Search results for: E. Bal Beşikçi

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Bal Beşikçi</title> <meta name="description" content="Search results for: E. Bal Beşikçi"> <meta name="keywords" content="E. Bal Beşikçi"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" type="button" data-toggle="collapse" data-target="#navbarMenu" aria-controls="navbarMenu" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button> <div class="w-100"> <div class="d-none d-lg-flex flex-row-reverse"> <form method="get" action="https://waset.org/search" class="form-inline my-2 my-lg-0"> <input class="form-control mr-sm-2" type="search" placeholder="Search Conferences" value="E. 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Bal Beşikçi"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 3</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: E. Bal Beşikçi</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> Synthesis of Some 1h-Benzimidazoles as Inhibitors of EGFR Tyrosine Kinase</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=I%CC%87smail%20%C3%87eli%CC%87k">İsmail Çeli̇k</a>, <a href="https://publications.waset.org/abstracts/search?q=G%C3%BClg%C3%BCn%20Ayhan-K%C4%B1lc%C4%B1gi%CC%87l"> Gülgün Ayhan-Kılcıgi̇l</a>, <a href="https://publications.waset.org/abstracts/search?q=Arzu%20Onay-Be%C5%9Fi%CC%87k%C3%A7i%CC%87"> Arzu Onay-Beşi̇kçi̇</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this study, some 2-(2-phenyl/substitutedphenyl)- lH-benzo[d]'imidazol-l-yl)-N'-(alkylthiosemicarbazide were designed and prepared. Firstly, 2-phenyl/ suhstitutedphenyl-lH-Benzo[d]imidazole was prepared via oxidative condensation of o-phenylenediamine, benzaldehyde and sodium metabisulfite. Treatment of the benzimidazole compound with ethyl chloroacetate in KOH/DMSO gave the ester compound ethyl 2-(2-substitutedphenyl)-1H-benzo[d]imidazol-l-yl)acetate. Hydrazine hydrate and the ester in ethanol were refluxed for 4 h to give 2-(2-phenyl/substitutedphenyl)-1H-benzo[d]imidazol-l-yl)acetohydrazide. Thiosemicarbazides were obtained by condensing acyl hydrazide with the alkylisothiocyanate in ethanol. Following the structure elucidation, benzimidazole compounds were tested for their EGFR kinase inhibitory activities by using ADP-GloTM Kinase Assay. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=benzimidazole" title="benzimidazole">benzimidazole</a>, <a href="https://publications.waset.org/abstracts/search?q=EGFR%20kinase%20inhibitor" title=" EGFR kinase inhibitor"> EGFR kinase inhibitor</a>, <a href="https://publications.waset.org/abstracts/search?q=synthesis" title=" synthesis"> synthesis</a>, <a href="https://publications.waset.org/abstracts/search?q=thiosemicarbazide" title=" thiosemicarbazide"> thiosemicarbazide</a> </p> <a href="https://publications.waset.org/abstracts/50028/synthesis-of-some-1h-benzimidazoles-as-inhibitors-of-egfr-tyrosine-kinase" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/50028.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">257</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Correlation between Fuel Consumption and Voyage Related Ship Operational Energy Efficiency Measures: An Analysis from Noon Data</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=E.%20Bal%20Be%C5%9Fik%C3%A7i">E. Bal Beşikçi</a>, <a href="https://publications.waset.org/abstracts/search?q=O.%20Arslan"> O. Arslan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Fuel saving has become one of the most important issue for shipping in terms of fuel economy and environmental impact. Lowering fuel consumption is possible for both new ships and existing ships through enhanced energy efficiency measures, technical and operational respectively. The limitations of applying technical measures due to the long payback duration raise the potential of operational changes for energy efficient ship operations. This study identifies operational energy efficiency measures related voyage performance management. We use ‘noon’ data to examine the correlation between fuel consumption and operational parameters- revolutions per minute (RPM), draft, trim, (beaufort number) BN and relative wind direction, which are used as measures of ship energy efficiency. The results of this study reveal that speed optimization is the most efficient method as fuel consumption depends heavily on RPM. In conclusion, this study will provide ship operators with the strategic approach for evaluating the priority of the operational energy efficiency measures against high fuel prices and carbon emissions. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=ship" title="ship">ship</a>, <a href="https://publications.waset.org/abstracts/search?q=voyage%20related%20operational%20energy%20Efficiency%20measures" title=" voyage related operational energy Efficiency measures"> voyage related operational energy Efficiency measures</a>, <a href="https://publications.waset.org/abstracts/search?q=fuel%20consumption" title=" fuel consumption"> fuel consumption</a>, <a href="https://publications.waset.org/abstracts/search?q=pearson%27s%20correlation%20coef%EF%AC%81cient" title=" pearson's correlation coefﬁcient "> pearson's correlation coefﬁcient </a> </p> <a href="https://publications.waset.org/abstracts/25303/correlation-between-fuel-consumption-and-voyage-related-ship-operational-energy-efficiency-measures-an-analysis-from-noon-data" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/25303.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">616</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Design and Synthesis of Some Oxadiazole Bearing Benzimidazole Derivatives as Potential Epidermal Growth Factor Receptor Inhibitors</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ismail%20Celik">Ismail Celik</a>, <a href="https://publications.waset.org/abstracts/search?q=Gulgun%20Ayhan%20Kilcigil"> Gulgun Ayhan Kilcigil</a>, <a href="https://publications.waset.org/abstracts/search?q=Berna%20Guven"> Berna Guven</a>, <a href="https://publications.waset.org/abstracts/search?q=Zumra%20Kara"> Zumra Kara</a>, <a href="https://publications.waset.org/abstracts/search?q=Arzu%20Onay-Besikci"> Arzu Onay-Besikci</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Epidermal Growth Factor Receptor is the cell-surface receptor of the ErbB (erythroblastic leukemia viral oncogene homologue receptors) family of tyrosine kinases. It plays a vital role in regulating the proliferation and differentiation of cells. However, a variety of mechanisms, such as EGFR expression, mutation, and ligand-dependent receptor dimerization, are associated with the development of various activated EGFR tumors. EGFR is highly expressed in most solid tumors, including breast, head and neck cancer, non-small cell lung cancer (NSCLC), renal, ovarian, and colon cancers. Thus, specific EGFR inhibition plays one of the key roles in cancer treatment. The compounds used in the treatment as tyrosine kinase inhibitors are known to contain the benzimidazole isosterium indole, pazopanib, and axitinibin indazole rings. In addition, benzimidazoles have been shown to exhibit protein kinase inhibitory activity in addition to their different biological activities.Based on these data, it was planned and synthesized of some oxadiazole bearing benzimidazole derivatives [N-cyclohexyl-5-((2-phenyl/substitutedphenyl-1H-benzo[d]imidazole-1-yl) methyl)-1,3,4-oxadiazole-2-amine]. EGFR kinase inhibitory efficiency of the synthesized compounds was determined by comparing them with a known kinase inhibitor erlotinib in vitro, and two of the compounds bearing phenyl (19a) and 3,4-dibenzyloxyphenyl (21a) ring exhibited significant activities. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=benzimidazole" title="benzimidazole">benzimidazole</a>, <a href="https://publications.waset.org/abstracts/search?q=EGFR%20kinase%20inhibitory" title=" EGFR kinase inhibitory"> EGFR kinase inhibitory</a>, <a href="https://publications.waset.org/abstracts/search?q=oxadiazole" title=" oxadiazole"> oxadiazole</a>, <a href="https://publications.waset.org/abstracts/search?q=synthesis" title=" synthesis"> synthesis</a> </p> <a href="https://publications.waset.org/abstracts/108680/design-and-synthesis-of-some-oxadiazole-bearing-benzimidazole-derivatives-as-potential-epidermal-growth-factor-receptor-inhibitors" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/108680.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">139</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational anniversary</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Account <li><a href="https://waset.org/profile">My Account</a></li> </ul> </div> <div class="col-md-2"> 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Search results for: E. Bal Beşikçi