Survivin Research Products: Novus Biologicals

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id="block-et-messages-et-messages-block" class="block block-et-messages"> <div class="content"> <span></span> </div> </div> <div id="block-system-main" class="block block-system"> <div class="content"> <div class="grid_4"> <div id="cnlpCategoriesContainer"> <div id="cnlpCategories"><div><a href="#prodAntibodies">Survivin Antibodies (28)</a></div><div><a href="#prodAntibody+Packs">Survivin Antibody Pack (1)</a></div><div><a href="#prodELISA+Kits">Survivin ELISA Kits (2)</a></div><div><a href="#prodLysates">Survivin Lysate (1)</a></div><div><a href="#prodProteins">Survivin Proteins (4)</a></div> </div> </div> </div> <div id="equalize"> <div class="grid_12 new-search-result_col3" id="cnlpProdWindow"><a id="prodAntibodies"></a><div class="prodHeader">Antibodies</div> <div class="cnlpProds"> <div class="cnlpProd"> <div class="cnlpProdTop"> <div class="prodBanner">  <div class="catalog_number"> <a class="ecommerce_link" data-id="NB500-201" data-brand="novus" data-name="Survivin Antibody - BSA Free" data-position="1" href="/products/survivin-antibody_nb500-201" title="Survivin Antibody - BSA Free">Survivin Antibody - BSA Free</a> <div style="display:none;">Survivin Antibody - BSA Free</div> </div> </div> <div class="prodContainer"> <div class="flourish left"></div> <div class="prodImages"> <div>NB500-201</div> <div class="cnlpImages"><div class="images"><div id="ss_prev0NB500-201" class="cycle-pager"><div class="pager_left_on"></div></div><div class="cycle-slideshow slideshows" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-0NB500-201" data-cycle-prev="#ss_prev0NB500-201" data-cycle-next="#ss_next0NB500-201" data-cycle-caption="#image-caption0NB500-201" data-cycle-caption-template="Image {{slideNum}} of {{slideCount}}" data-cycle-slides=".big_thumb_container" ><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/Survivin-Antibody-Dual-RNAscope-ISH-IHC-NB500-201-img0026.jpg" title="Dual RNAscope ISH-IHC: Survivin Antibody [NB500-201] - Formalin-fixed paraffin-embedded tissue sections of human esophagus squamous cell carcinoma were probed for Survivin mRNA (ACD RNAScope Probe, [465361]; Fast Red chromogen, ACD [322360]). Adjacent tissue section was processed for immunohistochemistry using rabbit polyclonal [NB500-201] at 1.5ug/mL with overnight incubation at 4 degrees Celsius followed by incubation with anti-rabbit IgG VisUCyte HRP Polymer Antibody [VC003] and DAB chromogen (yellow-brown). Tissue was counterstained with hematoxylin (blue). Specific staining was localized to tumor cells." class="big_lightbox" target="_blank"> <img src="//images.novusbio.com/images/Survivin-Antibody-Dual-RNAscope-ISH-IHC-NB500-201-img0026.jpg" alt="Dual RNAscope ISH-IHC Survivin Antibody - BSA Free" class="big_thumb" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/Survivin-Antibody-Knockdown-Validated-NB500-201-img0037.jpg" title="Western Blot: Survivin Antibody [NB500-201] - Western blot analysis using Survivin and flotillin antibodies was performed on lysates of DMSO- and PTX-treated MDAMB231 cells ectopically expressing either control siRNA or Survivin siRNA (panels labeled WCL), as well as on the exosomes these cells generated (panels labeled Exos). Image collected and cropped by CiteAb from the following publication (//www.mdpi.com/2072-6694/8/12/111) licensed under a CC-BY license." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/Survivin-Antibody-Knockdown-Validated-NB500-201-img0037.jpg" alt="Western Blot Survivin Antibody - BSA Free" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/Survivin-Antibody-Immunohistochemistry-NB500-201-img0038.jpg" title="Immunohistochemistry: Survivin Antibody [NB500-201] - Protein expression pattern of Survivin in HCC tissues and non-neoplastic liver parenchyma. IAP members immunoreactivity was estimated by tissue microarray in a subset of HCC patients (n = 40). A-D, Representative Survivin cytoplasmatic immunostaining in a tumor core (A), in a tumor proximal to cirrhosis (C, N: cirrhosis, K: HCC), and in adjacent and long-distance non-neoplastic parenchyma (B and D, respectively). Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/19397802) licensed under a CC-BY license." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/Survivin-Antibody-Immunohistochemistry-NB500-201-img0038.jpg" alt="Immunohistochemistry Survivin Antibody - BSA Free" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/Survivin-Antibody-Knockdown-Validated-NB500-201-img0033.jpg" title="Knockdown Validated: Survivin Antibody [NB500-201] - Anti-tumor effects and functional evidence of sCA-survivin-siRNA in HCT116 and HT29 solid tumor models. Immunostaining of survivin in the tumor tissues on day 19 using [NB500-201]. Scale bar, 50 um. Image collected and cropped by CiteAb from the following publication (//dx.plos.org/10.1371/journal.pone.0116022) licensed under a CC-BY license." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/Survivin-Antibody-Knockdown-Validated-NB500-201-img0033.jpg" alt="Knockdown Validated Survivin Antibody - BSA Free" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/Survivin-Antibody-Immunocytochemistry-Immunofluorescence-NB500-201-img0018.jpg" title="Immunocytochemistry/Immunofluorescence: Survivin Antibody [NB500-201] - Analysis using the HRP conjugate of [NB500-201]. Staining of Telophase with accumulation of survivin in the midbodies of two daughter cells. Survivin detection using [NB500-201]." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/Survivin-Antibody-Immunocytochemistry-Immunofluorescence-NB500-201-img0018.jpg" alt="Immunocytochemistry/ Immunofluorescence Survivin Antibody - BSA Free" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/Survivin-Antibody-Western-Blot-NB500-201-img0017.jpg" title="Western Blot: Survivin Antibody [NB500-201] - Analysis of 30ug of HeLa whole cell lysate [NB800-PC1] using rabbit polyclonal [NB500-201] at 1ug/ml. Detection was performed using ECL method with 1 minute exposure. Band detected at higher molecular weight than the predicted MW (16 kDa)." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/Survivin-Antibody-Western-Blot-NB500-201-img0017.jpg" alt="Western Blot Survivin Antibody - BSA Free" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/Survivin-Antibody-Immunohistochemistry-Paraffin-NB500-201-img0008.jpg" title="Immunohistochemistry-Paraffin: Survivin Antibody [NB500-201] - Immunohistochemical staining of Survivin in human rectal cancer using [NB500-201] and DAB with hematoxylin counterstain." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/Survivin-Antibody-Immunohistochemistry-Paraffin-NB500-201-img0008.jpg" alt="Immunohistochemistry-Paraffin Survivin Antibody - BSA Free" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/Survivin-Antibody-Flow-Cytometry-NB500-201-img0025.jpg" title="Flow Cytometry: Survivin Antibody [NB500-201] - An intracellular stain was performed on HeLa cells with [NB500-201] and a matched isotype control. Cells were fixed with 4% PFA and then permeablized with 0.1% saponin. Cells were incubated in an antibody dilution of 2.5 ug/mL for 30 minutes at room temperature, followed by Rabbit IgG (H+L) Cross-Adsorbed Secondary Antibody, Dylight 550." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/Survivin-Antibody-Flow-Cytometry-NB500-201-img0025.jpg" alt="Flow Cytometry Survivin Antibody - BSA Free" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/Survivin-Antibody-Western-Blot-NB500-201-img0032.jpg" title="Western Blot: Survivin Antibody [NB500-201] - Western blot analysis using Survivin Antibody [NB500-201]. Effects of siRNA transfection on the expression of Bcl-xL and survivin. Bcl-xL and survivin protein content detected by Western Blotting 48 h after transfection. Bcl-xL and survivin levels are shown normalized to the reference protein beta-actin and relative to the ns-si control. Image collected and cropped by CiteAb from the following publication (//www.mdpi.com/1422-0067/14/6/12297) licensed under a CC-BY license." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/Survivin-Antibody-Western-Blot-NB500-201-img0032.jpg" alt="Western Blot Survivin Antibody - BSA Free" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/Survivin-Antibody-Western-Blot-NB500-201-img0013.jpg" title="Western Blot: Survivin Antibody [NB500-201] - Analysis of Survivin in human hepatocytes from cancer patient (left) and HeLa cell lysate (right) using [NB500-201]. Image from verified customer review. Note: bands detected at higher molecular weight than predicted (16 kDa)" class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/Survivin-Antibody-Western-Blot-NB500-201-img0013.jpg" alt="Western Blot Survivin Antibody - BSA Free" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/nb500-201_rabbit-polyclonal-survivin-antibody-310202416171444.jpg" title="Western Blot: Survivin Antibody [NB500-201] - Western blot analysis using [NB500-201]. Survivin protein is degraded by ubiquitin proteasome in serum-free and serum-containing media. Western blots and protein quantitation graphs showing that addition of MG-132 proteasome inhibitor (10 uM) extended survivin protein half-life in serum-free and serum-containing media. One representative western blot out of triplicate experiments was shown for each treatment and condition. *Indicates the time at which survivin protein is half of the amount at 0 hours (half-life), P 100. ** p-value 100. ** p-value < .01 using student t-test. H. PFGE analysis of EBV episomes & linears at 7 days post-transduction with lentivirus shRNA for shControl or shSurvivin in MUTU I or RAJI cell lines. Human alpha satellite DNA is used for DNA loading control Western blot of Survivin & Actin are shown below for each cell at 7 days post-transduction. Image collected & cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/28077791), licensed under a CC-BY license. Not internally tested by Novus Biologicals." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/nb500-201_rabbit-polyclonal-survivin-antibody-310202416171444.jpg" alt="Proximity Ligation Assay Survivin Antibody - BSA Free" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/nb500-201_rabbit-polyclonal-survivin-antibody-310202416182643.jpg" title="Western Blot: Survivin Antibody - BSA Free [NB500-201] - The p53-p21 axis facilitates downregulation of survivin via cell cycle(A) HCT116 wild typeand p21-deficient (p21-/-) cells were treated with 5 μM L-OHP for 24 hours. Whole cell lysates were analyzed with antibodies against p53, p21, & survivin; vinculin serves as loading control. (B) Cell cycle distribution was analyzed after 24 hours treatment by flow cytometry analysis (n = 3). (C) To induce p21, RKO p21ind cells were treated with 3 nM Muristerone A for 24 hours & tested for the levels of p21 & survivin; vinculin, loading control. (D)BIRC5 mRNA levels were analyzed by quantitative real-time PCR after 24 hours treatment with MurA in RKO p21ind cells (n = 3). (E) Cell cycle distribution was measured by flow cytometry analyses of cellular DNA content (n = 3). (F) Scheme summarizing the supposed mechanisms of survivin regulation after L-OHP & CPT-11 treatment. Image collected & cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/29963241), licensed under a CC-BY license. Not internally tested by Novus Biologicals." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/nb500-201_rabbit-polyclonal-survivin-antibody-310202416182643.jpg" alt="Western Blot Survivin Antibody - BSA Free" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/nb500-201_rabbit-polyclonal-survivin-antibody-310202416175291.jpg" title="Western Blot: Survivin Antibody - BSA Free [NB500-201] - Apoptosis & survival signaling after L-OHP & CPT-11(A) Western blot analysis using antibodies against p53 & pro-apoptotic BAX & PIG-3 after treatment with 5 μM L-OHP or 10 μM CPT-11. (B) Immunodetection of NF-kappa B p65, RELB & anti-apoptotic survivin, XIAP, BCL-XL & MCL1; vinculin serves as loading control. (C) Effects of increasing doses L-OHP & CPT-11 on caspase-3 & PARP1 cleavage after 24 hours treatment; alpha -tubulin serves as loading control. (D) Cells were treated with a combination of L-OHP & the caspase-inhibitor Z-VAD-FMK (50 μM). Immunodetection of survivin, p53 & full-length caspase-3 was conducted. Detection of apoptosis was determined by cleavage products of caspase-3 & PARP1; beta -actin serves as loading control. Please note: Figure 4A & 4B, as well as Supplementary Figure 2A show signals acquired by different detection methods, but originate from the same Western blots. This is due to a switch in the immunoblot chemiluminescence detection system from X-ray films (darker background) to a CCD camera system (Fusion Solo S, Vilber Lourmat; lighter background). Image collected & cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/29963241), licensed under a CC-BY license. Not internally tested by Novus Biologicals." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/nb500-201_rabbit-polyclonal-survivin-antibody-310202416175291.jpg" alt="Western Blot Survivin Antibody - BSA Free" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/nb500-201_rabbit-polyclonal-survivin-antibody-310202416175225.jpg" title="Western Blot: Survivin Antibody - BSA Free [NB500-201] - Anti-tumor effects & functional evidence of sCA-survivin-siRNA in HCT116 & HT29 solid tumor models.(A) For western blot analysis, HCT116 cells were seeded into 6-well plates & transfected with 100 pmol/well of either control or survivin siRNA by Lp (Lipofectamine 2000) or sCA. Actin blots served as loading controls. (B) For proliferation assays, cells were uniformly seeded into 96-well plates (1 × 104 cells/well), & 5 pmol/well siRNA was used. Cell viability was examined at 48 & 72 h by WST-8 assay. Data represent mean ± SEM. *P = 0.0294, **P = 0.0304 (n = 4, Wilcoxon rank test). (C) In vivo tumor growth. Each vehicle, carrying 15 μg of control siRNA or survivin siRNA, was administered by intravenous injection to mice with HCT116 tumors. Data represent the mean ± SEM (n = 10 tumors, Wilcoxon rank test). (D) Immunostaining of survivin in the tumor tissues on day 19. Scale bar, 50 μm. (E) In vivo live imaging of sCA-siRNA (6-FAM labeled) in HT29 tumor by multiphoton microscopy at 90 min. (F) Fluorescent detection of naked-siRNA (6-FAM labeled) or sCA-siRNA (6-FAM labeled) in the HT29 tumor at 4 h. Green: 6-FAM labeled siRNA; Red: microvasculature; Blue: DAPI stained nuclei. Scale bar, 50 μm. (G) Mice were administered with 40 μg of naked-survivin-siRNA or sCA-survivin-siRNA on days 0, 1, & 2. Tumors were removed on day 3, & western blot analysis for survivin was performed. (H) Many tumor cells treated with sCA-survivin-siRNA (6-FAM labeled) had condensed nuclei & were positive for TUNEL assay. Scale bar, 50 μm. Image collected & cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/25738937), licensed under a CC-BY license. Not internally tested by Novus Biologicals." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/nb500-201_rabbit-polyclonal-survivin-antibody-310202416175225.jpg" alt="Western Blot Survivin Antibody - BSA Free" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/nb500-201_rabbit-polyclonal-survivin-antibody-310202416161820.jpg" title="Western Blot: Survivin Antibody - BSA Free [NB500-201] - Survivin is essential for the salinomycin-induced apoptosis in UM cells. a UM cells were treated with salinomycin for 24 h & the protein levels of apoptosis-related proteins were detected by Western blot. b & c UM cells were transduced with lentiviral pTSB-Survivin cDNA (b), Survivin-shRNA constructs (c), or their corresponding empty vectors, & then incubated in the presence of puromycin (1 μg/mL) for 5 days to reach stable clones. Such survivin-manipulated cells were then exposed to salinomycin for 24 h, & subjected to trypan blue exclusion assay (left) & Western blot assay (right). Data represent mean ± SD. ns, not significant; *, P < 0.05; **, P < 0.01; ***, P < 0.001, Student’s t test. d qRT-PCR analysis of BIRC5 mRNA level was done in the 92.1 & Mel270 cells treated with salinomycin for 24 h. **, P < 0.01; ***, P < 0.001, one-way ANOVA, post hoc comparisons, Tukey’s test Image collected & cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/31718679), licensed under a CC-BY license. Not internally tested by Novus Biologicals." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/nb500-201_rabbit-polyclonal-survivin-antibody-310202416161820.jpg" alt="Western Blot Survivin Antibody - BSA Free" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/nb500-201_rabbit-polyclonal-survivin-antibody-310202416182634.jpg" title="Immunocytochemistry/ Immunofluorescence: Survivin Antibody - BSA Free [NB500-201] - Anti-tumor effects & functional evidence of sCA-survivin-siRNA in HCT116 & HT29 solid tumor models.(A) For western blot analysis, HCT116 cells were seeded into 6-well plates & transfected with 100 pmol/well of either control or survivin siRNA by Lp (Lipofectamine 2000) or sCA. Actin blots served as loading controls. (B) For proliferation assays, cells were uniformly seeded into 96-well plates (1 × 104 cells/well), & 5 pmol/well siRNA was used. Cell viability was examined at 48 & 72 h by WST-8 assay. Data represent mean ± SEM. *P = 0.0294, **P = 0.0304 (n = 4, Wilcoxon rank test). (C) In vivo tumor growth. Each vehicle, carrying 15 μg of control siRNA or survivin siRNA, was administered by intravenous injection to mice with HCT116 tumors. Data represent the mean ± SEM (n = 10 tumors, Wilcoxon rank test). (D) Immunostaining of survivin in the tumor tissues on day 19. Scale bar, 50 μm. (E) In vivo live imaging of sCA-siRNA (6-FAM labeled) in HT29 tumor by multiphoton microscopy at 90 min. (F) Fluorescent detection of naked-siRNA (6-FAM labeled) or sCA-siRNA (6-FAM labeled) in the HT29 tumor at 4 h. Green: 6-FAM labeled siRNA; Red: microvasculature; Blue: DAPI stained nuclei. Scale bar, 50 μm. (G) Mice were administered with 40 μg of naked-survivin-siRNA or sCA-survivin-siRNA on days 0, 1, & 2. Tumors were removed on day 3, & western blot analysis for survivin was performed. (H) Many tumor cells treated with sCA-survivin-siRNA (6-FAM labeled) had condensed nuclei & were positive for TUNEL assay. Scale bar, 50 μm. Image collected & cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/25738937), licensed under a CC-BY license. Not internally tested by Novus Biologicals." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/nb500-201_rabbit-polyclonal-survivin-antibody-310202416182634.jpg" alt="Immunocytochemistry/ Immunofluorescence Survivin Antibody - BSA Free" class="big_thumb lazy" loading="lazy" /> </a> </div></div><div id="ss_next0NB500-201" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-0NB500-201" class="cycle-circle-pager"></div><div id="image-caption0NB500-201"></div></div> </div> </div> <div class="flourish right"></div> <div class="prodDesc"><div><a href="/products/survivin-antibody_nb500-201#ReviewsSection"><div class="sprite_4Stars"></div></a> <a href="/products/survivin-antibody_nb500-201#ReviewsSection" class="bottom2"><span class="ctr">(22 Reviews)</span></a></div><div><a href="/products/survivin-antibody_nb500-201#PublicationSection"><div class="cnlp_publications"></div></a> <a 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class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NB500-201AF405"> <td><a href="/products/survivin-antibody_nb500-201af405">Alexa Fluor 405</a></td> <td><a href="/products/survivin-antibody_nb500-201af405">NB500-201AF405</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NB500-201AF488"> <td><a href="/products/survivin-antibody_nb500-201af488">Alexa Fluor 488</a></td> <td><a href="/products/survivin-antibody_nb500-201af488">NB500-201AF488</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NB500-201AF532"> <td><a href="/products/survivin-antibody_nb500-201af532">Alexa Fluor 532</a></td> <td><a 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href="/products/survivin-antibody_nb500-201af700">Alexa Fluor 700</a></td> <td><a href="/products/survivin-antibody_nb500-201af700">NB500-201AF700</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NB500-201AF750"> <td><a href="/products/survivin-antibody_nb500-201af750">Alexa Fluor 750</a></td> <td><a href="/products/survivin-antibody_nb500-201af750">NB500-201AF750</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NB500-201APC"> <td><a href="/products/survivin-antibody_nb500-201apc">Allophycocyanin</a></td> <td><a href="/products/survivin-antibody_nb500-201apc">NB500-201APC</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NB500-201B-0.1ml"> <td><a href="/products/survivin-antibody_nb500-201b">Biotin</a></td> <td><a href="/products/survivin-antibody_nb500-201b">NB500-201B-0.1ml</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NB500-201UV"> <td><a href="/products/survivin-antibody_nb500-201uv">DyLight 350</a></td> <td><a href="/products/survivin-antibody_nb500-201uv">NB500-201UV</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NB500-201V-0.1ml"> <td><a href="/products/survivin-antibody_nb500-201v">DyLight 405</a></td> <td><a href="/products/survivin-antibody_nb500-201v">NB500-201V-0.1ml</a></td> <td><div class="popup_stock"></div></td> <td><div 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<td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NB500-201C-0.1ml"> <td><a href="/products/survivin-antibody_nb500-201c">DyLight 650</a></td> <td><a href="/products/survivin-antibody_nb500-201c">NB500-201C-0.1ml</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NB500-201FR"> <td><a href="/products/survivin-antibody_nb500-201fr">DyLight 680</a></td> <td><a href="/products/survivin-antibody_nb500-201fr">NB500-201FR</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="NB500-201IR"> <td><a href="/products/survivin-antibody_nb500-201ir">DyLight 755</a></td> <td><a 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href="/products/survivin-antibody_nb500-201">NB500-201SS</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/182223"><div class="purchase_cart"></div></a></td> </tr> <tr class="scf_footer"> <td colspan="5"><div class="expander option_opened"></div></td> </tr> </tbody> </table> <div class="popup_skus" data-skus='["NB500-201SS"]' data-rendered="false"></div></div></div></div> <div class="cnlpProd"> <div class="cnlpProdTop"> <div class="prodBanner">  <div class="catalog_number"> <a class="ecommerce_link" data-id="AF886" data-brand="rnd" data-name="Survivin Antibody [Unconjugated]" data-position="2" href="/products/survivin-antibody_af886" title="Survivin Antibody [Unconjugated]">Survivin Antibody [Unconjugat ...</a> <div style="display:none;">Survivin Antibody [Unconjugated]</div> </div> </div> <div class="prodContainer"> <div class="flourish left"></div> <div class="prodImages"> <div>AF886</div> <div class="cnlpImages"><div class="images"><div id="ss_prev1AF886" class="cycle-pager"><div class="pager_left_on"></div></div><div class="cycle-slideshow slideshows" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-1AF886" data-cycle-prev="#ss_prev1AF886" data-cycle-next="#ss_next1AF886" data-cycle-caption="#image-caption1AF886" data-cycle-caption-template="Image {{slideNum}} of {{slideCount}}" data-cycle-slides=".big_thumb_container" ><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize2/Survivin_AF886_Western_Blot_5929.jpg" title="Western blot shows lysates of MCF-7 human breast cancer cell line and Jurkat human acute T cell leukemia cell line. PVDF membrane was probed with 0.5 µg/mL of Rabbit Anti-Human Survivin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF886) followed by HRP-conjugated Anti-Rabbit IgG Secondary Antibody (Catalog # HAF008). A specific band was detected for Survivin at approximately 19 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 4." class="big_lightbox" target="_blank"> <img src="//images.novusbio.com/images2/Survivin_AF886_Western_Blot_5929.jpg" alt="Western Blot Survivin Antibody [Unconjugated]" class="big_thumb" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize2/Survivin_AF886_Immunohistochemistry_20906.jpg" title=" Survivin was detected in immersion fixed paraffin-embedded sections of human breast cancer tissue using Rabbit Anti-Human Survivin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF886) at 3 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Rabbit IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC003). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasm. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents. " class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images2/Survivin_AF886_Immunohistochemistry_20906.jpg" alt="Immunohistochemistry Survivin Antibody [Unconjugated]" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize2/Survivin_AF886_Immunohistochemistry_6910.jpg" title="Survivin was detected in immersion fixed paraffin-embedded sections of human prostate cancer tissue using 10 µg/mL Rabbit Anti-Human Survivin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF886) overnight at 4 °C. Before incubation with the primary antibody tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013). Tissue was stained with the Anti-Rabbit HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS005) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images2/Survivin_AF886_Immunohistochemistry_6910.jpg" alt="Immunohistochemistry Survivin Antibody [Unconjugated]" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize2/16340.jpg" title="Simple Western lane view shows lysates of Jurkat human acute T cell leukemia cell line and MCF‑7 human breast cancer cell line, loaded at 0.2 mg/mL. A specific band was detected for Survivin at approximately 23 kDa (as indicated) using 5 µg/mL of Rabbit Anti-Human Survivin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF886). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images2/16340.jpg" alt="Simple Western Survivin Antibody [Unconjugated]" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/af886_human-survivin-affinity-purified-polyclonal-ab-822024950326.jpg" title="Survivin expression in human chondrosarcoma. Immunohistochemistry and immunoblot for survivin (red staining) from human chondrosarcoma specimens. A: Low-power image of human high-grade chondrosarcoma displays strong cellular expression of survivin protein. B: High-power magnification reveals the predominantly cytoplasmic staining, although strong nuclear signals are detectable. C and D: Other specimen of a grade III chondrosarcoma stained with monoclonal antibody, shows a similar pattern of staining. E: Strong survivin signal in a tumor cell displaying a mitotic figure (arrow). F: To verify the expression of survivin in human chondrosarcoma, immunoblots were performed from 3 high grade chondrosarcoma lysates (Patient Nr. 5, 7, 10). As control for the correct molecular weight, in vitro-transcribed and -translated (IVTT) recombinant survivin protein, derived from the full-length human cDNA was loaded. Furthermore, lysates from adult human cartilage served as a negative control. Total protein loaded was 1 μg for recombinant human survivin, 60 μg for chondrosarcoma and cartilage lysates. For A, B and E the polyclonal rabbit anti-survivin antibody AF886 was used. For C and D the monoclonal mouse anti-survivin antibody clone 32.1 was used. Original magnifications: 200× (A and C) and 400× (B and D) and 600× (E). Image collected and cropped by CiteAb from the following open publication (//bmccancer.biomedcentral.com/articles/10.1186/1471-2407-11-120), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/af886_human-survivin-affinity-purified-polyclonal-ab-822024950326.jpg" alt="Immunohistochemistry Survivin Antibody [Unconjugated]" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/af886_human-survivin-affinity-purified-polyclonal-ab-822024951147.jpg" title="Survivin is required for the proliferation of trophoblastic cells and depletion induces a G2/M arrest.(A) Cell viability assay. JAR (left panel), BeWo (middle panel) and HTR-8/SVneo (HTR, right panel) cells were non-treated (con), treated with either control scrambled siRNA (si con) or siRNA targeting survivin (si survivin) and cell viability was analyzed at indicated time points. Bar: ± SD. (B) Cell cycle profiles. Cells were depleted of survivin for 48 h and cell cycle analysis was performed. con: untreated cells as control. si con: treated with control scrambled siRNA. si survivin: treated with siRNA against survivin. Right panels: quantification of the sub-phases of the cell cycle. (C) Western blot analysis. BeWo cells were transfected with scrambled siRNA (si con) or siRNA targeting survivin (si survivin) for 24 h or 48 h and cellular extracts were prepared for Western blot analysis using indicated antibodies. beta -actin served as loading control. con: non-treated lysates as control. (D) Relative caspase-3/7 activity. The lysates from JAR or BeWo cells treated as in (C) were used for evaluating caspase-3/7 activity. The results are presented as mean ± SD. Image collected and cropped by CiteAb from the following open publication (//dx.plos.org/10.1371/journal.pone.0073337), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/af886_human-survivin-affinity-purified-polyclonal-ab-822024951147.jpg" alt="Western Blot Survivin Antibody [Unconjugated]" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/af886_human-survivin-affinity-purified-polyclonal-ab-822024950595.jpg" title="ATM and DNA-PKCS induce cell cycle arrest after Survivin-RNAi. a: Western blot analysis of HCT116 and HCT116shATM total cell lysates following Survivin-RNAi (shSurv). Included are shLuc-transduced cells as control. Red values indicate densitometric estimation of protein levels, normalized to Tubulin. b: Indirect immunofluorescence analysis of transduced SBC-2 cells showing colocalisation of activated ATM (ATM S1981) and activated DNA-PK kinase (DNA-PKCS T2609) in shSurv polyploid cells. c: Western blot of HCT116 and HCT116p53−/− cell lysates showing analysis of p53 phosphorylation sites after Survivin knockdown. d: Proposed outline of Survivin RNAi phenotype and the observed DNA-damage response signaling. e: Analysis of HCT116 and HCT116shATM cells transduced with shSurv and combined treatment with DNA-PKCS inhibitor (DNA-PK-I, 10 μM Nu7026) or DMSO. Note combined inhibition of ATM and DNA-PKcs results in a decreased accumulation of p53 and p21waf/cip protein levels and reduction of gamma H2AX levels. Image collected and cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/24886358), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/af886_human-survivin-affinity-purified-polyclonal-ab-822024950595.jpg" alt="Western Blot Survivin Antibody [Unconjugated]" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/af886_human-survivin-affinity-purified-polyclonal-ab-8220249511411.jpg" title="Survivin in tubulointerstitial cells.A, Western blot analysis of survivin protein in the renal cortex of wild type and Itga8-/- mice after induction of unilateral ureter obstruction (UUO). B,Exemplary photomicrographs show renal localization of survivin. Itga8+/+, wild type mice; Itga8-/-, Itga8-deficient mice. Data are means±SEM. # p<0.05 UUO versus control (co). Image collected and cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/26938996), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/af886_human-survivin-affinity-purified-polyclonal-ab-8220249511411.jpg" alt="Immunohistochemistry Survivin Antibody [Unconjugated]" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/af886_human-survivin-affinity-purified-polyclonal-ab-8220249505945.jpg" title="Inhibition of PI3K gamma attenuates tumor growth in xenograft models associated with infiltrated macrophages.a Experimental procedure illustrating the TG100-115 treatment regimen in BALB/c mice. b CT26 cells (5 × 105 cells/mouse) were subcutaneously injected into the flanks of 6-week-old mice. Mean tumor volume of subcutaneously implanted vehicle- or TG100-115-treated mice (n = 5) and representative images of subcutaneous tumors at day 16 after treatment with vehicle or TG100-115 (box) are shown. c FACS analysis and quantification of CD11b+ F4/80+ (TAM) cell populations in CT26 tumors at day 14 posttreatment (n = 5) and expression levels of MHCII (M1) and CD206 (M2) in CD11b+ F4/80+ cell populations. d Graph showing the percentage of each population (M1, M2) in the vehicle-treated group in comparison with the TG100-115-treated group. e mRNA expression levels of genes involved in the proinflammatory response (il-1 beta , cxcl10) and antiinflammatory response (il-10 and tgf-beta ) were evaluated by real-time PCR in vehicle and TG100-155-treated groups. f Representative western blot analysis showing survival/EMT-related protein expression as well as ERK/AKT-FBW7-MCL-1 signal axis regulation in vehicle- and TG100-155-treated mouse tumor tissues. Image collected and cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/32444799), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/af886_human-survivin-affinity-purified-polyclonal-ab-8220249505945.jpg" alt="Western Blot Survivin Antibody [Unconjugated]" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/af886_human-survivin-affinity-purified-polyclonal-ab-822024951287.jpg" title="Opposite effects of M1 and M2 macrophages on tumor growth.a Tumor images and b tumor growth 3 weeks after transplantation of HCT116 cells after long-term coculture with differentiated M0, M1, or M2 macrophages (see Materials and Methods). Tumor size was measured 2–3 times a week with a caliper. Tumor volume was calculated using the following formula: tumor volume = (short length × long length × width)/2. The expression of SURVIVIN or p21c) and proliferation markers d in mouse subcutaneous tissues was evaluated by real-time PCR and western blotting, respectively. e Ki67 staining (1:200) of mouse subcutaneous tissues three weeks after subcutaneous injection. Scale bar: 100 μm. The results shown are presented as the mean ± SD from three mice per group. Actin was used as a loading control. *P < 0.05; **P < 0.01; ***P < 0.001. Image collected and cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/32444799), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/af886_human-survivin-affinity-purified-polyclonal-ab-822024951287.jpg" alt="Western Blot Survivin Antibody [Unconjugated]" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/af886_human-survivin-affinity-purified-polyclonal-ab-8220249503299.jpg" title="Survivin in tubulointerstitial cells.A, Western blot analysis of survivin protein in the renal cortex of wild type and Itga8-/- mice after induction of unilateral ureter obstruction (UUO). B,Exemplary photomicrographs show renal localization of survivin. Itga8+/+, wild type mice; Itga8-/-, Itga8-deficient mice. Data are means±SEM. # p<0.05 UUO versus control (co). Image collected and cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/26938996), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/af886_human-survivin-affinity-purified-polyclonal-ab-8220249503299.jpg" alt="Western Blot Survivin Antibody [Unconjugated]" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/af886_human-survivin-affinity-purified-polyclonal-ab-8220249503298.jpg" title="Role of PI3K gamma in TAM-mediated colon cancer cell viability and EMT characteristics.mRNA expression levels of genes involved in the proinflammatory response (IL-1 alpha , IL-1 beta , CXCL10, and IL-8) and antiinflammatory response (IL-10 and CCL17) were evaluated by real-time PCR in M1 a and M2 b macrophages with or without treatment with 10 nm TG100-115 (PI3K gamma inhibitor) for 18 h. c HT29 cells were exposed to TG100-115-treated macrophage CM for 24 h. Cell viability was then measured by WST-1 assay. d Expression levels of apoptosis- and EMT-related markers in CM-treated HT29 cells. CMs were derived from TG100-115 (10 nm)-treated or untreated M0, M1, and M2 macrophages. HT29 cells e and PDCs f were incubated with TG100-115-treated macrophage CM for 24 h. Protein levels of MCL-1 and FBW7 were evaluated using western blotting. Actin was used as a loading control. The results are presented as the mean ± SE. *P < 0.05; **P < 0.01; ***P < 0.001. Image collected and cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/32444799), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/af886_human-survivin-affinity-purified-polyclonal-ab-8220249503298.jpg" alt="Western Blot Survivin Antibody [Unconjugated]" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/af886_human-survivin-affinity-purified-polyclonal-ab-8220249505962.jpg" title="Analysis for RNA-induced silencing complex cleavage products in treated tumors and immunoblot analysis for target protein complexes and death signals in primary tumors. (A) Total RNA was isolated from tumor tissue and used for 5′ ligation-mediated RACE to determine whether RNA-induced silencing complex (RISC)-mediated cleavage of the transcript occurred. The predicted RACE products are indicated to the right, the size (base pairs (bp)) of the DNA standards shown on the left, and the treatment administered indicated above the lanes. (B) Immunoblot analysis of MDA-MB-231 day 10 tumor lysates following intravenous treatments of 0.01 mg/kg TBG-siCDK11, TBG-siCK2, or TBG-siCON1 as indicated above the blots. The signals for three mice per group are shown and the proteins detected are indicated on the right side of the blots. Actin signal was used as the loading control. (C) The protein signals from all mice in each treatment group were quantitated by densitometry using ImageJ software (National Institutes of Health Bethesda, MD, USA). Data presented as mean ± standard error. *P <0.05, **P <0.01. CDK, cyclin-dependent kinase; CK2, casein kinase 2; si, small interfering; TBG, tenfibgen. Image collected and cropped by CiteAb from the following open publication (//breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-015-0524-0), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/af886_human-survivin-affinity-purified-polyclonal-ab-8220249505962.jpg" alt="Western Blot Survivin Antibody [Unconjugated]" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/af886_human-survivin-affinity-purified-polyclonal-ab-8220249512812.jpg" title="Survivin expression in human chondrosarcoma. Immunohistochemistry and immunoblot for survivin (red staining) from human chondrosarcoma specimens. A: Low-power image of human high-grade chondrosarcoma displays strong cellular expression of survivin protein. B: High-power magnification reveals the predominantly cytoplasmic staining, although strong nuclear signals are detectable. C and D: Other specimen of a grade III chondrosarcoma stained with monoclonal antibody, shows a similar pattern of staining. E: Strong survivin signal in a tumor cell displaying a mitotic figure (arrow). F: To verify the expression of survivin in human chondrosarcoma, immunoblots were performed from 3 high grade chondrosarcoma lysates (Patient Nr. 5, 7, 10). As control for the correct molecular weight, in vitro-transcribed and -translated (IVTT) recombinant survivin protein, derived from the full-length human cDNA was loaded. Furthermore, lysates from adult human cartilage served as a negative control. Total protein loaded was 1 μg for recombinant human survivin, 60 μg for chondrosarcoma and cartilage lysates. For A, B and E the polyclonal rabbit anti-survivin antibody AF886 was used. For C and D the monoclonal mouse anti-survivin antibody clone 32.1 was used. Original magnifications: 200× (A and C) and 400× (B and D) and 600× (E). Image collected and cropped by CiteAb from the following open publication (//bmccancer.biomedcentral.com/articles/10.1186/1471-2407-11-120), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/af886_human-survivin-affinity-purified-polyclonal-ab-8220249512812.jpg" alt="Immunohistochemistry Survivin Antibody [Unconjugated]" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/af886_human-survivin-affinity-purified-polyclonal-ab-822024950462.jpg" title="Ex vivo analysis of the role of macrophage CM in colon cancer patient-derived cells (PDCs).a Estimation of PDC viability after coculture with macrophage CM for 24 h using the WST-1 assay. Error bars are derived from three independent experiments. b Expression levels of apoptosis and EMT markers in macrophage CM-treated PDCs were measured by western blotting. c Wound-healing ability was evaluated by creating wounds on a confluent monolayer of PDCs using 1-Dish 35-mm-high culture inserts. d Activation of AKT and ERK and expression levels of MCL-1 and FBW7 assessed by western blotting. Actin was used as a loading control. The results are presented as the mean ± SE. **P < 0.01; ***P < 0.001. Image collected and cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/32444799), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/af886_human-survivin-affinity-purified-polyclonal-ab-822024950462.jpg" alt="Western Blot Survivin Antibody [Unconjugated]" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/af886_human-survivin-affinity-purified-polyclonal-ab-822024951148.jpg" title="Response over time to TBG-RNAi-CK2 treatment in PC3-LN4 xenograft tumors(A) Verification of nuclear and cytosol protein fractionation from tumor tissue is shown by comparative immunoblot analysis of CK2 alpha alpha ′, lamin A/C, ERp72, and actin. T1, T2, and T3 labels indicate different tumors. Antibody sourcing information is listed in Materials and Methods. (B) Immunoblot analysis of fractionated PC3-LN4 tumor lysates following intravenous treatments of 0.01 mg/kg TBG-RNAi-CK2 or TBG-RNAi-F7 as indicated above the blots. The signals for three mice per group are shown, the proteins detected are indicated on the right, and the cell fraction and size markers are indicated on the left. Actin signal was used as the loading control. T1, T2, and T3 labels indicate different tumors within each treatment group. Antibody sourcing information is listed in Materials and Methods. (C) The percentage of Ki-67-positive tumor cells was determined from Ki-67-stained tumor sections. The percentage of Ki-67-positive cells on each day was expressed relative to day 5 (setting day 5 as 100%) and is shown graphically for each treatment. Mean and standard deviation are shown. Sample sizes: n = 6 for all groups except n = 7 for TBG-RNAi-F7 day 7. Image collected and cropped by CiteAb from the following open publication (//www.oncotarget.com/lookup/doi/10.18632/oncotarget.11442), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/af886_human-survivin-affinity-purified-polyclonal-ab-822024951148.jpg" alt="Western Blot Survivin Antibody [Unconjugated]" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/af886_human-survivin-affinity-purified-polyclonal-ab-8220249505947.jpg" title="Immunoblot analyses following small interfering RNA-mediated downregulation of CDK11 and CK2 in breast cancer cells. Immunoblot analysis of MDA-MB-231 and SUM-149 cell lysates following small interfering RNA (siRNA) transfection. Transfected siRNAs are indicated above the blots, proteins detected are indicated on the right side of the blots. CDK11p110, cyclin L1 alpha , cyclin L2 alpha , and CK2 alpha alpha ′ beta lysates are 72 hours post transfection; caspase 3, Bcl-xL, and survivin lysates are 96 hours post transfection. Actin signal was used as the loading control. CDK, cyclin-dependent kinase; CK2, casein kinase 2. Image collected and cropped by CiteAb from the following open publication (//breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-015-0524-0), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/af886_human-survivin-affinity-purified-polyclonal-ab-8220249505947.jpg" alt="Western Blot Survivin Antibody [Unconjugated]" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/af886_human-survivin-affinity-purified-polyclonal-ab-44202415433117.jpg" title="Survivin expression in human chondrosarcoma. Immunohistochemistry and immunoblot for survivin (red staining) from human chondrosarcoma specimens. A: Low-power image of human high-grade chondrosarcoma displays strong cellular expression of survivin protein. B: High-power magnification reveals the predominantly cytoplasmic staining, although strong nuclear signals are detectable. C and D: Other specimen of a grade III chondrosarcoma stained with monoclonal antibody, shows a similar pattern of staining. E: Strong survivin signal in a tumor cell displaying a mitotic figure (arrow). F: To verify the expression of survivin in human chondrosarcoma, immunoblots were performed from 3 high grade chondrosarcoma lysates (Patient Nr. 5, 7, 10). As control for the correct molecular weight, in vitro-transcribed and -translated (IVTT) recombinant survivin protein, derived from the full-length human cDNA was loaded. Furthermore, lysates from adult human cartilage served as a negative control. Total protein loaded was 1 μg for recombinant human survivin, 60 μg for chondrosarcoma and cartilage lysates. For A, B and E the polyclonal rabbit anti-survivin antibody AF886 was used. For C and D the monoclonal mouse anti-survivin antibody clone 32.1 was used. Original magnifications: 200× (A and C) and 400× (B and D) and 600× (E). Image collected and cropped by CiteAb from the following open publication (//bmccancer.biomedcentral.com/articles/10.1186/1471-2407-11-120), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/af886_human-survivin-affinity-purified-polyclonal-ab-44202415433117.jpg" alt="Immunohistochemistry Survivin Antibody [Unconjugated]" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/af886_human-survivin-affinity-purified-polyclonal-ab-8120255485726.jpg" title="BV6 considerably reduces expression of IAP proteins. SW480, HT-29 and HCT-15 cells were plated in a 3D laminin-rich extracellular matrix and treated with 1 μM BV6 or DMSO control 4 h before irradiation with 4 Gy. At different time points, expression of indicated proteins was analyzed by Western blotting, while beta -actin served as loading control. Two independent experiments were performed with similar results Image collected and cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/26383618), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/af886_human-survivin-affinity-purified-polyclonal-ab-8120255485726.jpg" alt="Western Blot Survivin Antibody [Unconjugated]" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/af886_human-survivin-affinity-purified-polyclonal-ab-8120255561341.jpg" title="Effects of BA and irradiation on protein expression levels of glioma cells. BA treatment affects the cleavage of PARP, the expression of survivin and hypoxia-induced HIF-1 alpha protein levels in U251MG (left) and U343MG (right) cells. Cell lines were untreated (UT), treated with DMSO or with increasing doses of BA from 10, 20 or 25 μM under normoxic conditions (A, B) and untreated (UT), treated with DMSO or with doses of 10 or 15 μM BA plus irradiation at 15 Gy under hypoxic conditions (C, D). Actin served as an internal loading control. The Western blot shows one representative result out of three independent experiments. Image collected and cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/21906280), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/af886_human-survivin-affinity-purified-polyclonal-ab-8120255561341.jpg" alt="Western Blot Survivin Antibody [Unconjugated]" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/af886_human-survivin-affinity-purified-polyclonal-ab-8120255552823.jpg" title="IGF-I induces Survivin through a Smad dependent mechanism.(A) NRP-152 cells plated overnight in GM3 were treated at various times with LR3-IGF-I for up to 72 h, and cell lysates were analyzed for Western blot expression of Survivin, and P-Smads 2 and 3. (B) NRP-152 cells stably expressing sh-Smads 2, 3, and 2+3 or lentiviral sh-LacZ (control) were treated with 2 nM LR3-IGF-I or vehicle for 24 h prior to Western blot analysis for Survivin and Smads 2 and 3. (C) NRP-152 cells stably expressing sh-Smads 2+3 or lentiviral sh-LacZ (control) were treated with DMSO vehicle or 10 µM SB431542 for 2 h prior to treatment with 2 nM LR3-IGF-I or vehicle for 24 h, and changes in Survivin expression was assessed by Western blot analysis. (D) NRP-152 cells were treated with either 10 µM HTS466284 or 10 µM SB43152 for 2 h prior to treatment with 2 nM LR3-IGF-I or vehicle for 24 h, and changes in Survivin expression were assessed by Western blot analysis. (E,F) RWPE-1 and VCaP cells plated in GM3 were treated with LR3-IGF-I and the TGF-beta receptor kinase inhibitors HTS466284 (HTS) or TKDI for 24 h prior to lysing cells for Western blot analysis of Survivin expression. Results are representative of two to three separate experiments. Image collected and cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/23658701), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/af886_human-survivin-affinity-purified-polyclonal-ab-8120255552823.jpg" alt="Western Blot Survivin Antibody [Unconjugated]" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/af886_human-survivin-affinity-purified-polyclonal-ab-8120255541728.jpg" title="Western blot analyses following treatment of PC-3 cells with AHC compounds.Western blot analysis of cellular lysates prepared from PC-3 cells treated with 7-O-galloyl catechin (GC), catechin (C), catechin gallate (CG), methyl gallate (MG), or equal dilution of DMSO was performed. Treatments are indicated above the blots. The protein detected is indicated to the left of each blot, and the size of protein detected is indicated to the right of each blot. The quantitation of the data is shown in Supplementary Table 2. Cropped blots are shown. Full sized blots are included in Supplementary Fig. 3. All gels and blots were run under the same experimental conditions as described in Methods. Image collected and cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/26975752), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/af886_human-survivin-affinity-purified-polyclonal-ab-8120255541728.jpg" alt="Western Blot Survivin Antibody [Unconjugated]" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/af886_human-survivin-affinity-purified-polyclonal-ab-812025553470.jpg" title="Effects of BA and irradiation on protein expression levels of glioma cells. BA treatment affects the cleavage of PARP, the expression of survivin and hypoxia-induced HIF-1 alpha protein levels in U251MG (left) and U343MG (right) cells. Cell lines were untreated (UT), treated with DMSO or with increasing doses of BA from 10, 20 or 25 μM under normoxic conditions (A, B) and untreated (UT), treated with DMSO or with doses of 10 or 15 μM BA plus irradiation at 15 Gy under hypoxic conditions (C, D). Actin served as an internal loading control. The Western blot shows one representative result out of three independent experiments. Image collected and cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/21906280), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/af886_human-survivin-affinity-purified-polyclonal-ab-812025553470.jpg" alt="Western Blot Survivin Antibody [Unconjugated]" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/af886_human-survivin-affinity-purified-polyclonal-ab-8120255552880.jpg" title="Effects of BA and irradiation on protein expression levels of glioma cells. BA treatment affects the cleavage of PARP, the expression of survivin and hypoxia-induced HIF-1 alpha protein levels in U251MG (left) and U343MG (right) cells. Cell lines were untreated (UT), treated with DMSO or with increasing doses of BA from 10, 20 or 25 μM under normoxic conditions (A, B) and untreated (UT), treated with DMSO or with doses of 10 or 15 μM BA plus irradiation at 15 Gy under hypoxic conditions (C, D). Actin served as an internal loading control. The Western blot shows one representative result out of three independent experiments. Image collected and cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/21906280), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/af886_human-survivin-affinity-purified-polyclonal-ab-8120255552880.jpg" alt="Western Blot Survivin Antibody [Unconjugated]" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/af886_human-survivin-affinity-purified-polyclonal-ab-812025557245.jpg" title="Effects of BA and irradiation on protein expression levels of glioma cells. BA treatment affects the cleavage of PARP, the expression of survivin and hypoxia-induced HIF-1 alpha protein levels in U251MG (left) and U343MG (right) cells. Cell lines were untreated (UT), treated with DMSO or with increasing doses of BA from 10, 20 or 25 μM under normoxic conditions (A, B) and untreated (UT), treated with DMSO or with doses of 10 or 15 μM BA plus irradiation at 15 Gy under hypoxic conditions (C, D). Actin served as an internal loading control. The Western blot shows one representative result out of three independent experiments. Image collected and cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/21906280), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/af886_human-survivin-affinity-purified-polyclonal-ab-812025557245.jpg" alt="Western Blot Survivin Antibody [Unconjugated]" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/af886_human-survivin-affinity-purified-polyclonal-ab-8120255541733.jpg" title="Western blot analyses following treatment of MDA-MB-231 cells with AHC compounds.Western blot analysis of cellular lysates prepared from MDA-MB-231 cells treated with 2 concentrations each of catechin gallate (CG) and methyl gallate (MG), or dilution of DMSO representing the highest concentration was performed. Treatments are indicated above the blots. The protein detected is indicated to the left of each blot, and the size of protein detected is indicated to the right of each blot. The quantitation of the data is shown in Supplementary Table 3. Cropped blots are shown. Full sized blots are included in Supplementary Fig. 4. All gels and blots were run under the same experimental conditions as described in Methods. Image collected and cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/26975752), licensed under a CC-BY license. Not internally tested by R&D Systems." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/af886_human-survivin-affinity-purified-polyclonal-ab-8120255541733.jpg" alt="Western Blot Survivin Antibody [Unconjugated]" class="big_thumb lazy" loading="lazy" /> </a> </div></div><div id="ss_next1AF886" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-1AF886" class="cycle-circle-pager"></div><div id="image-caption1AF886"></div></div> </div> </div> <div class="flourish right"></div> <div class="prodDesc"><div><a href="/products/survivin-antibody_af886#ReviewsSection"><div class="sprite_5Stars"></div></a> <a href="/products/survivin-antibody_af886#ReviewsSection" class="bottom2"><span class="ctr">(2 Reviews)</span></a></div><div><a href="/products/survivin-antibody_af886#PublicationSection"><div class="cnlp_publications"></div></a> <a href="/products/survivin-antibody_af886#PublicationSection" class="bottom2"><span class="ctr">(99 Publications)</span></a></div><strong>Species: </strong>Hu<br /><strong>Applications: </strong>WB, Simple Western, IHC<br /><strong>Host: </strong>Rabbit Polyclonal </div> </div> </div><div class="option_buttons_block"><button class="options_button" data-type="formulations">Formulations</button><div class="formulations_wrapper" data-title="Survivin Antibody [Unconjugated]" data-catnum="AF886"><table class="scf_table"> <thead> <tr> <th>Formulation</th> <th>Catalog #</th> <th>Availability</th> <th>Price</th> <th> </th> </tr> </thead> <tbody><tr class="popup_sku" data-sku="AF886-SP"> <td><a href="/products/survivin-antibody_af886">Carrier Free</a></td> <td><a href="/products/survivin-antibody_af886">AF886-SP</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_price"></div></td> <td><a href="/commerce/add-to-cart/430553"><div class="purchase_cart"></div></a></td> </tr> <tr class="scf_footer"> <td colspan="5"><div class="expander option_opened"></div></td> </tr> </tbody> </table> <div class="popup_skus" data-skus='["AF886-SP"]' data-rendered="false"></div></div></div></div> <div class="cnlpProd"> <div class="cnlpProdTop"> <div class="prodBanner">  <div class="catalog_number"> <a class="ecommerce_link" data-id="NB500-238" data-brand="novus" data-name="Survivin Antibody (60.11) - BSA Free" data-position="3" href="/products/survivin-antibody-6011_nb500-238" title="Survivin Antibody (60.11) - BSA Free">Survivin Antibody (60.11) - B ...</a> <div style="display:none;">Survivin Antibody (60.11) - BSA Free</div> </div> </div> <div class="prodContainer"> <div class="flourish left"></div> <div class="prodImages"> <div>NB500-238</div> <div class="cnlpImages"><div class="images"><div id="ss_prev2NB500-238" class="cycle-pager"><div class="pager_left_on"></div></div><div class="cycle-slideshow slideshows" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-2NB500-238" data-cycle-prev="#ss_prev2NB500-238" data-cycle-next="#ss_next2NB500-238" data-cycle-caption="#image-caption2NB500-238" data-cycle-caption-template="Image {{slideNum}} of {{slideCount}}" data-cycle-slides=".big_thumb_container" ><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/Survivin-Antibody-60-11-Immunohistochemistry-NB500-238-img0019.jpg" title="Immunohistochemistry: Survivin Antibody (60.11) [NB500-238] - Low-power image of human high-grade chondrosarcoma displays strong cellular expression of survivin protein (A). High-power magnification reveals the predominantly cytoplasmic staining, although strong nuclear signals are detectable (B). Other specimen of a grade III chondrosarcoma stained with monoclonal antibody, shows a similar pattern of staining (C and D). For A and B the polyclonal rabbit anti-survivin antibody [AF886] was used. For C and D the monoclonal mouse Survivin Antibody (60.11) [NB500-238] was used. Image collected and cropped by CiteAb from the following publication (//bmccancer.biomedcentral.com/articles/10.1186/1471-2407-11-120), licensed under a CC-BY license." class="big_lightbox" target="_blank"> <img src="//images.novusbio.com/images/Survivin-Antibody-60-11-Immunohistochemistry-NB500-238-img0019.jpg" alt="Immunohistochemistry Survivin Antibody (60.11) - BSA Free" class="big_thumb" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/Survivin-Antibody-60-11-Flow-Intracellular-NB500-238-img0015.jpg" title="Flow (Intracellular): Survivin Antibody (60.11) [NB500-238] - An intracellular stain was performed on A549 cells with Survivin Antibody (60.11) [NB500-238] and a matched isotype control. Cells were fixed with 4% PFA and then permeablized with 0.1% saponin. Cells were incubated in an antibody dilution of 1 ug/mL for 30 minutes at room temperature, followed by mouse F(ab)2 IgG (H+L) APC-conjugated secondary antibody (F0101B, R&D Systems). Image using the Unpurified form of this antibody." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/Survivin-Antibody-60-11-Flow-Intracellular-NB500-238-img0015.jpg" alt="Flow (Intracellular) Survivin Antibody (60.11) - BSA Free" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/Survivin-Antibody-60-11-Western-Blot-NB500-238-img0006.jpg" title="Western Blot: Survivin Antibody (60.11) [NB500-238] - Survivin detection in 30ug of HeLa whole cell extract using [NB500-238] at 1ug/ml. Detected at predicted molecular weight of 16 kDa." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/Survivin-Antibody-60-11-Western-Blot-NB500-238-img0006.jpg" alt="Western Blot Survivin Antibody (60.11) - BSA Free" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/Survivin-Antibody-60-11-Knockdown-Validated-NB500-238-img0020.jpg" title="Western Blot: Survivin Antibody (60.11) [NB500-238] - Knockdown Validation of Survivin Antibody (60.11) [NB500-238]. Suppression of survivin expression by transfection of siRNA. RNA interference was performed in SW1353 and Hs 819.T, either for GFP as control or for survivin. A: A pronounced decrease of survivin protein levels was measured by immunoblotting in SW1353 and Hs819.T. Image collected and cropped by CiteAb from the following publication (//bmccancer.biomedcentral.com/articles/10.1186/1471-2407-11-120), licensed under a CC-BY license." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/Survivin-Antibody-60-11-Knockdown-Validated-NB500-238-img0020.jpg" alt="Western Blot Survivin Antibody (60.11) - BSA Free" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/Survivin-Antibody-60-11-Immunocytochemistry-Immunofluorescence-NB500-238-img0021.jpg" title="Immunocytochemistry/Immunofluorescence: Survivin Antibody (60.11) [NB500-238] - HeLa cells stained NB500-205 (Green) detected with DyLight Fluor 488 conjugated anti-mouse IgG secondary antibody. Nuclei are counterstained with Hoechst 33258 (Blue). Image using the Unpurified format of this antibody." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/Survivin-Antibody-60-11-Immunocytochemistry-Immunofluorescence-NB500-238-img0021.jpg" alt="Immunocytochemistry/ Immunofluorescence Survivin Antibody (60.11) - BSA Free" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/Survivin-Antibody-60-11-Immunohistochemistry-Paraffin-NB500-238-img0022.jpg" title="Immunohistochemistry-Paraffin: Survivin Antibody (60.11) [NB500-238] - Staining of ovary cancer. Image using the Unpurified format of this antibody." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/Survivin-Antibody-60-11-Immunohistochemistry-Paraffin-NB500-238-img0022.jpg" alt="Immunohistochemistry-Paraffin Survivin Antibody (60.11) - BSA Free" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/Survivin-Antibody-60-11-Flow-Cytometry-NB500-238-img0017.jpg" title="Flow Cytometry: Survivin Antibody (60.11) [NB500-238] - An intracellular stain was performed on U2OS cells with Survivin Antibody (60.11) [NB500-238AF700] (blue) and a matched isotype control (orange). Cells were fixed with 4% PFA and then permeabilized with 0.1% saponin. Cells were incubated in an antibody dilution of 5 ug/mL for 30 minutes at room temperature. Both antibodies were conjugated to Alexa Fluor 700." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/Survivin-Antibody-60-11-Flow-Cytometry-NB500-238-img0017.jpg" alt="Flow Cytometry Survivin Antibody (60.11) - BSA Free" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/Survivin-Antibody-60-11-Flow-Intracellular-NB500-238-img0014.jpg" title="Flow (Intracellular): Survivin Antibody (60.11) [NB500-238] - An intracellular stain was performed on Daudi cells with Survivin Antibody (60.11)[NB500-238] (blue) and a matched isotype control, Mouse IgG2a Kappa Light Chain Isotype Control (MG2a-53) [NB600-986] (orange). Cells were fixed with 4% PFA and then permeablized with 0.1% saponin. Cells were incubated in an antibody dilution of 1 ug/mL for 30 minutes at room temperature, followed by mouse F(ab)2 IgG (H+L) APC-conjugated secondary antibody (F0101B, R&D Systems)." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/Survivin-Antibody-60-11-Flow-Intracellular-NB500-238-img0014.jpg" alt="Flow (Intracellular) Survivin Antibody (60.11) - BSA Free" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/nb500-238_mouse-monoclonal-survivin-antibody-60-11-27122023128565.jpg" title="Binding of antibody (60.11) used in imaging flow cytometry to full-length survivin protein and to survivin vaccine peptide aa53-67/M57 and wild type peptide aa53-67" class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/nb500-238_mouse-monoclonal-survivin-antibody-60-11-27122023128565.jpg" alt="Western Blot Survivin Antibody (60.11) - BSA Free" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/antibody/nb500-238_mouse-monoclonal-survivin-antibody-60-11-flow-cytometry-752024122816..jpg" title="A431 human skin carcinoma cell line was stained with Mouse anti-Survivin (60.11) Protein-G purified Monoclonal Antibody conjugated to Alexa Fluor® 647 (Catalog # NB500-238AF647, blue histogram) or matched control antibody (orange histogram)." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/antibody/nb500-238_mouse-monoclonal-survivin-antibody-60-11-flow-cytometry-752024122816..jpg" alt="Flow Cytometry Survivin Antibody (60.11) - BSA Free" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/nb500-238_mouse-monoclonal-survivin-antibody-60-11-31020241539726.jpg" title="Western Blot: Survivin Antibody (60.11) - BSA Free [NB500-238] - Binding of antibody (60.11) used in imaging flow cytometry to full-length survivin protein & to survivin vaccine peptide aa53-67/M57 & wild type peptide aa53-67 Image collected & cropped by CiteAb from the following publication (//www.oncotarget.com/lookup/doi/10.18632/oncotarget.21773), licensed under a CC-BY license. Not internally tested by Novus Biologicals." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/nb500-238_mouse-monoclonal-survivin-antibody-60-11-31020241539726.jpg" alt="Western Blot Survivin Antibody (60.11) - BSA Free" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/nb500-238_mouse-monoclonal-survivin-antibody-60-11-310202416163762.jpg" title="Western Blot: Survivin Antibody (60.11) - BSA Free [NB500-238] - CD133+ cells are more resistant to chemotherapeutic agents. STA-ET-8.2 cells were FACS-sorted & CD133+ & CD133- fractions treated with increasing concentrations of (A) Doxorubicin (Doxo), (B) Etoposide (Etop), (C) Vincristine (Vinc) or (D) a combination of all three drugs at high (Doxo 10 μM; Etop 10 ug/ml; Vinc 100 ng/ml), medium (Doxo 2.5 μM; 20 Etop 2.5 ug/ml; Vinc 25 ng/ml) & low (Doxo 0.5 μM; Etop 0.5 ug/ml; Vinc5 ng/ml) concentrations. Viability was assessed by MTS assay after 96 hrs (*p < 0.05) & CD133+ cells displayed increased drug resistance. (E): CD133+ & CD133- TC-71 cells are equally sensitive to Doxo, Etop, & Vinc. (F): Western blot reveals no difference in apoptosis & drug resistance protein expression between unsorted & CD133-sorted STA-ET-8.2 cell fractions. Image collected & cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/20346143), licensed under a CC-BY license. Not internally tested by Novus Biologicals." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/nb500-238_mouse-monoclonal-survivin-antibody-60-11-310202416163762.jpg" alt="Western Blot Survivin Antibody (60.11) - BSA Free" class="big_thumb lazy" loading="lazy" /> </a> </div></div><div id="ss_next2NB500-238" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-2NB500-238" class="cycle-circle-pager"></div><div id="image-caption2NB500-238"></div></div> </div> </div> <div class="flourish right"></div> <div class="prodDesc"><div><a href="/products/survivin-antibody-6011_nb500-238#ReviewsSection"><div class="sprite_4Stars"></div></a> <a href="/products/survivin-antibody-6011_nb500-238#ReviewsSection" class="bottom2"><span class="ctr">(3 Reviews)</span></a></div><div><a href="/products/survivin-antibody-6011_nb500-238#PublicationSection"><div class="cnlp_publications"></div></a> <a 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class="text_center"> <a href="/products/survivin-antibody-6011_nb500-238" class="readMore">Read More</a> </div> </div></div> <div class="clear"></div> <div class="cnlpSeeAll"> <a href="/primary-antibodies/survivin"> <img src="//images.novusbio.com/design/seeAllCNLP.png" alt="See All Survivin Products"> <div>We have 28 Survivin Antibodies</div> </a> </div> </div> <div class="clear"></div><a id="prodAntibody+Packs"></a><div class="prodHeader">Antibody Packs</div> <div class="cnlpProds"> <div class="cnlpProd"> <div class="cnlpProdTop"> <div class="prodBanner">  <div class="catalog_number"> <a class="ecommerce_link" data-id="NB100-911" data-brand="" data-name="Survivin Antibody Pack" data-position="1" href="/products/survivin-antibody-pack_nb100-911" title="Survivin Antibody Pack">Survivin Antibody Pack</a> <div style="display:none;">Survivin Antibody Pack</div> </div> </div> <div class="prodContainer"> <div class="flourish left"></div> <div class="prodImages"> <div>NB100-911</div> <div class="cnlpImages"><div class="images"><div id="ss_prev0NB100-911" class="cycle-pager"><div class="pager_left_on"></div></div><div class="cycle-slideshow slideshows" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-0NB100-911" data-cycle-prev="#ss_prev0NB100-911" data-cycle-next="#ss_next0NB100-911" data-cycle-caption="#image-caption0NB100-911" data-cycle-caption-template="Image {{slideNum}} of {{slideCount}}" data-cycle-slides=".big_thumb_container" ><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/Survivin-Antibody-Pack-RNAscope-compatible-NB100-911-img0006.jpg" title="Dual RNAscope ISH-IHC: Survivin Antibody Pack [NB100-911] - Formalin-fixed paraffin-embedded tissue sections of human esophagus squamous cell carcinoma were probed for Survivin mRNA (ACD RNAScope Probe, [465361]; Fast Red chromogen, ACD [322360]). Adjacent tissue section was processed for immunohistochemistry using rabbit polyclonal [NB500-201] at 1.5ug/mL with overnight incubation at 4 degrees Celsius followed by incubation with anti-rabbit IgG VisUCyte HRP Polymer Antibody [VC003] and DAB chromogen (yellow-brown). Tissue was counterstained with hematoxylin (blue). Specific staining was localized to tumor cells." class="big_lightbox" target="_blank"> <img src="//images.novusbio.com/images/Survivin-Antibody-Pack-RNAscope-compatible-NB100-911-img0006.jpg" alt="Dual RNAscope ISH-IHC Survivin Antibody Pack" class="big_thumb" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/Survivin-Antibody-Pack-Knockdown-Validated-NB100-911-img0008.jpg" title="Immunocytochemistry/ Immunofluorescence: Survivin Antibody Pack [NB100-911] - Anti-tumor effects and functional evidence of sCA-survivin-siRNA in HCT116 and HT29 solid tumor models. Immunostaining of survivin in the tumor tissues on day 19 using [NB500-201]. Scale bar, 50 um. Image collected and cropped by CiteAb from the following publication (//dx.plos.org/10.1371/journal.pone.0116022) licensed under a CC-BY license." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/Survivin-Antibody-Pack-Knockdown-Validated-NB100-911-img0008.jpg" alt="Immunocytochemistry/ Immunofluorescence Survivin Antibody Pack" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/Survivin-Antibody-Pack-Knockdown-Validated-NB100-911-img0010.jpg" title="Western Blot: Survivin Antibody Pack [NB100-911] - Suppression of survivin expression by transfection of siRNA. RNA interference was performed in SW1353 and Hs 819.T, either for GFP as control or for survivin. A: A pronounced decrease of survivin protein levels was measured by immunoblotting in SW1353 and Hs819.T. Image collected and cropped by CiteAb from the following publication (//bmccancer.biomedcentral.com/articles/10.1186/1471-2407-11-120), licensed under a CC-BY license. Survivin Antibody (60.11) [NB500-238]" class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/Survivin-Antibody-Pack-Knockdown-Validated-NB100-911-img0010.jpg" alt="Western Blot Survivin Antibody Pack" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/Survivin-Antibody-Pack-Immunocytochemistry-Immunofluorescence-NB100-911-img0007.jpg" title="Immunocytochemistry/Immunofluorescence: Survivin Antibody Pack [NB100-911] - Analysis using the HRP conjugate of [NB500-201]. Staining of Telophase with accumulation of survivin in the midbodies of two daughter cells. Survivin detection using [NB500-201]." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/Survivin-Antibody-Pack-Immunocytochemistry-Immunofluorescence-NB100-911-img0007.jpg" alt="Immunocytochemistry/ Immunofluorescence Survivin Antibody Pack" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/Survivin-Antibody-Pack-Immunohistochemistry-NB100-911-img0005.jpg" title="Immunohistochemistry: Survivin Antibody Pack [NB100-911] - Low-power image of human high-grade chondrosarcoma displays strong cellular expression of survivin protein (A). High-power magnification reveals the predominantly cytoplasmic staining, although strong nuclear signals are detectable (B). Other specimen of a grade III chondrosarcoma stained with monoclonal antibody, shows a similar pattern of staining (C and D). For A and B the polyclonal rabbit anti-survivin antibody [AF886] was used. For C and D the monoclonal mouse Survivin Antibody (60.11) [NB500-238] was used. Image collected and cropped by CiteAb from the following publication (//bmccancer.biomedcentral.com/articles/10.1186/1471-2407-11-120), licensed under a CC-BY license." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/Survivin-Antibody-Pack-Immunohistochemistry-NB100-911-img0005.jpg" alt="Immunohistochemistry Survivin Antibody Pack" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/Survivin-Antibody-Pack-Immunohistochemistry-Paraffin-NB100-911-img0009.jpg" title="Immunohistochemistry-Paraffin: Survivin Antibody Pack [NB100-911] - Immunohistochemical staining of formalin-fixed paraffin-embedded human lung cancer tissue using Survivin Antibody (32.1) [NB500-237]." class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images/Survivin-Antibody-Pack-Immunohistochemistry-Paraffin-NB100-911-img0009.jpg" alt="Immunohistochemistry-Paraffin Survivin Antibody Pack" class="big_thumb lazy" loading="lazy" /> </a> </div></div><div id="ss_next0NB100-911" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-0NB100-911" class="cycle-circle-pager"></div><div id="image-caption0NB100-911"></div></div> </div> </div> <div class="flourish right"></div> <div class="prodDesc"><div><a href="/products/survivin-antibody-pack_nb100-911#PublicationSection"><div class="cnlp_publications"></div></a> <a href="/products/survivin-antibody-pack_nb100-911#PublicationSection" class="bottom2"><span class="ctr">(7 Publications)</span></a></div><strong>Species: </strong>Hu, Mu<br /><strong>Applications: </strong>WB, ELISA, Flow, ICC/IF, IHC<br /> </div> </div> </div><div class="option_buttons_block"></div></div><div class="clear"></div> <div class="cnlpReadMores"> <div class="cnlpProd"> <div class="text_center"> <a href="/products/survivin-antibody-pack_nb100-911" class="readMore">Read More</a> </div> </div></div> <div class="clear"></div> <div class="cnlpSeeAll"> <a href="/antibody-packs/survivin"> <img src="//images.novusbio.com/design/seeAllCNLP.png" alt="See All Survivin Products"> <div>We have 1 Survivin Antibody Pack</div> </a> </div> </div> <div class="clear"></div><a id="prodELISA+Kits"></a><div class="prodHeader">ELISA Kits</div> <div class="cnlpProds"> <div class="cnlpProd"> <div class="cnlpProdTop"> <div class="prodBanner">  <div class="catalog_number"> <a class="ecommerce_link" data-id="DYC647-2" data-brand="rnd" data-name="Human Total Survivin DuoSet IC ELI..." data-position="1" href="/products/human-total-survivin-duoset-ic-elisa-2-plate_dyc647-2" title="Human Total Survivin DuoSet IC ELI...">Human Total Survivin DuoSet I ...</a> <div style="display:none;">Human Total Survivin DuoSet IC ELI...</div> </div> </div> <div class="prodContainer"> <div class="flourish left"></div> <div class="prodImages"> <div>DYC647-2</div> <div class="cnlpImages"><div class="images"><div class="cycle-slideshow slideshows" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-0DYC647-2" data-cycle-prev="#ss_prev0DYC647-2" data-cycle-next="#ss_next0DYC647-2" data-cycle-caption="#image-caption0DYC647-2" data-cycle-caption-template="Image {{slideNum}} of {{slideCount}}" data-cycle-slides=".big_thumb_container" ><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize2/dyc647-2_human-total-survivin-duoset-ic-economy-pack-15-plate-elisa-169202091050.jpg" title="ELISA Survivin [Biotin]" class="big_lightbox" target="_blank"> <img src="//images.novusbio.com/images2/dyc647-2_human-total-survivin-duoset-ic-economy-pack-15-plate-elisa-169202091050.jpg" alt="ELISA Survivin [Biotin]" class="big_thumb" /> </a> </div></div></div> </div> </div> <div class="flourish right"></div> <div class="prodDesc"><div><a href="/products/human-total-survivin-duoset-ic-elisa-2-plate_dyc647-2#PublicationSection"><div class="cnlp_publications"></div></a> <a href="/products/human-total-survivin-duoset-ic-elisa-2-plate_dyc647-2#PublicationSection" class="bottom2"><span class="ctr">(12 Publications)</span></a></div><strong>Species: </strong>Hu<br /><strong>Applications: </strong>ELISA<br /> </div> </div> </div><div class="option_buttons_block"><button class="options_button" data-type="conjugates">Conjugates</button><div class="conjugates_wrapper" data-title="Human Total Survivin DuoSet IC ELISA, 2 Plate" data-catnum="DYC647-2"><table class="scf_table"> <thead> <tr> <th>Conjugate</th> <th>Catalog #</th> <th class="head_avail">Availability</th> <th>Size</th> <th class="col_price">Price</th> </tr> </thead> <tbody><tr class="popup_sku" data-sku="DYC647E"> <td><a href="/products/human-total-survivin-duoset-ic-elisa-2-plate_dyc647-2">Biotin</a></td> <td><a href="/products/human-total-survivin-duoset-ic-elisa-2-plate_dyc647-2">DYC647E</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="DYC647-5"> <td><a href="/products/human-total-survivin-duoset-ic-elisa-2-plate_dyc647-2">Biotin</a></td> <td><a href="/products/human-total-survivin-duoset-ic-elisa-2-plate_dyc647-2">DYC647-5</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr> <tr class="scf_footer"> <td colspan="5"><div class="expander option_opened"></div></td> </tr> </tbody> </table> <div class="popup_skus" data-skus='["DYC647E","DYC647-5"]' data-rendered="false"></div></div></div></div> <div class="cnlpProd"> <div class="cnlpProdTop"> <div class="prodBanner">  <div class="catalog_number"> <a class="ecommerce_link" data-id="DSV00" data-brand="rnd" data-name="Human Survivin Quantikine ELISA Kit" data-position="2" href="/products/human-survivin-quantikine-elisa-kit_dsv00" title="Human Survivin Quantikine ELISA Kit">Human Survivin Quantikine ELI ...</a> <div style="display:none;">Human Survivin Quantikine ELISA Kit</div> </div> </div> <div class="prodContainer"> <div class="flourish left"></div> <div class="prodImages"> <div>DSV00</div> <div class="cnlpImages"><div class="images"><div id="ss_prev1DSV00" class="cycle-pager"><div class="pager_left_on"></div></div><div class="cycle-slideshow slideshows" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-1DSV00" data-cycle-prev="#ss_prev1DSV00" data-cycle-next="#ss_next1DSV00" data-cycle-caption="#image-caption1DSV00" data-cycle-caption-template="Image {{slideNum}} of {{slideCount}}" data-cycle-slides=".big_thumb_container" ><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize2/DATA_Survivin_DSV00_ELISA_835.jpg" title="N/A Survivin [HRP]" class="big_lightbox" target="_blank"> <img src="//images.novusbio.com/images2/DATA_Survivin_DSV00_ELISA_835.jpg" alt="N/A Survivin [HRP]" class="big_thumb" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize2/DATA_Survivin_DSV00_ELISA_836.jpg" title="" class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images2/DATA_Survivin_DSV00_ELISA_836.jpg" alt="N/A Survivin [HRP]" class="big_thumb lazy" loading="lazy" /> </a> </div><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize2/Survivin_DSV00_ELISA_187.jpg" title="" class="big_lightbox" target="_blank"> <img data-original="//images.novusbio.com/images2/Survivin_DSV00_ELISA_187.jpg" alt="N/A Survivin [HRP]" class="big_thumb lazy" loading="lazy" /> </a> </div></div><div id="ss_next1DSV00" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-1DSV00" class="cycle-circle-pager"></div><div id="image-caption1DSV00"></div></div> </div> </div> <div class="flourish right"></div> <div class="prodDesc"><div><a href="/products/human-survivin-quantikine-elisa-kit_dsv00#PublicationSection"><div class="cnlp_publications"></div></a> <a href="/products/human-survivin-quantikine-elisa-kit_dsv00#PublicationSection" class="bottom2"><span class="ctr">(10 Publications)</span></a></div><strong>Species: </strong>Hu<br /><strong>Applications: </strong>ELISA<br /> </div> </div> </div><div class="option_buttons_block"></div></div><div class="clear"></div> <div class="cnlpReadMores"> <div class="cnlpProd"> <div class="text_center"> <a href="/products/human-total-survivin-duoset-ic-elisa-2-plate_dyc647-2" class="readMore">Read More</a> </div> </div> <div class="cnlpProd"> <div class="text_center"> <a href="/products/human-survivin-quantikine-elisa-kit_dsv00" class="readMore">Read More</a> </div> </div></div> <div class="clear"></div> <div class="cnlpSeeAll"> <a href="/elisa-kits/survivin"> <img src="//images.novusbio.com/design/seeAllCNLP.png" alt="See All Survivin Products"> <div>We have 2 Survivin ELISA Kits</div> </a> </div> </div> <div class="clear"></div><a id="prodLysates"></a><div class="prodHeader">Lysates</div> <div class="cnlpProds"> <div class="cnlpProd"> <div class="cnlpProdTop"> <div class="prodBanner">  <div class="catalog_number"> <a class="ecommerce_link" data-id="NBL1-07987" data-brand="novus" data-name="Survivin Overexpression Lysate" data-position="1" href="/products/survivin-lysate_nbl1-07987" title="Survivin Overexpression Lysate">Survivin Overexpression Lysat ...</a> <div style="display:none;">Survivin Overexpression Lysate</div> </div> </div> <div class="prodContainer"> <div class="flourish left"></div> <div class="prodImages"> <div>NBL1-07987</div> <div class="cnlpImages"><div class="images"><div class="cycle-slideshow slideshows" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-0NBL1-07987" data-cycle-prev="#ss_prev0NBL1-07987" data-cycle-next="#ss_next0NBL1-07987" data-cycle-caption="#image-caption0NBL1-07987" data-cycle-caption-template="Image {{slideNum}} of {{slideCount}}" data-cycle-slides=".big_thumb_container" ><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/Survivin-Overexpression-Lysate-Adult-Normal-Western-Blot-NBL1-07987-img0002.jpg" title="Western Blot: Survivin Overexpression Lysate [NBL1-07987] - Western blot validation with an anti-DDK antibody. Left: Empty vector transfected control cell lysate (HEK293 cell lysate); Right: Survivin Overexpression Lysate [NBL1-07987]." class="big_lightbox" target="_blank"> <img src="//images.novusbio.com/images/Survivin-Overexpression-Lysate-Adult-Normal-Western-Blot-NBL1-07987-img0002.jpg" alt="Western Blot Survivin Overexpression Lysate" class="big_thumb" /> </a> </div></div></div> </div> </div> <div class="flourish right"></div> <div class="prodDesc"><strong>Species: </strong>Hu<br /><strong>Applications: </strong>WB<br /> </div> </div> </div><div class="option_buttons_block"></div></div><div class="clear"></div> <div class="cnlpReadMores"> <div class="cnlpProd"> <div class="text_center"> <a href="/products/survivin-lysate_nbl1-07987" class="readMore">Read More</a> </div> </div></div> <div class="clear"></div> <div class="cnlpSeeAll"> <a href="/lysates/survivin"> <img src="//images.novusbio.com/design/seeAllCNLP.png" alt="See All Survivin Products"> <div>We have 1 Survivin Lysate</div> </a> </div> </div> <div class="clear"></div><a id="prodProteins"></a><div class="prodHeader">Proteins</div> <div class="cnlpProds"> <div class="cnlpProd"> <div class="cnlpProdTop"> <div class="prodBanner">  <div class="catalog_number"> <a class="ecommerce_link" data-id="WBC010B" data-brand="rnd" data-name="Recombinant Human Survivin Western..." data-position="1" href="/products/recombinant-human-survivin-western-blot-standard-protein_wbc010b" title="Recombinant Human Survivin Western...">Recombinant Human Survivin We ...</a> <div style="display:none;">Recombinant Human Survivin Western...</div> </div> </div> <div class="prodContainer"> <div class="flourish left"></div> <div class="prodImages"> <div>WBC010B</div> <div class="cnlpImages"><div class="images"><a href="/products/recombinant-human-survivin-western-blot-standard-protein_wbc010b" title="100 guarantee" alt="100 guarantee"><div class="dsSprite_guaranteeLarge"></div></a></div> </div> </div> <div class="flourish right"></div> <div class="prodDesc"><div><a href="/products/recombinant-human-survivin-western-blot-standard-protein_wbc010b#PublicationSection"><div class="cnlp_publications"></div></a> <a href="/products/recombinant-human-survivin-western-blot-standard-protein_wbc010b#PublicationSection" class="bottom2"><span class="ctr">(2 Publications)</span></a></div><strong>Species: </strong>Hu<br /><strong>Applications: </strong>WB<br /> </div> </div> </div><div class="option_buttons_block"></div></div> <div class="cnlpProd"> <div class="cnlpProdTop"> <div class="prodBanner">  <div class="catalog_number"> <a class="ecommerce_link" data-id="NB110-92717PEP" data-brand="novus" data-name="Survivin Antibody Blocking Peptide" data-position="2" href="/products/survivin-protein_nb110-92717pep" title="Survivin Antibody Blocking Peptide">Survivin Antibody Blocking Pe ...</a> <div style="display:none;">Survivin Antibody Blocking Peptide</div> </div> </div> <div class="prodContainer"> <div class="flourish left"></div> <div class="prodImages"> <div>NB110-92717PEP</div> <div class="cnlpImages"><div class="images"><a href="/products/survivin-protein_nb110-92717pep" title="100 guarantee" alt="100 guarantee"><div class="dsSprite_guaranteeLarge"></div></a></div> </div> </div> <div class="flourish right"></div> <div class="prodDesc"><strong>Species: </strong>Hu<br /><strong>Applications: </strong>AC<br /> </div> </div> </div><div class="option_buttons_block"></div></div> <div class="cnlpProd"> <div class="cnlpProdTop"> <div class="prodBanner">  <div class="catalog_number"> <a class="ecommerce_link" data-id="NBC1-18508" data-brand="novus" data-name="Recombinant Human Survivin (Calmod..." data-position="3" href="/products/survivin-recombinant-protein_nbc1-18508" title="Recombinant Human Survivin (Calmod...">Recombinant Human Survivin (C ...</a> <div style="display:none;">Recombinant Human Survivin (Calmod...</div> </div> </div> <div class="prodContainer"> <div class="flourish left"></div> <div class="prodImages"> <div>NBC1-18508</div> <div class="cnlpImages"><div class="images"><div class="cycle-slideshow slideshows" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-2NBC1-18508" data-cycle-prev="#ss_prev2NBC1-18508" data-cycle-next="#ss_next2NBC1-18508" data-cycle-caption="#image-caption2NBC1-18508" data-cycle-caption-template="Image {{slideNum}} of {{slideCount}}" data-cycle-slides=".big_thumb_container" ><div class="big_thumb_container"> <a href="//images.novusbio.com/fullsize/Recombinant-Human-Survivin-Calmodulin-Protein-SDS-Page-NBC1-18508-img0001.jpg" title="SDS-Page: Recombinant Human Survivin Calmodulin Protein [NBC1-18508] - 3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain." class="big_lightbox" target="_blank"> <img src="//images.novusbio.com/images/Recombinant-Human-Survivin-Calmodulin-Protein-SDS-Page-NBC1-18508-img0001.jpg" alt="SDS-PAGE Recombinant Human Survivin (Calmodulin Tag) Protein" class="big_thumb" /> </a> </div></div></div> </div> </div> <div class="flourish right"></div> <div class="prodDesc"><strong>Species: </strong>Hu<br /><strong>Applications: </strong>PAGE<br /> </div> </div> </div><div class="option_buttons_block"></div></div><div class="clear"></div> <div class="cnlpReadMores"> <div class="cnlpProd"> <div class="text_center"> <a href="/products/recombinant-human-survivin-western-blot-standard-protein_wbc010b" class="readMore">Read More</a> </div> </div> <div class="cnlpProd"> <div class="text_center"> <a href="/products/survivin-protein_nb110-92717pep" class="readMore">Read More</a> </div> </div> <div class="cnlpProd"> <div class="text_center"> <a href="/products/survivin-recombinant-protein_nbc1-18508" class="readMore">Read More</a> </div> </div></div> <div class="clear"></div> <div class="cnlpSeeAll"> <a href="/proteins/survivin"> <img src="//images.novusbio.com/design/seeAllCNLP.png" alt="See All Survivin Products"> <div>We have 4 Survivin Proteins</div> </a> </div> </div> <div class="clear"></div> </div></div> <div class="clear"></div><br /> <div class="grid_16"><h2 class="greyHead">Description</h2> Survivin (BIRC5 or IAP4) is the smallest member of the inhibitor of apoptosis (IAP) proteins, containing only a single baculovirus IAP repeat (BIR) domain and lacking the C-terminal RING domain. Survivin has a theoretical molecular weight of 16.5 kDa (wild-type protein) and exists as ten splice variant forms including the most predominant isoforms, survivin-2B and surviving-DeltaEx3 (1). It also undergoes phosphorylation by PKA, Plk1, Cdk1, CKII and Aurora B at multiple sites (e.g. Serine 20 and Threonine 34, 53 and 117). <br/><br/>Besides being highly abundant in fetal development and expressed in proliferating adult cells such as activated T lymphocytes, erythroblasts, and self-renewing stem cells, survivin is generally absent in adult tissues. However, it is elevated in common cancers such as lung, colon, pancreas, breast and prostate where it drives proliferation, metastasis, poor prognosis, and decreased patient survival (2). <br/><br/>Survivin has been shown to be involved in multiple cellular processes including cell cycle progression, mitotic spindle assembly, kinetochore attachment, angiogenesis, migration, and its anti-apoptotic activity has been linked to both its monomeric and homodimeric forms. Survivin impacts the function of other IAP members, c-IAP1 and c-IAP-2, or modulates the inhibitory activity of XIAP against caspases by forming a stable complex with XIAP and HBXIP. During the intrinsic apoptotic pathway, survivin may prevent the release of mitochondrial APAF1 into the cytoplasm or hinder the association of SMAC with other IAPS, which results in prolonged cell survival (3). <br/></br/>References<br/></br/> 1. Sah NK, Seniya C. (2015) Survivin splice variants and their diagnostic significance. Tumour Biol. 36(9):6623-31. PMID: 26245993 <br/><br/> 2. Lladser A, Sanhueza C, Kiessling R, Quest AF. (2011) Is survivin the potential Achilles' heel of cancer? Adv Cancer Res. 111:1-37. PMID: 21704829 <br/><br/> 3. Wheatley SP, Altieri DC. (2019) Survivin at a glance. J Cell Sci. 132(7). PMID: 30948431 <br/><br/><br /><br /><h2 class="greyHead">Bioinformatics</h2> <table class="wide cnlp_list"><tr> <td>Entrez</td> <td><div class="cnlp_list_pad"><a target="_blank" href="//www.ncbi.nlm.nih.gov/gene?term=11799"><div class="sprite_newWindow"></div> 11799</a></div>Mouse<br /><div class="cnlp_list_pad"><a target="_blank" href="//www.ncbi.nlm.nih.gov/gene?term=332"><div class="sprite_newWindow"></div> 332</a></div>Human<br /><div class="cnlp_list_pad"><a target="_blank" href="//www.ncbi.nlm.nih.gov/gene?term=442936"><div class="sprite_newWindow"></div> 442936</a></div>Canine<br /><div class="cnlp_list_pad"><a target="_blank" href="//www.ncbi.nlm.nih.gov/gene?term=493835"><div class="sprite_newWindow"></div> 493835</a></div>Feline<br /><div class="cnlp_list_pad"><a target="_blank" href="//www.ncbi.nlm.nih.gov/gene?term=64041"><div class="sprite_newWindow"></div> 64041</a></div>Rat<br /> </td> </tr><tr> <td>Uniprot</td> <td><div class="cnlp_list_pad"><a target="_blank" href="http://www.uniprot.org/uniprot/?query=AAH08718"><div class="sprite_newWindow"></div> AAH08718</a></div>Human<br /><div class="cnlp_list_pad"><a target="_blank" href="http://www.uniprot.org/uniprot/?query=AAH08718.1"><div class="sprite_newWindow"></div> AAH08718.1</a></div>Human<br /><div class="cnlp_list_pad"><a target="_blank" href="http://www.uniprot.org/uniprot/?query=NP_001012271.1"><div class="sprite_newWindow"></div> NP_001012271.1</a></div>Human<br /><div class="cnlp_list_pad"><a target="_blank" href="http://www.uniprot.org/uniprot/?query=NP_001159"><div class="sprite_newWindow"></div> NP_001159</a></div>Human<br /><div class="cnlp_list_pad"><a target="_blank" href="http://www.uniprot.org/uniprot/?query=NP_001159.2"><div class="sprite_newWindow"></div> NP_001159.2</a></div>Human<br /><div class="cnlp_list_pad"><a target="_blank" href="http://www.uniprot.org/uniprot/?query=NP_001159.2"><div class="sprite_newWindow"></div> NP_001159.2</a></div>Human<br /><div class="cnlp_list_pad"><a target="_blank" href="http://www.uniprot.org/uniprot/?query=O15392"><div class="sprite_newWindow"></div> O15392</a></div>Human<br /><div class="cnlp_list_pad"><a target="_blank" href="http://www.uniprot.org/uniprot/?query=Q9JHY7"><div class="sprite_newWindow"></div> Q9JHY7</a></div>Rat<br /> </td> </tr><tr> <td>Product By Gene ID</td> <td><a href="/gene-id/332">332</a></td> </tr><tr> <td>Alternate Names</td> <td> <ul class="tightList"><li>API4</li><li>apoptosis inhibitor 4</li><li>Apoptosis inhibitor survivin</li><li>baculoviral IAP repeat-containing 5</li><li>Baculoviral IAP Repeat-Containing Protein 5</li><li>BIRC5</li><li>EPR-1</li><li>IAP4</li><li>survivin variant 3 alpha</li> </ul> </td> </tr></table><br /></div> <div class="clear"></div><div class="grid_8"> <h2 class="greyHead">Research Areas for Survivin</h2> Find related products by research area and learn more about each of the different research areas below.<br /><br /><a href="/research-areas/cancer/angiogenesis.html">Angiogenesis</a><br /><a href="/research-areas/apoptosis.html">Apoptosis</a><br /><a href="/research-areas/node/28991.html">Astrocyte Markers</a><br /><a href="/research-areas/cancer.html">Cancer</a><br /><a href="/research-areas/cellular-markers.html">Cellular Markers</a><br /><a href="/research-areas/stem-cell-markers/core-esc-like-genes.html">Core ESC-Like Genes</a><br /><a href="/research-areas/node/28991.html">Glia Markers</a><br /><a href="/research-areas/neuroscience/growth-and-development.html">Growth and Development</a><br /><a href="/research-areas/cancer/mitotic-regulators.html">Mitotic Regulators</a><br /><a href="/research-areas/neuroscience/neurodegeneration.html">Neurodegeneration</a><br /><a href="/research-areas/neuroscience/neuroscience-cell-identity-markers.html">Neuronal Cell Markers</a><br /><a href="/research-areas/neuroscience.html">Neuroscience</a><br /><a href="/research-areas/phospho-specific.html">Phospho-Specific</a><br /><a href="/research-areas/stem-cell-markers.html">Stem Cell Markers</a><br /><a href="/research-areas/cancer/tumor-suppressors.html">Tumor Suppressors</a><br /><br /></div> <div class="clear"></div> <div class="grid_16"><h2 class="greyHead">Related Survivin Blog Posts</h2> Check out the latest blog posts on Survivin. <table class="cnlp_lined wide"> <tbody><tr class="blog-section"> <td><a href="/antibody-news/antibodies/pcna-proliferating-cell-nuclear-antigen-polymerase-delta-auxiliary-protein">PCNA (Proliferating cell nuclear antigen, polymerase delta auxiliary protein)</a><br/> <span>PCNA is a nuclear protein essential for DNA replication as well as DNA excision and mismatch repair pathways. It coordinates the recruitment and association of needed components during both of these processes, both of which are essential for cell cycl...    <a href="/antibody-news/antibodies/pcna-proliferating-cell-nuclear-antigen-polymerase-delta-auxiliary-protein">Read more.</a></span> </td> </tr><tr class="blog-section"> <td><a href="/antibody-news/antibodies/survivin-acetylation-affecting-apoptosis-and-cancer">Survivin Acetylation: Affecting Apoptosis and Cancer</a><br/> <span>Survivin (BRIC5) is an inhibitor of apoptosis that also promotes cellular adaptation under stressful conditions and helps to regulate cell division. Recently, an antibody study by Dr. H Wang et al. at Brown University [PMID: 20826784] found that Survi...    <a href="/antibody-news/antibodies/survivin-acetylation-affecting-apoptosis-and-cancer">Read more.</a></span> </td> </tr><tr class="blog-section"> <td><a href="/antibody-news/antibodies/survivin-antibody-assays-using-sandwich-elisa-kits">Survivin Sandwich ELISA: There's a Kit for That</a><br/> <span>The Survivin antibody is widely used in apoptosis studies, and as a cellular marker. Today, biochemists have a wide range of Survivin antibody products to choose from, suitable for use in Western Blot, Chromatin Immunoprecipitation (ChIP), Immunofluor...    <a href="/antibody-news/antibodies/survivin-antibody-assays-using-sandwich-elisa-kits">Read more.</a></span> </td> </tr><tr class="blog-section"> <td><a href="/antibody-news/antibodies/trkb-docking-for-neurotrophins-and-beyond">TrkB: Docking for Neurotrophins and Beyond.</a><br/> <span>Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. TrK's are activated by several neurotrophins, which are small pro...    <a href="/antibody-news/antibodies/trkb-docking-for-neurotrophins-and-beyond">Read more.</a></span> </td> </tr><tr class="blog-section"> <td><a href="/antibody-news/antibodies/pcna-antibodies-marking-cell-proliferation-dna-replication">PCNA Antibodies: Marking Cell Proliferation & DNA Replication</a><br/> <span>Proliferating Cell Nuclear Antigen (PCNA), also known as the polymerase delta auxiliary protein, is a nuclear protein essential for DNA replication as well as DNA excision and mismatch repair pathways. It has a large role in cell cycle regulation and ...    <a href="/antibody-news/antibodies/pcna-antibodies-marking-cell-proliferation-dna-replication">Read more.</a></span> </td> </tr><tr class="blog-section"> <td><a href="/antibody-news/antibodies/caspase-7-the-cells-suicide-switch">Caspase 7: The Cell's Suicide Switch</a><br/> <span>Caspase 7 (also known as CASP7, Mch3, ICE-LAP3, CMH-1) is a member of caspase family of cysteine proteases. It is an apoptosis-related cystein peptidase encoded by the CASP7 gene in humans. CASP7 homologous sequences have been identified in nearly all...    <a href="/antibody-news/antibodies/caspase-7-the-cells-suicide-switch">Read more.</a></span> </td> </tr><tr class="blog-section"> <td><a href="/antibody-news/antibodies/trkb-bridging-ontogenesis-and-oncogenesis">TrkB: Bridging Ontogenesis and Oncogenesis</a><br/> <span>Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. Interaction of brain-derived neurotrophic factor (BDNF) with its ...    <a href="/antibody-news/antibodies/trkb-bridging-ontogenesis-and-oncogenesis">Read more.</a></span> </td> </tr><tr class="blog-section"> <td><a href="/antibody-news/antibodies/survivin-infographic">Survivin: Infographic</a><br/> <span>Survivin is involved in promoting cell proliferation and is an inhibitor of apoptosis. Survivin has a critical role in cancer proliferation and neural development. It may have an impact on neural cell proliferative responses following brain injury.L...    <a href="/antibody-news/antibodies/survivin-infographic">Read more.</a></span> </td> </tr><tr class="blog-section"> <td><a href="/antibody-news/antibodies/survivin-as-long-as-i-know-how-to-live-i-know-i-will">Survivin: As long as I know how to live I know I will</a><br/> <span>Survivin is an anti-apoptotic protein from a large family with related members such as X-linked IAP, cIAP1 and cIAP2, IAP-like protein-2, melanoma IAP, Livin, and NAIP. Survivin regulates fundamental physiological events including the cell cycle, feta...    <a href="/antibody-news/antibodies/survivin-as-long-as-i-know-how-to-live-i-know-i-will">Read more.</a></span> </td> </tr><tr class="blog-section"> <td><a href="/antibody-news/antibodies/livin-on-a-prayer">Livin: On a Prayer</a><br/> <span>Livin is a member of the inhibitor of apoptosis proteins (IAP) family that regulates programmed cell death. The Livin protein contains a single baculovirus IAP repeat (BIR) essential for function, along with a COOH-terminal RING-type zinc finger domai...    <a href="/antibody-news/antibodies/livin-on-a-prayer">Read more.</a></span> </td> </tr><tr class="blog-section"> <td><a href="/antibody-news/antibodies/survivin-is-thrivin">Survivin is thrivin'</a><br/> <span>The survivin anti-apoptotic protein is the smallest member of a large family of proteins such as X-linked IAP, c-IAP1 and 2, IAP-like protein-2, melanoma IAP, Livin, and NAIP. Survivin regulates basic physiological events such as the cell cycle, tumor...    <a href="/antibody-news/antibodies/survivin-is-thrivin">Read more.</a></span> </td> </tr><tr class="blog-section"> <td><a href="/antibody-news/the-ins-and-outs-of-survivin">The Ins and Outs of Survivin</a><br/> <span> By Rachel M.A. Linger, Ph.D.What is survivin?Survivin is a small (16.5 kDa) protein normally found in human fetal tissue. In contrast, survivin is typically undetectable in most normal adult tissues. Expression of ...    <a href="/antibody-news/the-ins-and-outs-of-survivin">Read more.</a></span> </td> </tr><tr class="blog-section"> <td><a href="/antibody-news/antibodies/cytochrome-c–a-mediator-of-apoptosis">Cytochrome C - a mediator of apoptosis </a><br/> <span>Cytochrome C is a small heme protein within the inner mitochondrial membrane responsible for carrying electrons within the respiratory transport chain. Additionally, cytochrome c has also been identified as a player in programmed cell death (apop...    <a href="/antibody-news/antibodies/cytochrome-c–a-mediator-of-apoptosis">Read more.</a></span> </td> </tr><tr class="blog-section"> <td><a href="/antibody-news/antibodies/survivin-an-inhibitor-of-apoptosis-protein">Survivin - an inhibitor of apoptosis protein</a><br/> <span>Survivin is an anti-apoptotic protein which is the smallest protein within a large family of proteins including X-linked IAP, c-IAP1 and 2, IAP-like protein-2, melanoma IAP, NAIP, and Livin. Survivin is responsible for a wide range of basic cellula...    <a href="/antibody-news/antibodies/survivin-an-inhibitor-of-apoptosis-protein">Read more.</a></span> </td> </tr><tr class="blog-section"> <td><a href=""></a><br/> <span>    <a href="">Read more.</a></span> </td> </tr><tr class="blog-section"> <td><a href="/antibody-news/antibodies/survivin-an-inhibitor-of-apoptosis-that-drives-tumorigenesis-and-metastasis">Survivin - an inhibitor of apoptosis that drives tumorigenesis and metastasis</a><br/> <span>Apoptosis is the tightly regulated process of programmed cell death. It plays an important role in normal physiologic development but has also been implicated in a number of diseases. Apoptosis is constantly downregulated by a family of anti-apop...    <a href="/antibody-news/antibodies/survivin-an-inhibitor-of-apoptosis-that-drives-tumorigenesis-and-metastasis">Read more.</a></span> </td> </tr></tbody> </table> <a href="/antibody-news/tag/survivin">Read more Survivin related blogs.</a><br /><br /> </div> </div> </div> <div id="block-block-21" class="block block-block"> <div class="content">  <div class="embeddedServiceInvitation" id="snapins_invite" aria-live="assertive" role="dialog" aria-atomic="true" style="display: none;"> <div class="embeddedServiceInvitationHeader" aria-labelledby="snapins_titletext" aria-describedby="snapins_bodytext"> <img id="embeddedServiceAvatar" /> <span class="embeddedServiceTitleText" id="snapins_titletext">Need help?</span> <button type="button" id="closeInvite" class="embeddedServiceCloseIcon" aria-label="Exit invitation">×</button> </div> <div class="embeddedServiceInvitationBody"> <p id="snapins_bodytext">How can we help you?</p> </div> <div class="embeddedServiceInvitationFooter" aria-describedby="snapins_bodytext"> <button type="button" class="embeddedServiceActionButton" id="rejectInvite">Close</button> <button type="button" class="embeddedServiceActionButton" id="acceptInvite">Start Chat</button> </div> </div> </div> </div> </div> </div> </div> <div id="novus_footer_line"></div>  </div> <div class="container_16"> <div id="footer"> <div class="grid_16 text_center"> <div class="fp_horzline"></div> </div> <div class="clear"></div> <div class="grid_16"> <table class="footer_boxes"> <tr> <th>Popular Products</th> <th>Company Information</th> <th>Support</th> <th>Stay Connected</th> </tr> <tr> <td> <ul class='links'><li><a href="/productsearch/novus">Antibodies</a></li><li><a href="/product-type/secondary-antibodies">Secondary Antibodies</a></li><li><a href="/product-type/isotype-controls">Isotype Controls</a></li><li><a href="/product-type/peptides-and-proteins">Proteins and Peptides</a></li><li><a href="/product-type/elisa-kits">ELISA Kits</a></li><li><a href="/samplesize">Sample Size</a></li><li><a href="https://www.novusbio.com/new-product-information-page.html">New Products</a></li> </ul> </td> <td> <ul class='links'><li><a href="/about.html">About Us</a></li><li><a href="https://www.bio-techne.com/about/careers">Careers</a></li><li><a href="/guarantee">Novus Guarantee</a></li><li><a href="/about/contact-us.html">Contact Us</a></li><li><a href="/about/novus-team.html">Our Team</a></li> </ul> </td> <td> <ul class='links'><li><a href="/support/technical-support.html">Technical Support</a></li><li><a href="/support/faqs.html">FAQs</a></li><li><a href="/webform/help-finding-antibodies">Help Finding Antibodies</a></li><li><a href="/support/support-by-application.html">Protocols</a></li> </ul> </td> <td id="footer_social_links"> </td> </tr> </table> </div> <div class="clear"></div> <div class="grid_16"> <div id="GTS_CONTAINER" style="float: right;margin-top: 10px;"></div> <div id="footer_officeinfo"> </div> <div class="fp_horzline"></div> <div class="footer_othersites"> <p>Visit our other sites</p> <a href="https://www.bio-techne.com/" target="_blank"><div class="fp_biotechne"></div></a> <a href="https://www.rndsystems.com/"><div class="fp_rnd"></div></a> <a href="https://www.novusbio.com/" target="_blank"><div class="fp_novus"></div></a> <a href="https://www.tocris.com/" target="_blank"><div class="fp_tocris"></div></a> <a href="https://www.bio-techne.com/brands/proteinsimple" target="_blank"><div class="fp_proteinSimple"></div></a> <a href="http://www.biospacific.com/" target="_blank"><div class="fp_biospacific"></div></a>  <a href="http://www.acdbio.com/" target="_blank"><div class="fp_acd"></div></a> <a href="https://www.rndheme.com/" target="_blank"><div class="fp_rndcc"></div></a> </div> <div class="text_center"> <div class="fp_horzline"></div> </div> <div class="copyright">©2025 Novus Biologicals, All Rights Reserved.</div> <div class="footer_legal"> <ul class="links"><li class="menu-47946 first"><a href="/support/customer-service/privacy-policy.html" title="">Privacy Policy</a></li> <li class="menu-47956"><a href="/novus-bio-sitemap.html" title="">Sitemap</a></li> <li class="menu-47951"><a href="/about/contact-us.html" title="">Contact Us</a></li> <li class="menu-47941 last"><a href="/support/customer-service/terms.html" title="">Terms & Conditions</a></li> </ul> </div> <div class="clear"></div> </div> </div> </div> <script type="text/javascript"> <![CDATA[//><!]]> </script> <script type="text/javascript">window.NREUM||(NREUM={});NREUM.info={"beacon":"bam.nr-data.net","licenseKey":"76fb58fb05","applicationID":"788348554,30870807","transactionName":"YFdbZBFZXxdWAhAMVlkdeFMXUV4KGAYBC1xFU01VPFtfCEc=","queueTime":19,"applicationTime":874,"atts":"TBBYEllDTBk=","errorBeacon":"bam.nr-data.net","agent":""}</script></body> </html>

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