CINXE.COM

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5.1724696046-473375462.1712005244" style="margin: 0 10px;" target="_blank"><img alt="Novus Biologicals products are now on bio-techne.com" src="https://images.novusbio.com/design/ready-to-buy-novus-products-login.png" style="height:120px; width:940px" /></a></div> </div> </div> </div> <div class="clear"></div> <div class="ra-header"><img src="https://images.novusbio.com/design/bannerCancer04.jpg" class="ra-header" alt="Cancer" /></div> </div> <div class="main grid_4"> <div class="ra-menu"><ul><li class="active"><a href="/research-areas/cancer">Cancer</a></li><li><a href="/research-areas/cancer/angiogenesis">Angiogenesis</a></li><li><a href="/research-areas/cancer/cancer-stem-cells">Cancer Stem Cells</a></li><li><a href="/research-areas/cancer/dna-repair.html">DNA Repair</a></li><li><a href="/research-areas/cancer/extracellular-matrix.html">Extracellular Matrix</a></li><li><a href="/research-areas/cancer/metastasis">Metastasis</a></li><li><a href="/research-areas/cancer/mitotic-regulators.html">Mitotic Regulators</a></li><li><a href="/research-areas/cancer/oncogenes">Oncogenes</a></li><li><a href="/research-areas/cancer/ovarian-carcinoma-cell-markers.html">Ovarian Carcinoma Cell Markers</a></li><li><a href="/research-areas/cancer/resources">Resources</a></li><li><a href="/research-areas/cancer/tumor-suppressors.html">Tumor Suppressors</a></li></ul></div><div class="ra-publications"><div class="ra-left-header">Publications</div><div class="ra-left-body"><ul class="ra-publist"><li><a href="https://www.novusbio.com/support/mtor-signaling-poster" target="_blank"><img src="https://images.novusbio.com/design/publications-mtor-signaling.jpg" /></a></li><li><a href="https://www.novusbio.com/support/mapk-poster" target="_blank"><img src="https://images.novusbio.com/design/publications-mapk-signaling.jpg" /></a></li><li><a href="https://www.bio-techne.com/resources/literature/immunohistochemistry-ihc-handbook" target="_blank"><img src="https://images.novusbio.com/design/ihc_brochure-request-update-2022_v2.png" /></a></li></ul></div></div><div class="ra-charities"><div class="ra-left-header">Charities</div><div class="ra-left-body"><span class="ra-button-span"><a href="mailto:marketing@novusbio.com?subject=Charity%20Submission%20for%20Cancer" class="ra-button">Submit a Charity</a></span><div class="clear"></div></div></div><div class="ra-events"><div class="ra-left-header">Events</div><div class="ra-left-body"><p class="ra-events-blurb"><span class="ra-events-image"> </span>Submit your event on Cancer to be featured.</p><span class="ra-button-span"><a href="mailto:marketing@novusbio.com?subject=Event%20Submission%20for%20Cancer&body%3DEvent%20Name%3A%0ADescription%3A%0ADates%3A%0ATime%3A%0ALocation%3A%0AMore%20information%20URL%3A%0AImage%20%28please%20attach%20any%20relevant%20images%29" class="ra-button">Submit an Event</a></span><div class="clear"></div></div></div> </div> <div class="main grid_12"> <table cellpadding="6" cellspacing="6"> <tr> <td> <h2>Cancer Research Scope</h2> <p> Cancer encompasses a wide range of diseases where cellular proliferation goes unchecked leading to increased cell growth and decreased cell death. Genetic alterations, which may be inherited or result from environmental influence, represent the main basic underlying mechanism for disease onset and progression. Accelerated growth, programmed cell death evasion, immune checkpoint evasion and ability to invade distant tissues are all hallmark properties of cancerous cells. These abnormal cellular properties are brought about by mutations in genes involved in the regulation of cell proliferation and growth, including proto-oncogenes and tumor suppressor genes. Additionally, mutations in genes involved in DNA repair further undermine the integrity of DNA sequences facilitating the accumulation of multiple DNA lesions in cancer cells. </p> <br/> <p align="center"><a href="/antibody-news/category/cancer" class="link_button">Read about Current Cancer Topics</a> </p> <br/> <br/> <p>Traditionally, cancer types have been identified based on the site of origin and afflicted organ or tissue. In the US, prostate and breast cancer represent the most prevalent cancer types afflicting males and females, respectively. It is also noteworthy that lung cancer causes ~25% of cancer-related deaths in both males and females. Lung cancer causes more deaths annually than breast, prostate, and colon cancer combined.</p> <h2>Explore Antibodies by Cancer Type</h2> <table align="center" border="0" cellpadding="4" cellspacing="4" width="700px" class="alternate blueTop wide withGrid"> <tr valign="middle"> <td><img src="https://images.novusbio.com/design/brain-02.png" alt="" width="20"> Brain - <a href="/search?keywords=novus&category=Primary%20Antibodies&related_diseases=Glioma">Glioma</a> </td> <td><img src="https://images.novusbio.com/design/prostate-02.png" alt="" width="20"> Genital system - <a href="/search?keywords=novus&category=Primary%20Antibodies&related_diseases=Prostatic%20Neoplasms">Prostate Cancer</a></td> <td><img src="https://images.novusbio.com/design/oral-02.png" alt="" width="20"> Oral cavity & pharynx - <a href="/search?keywords=novus&category=Primary Antibodies&related_diseases=Mouth Neoplasms">Mouth Neoplasm </a></td> </tr> <tr valign="middle"> <td><img src="https://images.novusbio.com/design/breast-02.png" alt="" width="20" > Breast - <a href="/search?keywords=novus&category=Primary%20Antibodies&related_diseases=Ductal%20Breast%20Carcinoma">Ductal Breast Carcinoma</a></td> <td><img src="https://images.novusbio.com/design/leukemia-02.png" alt="" width="20"> Leukemia - <a href="/search?keywords=novus&category=Primary%20Antibodies&related_diseases=Acute%20Lymphocytic%20Leukemia">Acute Lymphocytic Leukemia</a></td> <td><img src="https://images.novusbio.com/design/lung-02.png" alt="" width="20"> Respiratory system - <a href="/search?keywords=novus&category=Primary Antibodies&related_diseases=Malignant Neoplasm Of Lung">Lung Malignant Neoplasm </a></td> </tr> <tr valign="middle"> <td><img src="https://images.novusbio.com/design/colon-02.png" alt="" width="20" > Digestive system - <a href="/search?keywords=novus&category=Primary Antibodies&related_diseases=Colorectal Cancer">Colorectal Cancer </a></td> <td><img src="https://images.novusbio.com/design/lymphoma-02.png" alt="" width="20"> Lymphoma - <a href="/search?keywords=novus&category=Primary Antibodies&related_diseases=Hodgkin Disease"> Hodgkin Disease</a></td> <td><img src="https://images.novusbio.com/design/skin-02.png" alt="" width="20"> Skin - <a href="/search?keywords=novus&category=Primary%20Antibodies&related_diseases=Melanoma">Melanoma</a></td> </tr> <tr valign="middle"> <td><img src="https://images.novusbio.com/design/endocrine-02.png" alt="" width="20"> Endocrine system - <a href="/search?keywords=novus&category=Primary%20Antibodies&related_diseases=Malignant%20Neoplasm%20Of%20Pancreas"> Pancreas Malignant Neoplasm</a></td> <td><img src="https://images.novusbio.com/design/myeloma-02.png" alt="" width="20" > Myeloma - <a href="/search?keywords=novus&category=Primary%20Antibodies&related_diseases=Multiple%20Myeloma">Multiple Myeloma</a> </td> <td><img src="https://images.novusbio.com/design/kidney-02.png" alt="" width="20"> Urinary system - <a href="/search?keywords=novus&category=Primary%20Antibodies&related_diseases=Renal%20Cell%20Carcinoma">Renal Cell Carcinoma</a></td> </tr> </table> <br/><br/> <table align="center" border="1" cellpadding="4" cellspacing="4" style="margin-left:auto; margin-right:auto; width:700px"> <tbody> <tr align="center" bordercolor="#000;"> <td> <p><a href="/explorer#!bv_gid=d11a321bb7c7226a17ca34f32ffe28c5">Melanoma</a> 92%<br> <img src="https://images.novusbio.com/design/melanoma-cr.jpg" alt="MCAM/CD146 expression in human melanoma tissue , IHC" width="110"><br> <a href="/products/mcam-cd146-antibody_af932">MCAM/CD416</a></p> </td> <td rowspan="3"> <img src="https://images.novusbio.com/design/cancer-graph-2.jpg" alt="Antibodies by cancer type available at Novus Biologicals, IHC" width="500"> </td> <td> <p><a href="/diseases/stage-colon-cancer">Colon</a> 30%<br><img src="https://images.novusbio.com/design/colon-cr2.jpg" alt="APC expression in human colon cancer tissue , IHC" width="110"><br> <a href="/products/apc-antibody_nb100-91662">APC</a></p> </td> </tr> <tr align="center" bordercolor="#000;"> <td> <p><a href="/diseases/metastatic-renal-cell-cancer">Kidney</a> 43%<br> <img src="https://images.novusbio.com/design/kidney-cr.jpg" alt="Neprilysin/CD10 expression in human kidney, IHC" width="110"><br> <a href="/products/neprilysin-cd10-antibody-715820_mab11821">Neprilysin</a></p> </td> <td> <p><a href="/diseases/stage-prostate-cancer">Prostate</a> 58%<br> <img src="https://images.novusbio.com/design/prostate-cr.jpg" alt="Kallikrein 3/PSA expression in prostate cancer tissue, IHC" width="110"><br> <a href="/products/kallikrein-3-psa-antibody-181823_mab1344">Kallikrein</a></p> </td> </tr> <tr align="center" bordercolor="#000;"> <td> <p><a href="/diseases/stage-nonsmall-cell-lung-cancer">Lung</a> 92%<br><img src="https://images.novusbio.com/design/lung-cr.jpg" alt="Survivin expression in human lung cancer tissue , IHC" width="110"><br> <a href="/products/survivin-antibody-321_nb500-237">Survivin</a></p> </td> <td> <p><a href="/diseases/bilateral-breast-cancer">Breast</a><br> <img src="https://images.novusbio.com/design/breast-cr.jpg" alt="Brca1 expression in human breast cancer tissue, IHC" width="110"><br> <a href="/products/brca1-antibody-440621_mab22101">Brca1</a></p> </td> </tr> <tr> <td colspan="3"> <p style="font-size:12px;"> <i>*Estimated Number of New Cancer Cases, US, 2018. Estimated new cases are based on 2000-2014 incidence data from the North American Association of Central Cancer Registries (NAACCR). : <a href="https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/annual-cancer-facts-and-figures/2018/cancer-facts-and-figures-2018.pdf" target="_blank">https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/annual-cancer-facts-and-figures/2018/cancer-facts-and-figures-2018.pdf</a></i></p> </td> </tr> </tbody> </table> <br/><br/> <p align="center"><a href="/research-area/Cancer" class="link_button">Find All Cancer Products</a> </p> <br/> <br/> <table align="center" border="0" cellpadding="4" cellspacing="4" width="700px" class="alternate blueTop wide withGrid"> <tr align="center"> <th width="153"> <p>Cancer Related Proteins</p> </th> <th width="208"> <p>Cancer Type</p> </th> <th width="299"> <p>Function</p> </th> </tr> <tr> <td> <p><a href="/common-name/apc">APC</a> (adenomatous polyposis coli)*</p> </td> <td> <p>Colorectal cancer: familial adenomatous polyposis (FAP)</p> <p>Colorectal cancer and medulloblastoma: Turcot syndrome</p> <p>Gastric cancer </p> </td> <td> <p>Tumor suppressor frequently mutated in FAP, a progressive condition characterized by the development of abundant polyps in the colon leading to colorectal cancer. Mutations in APC commonly lead to a C-terminal truncated product, affecting the interaction of APC with <a href="/common-name/beta-catenin">beta-catenin</a> and microtubules.</p> </td> </tr> <tr> <td> <p><a href="/common-name/kallikrein-3-psa">Kallikrein-3/PSA</a> (Prostate specific antigen: PSA)</p> </td> <td> <p>Prostate cancer</p> </td> <td> <p>Serine protease with abnormal expression in prostate cancer and used as biomarker for disease diagnosis and monitoring. The expression of other Kallikrein family members (e.g., <a href="/common-name/kallikrein-2">KLK 2</a>, <a href="/common-name/kallikrein-4-prostase-emsp1">KLK 4</a>, <a href="/common-name/kallikrein-11">KLK 11</a>, <a href="/common-name/kallikrein-14">KLK 14</a>, <a href="/common-name/kallikrein-15">KLK 15</a>) is upregulated in prostate cancer.</p> </td> </tr> <tr> <td> <p><a href="/common-name/brca1">BRCA1</a> (breast cancer early-onset 1)</p> </td> <td> <p>Breast cancer</p> <p>Ovarian carcinoma</p> </td> <td> <p>Tumor suppressor involved in control of DNA replication and repair. Reduced <a href="/common-name/brca1">BRCA1</a> and <a href="/common-name/brca2">BRCA2</a> expression is associated with breast and ovarian tumorigenesis. Increased <a href="/nfkbpathway">NFKb</a> activation is associated with proliferation of BRAC1 deficient mammary progenitor cells.</p> </td> </tr> <tr> <td> <p><a href="/common-name/survivin">Survivin</a> (baculoviral IAP repeat-containing 5/ BIRC5)</p> </td> <td> <p>Lung cancer<p/> <p>Breast cancer<p/> <p>Oesophageal cancer </p> </td> <td> <p>Inhibitor of cell death that belongs to the IAP family (e.g., <a href="/common-name/xiap">XIAP</a>, <a href="/products/ciap-pan-antibody-315301_mab3400">cIAP</a> and <a href="/common-name/naip">NAIP</a>). Cell death inhibition is mediated via caspase-dependent and independent mechanisms. Survivin is overexpressed in most cancer types.</p> </td> </tr> <tr> <td> <p><a href="/common-name/neprilysin-cd10">Neprilysin/CD10</a> (neutral endopeptidase)</p> </td> <td> <p>Prostate cancer<p/> <p>Pancreas cancer<p/> <p>Lung cancer</p> </td> <td> <p>Cell surface expressed zinc metallopeptidase involved in the processing of several peptides (e.g., neuropeptides and inflammatory peptides). Neprilysin serves as a biomarker for acute lymphoblastic leukemia, hepatocellular carcinoma and clear cell renal carcinoma.</p> </td> </tr> <tr> <td> <p><a href="/common-name/mcam-cd146">MCAM/CD146</a> (Melanoma-associated antigen MUC18)</p> </td> <td> <p>Prostate cancer<p/> <p>Melanoma<p/> <p>Pancreatic cancer<p/> <p>Hepatocellular carcinoma<p/> <p>Breast cancer </p> </td> <td> <p>Transmembrane glycoprotein involved in endothelial cell adhesion. Overexpression of MCAM is associated with increased metastasis in prostate cancer. In triple-negative breast cancer, MCAM overexpression promotes EMT through <a href="/common-name/rhoa">RhoA</a> signaling and induced <a href="/common-name/slug">Slug</a> expression.</p> </td> </tr> </table> <p style="font-size:12px;"><a href="https://ghr.nlm.nih.gov/gene/APC" target="_blank">*APC gene: https://ghr.nlm.nih.gov/gene/APC#conditions</a></p> <br/><br/> <p><b>Select References</b><br/><br/> Aoki, K., & Taketo, M. M. (2007). <a href="https://www.ncbi.nlm.nih.gov/pubmed/17881494" target="_blank">Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene</a>. Journal of Cell Science. <a href="https://doi.org/10.1242/jcs.03485" target="_blank">https://doi.org/10.1242/jcs.03485</a></p> <p>Fuhrman-Luck, R. A., Loessner, D., & Clements, J. A. (2014). <a href="https://www.semanticscholar.org/paper/Kallikrein-Related-Peptidases-in-Prostate-Cancer%3A-Fuhrman-Luck-Loessner/7c082cd2457dff7aad4aeeafd0043fe83562b37c" target="_blank">Kallikrein-Related Peptidases in Prostate Cancer: From Molecular Function to Clinical Application</a>. EJIFCC. PMCID: PMC4975200</p> <p>Goldar, S., Khaniani, M. S., Derakhshan, S. M., & Baradaran, B. (2015). <a href="https://pdfs.semanticscholar.org/52a1/0aebd517be62fe6cbca80664d1a4f18f0dde.pdf" target="_blank">Molecular mechanisms of apoptosis and roles in cancer development and treatment.</a> Asian Pacific Journal of Cancer Prevention. <a href="https://doi.org/10.7314/APJCP.2015.16.6.2129" target="_blank">https://doi.org/10.7314/APJCP.2015.16.6.2129</a></p> <p>Hassanpour, S. H., & Dehghani, M. (2017). <a href="https://www.researchgate.net/publication/318347992_Review_of_cancer_from_perspective_of_molecular" target="_blank">Review of cancer from perspective of molecular</a>. Journal of Cancer Research and Practice. <a href="https://doi.org/10.1016/j.jcrpr.2017.07.001" target="_blank">https://doi.org/10.1016/j.jcrpr.2017.07.001</a></p> <p>Jaiswal, P. K., Goel, A., & Mittal, R. D. (2015). <a href="https://www.researchgate.net/publication/279302299_Survivin_A_molecular_biomarker_in_cancer" target="_blank">Survivin: A molecular biomarker in cancer</a>. Indian Journal of Medical Research. <a href="https://doi.org/10.1002/stem.592" target="_blank">https://doi.org/10.1002/stem.592</a></p> <p>Maguer-Satta, V., Besançon, R., & Bachelard-Cascales, E. (2011). <a href="https://www.ncbi.nlm.nih.gov/pubmed/21425402" target="_blank">Concise review: Neutral endopeptidase (CD10): A multifaceted environment actor in stem cells, physiological mechanisms, and cancer</a>. Stem Cells. <a href="https://doi.org/10.1002/stem.592" target="_blank">https://doi.org/10.1002/stem.592</a></p> <p>Sau, A., Lau, R., Cabrita, M. A., Nolan, E., Crooks, P. A., Visvader, J. E., & Pratt, M. A. C. (2016). <a href="https://www.ncbi.nlm.nih.gov/pubmed/27292187" target="_blank">Persistent Activation of NF-κB in BRCA1-Deficient Mammary Progenitors Drives Aberrant Proliferation and Accumulation of DNA Damage</a>. Cell Stem Cell. <a href="https://doi.org/10.1016/j.stem.2016.05.003" target="_blank">https://doi.org/10.1016/j.stem.2016.05.003</a></p> <p>Yang, D., Wu, Z., Duan, H., Luo, Y., Lu, D., Li, W., … Yan, X. (2011). <a href="https://www.researchgate.net/publication/51973434_CD146_an_epithelial-mesenchymal_transition_inducer_is_associated_with_triple-negative_breast_cancer" target="_blank">CD146, an epithelial-mesenchymal transition inducer, is associated with triple-negative breast cancer</a>. Proceedings of the National Academy of Sciences. <a href="https://doi.org/10.1073/pnas.1111053108" target="_blank">https://doi.org/10.1073/pnas.1111053108</a></p> <p>Zamay, T. N., Zamay, G. S., Kolovskaya, O. S., Zukov, R. A., Petrova, M. M., Gargaun, A., … Kichkailo, A. S. (2017). <a href="https://www.researchgate.net/publication/321045814_Current_and_Prospective_Protein_Biomarkers_of_Lung_Cancer" target="_blank">Current and prospective protein biomarkers of lung cancer</a>. Cancers. <a href="https://doi.org/10.3390/cancers9110155" target="_blank">https://doi.org/10.3390/cancers9110155</a></p> <br/> <br/> </td> </tr> </table><div class="ra-product-block"></div> </div> </div> <div id="novus_footer_line"></div>  </div> <div class="container_16"> <div id="footer"> <div class="grid_16 text_center"> <div class="fp_horzline"></div> </div> <div class="clear"></div> <div class="grid_16"> <table class="footer_boxes"> <tr> <th>Popular Products</th> <th>Company Information</th> <th>Support</th> <th>Stay Connected</th> </tr> <tr> <td> <ul class='links'><li><a href="/productsearch/novus">Antibodies</a></li><li><a href="/product-type/secondary-antibodies">Secondary Antibodies</a></li><li><a href="/product-type/isotype-controls">Isotype Controls</a></li><li><a href="/product-type/peptides-and-proteins">Proteins and Peptides</a></li><li><a href="/product-type/elisa-kits">ELISA Kits</a></li><li><a href="/samplesize">Sample Size</a></li><li><a href="https://www.novusbio.com/new-product-information-page.html">New Products</a></li> </ul> </td> <td> <ul class='links'><li><a href="/about.html">About Us</a></li><li><a href="https://www.bio-techne.com/about/careers">Careers</a></li><li><a href="/guarantee">Novus Guarantee</a></li><li><a href="/about/contact-us.html">Contact Us</a></li><li><a href="/about/novus-team.html">Our Team</a></li> </ul> </td> <td> <ul class='links'><li><a href="/support/technical-support.html">Technical Support</a></li><li><a href="/support/faqs.html">FAQs</a></li><li><a href="/webform/help-finding-antibodies">Help Finding Antibodies</a></li><li><a href="/support/support-by-application.html">Protocols</a></li> </ul> </td> <td id="footer_social_links"> </td> </tr> </table> </div> <div class="clear"></div> <div class="grid_16"> <div id="GTS_CONTAINER" style="float: right;margin-top: 10px;"></div> <div id="footer_officeinfo"> </div> <div class="fp_horzline"></div> <div class="footer_othersites"> <p>Visit our other sites</p> <a href="https://www.bio-techne.com/" target="_blank"><div class="fp_biotechne"></div></a> <a href="https://www.rndsystems.com/"><div class="fp_rnd"></div></a> <a href="https://www.novusbio.com/" target="_blank"><div class="fp_novus"></div></a> <a href="https://www.tocris.com/" target="_blank"><div class="fp_tocris"></div></a> <a href="https://www.bio-techne.com/brands/proteinsimple" target="_blank"><div class="fp_proteinSimple"></div></a> <a href="http://www.biospacific.com/" target="_blank"><div class="fp_biospacific"></div></a>  <a href="http://www.acdbio.com/" target="_blank"><div class="fp_acd"></div></a> <a href="https://www.rndheme.com/" target="_blank"><div class="fp_rndcc"></div></a> </div> <div class="text_center"> <div class="fp_horzline"></div> </div> <div class="copyright">©2024 Novus Biologicals, All Rights Reserved.</div> <div class="footer_legal"> <ul class="links"><li class="menu-47946 first"><a href="/support/customer-service/privacy-policy.html" title="">Privacy Policy</a></li> <li class="menu-47956"><a href="/novus-bio-sitemap.html" title="">Sitemap</a></li> <li class="menu-47951"><a href="/about/contact-us.html" title="">Contact Us</a></li> <li class="menu-47941 last"><a href="/support/customer-service/terms.html" title="">Terms & Conditions</a></li> </ul> </div> <div class="clear"></div> </div> </div> </div> <script type="text/javascript"> <![CDATA[//><!]]> </script> <script type="text/javascript">window.NREUM||(NREUM={});NREUM.info={"beacon":"bam.nr-data.net","licenseKey":"76fb58fb05","applicationID":"788348554,30870807","transactionName":"YFdbZBFZXxdWAhAMVlkdeFMXUV4KGA8LAVxoQlhXBmdHDVIW","queueTime":24,"applicationTime":257,"atts":"TBBYEllDTBk=","errorBeacon":"bam.nr-data.net","agent":""}</script></body> </html>