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Advances in the treatment of autism spectrum disorder: Wharton jelly mesenchymal stem cell transplantation. <em class='incite-journal-name' onclick='ShowInCiteJournal(23486);'>World J Methodol</em> 2025;<b>15</b>:95857. [DOI: <a href='https://dx.doi.org/10.5662/wjm.v15.i1.95857' target='_blank'>10.5662/wjm.v15.i1.95857</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.5662/wjm.v15.i1.95857','', 'Inflammation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(1);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(1);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.wjgnet.com/2222-0682/full/v15/i1/95857.htm' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.f6publishing.com/forms/main/DownLoadFile.aspx?Type=Digital&TypeId=1&id=10.5662%2fwjm.v15.i1.95857&FilePath=25B8AB6D8409B70C78405EC2AAF0AFF89F007B01720818148C8B83627AC0A7CAF32049277570BA149A1EF22A6A6D9F42A9F15E003AF15D9253CE4B9E533E0A4A83CC018C99EE097E' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(23486);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.f6publishing.com/' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 06/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/29/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv1" value="10.5662/wjm.v15.i1.95857" /> <div style="display: none" id="articleAbstract1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="article-section-title-1">BACKGROUND</div><p>Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with multifaceted origins. In recent studies, neuroinflammation and immune dysregulation have come to the forefront in its pathogenesis. There are studies suggesting that stem cell therapy may be effective in the treatment of ASD.</p> <div class="article-section-title-1">AIM</div><p>To evolve the landscape of ASD treatment, focusing on the potential benefits and safety of stem cell transplantation.</p> <div class="article-section-title-1">METHODS</div><p>A detailed case report is presented, displaying the positive outcomes observed in a child who underwent intra<Hypen />thecal and intravenous Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) transplantation combined with neurorehabilitation.</p> <div class="article-section-title-1">RESULTS</div><p>The study demonstrates a significant improvement in the child’s functional outcomes (Childhood Autism Rating Scale, Denver 2 Developmental Screening Test), especially in language and gross motor skills. No serious side effects were encountered during the 2-year follow-up.</p> <div class="article-section-title-1">CONCLUSION</div><p>The findings support the safety and effectiveness of WJ-MSC transplantation in managing ASD.</p> <a href="javascript:ShowArticleAbstract(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autism+spectrum+disorder%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autism spectrum disorder</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurorehabilitation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurorehabilitation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stem+cell+transplantation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stem cell transplantation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Wharton+jelly+mesenchymal+stem+cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Wharton jelly mesenchymal stem cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation</a></li></ul> <a href="javascript:ShowArticleKeywords(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(1);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow2"> <td style="min-width: 40px; text-align: center;"> 2 </td> <td> <div id="citation2" class="article-citation"> <b>Liu L</b>, Ding M, Zheng M, Xu G, Gao L, Yang W, Wei Z, Shang J, Wang L, Wang H, Gao F. Transformable peptide blocks NF-κB/IκBα pathway through targeted coating IκBα against rheumatoid arthritis. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122839. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39288618' target='_blank'>39288618</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122839' target='_blank'>10.1016/j.biomaterials.2024.122839</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122839','39288618', 'Inflammation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(2);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(2);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(2);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122839' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/28/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/19/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv2" value="10.1016/j.biomaterials.2024.122839" /> <div style="display: none" id="articleAbstract2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Rheumatoid arthritis (RA) is an autoimmune disease characterized by destructive effects. Although current therapies utilizing antibodies against inflammatory cytokines have shown some success, the inhibition of a single inflammatory molecule may not suffice to impede the progression of RA due to the intricate pathogenesis involving multiple molecules. In this study, we have developed an intelligent transformable peptide, namely BP-FFVLK-DSGLDSM (BFD). BFD has the ability to self-assemble into spherical nanoparticles in water or in the blood circulation to facilitate their delivery and distribution. When endocytosed into immune cells, BFD can identify and attach to phosphorylation sites on IκBα and in situ transform into a nanofibrous network coating NF-κB/IκBα complexes, blocking the phosphorylation and degradation of IκBα. As a result, BFD enables decreasing expression of proinflammatory mediators. In the present study, we demonstrate that BFD exhibits notable efficacy in alleviating arthritis-related manifestations, such as joints and tissues swelling, as well as bone and cartilage destruction on the collagen-induced arthritis (CIA) rat model. The investigation of intracellular biodistribution, phosphorylation of IκBα, and cytokine detection in culture medium supernatant, joint tissue, and serum exhibits strong associations with therapeutic outcomes. The utilization of transformable peptide presents a novel approach for the management of inflammatory diseases. </div> <a href="javascript:ShowArticleAbstract(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF-%ce%baB%2fI%ce%baB%ce%b1+pathway%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF-κB/IκBα pathway</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phosphorylation+of+I%ce%baB%ce%b1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phosphorylation of IκBα</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rheumatoid+arthritis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rheumatoid arthritis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transformable+peptide%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transformable peptide</a></li></ul> <a href="javascript:ShowArticleKeywords(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF-kappa+B%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF-kappa B/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Rheumatoid%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Rheumatoid/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Rheumatoid%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Rheumatoid/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF-KappaB+Inhibitor+alpha%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF-KappaB Inhibitor alpha/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Peptides%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Peptides/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phosphorylation%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phosphorylation/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Experimental%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Experimental/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Experimental%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Experimental/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Experimental%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Experimental/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cytokines%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cytokines/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RAW+264.7+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RAW 264.7 Cells</a></li></ul> <a href="javascript:ShowArticleMeSH(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(2);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow3"> <td style="min-width: 40px; text-align: center;"> 3 </td> <td> <div id="citation3" class="article-citation"> <b>Ben Amara H</b>, Martinez DC, Iskhakova K, Emanuelsson L, Norlindh B, Johansson Loo A, Wieland DCF, Zeller-Plumhoff B, Willumeit-Römer R, Plocinski T, Swieszkowski W, Shah FA, Palmquist A, Omar O, Thomsen P. Multifaceted bone response to immunomodulatory magnesium implants: Osteopromotion at the interface and adipogenesis in the bone marrow. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122779. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39305536' target='_blank'>39305536</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122779' target='_blank'>10.1016/j.biomaterials.2024.122779</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122779','39305536', 'Inflammation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(3);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(3);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(3);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122779' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/10/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv3" value="10.1016/j.biomaterials.2024.122779" /> <div style="display: none" id="articleAbstract3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Orthopedic implants made of biodegradable magnesium (Mg) provide an alternative to nondegradable implants for fracture repair. Widely reported to be pro-osteogenic, Mg implants are also believed to be anti-inflammatory and anti-osteoclastic, but this is difficult to reconcile with the early clinical inflammation observed around these implants. Here, by surveying implant healing in a rat bone model, we determined the cellular responses and structural assembly of bone correlated with the surface changes of Mg implants inherent in degradation. We show that, compared to titanium, both high-purity (99.998 %) and clinical-grade, rare earth-alloyed (MgYREZr) Mg implants create an initial, transient proinflammatory environment that facilitates inducible nitric oxide synthase-mediated macrophage polarization, osteoclastogenesis, and neoangiogenesis programs. While this immunomodulation subsequently reinforces reparative osteogenesis at the surface of both Mg implants, the faster degradation of high-purity Mg implants, but not MgYREZr implants, elicits a compositional alteration in the interfacial bone and a previously unknown proadipogenic response with persistent low-grade inflammation in the surrounding bone marrow. Beyond the need for rigorous tailoring of Mg implants, these data highlight the need to closely monitor osseointegration not only at the immediate implant surface but also in the peri-implant bone and adjacent bone marrow. </div> <a href="javascript:ShowArticleAbstract(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adipose+tissue%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adipose tissue</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biodegradable+implants%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biodegradable implants</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone-implant+interface%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone-implant interface</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Magnesium%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Magnesium</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osseointegration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osseointegration</a></li></ul> <a href="javascript:ShowArticleKeywords(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Magnesium%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Magnesium/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Magnesium%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Magnesium/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adipogenesis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adipogenesis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteogenesis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteogenesis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Sprague-Dawley%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Sprague-Dawley</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Marrow%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Marrow/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone-Implant+Interface%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone-Implant Interface</a></li></ul> <a href="javascript:ShowArticleMeSH(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(3);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow4"> <td style="min-width: 40px; text-align: center;"> 4 </td> <td> <div id="citation4" class="article-citation"> <b>Raddatz MA</b>, Pershad Y, Parker AC, Bick AG. Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Health. <em class='incite-journal-name' onclick='ShowInCiteJournal(4503);'>Cardiol Clin</em> 2025;<b>43</b>:13-23. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39551555' target='_blank'>39551555</a> DOI: <a href='https://dx.doi.org/10.1016/j.ccl.2024.08.004' target='_blank'>10.1016/j.ccl.2024.08.004</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.ccl.2024.08.004','39551555', 'Inflammation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(4);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(4);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(4);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.ccl.2024.08.004' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4503);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.cardiology.theclinics.com/action/ecommerce' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/19/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv4" value="10.1016/j.ccl.2024.08.004" /> <div style="display: none" id="articleAbstract4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related phenomenon in which somatic mutations lead to clonal expansion of hematopoietic stem cells without the development of hematologic abnormalities. A growing body of literature demonstrates an association between CHIP and cardiovascular disease. This pathophysiology demonstrates a novel connection between global inflammation and cardiovascular morbidity. While there is limited consensus addressing the cardiovascular care of these patients, risk factor optimization and disease surveillance are advisable. Investigation into possible therapies is ongoing and provides promise for the treatment of inflammation contributing to cardiovascular disease in patients with and without CHIP. </div> <a href="javascript:ShowArticleAbstract(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Atherosclerosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Atherosclerosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cardiovascular+genetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cardiovascular genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Clonal+hematopoiesis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Clonal hematopoiesis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation</a></li></ul> <a href="javascript:ShowArticleKeywords(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Clonal+Hematopoiesis%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Clonal Hematopoiesis/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cardiovascular+Diseases%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cardiovascular Diseases/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cardiovascular+Diseases%2fphysiopathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cardiovascular Diseases/physiopathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mutation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mutation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hematopoietic+Stem+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hematopoietic Stem Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Risk+Factors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Risk Factors</a></li></ul> <a href="javascript:ShowArticleMeSH(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(4);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow5"> <td style="min-width: 40px; text-align: center;"> 5 </td> <td> <div id="citation5" class="article-citation"> <b>Furuichi T</b>, Hirai H, Kitahara T, Bun M, Ikuta M, Ukon Y, Furuya M, Oreffo RO, Janeczek AA, Dawson JI, Okada S, Kaito T. Nanoclay gels attenuate BMP2-associated <span class="highlight-field">inflammation</span> and promote chondrogenesis to enhance BMP2-spinal fusion. <em class='incite-journal-name' onclick='ShowInCiteJournal(3271);'>Bioact Mater</em> 2025;<b>44</b>:474-487. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39559426' target='_blank'>39559426</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570687' target='_blank'>PMC11570687</a> DOI: <a href='https://dx.doi.org/10.1016/j.bioactmat.2024.10.027' target='_blank'>10.1016/j.bioactmat.2024.10.027</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.bioactmat.2024.10.027','39559426', 'Inflammation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(5);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(5);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.bioactmat.2024.10.027' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/e8f582eb87e67686105764f8dd3ada08/main.PMC11570687.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.1016/j.bioactmat.2024.10.027');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3271);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/20/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv5" value="10.1016/j.bioactmat.2024.10.027" /> <div style="display: none" id="articleAbstract5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Bone morphogenetic protein 2 (BMP2) is clinically applied for treating intractable fractures and promoting spinal fusion because of its osteogenic potency. However, adverse effects following the release of supraphysiological doses of BMP2 from collagen carriers are widely reported. Nanoclay gel (NC) is attracting attention as a biomaterial, given the potential for localized efficacy of administered agents. However, the efficacy and mechanism of action of NC/BMP2 remain unclear. This study explored the efficacy of NC as a BMP2 carrier in bone regeneration and the enhancement mechanism. Subfascial implantation of NC containing BMP2 elicited superior bone formation compared with collagen sponge (CS). Cartilage was uniformly formed inside the NC, whereas CS formed cartilage only on the perimeter. Additionally, CS induced a dose-dependent inflammatory response around the implantation site, whereas NC induced a minor response, and inflammatory cells were observed inside the NC. In a rat spinal fusion model, NC promoted high-quality bony fusion compared to CS. In vitro, NC enhanced chondrogenic and osteogenic differentiation of hBMSCs and ATDC5 cells while inhibiting osteoclastogenesis. Overall, NC/BMP2 facilitates spatially controlled, high-quality endochondral bone formation without BMP2-induced inflammation and promotes high-density new bone, functioning as a next-generation BMP2 carrier. </div> <a href="javascript:ShowArticleAbstract(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+morphogenetic+protein+2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone morphogenetic protein 2</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+tissue+engineering%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone tissue engineering</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endochondral+ossification%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endochondral ossification</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoclay%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoclay</a></li></ul> <a href="javascript:ShowArticleKeywords(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(5);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow6"> <td style="min-width: 40px; text-align: center;"> 6 </td> <td> <div id="citation6" class="article-citation"> <b>Graça SC</b>, Bustelli IB, Santos ÉVD, Fernandes CG, Lanaro R, Stilhano RS, Linardi A, Caetano AL. Banisteriopsis caapi extract: Implications for neuroinflammatory pathways in Locus coeruleus lesion rodent model. <em>JOURNAL OF ETHNOPHARMACOLOGY</em> 2025;<b>337</b>:118775. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39244172' target='_blank'>39244172</a> DOI: <a href='https://dx.doi.org/10.1016/j.jep.2024.118775' target='_blank'>10.1016/j.jep.2024.118775</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.jep.2024.118775','39244172', 'Inflammation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(6);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(6);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(6);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.jep.2024.118775' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/09/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv6" value="10.1016/j.jep.2024.118775" /> <div style="display: none" id="articleAbstract6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">ETHNOPHARMACOLOGY RELEVANCE</div><div class="abstract-content">Ayahuasca is a beverage obtained from the decoctions of Banisteriopsis caapi (Spruce ex Griseb.) Morton and Psychotria viridis Ruiz & Pav., used throughout the Amazon as a medicinal beverage for healing and spiritual exploration. The Banisteriopsis caapi extract consists of harmine, harmaline, and tetrahydroharmine (THH); which inhibit the isoforms of monoamine oxidase A and B. In the central nervous system (CNS), it can increase the norepinephrine (NE) concentration, produced in the Locus coeruleus (LC), reducing inflammation that is associated with some neurological disease, such as Parkinson's disease and Alzheimer's disease. </div><div class="abstract-label">AIM OF THE STUDY</div><div class="abstract-content">evaluate the effects of treatment with B. caapi extract on the neuroinflammatory profile in animals with selective LC lesions. </div><div class="abstract-label">MATERIAL AND METHODS</div><div class="abstract-content">male Wistar rats with LC lesions induced by 6-hydroxydopamine were treated with B. caapi extract. Subsequently, behavioral tests were conducted, including the elevated plus maze, rotarod, and open field. Tyrosine hydroxylase positive (TH+) neurons and IBA-1 positive microglia were quantified from the LC inflammatory markers and free radical products were assessed. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Both 6-Hydroxydopamine hydrochloride and the Banisteriopsis caapi extract causes reduction of LC neurons, at the concentration and frequency used. The LC depletion and the treatment of B. caapi extract interfere with locomotion. B. caapi extract and the LC lesion increased the number and activation of inflammatory cells, such as microglia. B. caapi extract decreases IL-10 in the hippocampus and BDNF gene expression. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">This study suggests that B. caapi extract (at the concentration and frequency used) promotes noradrenergic neuron depletion and creates a proinflammatory environment in the CNS. </div> <a href="javascript:ShowArticleAbstract(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Banisteriopsis+caapi%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Banisteriopsis caapi</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Locus+coeruleus%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Locus coeruleus</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurodegeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurodegeneration</a></li></ul> <a href="javascript:ShowArticleKeywords(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Plant+Extracts%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Plant Extracts/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Plant+Extracts%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Plant Extracts/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Wistar%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Wistar</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Locus+Coeruleus%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Locus Coeruleus/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Locus+Coeruleus%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Locus Coeruleus/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Banisteriopsis%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Banisteriopsis/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuroinflammatory+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuroinflammatory Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Behavior%2c+Animal%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Behavior, Animal/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anti-Inflammatory+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anti-Inflammatory Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anti-Inflammatory+Agents%2fisolation+%26amp%3b+purification%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anti-Inflammatory Agents/isolation & purification</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Maze+Learning%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Maze Learning/drug effects</a></li></ul> <a href="javascript:ShowArticleMeSH(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(6);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow7"> <td style="min-width: 40px; text-align: center;"> 7 </td> <td> <div id="citation7" class="article-citation"> <b>Dai ZQ</b>, Guo ZQ, Zhang T, Chu YF, Yan Y, Gao F, Li SL, Gu YH, Jiao JY, Lin YX, Zhao SW, Xu B, Lei HM. Integrating network pharmacology and transcriptomics to study the potential mechanism of Jingzhi Niuhuang Jiedu tablet in rats with accumulation of heat in the lungs and stomach. <em>JOURNAL OF ETHNOPHARMACOLOGY</em> 2025;<b>337</b>:118890. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39366495' target='_blank'>39366495</a> DOI: <a href='https://dx.doi.org/10.1016/j.jep.2024.118890' target='_blank'>10.1016/j.jep.2024.118890</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.jep.2024.118890','39366495', 'Inflammation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(7);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(7);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(7);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.jep.2024.118890' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/06/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv7" value="10.1016/j.jep.2024.118890" /> <div style="display: none" id="articleAbstract7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">ETHNOPHARMACOLOGICAL RELEVANCE</div><div class="abstract-content">Accumulation of heat in the lungs and stomach (AHLS) is an important syndrome within the realm of traditional Chinese medicine (TCM). It is the fundamental reason behind numerous illnesses, including mouth ulcers, dermatological conditions, acne, and pharyngitis. Jingzhi Niuhuang Jiedu tablet (JN) serves as the representative prescription for treatment of AHLS clinically. However, the effective components and mechanism of JN's impact on AHLS remain unexplored. </div><div class="abstract-label">AIM OF THE STUDY</div><div class="abstract-content">The objective of this research was to analyze the effective components of JN and investigate the therapeutic effect and potential mechanism of JN on AHLS. </div><div class="abstract-label">MATERIALS AND METHODS</div><div class="abstract-content">The effective compounds of JN extract were analyzed and identified using UHPLC-Q-Exactive/HRMS. Utilizing network pharmacology to investigate JN's multi-target, multi-pathway process in treating AHLS. Subsequently, anti-inflammatory activities of JN extract were evaluated in the RAW264.7 cells stimulated by lipopolysaccharide (LPS). In addition, a rat AHLS model induced by LPS and dried ginger was established. Pathological changes in rat lung and stomach tissues observed by HE staining and Masson's trichrome staining. Additionally, the expression of TNF-α, IL-6, and IL-1β in bronchoalveolar lavage fluid (BALF) was identified through the ELISA assay. For a deeper understanding of how JN might affect AHLS, transcriptomics was utilized to examine differential genes and their underlying mechanisms. Concurrently, techniques like quantitative polymerase chain reaction (q-PCR), immunofluorescence, and western blotting (WB) were employed to confirm various mRNA and protein expression, including Il17ra, Il17re, IL-17A, IL-1β, IL-6, PPARγ, PGC1-α and UCP1. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">We identified 178 potential effective components in the JN extract. Network pharmacology analysis showed that the 144 components in JN act on 200 key targets for the treatment of AHLS by suppressing inflammation, regulating energy metabolism, and gastric function. In addition, JN suppressed the LPS-stimulated generation of NO, TNF-α, IL-1β, and IL-6 in RAW264.7 cells. And JN treatment effectively alleviated lung and stomach injury and reduced inflammation in rats. Analysis of RNA-seq from lung tissues revealed JN's substantial control over crucial genes in the IL-17 signaling pathway, including Il1b and Il17ra. Likewise, RNA sequencing of stomach tissues revealed that JN markedly decreased crucial genes in the Thermogenesis pathway, including Ppargc1a and Ppara. Additional experimental findings confirmed that treatment with JN significantly reduced the expression levels of mRNA (Il17ra, Il17re, Il1b, Ppargc1a and Ucp1), and the expression levels of protein (IL-17A, IL-1β, IL-6, PPARγ, PGC1-α and UCP1). </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">This study not only analyzes the effective components of JN but also reveals that JN could effectively ameliorate AHLS by inhibiting IL-17 signaling pathway and Thermogenesis pathway, which provides evidence for subsequent clinical studies and drug development. </div> <a href="javascript:ShowArticleAbstract(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Accumulation+of+heat+in+the+lungs+and+stomach%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Accumulation of heat in the lungs and stomach</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Jingzhi+niuhuang+Jiedu+tablet%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Jingzhi niuhuang Jiedu tablet</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Network+pharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Network pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA-Sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA-Sequencing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Thermogenesis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Thermogenesis</a></li></ul> <a href="javascript:ShowArticleKeywords(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drugs%2c+Chinese+Herbal%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drugs, Chinese Herbal/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drugs%2c+Chinese+Herbal%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drugs, Chinese Herbal/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RAW+264.7+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RAW 264.7 Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lung%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lung/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lung%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lung/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lung%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lung/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Network+Pharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Network Pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Sprague-Dawley%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Sprague-Dawley</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anti-Inflammatory+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anti-Inflammatory Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipopolysaccharides%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipopolysaccharides</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transcriptome%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transcriptome/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stomach%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stomach/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stomach%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stomach/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Medicine%2c+Chinese+Traditional%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Medicine, Chinese Traditional/methods</a></li></ul> <a href="javascript:ShowArticleMeSH(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(7);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow8"> <td style="min-width: 40px; text-align: center;"> 8 </td> <td> <div id="citation8" class="article-citation"> <b>Tang S</b>, Qiu Z, Liu F, Li C, Peng G. Lipopolysaccharide aggravating anaphylactoid reactions caused by traditional Chinese Medicine injections via p38/ERK/NF-κB signaling pathways. <em>JOURNAL OF ETHNOPHARMACOLOGY</em> 2025;<b>337</b>:118946. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39419299' target='_blank'>39419299</a> DOI: <a href='https://dx.doi.org/10.1016/j.jep.2024.118946' target='_blank'>10.1016/j.jep.2024.118946</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.jep.2024.118946','39419299', 'Inflammation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(8);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(8);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(8);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.jep.2024.118946' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/19/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/19/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv8" value="10.1016/j.jep.2024.118946" /> <div style="display: none" id="articleAbstract8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">ETHNOPHARMACOLOGICAL RELEVANCE</div><div class="abstract-content">Currently, adverse reactions limit the development of traditional Chinese medicine injections (TCMI), and severe anaphylactoid shock is one of the serious adverse reactions, which presents a significant challenge. The presence of abnormal inflammatory mediators before the administration of TCMI will most likely result in severe anaphylactoid reactions. Not only that, the lack of clinically relevant safety evaluations impedes the widespread use of TCMI, and there is an urgent need for studies to reveal the mechanisms of anaphylactoid shock caused by TCMI. </div><div class="abstract-label">AIM OF THE STUDY</div><div class="abstract-content">To investigate the effects and underlying mechanisms of lipopolysaccharide (LPS)-induced inflammation, which aggravates anaphylactoid reactions caused by TCMI, utilizing a guinea pig model. </div><div class="abstract-label">METHODS</div><div class="abstract-content">The dose and duration of LPS administration and different doses of compound 48/80 (C48/80) were examined by using guinea pigs as a model. Shuanghuanglian (SHLI) and Qingkailing (QKLI) injections, these two representative TCMI, were used for validation. The plasma biochemical indices, including histamine, 5-hydroxytryptamine, tumor necrosis factor-α, interleukin 6, immunoglobulin E, C5a, tryptase, and platelet activating factor, as well as the pathological characteristics of the lung, were analyzed. Futhermore, plasma metabolomics was employed to reveal changes in metabolic pathways in vivo when inflammation co-exists with TCMI. In addition, Western blot analysis was conducted to assess the expression of critical signaling pathways. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Stimulation with 2 mg/kg of LPS for 12 h induced inflammatory responses in the guinea pig model. C48/80 (3.0 mg/kg) in combination with LPS resulted in an increase in anaphylactoid-related indicators in the plasma. High doses of SHLI and QKLI aggravated plasma indices and lung histological injury caused by LPS-induced inflammation. A total of 36 and 63 differential metabolites were significantly altered after LPS stimulation in the SHLI-and QKLI-treated guinea pig groups, respectively. The associated metabolic pathways include central carbon metabolism in cancer, the tricarboxylic acid cycle, glyoxylate and dicarboxylate metabolism. The p38/ERK/NF-κB signal pathway may be significantly affected by TCMI in vivo after LPS stimulation. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">LPS-induced inflammation aggravated anaphylactoid reactions caused by SHLI and QKLI, with a correlation to dosage. After the presence of LPS, the administration of TCMI interferes with the immune response by over-activating the p38/ERK/NF-κB signaling pathway. This activation leads to an excessive release of inflammatory factors and anaphylactoid mediators. These results present a new direction for mitigating adverse clinical reactions associated with TCMI. </div> <a href="javascript:ShowArticleAbstract(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anaphylactoid+reaction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anaphylactoid reaction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolomics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolomics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Traditional+Chinese+medicine+injections%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Traditional Chinese medicine injections</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22p38%2fERK%2fNF-%ce%baB+signaling+pathways%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">p38/ERK/NF-κB signaling pathways</a></li></ul> <a href="javascript:ShowArticleKeywords(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Guinea+Pigs%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Guinea Pigs</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipopolysaccharides%2ftoxicity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipopolysaccharides/toxicity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anaphylaxis%2fchemically+induced%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anaphylaxis/chemically induced</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drugs%2c+Chinese+Herbal%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drugs, Chinese Herbal/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drugs%2c+Chinese+Herbal%2ftoxicity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drugs, Chinese Herbal/toxicity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF-kappa+B%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF-kappa B/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22p38+Mitogen-Activated+Protein+Kinases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">p38 Mitogen-Activated Protein Kinases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Medicine%2c+Chinese+Traditional%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Medicine, Chinese Traditional</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MAP+Kinase+Signaling+System%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MAP Kinase Signaling System/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li></ul> <a href="javascript:ShowArticleMeSH(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(8);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow9"> <td style="min-width: 40px; text-align: center;"> 9 </td> <td> <div id="citation9" class="article-citation"> <b>Liu ZC</b>, Fu HJ, Li NC, Deng FJ, Gan YK, Ye YJ, Huang BH, Liu C, Chen JH, Li XF. Systematic pharmacology and experimental validation to elucidate the <span class="highlight-field">inflammation</span>-associated mechanism of Huanglian Wendan (HLWD) decoction in the treatment of MAFLD associated with atherosclerosis. <em>JOURNAL OF ETHNOPHARMACOLOGY</em> 2025;<b>337</b>:118841. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39299361' target='_blank'>39299361</a> DOI: <a href='https://dx.doi.org/10.1016/j.jep.2024.118841' target='_blank'>10.1016/j.jep.2024.118841</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.jep.2024.118841','39299361', 'Inflammation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(9);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(9);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(9);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.jep.2024.118841' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/22/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv9" value="10.1016/j.jep.2024.118841" /> <div style="display: none" id="articleAbstract9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">ETHNOPHARMACOLOGICAL RELEVANCE</div><div class="abstract-content">Metabolic-associated fatty liver disease (MAFLD) and atherosclerosis are very common disorders that frequently coexist. The therapeutic efficacy of Huanglian Wendan (HLWD) decoction, a traditional Chinese medicine (TCM) prescription, is satisfactory in treating MAFLD associated with atherosclerosis. However, the underlying mechanisms through which HLWD exerts its effects need to be elucidated. Given the complex composition of HLWD and its multiple therapeutic targets, pharmacological investigation is challenging. </div><div class="abstract-label">AIM OF THIS STUDY</div><div class="abstract-content">This study aimed to identify the effective compounds in HLWD and elucidate the mechanisms involved in its therapeutic effect on MAFLD associated with atherosclerosis. </div><div class="abstract-label">MATERIALS AND METHODS</div><div class="abstract-content">We used a systematic pharmacology method to identify effective compounds present in HLWD and determine the mechanism by which it affects MAFLD associated with atherosclerosis. The effective components of HLWD were identified through ultrahigh-performance liquid chromatography-q exactive-orbitrap high resolution mass spectrometry (UHPLC-Q-Orbitrap HRMS). Next, a comprehensive in silico method was used to predict potential related targets and disease targets for these compounds to establish corresponding pathways. The accuracy of our assumed systemic pharmacology results was determined by conducting follow-up experiments. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">By conducting UHPLC-Q-Orbitrap HRMS combined with network analysis, we identified 18 potentially active components of HLWD and assessed the inflammatory regulatory mechanism by which it affects MAFLD associated with atherosclerosis on the basis of 52 key targets. We used a high-fat, high-cholesterol (HFHC)-induced mice model of MAFLD associated with atherosclerosis to confirm our results. We found that administering HLWD significantly improved the appearance of their liver and reduced their body weight, liver weight, blood lipids, hepatic damage, and hepatic pathology. HLWD also decreased atherosclerotic lesion areas, foam cells, and inflammatory cells in the aorta. HLWD showed anti-inflammatory effects, suppressed M1 polarization, and promoted M2 polarization in the liver and aorta. HLWD might also regulate peroxisome proliferator-activated receptor-γ (PPARγ)/nuclear factor kappa-B (NF-κB) signaling to influence macrophage polarization and inflammation. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">Our results showed that HLWD protected against HFHC diet-induced MAFLD associated with atherosclerosis by regulating PPARγ/NF-κB signaling, thus adjusting macrophage polarization and inflammation. Additionally, pharmacochemistry research, network pharmacology analysis, and experimental verification can be combined to form a comprehensive model used in studies on TCM. </div> <a href="javascript:ShowArticleAbstract(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Atherosclerosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Atherosclerosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Huanglian+wendan%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Huanglian wendan</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophage+polarization%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophage polarization</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolic-associated+fatty+liver+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolic-associated fatty liver disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Network+pharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Network pharmacology</a></li></ul> <a href="javascript:ShowArticleKeywords(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Atherosclerosis%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Atherosclerosis/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drugs%2c+Chinese+Herbal%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drugs, Chinese Herbal/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drugs%2c+Chinese+Herbal%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drugs, Chinese Herbal/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drugs%2c+Chinese+Herbal%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drugs, Chinese Herbal/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatty+Liver%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatty Liver/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diet%2c+High-Fat%2fadverse+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diet, High-Fat/adverse effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anti-Inflammatory+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anti-Inflammatory Agents/pharmacology</a></li></ul> <a href="javascript:ShowArticleMeSH(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(9);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow10"> <td style="min-width: 40px; text-align: center;"> 10 </td> <td> <div id="citation10" class="article-citation"> <b>Yu Y</b>, Mao N, Yu L, Lin F, Shi X, Lu X, Yang Y, Lu Y, Wang D. YiMu-QingGong san alleviates lipopolysaccharide-induced endometritis in mice via inhibiting <span class="highlight-field">inflammation</span> and oxidative stress through regulating macrophage polarization. <em>JOURNAL OF ETHNOPHARMACOLOGY</em> 2025;<b>337</b>:118992. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39454706' target='_blank'>39454706</a> DOI: <a href='https://dx.doi.org/10.1016/j.jep.2024.118992' target='_blank'>10.1016/j.jep.2024.118992</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.jep.2024.118992','39454706', 'Inflammation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(10);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(10);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(10);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.jep.2024.118992' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/28/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv10" value="10.1016/j.jep.2024.118992" /> <div style="display: none" id="articleAbstract10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">ETHNOPHARMACOLOGICAL RELEVANCE</div><div class="abstract-content">Endometritis is a common reproductive disease in dairy cattle after calving, characterized by persistent inflammation of the endometrium. YiMu-QingGong San (YMQGS), a patented Chinese medicine formulation, has demonstrated efficacy in the treatment of clinical endometritis in dairy cattle. However, the potential mechanisms by which YMQGS alleviates endometritis remain unclear. </div><div class="abstract-label">AIM OF THE STUDY</div><div class="abstract-content">The objective of this study is to elucidate the underlying therapeutic mechanisms of YMQGS in the context of endometritis. </div><div class="abstract-label">MATERIALS AND METHODS</div><div class="abstract-content">The chemical components of YMQGS were analyzed using UHPLC/MS. The anti-inflammatory capabilities of YMQGS were assessed by inducing an inflammatory response in RAW264.7 cells with lipopolysaccharide (LPS). Moreover, a clinical model of endometritis was simulated via vaginal injection of LPS into the uterine horns to investigate the therapeutic mechanisms of YMQGS. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">YMQGS could downregulate the expression of inflammatory mediators (TNF-α, IL-6, IL-1β) by suppressing the activation of the TLRs/MyD88/TRAF6/NF-κB signaling pathway in RAW264.7 cells. Additionally, YMQGS facilitated the polarization of RAW264.7 cells towards M2-like macrophages (Mφs) while inhibiting M1-like Mφs polarization, thereby exerting anti-inflammatory effects. Further investigation revealed that YMQGS could diminish ROS production, augment cellular antioxidant capacity, preserve mitochondrial membrane potential, and reduce intracellular [Ca2+]i accumulation, thereby minimizing cellular damage. In the mouse model of endometritis, YMQGS similarly inhibited the activation of the NF-κB signaling pathway in uterine tissues and modulated Mφ polarization in the endometrium, leading to a decrease in the expression of inflammatory factors and subsidence of the inflammatory response in the endometrium. Histological staining results showed that YMQGS reduced endometrial fibrosis, increased the expression of endometrial ZO-1, Occludin and glycoprotein, protect the endometrial barrier function, and prevent the further development of endometritis. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">Collectively, the present study confirms that YMQGS possesses notable anti-inflammatory and antioxidant properties. The suppression of the NF-κB signaling pathway and the modulation of Mφ polarization emerge as the pivotal mechanisms by which YMQGS alleviates endometritis. </div> <a href="javascript:ShowArticleAbstract(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endometritis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endometritis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fibrosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fibrosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophage+polarization%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophage polarization</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF-%ce%baB%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF-κB</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Uterine+barrier%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Uterine barrier</a></li></ul> <a href="javascript:ShowArticleKeywords(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endometritis%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endometritis/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endometritis%2fchemically+induced%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endometritis/chemically induced</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipopolysaccharides%2ftoxicity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipopolysaccharides/toxicity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RAW+264.7+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RAW 264.7 Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+Stress%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative Stress/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drugs%2c+Chinese+Herbal%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drugs, Chinese Herbal/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anti-Inflammatory+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anti-Inflammatory Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anti-Inflammatory+Agents%2fisolation+%26amp%3b+purification%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anti-Inflammatory Agents/isolation & purification</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cytokines%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cytokines/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li></ul> <a href="javascript:ShowArticleMeSH(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(10);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow11"> <td style="min-width: 40px; text-align: center;"> 11 </td> <td> <div id="citation11" class="article-citation"> <b>Zhuang GD</b>, Deng SM, Chen MD, Deng CF, Gu WT, Wang SM, Tang D. Huang-Lian-Jie-Du Decoction alleviates diabetic encephalopathy by regulating <span class="highlight-field">inflammation</span> and pyroptosis via suppression of AGEs/RAGE/NF-κB pathways. <em>JOURNAL OF ETHNOPHARMACOLOGY</em> 2025;<b>337</b>:118787. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39244173' target='_blank'>39244173</a> DOI: <a href='https://dx.doi.org/10.1016/j.jep.2024.118787' target='_blank'>10.1016/j.jep.2024.118787</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.jep.2024.118787','39244173', 'Inflammation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(11);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(11);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(11);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.jep.2024.118787' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/11/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/09/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv11" value="10.1016/j.jep.2024.118787" /> <div style="display: none" id="articleAbstract11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">ETHNOPHARMACOLOGICAL RELEVANCE</div><div class="abstract-content">Cognitive dysfunction associated with diabetes, known as diabetic encephalopathy (DE), is a grave neurodegenerative condition triggered by diabetes, and persistent inflammation plays a vital role in its development. The renowned traditional Chinese medicine Huang-Lian-Jie-Du Decoction (HLJDD) is clinically proven to manage diabetes mellitus and Alzheimer's disease and is famous for its heat-clearing and detoxifying effects. However, the underlying mechanisms through which HLJDD affects DE remain to be elucidated. </div><div class="abstract-label">AIM OF THE STUDY</div><div class="abstract-content">To explore the beneficial effects of HLJDD on improving cognitive dysfunction in DE mice. </div><div class="abstract-label">STUDY DESIGN AND METHODS</div><div class="abstract-content">A diabetic mouse was established through a high-fat diet and subsequent administration of streptozotocin over five consecutive days. After the animals were confirmed to have diabetes, they were treated with HLJDD. After oral administration of HLJDD or metformin for 14 weeks, behavioral tests were used to assess their cognitive capacity. Biochemical analyses were then performed to detect levels of glucose metabolism, followed by histological analyses to assess pathological damage. Furthermore, AGEs/RAGE/NF-κB axis related proteins were detected by Western blot or immunofluorescence techniques. An advanced UPLC-Q-Orbitrap HRMS/MS analytical technique utilizing a chemical derivatization strategy was employed for comprehensive metabolic profiling of carbonyl compounds in the plasma of DE mice. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Pharmacological assessment revealed that HLJDD effectively mitigated cognitive dysfunction, normalized glucose metabolic imbalances, and repaired neuronal damage in DE mice. It reduced neuroinflammation by attenuating carbonyl stress, deactivating astrocytes and microglia, and preserving dopaminergic neurons. Additionally, metabolomics analysis revealed 18 carbonyl compounds with marked disparities between DE and control mice, with 12 metabolites approaching normal levels post-HLJDD intervention. Further investigations showed that HLJDD regulated inflammation and pyroptosis through suppressing AGEs/RAGE/NF-κB pathways. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">Our study indicated that HLJDD could ameliorate carbonyl stress via the regulation of carbonyl compound metabolism profiling, and inhibiting the AGEs/RAGE/NF-κB pathway, thereby alleviating inflammation and pyroptosis to exert beneficial effects on DE. </div> <a href="javascript:ShowArticleAbstract(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22AGEs%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">AGEs</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetic+encephalopathy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetic encephalopathy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Huang-Lian-Jie-Du+Decoction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Huang-Lian-Jie-Du Decoction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF-%ce%baB%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF-κB</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pyroptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pyroptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RAGE%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RAGE</a></li></ul> <a href="javascript:ShowArticleKeywords(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drugs%2c+Chinese+Herbal%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drugs, Chinese Herbal/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drugs%2c+Chinese+Herbal%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drugs, Chinese Herbal/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pyroptosis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pyroptosis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF-kappa+B%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF-kappa B/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Mellitus%2c+Experimental%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Mellitus, Experimental/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glycation+End+Products%2c+Advanced%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glycation End Products, Advanced/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor+for+Advanced+Glycation+End+Products%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor for Advanced Glycation End Products/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cognitive+Dysfunction%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cognitive Dysfunction/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Streptozocin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Streptozocin</a></li></ul> <a href="javascript:ShowArticleMeSH(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(11);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow12"> <td style="min-width: 40px; text-align: center;"> 12 </td> <td> <div id="citation12" class="article-citation"> <b>Shi K</b>, Jing B, Feng Y, Yu Y. Anemarrhena asphodeloides Bunge total saponins lower lipid via modulating MAOA activity to enhance defense mechanisms in mice and C. elegans. <em>JOURNAL OF ETHNOPHARMACOLOGY</em> 2025;<b>337</b>:118814. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39277062' target='_blank'>39277062</a> DOI: <a href='https://dx.doi.org/10.1016/j.jep.2024.118814' target='_blank'>10.1016/j.jep.2024.118814</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.jep.2024.118814','39277062', 'Inflammation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(12);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(12);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(12);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.jep.2024.118814' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/17/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv12" value="10.1016/j.jep.2024.118814" /> <div style="display: none" id="articleAbstract12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">ETHNOPHARMACOLOGICAL RELEVANCE</div><div class="abstract-content">Within Anemarrhena asphodeloides Bunge (AAB), the pivotal bioactive constituents are identified as Anemarrhena asphodeloides Bunge total saponins (ABS). In traditional pharmacology, ABS has exhibited notable anti-inflammatory, hypoglycemic, and cardioprotective properties. Despite these observed effects, the specific protective mechanisms of ABS against metabolic diseases and improving the endocrine system remain largely uncharted. </div><div class="abstract-label">AIM TO STUDY</div><div class="abstract-content">This work intends to shed light on the effects and intrinsic mechanisms of ABS on metabolic diseases. </div><div class="abstract-label">MATERIALS AND METHODS</div><div class="abstract-content">The characterization of ABS components was achieved through High-Performance Liquid Chromatography/Mass Spectrometry (HPLC/MS). To evaluate ABS's anti-inflammatory efficacy, mouse macrophages underwent analysis using the Griess method. Induced differentiation of mouse fibroblasts was assessed through Oil Red O staining. In an obesity model with C57BL/6 N mice, ABS administration prompted measurements of glucose and insulin tolerance. Western blot analysis quantified lipolysis and anti-inflammatory protein expression. Nile red staining gauged body fat content in C. elegans post-ABS treatment. The mechanism of ABS action was elucidated through mRNA sequencing, further validated using RNA interference technology, and nematode mutants. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">ABS showcased the ability to diminish Nitric Oxide (NO) production in inflammatory macrophages and shrink adipocyte lipid droplets. In mice experiments, ABS was effective in alleviating fat accumulation and affecting serum lipid metabolism in diabetic mice. It enhanced oral glucose tolerance and insulin tolerance while increasing lipolysis-associated protein expression. ABS notably reduced fat content in C. elegans. Mechanistically, ABS downregulated NOD-like receptor thermal protein domain associated protein 3 (NLRP3) and monoamine oxidase A (MAOA) expression while enhancing UGT, ilys-2, and ilys-3. Lipolysis emerged as a pivotal pathway for ABS in the therapeutic intervention of metabolic diseases. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">Our investigation has revealed that ABS exert a role in combating metabolic diseases by enhancing the body's defense mechanisms. ABS activate the NLRP3-neurotransmitter-visceral adipose pathway in mice, thereby bolstering resistance and diminishing fat accumulation. In C. elegans, ABS downregulated the expression of MAOA, bolstered resistance, and augmented glucuronidase activity, consequently leading to a reduction in fat content. </div> <a href="javascript:ShowArticleAbstract(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nematodes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nematodes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Obesity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Obesity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Saponins%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Saponins</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Traditional+Chinese+medicine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Traditional Chinese medicine</a></li></ul> <a href="javascript:ShowArticleKeywords(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh12" class="article-abstract"> <b style="display: block; 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padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(12);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow13"> <td style="min-width: 40px; text-align: center;"> 13 </td> <td> <div id="citation13" class="article-citation"> <b>Ferreira JCC</b>, Pereira AMN, Aranha ESP, Moraes CC, de Souza Ferreira B, Sartoratto A, Goes GR, Moraes TMP, Moraes WP. Cyperus articulatus: Anti-inflammatory and antinociceptive activity of a medicinal plant from the Amazon. <em>JOURNAL OF ETHNOPHARMACOLOGY</em> 2025;<b>337</b>:118947. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39419300' target='_blank'>39419300</a> DOI: <a href='https://dx.doi.org/10.1016/j.jep.2024.118947' target='_blank'>10.1016/j.jep.2024.118947</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.jep.2024.118947','39419300', 'Inflammation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(13);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(13);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(13);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.jep.2024.118947' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/19/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv13" value="10.1016/j.jep.2024.118947" /> <div style="display: none" id="articleAbstract13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">ETHNOPHARMACOLOGICAL RELEVANCE</div><div class="abstract-content">Cyperus articulatus L., popularly known as priprioca, is a plant used in the Amazon for perfumed baths and homemade perfumes. In traditional medicine, its rhizomes are used to treat diseases related to inflammatory processes. </div><div class="abstract-label">AIM OF THE STUDY</div><div class="abstract-content">Due to its promising bioactive properties, this study sought to investigate its phytochemistry and the anti-inflammatory and antinociceptive activity of the essential oil obtained from C. articulatus (CAEO) in in vitro and in vivo tests. </div><div class="abstract-label">MATERIAL AND METHODS</div><div class="abstract-content">The essential oil was obtained from the rhizomes of C. articulatus and extraction was carried out via hydrodistillation. Then, the oil was analyzed by GC-MS analyses. Initially, culture of RAW 264.7 macrophages stimulated by lipopolysaccharide (LPS) was used to evaluate cytotoxicity and interference in the production of mediators of the inflammatory process (nitrite, IL-1β, TNF-α and PGE2) after exposure to CAEO. The acute toxicity of CAEO was evaluated and the results were used to define doses of 10, 100 and 400 mg kg-1 for evaluation of CAEO in in vivo tests using mice. The carrageenan-induced air pouch models and the Evans test were used to evaluate the anti-inflammatory activity by measuring the number of total leukocytes and vascular permeability. Antinociceptive activity was evaluated via tests of contortions induced by acetic acid, hot plate, and formalin. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Treatment with CAEO reduced the levels of nitrite IL-1β, TNF-α and PGE2 in the macrophage culture, revealing its anti-inflammatory potential. CAEO decreased carrageenan-induced leukocyte migration and vascular permeability, which are important events related to the acute inflammatory response. Nociceptive activity was significantly inhibited by CAEO in the acetic acid-induced contortions model, hot plate, and in both phases of the formalin test. The treatment with naloxane reversed the antinociceptive effect observed in the formalin test, suggesting the participation of opioid receptors in the mechanism of action of CAEO. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">The observed results reveal the anti-inflammatory and antinocipeptive activity of C. articulatus essential oil in vivo and support the traditional use of this plant in the treatment of different diseases involving inflammation and pain. </div> <a href="javascript:ShowArticleAbstract(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Essential+oil%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Essential oil</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipopolysaccharides%2ftoxicity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipopolysaccharides/toxicity</a></li></ul> <a href="javascript:ShowArticleMeSH(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(13);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow14"> <td style="min-width: 40px; text-align: center;"> 14 </td> <td> <div id="citation14" class="article-citation"> <b>Su FZ</b>, Zhu EL, Bai CX, Zhang WS, Liu M, Li B, Jia CC, Zhang P, Zhang BW, Zou R, Li QX, Yang BY, Kuang HX, Wang QH. A comparative study on the antipyretic effect and underlying mechanisms of different bile-fermented Arisaemas. <em>JOURNAL OF ETHNOPHARMACOLOGY</em> 2025;<b>337</b>:118951. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39423945' target='_blank'>39423945</a> DOI: <a href='https://dx.doi.org/10.1016/j.jep.2024.118951' target='_blank'>10.1016/j.jep.2024.118951</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.jep.2024.118951','39423945', 'Inflammation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(14);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(14);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(14);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.jep.2024.118951' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/13/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/11/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/21/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv14" value="10.1016/j.jep.2024.118951" /> <div style="display: none" id="articleAbstract14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">ETHNOPHARMACOLOGICAL RELEVANCE</div><div class="abstract-content">Cattle bile Arisaema (CBA) and Pig bile Arisaema (PBA) are both processed products fermented from Arisaema erubescens (Wall.) Schott and animal bile, which are recorded in China Pharmacopoeia. Traditionally, bile Arisaema was often used for clearing heat and eliminating phlegm, calming wind and calming panic. Modern pharmacological researches suggest that both two drugs exert an antipyretic effect, while there is lack of the systematical and comparative evidence on underlying mechanism. </div><div class="abstract-label">AIM OF THE STUDY</div><div class="abstract-content">To comprehensively clarify the differences and underlying mechanisms of antipyretic effect of the two drugs. </div><div class="abstract-label">METHODS</div><div class="abstract-content">In this study, an accurate and reliable detection method based on ultra-performance liquid chromatography coupled with triple quadrupole mass spectrometry (UPLC-TQ MS) for comparing the content difference of bile acids from the two drugs was successfully established and applied. Besides, a dry yeast-induced fever rat model was established, and rectal temperature and content of pyrogenic cytokines were conducted to evaluate the antipyretic effect of CBA and PBA. Serum and hypothalamus untargeted metabolomics analysis based on ultra-performance liquid chromatography coupled with quadrupole-time of flight-mass spectrometry (UPLC-Q-TOF-MS/MS) technology were performed for elucidating the changes of metabolic profile. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">The results indicated that CBA and PBA both exerted a significantly antipyretic effect, but CBA showed the characteristic of quicker onset and longer duration than that of PBA. The ELISA and western blotting analysis exhibited that the underlying antipyretic mechanism of the two drugs was closely associated with inhibiting inflammation through regulating TLR4/NF-κB signaling pathway. Moreover, the metabolism pathway analysis revealed that lipid metabolism and amino acid metabolism were greatly disturbed, which showed a certain correlation with antipyretic effect of two drugs. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">Collectively, our results delineate a potential mechanism of two different bile Arisaemas against febrile via regulating metabolic disorders and targeting inhibition of inflammation for the improvement of fever symptom of the body. Notably, our current study suggested that CBA might be a better choice for suppressing fever clinically. </div> <a href="javascript:ShowArticleAbstract(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antipyretic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antipyretic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bile+Arisaema%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bile Arisaema</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hypothalamus%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hypothalamus</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolomics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolomics</a></li></ul> <a href="javascript:ShowArticleKeywords(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antipyretics%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antipyretics/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Sprague-Dawley%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Sprague-Dawley</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bile%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bile/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fever%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fever/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fermentation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fermentation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cattle%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cattle</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Swine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Swine</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chromatography%2c+High+Pressure+Liquid%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chromatography, High Pressure Liquid</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tandem+Mass+Spectrometry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tandem Mass Spectrometry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bile+Acids+and+Salts%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bile Acids and Salts/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cytokines%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cytokines/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(14);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow15"> <td style="min-width: 40px; text-align: center;"> 15 </td> <td> <div id="citation15" class="article-citation"> <b>Xie Z</b>, Liu W, Dang R, Hu X, Cai F, Xiang Z, Zhao X, Cheng X, Wang C. Effects and mechanisms of harmine on ameliorating ethanol-induced memory impairment. <em>JOURNAL OF ETHNOPHARMACOLOGY</em> 2025;<b>337</b>:118789. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39241971' target='_blank'>39241971</a> DOI: <a href='https://dx.doi.org/10.1016/j.jep.2024.118789' target='_blank'>10.1016/j.jep.2024.118789</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.jep.2024.118789','39241971', 'Inflammation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(15);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(15);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(15);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.jep.2024.118789' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/15/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/09/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv15" value="10.1016/j.jep.2024.118789" /> <div style="display: none" id="articleAbstract15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">ETHNOPHARMACOLOGICAL RELEVANCE</div><div class="abstract-content">Peganum harmala L., a traditional Uyghur ethnic medicine widely used in China, is commonly used in the treatment of conditions such as hemiplegia, forgetfulness, cough, and asthma. Harmine and other β-carboline alkaloids, one of the main active ingredients in P. harmala, have exhibited various pharmacological activities, including anti-Alzheimer's, antidepressant, anti-inflammatory, and antioxidant effects. However, the effects and underlying mechanisms of harmine on improving ethanol-induced memory impairment remain unclear. </div><div class="abstract-label">AIM OF THE STUDY</div><div class="abstract-content">This study aimed to investigate the effects of harmine on ameliorating ethanol-induced memory impairment, and to explore potential mechanisms. </div><div class="abstract-label">MATERIALS AND METHODS</div><div class="abstract-content">Ethanol (30%, i. g.) was used to induce memory impairment model. The effect of harmine on memory impairment was evaluated by Morris water maze (MWM). The histopathological analysis, immunofluorescence staining, RT-qPCR and UHPLC-MS/MS methods were performed to further investigate the underlying mechanisms. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">MWM experiments showed that harmine significantly improved ethanol-induced spatial learning memory deficit. Harmine exhibited anti-inflammatory effect by downregulating inflammatory factors such as IL-6, IL-1β and tumor necrosis factor-α (TNF-α) induced by ethanol. Harmine also upregulated brain-derived neurotrophic factor (BDNF) levels to exert neuroprotective effect. Moreover, harmine protected neuronal cells and increased the protein expression of myelin basic protein (MBP). The cellular results indicated that harmine protected SH-SY5Y cells from ethanol-induced cytotoxicity and upregulated the relative mRNA expression of synaptosome associated protein 25 (SNAP25), syntaxin 1 A (STX1A), vesicle associated membrane protein 2 (VAMP2), synaptotagmin 1 (SYT1) and synaptophysin (SYP). </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">Harmine improved ethanol-induced memory impairment by ameliorating inflammation, increasing BDNF levels, promoting synaptic vesicle fusion, protecting myelin sheath, and modulating neurotransmitter levels. These findings provided a scientific basis for development of therapeutic drugs for alcohol-induced memory impairments and other related disorders. </div> <a href="javascript:ShowArticleAbstract(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Harmine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Harmine</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Memory+impairment%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Memory impairment</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myelin+protection%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myelin protection</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurotransmitter+levels%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurotransmitter levels</a></li></ul> <a href="javascript:ShowArticleKeywords(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Harmine%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Harmine/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ethanol%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ethanol</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Memory+Disorders%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Memory Disorders/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Memory+Disorders%2fchemically+induced%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Memory Disorders/chemically induced</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain-Derived+Neurotrophic+Factor%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain-Derived Neurotrophic Factor/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuroprotective+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuroprotective Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hippocampus%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hippocampus/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hippocampus%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hippocampus/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Peganum%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Peganum/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anti-Inflammatory+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anti-Inflammatory Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li></ul> <a href="javascript:ShowArticleMeSH(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(15);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow16"> <td style="min-width: 40px; text-align: center;"> 16 </td> <td> <div id="citation16" class="article-citation"> <b>Tchinda Defo SH</b>, Moussa D, Bouvourné P, Guédang Nyayi SD, Woumitna GC, Kodji K, Wado EK, Ngatanko Abaissou HH, Foyet HS. Unpredictable chronic mild stress induced anxio-depressive disorders and enterobacteria dysbiosis: Potential protective effects of Detariummicrocarpum. <em>JOURNAL OF ETHNOPHARMACOLOGY</em> 2025;<b>337</b>:118940. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39423942' target='_blank'>39423942</a> DOI: <a href='https://dx.doi.org/10.1016/j.jep.2024.118940' target='_blank'>10.1016/j.jep.2024.118940</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.jep.2024.118940','39423942', 'Inflammation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(16);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(16);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(16);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.jep.2024.118940' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/11/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/21/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv16" value="10.1016/j.jep.2024.118940" /> <div style="display: none" id="articleAbstract16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">ETHNOPHARMACOLOGICAL RELEVANCE</div><div class="abstract-content">Detarium microcarpum Guill. & Perr. is used traditionally in Far North Cameroun to treat stomach aches, anxiety, epilepsy, and other mental disorders. </div><div class="abstract-label">AIM OF THE STUDY</div><div class="abstract-content">Evaluate the anxiolytic and antidepressant-like effects of D. microcarpum (DM) in unpredictable chronic mild stress (UCMS) model of depression in male rats and its impact on fecal enterobacteria of stressed rats. </div><div class="abstract-label">MATERIALS AND METHODS</div><div class="abstract-content">Rats were handled daily (control) or subjected to the UCMS procedure for 42 days. Anxiety-like behaviors were assessed using the light and dark box test (LBD) and the open field test (OFT). Depressive-like behaviors were assessed using the forced swimming test (FST), the sucrose preference test (SPT), and the novelty suppressed feeding test (NSFT). Feces were then collected, followed by blood, brain, and duodenum sections after sacrifice. Monoamine levels, pro-inflammatory cytokines, oxidative stress factors, and nitrosative stress were assessed. Feces were introduced into Hectoen enteric agar for the identification of enterobacteria. An in vitro growth test was performed. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">The DM ethanolic extract has significantly increased the time spent in the light box, in the LBD, and in the center area of the OFT. Moreover, the extract has significantly reduced the preference for sucrose in the SPT, the time of immobility in the FST, and the latency period to consume the pet in the NSFT. DM extract has significantly reduced serum cortisol levels. It also significantly decreased the pro-inflammatory cytokines TNF-α and Il-1β in both brain and duodenum homogenate. DM has increased the brain's serotonin, GABA, and dopamine levels. The DM extract also decreased the MDA and nitrite levels. It also increased the SOD and CAT activities in both brain and duodenal homogenate. Histologically, the DM extract restored the cell's density in hippocampi sections and prevented gut inflammation and peroxidation characterizing leaky gut syndrome. DM extract has no effect on the growth of enterobacteria species isolated in vitro. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">The ethanolic extract of DM would have anxiolytic and antidepressant effects via the modulation of the HPA axis, brain antioxidant enzyme activities, inflammation, and nitrosative stress. Moreover, it could act by preventing leaky gut syndrome. </div> <a href="javascript:ShowArticleAbstract(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anxio-depressive+effect%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anxio-depressive effect</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Detarium+microcarpum%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Detarium microcarpum</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Enterobacteriaceae%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Enterobacteriaceae</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+stress%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative stress</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22UCMS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">UCMS</a></li></ul> <a href="javascript:ShowArticleKeywords(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Plant+Extracts%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Plant Extracts/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Plant+Extracts%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Plant Extracts/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stress%2c+Psychological%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stress, Psychological/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antidepressive+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antidepressive Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Enterobacteriaceae%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Enterobacteriaceae/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anti-Anxiety+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anti-Anxiety Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dysbiosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dysbiosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Wistar%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Wistar</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Behavior%2c+Animal%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Behavior, Animal/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Depressive+Disorder%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Depressive Disorder/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+Stress%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative Stress/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Feces%2fmicrobiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Feces/microbiology</a></li></ul> <a href="javascript:ShowArticleMeSH(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(16);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow17"> <td style="min-width: 40px; text-align: center;"> 17 </td> <td> <div id="citation17" class="article-citation"> <b>Ilavarasan R</b>, Arunadevi R, Kusuma G, Gaidhani SN, Thenmozhi M, Manikandan N. Evaluation of Anti-arthritic and in-vitro Anti-inflammatory activity of Vaisvanara Churna. <em>JOURNAL OF ETHNOPHARMACOLOGY</em> 2025;<b>337</b>:118774. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39218128' target='_blank'>39218128</a> DOI: <a href='https://dx.doi.org/10.1016/j.jep.2024.118774' target='_blank'>10.1016/j.jep.2024.118774</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.jep.2024.118774','39218128', 'Inflammation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(17);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(17);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(17);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.jep.2024.118774' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/04/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv17" value="10.1016/j.jep.2024.118774" /> <div style="display: none" id="articleAbstract17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">ETHNOPHARMACOLOGICAL RELEVANCE</div><div class="abstract-content">Vaisvanara Churna used traditionally for the treatment of Amavata (Rheumatoid arthritis), Shotaprasamana (Anti-inflammatory) and as Saraka (Laxative). </div><div class="abstract-label">AIM</div><div class="abstract-content">Aim of the study is to evaluate anti arthritic activity and in vitro anti-inflammatory potential of Vaisvanara Churna in experimental animals. </div><div class="abstract-label">MATERIALS AND METHODS</div><div class="abstract-content">In-vitro anti-inflammatory activity of aqueous extract of Vaisvanara Churna (100-500 μg/ml) was evaluated by using membrane stabilization methods. Anti arthritic activity was evaluated by using 0.1 ml of Complete Freund's Adjuvant (CFA) injected into sub plantar surface of left hind paw of each wistar rat on day 1 followed by treatment with Vaisvanara Churna at various dose levels (450, 900, and 1800 mg/kg b.w) and standard drug Prednisolone (5 mg/kg) for 21 days. The following parameters namely change in the body weight of animals, paw volume, ankle joint thickness were measured at 0, 3, 8, 17 & 21 day intervals and radiographic changes were assessed. In addition to this, response to painful stimuli by application of forced pressure was measured by using Pressure Application Measurement (PAM) method. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">In-vitro anti-inflammatory activity Vaisvanara Churna exhibited dose dependent membrane stabilizing activity. Treatment with Vaisvanara Churna showed significant (p < 0.05) inhibition of paw edema, reduction in ankle joint thickness and increase in the body weight of wistar albino rats was observed. There is a significant increase (p < 0.001) in the latency of limb withdrawal response, reduction in the organ indices (spleen and thymus) were noted. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">This study demonstrates that Vaisvanara Churna possesses in vitro anti inflammatory and anti-arthritic potential and supports its folklore use in the treatment of arthritis. </div> <a href="javascript:ShowArticleAbstract(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ayurveda%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ayurveda</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Complete+Freund%27s+adjuvant%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Complete Freund's adjuvant</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Vaisvanara+churna%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Vaisvanara churna</a></li></ul> <a href="javascript:ShowArticleKeywords(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Wistar%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Wistar</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Plant+Extracts%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Plant Extracts/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anti-Inflammatory+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anti-Inflammatory Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Experimental%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Experimental/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Experimental%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Experimental/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Freund%27s+Adjuvant%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Freund's Adjuvant</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Edema%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Edema/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antirheumatic+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antirheumatic Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ankle+Joint%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ankle Joint/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ankle+Joint%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ankle Joint/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phytotherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phytotherapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dose-Response+Relationship%2c+Drug%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dose-Response Relationship, Drug</a></li></ul> <a href="javascript:ShowArticleMeSH(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(17);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow18"> <td style="min-width: 40px; text-align: center;"> 18 </td> <td> <div id="citation18" class="article-citation"> <b>Zhang Z</b>, Yang W, Chen J, Chen X, Gu Y. Efficacy and mechanism of Schisandra chinensis active component Gomisin A on diabetic skin wound healing: network pharmacology and in vivo experimental validation. <em>JOURNAL OF ETHNOPHARMACOLOGY</em> 2025;<b>337</b>:118828. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39303965' target='_blank'>39303965</a> DOI: <a href='https://dx.doi.org/10.1016/j.jep.2024.118828' target='_blank'>10.1016/j.jep.2024.118828</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.jep.2024.118828','39303965', 'Inflammation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(18);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(18);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(18);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.jep.2024.118828' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/22/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv18" value="10.1016/j.jep.2024.118828" /> <div style="display: none" id="articleAbstract18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">ETHNOPHARMACOLOGICAL RELEVANCE</div><div class="abstract-content">Schisandra chinensis (Turcz.) Baill., a common traditional Chinese herbal medicine, has been used for the treatment of diabetes mellitus and its complications. However, the major active component for treating diabetic foot ulcers, a serious complication of diabetes mellitus, was unclear. This study aimed to predict the treatment effect of the active components in Schisandra chinensis against diabetic skin wound using network pharmacology and to confirm the underlying mechanism using a diabetic skin wound model in vivo. </div><div class="abstract-label">AIM OF THE STUDY</div><div class="abstract-content">To study the effects and underlying mechanisms of Schisandra chinensis and its main component Gomisin A on diabetic skin wound healing by network pharmacology and high-fat diet (HFD)-induced obese mice model in vivo. </div><div class="abstract-label">MATERIALS AND METHODS</div><div class="abstract-content">To determine the effectiveness of Schisandra chinensis on diabetic skin wound, network pharmacology was first used. Components of Schisandra chinensis were obtained from the Traditional Chinese Medicine Systems Pharmacology database. The active components were further verified through absorption, distribution, metabolism and excretion. The potential targets of the active components were identified from the Traditional Chinese Medicine Systems Pharmacology, SwissTargetPrediction, TargetNet, and the Comparative Toxicogenomics Database. Targets related to diabetic skin wound were collected from the GeneCards, OMIM, DisGeNET, and PharmGKB databases. The interaction network formed by the intersection of the two datasets was analyzed using Gephi. Network-based proximity was used to predict the network distance between the active components of Schisandra chinensis and diabetic skin wound. Gomisin A was found to have the lowest Z-score and was administered either orally or via topical injection to HFD-induced obese mice daily until the wounds healed, and its effects on skin wound healing were evaluated. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Only five active ingredients of Schisandra chinensis were screened in our system: Gomisin A, Longikaurin A, Deoxyharringtonine, Wuweizisu C, and Interiotherin B, which can regulate biological processes related to diabetic skin wound, including positive regulation of phosphorous metabolic process, positive regulation of cell migration, and response to wounding. Network proximity analysis found that Gomisin A has the closest distance-based Z-score among the diabetic skin wound modules and drug targets in the human protein-protein interaction network. The HFD-induced obese mice model further revealed that Gomisin A accelerated skin wound healing by increasing insulin sensitivity and decreasing the advanced glycation end-products mediated toll-like receptor 4 (TLR4)-p38 MAPK-IL6 inflammation signaling pathway. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">The network pharmacology and in vivo studies indicated that Gomisin A from Schisandra chinensis played a crucial role in improving diabetic skin wound healing. </div> <a href="javascript:ShowArticleAbstract(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gomisin+A%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gomisin A</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Network+pharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Network pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Schisandra+chinensis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Schisandra chinensis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Skin+wound%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Skin wound</a></li></ul> <a href="javascript:ShowArticleKeywords(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Schisandra%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Schisandra/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Wound+Healing%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Wound Healing/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Network+Pharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Network Pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cyclooctanes%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cyclooctanes/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diet%2c+High-Fat%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diet, High-Fat</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diabetes+Mellitus%2c+Experimental%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diabetes Mellitus, Experimental/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lignans%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lignans/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Skin%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Skin/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Skin%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Skin/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Skin%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Skin/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Skin%2finjuries%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Skin/injuries</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polycyclic+Compounds%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polycyclic Compounds/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drugs%2c+Chinese+Herbal%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drugs, Chinese Herbal/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drugs%2c+Chinese+Herbal%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drugs, Chinese Herbal/chemistry</a></li></ul> <a href="javascript:ShowArticleMeSH(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(18);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow19"> <td style="min-width: 40px; text-align: center;"> 19 </td> <td> <div id="citation19" class="article-citation"> <b>Szternel Ł</b>, Sobucki B, Wieprzycka L, Krintus M, Panteghini M. Golgi protein 73 in liver fibrosis. <em class='incite-journal-name' onclick='ShowInCiteJournal(6300);'>Clin Chim Acta</em> 2025;<b>565</b>:119999. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39401651' target='_blank'>39401651</a> DOI: <a href='https://dx.doi.org/10.1016/j.cca.2024.119999' target='_blank'>10.1016/j.cca.2024.119999</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.cca.2024.119999','39401651', 'Inflammation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(19);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(19);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(19);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.cca.2024.119999' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(6300);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 09/11/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/17/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv19" value="10.1016/j.cca.2024.119999" /> <div style="display: none" id="articleAbstract19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Golgi protein 73 (GP73) is implicated in key pathogenic processes, particularly those related to inflammation and fibrogenesis. In the last years, its measurement has emerged as a promising biomarker for detection of liver fibrosis (LF), a common consequence of chronic liver disease that can progress to cirrhosis and eventually hepatocellular carcinoma. GP73 concentrations in blood appear significantly increased in LF patients, correlating with disease severity, making this biomarker a possible non-invasive alternative for detecting and monitoring this condition regardless of etiology. Understanding the molecular mechanisms involving GP73 expression could also lead to new therapeutic strategies aimed at modulating its synthesis or function to prevent or reverse LF. Despite its clinical potential, GP73 as a LF biomarker faces several challenges. The lack of demonstrated comparability among different assays as well as the lack of knowledge of individual variability can make difficult the result interpretation. Further research is therefore needed focusing on robust clinical validation of GP73 as a LF biomarker. Addressing analytical, biological, and clinical limitations will be critical to exploiting its potential for improving detection and monitoring of advanced LF. </div> <a href="javascript:ShowArticleAbstract(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Golgi+protein+73%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Golgi protein 73</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+fibrosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver fibrosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolic+dysfunction-associated+steatotic+liver+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolic dysfunction-associated steatotic liver disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Non-invasive+test%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Non-invasive test</a></li></ul> <a href="javascript:ShowArticleKeywords(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Cirrhosis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Cirrhosis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Cirrhosis%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Cirrhosis/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Cirrhosis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Cirrhosis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Cirrhosis%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Cirrhosis/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Membrane+Proteins%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Membrane Proteins/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Membrane+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Membrane Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomarkers%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomarkers/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomarkers%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomarkers/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(19);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow20"> <td style="min-width: 40px; text-align: center;"> 20 </td> <td> <div id="citation20" class="article-citation"> <b>Yang Y</b>, Chen Q, Liu Z, Huang T, Hong Y, Li N, Ai K, Huang Q. Novel reduced heteropolyacid nanoparticles for effective treatment of drug-induced liver injury by manipulating reactive oxygen and nitrogen species and inflammatory signals. <em class='incite-journal-name' onclick='ShowInCiteJournal(13537);'>J Colloid Interface Sci</em> 2025;<b>678</b>:174-187. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39243718' target='_blank'>39243718</a> DOI: <a href='https://dx.doi.org/10.1016/j.jcis.2024.08.239' target='_blank'>10.1016/j.jcis.2024.08.239</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.jcis.2024.08.239','39243718', 'Inflammation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(20);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(20);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(20);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.jcis.2024.08.239' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(13537);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/09/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv20" value="10.1016/j.jcis.2024.08.239" /> <div style="display: none" id="articleAbstract20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">With the rapid advancements in biomedicine, the use of clinical drugs has surged sharply. However, potential hepatotoxicity limits drug exploitation and widespread usage, posing serious threats to patient health. Hepatotoxic drugs disrupt liver enzyme levels and cause refractory pathological damage, creating a challenge in the application of diverse first-line drugs. The activation and deterioration of reactive oxygen and nitrogen species (RONS) and inflammatory signals are key pathological mechanisms of drug-induced liver injury (DILI). Herein, a novel reduced heteropolyacid nanoparticle (RNP) has been developed, possessing high RONS-scavenging ability, strong anti-inflammatory activity, and excellent biosafety. These features enable it to swiftly restore the redox and immune balance of the liver. Intravenous administration of RNP effectively scavenged RONS storm, reversing liver oxidative stress and restoring normal mitochondrial membrane potential and function. Furthermore, by inhibiting c-Jun-N-terminal kinase phosphorylation, RNP facilitated the restoration of nuclear factor erythroid 2-related factor 2-mediated endogenous antioxidant signaling, ultimately rescuing the liver function and tissue morphology in acetaminophen-induced DILI mice. Crucially, the high biocompatible RNP exhibited superior efficacy in the DILI mouse model compared to the clinical antioxidant N-acetylcysteine. This targeted therapeutic approach, tailored to address the onset and progression of DILI, offers valuable new insights into controlling the condition and restoring liver structure and function. </div> <a href="javascript:ShowArticleAbstract(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug-induced+liver+injury%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug-induced liver injury</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mitochondria%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mitochondria</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RONS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RONS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reduced+heteropolyacid+nanoparticles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reduced heteropolyacid nanoparticles</a></li></ul> <a href="javascript:ShowArticleKeywords(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chemical+and+Drug+Induced+Liver+Injury%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chemical and Drug Induced Liver Injury/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chemical+and+Drug+Induced+Liver+Injury%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chemical and Drug Induced Liver Injury/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chemical+and+Drug+Induced+Liver+Injury%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chemical and Drug Induced Liver Injury/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reactive+Oxygen+Species%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reactive Oxygen Species/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%2fchemically+induced%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation/chemically induced</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Particle+Size%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Particle Size</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Surface+Properties%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Surface Properties</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anti-Inflammatory+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anti-Inflammatory Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anti-Inflammatory+Agents%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anti-Inflammatory Agents/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polymers%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polymers/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polymers%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polymers/pharmacology</a></li></ul> <a href="javascript:ShowArticleMeSH(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(20);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow21"> <td style="min-width: 40px; text-align: center;"> 21 </td> <td> <div id="citation21" class="article-citation"> <b>Zhang M</b>, Shang L, Zhou F, Li J, Wang S, Lin Q, Cai Y, Yang S. Dachengqi decoction dispensing granule ameliorates LPS-induced acute lung injury by inhibiting PANoptosis in vivo and in vitro. <em>JOURNAL OF ETHNOPHARMACOLOGY</em> 2025;<b>336</b>:118699. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39181290' target='_blank'>39181290</a> DOI: <a href='https://dx.doi.org/10.1016/j.jep.2024.118699' target='_blank'>10.1016/j.jep.2024.118699</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.jep.2024.118699','39181290', 'Inflammation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(21);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(21);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(21);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.jep.2024.118699' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/13/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/27/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv21" value="10.1016/j.jep.2024.118699" /> <div style="display: none" id="articleAbstract21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">ETHNOPHARMACOLOGICAL RELEVANCE</div><div class="abstract-content">Acute lung injury (ALI) is a serious health-threatening syndrome of intense inflammatory response in the lungs, with progression leading to acute respiratory distress syndrome (ARDS). Dachengqi decoction dispensing granule (DDG) has a pulmonary protective role, but its potential modulatory mechanism to alleviate ALI needs further excavation. </div><div class="abstract-label">AIM OF THE STUDY</div><div class="abstract-content">This study aims to investigate the effect and potential mechanism of DDG on lipopolysaccharide (LPS)-induced ALI models in vivo and in vitro. </div><div class="abstract-label">MATERIALS AND METHODS</div><div class="abstract-content">LPS-treated Balb/c mice and BEAS-2B cells were used to construct in vivo and in vitro ALI models, respectively. Hematoxylin-eosin (HE), Wet weight/Dry weight (W/D) calculation of lung tissue, and total protein and Lactic dehydrogenase (LDH) assays in BALF were performed to assess the extent of lung tissue injury and pulmonary edema. Enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), and interleukin-18 (IL-18) in BALF, serum, and cell supernatant. The qRT-PCR was used to detect inflammatory factors, Z-DNA binding protein 1 (ZBP1), and receptor-interacting protein kinase 1 (RIPK1) expression in lung tissues and BEAS-2B cells. Double immunofluorescence staining and co-immunoprecipitation were used to detect the relative expression and co-localization of ZBP1 and RIPK1. The effects of LPS and DDG on BEAS-2B cell activity were detected by Cell Counting Kit-8 (CCK-8). Western blot (WB) was performed to analyze the expression of PANoptosis-related proteins in lung tissues and BEAS-2B cells. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">In vivo, DDG pretreatment could dose-dependently improve the pathological changes of lung tissue in ALI mice, and reduce the W/D ratio of lung, total protein concentration, and LDH content in BALF. In vitro, DDG reversed the inhibitory effect of LPS on BEAS-2B cell viability. Meanwhile, DDG significantly reduced the levels of inflammatory factors in vitro and in vivo. In addition, DDG could inhibit the expression levels of PANoptosis-related proteins, especially the upstream key regulatory molecules ZBP1 and RIPK1. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">DDG could inhibit excessive inflammation and PANoptosis to alleviate LPS-induced ALI, thus possessing good anti-inflammatory and lung-protective effects. This study establishes a theoretical basis for the further development of DDG and provides a new prospect for ALI treatment by targeting PANoptosis. </div> <a href="javascript:ShowArticleAbstract(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Acute+lung+injury%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Acute lung injury</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dachengqi+decoction+dispensing+granule%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dachengqi decoction dispensing granule</a></li><li><a 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Herbal/therapeutic use</a></li></ul> <a href="javascript:ShowArticleMeSH(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(21);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow22"> <td style="min-width: 40px; text-align: center;"> 22 </td> <td> <div id="citation22" class="article-citation"> <b>Mahmoudi J</b>, Kazmi S, Vatandoust S, Athari SZ, Sadigh-Eteghad S, Morsali S, Bahari L, Ahmadi M, Hosseini L, Farajdokht F. Coenzyme Q10 and vitamin E alleviate heat stress-induced mood disturbances in male mice: Modulation of inflammatory pathways and the HPA axis. <em class='incite-journal-name' onclick='ShowInCiteJournal(3378);'>Behav Brain Res</em> 2025;<b>476</b>:115259. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39303989' target='_blank'>39303989</a> DOI: <a href='https://dx.doi.org/10.1016/j.bbr.2024.115259' target='_blank'>10.1016/j.bbr.2024.115259</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.bbr.2024.115259','39303989', 'Inflammation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(22);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(22);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(22);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.bbr.2024.115259' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3378);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/04/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/22/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv22" value="10.1016/j.bbr.2024.115259" /> <div style="display: none" id="articleAbstract22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Heat stress, as an environmental stressor, can lead to temperature dysregulation and neuroinflammation, causing depression and anxiety by disrupting brain physiology and functional connectivity. This study looked at how co-enzyme Q10 (Q10) and vitamin E (Vit E), alone and together, affected heat stress-caused anxiety and depression symptoms and inflammation in male mice. Five groups were utilized in the study: control, heat stress (NS), Q10, Vit E, and the combination group (Q10+Vit E). The mice were subjected for 15 min/day to a temperature of 43°C for 14 consecutive days, followed by daily treatments for two weeks with either normal saline, Q10 (500 mg/kg), Vit E (250 mg/kg), or their combination. The forced swimming test (FST) and tail suspension test (TST) were employed to evaluate despair behavior, whereas the elevated plus maze (EPM) and open field test (OFT) were used to assess anxious behaviors. Subsequently, the animals were sacrificed, and serum corticosterone levels, protein expression of inflammasome-related proteins, and hsp70 gene expression were evaluated in the prefrontal cortex (PFC). The study revealed that treatment with Vit E and Q10, alone or together, provided anxiolytic and antidepressant effects in the heat-stress-subjected animals. Also, giving Vit E and Q10 alone or together greatly lowered serum corticosterone levels. In the PFC, they also lowered the levels of hsp70 mRNA and NF-κB, caspase 1, NLRP3, and IL-1β proteins. It is speculated that treatment with Q10 and Vit E can attenuate heat stress-associated anxious and depressive responses by inhibiting the inflammatory pathways and modulating the hypothalamus-pituitary-adrenal axis. </div> <a href="javascript:ShowArticleAbstract(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anxiety%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anxiety</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Corticosterone%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Corticosterone</a></li><li><a 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Animal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22HSP70+Heat-Shock+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HSP70 Heat-Shock Proteins/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(22);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow23"> <td style="min-width: 40px; text-align: center;"> 23 </td> <td> <div id="citation23" class="article-citation"> <b>Mohan M</b>, Mannan A, Nauriyal A, Singh TG. Emerging targets in amyotrophic lateral sclerosis (ALS): The promise of ATP-binding cassette (ABC) transporter modulation. <em class='incite-journal-name' onclick='ShowInCiteJournal(3378);'>Behav Brain Res</em> 2025;<b>476</b>:115242. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39243983' target='_blank'>39243983</a> DOI: <a href='https://dx.doi.org/10.1016/j.bbr.2024.115242' target='_blank'>10.1016/j.bbr.2024.115242</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.bbr.2024.115242','39243983', 'Inflammation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(23);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(23);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(23);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.bbr.2024.115242' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3378);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/13/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/09/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv23" value="10.1016/j.bbr.2024.115242" /> <div style="display: none" id="articleAbstract23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative primarily affecting motor neurons, leading to disability and neuronal death, and ATP-Binding Cassette (ABC) transporter due to their role in drug efflux and modulation of various cellular pathways contributes to the pathogenesis of ALS. In this article, we extensively investigated various molecular and mechanistic pathways linking ALS transporter to the pathogenesis of ALS; this involves inflammatory pathways such as Mitogen-Activated Protein Kinase (MAPK), Phosphatidylinositol-3-Kinase/Protein Kinase B (PI3K/Akt), Toll-Like Receptor (TLR), Glycogen Synthase Kinase 3β (GSK-3β), Nuclear Factor Kappa-B (NF-κB), and Cyclooxygenase (COX). Oxidative pathways such as Astrocytes, Glutamate, Nuclear factor (erythroid-derived 2)-like 2 (Nrf2), Sirtuin 1 (SIRT-1), Forkhead box protein O (FOXO), Extracellular signal-regulated kinase (ERK). Additionally, we delve into the role of autophagic pathways like TAR DNA-binding protein 43 (TDP-43), AMP-activated protein kinase (AMPK), mammalian target of rapamycin (mTOR), and lastly, the apoptotic pathways. Furthermore, by understanding these intricate interactions, we aim to develop novel therapeutic strategies targeting ABC transporters, improving drug delivery, and ultimately offering a promising avenue for treating ALS. </div> <a href="javascript:ShowArticleAbstract(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ATP-binding+cassette+(ABC)+transporters%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ATP-binding cassette (ABC) transporters</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apoptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apoptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Molecular+pathways%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Molecular pathways</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Motor+neurons%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Motor neurons</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurodegeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurodegeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+stress%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative stress</a></li></ul> <a href="javascript:ShowArticleKeywords(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Amyotrophic+Lateral+Sclerosis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Amyotrophic Lateral Sclerosis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ATP-Binding+Cassette+Transporters%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ATP-Binding Cassette Transporters/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/physiology</a></li></ul> <a href="javascript:ShowArticleMeSH(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(23);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow24"> <td style="min-width: 40px; text-align: center;"> 24 </td> <td> <div id="citation24" class="article-citation"> <b>Dos Santos GG</b>, Bachi ALL, Rangel SC, da Silva Nali LH, Daca TSL, do Amaral JB, Juliano Y, Natrielli-Filho DG, Rossi FE, Gil S, Lafer B, Neves LM. Acute and chronic response of supervised band-elastic resistance exercise in systemic cytokines levels of bipolar disorders and schizophrenia individuals: A pilot study. <em class='incite-journal-name' onclick='ShowInCiteJournal(3378);'>Behav Brain Res</em> 2025;<b>476</b>:115248. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39260584' target='_blank'>39260584</a> DOI: <a href='https://dx.doi.org/10.1016/j.bbr.2024.115248' target='_blank'>10.1016/j.bbr.2024.115248</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.bbr.2024.115248','39260584', 'Inflammation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(24);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(24);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(24);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.bbr.2024.115248' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3378);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 12/02/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 04/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/13/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv24" value="10.1016/j.bbr.2024.115248" /> <div style="display: none" id="articleAbstract24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Despite earlier research demonstrating the immunomodulatory effects of acute and chronic exercise in many medical illnesses, there is a lack of literature evaluating the acute and chronic effects of exercise on the cytokine levels in individuals with bipolar disorder (BD) or schizophrenia (SCH). This study aims to examine the acute effects of resistance exercise on cytokines and the chronic effects of resistance exercise by 10 weeks on cytokine levels, symptoms of disease, and muscular strength in individuals with BD and SCH. The included individuals (N=10) performed a single session of band-elastic resistance exercises (six exercises, 3 sets of 12-15 repetitions, 60 seconds of interval between sets). A sub-sample (N=6) of individuals performed a supervised band-elastic resistance exercise program (2 times a week, for 10 weeks, 6 exercises, 3 sets of 12-15 repetitions, 60 seconds of interval). We verified for acute effects: IL-2 (P=0.0085) and IL-4 (P=0.0253) levels increased, while IL-6 decreased (P=0.0435), and for chronic effects: increased IL-2 and IL-4 levels (significant effect size - Pre vs Post), a decrease in disease symptoms, and an increase in muscular strength. This study adds to what is already known about how resistance exercises affect people with BD and SCH in both short-term (systemic cytokines levels) and long-term (symptoms of disease, muscular strength, and systemic cytokines levels). </div> <a href="javascript:ShowArticleAbstract(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mental+health%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mental health</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Physical+activity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Physical activity</a></li></ul> <a href="javascript:ShowArticleKeywords(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bipolar+Disorder%2fphysiopathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bipolar Disorder/physiopathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bipolar+Disorder%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bipolar Disorder/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Resistance+Training%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Resistance Training/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pilot+Projects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pilot Projects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Schizophrenia%2fphysiopathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Schizophrenia/physiopathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Schizophrenia%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Schizophrenia/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cytokines%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cytokines/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Muscle+Strength%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Muscle Strength/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Interleukin-6%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Interleukin-6/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Interleukin-4%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Interleukin-4/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Interleukin-2%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Interleukin-2/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Young+Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Young Adult</a></li></ul> <a href="javascript:ShowArticleMeSH(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(24);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow25"> <td style="min-width: 40px; text-align: center;"> 25 </td> <td> <div id="citation25" class="article-citation"> <b>Sethi P</b>, Mehan S, Khan Z, Maurya PK, Kumar N, Kumar A, Tiwari A, Sharma T, Das Gupta G, Narula AS, Kalfin R. The SIRT-1/Nrf2/HO-1 axis: Guardians of neuronal health in neurological disorders. <em class='incite-journal-name' onclick='ShowInCiteJournal(3378);'>Behav Brain Res</em> 2025;<b>476</b>:115280. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39368713' target='_blank'>39368713</a> DOI: <a href='https://dx.doi.org/10.1016/j.bbr.2024.115280' target='_blank'>10.1016/j.bbr.2024.115280</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.bbr.2024.115280','39368713', 'Inflammation')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(25);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(25);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(25);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.bbr.2024.115280' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3378);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/07/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv25" value="10.1016/j.bbr.2024.115280" /> <div style="display: none" id="articleAbstract25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">SIRT1 (Sirtuin 1) is a NAD+-dependent deacetylase that functions through nucleoplasmic transfer and is present in nearly all mammalian tissues. SIRT1 is believed to deacetylate its protein substrates, resulting in neuroprotective actions, including reduced oxidative stress and inflammation, increased autophagy, increased nerve growth factors, and preserved neuronal integrity in aging or neurological disease. Nrf2 is a transcription factor that regulates the genes responsible for oxidative stress response and substance detoxification. The activation of Nrf2 guards cells against oxidative damage, inflammation, and carcinogenic stimuli. Several neurological abnormalities and inflammatory disorders have been associated with variations in Nrf2 activation caused by either pharmacological or genetic factors. Recent evidence indicates that Nrf2 is at the center of a complex cellular regulatory network, establishing it as a transcription factor with genuine pleiotropy. HO-1 is most likely a component of a defense mechanism in cells under stress, as it provides negative feedback for cell activation and mediator synthesis. This mediator is upregulated by Nrf2, nitric oxide (NO), and other factors in various inflammatory states. HO-1 or its metabolites, such as CO, may mitigate inflammation by modulating signal transduction pathways. Neurological diseases may be effectively treated by modulating the activity of HO-1. Multiple studies have demonstrated that SIRT1 and Nrf2 share an important connection. SIRT1 enhances Nrf2, activates HO-1, protects against oxidative injury, and decreases neuronal death. This has been associated with numerous neurodegenerative and neuropsychiatric disorders. Therefore, activating the SIRT1/Nrf2/HO-1 pathway may help treat various neurological disorders. This review focuses on the current understanding of the SIRT1 and Nrf2/HO-1 neuroprotective processes and the potential therapeutic applications of their target activators in neurodegenerative and neuropsychiatric disorders. </div> <a href="javascript:ShowArticleAbstract(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22HO-1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HO-1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation</a></li><li><a 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class="dxpc-maximizeBtn"> <img id="RootHolder_pcEditArticleControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Edit My Journal Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content" style="overflow-x:hidden;overflow-y:scroll;">    </div> </div> </div> </div><div id="RootHolder_pcEditArticleControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcEditArticleControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcEditArticleControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcEditArticleControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_298765222" type="text/javascript">  </script> <div id="RootHolder_userIndexComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:400px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Article Influence Index</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle2">Article Influence Index</span></b> </p> <p> Total Citations in Crossref ÷ Total Articles = <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle3">Article Influence Index</span><sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="RootHolder_userIndexComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_userIndexComputePopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_userIndexComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1286575841" type="text/javascript">  </script> <div id="RootHolder_articleExportPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:280px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow" style="font-size:11pt;"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_articleExportPopup_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Export Articles to File</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="dxtcLite_MetropolisBlue dxtcSys dxtc-init dxtc-top dxtc-pc" id="RootHolder_articleExportPopup_ExportFilePageControl" style="width:100%;"> <ul class="dxtc-strip dxtc-row dxtc-stripContainer"> <li class="dxtc-leftIndent"> </li><li class="dxtc-tab dxtc-lead" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-activeTab dxtc-lead"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-spacer"> </li><li class="dxtc-tab dxtc-last"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-activeTab dxtc-last" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-rightIndent"> </li> </ul><div class="dxtc-content"> <div> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_SearchTermText1">Inflammation (39249 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:5px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_1662381219" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailEndIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" value="600" type="text" /></td> </tr> </table><script id="dxss_616434442" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_1167331127" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_54524200" type="text/javascript">  </script><script id="dxss_1678130197" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" style="font-weight:bold;">JCR Year:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" type="hidden" value="2023" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" value="2023" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2023</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2022</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2021</td> </tr> </table> </div></td> </tr> </table><script id="dxss_830317689" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_167955898" type="text/javascript">  </script><script id="dxss_2013408041" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1062639383" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_104403608" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1973673553" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_6" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLTSys dxflItemSys dxflCheckBoxWithTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" style="font-weight:bold;">Record Content:</label></td> </tr><tr> <td class="dxflNestedControlCell_MetropolisBlue"> <table> <tr> <td style="vertical-align: middle; padding: 5px;"> <table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields" style="color:#BD4100;"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$cbSelectAllFields" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label>Select All Fields</label></td> </tr> </table><script id="dxss_1176833720" type="text/javascript">  </script> </td> </tr> <tr> <td style="padding: 5px;"> <table class="dxeCheckBoxList_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields" style="width:100%;border-collapse:separate;"> <tr> <td class="dxe"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields" /><table style="width:100%;"> <tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB0" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Author(s)</label></td> </tr> </table><script id="dxss_771536870" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB1" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Title</label></td> </tr> </table><script id="dxss_1086331335" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB2" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Keywords</label></td> </tr> </table><script id="dxss_1308541020" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB3" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">MESH Headings</label></td> </tr> </table><script id="dxss_896786043" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB4" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Journal Title</label></td> </tr> </table><script id="dxss_450242410" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB5" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Year</label></td> </tr> </table><script id="dxss_765036875" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB6" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Type</label></td> </tr> </table><script id="dxss_1629835480" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB7" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Language</label></td> </tr> </table><script id="dxss_1218080503" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB8" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Published Date</label></td> </tr> </table><script id="dxss_1428514578" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB9" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author</label></td> </tr> </table><script id="dxss_1113720113" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB10" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author’s Affiliations</label></td> </tr> </table><script id="dxss_310841941" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB11" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author</label></td> </tr> </table><script id="dxss_1301541094" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB12" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author’s Affiliations</label></td> </tr> </table><script id="dxss_675718561" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB13" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Email</label></td> </tr> </table><script id="dxss_2006865700" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB14" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">All Authors's Affiliations</label></td> </tr> </table><script id="dxss_1204905793" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB15" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Grant</label></td> </tr> </table><script id="dxss_407477242" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB16" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">ISSN</label></td> </tr> </table><script id="dxss_218345291" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB17" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Publisher</label></td> </tr> </table><script id="dxss_1394037744" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB18" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexing / Abstracting</label></td> </tr> </table><script id="dxss_319681069" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB19" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Factor</label></td> </tr> </table><script id="dxss_1292701966" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB20" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">JCR Quartile</label></td> </tr> </table><script id="dxss_1844280938" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB21" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Index Per Article</label></td> </tr> </table><script id="dxss_838303323" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB22" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Category</label></td> </tr> </table><script id="dxss_1464125856" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB23" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Times Cited in RCA</label></td> </tr> </table><script id="dxss_148257179" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB24" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Peer-Reviewed Journal</label></td> </tr> </table><script id="dxss_950217086" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB25" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Open Access</label></td> </tr> </table><script id="dxss_1732367175" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB26" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">DOI</label></td> </tr> </table><script id="dxss_1936777588" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB27" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">PMID</label></td> </tr> </table><script id="dxss_745806673" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB28" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Citation</label></td> </tr> </table><script id="dxss_1835441810" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB29" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexed in RCA</label></td> </tr> </table><script id="dxss_847142451" type="text/javascript">  </script></td><td></td><td></td> </tr> </table></td> </tr> </table><script id="dxss_1169734383" type="text/javascript">  </script> </td> </tr> </table> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_7" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportedDetailFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_1198171345" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_1960175520" type="text/javascript">  </script> </div> </div><div style="display:none;"> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_SearchTermText2">Inflammation (39249 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:10px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_814491935" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportEndSIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" value="600" type="text" /></td> </tr> </table><script id="dxss_1331245653" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:10px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_2046065225" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_1926633208" type="text/javascript">  </script><script id="dxss_228619664" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:20px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" type="hidden" value="1" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" value="Excel" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1509722775" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_960798088" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_835950349" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportedFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_308093146" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_424125632" type="text/javascript">  </script> </div> </div> </div> </div><b class="dx-clear"></b><table id="RootHolder_articleExportPopup_ExportFilePageControl_LP" class="dxtcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_TL">Loading…</span></td> </tr> </table><script id="dxss_2124675053" type="text/javascript">  </script> </div> </div><div class="dxpc-footer"> <div class="popup-footer-button-container"> <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles_I" class="dxb-hb" value="Export" type="submit" name="ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnExportArticles" /><span class="dx-vam">Export</span> </div> </div><script id="dxss_77486387" type="text/javascript">  </script>    <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnCancel" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_articleExportPopup_TPCFm1_btnCancel_I" class="dxb-hb" value="Cancel" type="submit" name="ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnCancel" /><span class="dx-vam">Cancel</span> </div> </div><script id="dxss_2118985763" type="text/javascript">  </script> </div> </div> </div> </div><div id="RootHolder_articleExportPopup_DXPWMB-1" 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All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA </div> <div class="scroll"> <a href="#top" target="_self"> <img src="/Contents/Images/backtop3.png" /> </a> </div> <div id="categorySelectorPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Select the Category</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="categorySelectorPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="categorySelectorPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="categorySelectorPopup_TL">Loading…</span></td> </tr> </table><div id="categorySelectorPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_166253781" type="text/javascript">  </script> <div id="pcLoginPopUp_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:700px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="pcLoginPopUp_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="pcLoginPopUp_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="pcLoginPopUp_TL">Loading…</span></td> </tr> </table><div id="pcLoginPopUp_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_430910140" type="text/javascript">  </script> <div id="aiComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:300px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Impact Index Per Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for Impact Index Per Article</b> </p> <p> Times Cited ÷ Number of Years = Impact Index Per Article<sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="aiComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="aiComputePopup_TL">Loading…</span></td> </tr> </table><div id="aiComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_698179129" type="text/javascript">  </script> <script type="text/javascript"> //<![CDATA[ var callBackFrameUrl='/WebResource.axd?d=beToSAE3vdsL1QUQUxjWdX-3aFLejnBliGvqSCZYULGFdxZmRlcJcqs71AKVNTQEXljNmd0slFkUZ_AFaCke4Q2&t=638628207619783110'; WebForm_InitCallback();//]]> </script> </form> </body> </html>