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20 Years Ago This Month: Human Genome Project Sequences 92% of the Human Genome
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It was one that had major implications for the future of DNA sequencing and healthcare at large. </div> </div> <div class="header-graphic flex-1"> <img src="https://oxfordglobal.com/hubfs/Website/Images/Resources/Omics/20-Years-Ago-This-Month-Human-Genome-Project-Sequences-92-of-the-Human-Genome-.jpg" class="header-graphic-image"> </div> </div> </div> </div> <div class="container-wrapper"> <div class="wide-container"> <div class="content"> <div class="content-body text-gap"> <!-- wp:paragraph --> <p>In April 2003, the Human Genome Project produced a sequence that accounted for over 90% of the human genome. </p> <!-- /wp:paragraph --> <!-- wp:paragraph --> <p>The project was established in 1990 with the aim of mapping out the base pairs constituting human DNA, comprehensively mapping out a complete genome. </p> <!-- /wp:paragraph --> <!-- wp:paragraph --> <p>As a collaborative international effort, the Human Genome Project was the product of a desire to explore an unknown part of the biological world. </p> <!-- /wp:paragraph --> <!-- wp:paragraph --> <p>It involved researchers from 20 different academic institutions and research centres across the world, including the UK, US, France, Germany, Japan, and China. </p> <!-- /wp:paragraph --> <!-- wp:paragraph --> <p>Economic gains and benefits from the approaches pioneered have reflected direct links between resulting products and advances in the pharmaceutical and biotechnological industries. </p> <!-- /wp:paragraph --> <!-- wp:paragraph --> <p>Because the project aimed to sequence the complete human genome, significant effort was made to improve contemporary methods for DNA sequencing. </p> <!-- /wp:paragraph --> <!-- wp:paragraph --> <p>The project ultimately used one particular method for DNA sequencing — Sanger sequencing — but helped to advance the basic method through a series of major technical innovations, laying the groundwork for the future introduction of next generation sequencing methods. </p> <!-- /wp:paragraph --> <!-- wp:heading --> <h2 id="h-the-legacy-of-the-human-genome-project">The Legacy of the Human Genome Project</h2> <!-- /wp:heading --> <!-- wp:paragraph --> <p>In 2003, researchers involved in the project announced that it had generated an ‘essentially complete’ human genome sequence, with 92% of the human genome accounted for.</p> <!-- /wp:paragraph --> <!-- wp:paragraph --> <p>However a truly complete sequence was only achieved by the Telomere-to-Telomere (T2T) consortium in 2022. </p> <!-- /wp:paragraph --> <!-- wp:paragraph --> <p>Still, this was the best that could be achieved with technology available at the time, and it represented a landmark in collaborative approaches to scientific research. </p> <!-- /wp:paragraph --> <!-- wp:paragraph --> <p>Further accomplishments associated with the sequencing of the human genome included an advanced draft of the mouse genome sequence, as well as an initial draft of the rat genome.</p> <!-- /wp:paragraph --> <!-- wp:list --> <ul><!-- wp:list-item --> <li><a href="https://oxfordglobal.com/resources/untargeted-metabolomics-data-analysis-reinforced-by-ai-ml-techniques/" target="_blank" rel="noreferrer noopener">How untargeted metabolomics analysis is being reinforced by AI/ML approaches</a></li> <!-- /wp:list-item --> <!-- wp:list-item --> <li><a href="https://oxfordglobal.com/resources/spatial-analysis-of-tme-microglia-in-melanoma-brain-metastasis/" target="_blank" rel="noreferrer noopener">Treating the untreatable with new approaches to melanoma brain metastases</a></li> <!-- /wp:list-item --> <!-- wp:list-item --> <li><a href="https://oxfordglobal.com/resources/antibody-mediated-rejection-and-next-gen-sequencing-in-precision-medicine/" target="_blank" rel="noreferrer noopener">Improving patient success in the fight against graft versus host disease</a> </li> <!-- /wp:list-item --></ul> <!-- /wp:list --> <!-- wp:paragraph --> <p></p> <!-- /wp:paragraph --> <!-- wp:paragraph --> <p>In addition, the project identified more than three million human genetic variations known as single-cell nucleotide polymorphisms (SNPs).</p> <!-- /wp:paragraph --> <!-- wp:paragraph --> <p>Every part of the draft human genome sequence was made publicly available shortly after production, in line with the ‘Bermuda Principles’ agreed upon in development. </p> <!-- /wp:paragraph --> <!-- wp:paragraph --> <p>This agreement has been credited with establishing a greater awareness and openness to the sharing of data in biomedical research. </p> <!-- /wp:paragraph --> <!-- wp:paragraph --> <p><em>Get your weekly dose of industry news and announcements </em><a href="https://oxfordglobal.com/omics/news/" target="_blank" rel="noreferrer noopener"><em>here</em></a><em>, or head over to our </em><a href="https://oxfordglobal.com/omics/" target="_blank" rel="noreferrer noopener"><em>Omics portal</em></a><em> to catch up with the latest advances in spatial analysis and next-gen sequencing.</em></p> <!-- 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Used in combination with data from the 100,000 Genome Project, these techniques could reduce the time taken for patients to receive a diagnosis for rare genetic diseases. </div> <div class="read-more"> <a href="/precision-medicine/resources/de-novo-variants-genomic-sequencing-and-problem-solving-for-future-treatments" class="read-more-link">Read More</a> </div></a> </div> </div> <div class="article"> <a href="/precision-medicine/resources/towards-a-single-cell-atlas-of-the-mouse-brain-using-an-automated-spatial-omics-platform"> <div class="cover-graphic"> <img src="https://oxfordglobal.com/hubfs/Website/Images/Resources/Omics/Towards-a-Single-Cell-Atlas-of-the-Mouse-Brain-Using-an-Automated-Spatial-Omics-Platform.jpg" class="cover-graphic-image"> </div> </a><div class="content"><a href="/precision-medicine/resources/towards-a-single-cell-atlas-of-the-mouse-brain-using-an-automated-spatial-omics-platform"> <h4> Towards a Single-Cell Atlas of the Mouse Brain Using an Automated Spatial Omics Platform </h4> <div class="abstract"> </div> <div class="read-more"> <a href="/precision-medicine/resources/towards-a-single-cell-atlas-of-the-mouse-brain-using-an-automated-spatial-omics-platform" class="read-more-link">Read More</a> </div></a> </div> </div> </div> </div> </div> </div> </div> </div> <div class="newsletter-cta"> <h2 class="heading">Subscribe to our newsletter</h2> <div class="message"> Sign up for our monthly Newsletter to keep up with all things Precision Medicine </div> <div class="button-wrapper"> <a href="#" class="button hs-cta-trigger-button hs-cta-trigger-button-177053686110">Newsletter Sign-Up</a> </div> </div> </main> <div data-global-resource-path="git/og-stage/templates/partials/footer.html"><footer class="website-footer flex flex-column g-20"> <div class="footer-columns"> <div class="footer-column"> <a href="https://oxfordglobal.com" class="site-logo-link"> <img src="https://oxfordglobal.com/wp-content/uploads/2023/03/Oxford-Global-Logo-Stacked-Websize.png" class="site-logo"> </a> </div> <div class="footer-column"> <h3>Brands</h3> <ul> <li> <a href="/precision-medicine/">Precision Medicine</a> </li> <li> <a href="/discovery-development/">Discovery & Development</a> </li> <li> <a href="/nextgen-biomed/">NextGen Biomed</a> </li> </ul> </div> <div class="footer-column"> <h3>Services</h3> <ul> <li> <a href="https://oxfordglobal.com/in-person-services/"> In-Person Services </a> </li> <li> <a href="https://oxfordglobal.com/digital-marketing-services/"> Digital Marketing Services </a> </li> </ul> <h3>Upcoming Events</h3> <ul> <li> <a href="https://oxfordglobal.com/calendar/"> Event Calendar </a> </li> </ul> </div> <div class="footer-column"> <h3>Company</h3> <ul> <li class="elementor-icon-list-item"> <a href="https://oxfordglobal.com/about-us/"> About </a> </li> <li class="elementor-icon-list-item"> <a href="https://oxfordglobal.com/vacancies/"> Vacancies </a> </li> <li class="elementor-icon-list-item"> <a href="https://oxfordglobal.com/csr-policy/"> CSR Policy </a> </li> <li class="elementor-icon-list-item"> <a href="javascript:postMessage({type:'HS_DISPLAY_CALL_TO_ACTION',id:130207947529});"> Contact </a> </li> </ul> </div> <div class="footer-column"> <p> <a href="tel:+441865248455">+44 1865 248 455</a><br> <a href="mailto:help@oxfordglobal.com">help@oxfordglobal.com</a> </p> <p> <strong>Our UK Address:</strong><br> Godstow Court<br> Minns Business Park<br> Botley<br> Oxford, OX2 0JB </p> <p> <strong>Our US Address:</strong><br> 100 Cambridge Street<br> 14th Floor<br> Boston<br> MA 02114 </p> </div> </div> <div class="footer-bottom grid g-20"> <div class="span8 span12-sm span12-md flex flex-column g-10"> <div class="copyright"> © Oxford Global Marketing Ltd. 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