Actinium-225 | NorthStar Medical Radioisotopes, LLC

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class="section-content "> <section class="h2_header_short"> <div class="container"> <div class="header-inner"> <a href="https://www.northstarnm.com/therapeutics/" class="h2_breadcrumb_link mb-2 md-blue">Radiopharmaceutical Therapy</a> <h1 class="mb-5"><span>Actinium-225</span></h1> <div class="h2_intro_box"> <p>Actinium-225 (Ac-225) is considered one of the rarest radioisotopes on earth. It is not naturally occurring and therefore needs to be manufactured. There are several technologies used to produce Ac-225 but none that can scale to meet commercial quantities. NorthStar’s method is capable of meeting customer demand.</p> </div> </div> <div class="header-img"> <img src="https://www.northstarnm.com/wp-content/uploads/2023/02/header-actinium.png" alt="" class="img-fluid w-100" /> </div> </div> </section> <section class="r7_row_multicolumns py-normal-t " > <div class="container"> <div class="row"> <div class="col-12 relative d-flex flex-column "> <div class="row align-items-start "> <div class="col-12 mx-auto"> <div class="video-box"> <a class="modaltrigger1" data-target="#videomodal"><img src="https://www.northstarnm.com/wp-content/uploads/2023/08/still-actinium-video.jpg" class="w-100 img-fluid mb-5 mb-lg-0" alt="" /></a> <div class="modalhidden" style="display: none;"> <div class="video-container"> <div style="position:relative;padding-bottom:56.25%;overflow:hidden;height:0;max-width:100%;"><iframe id="70eb3bee-a6f6-4745-9cd6-9d82e1136331" src="https://iframe.dacast.com/vod/aaf2a0fa4f6098082a74d1683a18ff38/70eb3bee-a6f6-4745-9cd6-9d82e1136331" width="100%" height="100%" frameborder="0" scrolling="no" allow="autoplay;encrypted-media" allowfullscreen webkitallowfullscreen mozallowfullscreen oallowfullscreen msallowfullscreen style="position:absolute;top:0;left:0;"></iframe></div> </div> </div> </div> </div> </div> </div> </div> </div> </section> <section class="r7_row_multicolumns py-normal-b " > <div class="container"> <div class="row"> <div class="col-12 relative d-flex flex-column "> <div class="p-5 bg-white-fade mt-5"> <div class="row align-items-start "> <div class="col-md-5 "> <h2 class="title mb-4 md-blue"> PRODUCING SUFFICIENT SUPPLY<br><span>TO MEET GLOBAL DEMAND</span> </h2>  </div> <div class="col-md-7 "> <div class="copy mb-4 mb-md-0"> <p>NorthStar is pioneering groundbreaking technology to produce commercial quantities of actinium-225 from radium-226 targets using electron beam accelerators. The process begins with the acceleration of an electron that collides with a converter. The converter absorbs the energy from the electrons, converting it into a high-energy photon that collides with the target material, removing a neutron from the nucleus of the atoms resulting in radium-225.</p> <p>Next, a chemical purification process is completed removing all actinium, including actinium-227, leaving a purified radium solution. The purified radium solution is allowed to decay and produce non-carrier added (n.c.a.) Ac-225. This process substantially increases production capacity and flexibility due to multiple radium solutions being on-line simultaneously.</p> </div>  </div> <div class="col-md-5 "> <div class="featured-img"> <img src="https://www.northstarnm.com/wp-content/uploads/2023/02/reduce.svg" class="w-75 img-fluid mb-4" alt="" /> </div> <div class="copy mb-4 mb-md-0"> <p>Radium solution used will be reclaimed and used again as future target material.</p> <div class="actinium-download"> <div class="mt-5 row align-items-center"> <div class="col-3"><a href="https://www.northstarnm.com/wp-content/uploads/2024/05/Actinium-Sheet-April-2024.pdf" target="_blank" rel="noopener"><img decoding="async" class="w-100 img-fluid" src="https://www.northstarnm.com/wp-content/uploads/2023/02/icon-pdf-b-2.svg" alt="" /></a></div> <div class="col-9"> <div class="download_title md-blue">View</div> <div class="download_desc_lg md-blue">Our Actinium-225<br /> Fact Sheet</div> </div> </div> </div> </div>  </div> <div class="col-md-7 text-center"> <div class="featured-img"> <img src="https://www.northstarnm.com/wp-content/uploads/2023/02/Ac-Process-med-01.png" class="w-100 img-fluid mb-4" alt="" /> </div> <div class="lead mb-5"> <p><a class="download_desc_lg md-blue" href="#noncarrier" rel="noopener">LEARN MORE ABOUT NON-CARRIER ADDED Ac-225</a></p> </div>  </div> </div> </div> </div> </div> </div> </section> </div> </section> <section class="section-bg bg-white" > <div class="section-content "> <div class="r15_whitepaper bg-white py-60"> <div class="container px-md-5"> <div class="row align-items-center"> <div class="col-md-6"> <div class="wp-title"> <h2 class="mb-4">Discover<br><strong>more</strong></h2> </div> <div class="wp-intro mb-2"> <p>We examine the various methods of producing Actinium-225 in our latest White Paper.</p> </div> <div class="wp-link"> <a href="https://www.northstarnm.com/wp-content/uploads/2023/11/Accelerating-Production-of-Non-Carrier-Added-Actinium-225-n.c.a.-Ac-225.pdf" class="library-link" target="_blank">Read Now</a> </div> </div> <div class="col-md-3 offset-md-2"> <div class="wp-thumbnail"> <a href="https://www.northstarnm.com/wp-content/uploads/2023/11/Accelerating-Production-of-Non-Carrier-Added-Actinium-225-n.c.a.-Ac-225.pdf" target="_blank"> <img src="https://www.northstarnm.com/wp-content/uploads/2023/10/tn-whitepaper.webp" class="w-100 img-fluid" alt="" role="presentation" /> </a> </div> </div> </div> </div> </div> </div> </section> <section class="section-bg " style="background-color: #213083"> <div class="section-content "> <section class="r7_row_multicolumns " > <div class="container"> <div class="row"> <div class="col-12 relative d-flex flex-column "> <div class="row py-normal align-items-center "> <div class="col-md-5 "> <div class="featured-img"> <img src="https://www.northstarnm.com/wp-content/uploads/2023/10/Be4-acc-Oct-2023-01.png" class=" w-75 img-fluid mb-5 mb-lg-0" alt="" /> </div> </div> <div class="col-md-7 white"> <h2 class="title mb-4 white"> THE RHODOTRON<sup>®</sup> TT-300 HE (HIGH ENERGY)<br><span>ELECTRON BEAM ACCELERATOR </span> </h2> <div class="copy mb-4 mb-md-0"> <p>NorthStar is using an electron accelerator, a first-in-kind technology, to produce n.c.a. Ac-225. High energy electron accelerators provide several advantages over other production methods. Accelerators have a relatively small footprint and are designed to operate for extended periods of time. They have the ability to produce commercial scale quantities of radioisotopes while using less power and starting material, without creating long lived byproducts. Choosing this technology is consistent with NorthStar鈥檚 commitment to greening healthcare.</p> <p>NorthStar鈥檚 third electron accelerator, dedicated exclusively to the production of n.c.a. Ac-225, was delivered and installed in early 2023.</p> </div>  </div> </div> <div class="row py-normal align-items-center bg-green-building mb-3"> <div class="col-12 building-img"> <div class="featured-img"> <img src="https://www.northstarnm.com/wp-content/uploads/2024/02/facility-actinium.jpg" class="mb-0 w-100 img-fluid mb-5 mb-lg-0" alt="" /> </div> </div> <div class="col-12 px-4 px-md-5 pt-md-5 pb-4"> <h2 class="title mb-4 "> BUILDING A HOME FOR GLOBAL Ac-225 PRODUCTION </h2> <div class="lead mb-5"> <p>In September 2021, NorthStar held a groundbreaking ceremony on a 30,000 square foot facility dedicated to the production of commercial-scale n.c.a Ac-225 produced with a dedicated IBA Rhodotron<sup>庐</sup> TT300-HE electron accelerator, delivered and installed in early 2023. The buildout of both internal and external infrastructure is nearly complete. The state-of-the-art radiochemistry lab is complete, and validations of redundant analytical equipment are underway.聽 The Rhodotron power supply, beamline, and target rooms are advancing as planned and the one-of-a-kind hot cell train footprint is in place. NorthStar expects initial radiochemical grade (RCG) production of n.c.a. Ac-225 in 2025 and filing of the drug master file for cGMP n.c.a. Ac-225 production in 2025. These timelines are dependent on supply chain execution from our various global vendors. NorthStar has a dedicated team working daily to maintain the timelines in an effort to have the greatest impact on patients.</p> </div>  </div> <div class="col-12 "> <div class="module-timeline px-5"> <div class="row"> <div class="col-md-3"> <h2 class="title mb-4 text-white">TIMELINE</h2> </div> <div class="col-md-9"> <div class="timeline-container theme-white-green-blue"> <div class="timeline-item status-complete"> <div class="timeline-date"> Sept 2021 </div> <div class="timeline-status"> <div class="timeline-status-inner"> <i class="fa-sharp fa-solid fa-check"></i> </div> </div> <div class="timeline-content"> Facility Groundbreaking </div> </div> <div class="timeline-item status-complete"> <div class="timeline-date"> Nov 2021 </div> <div class="timeline-status"> <div class="timeline-status-inner"> <i class="fa-sharp fa-solid fa-check"></i> </div> </div> <div class="timeline-content"> Orders placed for accelerators and essential long-lead items </div> </div> <div class="timeline-item status-complete"> <div class="timeline-date"> Early 2022 </div> <div class="timeline-status"> <div class="timeline-status-inner"> <i class="fa-sharp fa-solid fa-check"></i> </div> </div> <div class="timeline-content"> Construction begins </div> </div> <div class="timeline-item "> <div class="timeline-date"> Q1 2025 </div> <div class="timeline-status"> <div class="timeline-status-inner"> </div> </div> <div class="timeline-content"> Initial production of radiochemical grade Ac-225 </div> </div> <div class="timeline-item "> <div class="timeline-date"> LATE 2025 </div> <div class="timeline-status"> <div class="timeline-status-inner"> </div> </div> <div class="timeline-content"> Drug Master File Submitted to FDA </div> </div> </div> </div> </div> </div> </div> </div> <div class="row align-items-start mb-3 text-center bg-white p-5"> <div class="col-12 md-blue"> <h2 class="title mb-4 "> Publicly announced<br><span>supply agreements</span> </h2> <div class="copy mb-4 mb-md-0"> <div class="row my-5 text-center"> <div class="col-6 col-md-4 mx-auto mb-3"><a href="https://www.northstarnm.com/northstar-medical-radioisotopes-and-point-biopharma-announce-supply-agreement-for-therapeutic-medical-radioisotope-actinium-225/" target="_blank" rel="noopener"><img decoding="async" class="w-75 img-fluid alignnone" src="https://www.northstarnm.com/wp-content/uploads/2023/02/logo-point-pharm.png" alt="" width="250" height="125" /></a></div> <div class="col-6 col-md-4 mx-auto mb-3"><a href="https://www.northstarnm.com/northstar-medical-radioisotopes-and-convergent-therapeutics-announce-supply-agreement-for-therapeutic-radioisotope-actinium-225-ac-225/" target="_blank" rel="noopener"><img decoding="async" class="w-75 img-fluid alignnone" src="https://www.northstarnm.com/wp-content/uploads/2023/02/logo-convergent.png" alt="" width="250" height="125" /></a></div> <div class="col-6 col-md-4 mx-auto mb-3"><a href="https://www.northstarnm.com/northstar-medical-radioisotopes-announces-supply-agreement-with-aktis-oncology-inc-for-alpha-emitting-therapeutic-radioisotope-actinium-225-ac-225/" target="_blank" rel="noopener"><img decoding="async" class="w-75 img-fluid alignnone" src="https://www.northstarnm.com/wp-content/uploads/2023/02/logo-aktis.png" alt="" width="250" height="125" /></a></div> <div class="col-6 col-md-4 mx-auto mb-3"><a href="https://www.northstarnm.com/northstar-medical-radioisotopes-and-curie-therapeutics-announce-priority-access-supply-agreement-for-therapeutic-radioisotope-actinium-225-ac-225/" target="_blank" rel="noopener"><img decoding="async" class="w-75 img-fluid alignnone" src="https://www.northstarnm.com/wp-content/uploads/2023/03/logo-mariana.png" alt="" width="250" height="125" /></a></div> <div class="col-6 col-md-4 mx-auto mb-3"><a href="https://www.northstarnm.com/radiopharm-theranostics-signs-agreement-with-northstar-medical-radioisotopes-for-the-supply-of-non-carrier-added-n-c-a-actinium-225/" target="_blank" rel="noopener"><img decoding="async" class="w-75 img-fluid alignnone" src="https://www.northstarnm.com/wp-content/uploads/2023/02/logo-rad.png" alt="" width="250" height="125" /></a></div> <div class="col-6 col-md-4 mx-auto mb-3"><a href="https://www.northstarnm.com/northstar-medical-radioisotopes-announces-supply-agreement-with-nucleus-radiopharma-for-alpha-emitting-therapeutic-radioisotope-actinium-225-ac-225/" target="_blank" rel="noopener"><img decoding="async" class="w-75 img-fluid alignnone" src="https://www.northstarnm.com/wp-content/uploads/2023/07/logo-nucleus.png" alt="" width="250" height="125" /></a></div> <div class="col-6 col-md-4 mx-auto mb-3"><a href="https://www.northstarnm.com/northstar-medical-radioisotopes-executes-supply-agreement-with-bayer-for-therapeutic-radioisotope-actinium%E2%80%90225-ac%E2%80%90225/" target="_blank" rel="noopener"><img decoding="async" class="w-75 img-fluid alignnone" src="https://www.northstarnm.com/wp-content/uploads/2023/08/logo-bayer-1.png" alt="" width="250" height="125" /></a></div> <div class="col-6 col-md-4 mx-auto mb-3"><a href="https://www.northstarnm.com/northstar-medical-radioisotopes-and-curadh-mtr-announce-a-strategic-long-term-supply-agreement-for-therapeutic-radioisotope-actinium-225/" target="_blank" rel="noopener"><img decoding="async" class="w-75 img-fluid alignnone" src="https://www.northstarnm.com/wp-content/uploads/2023/09/logo-curadh-color.png" alt="" width="250" height="125" /></a></div> <div class="col-6 col-md-4 mx-auto mb-3"><a href="https://www.northstarnm.com/northstar-medical-radioisotopes-and-alpha-9-oncology-enter-strategic-long-term-agreement-for-supply-of-actinium-225-ac-225/" target="_blank" rel="noopener"><img decoding="async" class="w-75 img-fluid alignnone" src="https://www.northstarnm.com/wp-content/uploads/2024/01/logo-alpha9.png" alt="" width="250" height="125" /></a></div> <div class="col-6 col-md-4 mx-auto mb-3"><a href="https://www.northstarnm.com/northstar-bwxt-medical-sign-supply-agreement/" target="_blank" rel="noopener"><img decoding="async" src="https://www.northstarnm.com/wp-content/uploads/2024/06/logo-monopar-1.png" /></a></div> <div class="col-6 col-md-4 mx-auto mb-3"><a href="https://www.northstarnm.com/northstar-medical-radioisotopes-executes-supply-agreement-with-cellectar-biosciences-for-therapeutic-radioisotope-actinium-225-ac-225/" target="_blank" rel="noopener"><img decoding="async" src="https://www.northstarnm.com/wp-content/uploads/2024/11/cellectar.svg" /></a></div> <div class="col-12 mt-4 black text-center"><em>Multiple other supply agreements have been executed but not made public at this time</em></div> </div> </div>  </div> </div> </div> </div> </div> </section> <section class="r6_tile_block_h eco-row"> <div class="r6_tile_block_h_inner mx-4 mx-md-0"> <div class="container bg-bright-blue px-0"> <div class="row"> <div class="col-md-6 m-0 p-0 r6-col r6-col-img"> <img src="https://www.northstarnm.com/wp-content/uploads/2023/02/eco.jpg" alt="" class="img-fluid w-100" /> </div> <div class="col-md-6 m-0 p-0 r6-col d-flex"> <div class="px-4 my-4 my-md-0 align-self-center"> <h2 class="title mb-4 white"> <span id="noncarrier"></span>What is <span class="text-transform-none">NON-CARRIER ADDED (n.c.a.)?</span> </h2> <div class="copy"> <p>Sometimes, inactive materials are added to a radioactive substance to ensure that its radioactivity will behave normally in future chemical and physical processes. NorthStar鈥檚 Ac-225 is non-carrier added (n.c.a.), meaning no stable elements have been added in our process of producing or isolating Ac-225. Our production processes prevent the disposal and strictly regulated storage of long-lived Ac-227, which help to keep our Earth a little greener.</p> </div> </div> </div> </div> </div> </div> </section> </div> </section> </div> <footer class="py-5"> <div class="container"> <div class="row"> <div class="col-12 col-md-4 mb-4 mb-md-0 py-md-2"> <p class="footer-brand"><img src="https://www.northstarnm.com/wp-content/themes/northstar/img/logo-w.svg" alt="NorthStar Medical Radioisotopes, LLC" class="w-100 img-fluid" /></p> <div class="contact-box"> <p>1800 Gateway Boulevard<br /> Beloit, WI 53511<br /> <strong>Phone:</strong> <a href="tel:8444386659">(844) 438-6659</a><br /> <strong>Phone:</strong> <a href="tel:6083138000">(608) 313-8000</a></p> </div> </div> <div class="col-md-4 py-md-2 mb-4 mb-md-0"> <div class="menu-main-menu-container"><ul id="menu-main-menu-2" class="menu" itemscope itemtype="http://www.schema.org/SiteNavigationElement"><li class="menu-item menu-item-type-post_type menu-item-object-page current-page-ancestor current-menu-ancestor current-menu-parent current-page-parent current_page_parent current_page_ancestor menu-item-12125"><a href="https://www.northstarnm.com/radiopharmaceutical-therapy/">Radiopharmaceutical Therapy</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-12604"><a href="https://www.northstarnm.com/cdmo-cmo/">CDMO/CMO</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-10982"><a href="https://www.northstarnm.com/development/">Development</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-10981"><a href="https://www.northstarnm.com/company/">Company</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-10980"><a href="https://www.northstarnm.com/careers/">Careers</a></li> <li class="searchlink menu-item menu-item-type-custom menu-item-object-custom menu-item-10984"><a href="#search"><i class="fas fa-search"></i> <span class="navhide">Search</span></a></li> </ul></div> </div> <div class="col-12 col-md-4 mb-4 mb-md-0 border-left px-md-4 py-md-2"> <div class="f-col-title"> HOW CAN WE HELP? </div> <div class="f-col-content"> <p>Questions about our company, products, supply solutions, careers or anything else?</p> </div> <div class="f-col-link"> <a href="https://www.northstarnm.com/company/contact-us/" target="" class="btn btn-wire">Contact Us</a> </div> <div class="inline-links"> <ul class="social-links"> <li><a href="https://www.linkedin.com/company/northstar-medical-radioisotopes-llc/" target="_blank" title=""><span class="social-text">LinkedIn</span><span class="fa-stack" style="vertical-align: top;"> <i class="fas fa-circle fa-stack-2x"></i> <i class="fab fa-linkedin-in fa-stack-1x fa-inverse"></i> </span></a></li> <li><a href="https://www.instagram.com/northstarmedicalradioisotopes/" target="_blank" title=""><span class="social-text">Instagram</span><span class="fa-stack" style="vertical-align: top;"> <i class="fas fa-circle fa-stack-2x"></i> <i class="fab fa-instagram fa-stack-1x fa-inverse"></i> </span></a></li> </ul> </div> </div> <div class="col-12 footer-copyright py-3 mb-5 white"> 漏<script>var CurrentYear = new Date().getFullYear(); document.write(CurrentYear);</script> NMR. 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Actinium-225 | NorthStar Medical Radioisotopes, LLC