CINXE.COM

<!DOCTYPE html> <html lang="en" class="theme_DF"><head> <meta name="viewport" content="width=device-width, initial-scale=1"> <base href="/"> <link rel="search" type="application/opensearchdescription+xml" title="PDBj Search" href="./pdbj_search.xml" /><script>window.fromStatic=true; window.newweb = {call: function(a,b,c) {setTimeout(function(){newweb.call(a,b,c);}, 100)}}; function importNewweb(a,b) {setTimeout(function() {importNewweb(a,b);}, 100);}</script><link rel="icon" type="image/png" sizes="16x16" href="./newweb/media/icons/favicon16.png"><link rel="icon" type="image/png" sizes="32x32" href="./newweb/media/icons/favicon32.png"><link rel="icon" type="image/png" sizes="64x64" href="./newweb/media/icons/favicon64.png"><link rel="icon" type="image/svg+xml" sizes="any" href="./newweb/media/icons/favicon.svg"><style data-module="core">:root.theme_oldDF{--COLOUR__MAIN:#9DCDC5;--COLOUR__MAIN_MILD:191,223,217;--COLOUR__MAIN_OPPOSITE:#C8323A;--COLOUR__MAIN_BORDER:#BFDFD9;--COLOUR__MAIN_SELECT:#9DCDC5;--COLOUR__MAIN_MILD_SELECT:#E1EFED;--COLOUR__SWITCH_1:#FFFFFF;--COLOUR__SWITCH_2:#F0F1F2;--COLOUR__SWITCH_3:#F5F5F5;--COLOUR__MAIN_ACCENT:#FFFFFF;--COLOUR__BG:#F8F8FC;--COLOUR__TXT:#000000}:root.theme_DF{--COLOUR__MAIN:#9DCDC5;--COLOUR__MAIN_MILD:157,205,173;--COLOUR__MAIN_OPPOSITE:#cd9da5;--COLOUR__MAIN_BORDER:#9dcdad;--COLOUR__MAIN_SELECT:#9DCDC5;--COLOUR__MAIN_MILD_SELECT:#e6f2f1;--COLOUR__SWITCH_1:#FFFFFF;--COLOUR__SWITCH_2:#F0F1F2;--COLOUR__SWITCH_3:#F5F5F5;--COLOUR__MAIN_ACCENT:#FFFFFF;--COLOUR__BG:#F8F8FC;--COLOUR__TXT:#000000}:root.theme_OB{--COLOUR__MAIN:#45A1DE;--COLOUR__MAIN_MILD:198,227,245;--COLOUR__MAIN_OPPOSITE:#C8323A;--COLOUR__MAIN_BORDER:#C6E3F5;--COLOUR__MAIN_SELECT:#45A1DE;--COLOUR__MAIN_MILD_SELECT:#E7F0FF;--COLOUR__SWITCH_1:#FFFFFF;--COLOUR__SWITCH_2:#F0F1F2;--COLOUR__SWITCH_3:#F5F5F5;--COLOUR__MAIN_ACCENT:#FFFFFF;--COLOUR__BG:#F8F8FC;--COLOUR__TXT:#000000}:root.theme_MS{--COLOUR__MAIN:#C0C0C0;--COLOUR__MAIN_MILD:217,217,217;--COLOUR__MAIN_OPPOSITE:#C8323A;--COLOUR__MAIN_BORDER:#BFBFBF;--COLOUR__MAIN_SELECT:#C0C0C0;--COLOUR__MAIN_MILD_SELECT:#FED6D2;--COLOUR__SWITCH_1:#FFFFFF;--COLOUR__SWITCH_2:#F0F1F2;--COLOUR__SWITCH_3:#F5F5F5;--COLOUR__MAIN_ACCENT:#EAEAEA;--COLOUR__BG:#F8F8FC;--COLOUR__TXT:#000000}:root.theme_PG{--COLOUR__MAIN:#C7F3A0;--COLOUR__MAIN_MILD:213,246,184;--COLOUR__MAIN_OPPOSITE:#C8323A;--COLOUR__MAIN_BORDER:#ACED73;--COLOUR__MAIN_SELECT:#C7F3A0;--COLOUR__MAIN_MILD_SELECT:#A1E887;--COLOUR__SWITCH_1:#FFFFFF;--COLOUR__SWITCH_2:#EAEAEA;--COLOUR__SWITCH_3:#F5F5F5;--COLOUR__MAIN_ACCENT:#FFFFFF;--COLOUR__BG:#F8F8FC;--COLOUR__TXT:#000000}:root.theme_PP{--COLOUR__MAIN:#FAE7CA;--COLOUR__MAIN_MILD:255,243,224;--COLOUR__MAIN_OPPOSITE:#C8323A;--COLOUR__MAIN_BORDER:#FFDEAD;--COLOUR__MAIN_SELECT:#FAE7CA;--COLOUR__MAIN_MILD_SELECT:#FFF3E0;--COLOUR__SWITCH_1:#FFFFFF;--COLOUR__SWITCH_2:#EAEAEA;--COLOUR__SWITCH_3:#F5F5F5;--COLOUR__MAIN_ACCENT:#FFFFFF;--COLOUR__BG:#F8F8FC;--COLOUR__TXT:#000000}:root.theme_GD{--COLOUR__MAIN:#F3E472;--COLOUR__MAIN_MILD:247,237,161;--COLOUR__MAIN_OPPOSITE:#C8323A;--COLOUR__MAIN_BORDER:#EFDB43;--COLOUR__MAIN_SELECT:#F3E472;--COLOUR__MAIN_MILD_SELECT:#F7EDA1;--COLOUR__SWITCH_1:#FFFFFF;--COLOUR__SWITCH_2:#EAEAEA;--COLOUR__SWITCH_3:#F5F5F5;--COLOUR__MAIN_ACCENT:#FFFFFF;--COLOUR__BG:#F8F8FC;--COLOUR__TXT:#000000}:root.theme_RD{--COLOUR__MAIN:#EB7647;--COLOUR__MAIN_MILD:242,169,140;--COLOUR__MAIN_OPPOSITE:#45A1DE;--COLOUR__MAIN_BORDER:#F2A98C;--COLOUR__MAIN_SELECT:#EB7647;--COLOUR__MAIN_MILD_SELECT:#F2A98C;--COLOUR__SWITCH_1:#FFFFFF;--COLOUR__SWITCH_2:#EAEAEA;--COLOUR__SWITCH_3:#F5F5F5;--COLOUR__MAIN_ACCENT:#FFFFFF;--COLOUR__BG:#F8F8FC;--COLOUR__TXT:#000000}:root.theme_DK{--COLOUR__MAIN:#404040;--COLOUR__MAIN_MILD:8,8,8;--COLOUR__MAIN_OPPOSITE:#cd9da5;--COLOUR__MAIN_BORDER:#303030;--COLOUR__MAIN_SELECT:#404040;--COLOUR__MAIN_MILD_SELECT:#190D0E;--COLOUR__SWITCH_1:#000000;--COLOUR__SWITCH_2:#0F0E0D;--COLOUR__SWITCH_3:#190D0E;--COLOUR__MAIN_ACCENT:#202020;--COLOUR__BG:#000000;--COLOUR__TXT:#FFFFFF}@media only screen and (min-width:75em){header{width:67%;left:16.5%}nav{width:15.25%;display:inline-block}#pageDIV>div{width:67%;left:16.5%}aside{position:absolute;right:-25%;top:0;width:22.8%;margin-right:1.1%}header>:first-child>:nth-child(4)>:nth-child(1){display:none}}@media only screen and (max-width:75em){nav{width:24%;display:inline-block}header{left:.5%}header:after{left:.5%}#pageDIV>div{left:.5%}}@media only screen and (min-width:40.001em){header{height:10.5em}nav{top:11.5em}#pageDIV>div{top:11.5em}aside{z-index:10}}@media only screen and (max-width:40em){aside{max-width:15em;margin:0 auto}}@media only screen and (min-width:40.001em) and (max-width:75em){header{width:74.5%}#pageDIV>div{width:74.5%}nav{width:25%;min-width:25em;display:none;z-index:999}aside{position:absolute;right:-34%;top:0;width:32%;margin-right:1.1%}}@media only screen and (max-width:40em){header{width:99%;left:.5%;height:8em}header:after{height:8em}#pageDIV>div{width:99%;left:.5%;top:9em}nav{top:9em;width:50%;display:none;z-index:999}header>:first-child>:nth-child(4)>:nth-child(1){display:inline-block}}@media only screen and (max-width:15em){nav{width:100%!important}}.no_contentMenu aside{visibility:hidden;opacity:0}@media only screen and (min-width:75em){.no_contentMenu header{width:82.5%}.no_contentMenu #pageDIV>div{width:82.5%}}@media only screen and (min-width:40.001em) and (max-width:75em){.no_contentMenu header{width:99%}.no_contentMenu #pageDIV>div{width:99%}}.minimalDisplay header{display:none}.minimalDisplay nav{display:none}.minimalDisplay aside{display:none}.minimalDisplay #pageDIV>div{min-width:99%;width:auto;left:.5%;top:1em}html.minimalDisplay{overflow-x:auto!important}html{overflow-y:scroll;font-size:14px;font-family:verdana,meiryo,sans-serif,Arial Unicode MS,Cambria Math;overflow-x:hidden;color:var(--COLOUR__TXT)}body{margin:0;background-color:var(--COLOUR__BG)}input[type=reset],input[type=submit]{font-family:verdana,meiryo,sans-serif,Arial Unicode MS,Cambria Math;font-size:1em}a img{border:none}img{max-width:100%;height:auto}header{position:absolute;z-index:990;top:-.5em;background-image:linear-gradient(var(--COLOUR__MAIN_ACCENT),var(--COLOUR__MAIN));border-bottom-right-radius:1em;border-bottom-left-radius:1em;box-shadow:0 10px 20px rgba(0,0,0,.19),0 6px 6px rgba(0,0,0,.23)}header>:first-child>:nth-child(4){position:absolute;bottom:.67em;left:.5em}@media only screen and (max-width:16em){header>:first-child>:nth-child(4) a{display:none}header>:first-child>:nth-child(4){right:0;left:auto}}@media only screen and (max-width:11em){header>:first-child>:nth-child(4)>span>span{display:none}}#pageDIV>div{position:absolute;display:inline-block;z-index:10}table{font-size:1em}figcaption:active{opacity:1!important;-webkit-user-select:none}figcaption:hover{opacity:1!important}figcaption{transition:opacity .3s ease-out;opacity:.33}figcaption{font-style:italic;padding:1em 3em 1em 3em;border-bottom-left-radius:1em;border-bottom-right-radius:1em}header:after{box-shadow:0 10px 20px rgba(0,0,0,.19),0 6px 6px rgba(0,0,0,.23)}figure{border:1px solid var(--COLOUR__MAIN)}figcaption{background-color:rgb(rgb(var(--COLOUR__MAIN_MILD)));color:var(--COLOUR__MAIN_OPPOSITE)}hr.smoothHR{border:0;height:1px;background-image:linear-gradient(to right,var(--COLOUR__MAIN_ACCENT),var(--COLOUR__MAIN),var(--COLOUR__MAIN_ACCENT))}hr.leftHR{border:0;height:1px;background-image:linear-gradient(to right,var(--COLOUR__MAIN),var(--COLOUR__MAIN_ACCENT))}a{color:#00f}a.blackA{color:var(--COLOUR__TXT)}a:hover{color:#c8323a!important}a.A_nomarkup{color:var(--COLOUR__TXT);text-decoration:none}nav{position:absolute;margin-left:.5%}nav ul{margin:0;padding:0;overflow:hidden}nav li{list-style:none;padding:0 0 .5em 1em}nav li:last-child{padding-bottom:0}nav a{text-decoration:none;color:var(--COLOUR__TXT);display:inline-block}figure img{max-width:97.5%;padding:1em}figure{border-radius:1em}header>:first-child{padding-top:.5em}header>:first-child>:nth-child(5) a{color:var(--COLOUR__TXT)}header>:first-child>:nth-child(4) svg{width:2.25em}header>:first-child>:nth-child(4) img,header>:first-child>:nth-child(4) svg{height:2.25em}header>:first-child>:nth-child(4)>:nth-child(6) img{margin-right:.25em}header>:first-child>:nth-child(4) span{display:inline-block;vertical-align:top;margin-top:1.25em;margin-left:.5em;font-weight:700}header>:first-child>:nth-child(4)>:nth-child(5):not(:lang(ja)){display:none}header>:first-child>:nth-child(4)>:nth-child(5) img:lang(ja){margin-right:.1em;margin-left:.0625em;width:auto}header>:first-child>:nth-child(4)>:nth-child(1){margin:0 .5em 0 0;padding:0 .5em 0 0;cursor:pointer}header>:first-child>:nth-child(4)>:nth-child(1) span{position:relative;bottom:.75em}header>:first-child>:nth-child(4)>:nth-child(7) img{width:auto}header>:first-child>:nth-child(4)>:nth-child(8) img{width:auto}@media only screen and (max-width:45em){header>:first-child>:nth-child(4)>:nth-child(6){display:none}}@media only screen and (max-width:72em){header>:first-child>:nth-child(5){display:none}#loginCheck{display:none}}li a{display:inline}footer>div>span img{width:auto;vertical-align:middle;height:3em}@media only screen and (min-width:25em){header>:first-child>:nth-child(5) a{display:inline-block!important}}@media only screen and (max-width:40em){header>:first-child>:nth-child(5){max-width:calc(100% - 24em)!important;right:.5em!important}.wwpdb_foundation_img,.wwpdb_img{display:none}}@media only screen and (max-width:40em){header>:first-child>:nth-child(5){top:5.3125em!important}header>:first-child>:nth-child(2){bottom:.75em;left:18em}header>:first-child>:nth-child(2):lang(ja){left:19em}header>:first-child>:nth-child(2):not(:lang(ja)){left:18em}}@media only screen and (max-width:16em){header>:first-child>:nth-child(4) a{display:none}header>:first-child>:nth-child(2){right:0;left:auto}}@media only screen and (max-width:27em){header{height:9em}#pageDIV>div{top:12em}header>:first-child>:nth-child(5){bottom:-.75em!important;top:initial!important}header:after{height:11em}nav{top:12em!important}}@media only screen and (max-width:11em){header>:first-child>:nth-child(4)>span>span{display:none}}@media only screen and (max-width:21em){header>:first-child>:nth-child(5){display:none}}header>:first-child>:nth-child(2){position:absolute;padding:.5em}@media only screen and (min-width:64.1315em){header>:first-child>:nth-child(2){top:.5em;right:3.5em}header>:first-child>:nth-child(2) .lb_sel{color:#c8323a}header>:first-child>:nth-child(2) .button{display:none}header>:first-child>:nth-child(2)>span{visibility:visible!important;opacity:1!important;display:block}header>:first-child>:nth-child(2) a{cursor:pointer;margin:.25em 0 0 1em;font-size:1.125em}header>:first-child>:nth-child(2) a:nth-child(1):lang(en),header>:first-child>:nth-child(2) a:nth-child(2):lang(ja),header>:first-child>:nth-child(2) a:nth-child(3):lang(zh-CN),header>:first-child>:nth-child(2) a:nth-child(4):lang(zh-TW),header>:first-child>:nth-child(2) a:nth-child(5):lang(ko){color:#c8323a}header>:first-child>:nth-child(2) br{display:none}}@media only screen and (min-width:40.0315em) and (max-width:64.15em){header>:first-child>:nth-child(2){top:.5em;right:3.5em!important}}@media only screen and (max-width:64.15em){header>:first-child>:nth-child(2)>span{border:1px solid var(--COLOUR__MAIN)}header>:first-child>:nth-child(2)>:nth-child(1){border:1px solid #ccc;border-radius:1em;padding:.33em .5em .25em 1em;box-shadow:0 10px 20px rgba(0,0,0,.19),0 6px 6px rgba(0,0,0,.23);cursor:pointer;font-size:.9em}header>:first-child>:nth-child(2)>:nth-child(1):lang(en):after{content:'English ▼'}header>:first-child>:nth-child(2)>:nth-child(1):lang(ja):after{content:'日本語 ▼'}header>:first-child>:nth-child(2)>:nth-child(1):lang(zh-CN):after{content:'简体中文 ▼'}header>:first-child>:nth-child(2)>:nth-child(1):lang(zh-TW):after{content:'繁體中文 ▼'}header>:first-child>:nth-child(2)>:nth-child(1):lang(ko):after{content:'한국어 ▼'}header>:first-child>:nth-child(2) a{cursor:pointer;margin:.25em 0 0 .75em;font-size:1.125em;display:block}header>:first-child>:nth-child(2)>:nth-child(2){box-shadow:0 10px 20px rgba(0,0,0,.19),0 6px 6px rgba(0,0,0,.23);border-radius:1em;white-space:nowrap;position:absolute;top:2.25em;left:.5em;background-color:#f8f8fc;z-index:1000;padding:.25em 1em .5em 0;opacity:0;visibility:hidden;transition:visibility .2s ease,opacity .2s ease}}header>:first-child>:nth-child(5){font-size:.8em;position:absolute;right:5em;top:9.75em;opacity:.5;padding:.25em .5em .25em 0;text-align:right;max-width:75%;max-width:calc(100% - 30em)}header>:first-child>:nth-child(5):hover{opacity:1}header>:first-child>:nth-child(5) a{margin-left:1em;display:block}footer{margin-top:1.5em;text-align:center;-webkit-touch-callout:none;-webkit-user-select:none;-khtml-user-select:none;-moz-user-select:none;-ms-user-select:none;-o-user-select:none;user-select:none}footer>div>:first-child a{display:inline-block;height:1.5em;padding:0 .25em 0 .25em}footer>div>:first-child a:not(:last-child){border-right:1px solid #ccc}.minimalDisplay #featuredPDBpanel,.minimalDisplay #mine_better_struct,.minimalDisplay #pdbInfoBox{display:none}#loadingImg{position:fixed;top:1em;left:1em;width:10em;height:10em;background-color:#ffffffaa;border-radius:5em;z-index:999;-webkit-backdrop-filter:blur(4px);backdrop-filter:blur(4px);visibility:hidden;opacity:0;transition:visibility .2s ease,opacity .2s ease}#loadingImg.vis{visibility:visible;opacity:1}#pdbInfoBox{position:absolute;top:-.5em;left:.5%;width:15.25%;text-align:center;height:10.5em;background-image:linear-gradient(var(--COLOUR__MAIN_ACCENT),var(--COLOUR__MAIN));border-bottom-right-radius:1em;border-bottom-left-radius:1em;box-shadow:0 10px 20px rgba(0,0,0,.19),0 6px 6px rgba(0,0,0,.23)}#pdbInfoBox>:first-child{padding-top:1em;height:0;position:absolute}#pdbInfoBox>div>:first-child{margin:0;font-size:2.5em;font-weight:700}#pdbInfoBox>div>:nth-child(2){margin:0;font-size:.9em;padding:0 2em 0 2em;display:block}#pdbInfoBox img{width:15%;display:inline-block;margin:.5em}@media only screen and (min-width:75em){#topSearchBox{width:55%;top:4.25em}}#pdbjHeaderImg{cursor:pointer;position:absolute;padding:.2em 0 0 .5em}@media only screen and (min-width:40.001em) and (max-width:75em){#topSearchBox{width:60%;top:4em;max-width:calc(100% - 29em)}}@media only screen and (min-width:40.001em){#pdbjHeaderImg{height:6.4em}}@media only screen and (max-width:40em){#pdbjHeaderImg{height:3.65em}#topSearchBox{top:.5em;width:25%;width:calc(100% - 16em)}#featuredPDBpanel,#mine_better_struct{display:none}}@media only screen and (min-width:40.001em) and (max-width:75em){#featuredPDBpanel,#mine_better_struct{width:23.75%!important}}@media only screen and (max-width:75em){#pdbInfoBox{display:none}}#searchpaginator{border-top-left-radius:2em;border-top-right-radius:2em;z-index:920;position:fixed;bottom:0;background-color:var(--COLOUR__MAIN_ACCENT);border:1px solid #000;border-bottom:0;padding:0 .5em 0 .5em;text-align:center;overflow:hidden}#searchpaginator>:not(:last-child){border-right:1px solid #888}#searchpaginator>*{padding:.66em 1em 1em;display:inline-block;-webkit-touch-callout:none;-webkit-user-select:none;-khtml-user-select:none;-moz-user-select:none;-ms-user-select:none;-o-user-select:none;user-select:none;text-decoration:none}#searchpaginator>p{margin:0}@media only screen and (min-width:75em){#searchpaginator{width:calc(67% - 1em - 1px);left:16.5%}}@media only screen and (max-width:75em){#searchpaginator{left:.5%;color:red}}@media only screen and (min-width:40.001em) and (max-width:75em){#searchpaginator{width:calc(74.5% - 1em - 1px)}}@media only screen and (max-width:40em){#searchpaginator{width:calc(99% - 1em - 1px);left:.5%}}#featuredPDBpanel,#mine_better_struct{position:absolute;top:-.5em;right:.5%;width:15.25%;text-align:center;height:10.5em;z-index:991;background-image:linear-gradient(var(--COLOUR__MAIN_ACCENT),var(--COLOUR__MAIN));border-bottom-right-radius:1em;border-bottom-left-radius:1em;box-shadow:0 10px 20px rgba(0,0,0,.19),0 6px 6px rgba(0,0,0,.23)}#featuredPDBpanel>:first-child,#mine_better_struct>:first-child{height:0;position:absolute;width:100%;opacity:0;transition:opacity .33s ease;padding-top:.5em}#featuredPDBpanel>:first-child>:nth-child(1),#mine_better_struct>:first-child>:nth-child(1){display:inline;color:#00f;padding-top:0;text-align:center;color:var(--COLOUR__TXT);text-decoration:none}#featuredPDBpanel>:first-child>:nth-child(1)>div,#mine_better_struct>:first-child>:nth-child(1)>div{font-family:"Courier New";z-index:900;font-weight:700;position:relative;margin-left:auto;margin-right:auto;display:inline-block;padding:.5em;background-color:rgba(255,255,255,.67);border-bottom-left-radius:1em;border-bottom-right-radius:1em}#featuredPDBpanel>:first-child>:nth-child(1):hover>div,#mine_better_struct>:first-child>:nth-child(1):hover>div{-webkit-backdrop-filter:blur(4px);backdrop-filter:blur(4px)}#featuredPDBpanel>:first-child>:nth-child(1)>img,#mine_better_struct>:first-child>:nth-child(1)>img{margin-left:auto;margin-right:auto;margin-top:-2.125em;display:block}#featuredPDBpanel>:nth-child(2),#mine_better_struct>:nth-child(2){position:absolute;right:.5em;width:25%;bottom:1.75em;color:#00f}.linkLike{color:#00f;cursor:pointer}.linkLike:hover{color:red}.nwButton{text-align:center;border:1px solid var(--COLOUR__MAIN_BORDER);display:inline-block;border-radius:1em;font-size:1em;font-weight:700;padding:.5em 1em .5em 1em;background-color:var(--COLOUR__MAIN_MILD_SELECT);-webkit-touch-callout:none;-webkit-user-select:none;-khtml-user-select:none;-moz-user-select:none;-ms-user-select:none;-o-user-select:none;user-select:none;box-shadow:0 3px 6px rgba(0,0,0,.16),0 3px 6px rgba(0,0,0,.23);cursor:pointer;margin-bottom:1em;font-family:inherit;font-size:1em;text-decoration:none;color:var(--COLOUR__TXT);transition:all .3s cubic-bezier(.25,.8,.25,1)}.nwButton:disabled{filter:grayscale(100%);color:grey}.nwButton:focus{outline:0}.nwButton:hover:enabled{box-shadow:0 10px 20px rgba(0,0,0,.19),0 6px 6px rgba(0,0,0,.23)}a.nwButton:hover{box-shadow:0 10px 20px rgba(0,0,0,.19),0 6px 6px rgba(0,0,0,.23);color:#000!important}.grayscale{-webkit-filter:grayscale(100%);-moz-filter:grayscale(100%);-ms-filter:grayscale(100%);-o-filter:grayscale(100%);filter:grayscale(100%);filter:url("data:image/svg+xml;utf8,<svg xmlns=\'http://www.w3.org/2000/svg\'><filter id=\'grayscale\'><feColorMatrix type=\'matrix\' values=\'0.3333 0.3333 0.3333 0 0 0.3333 0.3333 0.3333 0 0 0.3333 0.3333 0.3333 0 0 0 0 0 1 0\'/></filter></svg>#grayscale");filter:gray}.unselectableText{-webkit-touch-callout:none;-webkit-user-select:none;-khtml-user-select:none;-moz-user-select:none;-ms-user-select:none;-o-user-select:none;user-select:none}.opacityTransition{opacity:.4s cubic-bezier(.25,.8,.25,1)}.opacityTransition2{transition:visibility .4s cubic-bezier(.25,.8,.25,1),opacity .4s cubic-bezier(.25,.8,.25,1)}.menuTransition{transition:visibility .4s cubic-bezier(.25,.8,.25,1),opacity .4s cubic-bezier(.25,.8,.25,1),height .4s cubic-bezier(.25,.8,.25,1)}.allTransition{transition:all .4s cubic-bezier(.25,.8,.25,1)}.OGhover{opacity:.25}.OGhover:hover{opacity:1}.BLOG_BOX{overflow-wrap:anywhere;padding:0 1.25em 0 3em}.BLOG_BOX pre{white-space:pre-wrap}.BLOG_BOX a{display:inline!important}.sNP{border-radius:1em;background-color:var(--COLOUR__MAIN_ACCENT);margin-bottom:1em;border:1px solid var(--COLOUR__MAIN_BORDER);box-shadow:0 10px 20px rgba(0,0,0,.19),0 6px 6px rgba(0,0,0,.23)}.sNP>:first-child{position:relative;border-top-left-radius:16px;border-top-right-radius:16px;font-size:1em;font-weight:700;padding:.5em 1em .5em 1em;min-height:1em;background-image:linear-gradient(rgb(var(--COLOUR__MAIN_MILD)),var(--COLOUR__MAIN_ACCENT));-webkit-touch-callout:none;-webkit-user-select:none;-khtml-user-select:none;-moz-user-select:none;-ms-user-select:none;-o-user-select:none;user-select:none;display:block;overflow-wrap:anywhere}.sNP>:nth-child(2){padding:.5em 1em 1em 1em;visibility:visible;opacity:1;height:100%;background-color:var(--COLOUR__MAIN_ACCENT);border-bottom-left-radius:1em;border-bottom-right-radius:1em}.sNP_collapse>:nth-child(2){height:0;visibility:hidden;opacity:0;margin-bottom:-1em}.sNP>h1:first-child,.sNP>h3:first-child{margin:0;font-size:1.5em;border-top-left-radius:.8em;border-top-right-radius:.8em;padding:.35em .7em .35em .7em}.sNP.ddM{box-shadow:0 3px 6px rgba(0,0,0,.16),0 3px 6px rgba(0,0,0,.23)}.sNP.ddM.sNPex>:first-child{padding:.5em 1em 1em 4em;border-radius:16px}.sNP.ddM.sNPex>:nth-child(2){z-index:999;position:absolute;background-color:var(--COLOUR__BG);color:var(--COLOUR__TXT);margin-left:.75em;border-bottom-right-radius:1em;border-bottom-left-radius:1em;border-top:none!important;overflow:hidden;height:initial;width:calc(100% - 16em);border:1px solid var(--COLOUR__MAIN_BORDER);box-shadow:0 10px 20px rgba(0,0,0,.19),0 6px 6px rgba(0,0,0,.23)}.sNP.ddM label{cursor:pointer;-webkit-touch-callout:none;-webkit-user-select:none;-khtml-user-select:none;-moz-user-select:none;-ms-user-select:none;-o-user-select:none;user-select:none;display:block;padding:.25em;margin:0;font-size:.9em}.sNP.ddM a{cursor:pointer;-webkit-touch-callout:none;-webkit-user-select:none;-khtml-user-select:none;-moz-user-select:none;-ms-user-select:none;-o-user-select:none;user-select:none;display:block;padding:.25em;margin:0;font-size:.9em}.sNP.ddM label.sel{background-image:linear-gradient(to right,var(--COLOUR__MAIN_MILD_SELECT),var(--COLOUR__MAIN_ACCENT));font-weight:700;font-style:italic}.sNP.ddM label:hover{color:var(--COLOUR__MAIN_OPPOSITE)}.sNP.ddM input{display:none;color:var(--COLOUR__TXT)}.sNPex>:first-child{padding-left:3em}.sNPex>:first-child:before{position:absolute;cursor:pointer;margin-top:.33em;width:0;height:0;border-left:.75em solid transparent;border-right:.75em solid transparent;border-top:.75em solid #fff;border-bottom:0 solid transparent;transition:all .4s ease;content:'';margin-left:-2em}.sNPex>:first-child:hover:before{border-top:.75em solid var(--COLOUR__MAIN_OPPOSITE)}.sNP_collapse>:first-child:before{transform:rotate(-90deg)}.visible{opacity:1!important;visibility:visible!important}.hidden{opacity:0;visibility:hidden}.sPlane{border-radius:1em;padding:1em;background-color:var(--COLOUR__BG);margin-bottom:2em;border:1px solid var(--COLOUR__MAIN_BORDER);box-shadow:0 10px 20px rgba(0,0,0,.19),0 6px 6px rgba(0,0,0,.23)}@media only screen and (max-width:40em){.sPlane{padding:.5em}}.fancySearch{position:relative;padding:1px 2.5em 1px 1.5em;background-color:var(--COLOUR__BG);border-radius:1em;border:1px solid #888;height:2.67em;max-height:2.67em;transition:width .4s ease,min-width .4s ease,height .4s ease,min-height .4s ease;box-shadow:0 3px 6px rgba(0,0,0,.16),0 3px 6px rgba(0,0,0,.23)}.fancySearch>:first-child{margin-top:-1px;height:2.8em;width:2.5em;padding:0 .25em 0 .25em;display:inline;position:absolute;cursor:pointer;right:0;background-color:#888;border-top-right-radius:.9em;border-bottom-right-radius:.9em;transition:all .3s cubic-bezier(.25,.8,.25,1)}.fancySearch svg>circle{stroke:white;stroke-width:7;fill:transparent}.fancySearch svg>ellipse{fill:white}.fancySearch>:first-child:hover{background-color:var(--COLOUR__MAIN_BORDER)}.fancySearch>input{vertical-align:middle;border:1px solid #888;background-color:var(--COLOUR__BG);font:1em courier new;padding:.15em .5em .15em .5em;margin:.33em 0 .125em 0;overflow:auto;height:2em;border-radius:.5em;width:95%;outline:0;color:var(--COLOUR__TXT);width:calc(100% - 2em);border:none}@media only screen and (max-width:40em){#topSearchBox.fancySearch{padding-left:.5em}}@media only screen and (max-width:27em){#topSearchBox.fancySearch{top:4.25em!important;width:calc(100% - 5em)!important}}.fancySearch>:nth-child(3){transition:top .4s ease,bottom .4s ease,left .4s ease,right .4s ease,min-width .4s ease,width .4s ease,height .4s ease,opacity .4s ease,visibility .4s ease;top:2.75em;position:absolute;width:85%;width:calc(100% - 6em);height:0;overflow:hidden;z-index:100;background-color:var(--COLOUR__BG);right:3em;margin-right:-1px;border-bottom-left-radius:1em;border-bottom-right-radius:1em;padding:.5em;border:1px solid #888;border-top-color:transparent;transition:width .4s ease,height .4s ease,opacity .4s ease,visibility .4s ease;opacity:0;visibility:hidden;box-shadow:0 10px 20px rgba(0,0,0,.19),0 6px 6px rgba(0,0,0,.23)!important;-webkit-touch-callout:none;-webkit-user-select:none;-khtml-user-select:none;-moz-user-select:none;-ms-user-select:none;-o-user-select:none;user-select:none}.textBox{vertical-align:middle;border:1px solid #888;background-color:var(--COLOUR__BG);font:1em courier new;padding:.15em .5em .15em .5em;margin:.125em 0 .125em 0;overflow:auto;height:2em;border-radius:.5em;width:95%;width:calc(100% - 1.125em);outline:0;color:var(--COLOUR__TXT)}.fancySearch .closeButton{right:.25em;top:0}.closeButton{position:absolute;margin-top:.25em;right:1.1em;cursor:pointer;border-radius:1em;width:1em;height:1em;border:1px solid transparent;text-align:center;padding:.025em .275em .475em .275em;font-weight:700;text-decoration:none;color:var(--COLOUR__TXT);z-index:900;transition:top .4s ease,bottom .4s ease,left .4s ease,right .4s ease,min-width .4s ease,width .4s ease,height .4s ease,opacity .4s ease,visibility .4s ease}.closeButton:hover{border-color:var(--COLOUR__MAIN_OPPOSITE)}@media only screen and (min-width:40.001em){.tabbedPlane{left:2.5em;width:90%;width:calc(100% - 5em)}}@media only screen and (max-width:40em){.tabbedPlane{left:1em;width:95%;width:calc(100% - 2em)}}.tabbedPlane{font-weight:700;display:inline-block;position:relative;top:1px;z-index:0;margin-top:-.5em}.tabbedPlane a,.tabbedPlane span{color:var(--COLOUR__TXT);text-decoration:none;box-shadow:0 10px 20px rgba(0,0,0,.19),0 6px 6px rgba(0,0,0,.23);-webkit-touch-callout:none;-webkit-user-select:none;-khtml-user-select:none;-moz-user-select:none;-ms-user-select:none;-o-user-select:none;user-select:none;transition:all .4s ease,padding 0s!important;font-size:1em;height:1.25em;padding:.5em .5em .75em .5em;display:inline-block;margin:.5em .25em 0 0;cursor:pointer;opacity:.5;position:relative;top:.25em;border:1px solid rgb(var(--COLOUR__MAIN_MILD));background-color:rgba(var(--COLOUR__MAIN_MILD),.33);border-radius:1em 1em 0 0}.tabbedPlane .tab_sel{padding-top:.75em!important;top:0!important}.tabbedPlane.bottom{z-index:10}.tabbedPlane a:hover{background-color:rgb(var(--COLOUR__MAIN_MILD));opacity:1}.tabbedPlane .tab_sel{background-image:linear-gradient(#fff,rgba(255,255,255,0));background-color:rgb(var(--COLOUR__MAIN_MILD));box-shadow:0 10px 20px rgba(0,0,0,.19),0 6px 6px rgba(0,0,0,.23);opacity:1}.tabbedPlane.b.tab_sel{background-image:linear-gradient(rgba(255,255,255,0),#fff)!important}.tabbedPlane .tab_sel{background-color:rgb(var(--COLOUR__MAIN_MILD))}.tabbedPlane+div{border-radius:1em;padding:1em;background-color:var(--COLOUR__BG);margin-bottom:2em;border:1px solid var(--COLOUR__MAIN_BORDER);box-shadow:0 10px 20px rgba(0,0,0,.19),0 6px 6px rgba(0,0,0,.23);z-index:1;position:relative}#infoBox{z-index:999;position:fixed;width:25em;bottom:.5em;right:1em;visibility:hidden;background-color:var(--COLOUR__MAIN_ACCENT);color:var(--COLOUR__TXT)}#infoBox>:nth-child(2){visibility:inherit;overflow-wrap:break-word}#infoBox>:first-child{font-size:1.5em}.optCat_p{cursor:pointer;width:1.25em;display:inline-block;font-family:courier;text-align:center}.optCat_n{cursor:pointer}.sbp_tags label{display:inline-block;margin-right:.5em}.sbp_tags input{font-size:.8em;color:var(--COLOUR__TXT)}#topSearchBox{position:absolute;right:1em;z-index:999}.pEC_tableMenu{position:absolute;border:1px solid #000;border-radius:.5em;padding:.25em;background-color:var(--COLOUR__BG);z-index:999;box-shadow:0 10px 20px rgba(0,0,0,.19),0 6px 6px rgba(0,0,0,.23)}.pEC_tableMenu>div{padding:.25em}.pEC_tableMenu>div.title{display:inline-block;min-height:1em}.pEC_tableMenu>div:not(.title):hover{cursor:pointer;background-color:red}.pEC_tableMenu label{padding:.25em;display:block;cursor:pointer}.pEC_tableMenu label:hover{background-color:#eee}.pEC_iconButton{border:1px solid #000;border-radius:.8em;width:1.6em;display:inline-block;text-align:center;font-weight:700;line-height:1.6em;margin-left:.33em;font-size:.75em;vertical-align:top;padding:0!important;position:absolute;right:0;top:-.33em}.pEC_iconButton:hover{color:red;border-color:red;cursor:pointer}.entryMenu{border-bottom:1px dotted;cursor:pointer}.entryMenu:after{content:'\25be';border-radius:1em;padding-left:.175em;padding-right:.175em}.entryMenu:hover:after{background-color:#ddd}#pdb_img_popup{border-radius:.5em;width:15%;border:1px solid var(--COLOUR__MAIN);position:absolute;z-index:999;box-shadow:0 10px 20px rgba(0,0,0,.19),0 6px 6px rgba(0,0,0,.23);transition:visibility .2s ease,opacity .2s ease;visibility:hidden;opacity:0;padding:.25em}#pdb_img_popup>img{width:100%}#pdb_img_popup>div{position:absolute}.molmil_container{width:100%;position:relative}.aspect_1to1{padding-top:100%}.aspect_2to1{padding-top:50%}.molmil_container>iframe{position:absolute;top:0;height:100%;width:100%;border:none}.codeQuoteBox{border:1px solid #000;margin-left:1em;margin-right:1em;font-family:courier;background-color:var(--COLOUR__MAIN_MILD_SELECT);border:solid thin #99a;padding:.5em;overflow:auto}.dragPlane{position:absolute;z-index:999}.dragPlane .closeButton{margin-top:-1.33em}.dragPlane>:first-child{cursor:move}.newweb-auto-date:not(.not){cursor:default;text-decoration-style:dashed;text-decoration-line:underline}</style><style data-module="mine">#explorePDB_3d>div:nth-child(2){text-align:center}#PDBExplorerPlane h1,#PDBExplorerPlane h2{font-size:2em;margin:.25em 0 .75em .75em;padding:.5em;font-weight:700;background-image:linear-gradient(to right,rgb(var(--COLOUR__MAIN_MILD)),var(--COLOUR__MAIN_ACCENT));position:relative;display:block;border-radius:.5em}#PDBExplorerPlane h2{font-size:1.5em!important;padding:1.5em .5em 1.5em .5em!important;margin:.33em 0 1em 1em}#PDBExplorerPlane div{margin:.5em 0 0 2em}#PDBExplorerPlane span{margin:.5em 0 0 2em;display:block}#explorePDBTab_summary_sum table{table-layout:fixed;width:100%}#explorePDBTab_expdet table,#explorePDBTab_funcdet_go table,#explorePDBTab_history_plane table,#explorePDBTab_resources_plane table,#explorePDBTab_strucdet table,#explorePDBTab_summary table,#explorePDB_dl_menu table,.mine_fd_t1,.mine_fd_t2{border-collapse:collapse}#explorePDBTab_expdet table>tbody>tr:nth-child(odd),#explorePDBTab_funcdet_go table>tbody>tr:nth-child(odd),#explorePDBTab_history_plane tbody>tr:nth-child(odd),#explorePDBTab_resources_plane tbody>tr:nth-child(odd),#explorePDBTab_strucdet table>tbody>tr:nth-child(odd),#explorePDBTab_summary table>tbody>tr:nth-child(odd),#explorePDB_dl_menu table>tbody>tr:nth-child(odd),.mine_fd_t1>tbody>tr:nth-child(odd),.mine_fd_t2>tbody>tr:nth-child(odd){background-color:var(--COLOUR__SWITCH_1)}#explorePDBTab_expdet table>tbody>tr:nth-child(2n),#explorePDBTab_funcdet_go table>tbody>tr:nth-child(2n),#explorePDBTab_history_plane tbody>tr:nth-child(2n),#explorePDBTab_resources_plane tbody>tr:nth-child(2n),#explorePDBTab_strucdet table>tbody>tr:nth-child(2n),#explorePDBTab_summary table>tbody>tr:nth-child(2n),#explorePDB_dl_menu table>tbody>tr:nth-child(2n),.mine_fd_t1>tbody>tr:nth-child(2n),.mine_fd_t2>tbody>tr:nth-child(2n){background-color:var(--COLOUR__SWITCH_3)}#explorePDB_dl_menu table{width:100%}#explorePDB_dl_menu img{height:1.25em;width:auto;cursor:pointer;position:absolute;z-index:100;margin-top:.25em;transition:margin .2s ease,height .2s ease}#explorePDB_dl_menu td:first-child img:hover{height:2em;margin-top:-.167em;margin-left:-.33em;z-index:101}#explorePDB_dl_menu td:nth-child(2) img:hover{height:2em;margin-top:-.167em;margin-left:.9em;z-index:101}#explorePDB_dl_menu tr{display:block;padding:.25em 0 .25em 0}#explorePDB_dl_menu td{display:inline;width:0}#explorePDB_dl_menu td:first-child img{margin-top:.1em}#explorePDB_dl_menu td:nth-child(2) img{margin-left:1.25em;margin-top:.1em}#explorePDB_dl_menu td:nth-child(3){font-size:.9em;margin-left:3em}#explorePDB_dl_menu>div:nth-child(2)>a{color:var(--COLOUR__TXT);font-size:.9em;margin-left:3.44em}#explorePDB_dbinfo_menu div:nth-child(2){padding-bottom:0}#explorePDB_dbinfo_menu a{display:block;text-decoration:none;color:var(--COLOUR__TXT);word-break:break-all}#explorePDB_dbinfo_menu div>a{padding:0 0 .5em 1em}#explorePDB_dbinfo_menu div>a.linkchild{padding:0 0 .5em 0!important;font-style:italic}#explorePDB_dbinfo_menu div>div{font-style:italic;padding:0 0 .5em 1em}#explorePDB_dbinfo_menu.bird{font-style:italic;padding:0 0 .5em 1em}.eI_bird{font-weight:700;padding-left:.1em}#explorePDBTab_summary_sum tr>td:first-child{width:20%;text-align:left;font-weight:700}#explorePDBTab_summary_sum tr>td:nth-child(2){vertical-align:top;padding:.5em;overflow:hidden;width:80%;margin-left:1em;display:inline-block}#explorePDBTab_summary_validation>div:nth-child(2)>img{height:30em;display:block;margin-left:auto;margin-right:auto}#explorePDBTab_summary_validation div>a>img{width:1.25em;margin-bottom:-.33em;margin-left:.5em}#explorePDBTab_strucdet_entity table{width:100%;font-size:.8em;table-layout:fixed}#explorePDBTab_strucdet_entity td{overflow:hidden;padding:.5em}#explorePDBTab_strucdet_entity tr:first-child{font-weight:700;border-bottom:2px solid var(--COLOUR__MAIN);vertical-align:bottom;padding:.5em}#explorePDBTab_strucdet_entity td:nth-child(n+5):nth-child(-n+6){text-align:right}#explorePDBTab_strucdet_entity td:nth-child(7){text-align:center}#explorePDBTab_strucdet_entity td:first-child{width:4%;font-weight:700}#explorePDBTab_strucdet_entity td:nth-child(2){width:4%}#explorePDBTab_strucdet_entity td:nth-child(3){width:25%}#explorePDBTab_strucdet_entity td:nth-child(4){width:8%}#explorePDBTab_strucdet_entity td:nth-child(5){width:5%}#explorePDBTab_strucdet_entity td:nth-child(6){width:8%}#explorePDBTab_strucdet_entity td:nth-child(7){width:8%}#explorePDBTab_strucdet_entity td:nth-child(8){width:14.5%}#explorePDBTab_strucdet_entity td:nth-child(9){width:11%}#explorePDBTab_strucdet_entity td:nth-child(10){width:9%}.seqViewer{font-family:courier;word-wrap:break-word}#sequenceViewer{width:calc(100% - 10em);margin-left:2em;display:inline-block;vertical-align:middle}#sequenceViewer+div>:first-child{height:1em}.sv_blueSphere,.sv_cyanSphere,.sv_greenSphere,.sv_magentaSphere,.sv_orangeSphere,.sv_redSphere,.sv_yellowSphere{width:1em;height:1em;display:inline-block;border:1px solid #000;border-radius:.5em;position:relative;top:.125em;margin-right:.5em}.sv_blueSphere{background-color:#00f}.sv_redSphere{background-color:red}.sv_orangeSphere{background-color:orange}.sv_greenSphere{background-color:green}.sv_cyanSphere{background-color:#0ff}.sv_yellowSphere{background-color:#ff0}.sv_magentaSphere{background-color:#ff00ff}.sv_blueSquare,.sv_orangeSquare{width:1em;height:1em;display:inline-block;border:1px solid #000;position:relative;top:.125em;margin-right:.5em}.sv_blueSquare{background-color:#00f}.sv_orangeSquare{background-color:pink}#explorePDBTab_strucdet_asym td:first-child[rowspan]{font-weight:700}#explorePDBTab_strucdet_asym>:nth-child(2)>:nth-child(2){margin-top:2em;color:#00f;font-size:.8em}#explorePDBTab_strucdet_asym table span{color:#00f;vertical-align:super;font-size:.8em}#explorePDBTab_strucdet_asym table td{padding:.33em}#explorePDBTab_strucdet_asym table>tbody>tr:nth-child(2n){border-bottom:1px solid var(--COLOUR__MAIN)}@media only screen and (max-width:75em){#explorePDBTab_strucdet_entity table,#explorePDBTab_strucdet_entity tbody,#explorePDBTab_strucdet_entity td,#explorePDBTab_strucdet_entity thead,#explorePDBTab_strucdet_entity tr{display:block}#explorePDBTab_strucdet_entity table{font-size:1em!important}#explorePDBTab_strucdet_entity tr:first-child{position:absolute;top:-9999px;left:-9999px}#explorePDBTab_strucdet_entity tr{border:1px solid #ccc}#explorePDBTab_strucdet_entity td{border:none;border-bottom:1px solid #eee;position:relative;padding:.5em .5em .5em 13em!important;width:initial!important;text-align:initial!important;min-height:1.25em}#explorePDBTab_strucdet_entity td:before{position:absolute;top:.5em;left:.5em;width:12em;padding-right:1em;content:attr(col-header);font-weight:700;text-align:left}}#explorePDBTab_expdet_xray_data table,#explorePDBTab_expdet_xray_refn table{width:100%;max-width:30em}#explorePDBTab_expdet_nmr_spec :nth-child(2)>div,#explorePDBTab_expdet_other_ref :nth-child(2)>div,#explorePDBTab_expdet_xray_refn :nth-child(2)>div{margin:0 0 1em .5em}#explorePDBTab_expdet_other_ref td:first-child,#explorePDBTab_expdet_xray_refn td:first-child{font-weight:700;width:55%}#explorePDBTab_expdet_xray_data td:first-child p,#explorePDBTab_expdet_xray_refn td:first-child p{font-size:.8em;padding:.5em;text-align:right;font-weight:initial}#explorePDBTab_expdet_other_crysc td:nth-child(n+2) p,#explorePDBTab_expdet_xray_crysc td:nth-child(n+2) p,#explorePDBTab_expdet_xray_crysr td:nth-child(n+2) p,#explorePDBTab_expdet_xray_data td:nth-child(n+2) p,#explorePDBTab_expdet_xray_refn td:nth-child(n+2) p,.mine_fd_t2 p{display:inline;color:#40e0d0;vertical-align:super;font-size:.8em;cursor:help}#explorePDBTab_expdet_other_ref td:nth-child(2),#explorePDBTab_expdet_other_ref td:nth-child(3),#explorePDBTab_expdet_other_ref td:nth-child(4),#explorePDBTab_expdet_xray_refn td:nth-child(2),#explorePDBTab_expdet_xray_refn td:nth-child(3),#explorePDBTab_expdet_xray_refn td:nth-child(4){width:15%;vertical-align:top;padding:7px;text-align:center}#explorePDBTab_expdet_xray_data td:first-child{font-weight:700;width:55%}#explorePDBTab_expdet_xray_data td:nth-child(2){width:45%;vertical-align:top;padding:7px;text-align:center}#explorePDBTab_expdet_other_crysc table,#explorePDBTab_expdet_xray_crysc table,#explorePDBTab_expdet_xray_crysr table,#explorePDBTab_expdet_xray_crysrg table{width:100%}#explorePDBTab_expdet_xray_crysc tr:first-child{font-weight:700}#explorePDBTab_expdet_xray_crysc td:first-child{width:10%;vertical-align:top}#explorePDBTab_expdet_xray_crysc td:nth-child(2){width:35%;vertical-align:top}#explorePDBTab_expdet_xray_crysc td:nth-child(3){width:10%;vertical-align:top}#explorePDBTab_expdet_xray_crysc td:nth-child(4){width:10%;vertical-align:top}#explorePDBTab_expdet_xray_crysc td:nth-child(5){width:35%;vertical-align:top}#explorePDBTab_expdet_other_crysc tr:first-child,#explorePDBTab_expdet_xray_crysrg tr:first-child{font-weight:700}#explorePDBTab_expdet_other_crysc td:first-child,#explorePDBTab_expdet_xray_crysrg td:first-child{width:10%;vertical-align:top}#explorePDBTab_expdet_other_crysc td:nth-child(2),#explorePDBTab_expdet_xray_crysrg td:nth-child(2){width:10%;vertical-align:top}#explorePDBTab_expdet_other_crysc td:nth-child(3),#explorePDBTab_expdet_xray_crysrg td:nth-child(3){width:10%;vertical-align:top}#explorePDBTab_expdet_other_crysc td:nth-child(4),#explorePDBTab_expdet_xray_crysrg td:nth-child(4){width:40%;vertical-align:top}#explorePDBTab_expdet_other_crysc td:nth-child(5),#explorePDBTab_expdet_xray_crysrg td:nth-child(5){width:15%;vertical-align:top}#explorePDBTab_expdet_other_crysc td:nth-child(6),#explorePDBTab_expdet_xray_crysrg td:nth-child(6){width:15%;vertical-align:top}#explorePDBTab_expdet_xray_crysr tr:first-child{font-weight:700}#explorePDBTab_expdet_xray_crysr td:first-child{width:10%;vertical-align:top}#explorePDBTab_expdet_xray_crysr td:nth-child(2){width:10%;vertical-align:top}#explorePDBTab_expdet_xray_crysr td:nth-child(3){width:20%;vertical-align:top}#explorePDBTab_expdet_xray_crysr td:nth-child(4){width:20%;vertical-align:top}#explorePDBTab_expdet_xray_crysr td:nth-child(5){width:20%;vertical-align:top}#explorePDBTab_expdet_xray_crysr td:nth-child(6){width:20%;vertical-align:top}#explorePDBTab_expdet_xray_exp td:nth-child(2) p,#explorePDBTab_expdet_xray_qual td:nth-child(2) p,#explorePDBTab_expdet_xray_qual td:nth-child(3) p,#explorePDBTab_expdet_xray_qual td:nth-child(4) p,#explorePDBTab_expdet_xray_refi td:nth-child(2) p{display:inline;color:#40e0d0;vertical-align:super;font-size:.8em;cursor:help}#explorePDBTab_expdet_xray_qual td:nth-child(2),#explorePDBTab_expdet_xray_qual td:nth-child(3),#explorePDBTab_expdet_xray_qual td:nth-child(4){text-align:right}#explorePDBTab_expdet_xray_exp table,#explorePDBTab_expdet_xray_qual table,#explorePDBTab_expdet_xray_refi table{width:100%;max-width:50em}#explorePDBTab_expdet_xray_qual tr:first-child{font-weight:700}#explorePDBTab_expdet_xray_exp td,#explorePDBTab_expdet_xray_qual td,#explorePDBTab_expdet_xray_refi td{vertical-align:middle}#explorePDBTab_expdet_xray_exp td:first-child,#explorePDBTab_expdet_xray_qual td:first-child,#explorePDBTab_expdet_xray_refi td:first-child{font-weight:700;padding:7px}#explorePDBTab_expdet_xray_exp td:nth-child(2),#explorePDBTab_expdet_xray_refi td:nth-child(2){width:50%}#explorePDBTab_expdet_xray_qual td:nth-child(2),#explorePDBTab_expdet_xray_qual td:nth-child(3),#explorePDBTab_expdet_xray_qual td:nth-child(4){width:20%}#explorePDBTab_expdet_xray_qual table:nth-child(2){margin-top:2em}#explorePDBTab_expdet_xray_qual table:nth-child(2) td:first-child{width:30%}#explorePDBTab_expdet_xray_qual table:nth-child(2) tr:nth-child(2) td:first-child,#explorePDBTab_expdet_xray_qual table:nth-child(2) tr:nth-child(3) td:first-child,#explorePDBTab_expdet_xray_qual table:nth-child(2) tr:nth-child(4) td:first-child{font-weight:400}#explorePDBTab_expdet_xray_qual table:nth-child(2) td:nth-child(2){width:70%}#explorePDBTab_expdet_em_data td:first-child,#explorePDBTab_expdet_em_recon td:first-child,#explorePDBTab_expdet_em_spec td:first-child{font-weight:700;padding-right:2em}#explorePDBTab_expdet_nmr_exp table,#explorePDBTab_expdet_nmr_smpl table,#explorePDBTab_expdet_nmr_spec table{width:100%}#explorePDBTab_expdet_nmr_conf table td:first-child,#explorePDBTab_expdet_nmr_exp tr:first-child,#explorePDBTab_expdet_nmr_smpl tr:first-child,#explorePDBTab_expdet_nmr_spec tr:first-child{font-weight:700}#explorePDBTab_expdet_nmr_conf table{width:100%;max-width:30em}#explorePDBTab_funcdet_go tr:first-child{font-weight:700}#explorePDBTab_funcdet_go table{width:100%}.mine_fd_t1 td:first-child{font-weight:700;width:8em}.mine_fd_t2{margin-left:9em;width:calc(100% - 9em)}.mine_fd_t1{width:100%}.mine_fd_t2 td:first-child{width:8em}.mine_fd_t2 tr:first-child{font-weight:700;border-top:2px solid var(--COLOUR__MAIN)}@media only screen and (min-width:40.001em) and (max-width:52em){#explorePDBTab_resources_plane table{overflow-wrap:anywhere;display:block}#explorePDBTab_resources_plane tbody{display:block;width:69vw}}@media only screen and (max-width:40em){#explorePDBTab_resources_plane table{overflow-wrap:anywhere;display:block}#explorePDBTab_resources_plane tbody{display:block;width:92vw}}#explorePDBTab_resources_plane table{margin:0 auto}#explorePDBTab_resources_plane tbody{max-width:60em;display:block}#explorePDBTab_resources_plane td{padding:.5em 1em}#explorePDBTab_resources_plane tr:first-child{font-weight:700}#explorePDBTab_resources_plane .last,#explorePDBTab_resources_plane td[rowspan]{border-bottom:1px solid var(--COLOUR__MAIN)}#explorePDBTab_resources_plane tr:first-child,#explorePDBTab_resources_plane tr:last-child{border-bottom:2px solid var(--COLOUR__MAIN)}#explorePDBTab_resources_plane p{font-size:smaller;margin-top:0;max-width:20em}#explorePDBTab_history #explorePDBTab_resources_plane{display:none}#explorePDBTab_history_plane table{width:100%}#explorePDBTab_history_plane tr:first-child{font-weight:700}#explorePDBTab_history_plane>div:nth-child(2)>div{margin-bottom:1em}.mine_pdb_dl_panel{margin-top:.25em}.mine_pdb_dl_panel img{height:1.25em;width:auto;cursor:pointer;position:absolute;z-index:100;margin-top:.25em}.mine_pdb_dl_panel td{display:inline;width:0;padding:.25em}.mine_pdb_dl_panel td>div{margin-left:2.67em;font-size:.9em;display:inline!important}@media only screen and (max-width:75em){.mine_resource_table{width:100%!important}}.mine_resource_table span{display:inline-block;max-width:50%}.mine_resource_table .sNP{white-space:nowrap;width:10em;float:right;display:inline-block}.mine_resource_table{min-width:40em;width:60%;margin:0 auto;max-width:100%;overflow:hidden}@media only screen and (max-width:45em){.mine_resource_table{min-width:initial!important}.mine_resource_table .sNP{float:none;display:block}}@media only screen and (max-width:35em){.mine_resource_table td{width:initial!important;padding-right:initial!important}}.mineSQLHelper_category{font-weight:700}.mineSQLHelper_filterOption{margin-left:1em;cursor:pointer}.mineSQLHelper_filterOption.mineSQLHelper_category{margin-left:0!important;font-weight:400!important}.mineSQLHelper_filterOption:hover{background-color:#ff0}@media only screen and (max-width:75em){#chemie_expl_sum_desc table,#chemie_expl_sum_desc tbody,#chemie_expl_sum_desc td,#chemie_expl_sum_desc thead,#chemie_expl_sum_desc tr{display:block}#chemie_expl_sum_desc table{font-size:1em!important}#chemie_expl_sum_desc tr:first-child{position:absolute;top:-9999px;left:-9999px}#chemie_expl_sum_desc tr{border:1px solid #ccc}#chemie_expl_sum_desc td{border:none;border-bottom:1px solid #eee;position:relative;padding:.5em .5em .5em 13em!important;width:initial!important;text-align:initial!important;min-height:1.25em;word-break:break-all}#chemie_expl_sum_desc td:before{position:absolute;top:.5em;left:.5em;width:12em;padding-right:1em;content:attr(col-header);font-weight:700;text-align:left}}#exploreCCTab_summary_sum table:first-child tr:nth-child(1) td:nth-child(2){overflow-wrap:anywhere}#contentMenu_exploreCC table td:first-child,#exploreCCTab_summary_sum table:first-child td:first-child{font-weight:700;min-width:6em}#contentMenu_exploreCC table,#exploreCCTab_summary_sum table{border-collapse:collapse;width:100%}#exploreCCTab_summary_sum table:nth-child(4) td:nth-child(3),#exploreCCTab_summary_sum table:nth-child(7) td:nth-child(4){overflow-wrap:anywhere}#contentMenu_exploreCC table>tbody>tr:nth-child(odd),#exploreCCTab_summary_sum table>tbody>tr:nth-child(odd){background-color:var(--COLOUR__SWITCH_1)}#contentMenu_exploreCC table>tbody>tr:nth-child(2n),#exploreCCTab_summary_sum table>tbody>tr:nth-child(2n){background-color:var(--COLOUR__SWITCH_3)}#contentMenu_exploreCC .ddM>:nth-child(2){color:red}#contentMenu_exploreCC .ddM a{display:block}#exploreCCTab_summary_sum table:nth-child(n+2) tr:first-child{font-weight:700}#exploreCCTab_geometry table{border-collapse:collapse}#exploreCCTab_geometry table tr:first-child{font-weight:700}#exploreCCTab_geometry table>tbody>tr:nth-child(odd){background-color:var(--COLOUR__SWITCH_1)}#exploreCCTab_geometry table>tbody>tr:nth-child(2n){background-color:var(--COLOUR__SWITCH_3)}#exploreCCTab_geometry_bonds table td:nth-child(4),#exploreCCTab_geometry_bonds table td:nth-child(5){text-align:right}#exploreCCTab_geometry_angles table td:nth-child(4),#exploreCCTab_geometry_angles table td:nth-child(5){text-align:right}#exploreCCTab_geometry_dihedrals table td:nth-child(5),#exploreCCTab_geometry_dihedrals table td:nth-child(6){text-align:right}#explorePDBTab_resources_plane .nwButton{width:10em;float:right}#explorePDB_seqnavi_chains table{border-collapse:collapse}#explorePDB_seqnavi_chains table tr:first-child{font-weight:700}#explorePDB_seqnavi_chains table tr>td:first-child{width:10%;text-align:center}#explorePDB_seqnavi_chains table tr>td:nth-child(2){width:80%}#explorePDB_seqnavi_chains table tr>td:nth-child(3){width:10%;text-align:center}#explorePDB_seqnavi_chains table tr:nth-child(odd){background-color:var(--COLOUR__SWITCH_1)}#explorePDB_seqnavi_chains table tr:nth-child(2n){background-color:var(--COLOUR__SWITCH_3)}#explorePDB_seqnavi_chains table .nwButton{margin-right:1em}#obs_pdb_summary table{border-collapse:collapse;width:100%}#obs_pdb_summary table tr>td:first-child{font-weight:700}#obs_pdb_summary table>tbody>tr:nth-child(odd){background-color:var(--COLOUR__SWITCH_1)}#obs_pdb_summary table>tbody>tr:nth-child(2n){background-color:var(--COLOUR__SWITCH_3)}#exploreCC_2d_menu>div:nth-child(2){text-align:center}.node rect{stroke:#333;fill:#fff;cursor:pointer}.edgePath path{stroke:#333;stroke-width:1.5px}#mine_better_struct>:first-child{opacity:1!important}@media only screen and (max-width:75em){#mine_better_struct>:first-child>:nth-child(1)>div{font-size:1.1vw!important}}#mine_better_struct>:first-child>:nth-child(1)>div{max-height:1em;font-size:.74vw}#explorePDBTab_strucdet_seqmod table{width:100%;max-width:50em;margin-left:1em}#explorePDBTab_strucdet_seqmod table th{text-align:left}#explorePDBTab_strucdet_seqmod table td:first-child,#explorePDBTab_strucdet_seqmod table td:nth-child(2){width:11em}.mine_pmabs{text-align:justify;text-justify:inter-word}</style><link rel="canonical" href="https://pdbj.org/mine/summary/8p3j" /><link rel="alternate" href="https://pdbj.org/mine/summary/8p3j" hreflang="x-default" /><link rel="alternate" href="https://pdbj.org/mine/summary/8p3j?lang=ja" hreflang="ja" /><link rel="alternate" href="https://pdbj.org/mine/summary/8p3j?lang=zh-CN" hreflang="zh-CN" /><link rel="alternate" href="https://pdbj.org/mine/summary/8p3j?lang=zh-TW" hreflang="zh-TW" /><link rel="alternate" href="https://pdbj.org/mine/summary/8p3j?lang=ko" hreflang="ko" /> <meta charset="utf-8"><meta name="description" content="8p3j: fusion hslp2-a_rab27a non-covalent complex with hit fragment imp-1704"><meta name="thumbnail" content="/molmil-images/mine/8p3j"><title>8p3j - Fusion hSlp2-a_Rab27A non-covalent complex with hit fragment IMP-1704 - Summary - Protein Data Bank Japan</title></head> <body> <img alt="Loading" src="/newweb/media/loading.png" id="loadingImg" class="vis"><div id="pageDIV"><header><div><a href="/"><img id="pdbjHeaderImg" src="/newweb/media/pdbj_logo.svg" alt="PDBj"></a><div class="unselectableText"><span onclick="newweb.call('core.lang_btn_click',this,event)"></span><span><a title="English" onclick="newweb.call('core.lang_click',this,event)" data-lang="en">English</a><a title="日本語" onclick="newweb.call('core.lang_click',this,event)" data-lang="ja">日本語</a><a title="简体中文" onclick="newweb.call('core.lang_click',this,event)" data-lang="zh-CN">简体中文</a><a title="繁體中文" onclick="newweb.call('core.lang_click',this,event)" data-lang="zh-TW">繁體中文</a><a title="한국어" onclick="newweb.call('core.lang_click',this,event)" data-lang="ko">한국어</a></span></div><div class="fancySearch" id="topSearchBox"><span title="Search" onclick="newweb.call('core.omniSearchClick',this,event)"><svg xmlns="http://www.w3.org/2000/svg" width="100%" height="100%" viewBox="0 0 100 100"><circle cx="33" cy="33" r="22"></circle><ellipse cx="67" cy="67" rx="8" ry="25" transform="rotate(-45, 67, 67)"></ellipse></svg></span><input type="text" title="Search pdbj.org" placeholder="Search pdbj.org" data-name="EVERYTHING" onfocus="newweb.call('core.oS_focus',this,event)" onblur="newweb.call('core.oS_blur',this,event)" onkeydown="newweb.call('core.oS_keydown',this,event)" onkeyup="newweb.call('core.oS_keyup',this,event)"><div><div class="closeButton" title="Close" onclick="newweb.call('core.oS_close',this,event)">✖</div><div></div></div></div><div class="unselectableText"><span onclick="newweb.call('core.toggleMenu',this,event)"><svg xmlns="http://www.w3.org/2000/svg"><path d="M4,10h24c1.104,0,2-0.896,2-2s-0.896-2-2-2H4C2.896,6,2,6.896,2,8S2.896,10,4,10z M28,14H4c-1.104,0-2,0.896-2,2 s0.896,2,2,2h24c1.104,0,2-0.896,2-2S29.104,14,28,14z M28,22H4c-1.104,0-2,0.896-2,2s0.896,2,2,2h24c1.104,0,2-0.896,2-2 S29.104,22,28,22z" fill="red"></path></svg><span> Menu</span></span><a href="https://www.facebook.com/PDBjapan" target="_blank" rel="noopener"><img src="/newweb/media/icons/fbicon_32.png" title="PDBj@Facebook" alt="PDBj@Facebook" width="32" height="32"></a><a href="https://x.com/PDBj_en" target="_blank" rel="noopener"><img src="/newweb/media/icons/xicon_32.png" title="PDBj@X(formerly Twitter)" alt="PDBj@X(formerly Twitter)" width="32" height="32"></a><a href="https://bsky.app/profile/pdbjen.bsky.social" target="_blank" rel="noopener"><img src="/newweb/media/icons/bsicon_32.png" title="PDBj@BlueSky" alt="PDBj@BlueSky" width="32" height="32"></a><a href="https://www.youtube.com/user/PDBjmovie" target="_blank" rel="noopener"><img src="/newweb/media/icons/yt_icon.png" title="PDBj@YouTube" alt="PDBj@YouTube" width="64" height="64"></a><a href="https://foundation.wwpdb.org/" target="_blank" rel="noopener" class="wwpdb_foundation_img"><img src="/newweb/media/wwpdb_foundation.png" title="wwPDB Foundation" alt="wwPDB Foundation" width="109" height="32"></a><a href="https://wwpdb.org/" target="_blank" rel="noopener" class="wwpdb_img"><img src="/newweb/media/wwpdb_logo.png" title="wwPDB" alt="wwPDB" width="187" height="58"></a><a href="https://pdbj.org/info/donation" target="_blank" rel="noopener"><img src="/newweb/media/wani.png" title="Donate" alt="Donate" width="187" height="58"></a></div><div><a title="RCSB Protein Data Bank" href="https://www.rcsb.org/" target="_blank" rel="noopener">RCSB PDB</a><a title="Protein Data Bank in Europe" href="https://www.ebi.ac.uk/pdbe/" target="_blank" rel="noopener">PDBe</a><a title="Biological Magnetic Resonance Data Bank" href="https://bmrb.io/" target="_blank" rel="noopener">BMRB</a><a title="PDBj Advanced search" href="/rdb/build">Adv. Search</a><a title="PDBj Omni Search Help" href="/help/omni-search">Search help</a></div></div></header><div><main id=""><div class="tabbedPlane"><a title="Summary" href="/mine/summary/8p3j" id="tab_summary" class="tab_sel">Summary</a><a title="Structural details" href="/mine/structural_details/8p3j" id="tab_structural_details">Structural details</a><a title="Experimental details" href="/mine/experimental_details/8p3j" id="tab_experimental_details">Experimental details</a><a title="Functional details" href="/mine/functional_details/8p3j" id="tab_functional_details">Functional details</a><a title="Sequence Neighbor" href="/mine/seq_neigh/8p3j" id="tab_seq_neigh">Sequence Neighbor</a><a title="History" href="/mine/history/8p3j" id="tab_history">History</a><a title="Downloads" href="/mine/resources/8p3j" id="tab_resources">Downloads</a></div><div id="PDBExplorerPlane" data-pdbid="8p3j" data-lang="en"><h1>8P3J</h1><h2>Fusion hSlp2-a_Rab27A non-covalent complex with hit fragment IMP-1704</h2></div><div id="explorePDBTab_summary"><div class="sNP" id="explorePDBTab_summary_sum"><div>Summary for 8P3J</div><div><table><tbody><tr><td>Entry DOI</td><td><a target="_blank" href="http://dx.doi.org/10.2210/pdb8p3j/pdb">10.2210/pdb8p3j/pdb</a></td></tr><tr><td>Descriptor</td><td><span property="PDBo:entity.pdbx_description">Synaptotagmin-like protein 2,Ras-related protein Rab-27A, ~{N}-(4-pyrrolidin-1-ylsulfonylphenyl)prop-2-enamide, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (<a href="/mine/structural_details/8p3j">6 entities in total</a>)</span></td></tr><tr><td>Functional Keywords</td><td>small gtpase, targeted covalent inhibitors, high throughput screening, drug discovery, vesicle trafficking, breast cancer, cytosolic protein</td></tr><tr><td>Biological source</td><td>Homo sapiens (human)<br><a title="More" href="/mine/structural_details/8p3j">More</a></td></tr><tr><td>Total number of polymer chains</td><td>2</td></tr><tr><td>Total formula weight</td><td><a title="54254.95" href="/mine/structural_details/8p3j">54254.95</a></td></tr><tr><td>Authors</td><td><div><span property="PDBo:audit_author.name"><a href="/search/pdb-author?query=%22De%20Vita,%20E.%22">De Vita, E.</a>,<a href="/search/pdb-author?query=%22Brustur,%20D.%22">Brustur, D.</a>,<a href="/search/pdb-author?query=%22Tersa,%20M.%22">Tersa, M.</a>,<a href="/search/pdb-author?query=%22Petracca,%20R.%22">Petracca, R.</a>,<a href="/search/pdb-author?query=%22Morgan,%20R.M.L.%22">Morgan, R.M.L.</a>,<a href="/search/pdb-author?query=%22Lanyon-Hogg,%20T.%22">Lanyon-Hogg, T.</a>,<a href="/search/pdb-author?query=%22Norman,%20J.C.%22">Norman, J.C.</a>,<a href="/search/pdb-author?query=%22Cota,%20E.%22">Cota, E.</a>,<a href="/search/pdb-author?query=%22Tate,%20E.W.%22">Tate, E.W.</a></span> (deposition date: <span property="PDBo:pdbx_database_status.recvd_initial_deposition_date">2023-05-17</span>, release date: <span property="dateCreated">2024-11-20</span>)</div></td></tr><tr><td>Primary citation</td><td>De Vita, E.,Brustur, D.,Tersa, M.,Petracca, R.,Morgan, R.M.L.,Lanyon-Hogg, T.,Norman, J.C.,Cota, E.,Tate, E.W.<br><b>Targeted covalent inhibitors of the small GTPase Rab27A</b><br><i>To Be Published</i>, <br></td></tr><tr><td>Experimental method</td><td><div><span property="PDBo:exptl.method">X-RAY DIFFRACTION</span> (<span property="PDBo:refine.ls_d_res_high">2.16 Å</span>)<br></div></td></tr></tbody></table></div></div><div class="sNP" id="explorePDBTab_summary_validation"><div>Structure validation</div><div><img src="https://data.pdbj.org/pub/pdb/validation_reports/p3/8p3j/8p3j_multipercentile_validation.svg" height="420" alt="Validation report summary of 8p3j"><div>Download <a href="https://data.pdbj.org/pub/pdb/validation_reports/p3/8p3j/8p3j_full_validation.pdf" target="_blank">full validation report<img alt="Download" src="/newweb/media/icons/dl.png" width="32" height="32"></a></div></div></div></div></main><aside id="contentMenu_explorePDB"><div class="sNP" id="explorePDB_dl_menu"><div>Downloads</div><div><table><tbody><tr><td><a href="/display/pdb/fasta/8p3j" target="mD_*"><img alt="Download" title="Display" src="/newweb/media/icons/view.png" width="32" height="32"></a></td><td><a href="rest/newweb/fetch/file?cat=pdb&type=fasta&id=8p3j" download=""><img alt="View" title="Download" src="/newweb/media/icons/dl.png" width="32" height="32"></a></td><td>Sequence (fasta)</td></tr><tr><td><a href="/display/pdb/mmcif/8p3j" target="mD_*"><img alt="Download" title="Display" src="/newweb/media/icons/view.png" width="32" height="32"></a></td><td><a href="https://data.pdbj.org/pub/pdb/data/structures/divided/mmCIF/p3/8p3j.cif.gz" download=""><img alt="View" title="Download" src="/newweb/media/icons/dl.png" width="32" height="32"></a></td><td>PDBx/mmCIF</td></tr><tr><td><a href="/display/pdb/pdbml-noatom/8p3j" target="mD_*"><img alt="Download" title="Display" src="/newweb/media/icons/view.png" width="32" height="32"></a></td><td><a href="https://data.pdbj.org/pub/pdb/data/structures/divided/XML-noatom/p3/8p3j-noatom.xml.gz" download=""><img alt="View" title="Download" src="/newweb/media/icons/dl.png" width="32" height="32"></a></td><td>PDBML format (no-atom)</td></tr><tr><td><a href="/display/pdb/pdb/8p3j" target="mD_*"><img alt="Download" title="Display" src="/newweb/media/icons/view.png" width="32" height="32"></a></td><td><a href="https://data.pdbj.org/pub/pdb/data/structures/divided/pdb/p3/pdb8p3j.ent.gz" download=""><img alt="View" title="Download" src="/newweb/media/icons/dl.png" width="32" height="32"></a></td><td>PDB format (full)</td></tr><tr><td><a href="https://data.pdbj.org/pub/pdb/validation_reports/p3/8p3j/8p3j_full_validation.pdf" target="mD_*"><img alt="Download" title="Display" src="/newweb/media/icons/view.png" width="32" height="32"></a></td><td><a href="https://data.pdbj.org/pub/pdb/validation_reports/p3/8p3j/8p3j_full_validation.pdf.gz" download=""><img alt="View" title="Download" src="/newweb/media/icons/dl.png" width="32" height="32"></a></td><td>Validation report (PDF)</td></tr><tr><td><a href="/molmil2/#fetch%208p3j;%20repr%20sticks;%20style-if%20edmap,%202fo-fc;" target="mD_*"><img alt="Download" title="Display" src="/newweb/media/icons/view.png" width="32" height="32"></a></td><td><a href="https://data.pdbj.org/pdbjplus/edmap2/mtz/8p3j_validation_2fo-fc_map_coef.mtz" download=""><img alt="View" title="Download" src="/newweb/media/icons/dl.png" width="32" height="32"></a></td><td>EDMap 2fo-fc (MTZ)</td></tr></tbody></table><a title="More..." href="/mine/resources/8p3j">More...</a></div></div><div class="sNP" id="contentMenu_explorePDB_topol"><a title="Chain topology" href="/mine/chain-topology/8p3j" target="mD_*">Chain topology</a><div></div></div><div class="sNP" id="explorePDB_3d"><div>Structures</div><div><a title="" href="/molmil2/#fetch 8p3j; repr au; style-if structure;" target="_blank" rel="noopener"><span>View Asymmetric Unit</span><img alt="AU of 8p3j by Molmil" width="256" height="256" src="/molmil-images/mine/8p3j.png"></a></div></div><div class="sNP" id="explorePDB_dbinfo_menu"><div>Database information</div><div><a title="wwPDB DOI Landing Page" href="https://www.wwpdb.org/pdb?id=pdb_00008p3j" target="_blank" rel="noopener">wwPDB DOI Landing Page</a><a title="CATH" href="http://www.cathdb.info/pdb/8p3j" target="_blank" rel="noopener">CATH</a><a title="VAST" href="https://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?uid=8p3j" target="_blank" rel="noopener">VAST</a><a title="PISA" href="//www.ebi.ac.uk/msd-srv/pisa/cgi-bin/piserver?qi=8p3j" target="_blank" rel="noopener">PISA</a><div title="eF-site">eF-site<a title="8p3j-A,B" href="/molmil2/#efsite 8p3j-A,B; repr neutral; style-if sites;" target="_blank" rel="noopener">8p3j-A,B</a><a title="8p3j-A" href="/molmil2/#efsite 8p3j-A; repr neutral; style-if sites;" target="_blank" rel="noopener">8p3j-A</a><a title="8p3j-B" href="/molmil2/#efsite 8p3j-B; repr neutral; style-if sites;" target="_blank" rel="noopener">8p3j-B</a></div><a title="Electron Density Map" href="/molmil2/#fetch 8p3j; repr sticks; style-if edmap, both;" target="_blank" rel="noopener">Electron Density Map</a><a title="wwPDB/RDF" href="https://rdf.wwpdb.org/pdb/8P3J" target="_blank" rel="noopener">wwPDB/RDF</a><a title="UniProt" href="/uniprot/?query=accession:Q9HCH5%20OR%20accession:P51159">UniProt</a><div title="KEGG">KEGG<a title="3.6.5.2" href="http://www.genome.jp/dbget-bin/www_bget?ec:3.6.5.2" target="_blank" rel="noopener">3.6.5.2</a></div><div title="ExPASy">ExPASy<a title="3.6.5.2" href="http://enzyme.expasy.org/EC/3.6.5.2" target="_blank" rel="noopener">3.6.5.2</a></div><div title="IUBMB">IUBMB<a title="3.6.5.2" href="https://www.qmul.ac.uk/sbcs/iubmb/enzyme/EC3/6/5/2.html" target="_blank" rel="noopener">3.6.5.2</a></div><div title="Pfam">Pfam<a title="PF02318" href="https://www.ebi.ac.uk/interpro/entry/pfam/PF02318/" target="_blank" rel="noopener">PF02318</a><a title="PF00071" href="https://www.ebi.ac.uk/interpro/entry/pfam/PF00071/" target="_blank" rel="noopener">PF00071</a></div><div title="Promode Elastic">Promode Elastic<a title="8p3j" href="/promode-elastic/8p3j">8p3j</a><a title="8p3jA" href="/promode-elastic/8p3jA">8p3jA</a><a title="8p3jB" href="/promode-elastic/8p3jB">8p3jB</a></div></div></div></aside><footer><div class="sPlane"><div><a title="Help" href="/help">Help</a><a title="Contact us" href="/contact">Contact us</a><a title="Terms and Conditions" href="/info/terms-conditions">Terms and Conditions</a><a title="Privacy policy" href="/info/privacy-policy">Privacy policy</a></div><hr><div></div><span><img alt="PDBj" width="300" height="114" src="/newweb/media/default.svg"> is supported by <img alt="JST" width="102" height="88" src="/newweb/media/jst_logo.svg"><img alt="NBDC" width="345" height="114" src="/newweb/media/nbdc_logo.svg"> and is a member of <a href="https://jbioinfo.jp/" target="blank" rel="nofollow noopener"><img alt="JBI" width="219" height="61" src="/newweb/media/jbi.png"></a></span><hr><div>Copyright © 2013-2025 Protein Data Bank Japan</div></div></footer></div><nav id="sideMenu"><div class="sNP sNPex" id="sideMenu_HOME"><div onclick="newweb.call('core.explane_click',this,event)">Home</div><ul><li data-desc="PDBj top page" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="Top Page" href="/">Top Page</a></li><li data-desc="Statistics for PDB content distribution and growth" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="Statistics" href="/info/statistics">Statistics</a></li><li data-desc="Help documents for each PDBj service" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="Help" href="/help">Help</a></li><li data-desc="Frequently asked questions" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="FAQ" href="/help/faq">FAQ</a></li><li data-desc="Contact Protein Data Bank Japan" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="Contact Us" href="/contact">Contact Us</a></li><li data-desc="Cite PDBj, our services or PDB entries and Terms and Conditions" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="Cite Us / Terms and Conditions" href="/info/cite-us">Cite Us / Terms and Conditions</a></li><li data-desc="Links to related organizations" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="Links" href="/info/links">Links</a></li><li data-desc="PDBj settings" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="Settings" href="/settings">Settings</a></li></ul></div><div class="sNP sNPex" id="sideMenu_DATA_DEPOSITION"><div onclick="newweb.call('core.explane_click',this,event)">Data deposition (OneDep)</div><ul><li data-desc="About data deposition" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="Help" href="/info/data-deposition">Help</a></li><li data-desc="Deposit structures determined by X-ray diffraction, Electron Microscopy or NMR method" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="Deposition to PDB, EMDB or BMRB" href="https://deposit-pdbj.wwpdb.org/deposition" target="_blank" rel="noopener">Deposition to PDB, EMDB or BMRB</a></li></ul></div><div class="sNP sNPex" id="sideMenu_DATA_DOWNLOAD"><div onclick="newweb.call('core.explane_click',this,event)">Download</div><ul><li data-desc="Download PDB data using FTP or rsync protocol" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="Download PDB archive / snapshot archive" href="/info/archive">Download PDB archive / snapshot archive</a></li></ul></div><div class="sNP sNPex" id="sideMenu_NEW_FORMAT"><div onclick="newweb.call('core.explane_click',this,event)">Standard format</div><ul><li data-desc="Browse PDBx/mmCIF Resources" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="PDBx/mmCIF Resources" href="/info/new-format">PDBx/mmCIF Resources</a></li><li data-desc="Convert the PDB format and PDBx/mmCIF files to the other format." onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="Format Conversion" href="https://mmcif.pdbj.org/converter/index.php?l=en" target="_blank" rel="noopener">Format Conversion</a></li><li data-desc="Modify, merge and validate PDBx/mmCIF and other STAR-formatted files" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="PDBx/mmCIF editor" href="/cif-editor/" target="_blank" rel="noopener">PDBx/mmCIF editor</a></li></ul></div><div class="sNP sNPex" id="sideMenu_QUICK_LINKS"><div onclick="newweb.call('core.explane_click',this,event)">Quick links</div><ul><li><a title="Help" href="/help/quick-links-menu" target="mD_*">Help</a></li><li data-desc="Show list of non-PDB format compatible entries" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="non-PDB format compatible" href="/list/pdb-legacy-incompatible">non-PDB format compatible</a></li><li data-desc="Show list of Group Depositions entries" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="Group Depositions" href="/list/pdb-group-depositions">Group Depositions</a></li><li data-desc="Show list of chemical component entries (chem_comp)" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="Chemical Component entries" href="/search/chemie?query=*">Chemical Component entries</a></li><li data-desc="Show latest released or updated entries" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="Latest entries" href="/pdbj-update">Latest entries</a></li></ul></div><div class="sNP sNPex" id="sideMenu_SEARCH"><div onclick="newweb.call('core.explane_click',this,event)">Search services</div><ul><li><a title="Help" href="/help/search-menu" target="mD_*">Help</a></li><li data-desc="Search using PDBj Mine (old advanced search)" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="Search PDB (PDBj Mine)" href="/search/pdb-filter">Search PDB (PDBj Mine)</a></li><li data-desc="Search using PDBj Mine (advanced search)" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="Search PDBj RDB" href="/rdb/build">Search PDBj RDB</a></li><li data-desc="Search chemical entries (chem_comp)" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="Chemie search" href="/search/chemie-filter">Chemie search</a></li><li data-desc="Search entries in the biomolecule NMR database BMRB" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="Search BMRB" href="https://bmrbj.pdbj.org/index_en.html" target="_blank" rel="noopener">Search BMRB</a></li><li data-desc="Search molecules with similar sequences" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="Sequence-Navigator" href="/seqnavi">Sequence-Navigator</a></li><li data-desc="Search molecules with similar structures (replaces Structure Navigator)" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="DASH" href="/info/dash">DASH</a></li><li data-desc="Browse 3D electron microscopy (3D-EM) data of biological molecules and assemblies" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="EM Navigator" href="/emnavi/" target="_blank" rel="noopener">EM Navigator</a></li><li data-desc="Shape similarity search of macromolecules" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="Omokage search" href="/emnavi/omo-search.php?lang=en" target="_blank" rel="noopener">Omokage search</a></li><li data-desc="Sequence-Derived Structural Alignment Weights --- Search functional annotations that identifies conserved sequence and structural motifs in query proteins" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="SeSAW" href="/info/sesaw">SeSAW</a></li><li data-desc="Search PDB data in RDF format" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="wwPDB/RDF" href="https://rdf.wwpdb.org/" target="_blank" rel="noopener">wwPDB/RDF</a></li><li data-desc="SPARQL endpoints for comprehensive RDF graphs" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="RDF Portal" href="https://rdfportal.org" target="_blank" rel="noopener">RDF Portal</a></li><li data-desc="Search status of unreleased PDB entries" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="Status search" href="/search/status-filter">Status search</a></li></ul></div><div class="sNP sNPex" id="sideMenu_MOLECULAR_VIEWERS"><div onclick="newweb.call('core.explane_click',this,event)">Molecular Viewers</div><ul><li><a title="Help" href="/help/molecular-viewers" target="mD_*">Help</a></li><li data-desc="About jV, an interactive 3D viewer program to visualize structure of protein and nucleic acid molecules" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="jV: Graphic Viewer" href="/jv/index.html" target="_blank" rel="noopener">jV: Graphic Viewer</a></li><li data-desc="Molmil, a new molecular viewer developed for a web environment with the intent to be usable on as many platforms as possible" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="Molmil: WebGL Mol. Viewer" href="/help/molmil">Molmil: WebGL Mol. Viewer</a></li></ul></div><div class="sNP sNPex" id="sideMenu_GSS"><div onclick="newweb.call('core.explane_click',this,event)">Services & Softwares</div><ul><li><a title="Help" href="/help/service-software-menu" target="mD_*">Help</a></li><li data-desc="Watch, move and enjoy 3D structures of biological molecules" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="Yorodumi" href="/emnavi/quick.php?" target="_blank" rel="noopener">Yorodumi</a></li><li data-desc="Perform three-dimensional structure alignment" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="ASH" href="/info/ash">ASH</a></li><li data-desc="Calculates multple sequence alignments from sequences and structures" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="MAFFTash" href="/info/mafftash">MAFFTash</a></li><li data-desc="Download NMR related Tools" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="NMRToolBox" href="https://bmrbj.pdbj.org/en/nmr_tool_box.html" target="_blank" rel="noopener">NMRToolBox</a></li><li data-desc="A superimposition program of atomic models and 3D density maps" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="gmfit" href="/gmfit/" target="_blank" rel="noopener">gmfit</a></li><li data-desc="Predicts one-dimensional protein structures from amino acid sequence" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="CRNPRED" href="/crnpred/" target="_blank" rel="noopener">CRNPRED</a></li><li data-desc="A structural homology modeling program which threads a specific amino-acid sequence onto a specific PDB structure" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="Spanner" href="/info/spanner">Spanner</a></li><li data-desc="Sequence to Function Annotation Server, for predicting the structure of an amino acid sequence" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="SFAS" href="/info/sfas">SFAS</a></li><li data-desc="Finding and modeling of 3D structures of complexes" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="HOMCOS" href="https://homcos.pdbj.org/?LANG=en" target="_blank" rel="noopener">HOMCOS</a></li></ul></div><div class="sNP sNPex" id="sideMenu_DDB"><div onclick="newweb.call('core.explane_click',this,event)">Derived databases</div><ul><li><a title="Help" href="/help/derived-databases-menu" target="mD_*">Help</a></li><li data-desc="Electrostatic-surface of Functional site, a database for molecular surfaces of proteins' functional sites" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="eF-site" href="/eF-site/" target="_blank" rel="noopener">eF-site</a></li><li data-desc="A web server to search for the similar ligand binding sites for the uploaded coordinate file" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="eF-seek" href="/eF-seek/top.do" target="_blank" rel="noopener">eF-seek</a></li><li data-desc="A web service to calculate the molecular surface of the up-loaded file" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="eF-surf" href="/eF-surf/top.do" target="_blank" rel="noopener">eF-surf</a></li><li data-desc="A database of NMA of PDB data using elastic network model in torsional angle space" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="ProMode Elastic" href="/promode-elastic">ProMode Elastic</a></li></ul></div><div class="sNP sNPex" id="sideMenu_ES"><div onclick="newweb.call('core.explane_click',this,event)">Educational service</div><ul><li><a title="Help" href="/help/educational-services-menu" target="mD_*">Help</a></li><li data-desc="Encyclopedia of Protein Structures, a dictionary with pictures of the protein three-dimensional structures" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="eProtS" href="/info/eprots">eProtS</a></li><li data-desc="Introduction to biological macromolecules written by Dr. David S. Goodsell of RCSB" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="Molecule of the Month" href="https://pdb101.rcsb.org/motm/" target="_blank" rel="noopener">Molecule of the Month</a></li><li data-desc="Material of previous workshops such as handouts and movies" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="Previous workshop" href="/info/previous-workshop">Previous workshop</a></li><li data-desc="The snake game of amino acid and the pelmanism of amino acid/protein" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="Games" href="/games">Games</a></li><li data-desc="Make molecule models with paper" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="Papermodels" href="https://numon.pdbj.org/papermodel/?l=en" target="_blank" rel="noopener">Papermodels</a></li></ul></div><div class="sNP sNPex" id="sideMenu_ABOUT"><div onclick="newweb.call('core.explane_click',this,event)">About PDBj</div><ul><li><a title="Help" href="/help/customizations" target="mD_*">Help</a></li><li data-desc="The list of papers and books involved in PDBj" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="Publications" href="/info/publications">Publications</a></li><li data-desc="The newsletters and public relations resources published by PDBj" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="Newsletters / Public Relations Resources" href="/info/publicresources">Newsletters / Public Relations Resources</a></li><li data-desc="The list of the PDBj members" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="PDBj Members" href="/info/staff">PDBj Members</a></li><li data-desc="The list of the PDBj Advisory Committee" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="PDBj Advisory Committee" href="/info/pdbjac">PDBj Advisory Committee</a></li><li data-desc="About the privacy policy" onmouseover="newweb.call('core.menu_mouseover',this,event)" onmouseout="newweb.call('core.menu_mouseout',this,event)"><a title="Privacy Policy" href="/info/privacy-policy">Privacy Policy</a></li></ul></div></nav><span id="pdbInfoBox"><div><p>234136</p><p>PDB entries from 2025-04-02</p><a href="/info/statistics"><img alt="PDB statistics" width="72" height="72" src="/newweb/media/statistics.png"></a><a href="/pdbj-update"><img alt="PDBj update info" width="72" height="72" src="/newweb/media/pdbj-update.png"></a><a href="/contact"><img alt="Contact PDBj" width="72" height="72" src="/newweb/media/contact.png"></a><a href="//numon.pdbj.org" target="_blank" rel="nofollow noopener"><img alt="numon" width="72" height="72" src="/newweb/media/numon_en.png"></a></div></span></div><div class="sNP opacityTransition" id="infoBox"><div></div><div></div></div><script fetchpriority="low" type="module" src="./newweb/js/core.js"></script><script fetchpriority="low" type="module" src="./newweb/js/mine.js"></script><script nomodule src="./newweb/js/legacy.js"></script></body></html>