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class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Dva_enzima"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.1</span> <span>Dva enzima</span> </div> </a> <ul id="toc-Dva_enzima-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Jedan_enzim_sa_dva_katalitska_mjesta" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Jedan_enzim_sa_dva_katalitska_mjesta"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.2</span> <span>Jedan enzim sa dva katalitska mjesta</span> </div> </a> <ul id="toc-Jedan_enzim_sa_dva_katalitska_mjesta-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Genetička_lokcija" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Genetička_lokcija"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Genetička lokcija</span> </div> </a> <ul id="toc-Genetička_lokcija-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Klinički_značaj" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Klinički_značaj"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Klinički značaj</span> </div> </a> <ul id="toc-Klinički_značaj-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Reference" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Reference"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Reference</span> </div> </a> <ul id="toc-Reference-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Vanjski_linovi" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Vanjski_linovi"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Vanjski linovi</span> </div> </a> <ul id="toc-Vanjski_linovi-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Sadržaj" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Uključi/isključi sadržaj" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Uključi/isključi sadržaj</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Enzim razgradnje glikogenskih grana</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Idi na članak na drugom jeziku. Dostupno na 8 jezika" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-8" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">8 jezika</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Glykogen-Debranching-Enzym" title="Glykogen-Debranching-Enzym – njemački" lang="de" hreflang="de" data-title="Glykogen-Debranching-Enzym" data-language-autonym="Deutsch" data-language-local-name="njemački" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Glycogen_debranching_enzyme" title="Glycogen debranching enzyme – engleski" lang="en" hreflang="en" data-title="Glycogen debranching enzyme" data-language-autonym="English" data-language-local-name="engleski" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Enzima_desramificadora_del_gluc%C3%B3geno" title="Enzima desramificadora del glucógeno – španski" lang="es" hreflang="es" data-title="Enzima desramificadora del glucógeno" data-language-autonym="Español" data-language-local-name="španski" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%A2%D9%86%D8%B2%DB%8C%D9%85_%D8%B4%D8%A7%D8%AE%D9%87%E2%80%8C%D8%B4%DA%A9%D9%86_%DA%AF%D9%84%DB%8C%DA%A9%D9%88%DA%98%D9%86" title="آنزیم شاخه‌شکن گلیکوژن – perzijski" lang="fa" hreflang="fa" data-title="آنزیم شاخه‌شکن گلیکوژن" data-language-autonym="فارسی" data-language-local-name="perzijski" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Enzyme_de_d%C3%A9branchement_du_glycog%C3%A8ne" title="Enzyme de débranchement du glycogène – francuski" lang="fr" hreflang="fr" data-title="Enzyme de débranchement du glycogène" data-language-autonym="Français" data-language-local-name="francuski" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EA%B8%80%EB%A6%AC%EC%BD%94%EC%A0%A0_%ED%83%88%EB%B6%84%EC%A7%80%ED%9A%A8%EC%86%8C" title="글리코젠 탈분지효소 – korejski" lang="ko" hreflang="ko" data-title="글리코젠 탈분지효소" data-language-autonym="한국어" data-language-local-name="korejski" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Enzim_razgradnje_glikogenskih_grana" title="Enzim razgradnje glikogenskih grana – srpski" lang="sr" hreflang="sr" data-title="Enzim razgradnje glikogenskih grana" data-language-autonym="Српски / srpski" data-language-local-name="srpski" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%90%D0%BC%D1%96%D0%BB%D0%BE-1,6-%D0%B3%D0%BB%D1%8E%D0%BA%D0%BE%D0%B7%D0%B8%D0%B4%D0%B0%D0%B7%D0%B0" title="Аміло-1,6-глюкозидаза – ukrajinski" lang="uk" hreflang="uk" data-title="Аміло-1,6-глюкозидаза" data-language-autonym="Українська" data-language-local-name="ukrajinski" class="interlanguage-link-target"><span>Українська</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q1532471#sitelinks-wikipedia" 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id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="bs" dir="ltr"><table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">Enzim razgradnje glikogenskih grana</th></tr><tr><td colspan="4" style="text-align:center"><span typeof="mw:File"><a href="/wiki/Datoteka:Function_and_Structure_of_Eukaryotic_Glycogen_Debranching_Enzyme.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/b/bf/Function_and_Structure_of_Eukaryotic_Glycogen_Debranching_Enzyme.jpg/250px-Function_and_Structure_of_Eukaryotic_Glycogen_Debranching_Enzyme.jpg" decoding="async" width="250" height="174" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/bf/Function_and_Structure_of_Eukaryotic_Glycogen_Debranching_Enzyme.jpg/375px-Function_and_Structure_of_Eukaryotic_Glycogen_Debranching_Enzyme.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/bf/Function_and_Structure_of_Eukaryotic_Glycogen_Debranching_Enzyme.jpg/500px-Function_and_Structure_of_Eukaryotic_Glycogen_Debranching_Enzyme.jpg 2x" data-file-width="2824" data-file-height="1969" /></a></span></td></tr><tr><th colspan="4" style="text-align:center;background-color:#ddd">Identifikatori</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><span class="plainlinks"><a href="/wiki/Nomenklatura_gena" class="mw-redirect" title="Nomenklatura gena">Aliasi</a></span></th><td colspan="3" style="background:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/321">AGL</a></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Vanjski ID-jevi</th><td colspan="3" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/OMIM" title="OMIM">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/610860">610860</a> <a href="/wiki/Informatika_o_mi%C5%A1jem_genomu" title="Informatika o mišjem genomu">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:1924809">1924809</a> <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=536">536</a> <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=AGL">AGL</a> </span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="mw-collapsible mw-collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Lokacija gena (<a href="/wiki/Ljudski_genom" title="Ljudski genom">čovjek</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/Datoteka:Ideogram_human_chromosome_1.svg" class="mw-file-description" title="Hromosom 1 (čovjek)"><img alt="Hromosom 1 (čovjek)" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Ideogram_human_chromosome_1.svg/300px-Ideogram_human_chromosome_1.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Ideogram_human_chromosome_1.svg/450px-Ideogram_human_chromosome_1.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Ideogram_human_chromosome_1.svg/600px-Ideogram_human_chromosome_1.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Hromosom" title="Hromosom">Hrom.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Hromosom_1_(%C4%8Dovjek)" class="mw-redirect" title="Hromosom 1 (čovjek)">Hromosom 1 (čovjek)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/Datoteka:Human_chromosome_1_ideogram.svg" class="mw-file-description" title="Hromosom 1 (čovjek)"><img alt="Hromosom 1 (čovjek)" src="//upload.wikimedia.org/wikipedia/commons/thumb/7/7e/Human_chromosome_1_ideogram.svg/300px-Human_chromosome_1_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/7e/Human_chromosome_1_ideogram.svg/450px-Human_chromosome_1_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/7e/Human_chromosome_1_ideogram.svg/600px-Human_chromosome_1_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 112.61318152771px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/Datoteka:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomska lokacija za Enzim razgradnje glikogenskih grana"><img alt="Genomska lokacija za Enzim razgradnje glikogenskih grana" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 118.6px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/Datoteka:Red_rectangle_2x18.png" class="mw-file-description" title="Genomska lokacija za Enzim razgradnje glikogenskih grana"><img alt="Genomska lokacija za Enzim razgradnje glikogenskih grana" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Lokus_(gen)" title="Lokus (gen)">Bend</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">1p21.2</span></td><th scope="row" style="background-color:#c3fdb8">Početak</th><td style="background-color:#eee"><span class="plainlinks">99,850,361 <a href="/wiki/Bazni_par" title="Bazni par">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Kraj</th><td style="background-color:#eee"><span class="plainlinks">99,924,023 <a href="/wiki/Bazni_par" title="Bazni par">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="mw-collapsible mw-collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Lokacija gena (<a href="/wiki/Laboratorijski_mi%C5%A1" title="Laboratorijski miš">miš</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/Datoteka:Ideogram_house_mouse_chromosome_3.svg" class="mw-file-description" title="Hromosom 3 (miš)"><img alt="Hromosom 3 (miš)" src="//upload.wikimedia.org/wikipedia/commons/thumb/0/08/Ideogram_house_mouse_chromosome_3.svg/260px-Ideogram_house_mouse_chromosome_3.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/08/Ideogram_house_mouse_chromosome_3.svg/390px-Ideogram_house_mouse_chromosome_3.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/08/Ideogram_house_mouse_chromosome_3.svg/520px-Ideogram_house_mouse_chromosome_3.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Hromosom" title="Hromosom">Hrom.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks">Hromosom 3 (miš)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/Datoteka:Ideogram_of_house_mouse_chromosome_3.svg" class="mw-file-description" title="Hromosom 3 (miš)"><img alt="Hromosom 3 (miš)" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/f2/Ideogram_of_house_mouse_chromosome_3.svg/300px-Ideogram_of_house_mouse_chromosome_3.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/f2/Ideogram_of_house_mouse_chromosome_3.svg/450px-Ideogram_of_house_mouse_chromosome_3.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/f2/Ideogram_of_house_mouse_chromosome_3.svg/600px-Ideogram_of_house_mouse_chromosome_3.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 208.83711846235px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/Datoteka:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomska lokacija za Enzim razgradnje glikogenskih grana"><img alt="Genomska lokacija za Enzim razgradnje glikogenskih grana" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 214.8px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/Datoteka:Red_rectangle_2x18.png" class="mw-file-description" title="Genomska lokacija za Enzim razgradnje glikogenskih grana"><img alt="Genomska lokacija za Enzim razgradnje glikogenskih grana" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Lokus_(gen)" title="Lokus (gen)">Bend</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">3|3 G1</span></td><th scope="row" style="background-color:#c3fdb8">Početak</th><td style="background-color:#eee"><span class="plainlinks">116,533,648 <a href="/wiki/Bazni_par" title="Bazni par">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Kraj</th><td style="background-color:#eee"><span class="plainlinks">116,601,815 <a href="/wiki/Bazni_par" title="Bazni par">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="mw-collapsible mw-collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Ontologija_gena" title="Ontologija gena">Ontologija gena</a></th></tr><tr><th style="background-color:#c3fdb8">Molekularna funkcija</th><td style="background-color:#eee"><span class="plainlinks"><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016740">aktivnost sa transferazom</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016757">glycosyltransferase activity</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016798">hydrolase activity, acting on glycosyl bonds</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005515,">GO:0001948, GO:0016582 vezivanje za proteine</a><br /><big>•</big> <a href="https://www.wikidata.org/wiki/Q1735592" class="extiw" title="d:Q1735592">catalytic activity</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016787">hydrolase activity</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004134">4-alpha-glucanotransferase activity</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004135">amylo-alpha-1,6-glucosidase activity</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004133">glycogen debranching enzyme activity</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030246">carbohydrate binding</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030247">polysaccharide binding</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031593">polyubiquitin modification-dependent protein binding</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0102500">beta-maltose 4-alpha-glucanotransferase activity</a><br /></span></td></tr><tr><th style="background-color:#c3fdb8">Ćelijska komponenta</th><td style="background-color:#eee"><span class="plainlinks"><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005737">citoplazma</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005829">citosol</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043033">isoamylase complex</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005576">extracellular region</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0034774">secretory granule lumen</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1904813">ficolin-1-rich granule lumen</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005634">jedro</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016234">inclusion body</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016529">Sarkoplazmatski retikulum</a><br /></span></td></tr><tr><th style="background-color:#c3fdb8">Biološki proces</th><td style="background-color:#eee"><span class="plainlinks"><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005978">glycogen biosynthetic process</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005980">Glikogenoliza</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008152">metabolizam</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043312">neutrophil degranulation</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005977">glycogen metabolic process</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007584">response to nutrient</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009725">response to hormone</a><br /><big>•</big> <a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051384">response to glucocorticoid</a><br /></span></td></tr><tr><td colspan="4" style="background-color:#eee;text-align:center">Izvori:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Homologija_sekvence#Ortologija" title="Homologija sekvence">Ortolozi</a></th></tr><tr><th scope="row" style="background-color:#c3fdb8">Vrste</th><td><b>Čovjek</b></td><td><b>Miš</b></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=178&rn=1">178</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=77559&rn=1">77559</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000162688;db=core">ENSG00000162688</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000033400;db=core">ENSMUSG00000033400</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P35573">P35573</a></p></td></tr></tbody></table></td><td><table style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks">n/a</p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (mRNK)</th><td><table class="mw-collapsible mw-collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_000028">NM_000028</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_000642">NM_000642</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_000643">NM_000643</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_000644">NM_000644</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_000645">NM_000645</a><br /></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_000646">NM_000646</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001081326">NM_001081326</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001362367">NM_001362367</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (bjelančevina)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_000019">NP_000019</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_000633">NP_000633</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_000634">NP_000634</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_000635">NP_000635</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_000637">NP_000637</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks">n/a</span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Lokacija (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr1:99850361-99924023">Chr 1: 99.85 – 99.92 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr3:116533648-116601815">Chr 3: 116.53 – 116.6 Mb</a></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/PubMed" title="PubMed">PubMed</a> pretraga</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;font-size:x-small;background-color:#eee"><a href="/wiki/Wikipodaci" title="Wikipodaci">Wikipodaci</a></td></tr><tr><td colspan="4" style="text-align:center;font-size:x-small;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:#eee;text-align:center;font-size:x-small"><a href="https://www.wikidata.org/wiki/Q17815968" class="extiw" title="d:Q17815968">Pogledaj/uredi – čovjek</a></td><td colspan="2" style="background-color:#eee;text-align:center;font-size:x-small"><a href="https://www.wikidata.org/wiki/Q18268646" class="extiw" title="d:Q18268646">Pogledaj/uredi – miš</a></td></tr></tbody></table></td></tr></tbody></table> <style data-mw-deduplicate="TemplateStyles:r3638947">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}body.skin-minerva .mw-parser-output .infobox-header,body.skin-minerva .mw-parser-output .infobox-subheader,body.skin-minerva .mw-parser-output .infobox-above,body.skin-minerva .mw-parser-output .infobox-title,body.skin-minerva .mw-parser-output .infobox-image,body.skin-minerva .mw-parser-output .infobox-full-data,body.skin-minerva .mw-parser-output .infobox-below{text-align:center}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data div{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data div{background:#1f1f23!important;color:#f8f9fa}}</style><table class="infobox"><tbody><tr><th colspan="2" class="infobox-above">Amilo-α-1,6-glukozidaza</th></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Identifikatori</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/EC_broj_enzima" title="EC broj enzima">EC broj</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.qmul.ac.uk/sbcs/iubmb/enzyme/EC3/2/1/33.html">3.2.1.33</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/CAS_registarski_broj" title="CAS registarski broj">CAS broj</a></th><td class="infobox-data" style="background-color: #eee"><a class="external text" href="//tools.wmflabs.org/magnustools/cas.php?language=en&cas=9012-47-9&title=">9012-47-9 </a></td></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Baze podataka</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/IntEnz" title="IntEnz">IntEnz</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/intenz/query?cmd=SearchEC&ec=3.2.1.33">IntEnz pregled</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/BRENDA" title="BRENDA">BRENDA</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="http://www.brenda-enzymes.org/enzyme.php?ecno=3.2.1.33">BRENDA unos</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/ExPASy" class="mw-redirect" title="ExPASy">ExPASy</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://enzyme.expasy.org/EC/3.2.1.33">NiceZyme pregled</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/KEGG" title="KEGG">KEGG</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.genome.jp/dbget-bin/www_bget?enzyme+3.2.1.33">KEGG unos</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/MetaCyc" title="MetaCyc">MetaCyc</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://biocyc.org/META/substring-search?type=NIL&object=3.2.1.33">metabolički put</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/PRIAM_enzim_specifi%C4%8Dni_profili" class="mw-redirect" title="PRIAM enzim specifični profili">PRIAM</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="http://priam.prabi.fr/cgi-bin/PRIAM_profiles_CurrentRelease.pl?EC=3.2.1.33">profil</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Proteinska_banka_podataka" title="Proteinska banka podataka">PDB</a> strukture</th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity.rcsb_ec_lineage.id:3.2.1.33">RCSB PDB</a> <a rel="nofollow" class="external text" href="https://pdbj.org/mine/sql?query=SELECT+DISTINCT+pdbid+FROM+entity+WHERE+entity.pdbx_ec%3D%273.2.1.33%27">PDBj</a> <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/entry/search/index?ec_number:3.2.1.33">PDBe</a> <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/enzymes/GetPage.pl?ec_number=3.2.1.33">PDBsum</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Ontologija_gena" title="Ontologija gena">Ontologija gena</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004135">AmiGO </a> / <a rel="nofollow" class="external text" href="//www.ebi.ac.uk/QuickGO/term/GO:0004135">QuickGO</a></td></tr><tr><td colspan="2" class="infobox-full-data" style="background-color: #eee"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r3638947"><table class="infobox mw-collapsible mw-collapsed" style="float:none; clear:none; margin:0; border-width:0; border-collapse:collapse; text-align:left; width:100%"><tbody><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Pretraga</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/PubMed_Central" title="PubMed Central">PMC</a></th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&term=3.2.1.33%5BEC/RN%20Number%5D%20AND%20pubmed%20pmc%20local%5Bsb%5D">članci</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/PubMed" title="PubMed">PubMed</a></th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&term=3.2.1.33%5BEC/RN%20Number%5D">članci</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/Nacionalni_centar_za_biotehnolo%C5%A1ke_informacije" title="Nacionalni centar za biotehnološke informacije">NCBI</a></th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/protein?term=3.2.1.33%5BEC/RN%20Number%5D">proteini</a></td></tr></tbody></table></td></tr></tbody></table> <figure typeof="mw:File/Thumb"><a href="/wiki/Datoteka:Glykogen-schema.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/f/fe/Glykogen-schema.png/300px-Glykogen-schema.png" decoding="async" width="300" height="192" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/fe/Glykogen-schema.png/450px-Glykogen-schema.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/fe/Glykogen-schema.png/600px-Glykogen-schema.png 2x" data-file-width="796" data-file-height="510" /></a><figcaption>Prikaz procesa <a href="/wiki/Glikogenoliza" title="Glikogenoliza">glikogenolize</a></figcaption></figure> <p><b>Enzim razlaganjs glikogenskih grana</b> ili <b>Enzim kresanja grana</b> je <a href="/wiki/Molekula" title="Molekula">molekula</a> koja pomaže olakšavanju razgradnje <a href="/wiki/Glikogen" title="Glikogen">glikogena</a>, koji služi kao skladište glukoze u tijelu, aktivnošću <a href="/w/index.php?title=Glukoziltransferaza&action=edit&redlink=1" class="new" title="Glukoziltransferaza (stranica ne postoji)">glukoziltransferaza</a> i <a href="/wiki/Glukozidaza" class="mw-redirect" title="Glukozidaza">glukozidaza</a>. Zajedno sa <a href="/wiki/Fosforilaza" title="Fosforilaza">fosforilazama</a>, ovi enzimi mobiliziraju rezerve <a href="/wiki/Glukoza" title="Glukoza">glukoze</a> iz glikogenskih naslaga u <a href="/wiki/Mi%C5%A1i%C4%87" title="Mišić">mišićima</a> i <a href="/wiki/Jetra" title="Jetra">jetri</a>. Ovo predstavlja glavni izvor energetskih rezervi u većini <a href="/wiki/Organizam" class="mw-redirect" title="Organizam">organizama</a>. Razgradnja glikogena u tijelu je visoko regulirana, posebno u <a href="/wiki/Jetra" title="Jetra">jetri</a>, putem raznih <a href="/wiki/Hormon" title="Hormon">hormona</a>, uključujući <a href="/wiki/Insulin" title="Insulin">insulin</a> i <a href="/wiki/Glukagon" title="Glukagon">glukagon</a>, da bi se održao homeostatski balans razine glukoze u krvi. Kada je razgradnja glikogena ugrožena <a href="/wiki/Mutacija" title="Mutacija">mutacijama</a> u sintezi ovog enzima, javljaju se metaboličke bolesti, kao što je bolest <a href="/w/index.php?title=Bolest_glikogenske_pothranjenosi_tipa_III&action=edit&redlink=1" class="new" title="Bolest glikogenske pothranjenosi tipa III (stranica ne postoji)">bolest glikogenske pothranjenosi tipa III</a>. </p><p>Kod <a href="/wiki/Sisar" class="mw-redirect" title="Sisar">sisara</a>, <a href="/w/index.php?title=Kvasc&action=edit&redlink=1" class="new" title="Kvasc (stranica ne postoji)">kvasca</a> i nekih <a href="/wiki/Bakterija" title="Bakterija">bakterija</a>, <a href="/w/index.php?title=Glukoziltransferaza&action=edit&redlink=1" class="new" title="Glukoziltransferaza (stranica ne postoji)">glukoziltransferaza</a> i <a href="/wiki/Glukozidaza" class="mw-redirect" title="Glukozidaza">glukozidaza</a> se priređuju jednim <a href="/wiki/Enzim" title="Enzim">enzimom</a>, dok u <i><a href="/wiki/E._coli" class="mw-redirect" title="E. coli">E. coli</a></i> i drugih bakterija, to čine dva različita enzima, što komplicira nomenklaturu. Proteini koji kataliziraju obje funkcije se nazivaju glikogen enzimi za rszlaganje glikogenskih grana ili enzimi kresanja glikogenskih grana (GDE). Kada se glukoziltransferaza i glukozidaza kataliziraju različitim enzimima, "glikogena za skidanje grana" obično se odnosi na glukozidazni <a href="/wiki/Enzim" title="Enzim">enzim</a>. U nekim izvorima, enzim koji je sposoban samo za glukozidaze se naziva "kresajući enzim ".<sup id="cite_ref-Song_5-0" class="reference"><a href="#cite_note-Song-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Bao_6-0" class="reference"><a href="#cite_note-Bao-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <figure typeof="mw:File/Thumb"><a href="/wiki/Datoteka:Glycogen_phosphorylase_stereo.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/f/f5/Glycogen_phosphorylase_stereo.png/600px-Glycogen_phosphorylase_stereo.png" decoding="async" width="600" height="151" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/f5/Glycogen_phosphorylase_stereo.png/900px-Glycogen_phosphorylase_stereo.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/f5/Glycogen_phosphorylase_stereo.png/1200px-Glycogen_phosphorylase_stereo.png 2x" data-file-width="3380" data-file-height="852" /></a><figcaption><i>n</i>}}</figcaption></figure><p>. </p><meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Struktura_i_aktivnost">Struktura i aktivnost</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Enzim_razgradnje_glikogenskih_grana&veaction=edit&section=1" title="Uredi odlomak "Struktura i aktivnost"" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Enzim_razgradnje_glikogenskih_grana&action=edit&section=1" title="Edit section's source code: Struktura i aktivnost"><span>uredi izvor</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Dva_enzima">Dva enzima</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Enzim_razgradnje_glikogenskih_grana&veaction=edit&section=2" title="Uredi odlomak "Dva enzima"" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Enzim_razgradnje_glikogenskih_grana&action=edit&section=2" title="Edit section's source code: Dva enzima"><span>uredi izvor</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>U <i> <a href="/wiki/Escherichia_coli" title="Escherichia coli">Escherichia coli</a></i> i drugih <a href="/wiki/Bakterija" title="Bakterija">bakterija</a>, glukoziltransferaza i glukozidaza djeluju putem dva različita enzima. U <i> E. coli </i>, transfer glukoze obavlja 4-alfa-glukanotransferaza, protein od 78,5 kDa,koji je kodiran <a href="/wiki/Gen" title="Gen">genom</a> malQ. Drugi protein, zvani enzim za otklanjane grana, razlaganje obavlja alfa-1 , 6-glukoza. Ovaj enzim ima molekulsku masu od 73,6 kDa, a kodiran genom glgX. Aktivnost ova dva enzima ne odvija se uvijek nužno zajedno. U <i> E. coli </i> glgX selektivno katalizira razlaganje 4-podjedinične grane, bez akcije glukanotransferaze. Proizvod ovog razlaganja, <a href="/w/index.php?title=Maltotetraoza&action=edit&redlink=1" class="new" title="Maltotetraoza (stranica ne postoji)">maltotetraoza</a>, dodatno degradira maltodekstrin fosforilaza.<sup id="cite_ref-Chen_7-0" class="reference"><a href="#cite_note-Chen-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-UniProt_P35573_8-0" class="reference"><a href="#cite_note-UniProt_P35573-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Gillard_80_9-0" class="reference"><a href="#cite_note-Gillard_80-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p><p>Gen GlgX <i>E. coli</i> je strukturno sličan proteinu <a href="/w/index.php?title=Izoamilaza&action=edit&redlink=1" class="new" title="Izoamilaza (stranica ne postoji)">izoamilazi</a>. Monomerni protein sadrži centraln domen u kojem je osam paralelnih beta-lanaca okružeo sa osam paralelnih alfa niti. Unutar ove strukture je rascjep dužine 26 <a href="/wiki/Angstrem" class="mw-redirect" title="Angstrem">angstrema</a>, a širok 9 angstrema, koji sadrži aromatske ostatke za koje se smatra da, prije razlaganja, stabiliziraju četveroglukozne grana.<sup id="cite_ref-Song_5-1" class="reference"><a href="#cite_note-Song-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Jedan_enzim_sa_dva_katalitska_mjesta">Jedan enzim sa dva katalitska mjesta</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Enzim_razgradnje_glikogenskih_grana&veaction=edit&section=3" title="Uredi odlomak "Jedan enzim sa dva katalitska mjesta"" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Enzim_razgradnje_glikogenskih_grana&action=edit&section=3" title="Edit section's source code: Jedan enzim sa dva katalitska mjesta"><span>uredi izvor</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Kod <a href="/wiki/Sisar" class="mw-redirect" title="Sisar">sisara</a> i <a href="/wiki/Kvasac" class="mw-redirect" title="Kvasac">kvasaca</a>, jedan enzim obavlja obje funkcije uklanjanja glikogenskih grana. Ljudski enzim uklanjanja grana glikogena debranching (gen: AGL) je monomer s molekulskom masom od 175 kDa. Dokazano je da dvije katalitske akcije AGL mogu funkcionirati neovisno jedna od druge, što pokazuje da je prisutno više aktivnih smjesta. Ova pojava je ojačana aktivnim mjestom inhibitora, kao što je polihidroksiamin, za koji je utvrđeno da inhibiraj glukozidaznu aktivnost dok transferazna nije mjerljivo promijenjena. Enzim za razlaganje glikogenskih grana je jedini poznati <a href="/wiki/Eukariot" class="mw-redirect" title="Eukariot">eukariotski</a> enzim koji sadrži više katalitskih mjesta i koji je aktivan kao monomer. </p><p>Neke studije su pokazale da je pola kvašćevih GDE <a href="/wiki/C-kraj" title="C-kraj">C-krajeva</a> je povezano sa glukozidaznom aktivnosti, dok je pola <a href="/wiki/N-kraj" title="N-kraj">N-krajeva</a> povezano sa aktivnosti glukoziltransferaze. Osim ova dva <a href="/wiki/Aktivno_mjesto" title="Aktivno mjesto">aktivna mjesta</a>, čini se da AGL sadrži itreće aktivno mjesto koji omogućava da se veže za glikogenski polimer. Iako je kompletna struktura GDE kod eukariota tek treba da se utvrdi, misli se da se vežu za šestomolekulske lance glukoze kao i razgranate glukoze, što odgovara sedam podjedinice u aktivnom mjestu, kao što je prikazano na slici ispod.<sup id="cite_ref-Gillard_10-0" class="reference"><a href="#cite_note-Gillard-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Woo_11-0" class="reference"><a href="#cite_note-Woo-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-UniProt_A8QX06_12-0" class="reference"><a href="#cite_note-UniProt_A8QX06-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-UniProt_A7ZSW4_13-0" class="reference"><a href="#cite_note-UniProt_A7ZSW4-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-UniProt_P15977_14-0" class="reference"><a href="#cite_note-UniProt_P15977-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Park_15-0" class="reference"><a href="#cite_note-Park-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Talente_16-0" class="reference"><a href="#cite_note-Talente-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Monga_17-0" class="reference"><a href="#cite_note-Monga-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Hondoh_18-0" class="reference"><a href="#cite_note-Hondoh-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-MCCarter_19-0" class="reference"><a href="#cite_note-MCCarter-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Yamamoto_20-0" class="reference"><a href="#cite_note-Yamamoto-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> </p><p><span class="mw-default-size" typeof="mw:File"><a href="/wiki/Datoteka:Hypothesized_substraight_binding_location.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/9/93/Hypothesized_substraight_binding_location.png" decoding="async" width="818" height="259" class="mw-file-element" data-file-width="818" data-file-height="259" /></a></span> </p><p>Može se uočiti da kada je glukoza u <a href="/wiki/Aktivno_mjesto" title="Aktivno mjesto">aktivnom mjesatu</a> 'A', 'B', 'C' i '0, hidrolizira se najbrže. Ovo ukazuje da je ovaj region veza lanca glikogena najjači na aktivnom mjestu, jer jača interakcija između enzima i supstrata dovodi do brže hidrolize. Unatoč ovom napretku, kompletna strukturu GDE u eukariota tek treba da se utvrdi. Enzimi koji razlažu glikogen u <a href="/wiki/Archaea" title="Archaea">archaea</a> <i><a href="/w/index.php?title=Sulfolobus_solfataricus&action=edit&redlink=1" class="new" title="Sulfolobus solfataricus (stranica ne postoji)">Sulfolobus solfataricus</a></i> je bolje okarakterizran od onih kod <a href="/wiki/Eukarioti" title="Eukarioti">eukariota</a>. GDE u <i> S. solfataricus </i> je poznat kao Trex. Iako, kao i sisarski GDE, Trex ima i amilozidazne i glukanotransferazne funkcije, Trex je strukturno sličan glgX i ima masu od 80 kD i jedno aktivno mjesto. Za razliku od glgX ili AGL, međutim, Trex u otopini postoji kao dimer i tetramer. Izgleda da oligomerni oblik Trex-a ima značajnu ulogu u izmjeni i oblik i funkcije enzima. Smatra se da dimerizacija stabilizira "fleksibilne petlje" koje se nalaze u neposrednoj blizini aktivnog mjesta. To može biti ključ za objašnjenje zašto TREX (i ne glgX) ispoljava glukoziltransferaznu aktivnost. Kao tetramera, katalitske efikasnosti TREX su povećana četiri puta, u odnosu na svoj dimerni oblik.<sup id="cite_ref-Song_5-2" class="reference"><a href="#cite_note-Song-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Woo_11-1" class="reference"><a href="#cite_note-Woo-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-UniProt_A8QX06_12-1" class="reference"><a href="#cite_note-UniProt_A8QX06-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Park_15-1" class="reference"><a href="#cite_note-Park-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Genetička_lokcija"><span id="Geneti.C4.8Dka_lokcija"></span>Genetička lokcija</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Enzim_razgradnje_glikogenskih_grana&veaction=edit&section=4" title="Uredi odlomak "Genetička lokcija"" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Enzim_razgradnje_glikogenskih_grana&action=edit&section=4" title="Edit section's source code: Genetička lokcija"><span>uredi izvor</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Službeni naziv za gen je "amylo- α-1,6- glukozidaza, α- glukanotransferaze 4-", sa službenim simbolom AGL. AGL je <a href="/wiki/Autosom" title="Autosom">autosomni</a> <a href="/wiki/Gen" title="Gen">gen</a> koji se nalazi na <a href="/wiki/Hromosom_21_(%C4%8Dovjek)" class="mw-redirect" title="Hromosom 21 (čovjek)">hromosomu 21, pozicija: lp21</a>. AGL gen sadrži upute za izradu nekoliko različitih verzija, poznatih kao <a href="/wiki/Izoforma" class="mw-redirect" title="Izoforma">izoforme</a>, enzima za razlaganje glikogenskih grana. Ove izoforme razlikuju se po veličini i ispoljavaju se u različitim tkivima, kao što su <a href="/wiki/Jetra" title="Jetra">jetra</a> i <a href="/wiki/Mi%C5%A1i%C4%87" title="Mišić">mišići</a>. Ovaj gen je studiran u detalje, jer njegova <a href="/wiki/Mutacija" title="Mutacija">mutacija</a> je uzrok bolesti skladištenja glikogena, tipa III. Gen je dug 85 kb, a ima 35 <a href="/wiki/Egzon" title="Egzon">egzona</a> i kodira za 7,0 kb-<a href="/wiki/IRNK" class="mw-redirect" title="IRNK">iRNK</a>. Translacija gena počinje u egzonu 3, koji kodira prvih 27 <a href="/wiki/Aminokiselina" title="Aminokiselina">aminokiselina</a> AGL, jer su prva dva egzona (68kb) sadrže neprevedene 5' regije. Eksoni 4-35 kodiraju preostalih 1.505 aminokiselina koje kodira AGL gen.<sup id="cite_ref-Molecule_21-0" class="reference"><a href="#cite_note-Molecule-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Gene_22-0" class="reference"><a href="#cite_note-Gene-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Shen_23-0" class="reference"><a href="#cite_note-Shen-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Kishnan_24-0" class="reference"><a href="#cite_note-Kishnan-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Klinički_značaj"><span id="Klini.C4.8Dki_zna.C4.8Daj"></span>Klinički značaj</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Enzim_razgradnje_glikogenskih_grana&veaction=edit&section=5" title="Uredi odlomak "Klinički značaj"" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Enzim_razgradnje_glikogenskih_grana&action=edit&section=5" title="Edit section's source code: Klinički značaj"><span>uredi izvor</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Kada je ugrožena aktivnost GDE, tijelo ne može efikasno otpuštati uskladišteni glikogen, pa se jvlja tip III bolesti skladištenja glikogena (zbog nedostatka enzima), što je <a href="/wiki/Autosom" title="Autosom">autosomno</a> recesivni poremećaj. Razgradnja GSD III glikogen je nepotpuna i ne postoji akumulacija abnormalnog glikogena sa kratkim vanjskim granama. </p><p>Većina pacijenata pokazuju nedostatak GDE iu jetri i mišićima (tp IIIa), iako 15% pacijenata sadrži GDE u mišićima, a koji je odsutan iz jetri (Tip IIIb). Ovisno o mjestu <a href="/wiki/Mutacije" class="mw-redirect" title="Mutacije">mutacije</a>, različite mutacije u AGL genu mogu uticati na različite izoforme <a href="/wiki/Ekspresija_gena" title="Ekspresija gena">ekspresije gena</a>. Naprimjer, mutacije koje se javljaju na egzonu 3, utiču na oblik koji djeluje na <a href="/wiki/Izoforma" class="mw-redirect" title="Izoforma">izoforme</a> koje su je prvenstveno izražene u <a href="/wiki/Jetra" title="Jetra">jetri</a>; to dovodi do pojave GSD tip III. </p><p>Ove različite manifestacije proizvode raznovrsne simptome, koji mogu biti gotovo isti kao kod tipa I GSD, uključujući i <a href="/wiki/Hepatomegalija" title="Hepatomegalija">hepatomegaliju</a>, <a href="/w/index.php?title=Hipoglikemija&action=edit&redlink=1" class="new" title="Hipoglikemija (stranica ne postoji)">hipoglikemiju</a> kod djece, nizak rast, <a href="/wiki/Miopatija" title="Miopatija">miopatije</a> i <a href="/wiki/Kardiomiopatija" title="Kardiomiopatija">kardiopatije</a>. </p><p>Pacijenti sa tipom IIIa često imaju simptome koji se odnose na bolesti jetre i progresiju u mišićnima, sa varijacijama koji su uvjetovani godinom početka, stopom progresije i ozbiljnosti bolesti. Pacijenti s Tip IIIb obično simptome koji se odnose na bolest jetre.<sup id="cite_ref-Kishnan_24-1" class="reference"><a href="#cite_note-Kishnan-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup> Pacijenti sa tipom III se razlikuju po povišenim enzimom jetre, sa normalnim razinam <a href="/wiki/Mokra%C4%87na_kiselina" title="Mokraćna kiselina">mokraćne kiseline</a> i laktata u krvi, za razliku od drugih oblika GSD. U pacijenata sa uključenošću mišića, tip IIIa, mišićn slabost postaje dominantna u odrasloj dobi i može dovesti do <a href="/w/index.php?title=Hipertofija&action=edit&redlink=1" class="new" title="Hipertofija (stranica ne postoji)">hipertrofije</a> srčanih komora i distalnih mišića. </p> <div class="mw-heading mw-heading2"><h2 id="Reference">Reference</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Enzim_razgradnje_glikogenskih_grana&veaction=edit&section=6" title="Uredi odlomak "Reference"" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Enzim_razgradnje_glikogenskih_grana&action=edit&section=6" title="Edit section's source code: Reference"><span>uredi izvor</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r3312388">.mw-parser-output .reflist{font-size:90%;margin-bottom:0.5em;list-style-type:decimal}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist reflist-columns references-column-width reflist-columns-2" style=""> <ol class="references"> <li id="cite_note-refGRCh38Ensembl-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCh38Ensembl_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000162688">GRCh38: Ensembl release 89: ENSG00000162688</a> - <a href="/wiki/Ensembl_projekt_genomskih_podataka" title="Ensembl projekt genomskih podataka">Ensembl</a>, maj 2017</span> </li> <li id="cite_note-refGRCm38Ensembl-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCm38Ensembl_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" 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a{background:linear-gradient(transparent,transparent),url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription a,.mw-parser-output .citation .cs1-lock-subscription a{background:linear-gradient(transparent,transparent),url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-ws-icon a{background:linear-gradient(transparent,transparent),url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-maint{display:none;color:#33aa33;margin-left:0.3em}.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=178">"Human PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=National+Center+for+Biotechnology+Information%2C+U.S.+National+Library+of+Medicine&rft.atitle=Human+PubMed+Reference%3A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3DLink%26LinkName%3Dgene_pubmed%26from_uid%3D178&rfr_id=info%3Asid%2Fbs.wikipedia.org%3AEnzim+razgradnje+glikogenskih+grana" class="Z3988"></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-4">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r3303350"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=77559">"Mouse PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=National+Center+for+Biotechnology+Information%2C+U.S.+National+Library+of+Medicine&rft.atitle=Mouse+PubMed+Reference%3A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3DLink%26LinkName%3Dgene_pubmed%26from_uid%3D77559&rfr_id=info%3Asid%2Fbs.wikipedia.org%3AEnzim+razgradnje+glikogenskih+grana" class="Z3988"></span></span> </li> <li id="cite_note-Song-5"><span class="mw-cite-backlink">^ <a href="#cite_ref-Song_5-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Song_5-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-Song_5-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r3303350"><cite class="citation journal cs1">Song HN, Jung TY, Park JT, Park BC, Myung PK, Boos W, Woo EJ, Park KH (juni 2010). "Structural rationale for the short branched substrate specificity of the glycogen debranching enzyme GlgX". <i>Proteins</i>. <b>78</b> (8): 1847–55. <a href="/wiki/Doi_(identifikator)" class="mw-redirect" title="Doi (identifikator)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fprot.22697">10.1002/prot.22697</a>. <a href="/wiki/PMID_(identifikator)" class="mw-redirect" title="PMID (identifikator)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/20187119">20187119</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Proteins&rft.atitle=Structural+rationale+for+the+short+branched+substrate+specificity+of+the+glycogen+debranching+enzyme+GlgX&rft.volume=78&rft.issue=8&rft.pages=1847-55&rft.date=2010-06&rft_id=info%3Adoi%2F10.1002%2Fprot.22697&rft_id=info%3Apmid%2F20187119&rfr_id=info%3Asid%2Fbs.wikipedia.org%3AEnzim+razgradnje+glikogenskih+grana" class="Z3988"></span><span class="cs1-maint citation-comment">CS1 održavanje: upotreba parametra authors (<a href="/wiki/Kategorija:CS1_odr%C5%BEavanje:_upotreba_parametra_authors" title="Kategorija:CS1 održavanje: upotreba parametra authors">link</a>)</span></span> </li> <li id="cite_note-Bao-6"><span class="mw-cite-backlink"><b><a href="#cite_ref-Bao_6-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r3303350"><cite class="citation journal cs1">Bao Y, Dawson TL, Chen YT (decembar 1996). "Human glycogen debranching enzyme gene (AGL): complete structural organization and characterization of the 5' flanking region". <i>Genomics</i>. <b>38</b> (2): 155–65. <a href="/wiki/Doi_(identifikator)" class="mw-redirect" title="Doi (identifikator)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1006%2Fgeno.1996.0611">10.1006/geno.1996.0611</a>. <a href="/wiki/PMID_(identifikator)" class="mw-redirect" title="PMID (identifikator)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/8954797">8954797</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Genomics&rft.atitle=Human+glycogen+debranching+enzyme+gene+%28AGL%29%3A+complete+structural+organization+and+characterization+of+the+5%27+flanking+region&rft.volume=38&rft.issue=2&rft.pages=155-65&rft.date=1996-12&rft_id=info%3Adoi%2F10.1006%2Fgeno.1996.0611&rft_id=info%3Apmid%2F8954797&rfr_id=info%3Asid%2Fbs.wikipedia.org%3AEnzim+razgradnje+glikogenskih+grana" class="Z3988"></span><span class="cs1-maint citation-comment">CS1 održavanje: upotreba parametra authors (<a href="/wiki/Kategorija:CS1_odr%C5%BEavanje:_upotreba_parametra_authors" title="Kategorija:CS1 održavanje: upotreba parametra authors">link</a>)</span></span> </li> <li id="cite_note-Chen-7"><span class="mw-cite-backlink"><b><a href="#cite_ref-Chen_7-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r3303350"><cite class="citation journal cs1">Chen YT, He JK, Ding JH, Brown BI (decembar 1987). <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC1684360">"Glycogen debranching enzyme: purification, antibody characterization, and immunoblot analyses of type III glycogen storage disease"</a>. <i>Am. J. Hum. Genet</i>. <b>41</b> (6): 1002–15. <a href="/wiki/PMC_(identifikator)" class="mw-redirect" title="PMC (identifikator)">PMC</a> <span class="cs1-lock-free" title="Slobodno dostupno"><a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC1684360">1684360</a></span>. <a href="/wiki/PMID_(identifikator)" class="mw-redirect" title="PMID (identifikator)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/2961257">2961257</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Am.+J.+Hum.+Genet.&rft.atitle=Glycogen+debranching+enzyme%3A+purification%2C+antibody+characterization%2C+and+immunoblot+analyses+of+type+III+glycogen+storage+disease&rft.volume=41&rft.issue=6&rft.pages=1002-15&rft.date=1987-12&rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1684360%23id-name%3DPMC&rft_id=info%3Apmid%2F2961257&rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1684360&rfr_id=info%3Asid%2Fbs.wikipedia.org%3AEnzim+razgradnje+glikogenskih+grana" class="Z3988"></span><span class="cs1-maint citation-comment">CS1 održavanje: upotreba parametra authors (<a href="/wiki/Kategorija:CS1_odr%C5%BEavanje:_upotreba_parametra_authors" title="Kategorija:CS1 održavanje: upotreba parametra authors">link</a>)</span></span> </li> <li id="cite_note-UniProt_P35573-8"><span class="mw-cite-backlink"><b><a href="#cite_ref-UniProt_P35573_8-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r3303350"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.uniprot.org/uniprot/P35573">"Glycogen debranching enzyme - Homo sapiens (Human)"</a>. UniProt.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Glycogen+debranching+enzyme+-+Homo+sapiens+%28Human%29&rft.pub=UniProt&rft_id=http%3A%2F%2Fwww.uniprot.org%2Funiprot%2FP35573&rfr_id=info%3Asid%2Fbs.wikipedia.org%3AEnzim+razgradnje+glikogenskih+grana" class="Z3988"></span></span> </li> <li id="cite_note-Gillard_80-9"><span class="mw-cite-backlink"><b><a href="#cite_ref-Gillard_80_9-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r3303350"><cite class="citation journal cs1">Gillard BK, White RC, Zingaro RA, Nelson TE (septembar 1980). "Amylo-1,6-glucosidase/4-alpha-glucanotransferase. Reaction of rabbit muscle debranching enzyme with an active site-directed irreversible inhibitor, 1-S-dimethylarsino-1-thio-beta-D-glucopyranoside". <i>J. Biol. Chem</i>. <b>255</b> (18): 8451–7. <a href="/wiki/PMID_(identifikator)" class="mw-redirect" title="PMID (identifikator)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/6447697">6447697</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Biol.+Chem.&rft.atitle=Amylo-1%2C6-glucosidase%2F4-alpha-glucanotransferase.+Reaction+of+rabbit+muscle+debranching+enzyme+with+an+active+site-directed+irreversible+inhibitor%2C+1-S-dimethylarsino-1-thio-beta-D-glucopyranoside&rft.volume=255&rft.issue=18&rft.pages=8451-7&rft.date=1980-09&rft_id=info%3Apmid%2F6447697&rfr_id=info%3Asid%2Fbs.wikipedia.org%3AEnzim+razgradnje+glikogenskih+grana" class="Z3988"></span><span class="cs1-maint citation-comment">CS1 održavanje: upotreba parametra authors (<a href="/wiki/Kategorija:CS1_odr%C5%BEavanje:_upotreba_parametra_authors" title="Kategorija:CS1 održavanje: upotreba parametra authors">link</a>)</span></span> </li> <li id="cite_note-Gillard-10"><span class="mw-cite-backlink"><b><a href="#cite_ref-Gillard_10-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r3303350"><cite class="citation journal cs1">Gillard BK, Nelson TE (septembar 1977). 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Biol. Chem</i>. <b>283</b> (42): 28641–8. <a href="/wiki/Doi_(identifikator)" class="mw-redirect" title="Doi (identifikator)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M802560200">10.1074/jbc.M802560200</a>. <a href="/wiki/PMC_(identifikator)" class="mw-redirect" title="PMC (identifikator)">PMC</a> <span class="cs1-lock-free" title="Slobodno dostupno"><a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC2661413">2661413</a></span>. <a href="/wiki/PMID_(identifikator)" class="mw-redirect" title="PMID (identifikator)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/18703518">18703518</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Biol.+Chem.&rft.atitle=Structural+insight+into+the+bifunctional+mechanism+of+the+glycogen-debranching+enzyme+TreX+from+the+archaeon+Sulfolobus+solfataricus&rft.volume=283&rft.issue=42&rft.pages=28641-8&rft.date=2008-10&rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2661413%23id-name%3DPMC&rft_id=info%3Apmid%2F18703518&rft_id=info%3Adoi%2F10.1074%2Fjbc.M802560200&rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2661413&rfr_id=info%3Asid%2Fbs.wikipedia.org%3AEnzim+razgradnje+glikogenskih+grana" class="Z3988"></span><span class="cs1-maint citation-comment">CS1 održavanje: upotreba parametra authors (<a href="/wiki/Kategorija:CS1_odr%C5%BEavanje:_upotreba_parametra_authors" title="Kategorija:CS1 održavanje: upotreba parametra authors">link</a>)</span></span> </li> <li id="cite_note-UniProt_A8QX06-12"><span class="mw-cite-backlink">^ <a href="#cite_ref-UniProt_A8QX06_12-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-UniProt_A8QX06_12-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r3303350"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.uniprot.org/uniprot/A8QX06">"TreX - Actinoplanes sp. SN223/29"</a>. UniProt.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=TreX+-+Actinoplanes+sp.+SN223%2F29&rft.pub=UniProt&rft_id=http%3A%2F%2Fwww.uniprot.org%2Funiprot%2FA8QX06&rfr_id=info%3Asid%2Fbs.wikipedia.org%3AEnzim+razgradnje+glikogenskih+grana" class="Z3988"></span></span> </li> <li id="cite_note-UniProt_A7ZSW4-13"><span class="mw-cite-backlink"><b><a href="#cite_ref-UniProt_A7ZSW4_13-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r3303350"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.uniprot.org/uniprot/A7ZSW4">"Glycogen debranching enzyme - Escherichia coli O139:H28 (strain E24377A / ETEC)"</a>. UniProt.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Glycogen+debranching+enzyme+-+Escherichia+coli+O139%3AH28+%28strain+E24377A+%2F+ETEC%29&rft.pub=UniProt&rft_id=http%3A%2F%2Fwww.uniprot.org%2Funiprot%2FA7ZSW4&rfr_id=info%3Asid%2Fbs.wikipedia.org%3AEnzim+razgradnje+glikogenskih+grana" class="Z3988"></span></span> </li> <li id="cite_note-UniProt_P15977-14"><span class="mw-cite-backlink"><b><a href="#cite_ref-UniProt_P15977_14-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r3303350"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.uniprot.org/uniprot/P15977">"4-alpha-glucanotransferase - Escherichia coli (strain K12)"</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=4-alpha-glucanotransferase+-+Escherichia+coli+%28strain+K12%29&rft_id=http%3A%2F%2Fwww.uniprot.org%2Funiprot%2FP15977&rfr_id=info%3Asid%2Fbs.wikipedia.org%3AEnzim+razgradnje+glikogenskih+grana" class="Z3988"></span></span> </li> <li id="cite_note-Park-15"><span class="mw-cite-backlink">^ <a href="#cite_ref-Park_15-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Park_15-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r3303350"><cite class="citation journal cs1">Park JT, Park HS, Kang HK, Hong JS, Cha H, Woo EJ, Kim JW, Kim MJ, Boos W, Lee S, Park KH (2008). "Oligomeric and functional properties of a debranching enzyme (TreX) from the archaeon Sulfobus solfataricus P2". <i>Biocatalysis and Biotransformation</i>. <b>26</b>: 76–85. <a href="/wiki/Doi_(identifikator)" class="mw-redirect" title="Doi (identifikator)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1080%2F10242420701806652">10.1080/10242420701806652</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Biocatalysis+and+Biotransformation&rft.atitle=Oligomeric+and+functional+properties+of+a+debranching+enzyme+%28TreX%29+from+the+archaeon+Sulfobus+solfataricus+P2.&rft.volume=26&rft.pages=76-85&rft.date=2008&rft_id=info%3Adoi%2F10.1080%2F10242420701806652&rfr_id=info%3Asid%2Fbs.wikipedia.org%3AEnzim+razgradnje+glikogenskih+grana" class="Z3988"></span><span class="cs1-maint citation-comment">CS1 održavanje: upotreba parametra authors (<a href="/wiki/Kategorija:CS1_odr%C5%BEavanje:_upotreba_parametra_authors" title="Kategorija:CS1 održavanje: upotreba parametra authors">link</a>)</span></span> </li> <li id="cite_note-Talente-16"><span class="mw-cite-backlink"><b><a href="#cite_ref-Talente_16-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r3303350"><cite class="citation journal cs1">Talente GM, Coleman RA, Alter C, Baker L, Brown BI, Cannon RA, Chen YT, Crigler JF, Ferreira P, Haworth JC, Herman GE, Issenman RM, Keating JP, Linde R, Roe TF, Senior B, Wolfsdorf JI (februar 1994). 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Med</i>. <b>120</b> (3): 218–26. <a href="/wiki/Doi_(identifikator)" class="mw-redirect" title="Doi (identifikator)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.7326%2F0003-4819-120-3-199402010-00008">10.7326/0003-4819-120-3-199402010-00008</a>. <a href="/wiki/PMID_(identifikator)" class="mw-redirect" title="PMID (identifikator)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/8273986">8273986</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Ann.+Intern.+Med.&rft.atitle=Glycogen+storage+disease+in+adults&rft.volume=120&rft.issue=3&rft.pages=218-26&rft.date=1994-02&rft_id=info%3Adoi%2F10.7326%2F0003-4819-120-3-199402010-00008&rft_id=info%3Apmid%2F8273986&rfr_id=info%3Asid%2Fbs.wikipedia.org%3AEnzim+razgradnje+glikogenskih+grana" class="Z3988"></span><span class="cs1-maint citation-comment">CS1 održavanje: upotreba parametra authors (<a href="/wiki/Kategorija:CS1_odr%C5%BEavanje:_upotreba_parametra_authors" title="Kategorija:CS1 održavanje: upotreba parametra authors">link</a>)</span></span> </li> <li id="cite_note-Monga-17"><span class="mw-cite-backlink"><b><a href="#cite_ref-Monga_17-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r3303350"><cite id="CITEREFSatdarshan_P._S._Monga2010" class="citation book cs1">Satdarshan P. S. Monga (2010). <i>Molecular Pathology of Liver Diseases (Molecular Pathology Library)</i>. Berlin: Springer. <a href="/wiki/ISBN_(identifikator)" class="mw-redirect" title="ISBN (identifikator)">ISBN</a> <a href="/wiki/Posebno:Knji%C5%BEni_izvori/1-4419-7106-8" title="Posebno:Knjižni izvori/1-4419-7106-8"><bdi>1-4419-7106-8</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Molecular+Pathology+of+Liver+Diseases+%28Molecular+Pathology+Library%29&rft.place=Berlin&rft.pub=Springer&rft.date=2010&rft.isbn=1-4419-7106-8&rft.au=Satdarshan+P.+S.+Monga&rfr_id=info%3Asid%2Fbs.wikipedia.org%3AEnzim+razgradnje+glikogenskih+grana" class="Z3988"></span></span> </li> <li id="cite_note-Hondoh-18"><span class="mw-cite-backlink"><b><a href="#cite_ref-Hondoh_18-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r3303350"><cite class="citation journal cs1">Hondoh H, Saburi W, Mori H et al. (maj 2008). "Substrate recognition mechanism of alpha-1,6-glucosidic linkage hydrolyzing enzyme, dextran glucosidase from Streptococcus mutans". <i>J. Mol. Biol</i>. <b>378</b> (4): 913–22. <a href="/wiki/Doi_(identifikator)" class="mw-redirect" title="Doi (identifikator)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.jmb.2008.03.016">10.1016/j.jmb.2008.03.016</a>. <a href="/wiki/PMID_(identifikator)" class="mw-redirect" title="PMID (identifikator)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/18395742">18395742</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Mol.+Biol.&rft.atitle=Substrate+recognition+mechanism+of+alpha-1%2C6-glucosidic+linkage+hydrolyzing+enzyme%2C+dextran+glucosidase+from+Streptococcus+mutans&rft.volume=378&rft.issue=4&rft.pages=913-22&rft.date=2008-05&rft_id=info%3Adoi%2F10.1016%2Fj.jmb.2008.03.016&rft_id=info%3Apmid%2F18395742&rfr_id=info%3Asid%2Fbs.wikipedia.org%3AEnzim+razgradnje+glikogenskih+grana" class="Z3988"></span> <span class="cs1-visible-error error citation-comment"><span class="cs1-visible-error error citation-comment">Eksplicitna upotreba et al. u: <code class="cs1-code">|authors=</code> (<a href="/w/index.php?title=Pomo%C4%87:CS1_gre%C5%A1ke&action=edit&redlink=1" class="new" title="Pomoć:CS1 greške (stranica ne postoji)">pomoć</a>)</span></span><span class="cs1-maint citation-comment">CS1 održavanje: upotreba parametra authors (<a href="/wiki/Kategorija:CS1_odr%C5%BEavanje:_upotreba_parametra_authors" title="Kategorija:CS1 održavanje: upotreba parametra authors">link</a>)</span></span> </li> <li id="cite_note-MCCarter-19"><span class="mw-cite-backlink"><b><a href="#cite_ref-MCCarter_19-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r3303350"><cite class="citation journal cs1">McCarter JD, Withers SG (decembar 1994). "Mechanisms of enzymatic glycoside hydrolysis". <i>Curr. Opin. Struct. Biol</i>. <b>4</b> (6): 885–92. <a href="/wiki/Doi_(identifikator)" class="mw-redirect" title="Doi (identifikator)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0959-440X%2894%2990271-2">10.1016/0959-440X(94)90271-2</a>. <a href="/wiki/PMID_(identifikator)" class="mw-redirect" title="PMID (identifikator)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/7712292">7712292</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Curr.+Opin.+Struct.+Biol.&rft.atitle=Mechanisms+of+enzymatic+glycoside+hydrolysis&rft.volume=4&rft.issue=6&rft.pages=885-92&rft.date=1994-12&rft_id=info%3Adoi%2F10.1016%2F0959-440X%2894%2990271-2&rft_id=info%3Apmid%2F7712292&rfr_id=info%3Asid%2Fbs.wikipedia.org%3AEnzim+razgradnje+glikogenskih+grana" class="Z3988"></span><span class="cs1-maint citation-comment">CS1 održavanje: upotreba parametra authors (<a href="/wiki/Kategorija:CS1_odr%C5%BEavanje:_upotreba_parametra_authors" title="Kategorija:CS1 održavanje: upotreba parametra authors">link</a>)</span></span> </li> <li id="cite_note-Yamamoto-20"><span class="mw-cite-backlink"><b><a href="#cite_ref-Yamamoto_20-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r3303350"><cite class="citation journal cs1">Yamamoto E, Makino Y, Omichi K (maj 2007). "Active site mapping of amylo-alpha-1,6-glucosidase in porcine liver glycogen debranching enzyme using fluorogenic 6-O-alpha-glucosyl-maltooligosaccharides". <i>J. Biochem</i>. <b>141</b> (5): 627–34. <a href="/wiki/Doi_(identifikator)" class="mw-redirect" title="Doi (identifikator)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fjb%2Fmvm065">10.1093/jb/mvm065</a>. <a href="/wiki/PMID_(identifikator)" class="mw-redirect" title="PMID (identifikator)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/17317688">17317688</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Biochem.&rft.atitle=Active+site+mapping+of+amylo-alpha-1%2C6-glucosidase+in+porcine+liver+glycogen+debranching+enzyme+using+fluorogenic+6-O-alpha-glucosyl-maltooligosaccharides&rft.volume=141&rft.issue=5&rft.pages=627-34&rft.date=2007-05&rft_id=info%3Adoi%2F10.1093%2Fjb%2Fmvm065&rft_id=info%3Apmid%2F17317688&rfr_id=info%3Asid%2Fbs.wikipedia.org%3AEnzim+razgradnje+glikogenskih+grana" class="Z3988"></span><span class="cs1-maint citation-comment">CS1 održavanje: upotreba parametra authors (<a href="/wiki/Kategorija:CS1_odr%C5%BEavanje:_upotreba_parametra_authors" title="Kategorija:CS1 održavanje: upotreba parametra authors">link</a>)</span></span> </li> <li id="cite_note-Molecule-21"><span class="mw-cite-backlink"><b><a href="#cite_ref-Molecule_21-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r3303350"><cite id="CITEREFChiba_S1997" class="citation journal cs1">Chiba S (august 1997). 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Biochem</i>. <b>61</b> (8): 1233–9. <a href="/wiki/Doi_(identifikator)" class="mw-redirect" title="Doi (identifikator)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1271%2Fbbb.61.1233">10.1271/bbb.61.1233</a>. <a href="/wiki/PMID_(identifikator)" class="mw-redirect" title="PMID (identifikator)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/9301101">9301101</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Biosci.+Biotechnol.+Biochem.&rft.atitle=Molecular+mechanism+in+alpha-glucosidase+and+glucoamylase&rft.volume=61&rft.issue=8&rft.pages=1233-9&rft.date=1997-08&rft_id=info%3Adoi%2F10.1271%2Fbbb.61.1233&rft_id=info%3Apmid%2F9301101&rft.au=Chiba+S&rfr_id=info%3Asid%2Fbs.wikipedia.org%3AEnzim+razgradnje+glikogenskih+grana" class="Z3988"></span></span> </li> <li id="cite_note-Gene-22"><span class="mw-cite-backlink"><b><a href="#cite_ref-Gene_22-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r3303350"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://ghr.nlm.nih.gov/gene/AGL">"Genes (Genetic Home Reference a service of U.S. National Library of Medicine"</a><span class="reference-accessdate">. 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(juli 2010). "Glycogen storage disease type III diagnosis and management guidelines". <i>Genet. Med</i>. <b>12</b> (7): 446–63. <a href="/wiki/Doi_(identifikator)" class="mw-redirect" title="Doi (identifikator)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1097%2FGIM.0b013e3181e655b6">10.1097/GIM.0b013e3181e655b6</a>. <a href="/wiki/PMID_(identifikator)" class="mw-redirect" title="PMID (identifikator)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/20631546">20631546</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Genet.+Med.&rft.atitle=Glycogen+storage+disease+type+III+diagnosis+and+management+guidelines&rft.volume=12&rft.issue=7&rft.pages=446-63&rft.date=2010-07&rft_id=info%3Adoi%2F10.1097%2FGIM.0b013e3181e655b6&rft_id=info%3Apmid%2F20631546&rfr_id=info%3Asid%2Fbs.wikipedia.org%3AEnzim+razgradnje+glikogenskih+grana" class="Z3988"></span> <span class="cs1-visible-error error citation-comment"><span class="cs1-visible-error error citation-comment">Eksplicitna upotreba et al. u: <code class="cs1-code">|authors=</code> (<a href="/w/index.php?title=Pomo%C4%87:CS1_gre%C5%A1ke&action=edit&redlink=1" class="new" title="Pomoć:CS1 greške (stranica ne postoji)">pomoć</a>)</span></span><span class="cs1-maint citation-comment">CS1 održavanje: upotreba parametra authors (<a href="/wiki/Kategorija:CS1_odr%C5%BEavanje:_upotreba_parametra_authors" title="Kategorija:CS1 održavanje: upotreba parametra authors">link</a>)</span></span> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="Vanjski_linovi">Vanjski linovi</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Enzim_razgradnje_glikogenskih_grana&veaction=edit&section=7" title="Uredi odlomak "Vanjski linovi"" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Enzim_razgradnje_glikogenskih_grana&action=edit&section=7" title="Edit section's source code: Vanjski linovi"><span>uredi izvor</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=gsd3">GeneReviews/NCBI/NIH/UW entry on Glycogen Storage Disease Type III</a></li> <li><a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/omim/232400,610860,232400,610860">OMIM entries on Glycogen Storage Disease Type III</a></li> <li><a rel="nofollow" class="external text" href="http://www.reactome.org/cgi-bin/link?SOURCE=Reactome&ID=REACT_2106">reactome.org: <i>Debranching enzyme transfers 3-glucose blocks from branches in limit dextrin</i></a><sup class="noprint Inline-Template"><span style="white-space: nowrap;">[<i><a href="/wiki/Wikipedia:Mrtav_link" title="Wikipedia:Mrtav link"><span title=" Mrtav link od datuma Oktobar 2019">mrtav link</span></a></i>]</span></sup></li> <li><a rel="nofollow" class="external text" href="http://www.reactome.org/cgi-bin/link?SOURCE=Reactome&ID=REACT_694">reactome.org: <i>(1,6)-alpha-glucose residues are removed, as D-glucose, from limit dextrin by debranching enzyme</i></a><sup class="noprint Inline-Template"><span style="white-space: nowrap;">[<i><a href="/wiki/Wikipedia:Mrtav_link" title="Wikipedia:Mrtav link"><span title=" Mrtav link od datuma Oktobar 2019">mrtav link</span></a></i>]</span></sup></li> <li><a rel="nofollow" class="external text" href="//www.nlm.nih.gov/cgi/mesh/2011/MB_cgi?mode=&term=Glycogen+debranching+enzyme">Glycogen debranching enzyme</a> na <i>US National Library of Medicine</i> <a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">Medical Subject Headings</a> (MeSH)</li></ul> <p><br /> </p> <style data-mw-deduplicate="TemplateStyles:r3627399">.mw-parser-output .side-box{margin:4px 0;box-sizing:border-box;border:1px solid #aaa;font-size:88%;line-height:1.25em;background-color:#f9f9f9;display:flow-root}.mw-parser-output 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