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KEGG DRUG: Nateglinide
<!doctype html> <html><head> <title>KEGG DRUG: Nateglinide</title> <link type="text/css" rel="stylesheet" href="/css/gn2.css?1743938719"> <link type="text/css" rel="stylesheet" href="/css/bget.css?1743938719"> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <link type="text/css" rel="stylesheet" href="/css/bgetm.css?1743938719" media="only screen and (max-width: 768px)"> <style>.kcfd{display:none;}</style> <script> <!-- var getElementsByClassName = document.getElementsByClassName ? function (cl){ return document.getElementsByClassName(cl); } : function (cl){ var elms = []; var objs = document.getElementsByTagName('*'); for(var i=0;i<objs.length;i++){ var obj = objs[i]; if(obj.className == cl){ elms.push(obj); } } return elms; }; function toggleField(clk,cl,show,hide){ var objs = getElementsByClassName(cl); for(var i=0;i<objs.length;i++){ var obj = objs[i]; if(!obj.style.display||obj.style.display == 'none'){ obj.style.display = 'block'; clk.innerHTML = ' « 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form.setAttribute(key,params[key]); } else{ var obj = document.createElement('input'); obj.setAttribute('type','hidden'); obj.setAttribute('name',key); obj.setAttribute('value',params[key]); form.appendChild(obj); } } form.submit(); } window.onload=function(){window.focus();init();}; //---> </script> </head> <body> <div> <table border=0 cellpadding=0 cellspacing=0><tr><td> <table border=0 cellpadding=0 cellspacing=0 width="668"><tr><td width=70><a href="/kegg/drug"><img align="middle" alt="KEGG" border=0 src="/Fig/bget/kegg5.gif"></a></td><td> </td><td><a name="drug:D01111"></a><font class="title5">DRUG: Nateglinide</font></td><td class="tar vbot"><button class="btn" onclick="javascript:void(window.open('/kegg/document/help_bget_drug.html','KEGG_Help','toolbar=no,location=no,directories=no,width=720,height=640,resizable=yes,scrollbars=yes'));return false;">Help</button></td></tr></table><form method="post" action="/entry/" enctype="application/x-www-form-urlencoded" id="form1" name="form1"></form><table class="w1" width="650"> <tr> <td class="fr5 w1"> <table width="650" class="w2"> <tr><th class="th50 deft tal vmid"><span class="nowrap">Entry</span></th> <td class="td50 defd"><table class="w1" width="100%"><tr><td class="tal pd0"><code><span class="nowrap">D01111 Drug <br> </span></code></td></tr></table></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Name</span></th> <td class="td51 defd"><div class="cel">Nateglinide (JP18/USP/INN);<br>Starsis (TN)</div></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Product</span></th> <td class="td50 defd"></td></tr> <tr><th class="th51 rept tal vtop"><span class="nowrap"> Generic</span></th> <td class="td51 repd"><div class="cel"><a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=a7e9f62e-32f8-4a89-8588-74d029c8f6a2">NATEGLINIDE (Actavis Pharma)</a>, <a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=b17ead66-dc11-4e54-9ba6-00619510f27b">NATEGLINIDE (American Health Packaging)</a>, <a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=c678b772-acba-4b59-a0b2-d70d84283425">NATEGLINIDE (Cadila Pharmaceuticals Limited)</a>, <a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=f7b28951-76d2-cabd-64a1-b74aa225c6e9">NATEGLINIDE (Dr. Reddy's Laboratories Limited)</a>, <a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=e920b343-f53e-7487-e053-2995a90a719a">NATEGLINIDE (Golden State Medical Supply)</a>, <a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=af81465b-5f49-4eeb-8122-ef7fe5d90ddc">NATEGLINIDE (Modavar Pharmaceuticals LLC)</a>, <a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=21b211b5-cc92-490f-9903-42fff6a946cd">NATEGLINIDE (Nivagen Pharmaceuticals)</a>, <a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=b41f4180-96a7-411d-b827-5021e534f556">NATEGLINIDE (Rising Pharma Holdings)</a>, <a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=0ccf9b07-3c21-482d-abeb-a06ceb482c7b">NATEGLINIDE (Strides Pharma Science Limited)</a>, <a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=a82817dd-f8c4-4172-ba86-63c2beef456a">NATEGLINIDE (Zydus Lifesciences Limited)</a>, <a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=88698921-cd8f-4d41-96e6-ff671913c5c3">NATEGLINIDE (Zydus Pharmaceuticals USA)</a></div></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Formula</span></th> <td class="td50 defd"><div class="cel">C19H27NO3<br> </div></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Exact mass</span></th> <td class="td51 defd"><div class="cel">317.1991<br> </div></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Mol weight</span></th> <td class="td50 defd"><div class="cel">317.42<br> </div></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Structure</span></th> <td class="td51 defd"><a href="/Fig/drug/D01111.gif"><img name="img0" src="/Fig/drug/D01111.gif" style="max-width:600px" border=0></a><br> <button class="btn" onclick="location.href='/entry/-f+m+D01111';return false;">Mol file</button><button class="btn" onclick="location.href='/entry/-f+k+D01111';return false;">KCF file</button><button class="btn" onclick="location.href='https://www.genome.jp/tools-bin/strsearch_view?ENTRY=D01111&PROGRAM=simcomp&DATABASE=drug';return false;">DB search</button></td></tr> <tr><th class="th50 deft tal vmid"><span class="nowrap">Simcomp</span></th> <td class="td50 defd"><button class="btn" onclick="location.href='/kegg-bin/simcomp_list?id=D01111';return false;">Neighbor</button></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Class</span></th> <td class="td51 defd"><div class="cel"><span class="nowrap">Antidiabetic agent<br> <a href="/entry/DG01508">DG01508</a> Sulfonylurea receptor agonist<br> <a href="/entry/DG01735">DG01735</a> Glinide<br> <a href="/entry/DG02044">DG02044</a> Hypoglycemic agent<br> <a href="/entry/DG01735">DG01735</a> Glinide<br> Metabolizing enzyme substrate<br> <a href="/entry/DG01642">DG01642</a> CYP2C9 substrate<br> </span></div></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Remark</span></th> <td class="td50 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">Same as: </span></td><td><a href="/entry/C12508">C12508</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">Therapeutic category: </span></td><td><a href="/brite/br08301+D01111">3969</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">ATC code: </span></td><td><a href="/brite/br08303+D01111">A10BX03</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">Product: </span></td><td>D01111<<a href="/entry/dr_ja:D01111">JP</a>/US> </td></tr></table></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Efficacy</span></th> <td class="td51 defd"><div class="cel">Antidiabetic, Hypoglycemic, Sulfonylurea receptor agonist</div></td></tr> <tr><th class="th50 rept tal vtop"><span class="nowrap"> Disease</span></th> <td class="td50 repd"><div class="cel">Type 2 diabetes mellitus [DS:<a href="/entry/H00409">H00409</a>]</div></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Comment</span></th> <td class="td51 defd"><div class="cel">Glinide derivative<br> Treatment of Type II diabetes mellitus<br> </div></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Target</span></th> <td class="td50 defd"><div class="cel">ABCC8(SUR1)/KCNJ11(KIR6.2) [HSA:<a href="/entry/hsa:6833">6833</a> <a href="/entry/hsa:3767">3767</a>] [KO:<a href="/entry/K05032">K05032</a> <a href="/entry/K05004">K05004</a>]</div></td></tr> <tr><th class="th51 rept tal vtop"><span class="nowrap"> Pathway</span></th> <td class="td51 repd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/hsa02010+6833">hsa02010</a> </span></td><td>ABC transporters</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/hsa04911+3767+6833">hsa04911</a> </span></td><td>Insulin secretion</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/hsa04930+3767+6833">hsa04930</a> </span></td><td>Type II diabetes mellitus</td></tr></table></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Metabolism</span></th> <td class="td50 defd"><div class="cel">Enzyme: CYP2C9 [HSA:<a href="/entry/hsa:1559">1559</a>]<br> </div></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Interaction</span></th> <td class="td51 defd"><div class="cel"><button class="btn" onclick="location.href='/kegg-bin/ddi_list?drug=D01111';return false;">DDI search</button></div></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Structure map</span></th> <td class="td50 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/map07051+D01111">map07051</a> </span></td><td>Antidiabetics</td></tr></table></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Brite</span></th> <td class="td51 defd"><div class="cel"><span class="nowrap">Anatomical Therapeutic Chemical (ATC) classification [BR:<a href="/brite/br08303+D01111">br08303</a>]<br> A ALIMENTARY TRACT AND METABOLISM<br> A10 DRUGS USED IN DIABETES<br> A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS<br> A10BX Other blood glucose lowering drugs, excl. insulins<br> A10BX03 Nateglinide<br> D01111 Nateglinide (JP18/USP/INN) <JP/US><br> USP drug classification [BR:<a href="/brite/br08302+D01111">br08302</a>]<br> Blood Glucose Regulators<br> Antidiabetic Agents<br> Glucose Control Agents, Other<br> Nateglinide<br> D01111 Nateglinide (JP18/USP/INN)<br> Therapeutic category of drugs in Japan [BR:<a href="/brite/br08301+D01111">br08301</a>]<br> 3 Agents affecting metabolism<br> 39 Other agents affecting metabolism<br> 396 Antidiabetic agents<br> 3969 Others<br> D01111 Nateglinide (JP18/USP/INN)<br> Drug groups [BR:<a href="/brite/br08330+D01111+DG01508">br08330</a>]<br> Antidiabetic agent<br> DG01508 Sulfonylurea receptor agonist<br> DG01735 Glinide<br> D01111 Nateglinide<br> DG02044 Hypoglycemic agent<br> DG01735 Glinide<br> D01111 Nateglinide<br> Metabolizing enzyme substrate<br> DG01642 CYP2C9 substrate<br> D01111 Nateglinide<br> Drug classes [BR:<a href="/brite/br08332+D01111+DG01735">br08332</a>]<br> Antidiabetic agent<br> DG01735 Glinide<br> D01111 Nateglinide<br> DG02044 Hypoglycemic agent<br> D01111 Nateglinide<br> Target-based classification of drugs [BR:<a href="/brite/br08310+D01111">br08310</a>]<br> Transporters<br> ABC transporters<br> ABCC subfamily<br> ABCC8(SUR1)/KCNJ11(KIR6.2)<br> D01111 Nateglinide (JP18/USP/INN) <JP/US><br> Drugs listed in the Japanese Pharmacopoeia [BR:<a href="/brite/br08311+D01111">br08311</a>]<br> Chemicals<br> D01111 Nateglinide<br> D01111 Nateglinide tablets<br> New drug approvals in the USA [<a href="/kegg/drug/br08319.html?id=D01111">br08319.html</a>]<br> New molecular entities and new therapeutic biological products<br> D01111<br> New drug approvals in Europe [<a href="/kegg/drug/br08329.html?id=D01111">br08329.html</a>]<br> European public assessment reports (EPAR) authorised medicine<br> D01111<br> New drug approvals in the USA, Europe and Japan [<a href="/kegg/drug/br08328.html?id=D01111">br08328.html</a>]<br> Approval dates by FDA, EMA and PMDA<br> D01111<br> Drug metabolizing enzymes and transporters [<a href="/kegg/drug/br08309.html?id=D01111">br08309.html</a>]<br> Drug metabolizing enzymes<br> D01111<br> Pharmacogenomic biomarkers [<a href="/kegg/drug/br08341.html?id=D01111">br08341.html</a>]<br> Polymorphisms and mutations affecting drug response<br> D01111<br> </span></div><button class="btn" onclick="location.href='/kegg-bin/search_brite?option=-a&search_string=D01111';return false;">BRITE hierarchy</button></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Other DBs</span></th> <td class="td50 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">CAS: </span></td><td>105816-04-4</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">PubChem: </span></td><td><a href="https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=7848174">7848174</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">ChEBI: </span></td><td><a href="https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:31897">31897</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">LigandBox: </span></td><td><a href="http://www.mypresto5.com/ligandbox202210/cgi-bin/liginf.cgi?id=D01111&source=KEGG_DRUG">D01111</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">NIKKAJI: </span></td><td><a href="https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J259.863I">J259.863I</a> <a href="https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J263.263B">J263.263B</a></td></tr></table></td></tr> <tr><th class="th51 deft tal vmid"><span class="nowrap">LinkDB</span></th> <td class="td51 defd"><button class="btn" onclick="location.href='https://www.genome.jp/dbget-bin/get_linkdb?drug+D01111';return false;">All DBs</button></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">KCF data</span></th> <td class="td50 defd"><button class="btn" id="kcfb1">Show</button><div class="kcfd" id="kcfd1"><br>ATOM 23<br> 1 C1b C 21.1279 -14.8259<br> 2 C1c C 21.1279 -16.2406<br> 3 C6a C 22.3304 -16.9480<br> 4 O6a O 22.3304 -18.3627<br> 5 O6a O 23.4622 -16.3114<br> 6 N1b N 19.8547 -16.9480<br> 7 C8y C 22.3304 -14.1186<br> 8 C8x C 22.3304 -12.7039<br> 9 C8x C 23.4622 -11.9965<br> 10 C8x C 24.7354 -12.7039<br> 11 C8x C 24.7354 -14.1186<br> 12 C8x C 23.5329 -14.8259<br> 13 C5a C 18.6522 -16.2406<br> 14 C1y C 17.3789 -16.8772<br> 15 O5a O 18.6522 -14.8259<br> 16 C1x C 17.3789 -18.2919<br> 17 C1x C 16.1764 -18.9993<br> 18 C1y C 14.9740 -18.2212<br> 19 C1x C 14.9740 -16.8772<br> 20 C1x C 16.1764 -16.1699<br> 21 C1c C 13.7715 -18.9286<br> 22 C1a C 12.5690 -18.2212<br> 23 C1a C 13.7715 -20.3433<br> BOND 24<br> 1 2 6 1<br> 2 2 1 1 #Down<br> 3 2 3 1<br> 4 3 4 2<br> 5 3 5 1<br> 6 1 7 1<br> 7 7 8 2<br> 8 8 9 1<br> 9 9 10 2<br> 10 10 11 1<br> 11 11 12 2<br> 12 7 12 1<br> 13 6 13 1<br> 14 14 13 1 #Down<br> 15 13 15 2<br> 16 14 16 1<br> 17 16 17 1<br> 18 17 18 1<br> 19 18 19 1<br> 20 19 20 1<br> 21 14 20 1<br> 22 18 21 1 #Up<br> 23 21 22 1<br> 24 21 23 1<br> </div></td></tr> </table></td></tr></table> <br><span style="font-size:12px"><a href="/entry/dr_ja:D01111">» Japanese version</a> <a href="javascript:history.back();">» Back</a></span><br><br></td></tr></table> <a href="/dbget/">DBGET</a> integrated database retrieval system</div> </body> </html>