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RCA is committed to providing a platform for discovery of high-quality articles, journals, scholars, and academic assistants by biomedical researchers, universities, hospitals, research institutions, funding agencies, librarians, publishers, and journal editors worldwide." /> </head> <body> <form method="post" action="./search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAP+Kinase+Signaling+System%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" id="form1"> <div class="aspNetHidden"> <input type="hidden" name="__EVENTTARGET" id="__EVENTTARGET" value="" /> <input type="hidden" name="__EVENTARGUMENT" id="__EVENTARGUMENT" value="" /> <input type="hidden" name="__VIEWSTATE" id="__VIEWSTATE" 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name="ctl00$RootHolder$RCAUserType" id="RCAUserType" /> <input type="hidden" name="ctl00$RootHolder$UserId" id="UserId" /> <input type="hidden" name="ctl00$RootHolder$IsCurrentUser" id="IsCurrentUser" /> <div class="search-result-container cl"> <div class="search-centered cl"> <div class="search-result-center-container cl"> <div class="left-part"> <div id="RootHolder_ExportContainer" class="export-container"> <div class="dxbButton_MetropolisBlue DefaultButton-Oral dxbButtonSys dxbTSys" id="RootHolder_DownloadArticle" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_DownloadArticle_I" class="dxb-hb" value="Download" type="button" name="ctl00$RootHolder$DownloadArticle" /><span class="dx-vam">Download</span> </div> </div><script id="dxss_1963926087" type="text/javascript">  </script> </div> <div class="mnavbar"> <table class="total-count-container cl"> <tr> <td> <a href="/" target="_blank" class="white-link">Total Articles</a> </td> </tr> </table> </div> <div class="mnavbox"> <label id="RootHolder_TotalCountText" class="total-count-text">494</label> <br /> <label style="font-size: 14px;">(from Reference Citation Analysis)</label> <div id="RootHolder_SearchArticlePDFContainer" style="padding-top: 1rem;"> <input name="ctl00$RootHolder$ArticlesWithPdf" type="checkbox" id="RootHolder_ArticlesWithPdf" class="ArticlesWithPdf" onclick="SearchArticleWithPDF();" /> <label for="ArticlesWithPdf">Article PDFs (49)</label> </div> <div id="RootHolder_SearchTCContainer" style="padding-top: 1rem;"> <input name="ctl00$RootHolder$ArticlesWithTC" type="checkbox" id="RootHolder_ArticlesWithTC" class="ArticlesWithTC" onclick="SearchArticleWithTC();" /> <label for="ArticlesWithTC">Cited by ≥ 1 (399)</label> </div> </div> <div class="mnavbar" id="SearchedNameTitle"> <div> Searched Name </div> </div> <div class="mnavbox" id="SearchedNameText"> <label id="RootHolder_SearchTermText" class="search-term-text">MAP Kinase 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id="PubDateFacetContainer"> <ul class="ul sortedby-list"> <li> <a href="javascript:SubmitSingleFacetSearch('create','6');">Today (<span id="indexCount6"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','5');">Yesterday (<span id="indexCount5"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','4');">This Week (<span id="indexCount4"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','3');">Last Week (<span id="indexCount3"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','2');">Current Month (<span id="indexCount2"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','1');">Last Month (<span id="indexCount1"></span>)</a> </li> </ul> </div> <div id="journalFacetContainer"> <div class="mnavbar"> <div> Publication Titles </div> </div> <div class="mnavbox"> <div id="journalFacetItemContainer"> </div> <div class="refine-btn-container cl"> <a href="javascript:ShowResultItems('journal');" class="refine-link-btn" target="_self">Show more</a>   <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refinejournalcheck" target="_self">Refine</a> </div> </div> </div> <div id="fundFacetContainer"> <div class="mnavbar"> <div> Grant Agencies </div> </div> <div class="mnavbox"> <div id="fundFacetItemContainer"> </div> <div class="refine-btn-container cl"> <a href="javascript:ShowResultItems('fund');" class="refine-link-btn" target="_self">Show more</a>   <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refinefundcheck" target="_self">Refine</a> </div> </div> </div> <div id="subjectFacetContainer"> <div class="mnavbar"> <div> Category </div> </div> <div class="mnavbox"> <div id="subjectFacetItemContainer"> </div> <div class="refine-btn-container cl"> <a href="javascript:ShowResultItems('subject');" class="refine-link-btn" target="_self">Show more</a>   <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refinesubjectcheck" target="_self">Refine</a> </div> </div> </div> </div> </div> <div class="right-part"> <div class="mnavbar" style="margin-bottom: 0.625rem;"> <div> Journal Articles </div> </div> <table class="article-result-list cl"> <thead> <tr> <td> <span class="dxeBase_MetropolisBlue" id="RootHolder_SearchResultList_NumberTitle">Number</span> </td> <td> <span class="dxeBase_MetropolisBlue" id="RootHolder_SearchResultList_NameTitle">Citation Analysis</span> </td> </tr> </thead> <tbody> <tr id="articlerow1"> <td style="min-width: 40px; text-align: center;"> 1 </td> <td> <div id="citation1" class="article-citation"> <b>Pushpamithran G</b>, Blomgran R. Macrophage-derived extracellular vesicles from <i>Ascaris lumbricoides</i> antigen exposure enhance <i>Mycobacterium tuberculosis</i> growth control, reduce IL-1β, and contain miR-342-5p, miR-516b-5p, and miR-570-3p that regulate PI3K/AKT and MAPK signaling pathways. <em class='incite-journal-name' onclick='ShowInCiteJournal(9345);'>Front Immunol</em> 2024;<b>15</b>:1454881. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39569198' target='_blank'>39569198</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11576181' target='_blank'>PMC11576181</a> DOI: <a href='https://dx.doi.org/10.3389/fimmu.2024.1454881' target='_blank'>10.3389/fimmu.2024.1454881</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3389/fimmu.2024.1454881','39569198', 'MAP Kinase Signaling System/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(1);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(1);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(1);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3389/fimmu.2024.1454881' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.3389/fimmu.2024.1454881');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9345);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/22/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv1" value="10.3389/fimmu.2024.1454881" /> <div style="display: none" id="articleAbstract1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">Background</div><div class="abstract-content">Helminth coinfection with tuberculosis (TB) can alter the phenotype and function of macrophages, which are the major host cells responsible for controlling Mycobacterium tuberculosis (Mtb). However, it is not known whether helminth infection stimulates the release of host-derived extracellular vesicles (EVs) to induce or maintain their regulatory network that suppresses TB immunity. We previously showed that pre-exposure of human monocyte-derived macrophages (hMDMs) with Ascaris lumbricoides protein antigens (ASC) results in reduced Mtb infection-driven proinflammation and gained bacterial control. This effect was entirely dependent on the presence of soluble components in the conditioned medium from helminth antigen-pre-exposed macrophages. </div><div class="abstract-label">Methods</div><div class="abstract-content">Our objective was to investigate the role of EVs released from helminth antigen-exposed hMDMs on Mtb-induced proinflammation and its effect on Mtb growth in hMDMs. Conditioned medium from 48-h pre-exposure with ASC or Schistosoma mansoni antigen (SM) was used to isolate EVs by ultracentrifugation. EVs were characterized by immunoblotting, flow cytometry, nanoparticle tracking assay, transmission electron microscopy, and a total of 377 microRNA (miRNA) from EVs screened by TaqMan array. Luciferase-expressing Mtb H37Rv was used to evaluate the impact of isolated EVs on Mtb growth control in hMDMs. </div><div class="abstract-label">Results</div><div class="abstract-content">EV characterization confirmed double-membraned EVs, with a mean size of 140 nm, expressing the classical exosome markers CD63, CD81, CD9, and flotillin-1. Specifically, EVs from the ASC conditioned medium increased the bacterial control in treatment-naïve hMDMs and attenuated Mtb-induced IL-1β at 5 days post-infection. Four miRNAs showed unique upregulation in response to ASC exposure in five donors. Pathway enrichment analysis showed that the MAPK and PI3K-AKT signaling pathways were regulated. Among the mRNA targets, relevant for regulating inflammatory responses and cellular stress pathways, CREB1 and MAPK13 were identified. In contrast, SM exposure showed significant regulation of the TGF-β signaling pathway with SMAD4 as a common target. </div><div class="abstract-label">Conclusion</div><div class="abstract-content">Overall, our findings suggest that miRNAs in EVs released from helminth-exposed macrophages regulate important signaling pathways that influence macrophage control of Mtb and reduce inflammation. Understanding these interactions between helminth-induced EVs, miRNAs, and macrophage responses may inform novel therapeutic strategies for TB management. </div> <a href="javascript:ShowArticleAbstract(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CREB1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CREB1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAPK13%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAPK13</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SMAD4%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SMAD4</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22helminth-coinfection%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">helminth-coinfection</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22macrophage+extracellular+vesicles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">macrophage extracellular vesicles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22miRNA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">miRNA</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22tuberculosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">tuberculosis</a></li></ul> <a href="javascript:ShowArticleKeywords(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Extracellular+Vesicles%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Extracellular Vesicles/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Extracellular+Vesicles%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Extracellular Vesicles/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antigens%2c+Helminth%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antigens, Helminth/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mycobacterium+tuberculosis%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mycobacterium tuberculosis/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ascaris+lumbricoides%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ascaris lumbricoides/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phosphatidylinositol+3-Kinases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phosphatidylinositol 3-Kinases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Proto-Oncogene+Proteins+c-akt%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Proto-Oncogene Proteins c-akt/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Interleukin-1beta%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Interleukin-1beta/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tuberculosis%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tuberculosis/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tuberculosis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tuberculosis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAP+Kinase+Signaling+System%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAP Kinase Signaling System/immunology</a></li></ul> <a href="javascript:ShowArticleMeSH(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(1);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow2"> <td style="min-width: 40px; text-align: center;"> 2 </td> <td> <div id="citation2" class="article-citation"> <b>Li W</b>, Wang Y, Peng Q, Shi Y, Wan P, Yao Y, Bai T, Ma Y, Shu X, Liu Y, Sun B. SARS-CoV-2 NSP14 induces AP-1 transcriptional activity via its interaction with MEK. <em class='incite-journal-name' onclick='ShowInCiteJournal(17420);'>Mol Immunol</em> 2024;<b>175</b>:1-9. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39265360' target='_blank'>39265360</a> DOI: <a href='https://dx.doi.org/10.1016/j.molimm.2024.09.001' target='_blank'>10.1016/j.molimm.2024.09.001</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.molimm.2024.09.001','39265360', 'MAP Kinase Signaling System/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(2);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(2);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(2);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.molimm.2024.09.001' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17420);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/28/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/14/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv2" value="10.1016/j.molimm.2024.09.001" /> <div style="display: none" id="articleAbstract2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The NSP14 protein of SARS-CoV-2 not only facilitates viral replication but also plays a pivotal role in activating the host immune system by enhancing cytokine production. In this study, we found that NSP14 markedly activated the activator protein 1 (AP-1) pathway by increasing the phosphorylation of ERK (p-ERK), which enters the nucleus and promotes AP-1 transcription. The screening of the main proteins of the ERK pathway revealed that NSP14 could interact with MEK, a kinase of ERK, and increase the level of phosphorylated MEK. The addition of the MEK inhibitor U0126 suppressed the level of p-ERK induced by NSP14 and partly blocked cytokine production, suggesting that NSP14 activates MEK to enhance AP-1 signaling. Further investigation demonstrated that the ExoN domain of NSP14 might be crucial for the interaction and activation of MEK. These results suggest a novel mechanism by which NSP14 of SARS-CoV-2 induces a proinflammatory response in the host. </div> <a href="javascript:ShowArticleAbstract(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22AP-1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">AP-1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NSP14%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NSP14</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RAF%2fMEK%2fERK%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RAF/MEK/ERK</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SARS-CoV-2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SARS-CoV-2</a></li></ul> <a href="javascript:ShowArticleKeywords(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transcription+Factor+AP-1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transcription Factor AP-1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SARS-CoV-2%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SARS-CoV-2/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phosphorylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phosphorylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Coronavirus+Papain-Like+Proteases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Coronavirus Papain-Like Proteases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22HEK293+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HEK293 Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22COVID-19%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">COVID-19/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22COVID-19%2fvirology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">COVID-19/virology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22COVID-19%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">COVID-19/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transcription%2c+Genetic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transcription, Genetic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nitriles%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nitriles/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cytokines%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cytokines/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAP+Kinase+Signaling+System%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAP Kinase Signaling System/immunology</a></li></ul> <a href="javascript:ShowArticleMeSH(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(2);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow3"> <td style="min-width: 40px; text-align: center;"> 3 </td> <td> <div id="citation3" class="article-citation"> <b>Chen C</b>, Wang H, Xu L, Guo Z, Fu M, Xia H, He Q, Zhang R, He J. MAPK signaling pathway induced LOX-1<sup>+</sup> polymorphonuclear myeloid-derived suppressor cells in biliary atresia. <em class='incite-journal-name' onclick='ShowInCiteJournal(6637);'>Clin Immunol</em> 2024;<b>268</b>:110355. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39237078' target='_blank'>39237078</a> DOI: <a href='https://dx.doi.org/10.1016/j.clim.2024.110355' target='_blank'>10.1016/j.clim.2024.110355</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.clim.2024.110355','39237078', 'MAP Kinase Signaling System/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(3);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(3);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(3);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.clim.2024.110355' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(6637);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/28/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/07/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv3" value="10.1016/j.clim.2024.110355" /> <div style="display: none" id="articleAbstract3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Biliary atresia (BA) is a severe pediatric liver disease characterized by progressive bile duct destruction and fibrosis, leading to significant liver damage and frequently necessitating liver transplantation. This study elucidates the role of LOX-1+ polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) in BA pathogenesis and assesses their potential as non-invasive early diagnostic biomarkers. Using flow cytometry, immunofluorescence, and molecular profiling, we analyzed the expression and activity of these cells in peripheral blood and liver tissues from BA patients and controls. Our findings reveal a significant increase in the frequencies and function of LOX-1+PMN-MDSCs in BA patients, along with MAPK signaling pathway upregulation, indicating their involvement in disease mechanisms. Additionally, the frequencies of LOX-1+PMN-MDSC in peripheral blood significantly positively correlate with liver function parameters in BA patients, demonstrating diagnostic performance comparable to traditional serum markers. These findings suggest that LOX-1+PMN-MDSCs contribute to the immunosuppressive environment in BA and could serve as potential diagnostic targets. </div> <a href="javascript:ShowArticleAbstract(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biliary+atresia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biliary atresia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lectin-type+oxidized+LDL+receptor-1+(LOX-1)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lectin-type oxidized LDL receptor-1 (LOX-1)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAPK+signaling+pathway%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAPK signaling pathway</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polymorphonuclear+myeloid-derived+suppressor+cells+(PMN-MDSC)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC)</a></li></ul> <a href="javascript:ShowArticleKeywords(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biliary+Atresia%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biliary Atresia/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biliary+Atresia%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biliary Atresia/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myeloid-Derived+Suppressor+Cells%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myeloid-Derived Suppressor Cells/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myeloid-Derived+Suppressor+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myeloid-Derived Suppressor Cells/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Scavenger+Receptors%2c+Class+E%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Scavenger Receptors, Class E/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Scavenger+Receptors%2c+Class+E%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Scavenger Receptors, Class E/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infant%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infant</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAP+Kinase+Signaling+System%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAP Kinase Signaling System/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomarkers%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomarkers</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%2c+Preschool%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child, Preschool</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neutrophils%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neutrophils/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neutrophils%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neutrophils/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(3);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow4"> <td style="min-width: 40px; text-align: center;"> 4 </td> <td> <div id="citation4" class="article-citation"> <b>Bédard-Matteau J</b>, Soulé A, Liu KY, Fourcade L, Fraser DD, Emad A, Rousseau S. Circulating IL-17F, but not IL-17A, is elevated in severe COVID-19 and leads to an ERK1/2 and p38 MAPK-dependent increase in ICAM-1 cell surface expression and neutrophil adhesion on endothelial cells. <em class='incite-journal-name' onclick='ShowInCiteJournal(9345);'>Front Immunol</em> 2024;<b>15</b>:1452788. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39493750' target='_blank'>39493750</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11527637' target='_blank'>PMC11527637</a> DOI: <a href='https://dx.doi.org/10.3389/fimmu.2024.1452788' target='_blank'>10.3389/fimmu.2024.1452788</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3389/fimmu.2024.1452788','39493750', 'MAP Kinase Signaling System/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(4);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(4);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(4);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(4);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3389/fimmu.2024.1452788' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.3389/fimmu.2024.1452788');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9345);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/05/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv4" value="10.3389/fimmu.2024.1452788" /> <div style="display: none" id="articleAbstract4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">Background</div><div class="abstract-content">Severe COVID-19 is associated with neutrophilic inflammation and immunothrombosis. Several members of the IL-17 cytokine family have been associated with neutrophilic inflammation and activation of the endothelium. Therefore, we investigated whether these cytokines were associated with COVID-19. </div><div class="abstract-label">Methods</div><div class="abstract-content">We investigated the association between COVID-19 and circulating plasma levels of IL-17 cytokine family members in participants to the Biobanque québécoise de la COVID-19 (BQC19), a prospective observational cohort and an independent cohort from Western University (London, Ontario). We measured the in vitro impact of IL-17F on intercellular adhesion molecule 1 (ICAM-1) cell surface expression and neutrophil adhesion on endothelial cells in culture. The contribution of two Mitogen Activated Protein Kinase (MAPK) pathways was determined using small molecule inhibitors PD184352 (a MKK1/MKK2 inhibitor) and BIRB0796 (a p38 MAPK inhibitor). </div><div class="abstract-label">Results</div><div class="abstract-content">We found increased IL-17D and IL-17F plasma levels when comparing SARS-CoV-2-positive vs negative hospitalized participants. Moreover, increased plasma levels of IL-17D, IL-17E and IL-17F were noted when comparing severe versus mild COVID-19. IL-17F, but not IL-17A, was significantly elevated in people with COVID-19 compared to healthy controls and with more severe disease. In vitro work on endothelial cells treated with IL-17F for 24h showed an increase cell surface expression of ICAM-1 accompanied by neutrophil adhesion. The introduction of two MAPK inhibitors significantly reduced the binding of neutrophils while also reducing ICAM-1 expression at the surface level of endothelial cells, but not its intracellular expression. </div><div class="abstract-label">Discussion</div><div class="abstract-content">Overall, these results have identified an association between two cytokines of the IL-17 family (IL-17D and IL-17F) with COVID-19 and disease severity. Considering that IL-17F stimulation promotes neutrophil adhesion to the endothelium in a MAPK-dependent manner, it is attractive to speculate that this pathway may contribute to pathogenic immunothrombosis in concert with other molecular effectors. </div> <a href="javascript:ShowArticleAbstract(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22COVID-19%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">COVID-19</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ICAM-1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ICAM-1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAPK%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAPK</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cytokines%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cytokines</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22endothelial+function%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">endothelial function</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neutrophil+binding%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neutrophil binding</a></li></ul> <a href="javascript:ShowArticleKeywords(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh4" 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Molecule-1/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intercellular+Adhesion+Molecule-1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intercellular Adhesion Molecule-1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22p38+Mitogen-Activated+Protein+Kinases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">p38 Mitogen-Activated Protein Kinases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fonds+de+Recherche+du+Qu%c3%a9bec+-+Sant%c3%a9%5cn%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fonds de Recherche du Québec - Santé </a></li></ul> <a href="javascript:ShowArticleGrant(4);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow5"> <td style="min-width: 40px; text-align: center;"> 5 </td> <td> <div id="citation5" class="article-citation"> <b>Li S</b>, Yao Q, Li J, Yang H, Qian R, Zheng M, Wu N, Jiang H, Li L, Zeng Z. Inhibition of neutrophil swarming by type I interferon promotes intracellular bacterial evasion. <em class='incite-journal-name' onclick='ShowInCiteJournal(17180);'>Nat Commun</em> 2024;<b>15</b>:8663. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39375351' target='_blank'>39375351</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11458870' target='_blank'>PMC11458870</a> DOI: <a href='https://dx.doi.org/10.1038/s41467-024-53060-4' target='_blank'>10.1038/s41467-024-53060-4</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s41467-024-53060-4','39375351', 'MAP Kinase Signaling System/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(5);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(5);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(5);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(5);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1038/s41467-024-53060-4' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17180);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 11/10/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/09/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv5" value="10.1038/s41467-024-53060-4" /> <div style="display: none" id="articleAbstract5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Listeria monocytogenes (LM) possesses the ability to breach multiple barriers and elicit intricate immune responses. However, there remains a lack of explicit understanding regarding how LM evades innate immune surveillance within the body. Here, we utilized liver intravital imaging to elucidate the dynamic process of LM during infection in the liver. We discovered that LM can rapidly escape from Kupffer cells (KCs) through listeriolysin O (LLO) and proliferate within hepatocytes. Upon LM exposure to the hepatic sinusoids, neutrophils rapidly aggregate at the site of infection. Subsequently, LM can induce type I interferon (IFN-I) production primarily in the spleen, which acts systemically on neutrophils to hamper their swarming by deactivating the ERK pathway, thus evading neutrophil-mediated eradication. Furthermore, our findings suggest that virus-induced IFN-I suppresses neutrophil swarming, and COVID-19 patients exhibit impaired neutrophil aggregation function. In conclusion, our findings provide compelling evidence demonstrating that intracellular bacteria represented by LM can hijack host defense mechanisms against viral infections to evade immune surveillance. Additionally, impaired neutrophil swarming caused by IFN-I is one of the significant factors contributing to the increased susceptibility to bacterial infections following viral infections. </div> <a href="javascript:ShowArticleAbstract(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22pathogens%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">pathogens</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22antimicrobial+responses%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">antimicrobial responses</a></li><li><a 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<b>Liu Z</b>, Wang W, Zong Y, Li M, Gao Y, Xin X, Zhu T, Wang L, Song L. Norepinephrine regulates TNF expression via the A1AR-p38 MAPK-Relish pathway in granulocytes of oyster Crassostrea gigas. <em>DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY</em> 2024;<b>159</b>:105217. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38901503' target='_blank'>38901503</a> DOI: <a href='https://dx.doi.org/10.1016/j.dci.2024.105217' target='_blank'>10.1016/j.dci.2024.105217</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.dci.2024.105217','38901503', 'MAP Kinase Signaling System/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(6);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(6);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(6);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.dci.2024.105217' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 06/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/22/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv6" value="10.1016/j.dci.2024.105217" /> <div style="display: none" id="articleAbstract6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Norepinephrine (NE) is involved in regulating cytokine expression and phagocytosis of immune cells in the innate immunity of vertebrates. In the present study, the modulation mechanism of NE on the biosynthesis of TNFs in oyster granulocytes was explored. The transcripts of CgTNF-1, CgTNF-2 and CgTNF-3 were highly expressed in granulocytes, and they were significantly up-regulated after LPS stimulation, while down-regulated after NE treatment. The phagocytic rate and apoptosis index of oyster granulocytes were also triggered by LPS stimulation and suppressed by NE treatment. The mRNA expressions of CgMAPK14 and CgRelish were significantly induced after NE treatment, and the translocation of CgRelish from cytoplasm to nucleus was observed. The concentration of intracellular Ca2+ in granulocytes was significantly up-regulated upon NE incubation, and this trend reverted after the treatment with DOX (specific antagonist for NE receptor, CgA1AR-1). No obvious significance was observed in intracellular cAMP concentrations in the PBS, NE and NE + DOX groups. Once CgA1AR-1 was blocked by DOX, the mRNA expressions of CgMAPK14 and CgRelish were significantly inhibited, and the translocation of CgRelish from cytoplasm to nucleus was also dramatically suppressed, while the mRNA expression of CgTNF-1 and the apoptosis index increased significantly to the same level with those in LPS group, respectively. These results collectively suggested that NE modulated TNF expression in oyster granulocyte through A1AR-p38 MAPK-Relish signaling pathway. </div> <a href="javascript:ShowArticleAbstract(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Crassostrea+gigas%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Crassostrea gigas</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Granulocytes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Granulocytes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+regulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune regulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Norepinephrine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Norepinephrine</a></li></ul> <a href="javascript:ShowArticleKeywords(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Crassostrea%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Crassostrea/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Norepinephrine%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Norepinephrine/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Norepinephrine%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Norepinephrine/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Granulocytes%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Granulocytes/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Granulocytes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Granulocytes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22p38+Mitogen-Activated+Protein+Kinases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">p38 Mitogen-Activated Protein Kinases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunity%2c+Innate%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunity, Innate</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipopolysaccharides%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipopolysaccharides/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apoptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apoptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phagocytosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phagocytosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cells%2c+Cultured%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cells, Cultured</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Necrosis+Factor-alpha%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Necrosis Factor-alpha/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Regulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Regulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAP+Kinase+Signaling+System%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAP Kinase Signaling System/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Necrosis+Factors%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Necrosis Factors/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Necrosis+Factors%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Necrosis Factors/genetics</a></li></ul> <a href="javascript:ShowArticleMeSH(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(6);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow7"> <td style="min-width: 40px; text-align: center;"> 7 </td> <td> <div id="citation7" class="article-citation"> <b>Wang J</b>, Amoah S, Stafford JL. A leukocyte immune-type receptor specific polyclonal antibody recognizes goldfish kidney leukocytes and activates the MAPK pathway in isolated goldfish kidney neutrophil-like cells. <em>DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY</em> 2024;<b>159</b>:105228. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38997096' target='_blank'>38997096</a> DOI: <a href='https://dx.doi.org/10.1016/j.dci.2024.105228' target='_blank'>10.1016/j.dci.2024.105228</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.dci.2024.105228','38997096', 'MAP Kinase Signaling System/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(7);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(7);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(7);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.dci.2024.105228' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/14/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv7" value="10.1016/j.dci.2024.105228" /> <div style="display: none" id="articleAbstract7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Leukocyte immune-type receptors (LITRs) belong to a large family of teleost immunoregulatory receptors that share phylogenetic and syntenic relationships with mammalian Fc receptor-like molecules (FCRLs). Recently, several putative stimulatory Carassius auratus (Ca)-LITR transcripts, including CaLITR3, have been identified in goldfish. CaLITR3 has four extracellular immunoglobulin-like (Ig-like) domains, a transmembrane domain containing a positively charged histidine residue, and a short cytoplasmic tail region. Additionally, the calitr3 transcript is highly expressed by goldfish primary kidney neutrophils (PKNs) and macrophages (PKMs). To further investigate the immunoregulatory potential of CaLITR3 in goldfish myeloid cells, we developed and characterized a CaLITR3-epitope-specific polyclonal antibody (anti-CaL3.D1 pAb). We show that the anti-CaL3.D1 pAb stains various hematopoietic cell types within the goldfish kidney, as well as in PKNs and PKMs. Moreover, cross-linking of the anti-CaL3.D1-pAb on PKN membranes induces phosphorylation of p38 and ERK1/2, critical components of the MAPK pathway involved in controlling a wide variety of innate immune effector responses such as NETosis, respiratory burst, and cytokine release. These findings support the stimulatory potential of CaLITR3 proteins as activators of fish granulocytes and pave the way for a more in-depth examination of the immunoregulatory functions of CaLITRs in goldfish myeloid cells. </div> <a href="javascript:ShowArticleAbstract(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fc+receptor-like+molecules%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fc receptor-like molecules</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fish+immunity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fish immunity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Innate+immune+receptors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Innate immune receptors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Teleost+neutrophils%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Teleost neutrophils</a></li></ul> <a href="javascript:ShowArticleKeywords(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Goldfish%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Goldfish/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fish+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fish Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fish+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fish Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fish+Proteins%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fish Proteins/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neutrophils%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neutrophils/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney%2fcytology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney/cytology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAP+Kinase+Signaling+System%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAP Kinase Signaling System/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Immunologic%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Immunologic/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Immunologic%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Immunologic/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Immunologic%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Immunologic/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antibodies%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antibodies/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antibodies%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antibodies/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cells%2c+Cultured%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cells, Cultured</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Leukocytes%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Leukocytes/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Leukocytes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Leukocytes/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(7);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow8"> <td style="min-width: 40px; text-align: center;"> 8 </td> <td> <div id="citation8" class="article-citation"> <b>Gao F</b>, Zhao Y, Zhang Y, Gu Y, Pei C, Li C, Kong X. CcPTGS2a-like gene-mediated NF-κB/ERK signaling regulation in the common carp (Cyprinus carpio). <em>FISH & SHELLFISH IMMUNOLOGY</em> 2024;<b>152</b>:109783. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39032705' target='_blank'>39032705</a> DOI: <a href='https://dx.doi.org/10.1016/j.fsi.2024.109783' target='_blank'>10.1016/j.fsi.2024.109783</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.fsi.2024.109783','39032705', 'MAP Kinase Signaling System/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(8);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(8);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(8);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.fsi.2024.109783' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/15/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/11/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/23/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv8" value="10.1016/j.fsi.2024.109783" /> <div style="display: none" id="articleAbstract8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Prostaglandin-endoperoxide synthase 2 (PTGS2), a common biological macromolecule, is pivotal for innate immunity and pathogen recognition. In this study, we identified and characterized a CcPTGS2a-like gene in the common carp (Cyprinus carpio) with an open reading frame (ORF) of 1821 bp and epidermal growth factor and peroxidase domains. Our multiple sequence analysis revealed high homology between the amino acid sequence of CcPTGS2a-like and those of its homologs in other fish. CcPTGS2a-like mRNA and protein expressions were significantly upregulated in the spleen, head kidney, liver, and gill tissues upon exposure to Aeromonas hydrophila stimulation. CcPTGS2a-like protein recognized the conserved bacterial surface components and exhibited detectable bacterial binding activity. CcPTGS2a-like overexpression before exposure to A. hydrophila notably enhanced the survival rate of common carp, concomitant with decreased bacterial burden. The NF-κB/ERK signaling pathway initiated the immune response in common carp upon infection with A. hydrophila. CcPTGS2a-like overexpression or interference in the head kidney and Epithelioma papulosum cyprinid cells could modulate the p-NF-κB (p-p-65), p-IκBα, and p-ERK1/2 levels as well as the IL-1β and IL-6 mRNA expression. These results indicated potential CcPTGS2a-like involvement in the immune response of the common carp to bacterial infections through the NF-κB/ERK signaling pathway. </div> <a href="javascript:ShowArticleAbstract(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CcPTGS2a-like%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CcPTGS2a-like</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Common+carp%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Common carp</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ERK1%2f2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ERK1/2</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF-%ce%baB%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF-κB</a></li></ul> <a href="javascript:ShowArticleKeywords(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carps%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carps/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carps%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carps/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aeromonas+hydrophila%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aeromonas hydrophila/physiology</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phylogeny%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phylogeny</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sequence+Alignment%2fveterinary%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sequence Alignment/veterinary</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Profiling%2fveterinary%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Profiling/veterinary</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAP+Kinase+Signaling+System%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAP Kinase Signaling System/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Base+Sequence%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Base Sequence</a></li></ul> <a href="javascript:ShowArticleMeSH(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(8);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow9"> <td style="min-width: 40px; text-align: center;"> 9 </td> <td> <div id="citation9" class="article-citation"> <b>Sun J</b>, Shi M, Song Z, Hua F, Yan X, Zhang M, Duan H, Liu J. CD146-dependent macrophage infiltration promotes epidural fibrosis via the Erdr1/ERK/CCR2 pathway. <em class='incite-journal-name' onclick='ShowInCiteJournal(11367);'>Int Immunopharmacol</em> 2024;<b>137</b>:112528. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38908086' target='_blank'>38908086</a> DOI: <a href='https://dx.doi.org/10.1016/j.intimp.2024.112528' target='_blank'>10.1016/j.intimp.2024.112528</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.intimp.2024.112528','38908086', 'MAP Kinase Signaling System/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(9);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(9);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(9);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.intimp.2024.112528' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11367);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 06/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/24/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv9" value="10.1016/j.intimp.2024.112528" /> <div style="display: none" id="articleAbstract9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Low back pain due to epidural fibrosis is a major complication after spine surgery. Macrophages infiltrate the wound area post laminectomy, but the role of macrophages in epidural fibrosis remains largely elusive. In a mouse model of laminectomy, macrophage depletion decreased epidural fibrosis. CD146, an adhesion molecule involved in cell migration, is expressed by macrophages. CD146-defective macrophages exhibited impaired migration, which was mediated by reduced expression of CCR2 and suppression of the MAPK/ERK signaling pathway. CD146-defective macrophages suppress the MAPK/ERK signaling pathway by increasing Erdr1. In vivo, CD146 deficiency decreased macrophage infiltration and reduced extracellular matrix deposition in wound tissues. Moreover, the anti-CD146 antibody AA98 suppressed macrophage infiltration and epidural fibrosis. Taken together, these findings demonstrated that CD146 deficiency alleviates epidural fibrosis by decreasing the migration of macrophages via the Erdr1/ERK/CCR2 pathway. Blocking CD146 and macrophage infiltration may help alleviate epidural fibrosis. </div> <a href="javascript:ShowArticleAbstract(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CCR2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CCR2</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CD146%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CD146</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epidural+fibrosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epidural fibrosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Erdr1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Erdr1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Laminectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Laminectomy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophage</a></li></ul> <a href="javascript:ShowArticleKeywords(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+CCR2%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, CCR2/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+CCR2%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, CCR2/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fibrosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fibrosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CD146+Antigen%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CD146 Antigen/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CD146+Antigen%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CD146 Antigen/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Movement%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Movement</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Knockout%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Knockout</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epidural+Space%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epidural Space/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAP+Kinase+Signaling+System%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAP Kinase Signaling System/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Laminectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Laminectomy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li></ul> <a href="javascript:ShowArticleMeSH(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(9);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow10"> <td style="min-width: 40px; text-align: center;"> 10 </td> <td> <div id="citation10" class="article-citation"> <b>Virard F</b>, Giraud S, Bonnet M, Magadoux L, Martin L, Pham TH, Skafi N, Deneuve S, Frem R, Villoutreix BO, Sleiman NH, Reboulet J, Merabet S, Chaptal V, Chaveroux C, Hussein N, Aznar N, Fenouil T, Treilleux I, Saintigny P, Ansieau S, Manié S, Lebecque S, Renno T, Coste I. Targeting ERK-MYD88 interaction leads to ERK dysregulation and immunogenic cancer cell death. <em class='incite-journal-name' onclick='ShowInCiteJournal(17180);'>Nat Commun</em> 2024;<b>15</b>:7037. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39147750' target='_blank'>39147750</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11327251' target='_blank'>PMC11327251</a> DOI: <a href='https://dx.doi.org/10.1038/s41467-024-51275-z' target='_blank'>10.1038/s41467-024-51275-z</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s41467-024-51275-z','39147750', 'MAP Kinase Signaling System/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(10);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(10);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(10);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(10);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1038/s41467-024-51275-z' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17180);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/17/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv10" value="10.1038/s41467-024-51275-z" /> <div style="display: none" id="articleAbstract10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The quest for targeted therapies is critical in the battle against cancer. The RAS/MAP kinase pathway is frequently implicated in neoplasia, with ERK playing a crucial role as the most distal kinase in the RAS signaling cascade. Our previous research demonstrated that the interaction between ERK and MYD88, an adaptor protein in innate immunity, is crucial for RAS-dependent transformation and cancer cell survival. In this study, we examine the biological consequences of disrupting the ERK-MYD88 interaction through the ERK D-recruitment site (DRS), while preserving ERK's kinase activity. Our results indicate that EI-52, a small-molecule benzimidazole targeting ERK-MYD88 interaction induces an HRI-mediated integrated stress response (ISR), resulting in immunogenic apoptosis specific to cancer cells. Additionally, EI-52 exhibits anti-tumor efficacy in patient-derived tumors and induces an anti-tumor T cell response in mice in vivo. These findings suggest that inhibiting the ERK-MYD88 interaction may be a promising therapeutic approach in cancer treatment. </div> <a href="javascript:ShowArticleAbstract(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22targeted+therapies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">targeted therapies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22drug+development%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">drug development</a></li></ul> <a href="javascript:ShowArticleKeywords(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myeloid+Differentiation+Factor+88%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myeloid Differentiation Factor 88/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myeloid+Differentiation+Factor+88%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myeloid Differentiation Factor 88/genetics</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Benzimidazoles%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Benzimidazoles/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apoptosis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apoptosis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunogenic+Cell+Death%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunogenic Cell Death/drug effects</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAP+Kinase+Signaling+System%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAP Kinase Signaling System/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAP+Kinase+Signaling+System%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAP Kinase Signaling System/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Xenograft+Model+Antitumor+Assays%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Xenograft Model Antitumor Assays</a></li><li><a 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Contre le Cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Institut+National+Du+Cancer+(French+National+Cancer+Institute)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2020-119 Institut National Du Cancer (French National Cancer Institute)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fondation+ARC+pour+la+Recherche+sur+le+Cancer+(ARC+Foundation+for+Cancer+Research)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PJA20171206416 Fondation ARC pour la Recherche sur le Cancer (ARC Foundation for Cancer Research)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Agence+Nationale+de+la+Recherche+(French+National+Research+Agency)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ANR-11-EQPX-0035 Agence Nationale de la Recherche (French National Research Agency)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pulsalys+(Pulsalys+Satt+Lyon+Saint-Etienne)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">D02576 Pulsalys (Pulsalys Satt Lyon Saint-Etienne)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Integrated+Cancer+Research+Site+LYriCAN+(INCa-DGOS-Inserm_12563)+Synergy+Lyon+Cancer+Foundation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Integrated Cancer Research Site LYriCAN (INCa-DGOS-Inserm_12563) Synergy Lyon Cancer Foundation</a></li></ul> <a href="javascript:ShowArticleGrant(10);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow11"> <td style="min-width: 40px; text-align: center;"> 11 </td> <td> <div id="citation11" class="article-citation"> <b>Dong M</b>, Wang W, Wu W, Cheng X, Cheng J, Wang L, Song L. A novel surface marker CD49d promotes TNF expression in oyster agranulocytes by mediating the MAPK pathway. <em>FISH & SHELLFISH IMMUNOLOGY</em> 2024;<b>151</b>:109702. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38897309' target='_blank'>38897309</a> DOI: <a href='https://dx.doi.org/10.1016/j.fsi.2024.109702' target='_blank'>10.1016/j.fsi.2024.109702</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.fsi.2024.109702','38897309', 'MAP Kinase Signaling System/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(11);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(11);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(11);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.fsi.2024.109702' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 06/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/13/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/21/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv11" value="10.1016/j.fsi.2024.109702" /> <div style="display: none" id="articleAbstract11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">CD49d, encoded by the gene Integrin α4, is a significant member of cell adhesion receptors, which is widely expressed in various immune cells to trigger immune responses against invading pathogens. In the present study, the expression of CgCD49d and its regulatory role in TNF expression were investigated in the Pacific oyster Crassostrea gigas. There were five Int-alpha domains, an Integrin_alpha2 region and a unique FG-GAP repeat region inserted identified in CgCD49d. CgCD49d transcript was specifically expressed in haemocytes, and its mRNA expression level in haemocytes increased after LPS and Vibrio splendidus stimulation. After CgCD49d was blocked by using its antibody, the phosphorylation level of CgJNK in the MAPK signaling pathway and CgTNF transcripts decreased significantly post V. splendidus stimulation. After phosphorylation level of CgJNK was inhibited by using its inhibitor, the nuclear translocation of CgRel was restrained and CgTNF transcripts also decreased significantly post V. splendidus stimulation. Furthermore, CgCD49d was found to be mainly expressed in the agranulocyte subpopulation, and Alexa Fluor 488-conjugated CgCD49d antibody labeled agranulocytes with a circle of green fluorescence signals on CgCD49d+ agranulocyte surface under Confocal microscopy, which accounted for 24.9 ± 4.53% of total haemocytes. Collectively, these results suggested that CgCD49d promoted TNF expression in oyster haemocytes against bacterial invasion by mediating MAPK pathway, and it could be used as a surface marker to type and sort a subset of agranulocyte subpopulation among haemocytes. </div> <a href="javascript:ShowArticleAbstract(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Agranulocytes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Agranulocytes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CD49d%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CD49d</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Crassostrea+gigas%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Crassostrea gigas</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAPK%2fJNK+pathway%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAPK/JNK pathway</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TNF%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TNF</a></li></ul> <a href="javascript:ShowArticleKeywords(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Crassostrea%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Crassostrea/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Crassostrea%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Crassostrea/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hemocytes%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hemocytes/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Vibrio%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Vibrio/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAP+Kinase+Signaling+System%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAP Kinase Signaling System/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipopolysaccharides%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipopolysaccharides/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Necrosis+Factor-alpha%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Necrosis Factor-alpha/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Necrosis+Factor-alpha%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Necrosis Factor-alpha/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Necrosis+Factor-alpha%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Necrosis Factor-alpha/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Regulation%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Regulation/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunity%2c+Innate%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunity, Innate/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Amino+Acid+Sequence%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Amino Acid Sequence</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phylogeny%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phylogeny</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sequence+Alignment%2fveterinary%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sequence Alignment/veterinary</a></li></ul> <a href="javascript:ShowArticleMeSH(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(11);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow12"> <td style="min-width: 40px; text-align: center;"> 12 </td> <td> <div id="citation12" class="article-citation"> <b>Du YT</b>, Zhang HQ, Li Y, Li XP, Yuan ZZ, Li MF. Teleost-specific TLR23 in Takifugu rubripes recruits MyD88 to trigger ERK pathway and promotes antibacterial defense. <em>FISH & SHELLFISH IMMUNOLOGY</em> 2024;<b>151</b>:109724. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38942251' target='_blank'>38942251</a> DOI: <a href='https://dx.doi.org/10.1016/j.fsi.2024.109724' target='_blank'>10.1016/j.fsi.2024.109724</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.fsi.2024.109724','38942251', 'MAP Kinase Signaling System/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(12);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(12);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(12);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.fsi.2024.109724' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/13/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 06/13/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/30/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv12" value="10.1016/j.fsi.2024.109724" /> <div style="display: none" id="articleAbstract12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Takifugu rubripes is a highly valued cultured fish in Asia, while pathogen infections can result in severe diseases and lead to substantial economic losses. Toll-like receptors (TLRs), as pattern recognition receptors, play a crucial role on recognition pathogens and initiation innate immune response. However, the immunological properties of teleost-specific TLR23 remain largely unknown. In this study, we investigated the biological functions of TLR23 (TrTLR23) from T. rubripes, found that TrTLR23 existed in various organs. Following bacterial pathogen challenge, the expression levels of TrTLR23 were significantly increased in immune related organs. TrTLR23 located on the cellular membrane and specifically recognized pathogenic microorganism. Co-immunoprecipitation and antibody blocking analysis revealed that TrTLR23 recruited myeloid differentiation primary response protein (MyD88), thereby mediating the activation of the ERK signaling pathway. Furthermore, in vivo showed that, when TrTLR23 is overexpressed in T. rubripes, bacterial replication in fish tissues is significantly inhibited. Consistently, when TrTLR23 expression in T. rubripes is knocked down, bacterial replication is significantly enhanced. In conclusion, these findings suggested that TrTLR23 played a critical role on mediation TLR23-MyD88-ERK axis against bacterial infection. This study revealed that TLR23 involved in the innate immune mechanism, and provided the foundation for development disease control strategies in teleost. </div> <a href="javascript:ShowArticleAbstract(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bacterial+infection%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bacterial infection</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TLR23%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TLR23</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Takifugu+rubripes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Takifugu rubripes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Toll-like+receptor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Toll-like receptor</a></li></ul> <a href="javascript:ShowArticleKeywords(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fish+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fish Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fish+Proteins%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fish Proteins/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Takifugu%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Takifugu/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Takifugu%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Takifugu/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fish+Diseases%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fish Diseases/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myeloid+Differentiation+Factor+88%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myeloid Differentiation Factor 88/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myeloid+Differentiation+Factor+88%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myeloid Differentiation Factor 88/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myeloid+Differentiation+Factor+88%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myeloid Differentiation Factor 88/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunity%2c+Innate%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunity, Innate/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Toll-Like+Receptors%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Toll-Like Receptors/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Toll-Like+Receptors%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Toll-Like Receptors/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Toll-Like+Receptors%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Toll-Like Receptors/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAP+Kinase+Signaling+System%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAP Kinase Signaling System/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Regulation%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Regulation/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Edwardsiella%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Edwardsiella/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Edwardsiella%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Edwardsiella/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Vibrio%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Vibrio/physiology</a></li></ul> <a href="javascript:ShowArticleMeSH(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(12);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow13"> <td style="min-width: 40px; text-align: center;"> 13 </td> <td> <div id="citation13" class="article-citation"> <b>Kumari S</b>, Bodhale N, Sarode A, Jha MK, Bhadange S, Pandey SP, Selvaraj S, Chande AG, Mukhopadhyaya R, Ghosh SK, Singh S, Mukherjee D, Duffin R, Andrews P, Saha B. Leishmania major MAPK4 intercepts and redirects CD40 signaling promoting infection. <em class='incite-journal-name' onclick='ShowInCiteJournal(11367);'>Int Immunopharmacol</em> 2024;<b>134</b>:112100. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38728877' target='_blank'>38728877</a> DOI: <a href='https://dx.doi.org/10.1016/j.intimp.2024.112100' target='_blank'>10.1016/j.intimp.2024.112100</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.intimp.2024.112100','38728877', 'MAP Kinase Signaling System/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(13);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(13);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.intimp.2024.112100' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11367);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 11/11/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 04/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 04/13/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 05/12/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv13" value="10.1016/j.intimp.2024.112100" /> <div style="display: none" id="articleAbstract13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The parasite Leishmania resides as amastigotes within the macrophage parasitophorous vacuoles inflicting the disease Leishmaniasis. Leishmania selectively modulates mitogen-activated protein kinase (MAPK) phosphorylation subverting CD40-triggered anti-leishmanial functions of macrophages. The mechanism of any pathogen-derived molecule induced host MAPK modulation remains poorly understood. Herein, we show that of the fifteen MAPKs, LmjMAPK4 expression is higher in virulent L. major. LmjMAPK4- detected in parasitophorous vacuoles and cytoplasm- binds MEK-1/2, but not MKK-3/6. Lentivirally-overexpressed LmjMAPK4 augments CD40-activated MEK-1/2-ERK-1/2-MKP-1, but inhibits MKK3/6-p38MAPK-MKP-3, phosphorylation. A rationally-identified LmjMAPK4 inhibitor reinstates CD40-activated host-protective anti-leishmanial functions in L. major-infected susceptible BALB/c mice. These results identify LmjMAPK4 as a MAPK modulator at the host-pathogen interface and establish a pathogen-intercepted host receptor signaling as a scientific rationale for identifying drug targets. </div> <a href="javascript:ShowArticleAbstract(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Leishmania+major%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Leishmania major/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Leishmania+major%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Leishmania major/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CD40+Antigens%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CD40 Antigens/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+BALB+C%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred BALB C</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Leishmaniasis%2c+Cutaneous%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Leishmaniasis, Cutaneous/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Leishmaniasis%2c+Cutaneous%2fparasitology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Leishmaniasis, Cutaneous/parasitology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fparasitology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/parasitology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phosphorylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phosphorylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Host-Parasite+Interactions%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Host-Parasite Interactions/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAP+Kinase+Signaling+System%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAP Kinase Signaling System/immunology</a></li></ul> <a href="javascript:ShowArticleMeSH(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(13);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow14"> <td style="min-width: 40px; text-align: center;"> 14 </td> <td> <div id="citation14" class="article-citation"> <b>Wang T</b>, Ge H, Lin P, Wang Y, Lai X, Chen P, Li F, Feng J. Toll-interacting protein is activated by the transcription factor GATA1 and Sp1 to negatively regulate NF-κB and MAPK pathways in the Japanese eel (Anguilla japonica). <em>FISH & SHELLFISH IMMUNOLOGY</em> 2024;<b>149</b>:109561. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38636738' target='_blank'>38636738</a> DOI: <a href='https://dx.doi.org/10.1016/j.fsi.2024.109561' target='_blank'>10.1016/j.fsi.2024.109561</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.fsi.2024.109561','38636738', 'MAP Kinase Signaling System/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(14);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(14);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(14);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.fsi.2024.109561' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 11/15/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 04/11/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 04/11/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 04/20/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv14" value="10.1016/j.fsi.2024.109561" /> <div style="display: none" id="articleAbstract14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Toll-interacting protein (Tollip) serves as a crucial inhibitory factor in the modulation of Toll-like receptor (TLR)-mediated innate immunological responses. The structure and function of Tollip have been well documented in mammals, yet the information in teleost remained limited. This work employed in vitro overexpression and RNA interference in vivo and in vitro to comprehensively examine the regulatory effects of AjTollip on NF-κB and MAPK signaling pathways. The levels of p65, c-Fos, c-Jun, IL-1, IL-6, and TNF-α were dramatically reduced following overexpression of AjTollip, whereas knocking down AjTollip in vivo and in vitro enhanced those genes' expression. Protein molecular docking simulations showed AjTollip interacts with AjTLR2, AjIRAK4a, and AjIRAK4b. A better understanding of the transcriptional regulation of AjTollip is crucial to elucidating the role of Tollip in fish antibacterial response. Herein, we cloned and characterized a 2.2 kb AjTollip gene promoter sequence. The transcription factors GATA1 and Sp1 were determined to be associated with the activation of AjTollip expression by using promoter truncation and targeted mutagenesis techniques. Collectively, our results indicate that AjTollip suppresses the NF-κB and MAPK signaling pathways, leading to the decreased expression of the downstream inflammatory factors, and GATA1 and Sp1 play a vital role in regulating AjTollip expression. </div> <a href="javascript:ShowArticleAbstract(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anguilla+japonica%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anguilla japonica</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Promoter%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Promoter</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+docking%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein docking</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNAi%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNAi</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tollip%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tollip</a></li></ul> <a href="javascript:ShowArticleKeywords(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fish+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fish Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fish+Proteins%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fish Proteins/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fish+Proteins%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fish Proteins/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fish+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fish Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF-kappa+B%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF-kappa B/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF-kappa+B%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF-kappa B/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GATA1+Transcription+Factor%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GATA1 Transcription Factor/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GATA1+Transcription+Factor%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GATA1 Transcription Factor/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anguilla%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anguilla/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anguilla%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anguilla/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sp1+Transcription+Factor%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sp1 Transcription Factor/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sp1+Transcription+Factor%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sp1 Transcription Factor/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Regulation%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Regulation/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunity%2c+Innate%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunity, Innate/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAP+Kinase+Signaling+System%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAP Kinase Signaling System/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAP+Kinase+Signaling+System%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAP Kinase Signaling System/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intracellular+Signaling+Peptides+and+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intracellular Signaling Peptides and Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intracellular+Signaling+Peptides+and+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intracellular Signaling Peptides and Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intracellular+Signaling+Peptides+and+Proteins%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intracellular Signaling Peptides and Proteins/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intracellular+Signaling+Peptides+and+Proteins%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intracellular Signaling Peptides and Proteins/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction</a></li></ul> <a href="javascript:ShowArticleMeSH(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(14);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow15"> <td style="min-width: 40px; text-align: center;"> 15 </td> <td> <div id="citation15" class="article-citation"> <b>Ma S</b>, Wu Q, Wu W, Tian Y, Zhang J, Chen C, Sheng X, Zhao F, Ding L, Wang T, Zhao L, Xie Y, Wang Y, Yue X, Wu Z, Wei J, Zhang K, Liang X, Gao L, Wang H, Wang G, Li C, Ma C. Urolithin A Hijacks ERK1/2-ULK1 Cascade to Improve CD8<sup>+</sup> T Cell Fitness for Antitumor Immunity. <em>ADVANCED SCIENCE (WEINHEIM, BADEN-WURTTEMBERG, GERMANY)</em> 2024;<b>11</b>:e2310065. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38447147' target='_blank'>38447147</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11095213' target='_blank'>PMC11095213</a> DOI: <a href='https://dx.doi.org/10.1002/advs.202310065' target='_blank'>10.1002/advs.202310065</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/advs.202310065','38447147', 'MAP Kinase Signaling System/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(15);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(15);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(15);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(15);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1002/advs.202310065' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 12/21/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 02/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 03/08/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv15" value="10.1002/advs.202310065" /> <div style="display: none" id="articleAbstract15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">According to the latest evidence, the microbial metabolite Urolithin A (UA), known for its role in promoting cellular health, modulates CD8+ T cell-mediated antitumor activity. However, the direct target protein of UA and its underlying mechanism remains unclear. Here, this research identifies ERK1/2 as the specific target crucial for UA-mediated CD8+ T cell activation. Even at low doses, UA markedly enhances the persistence and effector functions of primary CD8+ cytotoxic T lymphocytes (CTLs) and human chimeric antigen receptor (CAR) T cells both in vitro and in vivo. Mechanistically, UA interacts directly with ERK1/2 kinases, enhancing their activation and subsequently facilitating T cell activation by engaging ULK1. The UA-ERK1/2-ULK1 axis promotes autophagic flux in CD8+ CTLs, enhancing cellular metabolism and maintaining reactive oxygen species (ROS) levels, as evidenced by increased oxygen consumption and extracellular acidification rates. UA-treated CD8+ CTLs also display elevated ATP levels and enhanced spare respiratory capacity. Overall, UA activates ERK1/2, inducing autophagy and metabolic adaptation, showcasing its potential in tumor immunotherapy and interventions for diseases involving ERKs. </div> <a href="javascript:ShowArticleAbstract(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CAR+T+cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CAR T cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CD8%2b+cytotoxic+T+cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CD8+ cytotoxic T cells</a></li><li><a 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Tropomyosin 2 Regulates Tumor Cell Proliferation, Immune Suppression, and Activation of the JNK Signaling Pathway in Colitis-Associated Cancer (CAC). <em>DISCOVERY MEDICINE</em> 2024;<b>36</b>:778-787. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38665026' target='_blank'>38665026</a> DOI: <a href='https://dx.doi.org/10.24976/discov.med.202436183.73' target='_blank'>10.24976/discov.med.202436183.73</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.24976/discov.med.202436183.73','38665026', 'MAP Kinase Signaling System/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(16);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(16);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(16);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.24976/discov.med.202436183.73' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 05/12/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv16" value="10.24976/discov.med.202436183.73" /> <div style="display: none" id="articleAbstract16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Tropomyosin 2 (TPM2) has been linked to the advancement of various tumor types, exhibiting distinct impacts on tumor progression. In our investigation, the primary objective was to identify the potential involvement of TPM2 in the development of colitis-associated cancer (CAC) using a mice model. </div><div class="abstract-label">METHODS</div><div class="abstract-content">This study used lentiviral vector complex for TPM2 knockdown (sh-TPM2) and the corresponding negative control lentiviral vector complex (sh-NC) for genetic interference in mice. CAC was induced in mice using azoxymethane (AOM) and dextran sulfate sodium salt (DSS). This study included 6 groups of mice models: Control, Control+sh-NC, Control+sh-TPM2, CAC, CAC+sh-NC, and CAC+sh-TPM2. Subsequently, colon tissues were collected and assessed using quantitative reverse transcription-polymerase chain reaction (qRT-PCR) for TPM2 mRNA levels and flow cytometry for infiltrating immune cells. Tumor number, size, and weight within colon tissues from CAC mice were measured and recorded. The hematoxylin-eosin staining was used for observing tissue pathology changes. The intestinal epithelial cells (IECs) were isolated and analyzed for cell proliferation. This analysis included examining the levels of 5-bromo-2-deoxyuridine (BrdU) and Ki-67 using immunohistochemistry. Additionally, the mRNA levels of proliferating cell nuclear antigen (PCNA) and Ki-67 were detected by qRT-PCR. This study also investigated the activation of the c-Jun N-terminal kinase (JNK) pathway using western blot analysis. Immunogenicity analyses were conducted using immunohistochemistry for F4/80 and flow cytometry. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">In 8-week-old mice, AOM injections and three cycles of DSS treatment induced TPM2 upregulation in tumor tissues compared to normal tissues (p < 0.05). Fluorescence-activated cell sorting (FACS)-isolated lamina CAC adenomas revealed macrophages and dendritic cells as primary TPM2 contributors (p < 0.001). Lentiviral TPM2 gene knockdown significantly reduced tumor numbers and sizes in CAC mice (p < 0.01, and p < 0.001), without invasive cancer cells. TPM2 suppression resulted in decreased IEC proliferation (p < 0.001) and reduced PCNA and Ki-67 expression (p < 0.05). Western blot analysis indicated reduced JNK pathway activation in TPM2-knockdown CAC mice (p < 0.05, p < 0.001). TPM2 knockdown decreased tumor-associated macrophage infiltration (p < 0.01) and increased CD3+ and CD8+ T cells (p < 0.01, and p < 0.001), with increased levels of regulator of inflammatory cytokines (CD44+, CD107a+) (p < 0.01, and p < 0.001), decreased levels of PD-1+ and anti-inflammatory factor (IL10+) (p < 0.01, and p < 0.001). </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">Our results demonstrated that TPM2 knockdown suppressed the proliferation of CAC IECs, enhanced immune suppression on CAC IECs, and inhibited the JNK signaling pathway within the framework of CAC. These findings suggest TPM2 can serve as a potential therapeutic target for CAC treatment. </div> <a href="javascript:ShowArticleAbstract(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22JNK+signal+pathway%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">JNK signal pathway</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22colitis-associated+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">colitis-associated cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22immunosuppression%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">immunosuppression</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22proliferation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">proliferation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22tropomyosin+2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">tropomyosin 2</a></li></ul> <a href="javascript:ShowArticleKeywords(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Azoxymethane%2ftoxicity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Azoxymethane/toxicity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Proliferation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Proliferation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colitis%2fchemically+induced%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colitis/chemically induced</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colitis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colitis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colitis%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colitis/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colitis%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colitis/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colitis-Associated+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colitis-Associated Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colitis-Associated+Neoplasms%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colitis-Associated Neoplasms/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colitis-Associated+Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colitis-Associated Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dextran+Sulfate%2ftoxicity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dextran Sulfate/toxicity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAP+Kinase+Signaling+System%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAP Kinase Signaling System/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tropomyosin%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tropomyosin/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tropomyosin%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tropomyosin/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tropomyosin%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tropomyosin/genetics</a></li></ul> <a href="javascript:ShowArticleMeSH(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(16);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow17"> <td style="min-width: 40px; text-align: center;"> 17 </td> <td> <div id="citation17" class="article-citation"> <b>Vaccaro K</b>, Allen J, Whitfield TW, Maoz A, Reeves S, Velarde J, Yang D, Meglan A, Ribeiro J, Blandin J, Phan N, Bell GW, Hata AN, Weiskopf K. Targeted therapies prime oncogene-driven lung cancers for macrophage-mediated destruction. <em class='incite-journal-name' onclick='ShowInCiteJournal(13335);'>J Clin Invest</em> 2024;<b>134</b>:e169315. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38483480' target='_blank'>38483480</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11060739' target='_blank'>PMC11060739</a> DOI: <a href='https://dx.doi.org/10.1172/jci169315' target='_blank'>10.1172/jci169315</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1172/jci169315','38483480', 'MAP Kinase Signaling System/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(17);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(17);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(17);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(17);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1172/jci169315' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(13335);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/07/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 03/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 03/26/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv17" value="10.1172/jci169315" /> <div style="display: none" id="articleAbstract17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Macrophage immune checkpoint inhibitors, such as anti-CD47 antibodies, show promise in clinical trials for solid and hematologic malignancies. However, the best strategies to use these therapies remain unknown, and ongoing studies suggest they may be most effective when used in combination with other anticancer agents. Here, we developed an unbiased, high-throughput screening platform to identify drugs that render lung cancer cells more vulnerable to macrophage attack, and we found that therapeutic synergy exists between genotype-directed therapies and anti-CD47 antibodies. In validation studies, we found that the combination of genotype-directed therapies and CD47 blockade elicited robust phagocytosis and eliminated persister cells in vitro and maximized antitumor responses in vivo. Importantly, these findings broadly applied to lung cancers with various RTK/MAPK pathway alterations - including EGFR mutations, ALK fusions, or KRASG12C mutations. We observed downregulation of β2-microglobulin and CD73 as molecular mechanisms contributing to enhanced sensitivity to macrophage attack. Our findings demonstrate that dual inhibition of the RTK/MAPK pathway and the CD47/SIRPa axis is a promising immunotherapeutic strategy. Our study provides strong rationale for testing this therapeutic combination in patients with lung cancers bearing driver mutations. </div> <a href="javascript:ShowArticleAbstract(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cancer+immunotherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cancer immunotherapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lung+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lung cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oncology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oncology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Therapeutics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Therapeutics</a></li></ul> <a href="javascript:ShowArticleKeywords(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lung+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lung Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lung+Neoplasms%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lung Neoplasms/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lung+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lung Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lung+Neoplasms%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lung Neoplasms/immunology</a></li><li><a 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MALT1 regulates Th2 and Th17 differentiation via NF-κB and JNK pathways, as well as correlates with disease activity and treatment outcome in rheumatoid arthritis. <em class='incite-journal-name' onclick='ShowInCiteJournal(9345);'>Front Immunol</em> 2022;<b>13</b>:913830. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/35967391' target='_blank'>35967391</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367691' target='_blank'>PMC9367691</a> DOI: <a href='https://dx.doi.org/10.3389/fimmu.2022.913830' target='_blank'>10.3389/fimmu.2022.913830</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.3389%2ffimmu.2022.913830%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 5</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.3389%2ffimmu.2022.913830')">Impact Index Per Article: 2.5</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3389/fimmu.2022.913830','35967391', 'MAP Kinase Signaling System/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(18);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(18);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3389/fimmu.2022.913830' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/3edf0441a994e25c0db02ffef6e63414/PMC9367691.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.3389/fimmu.2022.913830');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9345);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/06/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/30/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/17/2022]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv18" value="10.3389/fimmu.2022.913830" /> <div style="display: none" id="articleAbstract18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">Objective</div><p>MALT1 regulates immunity and inflammation in multiple ways, while its role in rheumatoid arthritis (RA) is obscure. This study aimed to investigate the relationship of MALT1 with disease features, treatment outcome, as well as its effect on Th1/2/17 cell differentiation and underlying molecule mechanism in RA.</p><div class="abstract-label">Methods</div><p>Totally 147 RA patients were enrolled. Then their blood Th1, Th2, and Th17 cells were detected by flow cytometry. Besides, PBMC MALT1 expression was detected before treatment (baseline), at week (W) 6, W12, and W24. PBMC MALT1 in 30 osteoarthritis patients and 30 health controls were also detected. Then, blood CD4<sup>+</sup> T cells were isolated from RA patients, followed by MALT1 overexpression or knockdown lentivirus transfection and Th1/2/17 polarization assay. In addition, IMD 0354 (NF-κB antagonist) and SP600125 (JNK antagonist) were also added to treat CD4<sup>+</sup> T cells.</p><div class="abstract-label">Results</div><p>MALT1 was increased in RA patients compared to osteoarthritis patients and healthy controls. Meanwhile, MALT1 positively related to CRP, ESR, DAS28 score, Th17 cells, negatively linked with Th2 cells, but did not link with other features or Th1 cells in RA patients. Notably, MALT1 decreased longitudinally during treatment, whose decrement correlated with RA treatment outcome (treatment response, low disease activity, or disease remission). In addition, MALT1 overexpression promoted Th17 differentiation, inhibited Th2 differentiation, less affected Th1 differentiation, activated NF-κB and JNK pathways in RA CD4<sup>+</sup> T cells; while MALT1 knockdown exhibited the opposite effect. Besides, IMD 0354 and SP600125 addition attenuated MALT1’s effect on Th2 and Th17 differentiation.</p><div class="abstract-label">Conclusion</div><p>MALT1 regulates Th2 and Th17 differentiation <italic>via</italic> NF-κB and JNK pathways, as well as correlates with disease activity and treatment outcome in RA.</p> <a href="javascript:ShowArticleAbstract(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Rheumatoid%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Rheumatoid/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Rheumatoid%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Rheumatoid/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Rheumatoid%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Rheumatoid/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Differentiation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Differentiation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Leukocytes%2c+Mononuclear%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Leukocytes, Mononuclear/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAP+Kinase+Signaling+System%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAP Kinase Signaling System/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mucosa-Associated+Lymphoid+Tissue+Lymphoma+Translocation+1+Protein%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mucosa-Associated+Lymphoid+Tissue+Lymphoma+Translocation+1+Protein%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF-kappa+B%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF-kappa B/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF-kappa+B%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF-kappa B/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoarthritis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoarthritis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Th17+Cells%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Th17 Cells/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Th2+Cells%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Th2 Cells/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Treatment+Outcome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Treatment Outcome</a></li></ul> <a href="javascript:ShowArticleMeSH(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(18);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow19"> <td style="min-width: 40px; text-align: center;"> 19 </td> <td> <div id="citation19" class="article-citation"> <b>Urena F</b>, Ma C, Hoffmann FW, Nunes LGA, Urschitz J, Moisyadi S, Khadka VS, Deng Y, Hoffmann PR. T-cell activation decreases miRNA-15a/16 levels to promote MEK1-ERK1/2-Elk1 signaling and proliferative capacity. <em class='incite-journal-name' onclick='ShowInCiteJournal(12370);'>J Biol Chem</em> 2022;<b>298</b>:101634. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/35085550' target='_blank'>35085550</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861121' target='_blank'>PMC8861121</a> DOI: <a href='https://dx.doi.org/10.1016/j.jbc.2022.101634' target='_blank'>10.1016/j.jbc.2022.101634</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1016%2fj.jbc.2022.101634%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 1</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1016%2fj.jbc.2022.101634')">Impact Index Per Article: 0.5</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.jbc.2022.101634','35085550', 'MAP Kinase Signaling System/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(19);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(19);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(19);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(19);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.jbc.2022.101634' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/86fefaf918554e7caa3fd68e657eab22/PMC8861121.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.1016/j.jbc.2022.101634');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(12370);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/06/2021]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 01/13/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 01/18/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 02/08/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv19" value="10.1016/j.jbc.2022.101634" /> <div style="display: none" id="articleAbstract19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">While miRs have been extensively studied in the context of malignancy and tumor progression, their functions in regulating T-cell activation are less clear. In initial studies, we found reduced levels of miR-15a/16 at 3 to 18 h post-T-cell receptor (TCR) stimulation, suggesting a role for decreased levels of this miR pair in shaping T-cell activation. To further explore this, we developed an inducible miR15a/16 transgenic mouse model to determine how elevating miR-15a/16 levels during early stages of activation would affect T-cell proliferation and to identify TCR signaling pathways regulated by this miR pair. Doxycycline (DOX)-induced expression of miR-15a/16 from 0 to 18 h post-TCR stimulation decreased ex vivo T-cell proliferation as well as in vivo antigen-specific T-cell proliferation. We also combined bioinformatics and proteomics approaches to identify the mitogen-activated protein kinase kinase 1 (MEK1) (Map2k1) as a target of miR-15a/16. MEK1 targeting by miR-15a/16 was confirmed using miR mimics that decreased Map2k1 mRNA containing the 3'-UTR target nucleotide sequence (UGCUGCUA) but did not decrease Map2k1 containing a mutated control sequence (AAAAAAAA). Phosphorylation of downstream signaling molecules, extracellular signal-regulated protein kinase 1/2 (ERK1/2) and Elk1, was also decreased by DOX-induced miR-15a/16 expression. In addition to MEK1, ERK1 was subsequently found to be targeted by miR-15a/16, with DOX-induced miR-15a/16 reducing total ERK1 levels in T cells. These findings show that TCR stimulation reduces miR-15a/16 levels at early stages of T-cell activation to facilitate increased MEK1 and ERK1, which promotes the sustained MEK1-ERK1/2-Elk1 signaling required for optimal proliferation. </div> <a href="javascript:ShowArticleAbstract(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cell+cycle%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cell cycle</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cell+growth%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cell growth</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cell+signaling%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cell signaling</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22miRNA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">miRNA</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mitogen-activated+protein+kinase%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mitogen-activated protein kinase</a></li></ul> <a href="javascript:ShowArticleKeywords(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%223%27+Untranslated+Regions%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">3' Untranslated Regions</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lymphocyte+Activation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lymphocyte Activation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAP+Kinase+Kinase+1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAP Kinase Kinase 1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAP+Kinase+Kinase+1%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAP Kinase Kinase 1/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAP+Kinase+Kinase+1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAP Kinase Kinase 1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAP+Kinase+Signaling+System%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAP Kinase Signaling System/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Antigen%2c+T-Cell%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Antigen, T-Cell/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Antigen%2c+T-Cell%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Antigen, T-Cell/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Antigen%2c+T-Cell%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Antigen, T-Cell/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22T-Lymphocytes%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">T-Lymphocytes/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22T-Lymphocytes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">T-Lymphocytes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ets-Domain+Protein+Elk-1%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ets-Domain Protein Elk-1/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ets-Domain+Protein+Elk-1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ets-Domain Protein Elk-1/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIGMS+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">P20 GM103466 NIGMS NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NCI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">P30 CA071789 NCI NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIGMS+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">P30 GM131944 NIGMS NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIAID+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 AI147496 NIAID NIH HHS</a></li></ul> <a href="javascript:ShowArticleGrant(19);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow20"> <td style="min-width: 40px; text-align: center;"> 20 </td> <td> <div id="citation20" class="article-citation"> <b>Safaee MM</b>, Wang EJ, Jain S, Chen JS, Gill S, Zheng AC, Garcia JH, Beniwal AS, Tran Y, Nguyen AT, Trieu M, Leung K, Wells J, Maclean JM, Wycoff K, Aghi MK. CD97 is associated with mitogenic pathway activation, metabolic reprogramming, and immune microenvironment changes in glioblastoma. <em class='incite-journal-name' onclick='ShowInCiteJournal(20954);'>Sci Rep</em> 2022;<b>12</b>:1464. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/35087132' target='_blank'>35087132</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795421' target='_blank'>PMC8795421</a> DOI: <a href='https://dx.doi.org/10.1038/s41598-022-05259-y' target='_blank'>10.1038/s41598-022-05259-y</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1038%2fs41598-022-05259-y%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 1</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1038%2fs41598-022-05259-y')">Impact Index Per Article: 0.5</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s41598-022-05259-y','35087132', 'MAP Kinase Signaling System/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(20);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(20);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(20);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(20);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1038/s41598-022-05259-y' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/a3af0006776c9d09d77b8478c4cef4f5/PMC8795421.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.1038/s41598-022-05259-y');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(20954);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/30/2021]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 01/03/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/12/2022]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv20" value="10.1038/s41598-022-05259-y" /> <div style="display: none" id="articleAbstract20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Glioblastoma (GBM) is the most common primary brain tumor with a median survival under two years. Using in silico and in vitro techniques, we demonstrate heterogeneous expression of CD97, a leukocyte adhesion marker, in human GBM. Beyond its previous demonstrated role in tumor invasion, we show that CD97 is also associated with upregulation of the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/Erk) and phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) pathways in GBM. While CD97 knockout decreased Akt activation, CD97 targeting did not alter MAPK/Erk activation, did not slow GBM cell proliferation in culture, and increased levels of glycolytic and oxidative phosphorylation metabolites. Treatment with a soluble CD97 inhibitor did not alter activation of the MAPK/Erk and PI3K/Akt pathways. Tumors with high CD97 expression were associated with immune microenvironment changes including increased naïve macrophages, regulatory T cells, and resting natural killer (NK) cells. These data suggest that, while CD97 expression is associated with conflicting effects on tumor cell proliferative and metabolic pathways that overall do not affect tumor cell proliferation, CD97 exerts pro-tumoral effects on the tumor immune microenvironment, which along with the pro-invasive effects of CD97 we previously demonstrated, provides impetus to continue exploring CD97 as a therapeutic target in GBM. </div> <a href="javascript:ShowArticleAbstract(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cns+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cns cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22tumour+heterogeneity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">tumour heterogeneity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22oncogenes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">oncogenes</a></li></ul> <a href="javascript:ShowArticleKeywords(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Activation%2c+Metabolic%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Activation, Metabolic/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antigens%2c+CD%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antigens, CD/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antigens%2c+CD%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antigens, CD/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Neoplasms%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Neoplasms/immunology</a></li><li><a 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center;"> 21 </td> <td> <div id="citation21" class="article-citation"> <b>Zhao BR</b>, Wang XX, Wang XW. Shoc2 recognizes bacterial flagellin and mediates antibacterial Erk/Stat signaling in an invertebrate. <em class='incite-journal-name' onclick='ShowInCiteJournal(19232);'>PLoS Pathog</em> 2022;<b>18</b>:e1010253. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/35073369' target='_blank'>35073369</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812994' target='_blank'>PMC8812994</a> DOI: <a href='https://dx.doi.org/10.1371/journal.ppat.1010253' target='_blank'>10.1371/journal.ppat.1010253</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1371%2fjournal.ppat.1010253%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 6</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1371%2fjournal.ppat.1010253')">Impact Index Per Article: 3.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1371/journal.ppat.1010253','35073369', 'MAP Kinase Signaling System/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(21);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(21);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(21);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1371/journal.ppat.1010253' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/225fe3711da062a4783e69a695cb3da1/PMC8812994.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.1371/journal.ppat.1010253');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(19232);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/15/2021]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 02/03/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 01/06/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/18/2022]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv21" value="10.1371/journal.ppat.1010253" /> <div style="display: none" id="articleAbstract21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <p>Flagellin is a key bacterial virulence factor that can stimulate molecular immune signaling in both animals and plants. The detailed mechanisms of recognizing flagellin and mounting an efficient immune response have been uncovered in vertebrates; however, whether invertebrates can discriminate flagellin remains largely unknown. In the present study, the homolog of human SHOC2 leucine rich repeat scaffold protein in kuruma shrimp (<italic toggle="yes">Marsupenaeus japonicus</italic>), designated MjShoc2, was found to interact with <italic toggle="yes">Vibrio anguillarum</italic> flagellin A (FlaA) using yeast two-hybrid and pull-down assays. MjShoc2 plays a role in antibacterial response by mediating the FlaA-induced expression of certain antibacterial effectors, including lectin and antimicrobial peptide. FlaA challenge, via MjShoc2, led to phosphorylation of extracellular regulated kinase (Erk), and the subsequent activation of signal transducer and activator of transcription (Stat), ultimately inducing the expression of effectors. Therefore, by establishing the FlaA/MjShoc2/Erk/Stat signaling axis, this study revealed a new antibacterial strategy in shrimp, and provides insights into the flagellin sensing mechanism in invertebrates.</p><p>Flagellin sensing has been proven as a general antibacterial strategy. Recognition of bacterial flagellin by the transmembrane receptor toll like receptor 5 (TLR5) leads to the activation of nuclear factor kappa B (NF-κB) pathway and induction of proinflammatory cytokines, while recognition by the intracellular nucleotide-binding leucine-rich (NLR) receptor leads to caspase-activation and cytokines-expression. Although flagellin is an effective immune stimulator that induces antimicrobial peptides in <italic toggle="yes">Drosophila</italic> and in crustaceans, how an invertebrate host senses flagellin and mounts an immune response is poorly understood. Here, we used the flagellin (FlaA) from <italic toggle="yes">Vibrio anguillarum</italic>, a pathogen of shrimp, as a bait protein to screen a yeast two-hybrid library derived from kuruma shrimp (<italic toggle="yes">Marsupenaeus japonicus</italic>). We found a scaffold protein, MjShoc2, able to interact with FlaA. We also found that FlaA could effectively induce the expression of certain recognized antibacterial effectors in shrimp depending on MjShoc2. We revealed that extracellular regulated kinase (Erk) phosphorylation occurred downstream of FlaA/MjShoc2, and led to signal transducer and activator of transcription (Stat) activation, resulting in transcription of certain effectors. Therefore our study provides new insights into the FlaA-induced molecular immunity in invertebrates.</p> <a href="javascript:ShowArticleAbstract(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthropod+Proteins%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthropod Proteins/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Flagellin%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Flagellin/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intracellular+Signaling+Peptides+and+Proteins%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intracellular Signaling Peptides and Proteins/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAP+Kinase+Signaling+System%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAP Kinase Signaling System/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Penaeidae%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Penaeidae/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Penaeidae%2fmicrobiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Penaeidae/microbiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22STAT+Transcription+Factors%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">STAT Transcription Factors/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Vibrio%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Vibrio</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Vibrio+Infections%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Vibrio Infections/immunology</a></li></ul> <a href="javascript:ShowArticleMeSH(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Natural+Science+Foundation+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">National Natural Science Foundation of China</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Key+Research+and+Development+Program+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">National Key Research and Development Program of China</a></li></ul> <a href="javascript:ShowArticleGrant(21);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow22"> <td style="min-width: 40px; text-align: center;"> 22 </td> <td> <div id="citation22" class="article-citation"> <b>Chi MY</b>, Zhang H, Wang YX, Sun XP, Yang QJ, Guo C. Silibinin Alleviates Muscle Atrophy Caused by Oxidative Stress Induced by Cisplatin through ERK/FoxO and JNK/FoxO Pathways. <em>OXIDATIVE MEDICINE AND CELLULAR LONGEVITY</em> 2022;<b>2022</b>:5694223. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/35096269' target='_blank'>35096269</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794676' target='_blank'>PMC8794676</a> DOI: <a href='https://dx.doi.org/10.1155/2022/5694223' target='_blank'>10.1155/2022/5694223</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1155%2f2022%2f5694223%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 2</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1155%2f2022%2f5694223')">Impact Index Per Article: 1.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1155/2022/5694223','35096269', 'MAP Kinase Signaling System/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(22);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(22);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1155/2022/5694223' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/da3442815131b58d4ca715329cbee8da/PMC8794676.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.1155/2022/5694223');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/31/2021]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 12/17/2021]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/31/2021]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 02/06/2023]</span></span> </div> <input type="hidden" name="doiv" id="doiv22" value="10.1155/2022/5694223" /> <div style="display: none" id="articleAbstract22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Cisplatin (DDP), a widely used chemotherapeutic drug in cancer treatment, causes oxidative stress, resulting in cancer cachexia and skeletal muscle atrophy. This study investigated the effects and activity of silibinin (SLI) in reducing DDP-induced oxidative stress and skeletal muscle atrophy in vivo and in vitro. SLI alleviated weight loss, food intake, muscle wasting, adipose tissue depletion, and organ weight reduction induced by DDP and improved the reduction of grip force caused by DDP. SLI can attenuated the increase in reactive oxygen species (ROS) levels, the decrease in Nrf2 expression, the decrease in the fiber cross-sectional area, and changes in fiber type induced by DDP. SLI regulated the ERK/FoxO and JNK/FoxO pathways by downregulating the abnormal increase in ROS and Nrf2 expression in DDP-treated skeletal muscle and C2C12 myotube cells. Further, SLI inhibited the upregulation of MAFbx and Mstn, the downregulation of MyHC and MyoG, the increase in protein degradation, and the decrease of protein synthesis. The protective effects of SLI were reversed by cotreatment with JNK agonists and ERK inhibitors. These results suggest that SLI can reduce DDP-induced skeletal muscle atrophy by reducing oxidative stress and regulating ERK/FoxO and JNK/FoxO pathways. </div> <a href="javascript:ShowArticleAbstract(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antineoplastic+Agents%2fadverse+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antineoplastic Agents/adverse effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antineoplastic+Agents%2c+Phytogenic%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antineoplastic Agents, Phytogenic/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antineoplastic+Agents%2c+Phytogenic%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antineoplastic Agents, Phytogenic/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cisplatin%2fadverse+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cisplatin/adverse effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAP+Kinase+Signaling+System%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAP Kinase Signaling System/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Muscular+Atrophy%2fchemically+induced%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Muscular Atrophy/chemically induced</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Muscular+Atrophy%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Muscular Atrophy/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+Stress%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative Stress/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Silybin%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Silybin/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Silybin%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Silybin/therapeutic use</a></li></ul> <a href="javascript:ShowArticleMeSH(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(22);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow23"> <td style="min-width: 40px; text-align: center;"> 23 </td> <td> <div id="citation23" class="article-citation"> <b>Zhong C</b>, Min K, Zhao Z, Zhang C, Gao E, Huang Y, Zhang X, Baldini M, Roy R, Yang X, Koch WJ, Bennett AM, Yu J. MAP Kinase Phosphatase-5 Deficiency Protects Against Pressure Overload-Induced Cardiac Fibrosis. <em class='incite-journal-name' onclick='ShowInCiteJournal(9345);'>Front Immunol</em> 2021;<b>12</b>:790511. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/34992607' target='_blank'>34992607</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724134' target='_blank'>PMC8724134</a> DOI: <a href='https://dx.doi.org/10.3389/fimmu.2021.790511' target='_blank'>10.3389/fimmu.2021.790511</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.3389%2ffimmu.2021.790511%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 6</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.3389%2ffimmu.2021.790511')">Impact Index Per Article: 2.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3389/fimmu.2021.790511','34992607', 'MAP Kinase Signaling System/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(23);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(23);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(23);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(23);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3389/fimmu.2021.790511' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/3526bc10d5cea490261c61298cda828b/PMC8724134.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.3389/fimmu.2021.790511');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9345);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/06/2021]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/30/2021]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/13/2022]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv23" value="10.3389/fimmu.2021.790511" /> <div style="display: none" id="articleAbstract23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Cardiac fibrosis, a pathological condition due to excessive extracellular matrix (ECM) deposition in the myocardium, is associated with nearly all forms of heart disease. The processes and mechanisms that regulate cardiac fibrosis are not fully understood. In response to cardiac injury, macrophages undergo marked phenotypic and functional changes and act as crucial regulators of myocardial fibrotic remodeling. Here we show that the mitogen-activated protein kinase (MAPK) phosphatase-5 (MKP-5) in macrophages is involved in pressure overload-induced cardiac fibrosis. Cardiac pressure overload resulting from transverse aortic constriction (TAC) leads to the upregulation of Mkp-5 gene expression in the heart. In mice lacking MKP-5, p38 MAPK and JNK were hyperactivated in the heart, and TAC-induced cardiac hypertrophy and myocardial fibrosis were attenuated. MKP-5 deficiency upregulated the expression of the ECM-degrading matrix metalloproteinase-9 (Mmp-9) in the Ly6Clow (M2-type) cardiac macrophage subset. Consistent with in vivo findings, MKP-5 deficiency promoted MMP-9 expression and activity of pro-fibrotic macrophages in response to IL-4 stimulation. Furthermore, using pharmacological inhibitors against p38 MAPK, JNK, and ERK, we demonstrated that MKP-5 suppresses MMP-9 expression through a combined effect of p38 MAPK/JNK/ERK, which subsequently contributes to the inhibition of ECM-degrading activity. Taken together, our study indicates that pressure overload induces MKP-5 expression and facilitates cardiac hypertrophy and fibrosis. MKP-5 deficiency attenuates cardiac fibrosis through MAPK-mediated regulation of MMP-9 expression in Ly6Clow cardiac macrophages. </div> <a href="javascript:ShowArticleAbstract(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAPK+signaling%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAPK signaling</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MKP-5%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MKP-5</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cardiac+fibrosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22American+Heart+Association%5cn%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">American Heart Association </a></li></ul> <a href="javascript:ShowArticleGrant(23);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow24"> <td style="min-width: 40px; text-align: center;"> 24 </td> <td> <div id="citation24" class="article-citation"> <b>Simon M</b>, Lücht C, Hosp I, Zhao H, Wu D, Heidecke H, Witowski J, Budde K, Riemekasten G, Catar R. Autoantibodies from Patients with Scleroderma Renal Crisis Promote PAR-1 Receptor Activation and IL-6 Production in Endothelial Cells. <em class='incite-journal-name' onclick='ShowInCiteJournal(11724);'>Int J Mol Sci</em> 2021;<b>22</b>:11793. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/34769227' target='_blank'>34769227</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584031' target='_blank'>PMC8584031</a> DOI: <a href='https://dx.doi.org/10.3390/ijms222111793' target='_blank'>10.3390/ijms222111793</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.3390%2fijms222111793%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 13</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.3390%2fijms222111793')">Impact Index Per Article: 4.3</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3390/ijms222111793','34769227', 'MAP Kinase Signaling System/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(24);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(24);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(24);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(24);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3390/ijms222111793' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/78f4dcc47f9c3d58183553312d665140/PMC8584031.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.3390/ijms222111793');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11724);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 09/21/2021]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/19/2021]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/28/2021]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 02/07/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv24" value="10.3390/ijms222111793" /> <div style="display: none" id="articleAbstract24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Scleroderma renal crisis (SRC) is a life-threatening complication of systemic sclerosis (SSc). Autoantibodies (Abs) against endothelial cell antigens have been implicated in SSc and SRC. However, their detailed roles remain poorly defined. Pro-inflammatory cytokine interleukin-6 (IL-6) has been found to be increased in SSc, but its role in SRC is unclear. Here, we aimed to determine how the autoantibodies from patients with SSc and SRC affect IL-6 secretion by micro-vascular endothelial cells (HMECs). </div><div class="abstract-label">METHODS</div><div class="abstract-content">Serum IgG fractions were isolated from either SSc patients with SRC (n = 4) or healthy individuals (n = 4) and then each experiment with HMECs was performed with SSc-IgG from a separate patient or separate healthy control. IL-6 expression and release by HMECs was assessed by quantitative reverse transcription and quantitative PCR (RT-qPCR) and immunoassays, respectively. The mechanisms underlying the production of IL-6 were analyzed by transient HMEC transfections with IL-6 promoter constructs, electrophoretic mobility shift assays, Western blots and flow cytometry. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Exposure of HMECs to IgG from SSc patients, but not from healthy controls, resulted in a time- and dose-dependent increase in IL-6 secretion, which was associated with increased AKT, p70S6K, and ERK1/2 signalling, as well as increased c-FOS/AP-1 transcriptional activity. All these effects could be reduced by the blockade of the endothelial PAR-1 receptor and/or c-FOS/AP-1silencing. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">Autoantibodies against PAR-1 found in patients with SSc and SRC induce IL-6 production by endothelial cells through signalling pathways controlled by the AP-1 transcription factor. These observations offer a greater understanding of adverse endothelial cell responses to autoantibodies present in patients with SRC. </div> <a href="javascript:ShowArticleAbstract(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22IL-6%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">IL-6</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22PAR-1+receptor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PAR-1 receptor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22autoantibodies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">autoantibodies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22scleroderma+renal+crisis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">scleroderma renal crisis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22systemic+sclerosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">systemic sclerosis</a></li></ul> <a href="javascript:ShowArticleKeywords(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autoantibodies%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autoantibodies/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endothelial+Cells%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endothelial Cells/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Interleukin-6%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Interleukin-6/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kidney+Diseases%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kidney Diseases/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAP+Kinase+Signaling+System%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAP Kinase Signaling System/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+PAR-1%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, PAR-1/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Scleroderma%2c+Systemic%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Scleroderma, Systemic/immunology</a></li></ul> <a href="javascript:ShowArticleMeSH(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Deutsche+Forschungsgemeinschaft%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">394046635 Deutsche Forschungsgemeinschaft</a></li></ul> <a href="javascript:ShowArticleGrant(24);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow25"> <td style="min-width: 40px; text-align: center;"> 25 </td> <td> <div id="citation25" class="article-citation"> <b>Häger SC</b>, Dias C, Sønder SL, Olsen AV, da Piedade I, Heitmann ASB, Papaleo E, Nylandsted J. Short-term transcriptomic response to plasma membrane injury. <em class='incite-journal-name' onclick='ShowInCiteJournal(20954);'>Sci Rep</em> 2021;<b>11</b>:19141. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/34580330' target='_blank'>34580330</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476590' target='_blank'>PMC8476590</a> DOI: <a href='https://dx.doi.org/10.1038/s41598-021-98420-y' target='_blank'>10.1038/s41598-021-98420-y</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1038%2fs41598-021-98420-y%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 4</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1038%2fs41598-021-98420-y')">Impact Index Per Article: 1.3</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s41598-021-98420-y','34580330', 'MAP Kinase Signaling System/immunology')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(25);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(25);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(25);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1038/s41598-021-98420-y' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/2bf17cbfa1acba0a3e5b041cf23a1bbc/PMC8476590.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.1038/s41598-021-98420-y');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(20954);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/01/2021]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/06/2021]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/13/2022]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv25" value="10.1038/s41598-021-98420-y" /> <div style="display: none" id="articleAbstract25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Plasma membrane repair mechanisms are activated within seconds post-injury to promote rapid membrane resealing in eukaryotic cells and prevent cell death. However, less is known about the regeneration phase that follows and how cells respond to injury in the short-term. Here, we provide a genome-wide study into the mRNA expression profile of MCF-7 breast cancer cells exposed to injury by digitonin, a mild non-ionic detergent that permeabilizes the plasma membrane. We focused on the early transcriptional signature and found a time-dependent increase in the number of differentially expressed (> twofold, P < 0.05) genes (34, 114 and 236 genes at 20-, 40- and 60-min post-injury, respectively). Pathway analysis highlighted a robust and gradual three-part transcriptional response: (1) prompt activation of immediate-early response genes, (2) activation of specific MAPK cascades and (3) induction of inflammatory and immune pathways. Therefore, plasma membrane injury triggers a rapid and strong stress and immunogenic response. Our meta-analysis suggests that this is a conserved transcriptome response to plasma membrane injury across different cell and injury types. Taken together, our study shows that injury has profound effects on the transcriptome of wounded cells in the regeneration phase (subsequent to membrane resealing), which is likely to influence cellular status and has been previously overlooked. </div> <a href="javascript:ShowArticleAbstract(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cell+biology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cell biology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22computational+biology+and+bioinformatics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">computational biology and bioinformatics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22genetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22molecular+biology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">molecular biology</a></li></ul> <a href="javascript:ShowArticleKeywords(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAP+Kinase+Signaling+System%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAP Kinase Signaling System/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAP+Kinase+Signaling+System%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAP Kinase Signaling System/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MCF-7+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MCF-7 Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA-Seq%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA-Seq</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Regeneration%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Regeneration/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Regeneration%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Regeneration/immunology</a></li></ul> <a href="javascript:ShowArticleMeSH(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(25);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> </tbody></table> <div class="search-pager-container"> <div class="dxpLite_MetropolisBlue" id="RootHolder_SearchResultPager" style="margin-top: 20px; margin-bottom: 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style="text-align:Center;vertical-align:Top;"><span id="RootHolder_LeftLoadingPanel_TL">Loading…</span></td> </tr> </table><div id="RootHolder_LeftLoadingPanel_LD" class="dxlpLoadingDiv_MetropolisBlue dxlpControl_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1950550554" type="text/javascript">  </script> <div id="RootHolder_articleCitationPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:450px;width:600px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam"></span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content">    </div> </div> </div> </div><div id="RootHolder_articleCitationPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_articleCitationPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleCitationPopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleCitationPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1115091042" type="text/javascript">  </script> <div id="RootHolder_chartPopupControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:1000px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_chartPopupControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam"></span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content" style="overflow-x:hidden;overflow-y:scroll;">    </div> </div> </div> </div><div id="RootHolder_chartPopupControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_chartPopupControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_chartPopupControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_chartPopupControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_420552910" type="text/javascript">  </script> <div id="RootHolder_pcImportArticlesControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:50px;width:50px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_pcImportArticlesControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Import Articles</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="RootHolder_pcImportArticlesControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcImportArticlesControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcImportArticlesControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcImportArticlesControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_365297802" type="text/javascript">  </script> <div id="RootHolder_pcEditArticleControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_pcEditArticleControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Edit My Journal Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content" style="overflow-x:hidden;overflow-y:scroll;">    </div> </div> </div> </div><div id="RootHolder_pcEditArticleControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcEditArticleControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcEditArticleControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcEditArticleControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_298765222" type="text/javascript">  </script> <div id="RootHolder_userIndexComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:400px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Article Influence Index</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle2">Article Influence Index</span></b> </p> <p> Total Citations in Crossref ÷ Total Articles = <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle3">Article Influence Index</span><sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="RootHolder_userIndexComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_userIndexComputePopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_userIndexComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1286575841" type="text/javascript">  </script> <div id="RootHolder_articleExportPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:280px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow" style="font-size:11pt;"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_articleExportPopup_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Export Articles to File</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="dxtcLite_MetropolisBlue dxtcSys dxtc-init dxtc-top dxtc-pc" id="RootHolder_articleExportPopup_ExportFilePageControl" style="width:100%;"> <ul class="dxtc-strip dxtc-row dxtc-stripContainer"> <li class="dxtc-leftIndent"> </li><li class="dxtc-tab dxtc-lead" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-activeTab dxtc-lead"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-spacer"> </li><li class="dxtc-tab dxtc-last"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-activeTab dxtc-last" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-rightIndent"> </li> </ul><div class="dxtc-content"> <div> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_SearchTermText1">MAP Kinase Signaling System/immunology (494 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:5px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_1662381219" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailEndIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" value="494" type="text" /></td> </tr> </table><script id="dxss_616434442" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_1167331127" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_54524200" type="text/javascript">  </script><script id="dxss_1678130197" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" style="font-weight:bold;">JCR Year:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" type="hidden" value="2023" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" value="2023" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2023</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2022</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2021</td> </tr> </table> </div></td> </tr> </table><script id="dxss_830317689" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_167955898" type="text/javascript">  </script><script id="dxss_2013408041" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1062639383" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_104403608" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1973673553" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_6" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLTSys dxflItemSys dxflCheckBoxWithTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" style="font-weight:bold;">Record Content:</label></td> </tr><tr> <td class="dxflNestedControlCell_MetropolisBlue"> <table> <tr> <td style="vertical-align: middle; padding: 5px;"> <table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields" style="color:#BD4100;"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$cbSelectAllFields" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label>Select All Fields</label></td> </tr> </table><script id="dxss_1176833720" type="text/javascript">  </script> </td> </tr> <tr> <td style="padding: 5px;"> <table class="dxeCheckBoxList_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields" style="width:100%;border-collapse:separate;"> <tr> <td class="dxe"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields" /><table style="width:100%;"> <tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB0" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Author(s)</label></td> </tr> </table><script id="dxss_771536870" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB1" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Title</label></td> </tr> </table><script id="dxss_1086331335" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB2" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Keywords</label></td> </tr> </table><script id="dxss_1308541020" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB3" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">MESH Headings</label></td> </tr> </table><script id="dxss_896786043" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB4" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Journal Title</label></td> </tr> </table><script id="dxss_450242410" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB5" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Year</label></td> </tr> </table><script id="dxss_765036875" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB6" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Type</label></td> </tr> </table><script id="dxss_1629835480" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB7" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Language</label></td> </tr> </table><script id="dxss_1218080503" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB8" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Published Date</label></td> </tr> </table><script id="dxss_1428514578" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB9" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author</label></td> </tr> </table><script id="dxss_1113720113" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB10" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author’s Affiliations</label></td> </tr> </table><script id="dxss_310841941" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB11" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author</label></td> </tr> </table><script id="dxss_1301541094" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB12" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author’s Affiliations</label></td> </tr> </table><script id="dxss_675718561" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB13" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Email</label></td> </tr> </table><script id="dxss_2006865700" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB14" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">All Authors's Affiliations</label></td> </tr> </table><script id="dxss_1204905793" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB15" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Grant</label></td> </tr> </table><script id="dxss_407477242" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB16" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">ISSN</label></td> </tr> </table><script id="dxss_218345291" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB17" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Publisher</label></td> </tr> </table><script id="dxss_1394037744" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB18" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexing / Abstracting</label></td> </tr> </table><script id="dxss_319681069" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB19" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Factor</label></td> </tr> </table><script id="dxss_1292701966" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB20" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">JCR Quartile</label></td> </tr> </table><script id="dxss_1844280938" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB21" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Index Per Article</label></td> </tr> </table><script id="dxss_838303323" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB22" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Category</label></td> </tr> </table><script id="dxss_1464125856" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB23" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Times Cited in RCA</label></td> </tr> </table><script id="dxss_148257179" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB24" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Peer-Reviewed Journal</label></td> </tr> </table><script id="dxss_950217086" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB25" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Open Access</label></td> </tr> </table><script id="dxss_1732367175" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB26" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">DOI</label></td> </tr> </table><script id="dxss_1936777588" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB27" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">PMID</label></td> </tr> </table><script id="dxss_745806673" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB28" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Citation</label></td> </tr> </table><script id="dxss_1835441810" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB29" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexed in RCA</label></td> </tr> </table><script id="dxss_847142451" type="text/javascript">  </script></td><td></td><td></td> </tr> </table></td> </tr> </table><script id="dxss_1169734383" type="text/javascript">  </script> </td> </tr> </table> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_7" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportedDetailFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_1198171345" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_1960175520" type="text/javascript">  </script> </div> </div><div style="display:none;"> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_SearchTermText2">MAP Kinase Signaling System/immunology (494 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:10px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_814491935" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportEndSIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" value="494" type="text" /></td> </tr> </table><script id="dxss_1331245653" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:10px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_2046065225" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_1926633208" type="text/javascript">  </script><script id="dxss_228619664" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:20px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" type="hidden" value="1" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" value="Excel" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1509722775" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_960798088" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_835950349" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportedFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_308093146" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_424125632" type="text/javascript">  </script> </div> </div> </div> </div><b class="dx-clear"></b><table id="RootHolder_articleExportPopup_ExportFilePageControl_LP" class="dxtcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_TL">Loading…</span></td> </tr> </table><script id="dxss_2124675053" type="text/javascript">  </script> </div> </div><div class="dxpc-footer"> <div class="popup-footer-button-container"> <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles_I" class="dxb-hb" value="Export" type="submit" name="ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnExportArticles" /><span class="dx-vam">Export</span> </div> </div><script id="dxss_77486387" type="text/javascript">  </script>    <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnCancel" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_articleExportPopup_TPCFm1_btnCancel_I" class="dxb-hb" value="Cancel" type="submit" name="ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnCancel" /><span class="dx-vam">Cancel</span> </div> </div><script id="dxss_2118985763" type="text/javascript">  </script> </div> </div> </div> </div><div id="RootHolder_articleExportPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_articleExportPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="font-size:11pt;left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="font-size:11pt;padding-left:0px;"><span id="RootHolder_articleExportPopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_578446409" type="text/javascript">  </script> </div> <div class="bottom-part cl"> © 2004-2024 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA </div> <div class="scroll"> <a href="#top" target="_self"> <img src="/Contents/Images/backtop3.png" /> </a> </div> <div id="categorySelectorPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Select the Category</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="categorySelectorPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="categorySelectorPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="categorySelectorPopup_TL">Loading…</span></td> </tr> </table><div id="categorySelectorPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_166253781" type="text/javascript">  </script> <div id="pcLoginPopUp_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:700px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="pcLoginPopUp_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="pcLoginPopUp_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="pcLoginPopUp_TL">Loading…</span></td> </tr> </table><div id="pcLoginPopUp_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_430910140" type="text/javascript">  </script> <div id="aiComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:300px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Impact Index Per Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for Impact Index Per Article</b> </p> <p> Times Cited ÷ Number of Years = Impact Index Per Article<sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="aiComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="aiComputePopup_TL">Loading…</span></td> </tr> </table><div id="aiComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_698179129" type="text/javascript">  </script> <script type="text/javascript"> //<![CDATA[ var callBackFrameUrl='/WebResource.axd?d=beToSAE3vdsL1QUQUxjWdX-3aFLejnBliGvqSCZYULGFdxZmRlcJcqs71AKVNTQEXljNmd0slFkUZ_AFaCke4Q2&t=638628207619783110'; WebForm_InitCallback();//]]> </script> </form> </body> </html>