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class="vector-toc-numb">2</span> <span>Classification</span> </div> </a> <ul id="toc-Classification-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Membrane-associated_lyases" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Membrane-associated_lyases"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Membrane-associated lyases</span> </div> </a> <ul id="toc-Membrane-associated_lyases-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-See_also" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#See_also"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>See also</span> </div> </a> <ul id="toc-See_also-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>References</span> </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span 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Available in 32 languages" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-32" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">32 languages</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D9%84%D9%8A%D8%A7%D8%B2" title="لياز – Arabic" lang="ar" hreflang="ar" data-title="لياز" data-language-autonym="العربية" data-language-local-name="Arabic" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-bg mw-list-item"><a href="https://bg.wikipedia.org/wiki/%D0%9B%D0%B8%D0%B0%D0%B7%D0%B0" title="Лиаза – Bulgarian" lang="bg" hreflang="bg" data-title="Лиаза" data-language-autonym="Български" data-language-local-name="Bulgarian" class="interlanguage-link-target"><span>Български</span></a></li><li class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/Lijaza" title="Lijaza – Bosnian" lang="bs" hreflang="bs" data-title="Lijaza" data-language-autonym="Bosanski" data-language-local-name="Bosnian" class="interlanguage-link-target"><span>Bosanski</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Liasa" title="Liasa – Catalan" lang="ca" hreflang="ca" data-title="Liasa" data-language-autonym="Català" data-language-local-name="Catalan" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Ly%C3%A1za" title="Lyáza – Czech" lang="cs" hreflang="cs" data-title="Lyáza" data-language-autonym="Čeština" data-language-local-name="Czech" class="interlanguage-link-target"><span>Čeština</span></a></li><li class="interlanguage-link interwiki-da mw-list-item"><a href="https://da.wikipedia.org/wiki/Lyase" title="Lyase – Danish" lang="da" hreflang="da" data-title="Lyase" data-language-autonym="Dansk" data-language-local-name="Danish" class="interlanguage-link-target"><span>Dansk</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Lyasen" title="Lyasen – German" lang="de" hreflang="de" data-title="Lyasen" data-language-autonym="Deutsch" data-language-local-name="German" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Liasa" title="Liasa – Spanish" lang="es" hreflang="es" data-title="Liasa" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D9%84%DB%8C%D8%A7%D8%B2" title="لیاز – Persian" lang="fa" hreflang="fa" data-title="لیاز" data-language-autonym="فارسی" data-language-local-name="Persian" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Lyase" title="Lyase – French" lang="fr" hreflang="fr" data-title="Lyase" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Liase" title="Liase – Galician" lang="gl" hreflang="gl" data-title="Liase" data-language-autonym="Galego" data-language-local-name="Galician" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EB%B6%84%ED%95%B4_%ED%9A%A8%EC%86%8C" title="분해 효소 – Korean" lang="ko" hreflang="ko" data-title="분해 효소" data-language-autonym="한국어" data-language-local-name="Korean" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-hy mw-list-item"><a href="https://hy.wikipedia.org/wiki/%D4%BC%D5%AB%D5%A1%D5%A6%D5%B6%D5%A5%D6%80" title="Լիազներ – Armenian" lang="hy" hreflang="hy" data-title="Լիազներ" data-language-autonym="Հայերեն" data-language-local-name="Armenian" class="interlanguage-link-target"><span>Հայերեն</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Liasi" title="Liasi – Italian" lang="it" hreflang="it" data-title="Liasi" data-language-autonym="Italiano" data-language-local-name="Italian" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-lt mw-list-item"><a href="https://lt.wikipedia.org/wiki/Liaz%C4%97s" title="Liazės – Lithuanian" lang="lt" hreflang="lt" data-title="Liazės" data-language-autonym="Lietuvių" data-language-local-name="Lithuanian" class="interlanguage-link-target"><span>Lietuvių</span></a></li><li class="interlanguage-link interwiki-ms mw-list-item"><a href="https://ms.wikipedia.org/wiki/Liase" title="Liase – Malay" lang="ms" hreflang="ms" data-title="Liase" data-language-autonym="Bahasa Melayu" data-language-local-name="Malay" class="interlanguage-link-target"><span>Bahasa Melayu</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Lyase" title="Lyase – Dutch" lang="nl" hreflang="nl" data-title="Lyase" data-language-autonym="Nederlands" data-language-local-name="Dutch" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%83%AA%E3%82%A2%E3%83%BC%E3%82%BC" title="リアーゼ – Japanese" lang="ja" hreflang="ja" data-title="リアーゼ" data-language-autonym="日本語" data-language-local-name="Japanese" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-nn mw-list-item"><a href="https://nn.wikipedia.org/wiki/Lyase" title="Lyase – Norwegian Nynorsk" lang="nn" hreflang="nn" data-title="Lyase" data-language-autonym="Norsk nynorsk" data-language-local-name="Norwegian Nynorsk" class="interlanguage-link-target"><span>Norsk nynorsk</span></a></li><li class="interlanguage-link interwiki-uz mw-list-item"><a href="https://uz.wikipedia.org/wiki/Liazalar" title="Liazalar – Uzbek" lang="uz" hreflang="uz" data-title="Liazalar" data-language-autonym="Oʻzbekcha / ўзбекча" data-language-local-name="Uzbek" class="interlanguage-link-target"><span>Oʻzbekcha / ўзбекча</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Liazy" title="Liazy – Polish" lang="pl" hreflang="pl" data-title="Liazy" data-language-autonym="Polski" data-language-local-name="Polish" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Liase" title="Liase – Portuguese" lang="pt" hreflang="pt" data-title="Liase" data-language-autonym="Português" data-language-local-name="Portuguese" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Liaz%C4%83" title="Liază – Romanian" lang="ro" hreflang="ro" data-title="Liază" data-language-autonym="Română" data-language-local-name="Romanian" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%9B%D0%B8%D0%B0%D0%B7%D1%8B" title="Лиазы – Russian" lang="ru" hreflang="ru" data-title="Лиазы" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sk mw-list-item"><a href="https://sk.wikipedia.org/wiki/Ly%C3%A1za" title="Lyáza – Slovak" lang="sk" hreflang="sk" data-title="Lyáza" data-language-autonym="Slovenčina" data-language-local-name="Slovak" class="interlanguage-link-target"><span>Slovenčina</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Lijaza" title="Lijaza – Serbian" lang="sr" hreflang="sr" data-title="Lijaza" data-language-autonym="Српски / srpski" data-language-local-name="Serbian" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Lijaza" title="Lijaza – Serbo-Croatian" lang="sh" hreflang="sh" data-title="Lijaza" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="Serbo-Croatian" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Lyaasit" title="Lyaasit – Finnish" lang="fi" hreflang="fi" data-title="Lyaasit" data-language-autonym="Suomi" data-language-local-name="Finnish" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Lyaser" title="Lyaser – Swedish" lang="sv" hreflang="sv" data-title="Lyaser" data-language-autonym="Svenska" data-language-local-name="Swedish" class="interlanguage-link-target"><span>Svenska</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Liyaz" title="Liyaz – Turkish" lang="tr" hreflang="tr" data-title="Liyaz" data-language-autonym="Türkçe" data-language-local-name="Turkish" class="interlanguage-link-target"><span>Türkçe</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%9B%D1%96%D0%B0%D0%B7%D0%B8" title="Ліази – Ukrainian" lang="uk" hreflang="uk" data-title="Ліази" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E8%A3%82%E5%90%88%E9%85%B6" title="裂合酶 – Chinese" lang="zh" hreflang="zh" data-title="裂合酶" data-language-autonym="中文" data-language-local-name="Chinese" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a 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title="Structured data on this page hosted by Wikidata [g]" accesskey="g"><span>Wikidata item</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> </div> </div> </div> <div class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="Page tools"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Appearance"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Appearance</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">hide</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Class of enzyme which catalyzes elimination reactions</div> <style data-mw-deduplicate="TemplateStyles:r1236090951">.mw-parser-output .hatnote{font-style:italic}.mw-parser-output div.hatnote{padding-left:1.6em;margin-bottom:0.5em}.mw-parser-output .hatnote i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable">This article is about the group of enzymes. For the language, see <a href="/wiki/Lyase_language" class="mw-redirect" title="Lyase language">Lyase language</a>.</div> <p>In <a href="/wiki/Biochemistry" title="Biochemistry">biochemistry</a>, a <b>lyase</b> is an <a href="/wiki/Enzyme" title="Enzyme">enzyme</a> that catalyzes the <a href="/wiki/Bond_cleavage" title="Bond cleavage">breaking</a> (an <a href="/wiki/Elimination_reaction" title="Elimination reaction">elimination reaction</a>) of various <a href="/wiki/Chemical_bond" title="Chemical bond">chemical bonds</a> by means other than <a href="/wiki/Hydrolysis" title="Hydrolysis">hydrolysis</a> (a <a href="/wiki/Substitution_reaction" title="Substitution reaction">substitution reaction</a>) and <a href="/wiki/Oxidation" class="mw-redirect" title="Oxidation">oxidation</a>, often forming a new <a href="/wiki/Double_bond" title="Double bond">double bond</a> or a new <a href="/wiki/Ring_(chemistry)" title="Ring (chemistry)">ring structure</a>.<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> The reverse reaction is also possible (called a <a href="/wiki/Michael_reaction" class="mw-redirect" title="Michael reaction">Michael reaction</a>). For example, an enzyme that catalyzed this reaction would be a lyase: </p> <dl><dd><a href="/wiki/Adenosine_triphosphate" title="Adenosine triphosphate">ATP</a> → <a href="/wiki/Cyclic_adenosine_monophosphate" title="Cyclic adenosine monophosphate">cAMP</a> + PP<sub>i</sub></dd></dl> <p>Lyases differ from other enzymes in that they require only one <a href="/wiki/Substrate_(chemistry)" title="Substrate (chemistry)">substrate</a> for the reaction in one direction, but two substrates for the reverse reaction. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Nomenclature">Nomenclature</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Lyase&action=edit&section=1" title="Edit section: Nomenclature"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Systematic names are formed as "<i>substrate group-lyase</i>." Common names include <a href="/wiki/Decarboxylase" class="mw-redirect" title="Decarboxylase">decarboxylase</a>, <a href="/wiki/Dehydratase" title="Dehydratase">dehydratase</a>, <a href="/wiki/Aldolase" class="mw-redirect" title="Aldolase">aldolase</a>, etc. When the product is more important, <a href="/wiki/Synthase" title="Synthase">synthase</a> may be used in the name, e.g. phosphosulfolactate synthase (EC 4.4.1.19, Michael addition of sulfite to phosphoenolpyruvate). A combination of both an elimination and a Michael addition is seen in O-succinylhomoserine (thiol)-lyase (MetY or MetZ) which catalyses first the γ-elimination of O-succinylhomoserine (with succinate as a leaving group) and then the addition of sulfide to the vinyl intermediate, this reaction was first classified as a lyase (EC 4.2.99.9), but was then reclassified as a transferase (EC 2.5.1.48). </p> <div class="mw-heading mw-heading2"><h2 id="Classification">Classification</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Lyase&action=edit&section=2" title="Edit section: Classification"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Lyases are classified as EC 4 in the <a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC number</a> classification of enzymes. Lyases can be further classified into seven subclasses: </p> <ul><li><a href="/wiki/Category:EC_4.1" title="Category:EC 4.1">EC 4.1</a> includes lyases that cleave carbon–carbon bonds, such as <a href="/wiki/Decarboxylase" class="mw-redirect" title="Decarboxylase">decarboxylases</a> (EC 4.1.1), <a href="/wiki/Aldehyde_lyases" class="mw-redirect" title="Aldehyde lyases">aldehyde lyases</a> (EC 4.1.2), oxo acid lyases (EC 4.1.3), and others (EC 4.1.99)</li> <li><a href="/wiki/Category:EC_4.2" title="Category:EC 4.2">EC 4.2</a> includes lyases that cleave carbon–oxygen bonds, such as <a href="/wiki/Dehydratase" title="Dehydratase">dehydratases</a></li> <li><a href="/wiki/Category:EC_4.3" title="Category:EC 4.3">EC 4.3</a> includes lyases that cleave carbon–nitrogen bonds</li> <li><a href="/wiki/Category:EC_4.4" title="Category:EC 4.4">EC 4.4</a> includes lyases that cleave carbon–sulfur bonds</li> <li><a href="/wiki/Category:EC_4.5" title="Category:EC 4.5">EC 4.5</a> includes lyases that cleave carbon–halide bonds</li> <li><a href="/wiki/Category:EC_4.6" title="Category:EC 4.6">EC 4.6</a> includes lyases that cleave phosphorus–oxygen bonds, such as <a href="/wiki/Adenylyl_cyclase" title="Adenylyl cyclase">adenylyl cyclase</a> and <a href="/wiki/Guanylyl_cyclase" class="mw-redirect" title="Guanylyl cyclase">guanylyl cyclase</a></li> <li><a href="/wiki/Category:EC_4.99" title="Category:EC 4.99">EC 4.99</a> includes other lyases, such as <a href="/wiki/Ferrochelatase" title="Ferrochelatase">ferrochelatase</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="Membrane-associated_lyases">Membrane-associated lyases</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Lyase&action=edit&section=3" title="Edit section: Membrane-associated lyases"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Some lyases associate with <a href="/wiki/Biological_membranes" class="mw-redirect" title="Biological membranes">biological membranes</a> as <a href="/wiki/Peripheral_membrane_protein" title="Peripheral membrane protein">peripheral membrane proteins</a> or anchored through a single <a href="/wiki/Transmembrane_helix" class="mw-redirect" title="Transmembrane helix">transmembrane helix</a>.<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Lyase&action=edit&section=4" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/List_of_EC_numbers_(EC_4)" title="List of EC numbers (EC 4)">List of EC numbers of enzymes belonging to category EC 4</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Lyase&action=edit&section=5" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-1">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.uniprot.org/keywords/456">"Lyase"</a>. <i>www.uniprot.org</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=www.uniprot.org&rft.atitle=Lyase&rft_id=https%3A%2F%2Fwww.uniprot.org%2Fkeywords%2F456&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALyase" class="Z3988"></span></span> </li> <li id="cite_note-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-2">^</a></b></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://membranome.org/protein_classes/12">Superfamilies of single-pass transmembrane lyases</a> in <a href="/wiki/Membranome_database" title="Membranome database">Membranome database</a></span> </li> </ol></div></div> <ul><li><a rel="nofollow" class="external text" href="https://web.archive.org/web/20120716211104/http://www.chem.qmul.ac.uk/iubmb/enzyme/EC4/intro.html">EC 4 Introduction</a> from the Department of Chemistry at <a href="/wiki/Queen_Mary,_University_of_London" class="mw-redirect" title="Queen Mary, University of London">Queen Mary, University of London</a></li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output .hlist dl ol,.mw-parser-output .hlist dl ul,.mw-parser-output .hlist ol dl,.mw-parser-output .hlist ol ol,.mw-parser-output .hlist ol ul,.mw-parser-output .hlist ul dl,.mw-parser-output .hlist ul ol,.mw-parser-output .hlist ul ul{display:inline}.mw-parser-output .hlist .mw-empty-li{display:none}.mw-parser-output .hlist dt::after{content:": "}.mw-parser-output .hlist dd::after,.mw-parser-output .hlist li::after{content:" · ";font-weight:bold}.mw-parser-output .hlist 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style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Active_site" title="Active site">Active site</a></li> <li><a href="/wiki/Binding_site" title="Binding site">Binding site</a></li> <li><a href="/wiki/Catalytic_triad" title="Catalytic triad">Catalytic triad</a></li> <li><a href="/wiki/Oxyanion_hole" title="Oxyanion hole">Oxyanion hole</a></li> <li><a href="/wiki/Enzyme_promiscuity" title="Enzyme promiscuity">Enzyme promiscuity</a></li> <li><a href="/wiki/Diffusion-limited_enzyme" title="Diffusion-limited enzyme">Diffusion-limited enzyme</a></li> <li><a href="/wiki/Cofactor_(biochemistry)" title="Cofactor (biochemistry)">Cofactor</a></li> <li><a href="/wiki/Enzyme_catalysis" title="Enzyme catalysis">Enzyme catalysis</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Regulation</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a 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style="width:1%">Kinetics</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Enzyme_kinetics" title="Enzyme kinetics">Enzyme kinetics</a></li> <li><a href="/wiki/Eadie%E2%80%93Hofstee_diagram" title="Eadie–Hofstee diagram">Eadie–Hofstee diagram</a></li> <li><a href="/wiki/Hanes%E2%80%93Woolf_plot" title="Hanes–Woolf plot">Hanes–Woolf plot</a></li> <li><a href="/wiki/Lineweaver%E2%80%93Burk_plot" title="Lineweaver–Burk plot">Lineweaver–Burk plot</a></li> <li><a href="/wiki/Michaelis%E2%80%93Menten_kinetics" title="Michaelis–Menten kinetics">Michaelis–Menten kinetics</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Types</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><b>EC1 <a href="/wiki/Oxidoreductase" title="Oxidoreductase">Oxidoreductases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_1)" title="List of EC numbers (EC 1)">list</a>)</li> <li><b>EC2 <a href="/wiki/Transferase" title="Transferase">Transferases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_2)" title="List of EC numbers (EC 2)">list</a>)</li> <li><b>EC3 <a href="/wiki/Hydrolase" title="Hydrolase">Hydrolases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_3)" title="List of EC numbers (EC 3)">list</a>)</li> <li><b>EC4 <a class="mw-selflink selflink">Lyases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_4)" title="List of EC numbers (EC 4)">list</a>)</li> <li><b>EC5 <a href="/wiki/Isomerase" title="Isomerase">Isomerases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_5)" title="List of EC numbers (EC 5)">list</a>)</li> <li><b>EC6 <a href="/wiki/Ligase" title="Ligase">Ligases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_6)" title="List of EC numbers (EC 6)">list</a>)</li> <li><b>EC7 <a href="/wiki/Translocase" title="Translocase">Translocases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_7)" title="List of EC numbers (EC 7)">list</a>)</li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Carbon–carbon_lyases_(EC_4.1)" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Carbon%E2%80%93carbon_lyases" title="Template:Carbon–carbon lyases"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Carbon%E2%80%93carbon_lyases" title="Template talk:Carbon–carbon lyases"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Carbon%E2%80%93carbon_lyases" title="Special:EditPage/Template:Carbon–carbon lyases"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Carbon–carbon_lyases_(EC_4.1)" style="font-size:114%;margin:0 4em">Carbon–carbon <a class="mw-selflink selflink">lyases</a> (<a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC</a> 4.1)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_4)#EC_4.1.1:_Carboxy-Lyases" title="List of EC numbers (EC 4)">4.1.1</a>: <a href="/wiki/Carboxy-lyases" title="Carboxy-lyases">Carboxy-lyases</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Acetoacetate_decarboxylase" title="Acetoacetate decarboxylase">Acetoacetate decarboxylase</a></li> <li><a href="/wiki/Adenosylmethionine_decarboxylase" title="Adenosylmethionine decarboxylase">Adenosylmethionine decarboxylase</a></li> <li><a href="/wiki/Arginine_decarboxylase" title="Arginine decarboxylase">Arginine decarboxylase</a></li> <li><a href="/wiki/Aromatic_L-amino_acid_decarboxylase" title="Aromatic L-amino acid decarboxylase">Aromatic L-amino acid decarboxylase</a></li> <li><a href="/wiki/Glutamate_decarboxylase" title="Glutamate decarboxylase">Glutamate decarboxylase</a></li> <li><a href="/wiki/Histidine_decarboxylase" title="Histidine decarboxylase">Histidine decarboxylase</a></li> <li><a href="/wiki/Lysine_decarboxylase" title="Lysine decarboxylase">Lysine decarboxylase</a></li> <li><a href="/wiki/Malonyl-CoA_decarboxylase" title="Malonyl-CoA decarboxylase">Malonyl-CoA decarboxylase</a></li> <li><a href="/wiki/Ornithine_decarboxylase" title="Ornithine decarboxylase">Ornithine decarboxylase</a></li> <li><a href="/wiki/Oxaloacetate_decarboxylase" title="Oxaloacetate decarboxylase">Oxaloacetate decarboxylase</a></li> <li><a href="/wiki/Phosphoenolpyruvate_carboxykinase" title="Phosphoenolpyruvate carboxykinase">Phosphoenolpyruvate carboxykinase</a></li> <li><a href="/wiki/Phosphoenolpyruvate_carboxylase" title="Phosphoenolpyruvate carboxylase">Phosphoenolpyruvate carboxylase</a></li> <li><a href="/wiki/Phosphoribosylaminoimidazole_carboxylase" title="Phosphoribosylaminoimidazole carboxylase">Phosphoribosylaminoimidazole carboxylase</a></li> <li><a href="/wiki/Pyrophosphomevalonate_decarboxylase" class="mw-redirect" title="Pyrophosphomevalonate decarboxylase">Pyrophosphomevalonate decarboxylase</a></li> <li><a href="/wiki/Pyruvate_decarboxylase" title="Pyruvate decarboxylase">Pyruvate decarboxylase</a></li> <li><a href="/wiki/RuBisCO" title="RuBisCO">RuBisCO</a></li> <li><a href="/wiki/Uridine_monophosphate_synthetase" class="mw-redirect" title="Uridine monophosphate synthetase">Uridine monophosphate synthetase</a>/<a href="/wiki/Orotidine_5%27-phosphate_decarboxylase" title="Orotidine 5'-phosphate decarboxylase">Orotidine 5'-phosphate decarboxylase</a></li> <li><a href="/wiki/Uroporphyrinogen_III_decarboxylase" title="Uroporphyrinogen III decarboxylase">Uroporphyrinogen III decarboxylase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_4)#EC_4.1.2:_Aldehyde-Lyases" title="List of EC numbers (EC 4)">4.1.2</a>: <a href="/wiki/Aldehyde" title="Aldehyde">Aldehyde</a>-lyases</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Fructose-bisphosphate_aldolase" title="Fructose-bisphosphate aldolase">Fructose-bisphosphate aldolase</a> <ul><li><a href="/wiki/Aldolase_A" title="Aldolase A">Aldolase A</a></li> <li><a href="/wiki/Aldolase_B" title="Aldolase B">Aldolase B</a></li> <li><a href="/wiki/Aldolase_C" title="Aldolase C">Aldolase C</a></li></ul></li> <li><a href="/wiki/2-hydroxyphytanoyl-CoA_lyase" title="2-hydroxyphytanoyl-CoA lyase">2-hydroxyphytanoyl-CoA lyase</a></li> <li><a href="/wiki/Threonine_aldolase" title="Threonine aldolase">Threonine aldolase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_4)#EC_4.1.3:_Oxo-Acid-Lyases" title="List of EC numbers (EC 4)">4.1.3</a>: <a href="/wiki/Oxyacid" title="Oxyacid">Oxo-acid</a>-lyases</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Isocitrate_lyase" title="Isocitrate lyase">Isocitrate lyase</a></li> <li><a href="/wiki/3-hydroxy-3-methylglutaryl-CoA_lyase" class="mw-redirect" title="3-hydroxy-3-methylglutaryl-CoA lyase">3-hydroxy-3-methylglutaryl-CoA lyase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_4)#EC_4.1.99:_Other_Carbon-Carbon_Lyases" title="List of EC numbers (EC 4)">4.1.99</a>: Other</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Tryptophanase" title="Tryptophanase">Tryptophanase</a></li> <li><a href="/wiki/Photolyase" title="Photolyase">Photolyase</a> <ul><li><a href="/wiki/CPD_lyase" class="mw-redirect" title="CPD lyase">CPD lyase</a></li> <li><a href="/wiki/Spore_photoproduct_lyase" title="Spore photoproduct lyase">Spore photoproduct lyase</a></li></ul></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Carbon–oxygen_lyases_(EC_4.2)_(primarily_dehydratases)" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Carbon%E2%80%93oxygen_lyases" title="Template:Carbon–oxygen lyases"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Carbon%E2%80%93oxygen_lyases" title="Template talk:Carbon–oxygen lyases"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Carbon%E2%80%93oxygen_lyases" title="Special:EditPage/Template:Carbon–oxygen lyases"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Carbon–oxygen_lyases_(EC_4.2)_(primarily_dehydratases)" style="font-size:114%;margin:0 4em">Carbon–oxygen <a class="mw-selflink selflink">lyases</a> (<a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC</a> 4.2) (primarily <a href="/wiki/Dehydratase" title="Dehydratase">dehydratases</a>)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_4)#EC_4.2.1:_Hydro-Lyases" title="List of EC numbers (EC 4)">4.2.1</a>: <a href="/wiki/Hydro-lyase" title="Hydro-lyase">Hydro-Lyases</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Carbonic_anhydrase" title="Carbonic anhydrase">Carbonic anhydrase</a></li> <li><a href="/wiki/Fumarase" title="Fumarase">Fumarase</a></li> <li><a href="/wiki/Aconitase" title="Aconitase">Aconitase</a></li> <li><a href="/wiki/Enolase" title="Enolase">Enolase</a> <ul><li><a href="/wiki/Alpha-enolase" title="Alpha-enolase">Alpha</a></li> <li><a href="/wiki/Enolase_2" title="Enolase 2">Enolase 2</a></li></ul></li> <li><a href="/wiki/Enoyl-CoA_hydratase" title="Enoyl-CoA hydratase">Enoyl-CoA hydratase</a>/<a href="/wiki/3-Hydroxyacyl_ACP_dehydrase" title="3-Hydroxyacyl ACP dehydrase">3-Hydroxyacyl ACP dehydrase</a></li> <li><a href="/wiki/Methylglutaconyl-CoA_hydratase" title="Methylglutaconyl-CoA hydratase">Methylglutaconyl-CoA hydratase</a></li> <li><a href="/wiki/Tryptophan_synthase" title="Tryptophan synthase">Tryptophan synthase</a></li> <li><a href="/wiki/Cystathionine_beta_synthase" title="Cystathionine beta synthase">Cystathionine beta synthase</a></li> <li><a href="/wiki/Porphobilinogen_synthase" class="mw-redirect" title="Porphobilinogen synthase">Porphobilinogen synthase</a></li> <li><a href="/wiki/3-Isopropylmalate_dehydratase" title="3-Isopropylmalate dehydratase">3-Isopropylmalate dehydratase</a></li> <li><a href="/wiki/Urocanase" title="Urocanase">Urocanase</a></li> <li><a href="/wiki/Uroporphyrinogen_III_synthase" title="Uroporphyrinogen III synthase">Uroporphyrinogen III synthase</a></li> <li><a href="/wiki/Nitrile_hydratase" title="Nitrile hydratase">Nitrile hydratase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_4)#EC_4.2.2:_Acting_on_Polysaccharides" title="List of EC numbers (EC 4)">4.2.2</a>: Acting on polysaccharides</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Hyaluronate_lyase" title="Hyaluronate lyase">Hyaluronate lyase</a></li> <li><a href="/wiki/Pectin_lyase" title="Pectin lyase">Pectin lyase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_4)#EC_4.2.3:_Acting_on_phosphates" title="List of EC numbers (EC 4)">4.2.3</a>: Acting on phosphates</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Threonine_synthase" title="Threonine synthase">Threonine synthase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_4)#EC_4.2.99:_Other_Carbon-Oxygen_Lyases" title="List of EC numbers (EC 4)">4.2.99</a>: Other</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Carboxymethyloxysuccinate_lyase" title="Carboxymethyloxysuccinate lyase">Carboxymethyloxysuccinate lyase</a></li> <li><a href="/wiki/Hydroperoxide_lyase" title="Hydroperoxide lyase">Hydroperoxide lyase</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Carbon–nitrogen_lyases_(EC_4.3)" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Carbon%E2%80%93nitrogen_lyases" title="Template:Carbon–nitrogen lyases"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Carbon%E2%80%93nitrogen_lyases" title="Template talk:Carbon–nitrogen lyases"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Carbon%E2%80%93nitrogen_lyases" title="Special:EditPage/Template:Carbon–nitrogen lyases"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Carbon–nitrogen_lyases_(EC_4.3)" style="font-size:114%;margin:0 4em">Carbon–nitrogen <a class="mw-selflink selflink">lyases</a> (<a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC</a> 4.3)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_4)#EC_4.3.1:_Ammonia-Lyases" title="List of EC numbers (EC 4)">4.3.1</a>: ammonia-lyases</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Histidine_ammonia-lyase" title="Histidine ammonia-lyase">Histidine ammonia-lyase</a></li> <li><a href="/wiki/Formiminotransferase_cyclodeaminase" class="mw-redirect" title="Formiminotransferase cyclodeaminase">Formiminotransferase cyclodeaminase</a></li> <li><a href="/wiki/Serine_dehydratase" title="Serine dehydratase">Serine dehydratase</a></li> <li><a href="/wiki/Phenylalanine_ammonia-lyase" title="Phenylalanine ammonia-lyase">Phenylalanine ammonia-lyase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_4)#EC_4.3.2:_Amidine-Lyases" title="List of EC numbers (EC 4)">4.3.2</a>: amidine-lyases</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Argininosuccinate_lyase" title="Argininosuccinate lyase">Argininosuccinate lyase</a></li> <li><a href="/wiki/Adenylosuccinate_lyase" title="Adenylosuccinate lyase">Adenylosuccinate lyase</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Carbon–sulfur_lyases_(EC_4.4)" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Carbon%E2%80%93sulfur_lyases" title="Template:Carbon–sulfur lyases"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Carbon%E2%80%93sulfur_lyases" title="Template talk:Carbon–sulfur lyases"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Carbon%E2%80%93sulfur_lyases" title="Special:EditPage/Template:Carbon–sulfur lyases"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Carbon–sulfur_lyases_(EC_4.4)" style="font-size:114%;margin:0 4em">Carbon–sulfur <a class="mw-selflink selflink">lyases</a> (<a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC</a> 4.4)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_4)#EC_4.4:_Carbon-Sulfur_Lyases" title="List of EC numbers (EC 4)">4.4.1</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cystathionine_gamma-lyase" title="Cystathionine gamma-lyase">Cystathionine gamma-lyase</a></li> <li><a href="/wiki/Cystathionine_beta-lyase" title="Cystathionine beta-lyase">Cystathionine beta-lyase</a></li> <li><a href="/wiki/Leukotriene_C4_synthase" title="Leukotriene C4 synthase">Leukotriene C4 synthase</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Carbon–halide_lyases_(EC_4.5)" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Carbon%E2%80%93halide_lyases" title="Template:Carbon–halide lyases"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Carbon%E2%80%93halide_lyases" title="Template talk:Carbon–halide lyases"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Carbon%E2%80%93halide_lyases" title="Special:EditPage/Template:Carbon–halide lyases"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Carbon–halide_lyases_(EC_4.5)" style="font-size:114%;margin:0 4em">Carbon–halide <a class="mw-selflink selflink">lyases</a> (<a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC</a> 4.5)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_4)#EC_4.5:_Carbon-Halide_Lyases" title="List of EC numbers (EC 4)">4.5.1</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Dichloromethane_dehalogenase" title="Dichloromethane dehalogenase">Dichloromethane dehalogenase</a></li> <li><a href="/wiki/Halohydrin_dehalogenase" title="Halohydrin dehalogenase">Halohydrin dehalogenase</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Phosphorus–oxygen_lyases_(EC_4.6)" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Phosphorus%E2%80%93oxygen_lyases" title="Template:Phosphorus–oxygen lyases"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Phosphorus%E2%80%93oxygen_lyases" title="Template talk:Phosphorus–oxygen lyases"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Phosphorus%E2%80%93oxygen_lyases" title="Special:EditPage/Template:Phosphorus–oxygen lyases"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Phosphorus–oxygen_lyases_(EC_4.6)" style="font-size:114%;margin:0 4em">Phosphorus–oxygen <a class="mw-selflink selflink">lyases</a> (<a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC</a> 4.6)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_4)#EC_4.6:_Phosphorus-Oxygen_Lyases" title="List of EC numbers (EC 4)">4.6.1</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Adenylyl_cyclase" title="Adenylyl cyclase">Adenylate cyclase</a><br />(4.6.1.1)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">intracellular</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/ADCY1" title="ADCY1">ADCY1</a></li> <li><a href="/wiki/ADCY2" title="ADCY2">ADCY2</a></li> <li><a href="/wiki/ADCY3" title="ADCY3">ADCY3</a></li> <li><a href="/wiki/ADCY4" title="ADCY4">ADCY4</a></li> <li><a href="/wiki/ADCY5" title="ADCY5">ADCY5</a></li> <li><a href="/wiki/ADCY6" title="ADCY6">ADCY6</a></li> <li><a href="/wiki/ADCY7" title="ADCY7">ADCY7</a></li> <li><a href="/wiki/ADCY8" title="ADCY8">ADCY8</a></li> <li><a href="/wiki/ADCY9" title="ADCY9">ADCY9</a></li> <li><a href="/wiki/ADCY10" title="ADCY10">ADCY10</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">extracellular</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Extracellular_adenylate_cyclase" title="Extracellular adenylate cyclase">Extracellular adenylate cyclase</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Guanylate_cyclase" title="Guanylate cyclase">Guanylate cyclase</a><br />(4.6.1.2)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Soluble_guanylyl_cyclase" title="Soluble guanylyl cyclase">soluble guanylyl cyclase</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/GUCY1A2" title="GUCY1A2">GUCY1A2</a></li> <li><a href="/wiki/GUCY1A3" title="GUCY1A3">GUCY1A3</a></li> <li><a href="/w/index.php?title=GUCY1B2&action=edit&redlink=1" class="new" title="GUCY1B2 (page does not exist)">GUCY1B2</a></li> <li><a href="/wiki/GUCY1B3" title="GUCY1B3">GUCY1B3</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Guanylate_cyclase-coupled_receptor" title="Guanylate cyclase-coupled receptor">guanylate cyclase-coupled receptor</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Guanylate_cyclase_2C" title="Guanylate cyclase 2C">GUCY2C</a></li> <li><a href="/wiki/GUCY2D" title="GUCY2D">GUCY2D</a></li> <li><a href="/wiki/Atrial_natriuretic_peptide_receptor" title="Atrial natriuretic peptide receptor">ANP</a> (<a href="/wiki/NPR1" title="NPR1">NPR1</a></li> <li><a href="/wiki/NPR2" title="NPR2">NPR2</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cytidylate_cyclase" title="Cytidylate cyclase">Cytidylate cyclase</a></li> <li><a href="/wiki/2-C-methyl-D-erythritol_2,4-cyclodiphosphate_synthase" title="2-C-methyl-D-erythritol 2,4-cyclodiphosphate 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