 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factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=8971"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=8971"},{"id":568482,"name":"Biological markers","url":"https://www.academia.edu/Documents/in/Biological_markers?f_ri=8971"},{"id":573653,"name":"Food Sciences","url":"https://www.academia.edu/Documents/in/Food_Sciences?f_ri=8971"},{"id":584602,"name":"Geriatric Assessment","url":"https://www.academia.edu/Documents/in/Geriatric_Assessment?f_ri=8971"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=8971"},{"id":990296,"name":"Choline","url":"https://www.academia.edu/Documents/in/Choline?f_ri=8971"},{"id":1034181,"name":"Cross Sectional Studies","url":"https://www.academia.edu/Documents/in/Cross_Sectional_Studies?f_ri=8971"},{"id":1716295,"name":"vitamin B deficiency","url":"https://www.academia.edu/Documents/in/vitamin_B_deficiency?f_ri=8971"},{"id":1819400,"name":"Cohort Studies","url":"https://www.academia.edu/Documents/in/Cohort_Studies?f_ri=8971"},{"id":2190576,"name":"Betaine","url":"https://www.academia.edu/Documents/in/Betaine?f_ri=8971"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_19191278" data-work_id="19191278" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/19191278/Stability_of_Different_Subtypes_of_Mild_Cognitive_Impairment_among_the_Elderly_over_a_2_to_3_Year_Follow_Up_Period">Stability of Different Subtypes of Mild Cognitive Impairment among the Elderly over a 2- to 3-Year Follow-Up Period</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a 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class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="39406159" href="https://miami.academia.edu/DavidLoewenstein">David Loewenstein</a><script data-card-contents-for-user="39406159" type="text/json">{"id":39406159,"first_name":"David","last_name":"Loewenstein","domain_name":"miami","page_name":"DavidLoewenstein","display_name":"David Loewenstein","profile_url":"https://miami.academia.edu/DavidLoewenstein?f_ri=8971","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_19191278 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="19191278"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new 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data-card-contents-for-ri="237" type="text/json">{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=8971","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="4531" href="https://www.academia.edu/Documents/in/Clinical_Trial">Clinical Trial</a>, <script data-card-contents-for-ri="4531" type="text/json">{"id":4531,"name":"Clinical Trial","url":"https://www.academia.edu/Documents/in/Clinical_Trial?f_ri=8971","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="8971" href="https://www.academia.edu/Documents/in/Mild_Cognitive_Impairment">Mild Cognitive Impairment</a>, <script data-card-contents-for-ri="8971" type="text/json">{"id":8971,"name":"Mild Cognitive Impairment","url":"https://www.academia.edu/Documents/in/Mild_Cognitive_Impairment?f_ri=8971","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="18174" href="https://www.academia.edu/Documents/in/Language">Language</a><script data-card-contents-for-ri="18174" type="text/json">{"id":18174,"name":"Language","url":"https://www.academia.edu/Documents/in/Language?f_ri=8971","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=19191278]'), work: {"id":19191278,"title":"Stability of Different Subtypes of Mild Cognitive Impairment among the Elderly over a 2- to 3-Year Follow-Up Period","created_at":"2015-11-29T12:20:16.706-08:00","url":"https://www.academia.edu/19191278/Stability_of_Different_Subtypes_of_Mild_Cognitive_Impairment_among_the_Elderly_over_a_2_to_3_Year_Follow_Up_Period?f_ri=8971","dom_id":"work_19191278","summary":null,"downloadable_attachments":[{"id":40481825,"asset_id":19191278,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":39406159,"first_name":"David","last_name":"Loewenstein","domain_name":"miami","page_name":"DavidLoewenstein","display_name":"David Loewenstein","profile_url":"https://miami.academia.edu/DavidLoewenstein?f_ri=8971","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=8971","nofollow":false},{"id":4531,"name":"Clinical Trial","url":"https://www.academia.edu/Documents/in/Clinical_Trial?f_ri=8971","nofollow":false},{"id":8971,"name":"Mild Cognitive 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Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=8971"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=8971"},{"id":295155,"name":"Middle Aged","url":"https://www.academia.edu/Documents/in/Middle_Aged?f_ri=8971"},{"id":330953,"name":"Longitudinal Studies","url":"https://www.academia.edu/Documents/in/Longitudinal_Studies?f_ri=8971"},{"id":341121,"name":"Cognitive impairment","url":"https://www.academia.edu/Documents/in/Cognitive_impairment?f_ri=8971"},{"id":413194,"name":"Analysis of Variance","url":"https://www.academia.edu/Documents/in/Analysis_of_Variance?f_ri=8971"},{"id":584615,"name":"Disease Progression","url":"https://www.academia.edu/Documents/in/Disease_Progression?f_ri=8971"},{"id":806178,"name":"Older Adult","url":"https://www.academia.edu/Documents/in/Older_Adult?f_ri=8971"},{"id":1036777,"name":"Epidemiologic Studies","url":"https://www.academia.edu/Documents/in/Epidemiologic_Studies?f_ri=8971"},{"id":1126675,"name":"Memory Testing","url":"https://www.academia.edu/Documents/in/Memory_Testing?f_ri=8971"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=8971"},{"id":1627527,"name":"Cognition disorders","url":"https://www.academia.edu/Documents/in/Cognition_disorders?f_ri=8971"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_70514777" data-work_id="70514777" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/70514777/Effect_of_long_term_individual_cognitive_stimulation_intervention_for_people_with_mild_neurocognitive_disorder">Effect of long-term individual cognitive stimulation intervention for people with mild neurocognitive disorder</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">INTRODUCTION Cognitive stimulation may be beneficial in slowing the progression of mild neurocognitive disorder (NCD), but the results of existing research are inconsistent. Furthermore, there are no long-term interventions nor individual... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_70514777" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">INTRODUCTION Cognitive stimulation may be beneficial in slowing the progression of mild neurocognitive disorder (NCD), but the results of existing research are inconsistent. Furthermore, there are no long-term interventions nor individual (one-on-one) interventions applied by professionals. Objetive. The aim of this study was to assess the efficacy of a long-term individual cognitive stimulation intervention on people with mild NCD. PATIENTS AND METHODS A pre-post test design with a non-equivalent control group was conducted. A total of 82 participants with mild NCD were assigned to a cognitive stimulation intervention group or to a control group. The intervention consisted of 88 individual format sessions of approximately 45 minutes, twice per week. Independent evaluators assessed cognition, depressive symptomatology and autonomy level in activities of daily living at pre-intervention, intra-intervention (6 months) and post-intervention (12 months). RESULTS At intra- and post-inter...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/70514777" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c46861c49cd3ef17db304297564000a2" rel="nofollow" data-download="{"attachment_id":80331697,"asset_id":70514777,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/80331697/download_file?st=MTczMjQ0MDMyMyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="113724532" href="https://independent.academia.edu/SusanaJustoHenriques">Susana Justo-Henriques</a><script data-card-contents-for-user="113724532" type="text/json">{"id":113724532,"first_name":"Susana","last_name":"Justo-Henriques","domain_name":"independent","page_name":"SusanaJustoHenriques","display_name":"Susana Justo-Henriques","profile_url":"https://independent.academia.edu/SusanaJustoHenriques?f_ri=8971","photo":"https://0.academia-photos.com/113724532/55993379/44184283/s65_susana.justo_henriques.jpg"}</script></span></span></li><li class="js-paper-rank-work_70514777 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="70514777"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 70514777, container: ".js-paper-rank-work_70514777", }); });</script></li><li class="js-percentile-work_70514777 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 70514777; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_70514777"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_70514777 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="70514777"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 70514777; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=70514777]").text(description); $(".js-view-count-work_70514777").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_70514777").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="70514777"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">8</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="3217" href="https://www.academia.edu/Documents/in/Depression">Depression</a>, <script data-card-contents-for-ri="3217" type="text/json">{"id":3217,"name":"Depression","url":"https://www.academia.edu/Documents/in/Depression?f_ri=8971","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="3662" href="https://www.academia.edu/Documents/in/Dementia">Dementia</a>, <script data-card-contents-for-ri="3662" type="text/json">{"id":3662,"name":"Dementia","url":"https://www.academia.edu/Documents/in/Dementia?f_ri=8971","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="8971" href="https://www.academia.edu/Documents/in/Mild_Cognitive_Impairment">Mild Cognitive Impairment</a>, <script data-card-contents-for-ri="8971" type="text/json">{"id":8971,"name":"Mild Cognitive Impairment","url":"https://www.academia.edu/Documents/in/Mild_Cognitive_Impairment?f_ri=8971","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="50563" href="https://www.academia.edu/Documents/in/Older_Adults">Older Adults</a><script data-card-contents-for-ri="50563" type="text/json">{"id":50563,"name":"Older Adults","url":"https://www.academia.edu/Documents/in/Older_Adults?f_ri=8971","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=70514777]'), work: {"id":70514777,"title":"Effect of long-term individual cognitive stimulation intervention for people with mild neurocognitive disorder","created_at":"2022-02-05T02:13:09.177-08:00","url":"https://www.academia.edu/70514777/Effect_of_long_term_individual_cognitive_stimulation_intervention_for_people_with_mild_neurocognitive_disorder?f_ri=8971","dom_id":"work_70514777","summary":"INTRODUCTION Cognitive stimulation may be beneficial in slowing the progression of mild neurocognitive disorder (NCD), but the results of existing research are inconsistent. Furthermore, there are no long-term interventions nor individual (one-on-one) interventions applied by professionals. Objetive. The aim of this study was to assess the efficacy of a long-term individual cognitive stimulation intervention on people with mild NCD. PATIENTS AND METHODS A pre-post test design with a non-equivalent control group was conducted. A total of 82 participants with mild NCD were assigned to a cognitive stimulation intervention group or to a control group. The intervention consisted of 88 individual format sessions of approximately 45 minutes, twice per week. Independent evaluators assessed cognition, depressive symptomatology and autonomy level in activities of daily living at pre-intervention, intra-intervention (6 months) and post-intervention (12 months). RESULTS At intra- and post-inter...","downloadable_attachments":[{"id":80331697,"asset_id":70514777,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":113724532,"first_name":"Susana","last_name":"Justo-Henriques","domain_name":"independent","page_name":"SusanaJustoHenriques","display_name":"Susana Justo-Henriques","profile_url":"https://independent.academia.edu/SusanaJustoHenriques?f_ri=8971","photo":"https://0.academia-photos.com/113724532/55993379/44184283/s65_susana.justo_henriques.jpg"}],"research_interests":[{"id":3217,"name":"Depression","url":"https://www.academia.edu/Documents/in/Depression?f_ri=8971","nofollow":false},{"id":3662,"name":"Dementia","url":"https://www.academia.edu/Documents/in/Dementia?f_ri=8971","nofollow":false},{"id":8971,"name":"Mild Cognitive Impairment","url":"https://www.academia.edu/Documents/in/Mild_Cognitive_Impairment?f_ri=8971","nofollow":false},{"id":50563,"name":"Older Adults","url":"https://www.academia.edu/Documents/in/Older_Adults?f_ri=8971","nofollow":false},{"id":476517,"name":"Psychosocial Interventions","url":"https://www.academia.edu/Documents/in/Psychosocial_Interventions?f_ri=8971"},{"id":1292302,"name":"Cognitive Stimulation","url":"https://www.academia.edu/Documents/in/Cognitive_Stimulation?f_ri=8971"},{"id":2467526,"name":"Neurocognitive Disorders/diagnosis","url":"https://www.academia.edu/Documents/in/Neurocognitive_Disorders_diagnosis?f_ri=8971"},{"id":4084630,"name":"Alzheimer´s disease","url":"https://www.academia.edu/Documents/in/Alzheimer_s_disease-1?f_ri=8971"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_36447191" data-work_id="36447191" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/36447191/Indicadores_neuropsicol%C3%B3gicos_de_evoluci%C3%B3n_a_demencia_tipo_Alzheimer_en_pacientes_diagnosticados_con_deterioro_cognitivo_leve">Indicadores neuropsicológicos de evolución a demencia tipo Alzheimer en pacientes diagnosticados con deterioro cognitivo leve</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The objective of this investigation done in the Neuropsychological Section of the Hospital Universitario de Caracas was to identify the main indicators in a battery of neuropsychological tests that permit to predict the evolution to... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_36447191" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The objective of this investigation done in the Neuropsychological Section of the Hospital Universitario de Caracas was to identify the main indicators in a battery of neuropsychological tests that permit to predict the evolution to Dementia of the Alzheimer´s Type (DTA) in patients previously diagnosed with Mild Cognitive Impairment (MCI). Through a non probabilistic sampling we got a sample of 30 patients from both gender, 46 to 81 years old, whose evolution was evaluated generating two diagnostic groups: DTA and MCI. The results were analized with U-Mann Whitney’s coefficient; we found that the Rey’s Audioverbal Learning Test intent VII, index V-VII, I-VI and errors in R were the ones who could discriminate both groups.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/36447191" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="74a79a057256cebba93abf2e113dffba" rel="nofollow" data-download="{"attachment_id":56361839,"asset_id":36447191,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/56361839/download_file?st=MTczMjQ0MDMyMyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="80789627" href="https://ucv.academia.edu/IlvaCampagna">Ilva Campagna</a><script data-card-contents-for-user="80789627" type="text/json">{"id":80789627,"first_name":"Ilva","last_name":"Campagna","domain_name":"ucv","page_name":"IlvaCampagna","display_name":"Ilva Campagna","profile_url":"https://ucv.academia.edu/IlvaCampagna?f_ri=8971","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_36447191 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="36447191"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 36447191, container: ".js-paper-rank-work_36447191", }); });</script></li><li class="js-percentile-work_36447191 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 36447191; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_36447191"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_36447191 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="36447191"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 36447191; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=36447191]").text(description); $(".js-view-count-work_36447191").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_36447191").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="36447191"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">6</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="2599" href="https://www.academia.edu/Documents/in/Psychometrics">Psychometrics</a>, <script data-card-contents-for-ri="2599" type="text/json">{"id":2599,"name":"Psychometrics","url":"https://www.academia.edu/Documents/in/Psychometrics?f_ri=8971","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="3776" href="https://www.academia.edu/Documents/in/Alzheimers_Disease">Alzheimer's Disease</a>, <script data-card-contents-for-ri="3776" type="text/json">{"id":3776,"name":"Alzheimer's Disease","url":"https://www.academia.edu/Documents/in/Alzheimers_Disease?f_ri=8971","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="8971" href="https://www.academia.edu/Documents/in/Mild_Cognitive_Impairment">Mild Cognitive Impairment</a>, <script data-card-contents-for-ri="8971" type="text/json">{"id":8971,"name":"Mild Cognitive Impairment","url":"https://www.academia.edu/Documents/in/Mild_Cognitive_Impairment?f_ri=8971","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="10591" href="https://www.academia.edu/Documents/in/Clinical_And_Neuropsychological_Assessment">Clinical And Neuropsychological Assessment</a><script data-card-contents-for-ri="10591" type="text/json">{"id":10591,"name":"Clinical And Neuropsychological Assessment","url":"https://www.academia.edu/Documents/in/Clinical_And_Neuropsychological_Assessment?f_ri=8971","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=36447191]'), work: {"id":36447191,"title":"Indicadores neuropsicológicos de evolución a demencia tipo Alzheimer en pacientes diagnosticados con deterioro cognitivo leve","created_at":"2018-04-19T16:30:27.472-07:00","url":"https://www.academia.edu/36447191/Indicadores_neuropsicol%C3%B3gicos_de_evoluci%C3%B3n_a_demencia_tipo_Alzheimer_en_pacientes_diagnosticados_con_deterioro_cognitivo_leve?f_ri=8971","dom_id":"work_36447191","summary":"The objective of this investigation done in the Neuropsychological Section of the Hospital Universitario de Caracas was to identify the main indicators in a battery of neuropsychological tests that permit to predict the evolution to Dementia of the Alzheimer´s Type (DTA) in patients previously diagnosed with Mild Cognitive Impairment (MCI). Through a non probabilistic sampling we got a sample of 30 patients from both gender, 46 to 81 years old, whose evolution was evaluated generating two diagnostic groups: DTA and MCI. The results were analized with U-Mann Whitney’s coefficient; we found that the Rey’s Audioverbal Learning Test intent VII, index V-VII, I-VI and errors in R were the ones who could discriminate both groups.","downloadable_attachments":[{"id":56361839,"asset_id":36447191,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":80789627,"first_name":"Ilva","last_name":"Campagna","domain_name":"ucv","page_name":"IlvaCampagna","display_name":"Ilva Campagna","profile_url":"https://ucv.academia.edu/IlvaCampagna?f_ri=8971","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":2599,"name":"Psychometrics","url":"https://www.academia.edu/Documents/in/Psychometrics?f_ri=8971","nofollow":false},{"id":3776,"name":"Alzheimer's Disease","url":"https://www.academia.edu/Documents/in/Alzheimers_Disease?f_ri=8971","nofollow":false},{"id":8971,"name":"Mild Cognitive Impairment","url":"https://www.academia.edu/Documents/in/Mild_Cognitive_Impairment?f_ri=8971","nofollow":false},{"id":10591,"name":"Clinical And Neuropsychological Assessment","url":"https://www.academia.edu/Documents/in/Clinical_And_Neuropsychological_Assessment?f_ri=8971","nofollow":false},{"id":361229,"name":"Alzheimer Dementia","url":"https://www.academia.edu/Documents/in/Alzheimer_Dementia?f_ri=8971"},{"id":2938561,"name":"Rey Auditory Verbal Learning Test ","url":"https://www.academia.edu/Documents/in/Rey_Auditory_Verbal_Learning_Test?f_ri=8971"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_11738620" data-work_id="11738620" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/11738620/The_relationship_of_white_matter_hyperintensities_with_perfusion_and_cognition_in_middle_aged_adults_at_risk_for_Alzheimers_disease">The relationship of white matter hyperintensities with perfusion and cognition in middle-aged adults at risk for Alzheimer's disease</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/11738620" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="cb54dc4b5d2e07f249dde7ff5241939e" rel="nofollow" data-download="{"attachment_id":46551894,"asset_id":11738620,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/46551894/download_file?st=MTczMjQ0MDMyMyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="28808195" href="https://independent.academia.edu/VikasSingh138">Vikas Singh</a><script data-card-contents-for-user="28808195" type="text/json">{"id":28808195,"first_name":"Vikas","last_name":"Singh","domain_name":"independent","page_name":"VikasSingh138","display_name":"Vikas Singh","profile_url":"https://independent.academia.edu/VikasSingh138?f_ri=8971","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_11738620 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="11738620"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 11738620, container: ".js-paper-rank-work_11738620", }); 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We recently completed a cross-sectional study to test the hypothesis that a combination of a brief cognitive screening instrument (Mini-Cog) with... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_67032937" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Mild cognitive impairment (MCI) often presages development of Alzheimer&#39;s disease (AD). We recently completed a cross-sectional study to test the hypothesis that a combination of a brief cognitive screening instrument (Mini-Cog) with a functional scale (Functional Activities Questionnaire; FAQ) would accurately identify individuals with MCI and undiagnosed dementia. The Mini-Cog consists of a clock drawing task and 3-item recall, and takes less than 5 minutes to administer. The FAQ is a 30-item questionnaire completed by an informant. In addition to the Mini-Cog and FAQ, a traditional cognitive test battery was administered, and two neurologists and a neuropsychologist determined a consensus diagnosis of Normal, MCI, or Dementia. A classification tree algorithm was used to pick optimal cutpoints, and, using these cutpoints, the combined Mini-Cog and FAQ (MC-FAQ) predicted the consensus diagnosis with an accuracy of 83% and a weighted kappa of 0.81. When the population was divide...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/67032937" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="fe320e59354a252ab40a8330c60d2a76" rel="nofollow" data-download="{"attachment_id":78005230,"asset_id":67032937,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/78005230/download_file?st=MTczMjQ0MDMyMyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="165123886" href="https://independent.academia.edu/kylesteenland">kyle steenland</a><script data-card-contents-for-user="165123886" type="text/json">{"id":165123886,"first_name":"kyle","last_name":"steenland","domain_name":"independent","page_name":"kylesteenland","display_name":"kyle steenland","profile_url":"https://independent.academia.edu/kylesteenland?f_ri=8971","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_67032937 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="67032937"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 67032937, container: ".js-paper-rank-work_67032937", }); 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$(".js-view-count[data-work-id=67032937]").text(description); $(".js-view-count-work_67032937").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_67032937").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="67032937"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">20</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="237" href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a>, <script data-card-contents-for-ri="237" type="text/json">{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=8971","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="3662" href="https://www.academia.edu/Documents/in/Dementia">Dementia</a>, <script data-card-contents-for-ri="3662" type="text/json">{"id":3662,"name":"Dementia","url":"https://www.academia.edu/Documents/in/Dementia?f_ri=8971","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="7736" href="https://www.academia.edu/Documents/in/Attention">Attention</a>, <script data-card-contents-for-ri="7736" type="text/json">{"id":7736,"name":"Attention","url":"https://www.academia.edu/Documents/in/Attention?f_ri=8971","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="8971" href="https://www.academia.edu/Documents/in/Mild_Cognitive_Impairment">Mild Cognitive Impairment</a><script data-card-contents-for-ri="8971" type="text/json">{"id":8971,"name":"Mild Cognitive Impairment","url":"https://www.academia.edu/Documents/in/Mild_Cognitive_Impairment?f_ri=8971","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=67032937]'), work: {"id":67032937,"title":"Development of a rapid screening instrument for mild cognitive impairment and undiagnosed dementia","created_at":"2022-01-04T01:42:54.217-08:00","url":"https://www.academia.edu/67032937/Development_of_a_rapid_screening_instrument_for_mild_cognitive_impairment_and_undiagnosed_dementia?f_ri=8971","dom_id":"work_67032937","summary":"Mild cognitive impairment (MCI) often presages development of Alzheimer\u0026#39;s disease (AD). We recently completed a cross-sectional study to test the hypothesis that a combination of a brief cognitive screening instrument (Mini-Cog) with a functional scale (Functional Activities Questionnaire; FAQ) would accurately identify individuals with MCI and undiagnosed dementia. The Mini-Cog consists of a clock drawing task and 3-item recall, and takes less than 5 minutes to administer. The FAQ is a 30-item questionnaire completed by an informant. In addition to the Mini-Cog and FAQ, a traditional cognitive test battery was administered, and two neurologists and a neuropsychologist determined a consensus diagnosis of Normal, MCI, or Dementia. A classification tree algorithm was used to pick optimal cutpoints, and, using these cutpoints, the combined Mini-Cog and FAQ (MC-FAQ) predicted the consensus diagnosis with an accuracy of 83% and a weighted kappa of 0.81. When the population was divide...","downloadable_attachments":[{"id":78005230,"asset_id":67032937,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":165123886,"first_name":"kyle","last_name":"steenland","domain_name":"independent","page_name":"kylesteenland","display_name":"kyle steenland","profile_url":"https://independent.academia.edu/kylesteenland?f_ri=8971","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=8971","nofollow":false},{"id":3662,"name":"Dementia","url":"https://www.academia.edu/Documents/in/Dementia?f_ri=8971","nofollow":false},{"id":7736,"name":"Attention","url":"https://www.academia.edu/Documents/in/Attention?f_ri=8971","nofollow":false},{"id":8971,"name":"Mild Cognitive Impairment","url":"https://www.academia.edu/Documents/in/Mild_Cognitive_Impairment?f_ri=8971","nofollow":false},{"id":18174,"name":"Language","url":"https://www.academia.edu/Documents/in/Language?f_ri=8971"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=8971"},{"id":44529,"name":"Activities of Daily Living","url":"https://www.academia.edu/Documents/in/Activities_of_Daily_Living?f_ri=8971"},{"id":46858,"name":"Memory","url":"https://www.academia.edu/Documents/in/Memory?f_ri=8971"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=8971"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female?f_ri=8971"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male?f_ri=8971"},{"id":113865,"name":"Decision Tree Classification","url":"https://www.academia.edu/Documents/in/Decision_Tree_Classification?f_ri=8971"},{"id":244814,"name":"Clinical 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u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/7897860/Detection_of_visuoperceptual_deficits_in_preclinical_and_mild_Alzheimers_disease">Detection of visuoperceptual deficits in preclinical and mild Alzheimer's disease</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Exhaustive neuropsychological assessment of mild cognitive impairment (MCI) subjects frequently identifies cognitive deficits other than memory. However, visuoperception has rarely been investigated in MCI. The 15-Objects Test (15-OT), a... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_7897860" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Exhaustive neuropsychological assessment of mild cognitive impairment (MCI) subjects frequently identifies cognitive deficits other than memory. However, visuoperception has rarely been investigated in MCI. The 15-Objects Test (15-OT), a visual discrimination task based on the Poppelreuter Test, consists of 15 overlapping objects. Poppelreuter-type tests are frequently used to detect visual agnosia. However, more complex tests, such as the 15-OT, are required to detect visuoperceptual signs in those patients who perform correctly on simple tests. The aim of the present study was to investigate visuoperceptual deficits in MCI patients and to assess the usefulness of the 15-OT to discriminate Alzheimer's disease (AD) and MCI patients from controls. The 15-OT, and a neuropsychological battery included in the diagnostic assessment, was administered to 44 healthy controls, 44 MCI patients, and 44 mild AD patients. Performance on the 15-OT was significantly different between groups. MCI scored between AD and controls. When MCI and AD patients had relatively normal performance on simple tests (Poppelreuter), increased significant abnormalities were found by a more difficult visuoperceptual test (15-OT). Regression analyses showed that the 15-OT was a significant predictor of group membership, but the Poppelreuter Test did not significantly contribute to the models. Visuoperceptual processing is impaired early in the clinical course of AD. The 15-OT allows detection of visuoperceptual deficits in the preclinical and mild AD stages, when classical tests are still unable to detect subtle deficits. So, its inclusion in neuropsychological batteries that are nowadays used in the clinical practice would allow increasing their diagnostic potential.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/7897860" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="5e8fcb91f3b2ed14350e45754ce57ed9" rel="nofollow" data-download="{"attachment_id":48297693,"asset_id":7897860,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/48297693/download_file?st=MTczMjQ0MDMyNCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="14783907" href="https://independent.academia.edu/AnaEspinosa7">Ana Espinosa</a><script data-card-contents-for-user="14783907" type="text/json">{"id":14783907,"first_name":"Ana","last_name":"Espinosa","domain_name":"independent","page_name":"AnaEspinosa7","display_name":"Ana Espinosa","profile_url":"https://independent.academia.edu/AnaEspinosa7?f_ri=8971","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_7897860 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="7897860"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 7897860, container: ".js-paper-rank-work_7897860", }); 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However, visuoperception has rarely been investigated in MCI. The 15-Objects Test (15-OT), a visual discrimination task based on the Poppelreuter Test, consists of 15 overlapping objects. Poppelreuter-type tests are frequently used to detect visual agnosia. However, more complex tests, such as the 15-OT, are required to detect visuoperceptual signs in those patients who perform correctly on simple tests. The aim of the present study was to investigate visuoperceptual deficits in MCI patients and to assess the usefulness of the 15-OT to discriminate Alzheimer's disease (AD) and MCI patients from controls. The 15-OT, and a neuropsychological battery included in the diagnostic assessment, was administered to 44 healthy controls, 44 MCI patients, and 44 mild AD patients. Performance on the 15-OT was significantly different between groups. MCI scored between AD and controls. When MCI and AD patients had relatively normal performance on simple tests (Poppelreuter), increased significant abnormalities were found by a more difficult visuoperceptual test (15-OT). Regression analyses showed that the 15-OT was a significant predictor of group membership, but the Poppelreuter Test did not significantly contribute to the models. Visuoperceptual processing is impaired early in the clinical course of AD. The 15-OT allows detection of visuoperceptual deficits in the preclinical and mild AD stages, when classical tests are still unable to detect subtle deficits. 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href="https://www.academia.edu/25546560/Parkinsons_disease_mild_cognitive_impairment_application_and_validation_of_the_criteria">Parkinson's disease mild cognitive impairment: application and validation of the criteria</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Dementia in Parkinson&#39;s disease (PD) is a serious health issue and a major concern for many patients. In most cases mild cognitive impairment (MCI) is considered a transitional stage between normal cognitive functioning and dementia... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_25546560" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Dementia in Parkinson&#39;s disease (PD) is a serious health issue and a major concern for many patients. In most cases mild cognitive impairment (MCI) is considered a transitional stage between normal cognitive functioning and dementia which is of potential importance in the early identification of patients at risk for dementia. Recently, the Movement Disorder Society (MDS) proposed diagnostic criteria for MCI in PD (PD-MCI). These criteria comprise two operationalizations: Level I (based on an abbreviated assessment) and Level II (based on comprehensive neuropsychological evaluation permitting MCI subtyping). These criteria need to be validated. This paper describes a project aiming to validate the MDS PD-MCI criteria by pooling and analyzing cross-sectional and longitudinal neuropsychological databases comprising ≥5,500 PD patients and ≥1,700 controls. After applying the MDS PD-MCI Level I and Level II criteria, rates of conversion to PD-dementia and predictive variables for conv...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/25546560" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="1255dbf7c51662045a3fb1cd146c7da7" rel="nofollow" data-download="{"attachment_id":45878723,"asset_id":25546560,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/45878723/download_file?st=MTczMjQ0MDMyNCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="34912913" href="https://metamedicavumc.academia.edu/MartinKlein">Martin Klein</a><script data-card-contents-for-user="34912913" type="text/json">{"id":34912913,"first_name":"Martin","last_name":"Klein","domain_name":"metamedicavumc","page_name":"MartinKlein","display_name":"Martin Klein","profile_url":"https://metamedicavumc.academia.edu/MartinKlein?f_ri=8971","photo":"https://0.academia-photos.com/34912913/10171501/11350382/s65_martin.klein.jpg"}</script></span></span></li><li class="js-paper-rank-work_25546560 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="25546560"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 25546560, container: ".js-paper-rank-work_25546560", }); 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In most cases mild cognitive impairment (MCI) is considered a transitional stage between normal cognitive functioning and dementia which is of potential importance in the early identification of patients at risk for dementia. Recently, the Movement Disorder Society (MDS) proposed diagnostic criteria for MCI in PD (PD-MCI). These criteria comprise two operationalizations: Level I (based on an abbreviated assessment) and Level II (based on comprehensive neuropsychological evaluation permitting MCI subtyping). These criteria need to be validated. This paper describes a project aiming to validate the MDS PD-MCI criteria by pooling and analyzing cross-sectional and longitudinal neuropsychological databases comprising ≥5,500 PD patients and ≥1,700 controls. 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effect in patients with Alzheimer's disease and mild cognitive impairment</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/14013581" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="1aec25609e54c96f92d88b76f6a25e6a" rel="nofollow" data-download="{"attachment_id":44706312,"asset_id":14013581,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" 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tetniczo-zylna rdzenia kregowego (SDAVF, spinal dural arteriovenous fi stula) jest rzadkim schorzeniem, rozpoznawanym glownie u mezczyzn w 5.–6. dekadzie zycia. Klinicznie najcześciej objawia sie stopniowo narastającym... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_64357267" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Przetoka oponowa tetniczo-zylna rdzenia kregowego (SDAVF, spinal dural arteriovenous fi stula) jest rzadkim schorzeniem, rozpoznawanym glownie u mezczyzn w 5.–6. dekadzie zycia. Klinicznie najcześciej objawia sie stopniowo narastającym oslabieniem sily mieśniowej konczyn z towarzyszącym upośledzeniem sprawności chodu, parestezjami oraz zaburzeniami oddawania moczu. Podlozem przetoki oponowej jest postepująca mielopatia, wtorna do zastoju krązenia krwi w obrebie rdzenia kregowego. Jedynym sposobem zatrzymania postepu objawow schorzenia jest zabieg operacyjny lub wewnątrznaczyniowe zamkniecie przetoki oponowej. Autorzy przedstawili opis przypadku 53-letniej kobiety z niewielkim oslabieniem lewej konczyny dolnej i towarzyszącymi parestezjami o naglym początku. W badaniach neuroobrazowych u tej chorej stwierdzono obecnośc SDAVF na wysokości trzonow kregowych Th5–Th6. Pacjentke zakwalifi kowano do zabiegu wewnątrznaczyniowego zamkniecia przetoki, po ktorym uzyskano ustąpienie objawow kli...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/64357267" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="2e26551ae61462d6b2587ea3f2ef5349" rel="nofollow" data-download="{"attachment_id":76430091,"asset_id":64357267,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/76430091/download_file?st=MTczMjQ0MDMyNCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="41260540" href="https://independent.academia.edu/MieszkoZagrajek">Mieszko Zagrajek</a><script data-card-contents-for-user="41260540" type="text/json">{"id":41260540,"first_name":"Mieszko","last_name":"Zagrajek","domain_name":"independent","page_name":"MieszkoZagrajek","display_name":"Mieszko Zagrajek","profile_url":"https://independent.academia.edu/MieszkoZagrajek?f_ri=8971","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_64357267 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="64357267"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 64357267, container: ".js-paper-rank-work_64357267", }); });</script></li><li class="js-percentile-work_64357267 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 64357267; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_64357267"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_64357267 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="64357267"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 64357267; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=64357267]").text(description); $(".js-view-count-work_64357267").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_64357267").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="64357267"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i></div><span class="InlineList-item-text u-textTruncate u-pl6x"><a class="InlineList-item-text" data-has-card-for-ri="8971" href="https://www.academia.edu/Documents/in/Mild_Cognitive_Impairment">Mild Cognitive Impairment</a><script data-card-contents-for-ri="8971" type="text/json">{"id":8971,"name":"Mild Cognitive Impairment","url":"https://www.academia.edu/Documents/in/Mild_Cognitive_Impairment?f_ri=8971","nofollow":false}</script></span></li><script>(function(){ if (false) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=64357267]'), work: {"id":64357267,"title":"Przetoka oponowa tętniczo-żylna rdzenia kręgowego","created_at":"2021-12-15T12:13:08.776-08:00","url":"https://www.academia.edu/64357267/Przetoka_oponowa_t%C4%99tniczo_%C5%BCylna_rdzenia_kr%C4%99gowego?f_ri=8971","dom_id":"work_64357267","summary":"Przetoka oponowa tetniczo-zylna rdzenia kregowego (SDAVF, spinal dural arteriovenous fi stula) jest rzadkim schorzeniem, rozpoznawanym glownie u mezczyzn w 5.–6. dekadzie zycia. Klinicznie najcześciej objawia sie stopniowo narastającym oslabieniem sily mieśniowej konczyn z towarzyszącym upośledzeniem sprawności chodu, parestezjami oraz zaburzeniami oddawania moczu. Podlozem przetoki oponowej jest postepująca mielopatia, wtorna do zastoju krązenia krwi w obrebie rdzenia kregowego. Jedynym sposobem zatrzymania postepu objawow schorzenia jest zabieg operacyjny lub wewnątrznaczyniowe zamkniecie przetoki oponowej. Autorzy przedstawili opis przypadku 53-letniej kobiety z niewielkim oslabieniem lewej konczyny dolnej i towarzyszącymi parestezjami o naglym początku. W badaniach neuroobrazowych u tej chorej stwierdzono obecnośc SDAVF na wysokości trzonow kregowych Th5–Th6. 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Moraes</a><script data-card-contents-for-user="25157637" type="text/json">{"id":25157637,"first_name":"Edgar","last_name":"Nunes de Moraes","domain_name":"independent","page_name":"EdgarNunesdeMoraes","display_name":"Edgar Nunes de Moraes","profile_url":"https://independent.academia.edu/EdgarNunesdeMoraes?f_ri=8971","photo":"https://0.academia-photos.com/25157637/18859002/39984244/s65_edgar.nunes_de_moraes.jpeg"}</script></span></span></li><li class="js-paper-rank-work_45413088 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="45413088"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 45413088, container: ".js-paper-rank-work_45413088", }); });</script></li><li class="js-percentile-work_45413088 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x 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$(".js-view-count-work_45413088").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_45413088").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="45413088"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">20</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="2599" href="https://www.academia.edu/Documents/in/Psychometrics">Psychometrics</a>, <script data-card-contents-for-ri="2599" type="text/json">{"id":2599,"name":"Psychometrics","url":"https://www.academia.edu/Documents/in/Psychometrics?f_ri=8971","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="3243" href="https://www.academia.edu/Documents/in/Nonparametric_Statistics">Nonparametric Statistics</a>, <script data-card-contents-for-ri="3243" type="text/json">{"id":3243,"name":"Nonparametric Statistics","url":"https://www.academia.edu/Documents/in/Nonparametric_Statistics?f_ri=8971","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="8971" href="https://www.academia.edu/Documents/in/Mild_Cognitive_Impairment">Mild Cognitive Impairment</a>, <script data-card-contents-for-ri="8971" type="text/json">{"id":8971,"name":"Mild Cognitive Impairment","url":"https://www.academia.edu/Documents/in/Mild_Cognitive_Impairment?f_ri=8971","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9821" href="https://www.academia.edu/Documents/in/Brazil">Brazil</a><script data-card-contents-for-ri="9821" type="text/json">{"id":9821,"name":"Brazil","url":"https://www.academia.edu/Documents/in/Brazil?f_ri=8971","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=45413088]'), work: {"id":45413088,"title":"Development, validity, and reliability of the General Activities of Daily Living Scale: a multidimensional measure of activities of daily living for older people","created_at":"2021-03-07T10:35:22.443-08:00","url":"https://www.academia.edu/45413088/Development_validity_and_reliability_of_the_General_Activities_of_Daily_Living_Scale_a_multidimensional_measure_of_activities_of_daily_living_for_older_people?f_ri=8971","dom_id":"work_45413088","summary":null,"downloadable_attachments":[{"id":65928839,"asset_id":45413088,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":25157637,"first_name":"Edgar","last_name":"Nunes de Moraes","domain_name":"independent","page_name":"EdgarNunesdeMoraes","display_name":"Edgar Nunes de Moraes","profile_url":"https://independent.academia.edu/EdgarNunesdeMoraes?f_ri=8971","photo":"https://0.academia-photos.com/25157637/18859002/39984244/s65_edgar.nunes_de_moraes.jpeg"}],"research_interests":[{"id":2599,"name":"Psychometrics","url":"https://www.academia.edu/Documents/in/Psychometrics?f_ri=8971","nofollow":false},{"id":3243,"name":"Nonparametric Statistics","url":"https://www.academia.edu/Documents/in/Nonparametric_Statistics?f_ri=8971","nofollow":false},{"id":8971,"name":"Mild Cognitive Impairment","url":"https://www.academia.edu/Documents/in/Mild_Cognitive_Impairment?f_ri=8971","nofollow":false},{"id":9821,"name":"Brazil","url":"https://www.academia.edu/Documents/in/Brazil?f_ri=8971","nofollow":false},{"id":44529,"name":"Activities of Daily Living","url":"https://www.academia.edu/Documents/in/Activities_of_Daily_Living?f_ri=8971"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=8971"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female?f_ri=8971"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male?f_ri=8971"},{"id":162159,"name":"Differential Diagnosis","url":"https://www.academia.edu/Documents/in/Differential_Diagnosis?f_ri=8971"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=8971"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=8971"},{"id":295155,"name":"Middle Aged","url":"https://www.academia.edu/Documents/in/Middle_Aged?f_ri=8971"},{"id":327850,"name":"Questionnaires","url":"https://www.academia.edu/Documents/in/Questionnaires?f_ri=8971"},{"id":546419,"name":"Age Factors","url":"https://www.academia.edu/Documents/in/Age_Factors?f_ri=8971"},{"id":549280,"name":"Reproducibility of Results","url":"https://www.academia.edu/Documents/in/Reproducibility_of_Results?f_ri=8971"},{"id":901876,"name":"Sensitivity and Specificity","url":"https://www.academia.edu/Documents/in/Sensitivity_and_Specificity?f_ri=8971"},{"id":1000427,"name":"Reference Values","url":"https://www.academia.edu/Documents/in/Reference_Values?f_ri=8971"},{"id":1120234,"name":"Alzheimer Disease","url":"https://www.academia.edu/Documents/in/Alzheimer_Disease?f_ri=8971"},{"id":2345130,"name":"Socioeconomic Factors","url":"https://www.academia.edu/Documents/in/Socioeconomic_Factors?f_ri=8971"},{"id":2467548,"name":"Neuropsychological Tests","url":"https://www.academia.edu/Documents/in/Neuropsychological_Tests?f_ri=8971"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_14525439" data-work_id="14525439" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/14525439/The_montreal_cognitive_assessment_in_cognitively_intact_elderly_a_case_for_age_adjusted_cutoffs">The montreal cognitive assessment in cognitively-intact elderly: a case for age-adjusted cutoffs</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The Montreal Cognitive Assessment (MoCA) is a widely used screening test for evaluation of mild cognitive impairment (MCI), with a single cutoff for all ages. We examined whether it is associated with age in a sample of cognitively-intact... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_14525439" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The Montreal Cognitive Assessment (MoCA) is a widely used screening test for evaluation of mild cognitive impairment (MCI), with a single cutoff for all ages. We examined whether it is associated with age in a sample of cognitively-intact elderly (CIE). The average MoCA score was negatively correlated with age and was significantly higher for younger than older CIE. Additionally, 42% of the older elderly fell below the proposed MCI cutoff score, although all subjects were CIE. Thus, cognitive abilities captured by the MoCA test decrease with age, even in CIE. Therefore, cutoff scores by age for the MoCA are needed.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/14525439" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="f368730c7cf4491e766d05249c1fdefb" rel="nofollow" data-download="{"attachment_id":44091794,"asset_id":14525439,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44091794/download_file?st=MTczMjQ0MDMyNCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33481981" href="https://telaviv.academia.edu/NirGiladi">Nir Giladi</a><script data-card-contents-for-user="33481981" type="text/json">{"id":33481981,"first_name":"Nir","last_name":"Giladi","domain_name":"telaviv","page_name":"NirGiladi","display_name":"Nir Giladi","profile_url":"https://telaviv.academia.edu/NirGiladi?f_ri=8971","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_14525439 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="14525439"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 14525439, container: ".js-paper-rank-work_14525439", }); });</script></li><li class="js-percentile-work_14525439 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14525439; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_14525439"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_14525439 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="14525439"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14525439; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14525439]").text(description); $(".js-view-count-work_14525439").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_14525439").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="14525439"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">12</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="237" href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a>, <script data-card-contents-for-ri="237" type="text/json">{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=8971","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="6791" href="https://www.academia.edu/Documents/in/Aging">Aging</a>, <script data-card-contents-for-ri="6791" type="text/json">{"id":6791,"name":"Aging","url":"https://www.academia.edu/Documents/in/Aging?f_ri=8971","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="8971" href="https://www.academia.edu/Documents/in/Mild_Cognitive_Impairment">Mild Cognitive Impairment</a>, <script data-card-contents-for-ri="8971" type="text/json">{"id":8971,"name":"Mild Cognitive Impairment","url":"https://www.academia.edu/Documents/in/Mild_Cognitive_Impairment?f_ri=8971","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="64568" href="https://www.academia.edu/Documents/in/Humans">Humans</a><script data-card-contents-for-ri="64568" type="text/json">{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=8971","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=14525439]'), work: {"id":14525439,"title":"The montreal cognitive assessment in cognitively-intact elderly: a case for age-adjusted cutoffs","created_at":"2015-07-31T00:57:14.514-07:00","url":"https://www.academia.edu/14525439/The_montreal_cognitive_assessment_in_cognitively_intact_elderly_a_case_for_age_adjusted_cutoffs?f_ri=8971","dom_id":"work_14525439","summary":"The Montreal Cognitive Assessment (MoCA) is a widely used screening test for evaluation of mild cognitive impairment (MCI), with a single cutoff for all ages. We examined whether it is associated with age in a sample of cognitively-intact elderly (CIE). The average MoCA score was negatively correlated with age and was significantly higher for younger than older CIE. Additionally, 42% of the older elderly fell below the proposed MCI cutoff score, although all subjects were CIE. Thus, cognitive abilities captured by the MoCA test decrease with age, even in CIE. Therefore, cutoff scores by age for the MoCA are needed.","downloadable_attachments":[{"id":44091794,"asset_id":14525439,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33481981,"first_name":"Nir","last_name":"Giladi","domain_name":"telaviv","page_name":"NirGiladi","display_name":"Nir Giladi","profile_url":"https://telaviv.academia.edu/NirGiladi?f_ri=8971","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=8971","nofollow":false},{"id":6791,"name":"Aging","url":"https://www.academia.edu/Documents/in/Aging?f_ri=8971","nofollow":false},{"id":8971,"name":"Mild Cognitive Impairment","url":"https://www.academia.edu/Documents/in/Mild_Cognitive_Impairment?f_ri=8971","nofollow":false},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=8971","nofollow":false},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female?f_ri=8971"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male?f_ri=8971"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=8971"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=8971"},{"id":295155,"name":"Middle Aged","url":"https://www.academia.edu/Documents/in/Middle_Aged?f_ri=8971"},{"id":546419,"name":"Age Factors","url":"https://www.academia.edu/Documents/in/Age_Factors?f_ri=8971"},{"id":1000427,"name":"Reference Values","url":"https://www.academia.edu/Documents/in/Reference_Values?f_ri=8971"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=8971"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_20707623" data-work_id="20707623" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/20707623/Current_epidemiology_of_mild_cognitive_impairment_and_other_predementia_syndromes">Current epidemiology of mild cognitive impairment and other predementia syndromes</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">A variety of clinically-defined predementia syndromes, with differing diagnostic criteria and nomenclature, have been proposed to describe nondisabling symptomatic cognitive deficits arising in elderly persons. Incidence and prevalence of... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_20707623" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">A variety of clinically-defined predementia syndromes, with differing diagnostic criteria and nomenclature, have been proposed to describe nondisabling symptomatic cognitive deficits arising in elderly persons. Incidence and prevalence of different predementia syndromes vary as a result of different diagnostic criteria, sampling, and assessment procedures. The incidence rates of all predementia syndromes increase with age and are higher in subjects with less education; but age, educational background, and gender are not consistently related to prevalence rates. There is particular interest in &quot;Mild Cognitive Impairment (MCI)&quot; because this predementia syndrome is thought to be a prodromal phase of Alzheimer disease (AD). Several studies have suggested that most patients who meet MCI criteria will progress to AD, but rates of conversion to AD and dementia vary widely among studies. Furthermore, MCI definition is less consistent in population-based studies than clinical studi...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/20707623" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="8f33741cb6f31b7c5ab9a74eff4c8b65" rel="nofollow" data-download="{"attachment_id":41517621,"asset_id":20707623,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/41517621/download_file?st=MTczMjQ0MDMyNCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="42008964" href="https://independent.academia.edu/PanzaF">Francesco Panza</a><script data-card-contents-for-user="42008964" type="text/json">{"id":42008964,"first_name":"Francesco","last_name":"Panza","domain_name":"independent","page_name":"PanzaF","display_name":"Francesco Panza","profile_url":"https://independent.academia.edu/PanzaF?f_ri=8971","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_20707623 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="20707623"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 20707623, container: ".js-paper-rank-work_20707623", }); 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$(".js-view-count[data-work-id=20707623]").text(description); $(".js-view-count-work_20707623").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_20707623").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="20707623"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">15</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="3662" href="https://www.academia.edu/Documents/in/Dementia">Dementia</a>, <script data-card-contents-for-ri="3662" type="text/json">{"id":3662,"name":"Dementia","url":"https://www.academia.edu/Documents/in/Dementia?f_ri=8971","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="8971" href="https://www.academia.edu/Documents/in/Mild_Cognitive_Impairment">Mild Cognitive Impairment</a>, <script data-card-contents-for-ri="8971" type="text/json">{"id":8971,"name":"Mild Cognitive Impairment","url":"https://www.academia.edu/Documents/in/Mild_Cognitive_Impairment?f_ri=8971","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="64568" href="https://www.academia.edu/Documents/in/Humans">Humans</a>, <script data-card-contents-for-ri="64568" type="text/json">{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=8971","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="98925" href="https://www.academia.edu/Documents/in/Female">Female</a><script data-card-contents-for-ri="98925" type="text/json">{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female?f_ri=8971","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=20707623]'), work: {"id":20707623,"title":"Current epidemiology of mild cognitive impairment and other predementia syndromes","created_at":"2016-01-24T09:49:01.830-08:00","url":"https://www.academia.edu/20707623/Current_epidemiology_of_mild_cognitive_impairment_and_other_predementia_syndromes?f_ri=8971","dom_id":"work_20707623","summary":"A variety of clinically-defined predementia syndromes, with differing diagnostic criteria and nomenclature, have been proposed to describe nondisabling symptomatic cognitive deficits arising in elderly persons. Incidence and prevalence of different predementia syndromes vary as a result of different diagnostic criteria, sampling, and assessment procedures. The incidence rates of all predementia syndromes increase with age and are higher in subjects with less education; but age, educational background, and gender are not consistently related to prevalence rates. There is particular interest in \u0026quot;Mild Cognitive Impairment (MCI)\u0026quot; because this predementia syndrome is thought to be a prodromal phase of Alzheimer disease (AD). Several studies have suggested that most patients who meet MCI criteria will progress to AD, but rates of conversion to AD and dementia vary widely among studies. Furthermore, MCI definition is less consistent in population-based studies than clinical studi...","downloadable_attachments":[{"id":41517621,"asset_id":20707623,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":42008964,"first_name":"Francesco","last_name":"Panza","domain_name":"independent","page_name":"PanzaF","display_name":"Francesco Panza","profile_url":"https://independent.academia.edu/PanzaF?f_ri=8971","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":3662,"name":"Dementia","url":"https://www.academia.edu/Documents/in/Dementia?f_ri=8971","nofollow":false},{"id":8971,"name":"Mild Cognitive 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href="https://www.academia.edu/16815966/Discrimination_between_Alzheimers_disease_mild_cognitive_impairment_and_normal_aging_by_using_automated_segmentation_of_the_hippocampus">Discrimination between Alzheimer's disease, mild cognitive impairment and normal aging by using automated segmentation of the hippocampus</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/16815966" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="bcce412b67f18243e66d357641ff086d" rel="nofollow" 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type="text/json">{"id":8971,"name":"Mild Cognitive Impairment","url":"https://www.academia.edu/Documents/in/Mild_Cognitive_Impairment?f_ri=8971","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="1663382" href="https://www.academia.edu/Documents/in/Normal_Aging">Normal Aging</a><script data-card-contents-for-ri="1663382" type="text/json">{"id":1663382,"name":"Normal Aging","url":"https://www.academia.edu/Documents/in/Normal_Aging?f_ri=8971","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=16815966]'), work: {"id":16815966,"title":"Discrimination between Alzheimer's disease, mild cognitive impairment and normal aging by using automated segmentation of the 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Impairment","url":"https://www.academia.edu/Documents/in/Mild_Cognitive_Impairment?f_ri=8971","nofollow":false},{"id":1663382,"name":"Normal Aging","url":"https://www.academia.edu/Documents/in/Normal_Aging?f_ri=8971","nofollow":false}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_25672266" data-work_id="25672266" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/25672266/Semantic_Memory_Impairment_in_the_Earliest_Phases_of_Alzheimer_and_rsquo_s_Disease">Semantic Memory Impairment in the Earliest Phases of Alzheimer&rsquo;s Disease</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a 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window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=25672266]").text(description); $(".js-view-count-work_25672266").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_25672266").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="25672266"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">25</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="237" href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a>, <script data-card-contents-for-ri="237" type="text/json">{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=8971","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="2349" href="https://www.academia.edu/Documents/in/Semantics">Semantics</a>, <script data-card-contents-for-ri="2349" type="text/json">{"id":2349,"name":"Semantics","url":"https://www.academia.edu/Documents/in/Semantics?f_ri=8971","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="2599" href="https://www.academia.edu/Documents/in/Psychometrics">Psychometrics</a>, <script data-card-contents-for-ri="2599" type="text/json">{"id":2599,"name":"Psychometrics","url":"https://www.academia.edu/Documents/in/Psychometrics?f_ri=8971","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="8971" href="https://www.academia.edu/Documents/in/Mild_Cognitive_Impairment">Mild Cognitive Impairment</a><script data-card-contents-for-ri="8971" type="text/json">{"id":8971,"name":"Mild Cognitive 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Rationale and Potential Mechanisms</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Serotonin 2A receptor (5-HT2AR) agonist “classic psychedelics” are drawing increasing interest as potential mental health treatments. Recent work suggests psychedelics can exert persisting anxiolytic and antidepressant effects lasting up... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_61070838" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Serotonin 2A receptor (5-HT2AR) agonist “classic psychedelics” are drawing increasing interest as potential mental health treatments. Recent work suggests psychedelics can exert persisting anxiolytic and antidepressant effects lasting up to several months after a single administration. Data indicate acute subjective drug effects as important psychological factors involved in observed therapeutic benefits. Additionally, animal models have shown an important role for 5-HT2AR agonists in modulating learning and memory function with relevance for Alzheimer’s Disease (AD) and related dementias. A number of biological mechanisms of action are under investigation to elucidate 5-HT2AR agonists’ therapeutic potential, including enhanced neuroplasticity, anti-inflammatory effects, and alterations in brain functional connectivity. These diverse lines of research are reviewed here along with a discussion of AD pathophysiology and neuropsychiatric symptoms to highlight classic psychedelics as potential novel pharmacotherapies for patients with AD. Human clinical research suggests a possible role for high-dose psychedelic administration in symptomatic treatment of depressed mood and anxiety in early-stage AD. Preclinical data indicate a potential for low- or high-dose psychedelic treatment regimens to slow or reverse brain atrophy, enhance cognitive function, and slow progression of AD. In conclusion, rationale and potential approaches for preliminary research with psychedelics in patients with AD are presented, and ramifications of this line of investigation for development of novel AD treatments are discussed.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/61070838" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="be3621f5a4d5833caad1b9a8fa667433" rel="nofollow" data-download="{"attachment_id":74239831,"asset_id":61070838,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/74239831/download_file?st=MTczMjQ0MDMyNCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="4176316" href="https://jhusom.academia.edu/AlbertGarcia">Albert Garcia-Romeu, PhD</a><script data-card-contents-for-user="4176316" type="text/json">{"id":4176316,"first_name":"Albert","last_name":"Garcia-Romeu, PhD","domain_name":"jhusom","page_name":"AlbertGarcia","display_name":"Albert Garcia-Romeu, PhD","profile_url":"https://jhusom.academia.edu/AlbertGarcia?f_ri=8971","photo":"https://0.academia-photos.com/4176316/1633406/2229334/s65_albert.garcia.jpg"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-61070838">+2</span><div class="hidden js-additional-users-61070838"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://johnshopkins.academia.edu/SeanDarcy">Sean Darcy</a></span></div><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/TONIWHITE9">TONI WHITE</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-61070838'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-61070838').html(); 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Human clinical research suggests a possible role for high-dose psychedelic administration in symptomatic treatment of depressed mood and anxiety in early-stage AD. Preclinical data indicate a potential for low- or high-dose psychedelic treatment regimens to slow or reverse brain atrophy, enhance cognitive function, and slow progression of AD. 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itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/35242513/Vitamin_B12_supplementation_and_cognitive_scores_in_geriatric_patients_with_Mild_Cognitive_Impairment">Vitamin B12 supplementation and cognitive scores in geriatric patients with Mild Cognitive Impairment</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: The Neurodegenerative diseases are increasingly affecting the elderly with a severe impact on their brain health. There is a wide gap in supplementation based studies for increasing the cognition levels of the geriatric... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_35242513" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: The Neurodegenerative diseases are increasingly affecting the elderly with a severe impact on their brain health. There is a wide gap in supplementation based studies for increasing the cognition levels of the geriatric population especially in the developing countries like India, which are at extreme risk of developing neurological disorders. Vitamin B12 herein has caught much attention lately for improving the cognitive status. Literature has linked the possibility of alleviating neurological disorders in the elderly with effective vitamin B12 management. Abundant animal and human models have proved that supplementation of vitamin B12 is beneficial for the restoration of cognitive functions. Objective: To supplement vitamin B12 deficient mild cognitively impaired geriatric patients with injectable doses of vitamin B12 followed by impact evaluation.<br /><br />Methods: Screening of the mild cognitively impaired patients was carried out using the Mini-Mental State Examination and Yamaguchi Fox Pigeon Imitation test. Baseline information was elicited from the patients residing in urban Vadodara (a district in the state of Gujarat), India. This included socio-demographic, medical and drug history, anthropometric and physical activity pattern as well as biochemical parameters comprising of serum vitamin B12 and glycated haemoglobin profile. A sub-sample of 60 patients with mild cognitive impairment (MCI) demonstrating severe vitamin B12 deficiency were conveniently enrolled for injectable doses of Vitamin B12 in the dosage of 1,000 μg every day for one week, followed by 1,000 μg every week for 4 weeks & finishing with 1,000 μg for the remaining 4 months. Post six months intervention all the parameters were elicited.<br /><br />Results: Vitamin B12 supplementation resulted in a significant (p<0.001) improvement in the MMSE scores of the patients with a rise of 9.63% in the total patients. Gender-wise division also highlighted a significant increase (p<0.001) in the scores by 6.79% and 12.46% in overall males and females and a 10.20% and 8.24% rise for young-old (60-69 yrs) and old- old (70-85 yrs) categories, respectively. As a result, 27 patients progressed towards the category from the MCI state being assessed by MMSE scores. In the same manner, YGFPIT too demonstrated a 38% increase in normal with 35% males, 42% females, 41% young–old and 31% old-old moving to normal status. Thus, a total number of 28 patients progressed to the normal condition as per YGFPIT.<br /><br />Conclusion: Hence, vitamin B12 supplementation was found significantly effective in placing the serum vitamin B12 of MCI patients from the deficiency state to sufficient levels and in turn increased their performance in MMSE and YFPIT scores.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/35242513" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="08f6620f1d7da6c347ea20121f6b9dd8" rel="nofollow" data-download="{"attachment_id":55101888,"asset_id":35242513,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/55101888/download_file?st=MTczMjQ0MDMyNCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="71697658" href="https://independent.academia.edu/MartirosyanDanik">Food Science Publisher</a><script data-card-contents-for-user="71697658" type="text/json">{"id":71697658,"first_name":"Food Science","last_name":"Publisher","domain_name":"independent","page_name":"MartirosyanDanik","display_name":"Food Science Publisher","profile_url":"https://independent.academia.edu/MartirosyanDanik?f_ri=8971","photo":"https://0.academia-photos.com/71697658/43007818/34320184/s65_food_science.publisher.jpg"}</script></span></span></li><li class="js-paper-rank-work_35242513 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="35242513"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 35242513, container: ".js-paper-rank-work_35242513", }); 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There is a wide gap in supplementation based studies for increasing the cognition levels of the geriatric population especially in the developing countries like India, which are at extreme risk of developing neurological disorders. Vitamin B12 herein has caught much attention lately for improving the cognitive status. Literature has linked the possibility of alleviating neurological disorders in the elderly with effective vitamin B12 management. Abundant animal and human models have proved that supplementation of vitamin B12 is beneficial for the restoration of cognitive functions. Objective: To supplement vitamin B12 deficient mild cognitively impaired geriatric patients with injectable doses of vitamin B12 followed by impact evaluation.\n\nMethods: Screening of the mild cognitively impaired patients was carried out using the Mini-Mental State Examination and Yamaguchi Fox Pigeon Imitation test. Baseline information was elicited from the patients residing in urban Vadodara (a district in the state of Gujarat), India. This included socio-demographic, medical and drug history, anthropometric and physical activity pattern as well as biochemical parameters comprising of serum vitamin B12 and glycated haemoglobin profile. A sub-sample of 60 patients with mild cognitive impairment (MCI) demonstrating severe vitamin B12 deficiency were conveniently enrolled for injectable doses of Vitamin B12 in the dosage of 1,000 μg every day for one week, followed by 1,000 μg every week for 4 weeks \u0026 finishing with 1,000 μg for the remaining 4 months. Post six months intervention all the parameters were elicited.\n\nResults: Vitamin B12 supplementation resulted in a significant (p\u003c0.001) improvement in the MMSE scores of the patients with a rise of 9.63% in the total patients. Gender-wise division also highlighted a significant increase (p\u003c0.001) in the scores by 6.79% and 12.46% in overall males and females and a 10.20% and 8.24% rise for young-old (60-69 yrs) and old- old (70-85 yrs) categories, respectively. As a result, 27 patients progressed towards the category from the MCI state being assessed by MMSE scores. In the same manner, YGFPIT too demonstrated a 38% increase in normal with 35% males, 42% females, 41% young–old and 31% old-old moving to normal status. Thus, a total number of 28 patients progressed to the normal condition as per YGFPIT.\n\nConclusion: Hence, vitamin B12 supplementation was found significantly effective in placing the serum vitamin B12 of MCI patients from the deficiency state to sufficient levels and in turn increased their performance in MMSE and YFPIT scores. 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cognitive impairment elderly with different bdnf Val66Met genotypes</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The benefits of physical exercise on improvements in brain-derived neurotrophic factor (BDNF) levels and cognitive functioning have been reported in the literature. However, the variability of individual responses may be linked to genetic... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_14938348" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The benefits of physical exercise on improvements in brain-derived neurotrophic factor (BDNF) levels and cognitive functioning have been reported in the literature. However, the variability of individual responses may be linked to genetic differences. BDNF is considered one of the most plausible factors involved in the cognitive benefits associated with physical activity practice. A single nucleotide polymorphism localized in the gene that codes BDNF results in a missense mutation that promotes an amino acid substitution (Val66Met) in the protein. This process has been associated with decreased levels of BDNF secretion, with corresponding impairments in specific cognitive functions. Therefore, the objective of this study was to analyze the effects of a multimodal physical exercise program on peripheral BDNF levels and cognitive functions in elderly individuals with mild cognitive impairment (MCI). The participants were genotyped for the BDNF Val66Met polymorphism. Cognitive function...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/14938348" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="81bfd42be0f7c6dd76e6767dba014979" rel="nofollow" data-download="{"attachment_id":43730990,"asset_id":14938348,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/43730990/download_file?st=MTczMjQ0MDMyNCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33930659" href="https://ufscar.academia.edu/M%C3%A1rciaCominetti">Márcia R Cominetti</a><script data-card-contents-for-user="33930659" type="text/json">{"id":33930659,"first_name":"Márcia","last_name":"Cominetti","domain_name":"ufscar","page_name":"MárciaCominetti","display_name":"Márcia R Cominetti","profile_url":"https://ufscar.academia.edu/M%C3%A1rciaCominetti?f_ri=8971","photo":"https://0.academia-photos.com/33930659/9976185/11125478/s65_m_rcia.cominetti.jpg"}</script></span></span></li><li class="js-paper-rank-work_14938348 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="14938348"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 14938348, container: ".js-paper-rank-work_14938348", }); 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href="https://www.academia.edu/74862114/The_Association_Between_Mild_Cognitive_Impairment_and_Self_care_in_Adults_With_Chronic_Heart_Failure">The Association Between Mild Cognitive Impairment and Self-care in Adults With Chronic Heart Failure</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/74862114" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="89cc0bb26e7c67c9f0d0e9c1daa517d4" rel="nofollow" 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InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="3266825"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 3266825; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=3266825]").text(description); $(".js-view-count-work_3266825").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_3266825").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="3266825"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">7</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="8971" href="https://www.academia.edu/Documents/in/Mild_Cognitive_Impairment">Mild Cognitive Impairment</a>, <script data-card-contents-for-ri="8971" type="text/json">{"id":8971,"name":"Mild Cognitive Impairment","url":"https://www.academia.edu/Documents/in/Mild_Cognitive_Impairment?f_ri=8971","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9112" href="https://www.academia.edu/Documents/in/Physical_Activity">Physical Activity</a>, <script data-card-contents-for-ri="9112" type="text/json">{"id":9112,"name":"Physical Activity","url":"https://www.academia.edu/Documents/in/Physical_Activity?f_ri=8971","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="64568" href="https://www.academia.edu/Documents/in/Humans">Humans</a>, <script data-card-contents-for-ri="64568" type="text/json">{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=8971","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="244814" href="https://www.academia.edu/Documents/in/Clinical_Sciences">Clinical Sciences</a><script data-card-contents-for-ri="244814" type="text/json">{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=8971","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=3266825]'), work: {"id":3266825,"title":"Non-pharmacological interventions on cognitive functions in older people with mild cognitive impairment (MCI)","created_at":"2013-04-11T12:45:53.801-07:00","url":"https://www.academia.edu/3266825/Non_pharmacological_interventions_on_cognitive_functions_in_older_people_with_mild_cognitive_impairment_MCI_?f_ri=8971","dom_id":"work_3266825","summary":null,"downloadable_attachments":[{"id":50384326,"asset_id":3266825,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":3760950,"first_name":"Danilla","last_name":"Corazza","domain_name":"unesp","page_name":"DanillaCorazza","display_name":"Danilla Corazza","profile_url":"https://unesp.academia.edu/DanillaCorazza?f_ri=8971","photo":"https://0.academia-photos.com/3760950/1357822/3624527/s65_danilla.corazza.jpg"}],"research_interests":[{"id":8971,"name":"Mild Cognitive Impairment","url":"https://www.academia.edu/Documents/in/Mild_Cognitive_Impairment?f_ri=8971","nofollow":false},{"id":9112,"name":"Physical Activity","url":"https://www.academia.edu/Documents/in/Physical_Activity?f_ri=8971","nofollow":false},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=8971","nofollow":false},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=8971","nofollow":false},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=8971"},{"id":295155,"name":"Middle Aged","url":"https://www.academia.edu/Documents/in/Middle_Aged?f_ri=8971"},{"id":2307180,"name":"Systemic Review","url":"https://www.academia.edu/Documents/in/Systemic_Review?f_ri=8971"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_11347077" data-work_id="11347077" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/11347077/Clinical_associations_of_anosognosia_in_mild_cognitive_impairment_and_Alzheimers_disease">Clinical associations of anosognosia in mild cognitive impairment and Alzheimer's disease</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Aims and objective: While loss of insight of cognitive deficits is a common phenomenon in patients with Alzheimer’s disease (AD), there is a lack of consensus regarding the presence of impaired insight among patients with mild cognitive... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_11347077" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Aims and objective: While loss of insight of cognitive deficits is a common phenomenon in patients with Alzheimer’s disease (AD), there is a lack of consensus regarding the presence of impaired insight among patients with mild cognitive impairment (MCI). We aim to investigate the clinical, cognitive, and be- havioral associations of anosognosia in AD and MCI subjects. <br />Methods: A consecutive series of 87 subjects (30 healthy older patients, 21 MCI, and 36 AD) each ac- companied by a caregiver, underwent clinical assessment including the evaluation of insight using the Anosognosia Questionnaire for Dementia (AQD). We also separately assessed Intellectual Function (AQD-IF) and Behavior domains of the AQD scale. Regression models were subsequently used to inves- tigate associations of AQD scores with cognitive and other neuropsychiatric symptoms, including de- pression and apathy. <br />Results: Both AD and MCI groups demonstrated significant anosognosia compared with the healthy control group. In the AD group, 55.6% had “Mild Anosognosia,” and 27.8% had “Severe Anosognosia.” In the MCI group, 42.9% showed “Mild Anosognosia,” and 9.5% had “Severe Anosognosia.” Greater levels of AQD-Total and AQD-IF were associated with lower Mini-mental state examination and higher apathy scores in the AD group. In the MCI group, caregiver burden was significantly associated with AQD-Total (p = 0.016) and AQD-IF (p = 0.039). <br />Conclusion: The results indicated that anosognosia is common in both AD and MCI patients and asso- ciated with cognitive dysfunction and apathy in AD. The findings of this study warrant further research to delineate the mechanisms of anosognosia as it poses a challenge to treatment outcomes.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/11347077" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="d60ef4cf9bae8cc6b0a67f4d7a9c74a2" rel="nofollow" data-download="{"attachment_id":36918760,"asset_id":11347077,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/36918760/download_file?st=MTczMjQ0MDMyNCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="21800175" href="https://imh.academia.edu/RowenaChin">Rowena Chin</a><script data-card-contents-for-user="21800175" type="text/json">{"id":21800175,"first_name":"Rowena","last_name":"Chin","domain_name":"imh","page_name":"RowenaChin","display_name":"Rowena Chin","profile_url":"https://imh.academia.edu/RowenaChin?f_ri=8971","photo":"https://0.academia-photos.com/21800175/5987912/6795014/s65_rowena.chin.jpg_oh_03facc892f62b700ea896cf98be0af15_oe_54e03f9f___gda___1423907914_859304ca019ee116d38be3231e681f18"}</script></span></span></li><li class="js-paper-rank-work_11347077 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="11347077"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 11347077, container: ".js-paper-rank-work_11347077", }); 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$(".js-view-count[data-work-id=11347077]").text(description); $(".js-view-count-work_11347077").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_11347077").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="11347077"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">9</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="251" href="https://www.academia.edu/Documents/in/Neuropsychology">Neuropsychology</a>, <script data-card-contents-for-ri="251" type="text/json">{"id":251,"name":"Neuropsychology","url":"https://www.academia.edu/Documents/in/Neuropsychology?f_ri=8971","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="623" href="https://www.academia.edu/Documents/in/Neurology">Neurology</a>, <script data-card-contents-for-ri="623" type="text/json">{"id":623,"name":"Neurology","url":"https://www.academia.edu/Documents/in/Neurology?f_ri=8971","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="3662" href="https://www.academia.edu/Documents/in/Dementia">Dementia</a>, <script data-card-contents-for-ri="3662" type="text/json">{"id":3662,"name":"Dementia","url":"https://www.academia.edu/Documents/in/Dementia?f_ri=8971","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="3776" href="https://www.academia.edu/Documents/in/Alzheimers_Disease">Alzheimer's Disease</a><script data-card-contents-for-ri="3776" type="text/json">{"id":3776,"name":"Alzheimer's Disease","url":"https://www.academia.edu/Documents/in/Alzheimers_Disease?f_ri=8971","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=11347077]'), work: {"id":11347077,"title":"Clinical associations of anosognosia in mild cognitive impairment and Alzheimer's disease","created_at":"2015-03-09T22:09:16.425-07:00","url":"https://www.academia.edu/11347077/Clinical_associations_of_anosognosia_in_mild_cognitive_impairment_and_Alzheimers_disease?f_ri=8971","dom_id":"work_11347077","summary":"Aims and objective: While loss of insight of cognitive deficits is a common phenomenon in patients with Alzheimer’s disease (AD), there is a lack of consensus regarding the presence of impaired insight among patients with mild cognitive impairment (MCI). We aim to investigate the clinical, cognitive, and be- havioral associations of anosognosia in AD and MCI subjects.\r\nMethods: A consecutive series of 87 subjects (30 healthy older patients, 21 MCI, and 36 AD) each ac- companied by a caregiver, underwent clinical assessment including the evaluation of insight using the Anosognosia Questionnaire for Dementia (AQD). We also separately assessed Intellectual Function (AQD-IF) and Behavior domains of the AQD scale. Regression models were subsequently used to inves- tigate associations of AQD scores with cognitive and other neuropsychiatric symptoms, including de- pression and apathy.\r\nResults: Both AD and MCI groups demonstrated significant anosognosia compared with the healthy control group. In the AD group, 55.6% had “Mild Anosognosia,” and 27.8% had “Severe Anosognosia.” In the MCI group, 42.9% showed “Mild Anosognosia,” and 9.5% had “Severe Anosognosia.” Greater levels of AQD-Total and AQD-IF were associated with lower Mini-mental state examination and higher apathy scores in the AD group. In the MCI group, caregiver burden was significantly associated with AQD-Total (p = 0.016) and AQD-IF (p = 0.039).\r\nConclusion: The results indicated that anosognosia is common in both AD and MCI patients and asso- ciated with cognitive dysfunction and apathy in AD. The findings of this study warrant further research to delineate the mechanisms of anosognosia as it poses a challenge to treatment outcomes. ","downloadable_attachments":[{"id":36918760,"asset_id":11347077,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":21800175,"first_name":"Rowena","last_name":"Chin","domain_name":"imh","page_name":"RowenaChin","display_name":"Rowena Chin","profile_url":"https://imh.academia.edu/RowenaChin?f_ri=8971","photo":"https://0.academia-photos.com/21800175/5987912/6795014/s65_rowena.chin.jpg_oh_03facc892f62b700ea896cf98be0af15_oe_54e03f9f___gda___1423907914_859304ca019ee116d38be3231e681f18"}],"research_interests":[{"id":251,"name":"Neuropsychology","url":"https://www.academia.edu/Documents/in/Neuropsychology?f_ri=8971","nofollow":false},{"id":623,"name":"Neurology","url":"https://www.academia.edu/Documents/in/Neurology?f_ri=8971","nofollow":false},{"id":3662,"name":"Dementia","url":"https://www.academia.edu/Documents/in/Dementia?f_ri=8971","nofollow":false},{"id":3776,"name":"Alzheimer's Disease","url":"https://www.academia.edu/Documents/in/Alzheimers_Disease?f_ri=8971","nofollow":false},{"id":4212,"name":"Cognition","url":"https://www.academia.edu/Documents/in/Cognition?f_ri=8971"},{"id":8971,"name":"Mild Cognitive Impairment","url":"https://www.academia.edu/Documents/in/Mild_Cognitive_Impairment?f_ri=8971"},{"id":33733,"name":"Cognitive Aging","url":"https://www.academia.edu/Documents/in/Cognitive_Aging?f_ri=8971"},{"id":114061,"name":"Anosognosia","url":"https://www.academia.edu/Documents/in/Anosognosia?f_ri=8971"},{"id":274285,"name":"Geriatric Psychiatry","url":"https://www.academia.edu/Documents/in/Geriatric_Psychiatry?f_ri=8971"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_17172073" data-work_id="17172073" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/17172073/Clinical_Interview_Assessment_of_Financial_Capacity_in_Older_Adults_with_Mild_Cognitive_Impairment_and_Alzheimers_Disease">Clinical Interview Assessment of Financial Capacity in Older Adults with Mild Cognitive Impairment and Alzheimer's Disease</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/17172073" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="d6512c5854db5447e2ed75a03c6f210f" rel="nofollow" data-download="{"attachment_id":39377126,"asset_id":17172073,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/39377126/download_file?st=MTczMjQ0MDMyNCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="36771308" href="https://independent.academia.edu/RoyMartin14">Roy Martin</a><script data-card-contents-for-user="36771308" type="text/json">{"id":36771308,"first_name":"Roy","last_name":"Martin","domain_name":"independent","page_name":"RoyMartin14","display_name":"Roy Martin","profile_url":"https://independent.academia.edu/RoyMartin14?f_ri=8971","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_17172073 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="17172073"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 17172073, container: ".js-paper-rank-work_17172073", }); });</script></li><li class="js-percentile-work_17172073 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17172073; 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type="text/json">{"id":7736,"name":"Attention","url":"https://www.academia.edu/Documents/in/Attention?f_ri=8971","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="8971" href="https://www.academia.edu/Documents/in/Mild_Cognitive_Impairment">Mild Cognitive Impairment</a>, <script data-card-contents-for-ri="8971" type="text/json">{"id":8971,"name":"Mild Cognitive Impairment","url":"https://www.academia.edu/Documents/in/Mild_Cognitive_Impairment?f_ri=8971","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="44529" href="https://www.academia.edu/Documents/in/Activities_of_Daily_Living">Activities of Daily Living</a><script data-card-contents-for-ri="44529" type="text/json">{"id":44529,"name":"Activities of Daily Living","url":"https://www.academia.edu/Documents/in/Activities_of_Daily_Living?f_ri=8971","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: 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