Pipeline - NMS Portfolio - Nerviano Medical Sciences

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e-parent" data-id="1ae74c5" data-element_type="container" data-settings="{"background_background":"classic"}"> <div class="e-con-inner"> <div class="elementor-element elementor-element-5ac6edc elementor-widget elementor-widget-heading" data-id="5ac6edc" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h3 class="elementor-heading-title elementor-size-default">Continuously Evolving Our NMS Portfolio: <br>Proven Success, Driven by Ongoing Innovation </h3> </div> </div> <div class="elementor-element elementor-element-081c35b elementor-widget__width-initial elementor-widget-divider--view-line elementor-widget elementor-widget-divider" data-id="081c35b" data-element_type="widget" data-widget_type="divider.default"> <div class="elementor-widget-container"> <div class="elementor-divider"> <span class="elementor-divider-separator"> </span> </div> </div> </div> <div class="elementor-element elementor-element-a2b7ba8 elementor-widget elementor-widget-text-editor" data-id="a2b7ba8" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Building on our legacy of Oncology expertise, we are advancing innovative<br />Small Molecule and ADC platforms to drive our strategic focus</p> </div> </div> </div> </div> <div class="elementor-element elementor-element-18f33cd e-flex e-con-boxed e-con e-parent" data-id="18f33cd" data-element_type="container" data-settings="{"background_background":"classic"}"> <div class="e-con-inner"> <div class="elementor-element elementor-element-b1df83b print-no elementor-widget elementor-widget-html" data-id="b1df83b" data-element_type="widget" data-widget_type="html.default"> <div class="elementor-widget-container"> <section class="padded pipeline-section waypointed"> <div class="inner-container"> <div class="pipeline-wrap"> <div class="expand"><a href="javascript:void(0);" id="expandAll">+ Expand All</a></div> <table class="pipeline" border="0" cellspacing="0" cellpadding="0" style="margin:0;overflow:hidden;"> <tbody> <tr class="pipeline-header"> <td class="vertical-column"> </td> <td class="program"> <div class="table-label">Program </div> </td> <td class="target"> <div class="table-label">ASSET (Target)</div> </td> <td class="indication"> <div class="table-label">PARTNER / LICENSE</div> </td> <td class="preclinical smaller border-right-bg dash-right solid-left"> <div class="table-label">DISCOVERY</div> </td> <td class="phase-1 smaller border-right-bg dash-right "> <div class="table-label">IND/ PRE-CLINICAL</div> </td> <td class="phase-2 smaller border-right-bg dash-right "> <div class="table-label">Phase I </div> </td> <td class="phase-3 smaller dash-right "> <div class="table-label">Phase II </div> </td> <td class="phase-4 smaller no-left"> <div class="table-label">Phase III </div> </td> </tr> <tr class="data green-grad"> <td rowspan="15" style="vvertical-align: middle;background-color: #BF0000!important;text-align: center;padding: 16px;border-bottom: 10px solid #d0cece;"> <div class="vertical-text"> <div class="content">Small Molecules</div> </div> </td> <td class="program" rowspan="11" style="vertical-align: middle;"> <div class="table-label">Kinases</div> </td> <td class="target"> <div class="table-label"> <a href="#" class="target-info-toggle"> <img decoding="async" src="/wp-content/uploads/2024/10/plus.svg"> <strong>Encorafenib</strong> <br>(BRAF) </a> </div> </td> <td class="indication" style=""><div style="width: 50%; float: left; line-height: 52px;text-align: center;margin-bottom: -10px;"><img decoding="async" src="https://www.nervianoms.com/wp-content/uploads/2024/10/Pfizer_2021.svg" style="height: 24px;"></div><div style="width: 50%; float: left; line-height: 52px;text-align: center;margin-bottom: -10px;"><picture decoding="async" style="height: 16px;" class="print-no"> <source type="image/webp" srcset="https://www.nervianoms.com/wp-content/uploads/2024/10/array_biopharma_inc__logo.png.webp"/> <img decoding="async" src="https://www.nervianoms.com/wp-content/uploads/2024/10/array_biopharma_inc__logo.png"/> </picture> </div><div style=" width: 100%;float: left; text-align: center; margin-bottom: -10px;margin-top: -10px;"><picture decoding="async" style="height: 50px;" class="owl"> <source type="image/webp" srcset="https://www.nervianoms.com/wp-content/uploads/2024/10/Blue_Owl_Capital_Corporation_Logo.png.webp"/> <img decoding="async" src="https://www.nervianoms.com/wp-content/uploads/2024/10/Blue_Owl_Capital_Corporation_Logo.png"/> </picture> </div><span class="logo-label">Exclusive</span></td> <td class="preclinical smaller dash-right solid-left" style="height: 100px!important;position: relative; "> <div class="arrow shrank -grad" style="width: calc(200% + 310% - 25px);top: -60px;"><span class="text">BRAF Mutated Melanoma Combo</span><span class="circle"> </span></div> <div class="arrow shrank -grad" style="width: calc(200% + 310% - 25px);top: 0px;"><span class="text">BRAF Mutated CRC Combo</span> <span class="circle"> </span></div> <div class="arrow shrank -grad" style="width: calc(200% + 310% - 25px);top: 60px;"><span class="text">BRAF Mutated NSCLC Combo</span> <span class="circle"> </span></div> </td> <td class="phase-1 smaller dash-right"></td> <td class="phase-2 smaller dash-right"></td> <td class="phase-3 smaller dash-right"></td> <td class="phase-3 smaller no-left"></td> </tr> <tr class="target-info" id="first-active"><td colspan="7" style="color:#000; display: none;" id="pipeline_encorafenib"> <p>Encorafenib, BRAF inhibitor used in combination for BRAF mutated melanoma, colorectal cancer, non-small cell lung cancer, globally commercialized as BRAFTOVI®. NMS licensed out enabling IP rights, and in 2024, signed a royalty agreement with Blue Owl Capital. </p> <div class="elementor-widget-container"> <div class="elementor-button-wrapper"> <a class="elementor-button elementor-button-link elementor-size-sm" href="#encorafenib"> <span class="elementor-button-content-wrapper"> <span class="elementor-button-icon" style="padding-top: 3px;"> <picture decoding="async" style="width: 25px;"> <source type="image/webp" srcset="/wp-content/uploads/2024/10/arrow-1.png.webp"/> <img decoding="async" src="/wp-content/uploads/2024/10/arrow-1.png"/> </picture> </span> <span class="elementor-button-text" style=" font-size: 1rem; color: #000; ">More Information</span> </span> </a> </div> </div> </td></tr> <tr class="data green-grad" id="pipeline_entrectinib"> <td class="target"> <div class="table-label"> <a href="#" class="target-info-toggle"> <img decoding="async" src="/wp-content/uploads/2024/10/plus.svg"> <strong>Entrectinib</strong> <br>(TRK, ROS) </a> </div> </td> <td class="indication"><div style="width: 50%;float: left;/* line-height: 52px; */text-align: right;padding-right: 3px; margin-bottom: -14px;"><picture decoding="async" style="height: 40px;" class="ignyta"> <source type="image/webp" srcset="https://www.nervianoms.com/wp-content/uploads/2024/10/ignyta.png.webp"/> <img decoding="async" src="https://www.nervianoms.com/wp-content/uploads/2024/10/ignyta.png"/> </picture> </div> <div style="width: 50%;float: left;line-height: 52px;text-align: left;padding-left: 7px; margin-bottom: -14px;"><picture decoding="async" style="height: 24px;" class="roche"> <source type="image/webp" srcset="https://www.nervianoms.com/wp-content/uploads/2024/10/Hoffmann-La_Roche_logo.svg.png.webp"/> <img decoding="async" src="https://www.nervianoms.com/wp-content/uploads/2024/10/Hoffmann-La_Roche_logo.svg.png"/> </picture> </div><span class="logo-label">Exclusive</span></td> <td class="preclinical smaller dash-right solid-left"> <div class="arrow shrank -grad" style="width: calc(200% + 280% - 25px);top: -30px;"><span class="text">ROS Mutated NSCLC</span> <span class="circle" style="right:110px;"> </span></div> <div class="arrow shrank -grad" style="width: calc(200% + 280% - 25px);top: 30px;"><span class="text">TRK Mutated Solid Tumors</span> <span class="circle" style="right:110px;"> </span></div> </td> <td class="phase-1 smaller no-left dash-right"></td> <td class="phase-2 smaller no-left dash-right"></td> <td class="phase-3 smaller dash-right"></td> <td class="phase-3 smaller no-left"></td> </tr> <tr class="target-info"><td colspan="7" style="color: #000; display: none;"> <p>Entrectinib, selective inhibitor of TRK A/B/C, ROS1, and ALK, targeting gene rearrangements that drive tumor growth. Invented by NMS and later licensed to Ignyta, now part of Roche (commercialized under the brand name of ROZLYTREK®). It is approved for patients with NTRK-positive and ROS1-positive metastatic NSCLC, including those with brain metastases, due to its ability to penetrate the blood-brain barrier. </p> <div class="elementor-widget-container"> <div class="elementor-button-wrapper"> <a class="elementor-button elementor-button-link elementor-size-sm" href="#entrectinib"> <span class="elementor-button-content-wrapper"> <span class="elementor-button-icon" style="padding-top: 3px;"> <picture decoding="async" style="width: 25px;"> <source type="image/webp" srcset="/wp-content/uploads/2024/10/arrow-1.png.webp"/> <img decoding="async" src="/wp-content/uploads/2024/10/arrow-1.png"/> </picture> </span> <span class="elementor-button-text" style=" font-size: 1rem; color: #000; ">More Information</span> </span> </a> </div> </div> </td></tr> <tr class="data green-grad" id="pipeline_onvansertib"> <td class="target"> <div class="table-label"> <a href="#" class="target-info-toggle"> <img decoding="async" src="/wp-content/uploads/2024/10/plus.svg"> <strong>Onvansertib</strong> <br>(PLK1) </a> </div> </td> <td class="indication"> <img decoding="async" src="/wp-content/uploads/2024/10/cardiff-logo-color.png" style="height: 40px;"> <br><span class="logo-label" style="margin-top: -8px;">Exclusive</span></td> <td class="preclinical smaller dash-right solid-left"> <div class="arrow shrank -grad" style="width: calc(100% + 280% - 25px);"><span class="text">Solid Tumors Combo</span></div> </td> <td class="phase-1 smaller no-left dash-right"></td> <td class="phase-2 smaller no-left dash-right"></td> <td class="phase-3 smaller dash-right"></td> <td class="phase-3 smaller no-left"></td> </tr> <tr class="target-info"><td colspan="7" style="color: #000; display: none;" > <p>Onvansertib is the first oral, potent, and selective inhibitor of PLK1, a key regulator of cell division overexpressed in cancer cells. Invented by NMS and licensed to Cardiff Oncology, it is currently in Phase I and II clinical trials. </p> <div class="elementor-widget-container"> <div class="elementor-button-wrapper"> <a class="elementor-button elementor-button-link elementor-size-sm" href="#onvansertib"> <span class="elementor-button-content-wrapper"> <span class="elementor-button-icon" style="padding-top: 3px;"> <picture decoding="async" style="width: 25px;"> <source type="image/webp" srcset="/wp-content/uploads/2024/10/arrow-1.png.webp"/> <img decoding="async" src="/wp-content/uploads/2024/10/arrow-1.png"/> </picture> </span> <span class="elementor-button-text" style=" font-size: 1rem; color: #000; ">More Information</span> </span> </a> </div> </div> </td></tr> <tr class="data green-grad" id="pipeline_NMS-153"> <td class="target"> <div class="table-label"> <a href="#" class="target-info-toggle"> <img decoding="async" src="/wp-content/uploads/2024/10/plus.svg"> <strong>NMS-153</strong> <br>(MPS1) </a> </div> </td> <td class="indication"></td> <td class="preclinical smaller dash-right solid-left"> <div class="arrow shrank -grad" style="width: calc(100% + 250% - 25px);"><span class="text">HCC</span></div> </td> <td class="phase-1 smaller no-left dash-right"></td> <td class="phase-2 smaller no-left dash-right"></td> <td class="phase-3 smaller dash-right"></td> <td class="phase-3 smaller no-left"></td> </tr> <tr class="target-info"><td colspan="7" style="color: #000; display: none;" > <p>NMS-153 is a potent, selective inhibitor of MPS1/TTK kinase, targeting mitotic cancer cells and inducing cell death through both mitotic catastrophe and immunogenic mechanisms. Currently in Phase I/II clinical trials for hepatocellular carcinoma, it has demonstrated broad <em>in vivo</em> preclinical efficacy as both a single agent and in combination therapies. </p> <div class="elementor-widget-container"> <div class="elementor-button-wrapper"> <a class="elementor-button elementor-button-link elementor-size-sm" href="#NMS-153"> <span class="elementor-button-content-wrapper"> <span class="elementor-button-icon" style="padding-top: 3px;"> <picture decoding="async" style="width: 25px;"> <source type="image/webp" srcset="/wp-content/uploads/2024/10/arrow-1.png.webp"/> <img decoding="async" src="/wp-content/uploads/2024/10/arrow-1.png"/> </picture> </span> <span class="elementor-button-text" style=" font-size: 1rem; color: #000; ">More Information</span> </span> </a> </div> </div> </td></tr> <tr class="data green-grad" id="pipeline_NMS-812"> <td class="target"> <div class="table-label"> <a href="#" class="target-info-toggle"> <img decoding="async" src="/wp-content/uploads/2024/10/plus.svg"> <div style="width: 150%;"><strong>NMS-812</strong> <br>(PERK/GCN2)</div> </a> </div> </td> <td class="indication"></td> <td class="preclinical smaller dash-right solid-left"> <div class="arrow shrank -grad" style="width: calc(0% + 192% - 5px);"><span class="text">AML</span></div> </td> <td class="phase-1 smaller no-left dash-right"></td> <td class="phase-2 smaller no-left dash-right"></td> <td class="phase-3 smaller dash-right"></td> <td class="phase-3 smaller no-left"></td> </tr> <tr class="target-info"><td colspan="7" style="color: #000; display: none;" > <p>NMS-812 is a novel, potent dual inhibitor of PERK and GCN2, key effectors of the Integrated Stress Response (ISR) pathway that cancer cells exploit to survive stress. Currently in clinical development with a promising pharmacokinetic profile, it holds potential for overcoming drug resistance in oncology, particularly in Acute Myeloid Leukemia (AML). </p> <div class="elementor-widget-container"> <div class="elementor-button-wrapper"> <a class="elementor-button elementor-button-link elementor-size-sm" href="#NMS-812"> <span class="elementor-button-content-wrapper"> <span class="elementor-button-icon" style="padding-top: 3px;"> <picture decoding="async" style="width: 25px;"> <source type="image/webp" srcset="/wp-content/uploads/2024/10/arrow-1.png.webp"/> <img decoding="async" src="/wp-content/uploads/2024/10/arrow-1.png"/> </picture> </span> <span class="elementor-button-text" style=" font-size: 1rem; color: #000; ">More Information</span> </span> </a> </div> </div> </td></tr> <tr class="data green-grad" id="early_pipeline"> <td class="target"> <div class="table-label" style="margin-left: 34px;"> <a href="#" class="target-info-toggle" style="pointer-events: none;"> <strong>Early Pipeline Projects</strong> <br>(Undisclosed) </a> </div> </td> <td class="indication"></td> <td class="preclinical smaller dash-right solid-left"> <div class="arrow shrank -grad" style="width: calc(0% + 20% - 5px);"></div> </td> <td class="phase-1 smaller no-left dash-right"></td> <td class="phase-2 smaller no-left dash-right"></td> <td class="phase-3 smaller dash-right"></td> <td class="phase-3 smaller no-left"></td> </tr> <tr class="data green-grad" id="pipeline_NMS-293"> <td class="program" rowspan="4" style="vertical-align: middle;"> <div class="table-label">NAD+ Binding Family: PARP</div> </td> <td class="target"> <div class="table-label"> <a href="#" class="target-info-toggle"> <img decoding="async" src="/wp-content/uploads/2024/10/plus.svg"> <strong>NMS-293</strong> <br>(PARP1) </a> </div> </td> <td class="indication"> <picture decoding="async" style="height: 14px;display: none;"> <source type="image/webp" srcset="/wp-content/uploads/2024/10/11127HIGH_MERCKLOGOBLUERGB-PROIMG.png.webp"/> <img decoding="async" src="/wp-content/uploads/2024/10/11127HIGH_MERCKLOGOBLUERGB-PROIMG.png"/> </picture> <br><span class="logo-label" style="display: none;">Collaboration / Option to License</span></td> <td class="preclinical smaller dash-right solid-left"> <div class="arrow shrank -grad" style="width: calc(100% + 280% - 25px);top: -30px;"><span class="text">BRCA Mutated Solid Tumors</span></div> <div class="arrow shrank -grad" style="width: calc(100% + 280% - 25px);top: 30px;"><span class="text">Glioblastoma Combo + TMZ</span></div> </td> <td class="phase-1 smaller no-left dash-right"></td> <td class="phase-2 smaller no-left dash-right"></td> <td class="phase-3 smaller dash-right"></td> <td class="phase-3 smaller no-left"></td> </tr> <tr class="target-info"><td colspan="7" style="color: #000; display: none;" > <p>NMS-293 is a potent, highly selective PARP1 inhibitor designed to avoid trapping, a known cause of toxicity in healthy cells, making it ideal for combination with DNA-damaging agents like chemotherapies or ADC payloads. Combination dosing is the key for the PARP field to move beyond BRCA mutations. NMS-293 is currently in a Phase 2 study of patients with relapsed glioblastoma, IDH wild type, in combination with temozolomide. Initial safety data across the program showed high bone marrow tolerability (Guerts et al, AACR-NCI-EORTC 2023), paving the way for future combinations in other tumors. </p> <div class="elementor-widget-container"> <div class="elementor-button-wrapper"> <a class="elementor-button elementor-button-link elementor-size-sm" href="#NMS-293"> <span class="elementor-button-content-wrapper"> <span class="elementor-button-icon" style="padding-top: 3px;"> <picture decoding="async" style="width: 25px;"> <source type="image/webp" srcset="/wp-content/uploads/2024/10/arrow-1.png.webp"/> <img decoding="async" src="/wp-content/uploads/2024/10/arrow-1.png"/> </picture> </span> <span class="elementor-button-text" style=" font-size: 1rem; color: #000; ">More Information</span> </span> </a> </div> </div> </td></tr> <tr class="data green-grad" id="pipeline_atamparib"> <td class="target"> <div class="table-label"> <a href="#" class="target-info-toggle"> <img decoding="async" src="/wp-content/uploads/2024/10/plus.svg"> <div style="width: 150%;"><strong>Atamparib</strong> <br>(PARP7)</div> </a> </div> </td> <td class="indication"></td> <td class="preclinical smaller dash-right solid-left"> <div class="arrow shrank -grad" style="width: calc(100% + 192% - 2px);"><span class="text"></span></div> </td> <td class="phase-1 smaller no-left dash-right"></td> <td class="phase-2 smaller no-left dash-right"></td> <td class="phase-3 smaller dash-right"></td> <td class="phase-3 smaller no-left"></td> </tr> </tr> <tr class="target-info"><td colspan="7" style="color: #000; display: none;" > <p>Atamparib is an orally bioavailable, selective small-molecule PARP7 inhibitor designed to inhibit tumor growth in specific cancer types. As a mono-ADP ribosylating enzyme, PARP7 plays a crucial role in controlling key oncogenic pathways that support cancer cell survival. With high selectivity and potency, Atamparib offers a promising approach for addressing high unmet needs in oncology, particularly where PARP7 is a critical factor in disease progression. Atamparib has demonstrated favorable safety across early trials and is poised for a Phase II clinical trial in 2025. </p> <div class="elementor-widget-container"> <div class="elementor-button-wrapper"> <a class="elementor-button elementor-button-link elementor-size-sm" href="#PARP7"> <span class="elementor-button-content-wrapper"> <span class="elementor-button-icon" style="padding-top: 3px;"> <picture decoding="async" style="width: 25px;"> <source type="image/webp" srcset="/wp-content/uploads/2024/10/arrow-1.png.webp"/> <img decoding="async" src="/wp-content/uploads/2024/10/arrow-1.png"/> </picture> </span> <span class="elementor-button-text" style="font-size: 1rem;color: #000;">More Information</span> </span> </a> </div> </div> </td></tr> <tr class="data green-grad" id="pipeline_PDC"> <td rowspan="6" style="vertical-align: middle;background-color: #BF0000!important;text-align: center;padding: 16px;border-top: 10px solid #d0cece;"> <div class="vertical-textADC"> <div class="content">ADC Platform</div> </div> </td> <td rowspan="6" style="vertical-align: middle;"> </td> <td class="target" style="vertical-align: middle;"> <div class="table-label"> <a href="#" class="target-info-toggle"> <img decoding="async" src="/wp-content/uploads/2024/10/plus.svg"> <div style="float: left;width: 70%;"><strong>Peptide Drug Conjugate (PDC)</strong></div> </a> </div> </td> <td class="indication"><img decoding="async" src="/wp-content/uploads/2024/10/ITALFARMACO-LOGO-HEX-RGB-comp304560.png" style="height: 40px;"> <br><span class="logo-label" style="margin-top: -4px;">Non-Exclusive</span></td> <td class="preclinical smaller dash-right solid-left"> <div class="arrow shrank -grad" style="width: calc(100% + 5% - 25px);font-size: .7rem;"><span class="text">Undisclosed</span></div> </td> <td class="phase-1 smaller no-left dash-right"></td> <td class="phase-2 smaller no-left dash-right"></td> <td class="phase-3 smaller dash-right"></td> <td class="phase-3 smaller no-left"></td> </tr> <tr class="target-info"><td colspan="7" style="color: #000; display: none;" > <p>Peptide-Drug Conjugates (PDCs) combine the core benefits of enhanced cellular permeability and improved drug selectivity, enabling targeted delivery to cancer cells. By leveraging the enhanced tumor penetration and tumor-specific binding properties of peptides, PDCs can reduce off-target toxicity and improve therapeutic outcomes. </p> </td></tr> <tr class="data green-grad" id="pipeline_ADC"> <td class="target"> <div class="table-label"> <a href="#" class="target-info-toggle"> <img decoding="async" src="/wp-content/uploads/2024/10/plus.svg"> <div style="float: left;width: 70%;"><strong>Antibody Drug Conjugate (ADC)</strong></div> </a> </div> </td> <td class="indication"><strong>Confidential</strong><br><span class="logo-label">Non-Exclusive</span></td> <td class="preclinical smaller dash-right solid-left"> <div class="arrow shrank -grad" style="width: calc(100% + 5% - 25px);font-size: .7rem;"><span class="text">Undisclosed</span></div> </td> <td class="phase-1 smaller no-left dash-right"></td> <td class="phase-2 smaller no-left dash-right"></td> <td class="phase-3 smaller dash-right"></td> <td class="phase-3 smaller no-left"></td> </tr> <tr class="target-info"><td colspan="7" style="color: #000; display: none;" > <p>Antibody-Drug Conjugates (ADCs) are engineered to deliver highly potent cytotoxic drugs directly to cancer cells via targeted antibodies. This selective approach enhances efficacy while minimizing damage to healthy tissue, making ADCs a powerful tool in precision oncology. </p> </td></tr> <tr class="data green-grad" id="pipeline_payload_linkers"> <td class="target"> <div class="table-label"> <a href="#" class="target-info-toggle"> <img decoding="async" src="/wp-content/uploads/2024/10/plus.svg"> <div style="float: left;width: 60%;"><strong>Platform of Payload Linkers</strong> <br>(Undisclosed)</div> </a> </div> </td> <td class="indication"></td> <td class="preclinical smaller dash-right solid-left"> <div class="arrow shrank -grad" style="width: calc(0% + 20% - 5px);"></div> </td> <td class="phase-1 smaller no-left dash-right"></td> <td class="phase-2 smaller no-left dash-right"></td> <td class="phase-3 smaller dash-right"></td> <td class="phase-3 smaller no-left"></td> </tr> <tr class="target-info"><td colspan="7" style="color: #000; display: none;" > <p>Payload linkers are key components of ADCs and PDCs. Selection of the most appropriate payload-linkers, based also on the biology of the target, is essential to ensure the precise release of the drug inside the target cells, optimization of the therapeutic effect and reduced toxicity </p> </td></tr> </tbody> </table> </div> <br> <div class="legend-container"><span class="circle"></span>Approved/Launched</div><div class="pipeline-logo"><img decoding="async" src="/wp-content/uploads/2024/10/nerviano-logo.png" style="width: 160px;"></div> </div> </section> <style> .section__bg__wrap.padded .inner-container, section.padded .inner-container { padding: 40px 0; } .pipeline-section .inner-container { max-width: 1170px; } .inner-container { margin: auto; width: 100%; max-width: 1410px; } .center { text-align: center!important; } .white, .white p, .white h2, .white h3 { color: #FFF!important; } table tbody>tr:nth-child(odd)>td, table tbody>tr:nth-child(odd)>th { background-color: unset!important; } .pipeline-wrap { overflow-x: auto; } .pipeline-section .inner-container { max-width: 1170px } table.pipeline td { /*border:2px solid #d6dbe0;*/ padding: 10px 0px; 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right: -30px; z-index: -1; } /*table.pipeline tr.green-grad td .arrow:after { background: #F8382D; } */ table.pipeline tr.target-info td { display: none; } @media only screen and (max-width: 665px) { .pipeline-wrap { margin: 0 -20px; } .target-info-toggle img { float: none; margin: 0 auto 8px; } table.pipeline tr td.indication { min-width: 253px; } table.pipeline .preclinical, table.pipeline .phase-1, table.pipeline .phase-2, table.pipeline .phase-3 { min-width: 118px; } } @media only screen and (min-width: 666px) and (max-width: 1376px) { table.pipeline .preclinical, table.pipeline .phase-1, table.pipeline .phase-2, table.pipeline .phase-3 { min-width:97px; } } @media only screen and (min-width: 666px) and (max-width: 1275px) { table.pipeline:not(.waypointed) tr:not(.pipeline-header) td .arrow span.text { font-size: .7rem; } } </style> </div> </div> <div class="elementor-element elementor-element-54ef414 print-yes elementor-hidden-widescreen elementor-hidden-desktop elementor-hidden-laptop elementor-hidden-tablet elementor-hidden-mobile elementor-widget elementor-widget-image" data-id="54ef414" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <picture decoding="async" class="attachment-full size-full wp-image-4714"> <source type="image/webp" srcset="https://www.nervianoms.com/wp-content/uploads/2024/11/nervianoms-pipeline-print.png.webp 1200w, https://www.nervianoms.com/wp-content/uploads/2024/11/nervianoms-pipeline-print-148x300.png.webp 148w, https://www.nervianoms.com/wp-content/uploads/2024/11/nervianoms-pipeline-print-504x1024.png.webp 504w, https://www.nervianoms.com/wp-content/uploads/2024/11/nervianoms-pipeline-print-768x1560.png.webp 768w, https://www.nervianoms.com/wp-content/uploads/2024/11/nervianoms-pipeline-print-756x1536.png.webp 756w, https://www.nervianoms.com/wp-content/uploads/2024/11/nervianoms-pipeline-print-1008x2048.png.webp 1008w" sizes="(max-width: 1200px) 100vw, 1200px"/> <img decoding="async" width="1200" height="2437" src="https://www.nervianoms.com/wp-content/uploads/2024/11/nervianoms-pipeline-print.png" alt="" srcset="https://www.nervianoms.com/wp-content/uploads/2024/11/nervianoms-pipeline-print.png 1200w, https://www.nervianoms.com/wp-content/uploads/2024/11/nervianoms-pipeline-print-148x300.png 148w, https://www.nervianoms.com/wp-content/uploads/2024/11/nervianoms-pipeline-print-504x1024.png 504w, https://www.nervianoms.com/wp-content/uploads/2024/11/nervianoms-pipeline-print-768x1560.png 768w, https://www.nervianoms.com/wp-content/uploads/2024/11/nervianoms-pipeline-print-756x1536.png 756w, https://www.nervianoms.com/wp-content/uploads/2024/11/nervianoms-pipeline-print-1008x2048.png 1008w" sizes="(max-width: 1200px) 100vw, 1200px"/> </picture> </div> </div> </div> </div> <div class="elementor-element elementor-element-ee62f7b cells-left e-flex e-con-boxed e-con e-parent" data-id="ee62f7b" data-element_type="container" data-settings="{"background_background":"classic"}"> <div class="e-con-inner"> <div class="elementor-element elementor-element-7180b9b elementor-widget elementor-widget-heading" data-id="7180b9b" data-element_type="widget" id="encorafenib" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Encorafenib (BRAF) </h2> </div> </div> <div class="elementor-element elementor-element-1b3e076 elementor-widget elementor-widget-text-editor" data-id="1b3e076" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Encorafenib is a small molecule inhibitor of the BRAF kinase, a key enzyme in the tyrosine kinase/MAPK signaling pathway (TK-RAS-RAF-MEK-ERK), which is often mutated and activated in different tumors, such as melanoma, colorectal cancer, non-small cell lung cancer and others. Encorafenib is a potent BRAF inhibitor for which NMS has licensed enabling IP rights for commercialization. BRAFTOVI® (the brand name for encorafenib) is approved in combination with the MEK inhibitor binimetinib (MEKTOVI®) for the treatment of unresectable or metastatic melanoma with a BRAFV600E or BRAFV600K mutation. It is also the first BRAF inhibitor approved in combination with cetuximab (Erbitux®) for the treatment of adult patients with metastatic colorectal cancer (CRC) with a BRAF V600E mutation. More recently, the FDA and EMA have approved BRAFTOVI® + MEKTOVI® for the treatment of adult patients with metastatic non-small cell lung cancer (NSCLC) with a BRAF V600E mutation. A royalty agreement with Blue Owl Capital has been announced in September 2024. <a href="https://www.nmsgroup.it/wp-content/uploads/2024/09/20240814-Braftovi-BO-Divestment-vBO-Approved-2.pdf" target="_blank" rel="noopener">Press release</a></p> </div> </div> </div> </div> <div class="elementor-element elementor-element-ebcd6f8 e-flex e-con-boxed e-con e-parent" data-id="ebcd6f8" data-element_type="container" id="entrectinib" data-settings="{"background_background":"classic"}"> <div class="e-con-inner"> <div class="elementor-element elementor-element-7fb06a0 elementor-widget elementor-widget-heading" data-id="7fb06a0" data-element_type="widget" id="entrectinib" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Entrectinib (TRK, ROS) </h2> </div> </div> <div class="elementor-element elementor-element-708c7cb elementor-widget elementor-widget-text-editor" data-id="708c7cb" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Entrectinib is a selective inhibitor of the tyrosine kinases TRK A/B/C, ROS1 and ALK, whose activating gene rearrangements drive proliferation in small subsets of different tumor types. Entrectinib was invented and developed into Phase I by NMS, then licensed to Ignyta (San Diego, USA), a company subsequently acquired by Roche. Entrectinib is one of the first drugs approved with an agnostic indication for adult and pediatric patients with relapsed/refractory tumors harboring NTRK gene fusions, independently from the tumor type. It is also approved for the treatment of adults with ROS1-positive, metastatic non-small cell lung cancer (NSCLC). Entrectinib has been specifically designed to efficiently penetrate the blood brain barrier and it is efficacious also in patients with brain metastases, with a good tolerability profile.</p> </div> </div> </div> </div> <div class="elementor-element elementor-element-1869b27 cells-right e-flex e-con-boxed e-con e-parent" data-id="1869b27" data-element_type="container" data-settings="{"background_background":"classic"}"> <div class="e-con-inner"> <div class="elementor-element elementor-element-db60046 elementor-widget elementor-widget-heading" data-id="db60046" data-element_type="widget" id="onvansertib" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Onvansertib (PLK1) </h2> </div> </div> <div class="elementor-element elementor-element-056b172 elementor-widget elementor-widget-text-editor" data-id="056b172" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Onvansertib is the first orally available, potent and selective inhibitor of the PLK1 kinase, a master regulator of mitotic progression which is overexpressed and activated in proliferating cancer cells. The drug was invented and developed into Phase I by NMS, then licensed to the US Biotech Trovagene/Cardiff Oncology. Clinical development is currently ongoing with promising results in Phase I/II studies in combination, including a Phase Ib/II study with FOLFIRI/bevacizumab for treatment of metastatic KRAS mut CRC. For a comprehensive, up-to-date, Onvansertib overview please refer to the <a href="https://cardiffoncology.com/onvansertib/" target="_blank" rel="noopener">Cardiff Oncology website</a>.</p> </div> </div> </div> </div> <div class="elementor-element elementor-element-02f6dea cells-right e-flex e-con-boxed e-con e-parent" data-id="02f6dea" data-element_type="container" data-settings="{"background_background":"classic"}"> <div class="e-con-inner"> <div class="elementor-element elementor-element-48693d2 elementor-widget__width-inherit elementor-widget elementor-widget-heading" data-id="48693d2" data-element_type="widget" id="NMS-153" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">NMS-153 (MPS1)</h2> </div> </div> <div class="elementor-element elementor-element-3d2d61e e-con-full e-flex e-con e-child" data-id="3d2d61e" data-element_type="container"> <div class="elementor-element elementor-element-a4af0d2 elementor-widget elementor-widget-text-editor" data-id="a4af0d2" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p> </p><p>NMS-153 is a potent and highly selective small molecule inhibitor of Monopolar Spindle 1 (MPS1, also known as TTK kinase) with differentiated, dual anti-cancer mechanism of action. MPS1 is found to be highly expressed in a number of human tumors that play a critical role in the control of mitosis. The mechanism of action of NMS-153 relies upon targeting mitotic cancer cells, causing premature entry into anaphase, before chromosomes are properly aligned at the metaphase plate. This leads to mitotic catastrophe and apoptosis while potentially also harnessing a patient’s immune system by activation of the cGAS/STING pathway and inducing immunogenic cell death.</p><p>NMS-153 is a molecule with long residence time on the target and selective against a wide range of tested enzymes. In vitro, a brief exposure to the compound is sufficient to commit cancer cells to death. Its anti-proliferative activity is associated with a demonstrated mechanism of action in different tumor cell lines, including hepatocellular carcinoma and broad in vivo efficacy both as single agent and in combination with standards of care. NMS-153 is currently in Phase I/II clinical development in hepatocellular carcinoma as single agent (<a href="https://clinicaltrials.gov/study/NCT05630937" target="_blank" rel="noopener">NCT05630937</a>) Combination studies are planned.</p> </div> </div> </div> </div> </div> <div class="elementor-element elementor-element-bdbabde e-flex e-con-boxed e-con e-parent" data-id="bdbabde" data-element_type="container" id="nms-812" data-settings="{"background_background":"classic"}"> <div class="e-con-inner"> <div class="elementor-element elementor-element-9067f8e elementor-widget__width-inherit elementor-widget elementor-widget-heading" data-id="9067f8e" data-element_type="widget" id="NMS-812" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">NMS-812 (PERK/GCN2) </h2> </div> </div> <div class="elementor-element elementor-element-dcfbdde e-con-full e-flex e-con e-child" data-id="dcfbdde" data-element_type="container"> <div class="elementor-element elementor-element-c1d0503 elementor-widget elementor-widget-text-editor" data-id="c1d0503" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>NMS-812 is a novel, potent and orally bioavailable dual inhibitor of PERK (PKR-like endoplasmic reticulum kinase) and GCN2 (General Control Nonderepressible 2), with potential for first-in-class in several potential oncology indications. PERK and GCN2 are effectors of the Integrated Stress Response (ISR), a pro-survival pathway exploited by cancer cells to survive stress. The modulation of ISR may potentially overcome drug resistance and offer superior anti-tumoral activity. In addition, NMS-812 also modulates the immune response via direct and indirect mechanisms which may contribute to anti-cancer activity. The first-in-human (FIH) study showed an excellent pharmacokinetic profile allowing daily oral dosing and likely permissive safety for further development. Based on preclinical data and its unique, dual targeting of the two key components of the Integrated Stress Response PERK and GCN2, NMS-812 may represent a novel strategy for Acute Myeloid Leukemia (AML), with potential for synergies with other drugs and overcoming drug resistance.</p> </div> </div> </div> <div class="elementor-element elementor-element-6d8c806 e-con-full e-flex e-con e-child" data-id="6d8c806" data-element_type="container"> <div class="elementor-element elementor-element-e0888ab elementor-align-left elementor-mobile-align-left more-btn elementor-widget elementor-widget-button" data-id="e0888ab" data-element_type="widget" data-widget_type="button.default"> <div class="elementor-widget-container"> <div class="elementor-button-wrapper"> <a class="elementor-button elementor-button-link elementor-size-sm" href="https://nervianoms.com/our-science/"> <span class="elementor-button-content-wrapper"> <span class="elementor-button-icon"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 68 68" width="68" height="68"><defs><clipPath id="cp1"><path d="m-240-1988h1920v6578h-1920z"></path></clipPath><linearGradient id="P" gradientUnits="userSpaceOnUse"></linearGradient><linearGradient id="g1" x2="1" href="#P" gradientTransform="matrix(64.077,41.5,-41.5,64.077,3.923,8.604)"><stop stop-color="#f75225"></stop><stop offset="1" stop-color="#f00"></stop></linearGradient></defs><style>.a{fill:url(#g1)}.b{fill:#fff}</style><g clip-path="url(#cp1)"><path class="a" d="m34 68c-18.8 0-34-15.2-34-34 0-18.8 15.2-34 34-34 18.8 0 34 15.2 34 34 0 18.8-15.2 34-34 34z"></path><path class="b" d="m26.3 19.8c-0.9 0-1.8 0.3-2.4 1-0.6 0.7-0.9 1.7-0.7 2.6 0.3 1.5 1.6 2.7 3.2 2.6h11.2l-16.5 16.5c-1.3 1.1-1.4 3.1-0.3 4.4 0.6 0.7 1.4 1.1 2.4 1.1 0.8 0 1.6-0.4 2.1-1l16.7-16.6v11.1c-0.1 1.6 1 3 2.6 3.3 0.9 0.2 1.8-0.1 2.5-0.7 0.7-0.6 1.1-1.5 1.1-2.4v-18.8c0-1.7-1.4-3.1-3.1-3.1z"></path></g></svg> </span> <span class="elementor-button-text">Learn more about our programs </span> </span> </a> </div> </div> </div> </div> </div> </div> <div class="elementor-element elementor-element-6fb3ea0 cells-left cells-left2 e-flex e-con-boxed e-con e-parent" data-id="6fb3ea0" data-element_type="container" data-settings="{"background_background":"classic"}"> <div class="e-con-inner"> <div class="elementor-element elementor-element-82519a5 elementor-widget elementor-widget-heading" data-id="82519a5" data-element_type="widget" id="NMS-293" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">NMS-293 (PARP1)</h2> </div> </div> <div class="elementor-element elementor-element-0aa632f elementor-widget elementor-widget-image" data-id="0aa632f" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <picture decoding="async" class="attachment-full size-full wp-image-3278"> <source type="image/webp" srcset="https://www.nervianoms.com/wp-content/uploads/2024/10/PARP1-Inhibitor.png.webp 1176w, https://www.nervianoms.com/wp-content/uploads/2024/10/PARP1-Inhibitor-300x117.png.webp 300w, https://www.nervianoms.com/wp-content/uploads/2024/10/PARP1-Inhibitor-1024x401.png.webp 1024w, https://www.nervianoms.com/wp-content/uploads/2024/10/PARP1-Inhibitor-768x300.png.webp 768w" sizes="(max-width: 1176px) 100vw, 1176px"/> <img decoding="async" width="1176" height="460" src="https://www.nervianoms.com/wp-content/uploads/2024/10/PARP1-Inhibitor.png" alt="NMS-293 - clinical stage inhibitor" srcset="https://www.nervianoms.com/wp-content/uploads/2024/10/PARP1-Inhibitor.png 1176w, https://www.nervianoms.com/wp-content/uploads/2024/10/PARP1-Inhibitor-300x117.png 300w, https://www.nervianoms.com/wp-content/uploads/2024/10/PARP1-Inhibitor-1024x401.png 1024w, https://www.nervianoms.com/wp-content/uploads/2024/10/PARP1-Inhibitor-768x300.png 768w" sizes="(max-width: 1176px) 100vw, 1176px"/> </picture> </div> </div> <div class="elementor-element elementor-element-0c0e3a5 elementor-widget elementor-widget-text-editor" data-id="0c0e3a5" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>NMS-293 is a unique, intrinsically targeted PARP1 inhibitor. It is the only clinical stage inhibitor that is PARP1-selective with high potency and non-trapping. Recent, emerging, second generation PARP1-selective inhibitors may have similar bone marrow effects relative to marketed PARP1/2 inhibitors; for example: 11% grade 3 neutropenia at the relevant dose of saruparib (<a href="https://www.aacr.org/about-the-aacr/newsroom/news-releases/next-generation-parp-inhibitor-demonstrates-clinical-benefit-in-patients-with-homologous-recombination-repair-deficient-breast-cancer/" target="_blank" rel="noopener">Yap et al AACR 2024</a>) being similar to 9-10% for olaparib (<a href="https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/208558s028lbl.pdf" target="_blank" rel="noopener">Lynparza USPI</a>)</p><p>Since trapping is known to cause toxicity in healthy cells (<a href="https://aacrjournals.org/mcr/article/17/2/409/90064/PARP1-Trapping-by-PARP-Inhibitors-Drives" target="_blank" rel="noopener">Hopkins et al MCR 2019, Morice et al Lancet Hem 2021</a>), it is possible that trapping PARP inhibitors will continue to have difficulty combining with DNA-damaging drugs or chemotherapies, as has been the case historically. This limitation of combinations will likely hinder development of trapping PARP inhibitors in therapies beyond BRCA mutations or other types of homologous recombination deficiency, including chemotherapies and ADC payloads. In this way, many avenues of therapies and tumors have potential for NMS-293 beyond BRCA mutation tumors.</p><p>NMS-293 is brain-penetrant, adding value to its non-trapping, PARP1-selective features since it has potential for brain tumors or tumors bearing brain metastases. NMS-293 is currently enrolling in a study of high-grade gliomas and IDH wild type GBM (glioblastoma) co-dosing with temozolomide. Safety findings were presented in 2023 (<a href="https://aacrjournals.org/mct/article/22/12_Supplement/LB_A12/730469/Abstract-LB-A12-Initial-results-from-2-Phase-I" target="_blank" rel="noopener">Guerts et al, AACR-NCI-EORTC 2023</a>) NMS-293 has completed Phase 1 in a multi-tumor monotherapy study for dose finding (PARPA-293-001, <a href="https://clinicaltrials.gov/study/NCT04182516" target="_blank" rel="noopener">NCT04182516</a> as well as the Phase 1 part of the temozolomide co-dose glioma and GBM study (PARPA-293-002, <a href="https://clinicaltrials.gov/study/NCT04910022" target="_blank" rel="noopener">NCT04910022</a>), which is now enrolling in Phase 2 expansion.</p> </div> </div> </div> </div> <div class="elementor-element elementor-element-31af151 cells-right e-flex e-con-boxed e-con e-parent" data-id="31af151" data-element_type="container" id="PARP7" data-settings="{"background_background":"classic"}"> <div class="e-con-inner"> <div class="elementor-element elementor-element-9b52d72 elementor-widget__width-inherit elementor-widget elementor-widget-heading" data-id="9b52d72" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">Atamparib (PARP7)</h2> </div> </div> <div class="elementor-element elementor-element-06f90f5 e-con-full e-flex e-con e-child" data-id="06f90f5" data-element_type="container"> <div class="elementor-element elementor-element-4bcb77a elementor-widget elementor-widget-text-editor" data-id="4bcb77a" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Atamparib is the first-ever developed PARP7 inhibitor. The PARP7 enzyme, a key member of the PARP family, plays a critical role in oncology by being upregulated in response to cellular stress and regulating key oncogenic proteins that promote cancer cell survival through its mono-ADP ribosylation activity. By targeting and inhibiting this activity, atamparib effectively inhibits tumor growth in specific cancer types. This compound is highly potent against PARP7, with a long-lasting target binding and exceptional selectivity over other PARP family members. As an orally bioavailable small molecule, atamparib is the first therapeutic agent targeting PARP7 to advance into clinical trials. It has demonstrated an excellent clinical safety profile (<a href="https://clinicaltrials.gov/study/NCT04053673" target="_blank" rel="noopener"><u data-renderer-mark="true">NCT04053673</u></a>, <a href="https://clinicaltrials.gov/study/NCT05127590?tab=results" target="_blank" rel="noopener"><u data-renderer-mark="true">NCT05127590</u></a>, <a href="https://rctportal.niph.go.jp/en/detail?trial_id=jRCT2031210373" target="_blank" rel="noopener"><u data-renderer-mark="true">JRCT2031210373</u></a>) and shows promising therapeutic potential both as a monotherapy and in combination with other treatments for select indications.</p> </div> </div> </div> </div> </div> </div> </div> </main> <div data-elementor-type="footer" data-elementor-id="216" class="elementor elementor-216 elementor-location-footer" data-elementor-post-type="elementor_library"> <div class="elementor-element elementor-element-cc49d6a e-flex e-con-boxed e-con e-parent" data-id="cc49d6a" data-element_type="container" 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