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class="vector-dropdown-label-text">個人用ツール</span> </label> <div class="vector-dropdown-content"> <div id="p-personal" class="vector-menu mw-portlet mw-portlet-personal user-links-collapsible-item" title="利用者メニュー" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-sitesupport" class="user-links-collapsible-item mw-list-item"><a href="https://donate.wikimedia.org/?wmf_source=donate&wmf_medium=sidebar&wmf_campaign=ja.wikipedia.org&uselang=ja"><span>寄付</span></a></li><li id="pt-createaccount" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=%E7%89%B9%E5%88%A5:%E3%82%A2%E3%82%AB%E3%82%A6%E3%83%B3%E3%83%88%E4%BD%9C%E6%88%90&returnto=%E3%82%A2%E3%82%B7%E3%83%93%E3%82%B7%E3%83%B3" title="アカウントを作成してログインすることをお勧めしますが、必須ではありません"><span class="vector-icon mw-ui-icon-userAdd mw-ui-icon-wikimedia-userAdd"></span> <span>アカウント作成</span></a></li><li id="pt-login" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=%E7%89%B9%E5%88%A5:%E3%83%AD%E3%82%B0%E3%82%A4%E3%83%B3&returnto=%E3%82%A2%E3%82%B7%E3%83%93%E3%82%B7%E3%83%B3" title="ログインすることを推奨します。ただし、必須ではありません。 [o]" accesskey="o"><span class="vector-icon mw-ui-icon-logIn mw-ui-icon-wikimedia-logIn"></span> <span>ログイン</span></a></li> </ul> </div> </div> <div id="p-user-menu-anon-editor" class="vector-menu mw-portlet mw-portlet-user-menu-anon-editor" > <div class="vector-menu-heading"> ログアウトした編集者のページ <a href="/wiki/Wikipedia:%E3%82%A6%E3%82%A3%E3%82%AD%E3%83%9A%E3%83%87%E3%82%A3%E3%82%A2%E3%81%B8%E3%82%88%E3%81%86%E3%81%93%E3%81%9D" aria-label="編集の詳細"><span>もっと詳しく</span></a> </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-anoncontribs" class="mw-list-item"><a href="/wiki/%E7%89%B9%E5%88%A5:%E8%87%AA%E5%88%86%E3%81%AE%E6%8A%95%E7%A8%BF%E8%A8%98%E9%8C%B2" title="このIPアドレスからなされた編集の一覧 [y]" accesskey="y"><span>投稿記録</span></a></li><li id="pt-anontalk" class="mw-list-item"><a href="/wiki/%E7%89%B9%E5%88%A5:%E3%83%88%E3%83%BC%E3%82%AF%E3%83%9A%E3%83%BC%E3%82%B8" title="このIPアドレスからなされた編集についての議論 [n]" accesskey="n"><span>トーク</span></a></li> </ul> </div> </div> </div> </div> </nav> </div> </header> </div> <div class="mw-page-container"> <div class="mw-page-container-inner"> <div class="vector-sitenotice-container"> <div id="siteNotice"></div> </div> <div class="vector-column-start"> <div class="vector-main-menu-container"> <div id="mw-navigation"> <nav id="mw-panel" class="vector-main-menu-landmark" aria-label="サイト"> <div id="vector-main-menu-pinned-container" class="vector-pinned-container"> </div> </nav> </div> </div> <div class="vector-sticky-pinned-container"> <nav id="mw-panel-toc" aria-label="目次" data-event-name="ui.sidebar-toc" class="mw-table-of-contents-container vector-toc-landmark"> <div id="vector-toc-pinned-container" class="vector-pinned-container"> <div id="vector-toc" class="vector-toc vector-pinnable-element"> <div class="vector-pinnable-header vector-toc-pinnable-header vector-pinnable-header-pinned" data-feature-name="toc-pinned" data-pinnable-element-id="vector-toc" > <h2 class="vector-pinnable-header-label">目次</h2> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-toc.pin">サイドバーに移動</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-toc.unpin">非表示</button> </div> <ul class="vector-toc-contents" id="mw-panel-toc-list"> <li id="toc-mw-content-text" class="vector-toc-list-item vector-toc-level-1"> <a href="#" class="vector-toc-link"> <div class="vector-toc-text">ページ先頭</div> </a> </li> <li id="toc-研究" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#研究"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>研究</span> </div> </a> <ul id="toc-研究-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-出典" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#出典"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>出典</span> </div> </a> <ul id="toc-出典-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-外部リンク" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#外部リンク"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>外部リンク</span> </div> </a> <ul id="toc-外部リンク-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="目次" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="目次の表示・非表示を切り替え" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">目次の表示・非表示を切り替え</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">アシビシン</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="特定の記事の別の言語版に移動します。利用可能な言語6件" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-6" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">6の言語版</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-azb mw-list-item"><a href="https://azb.wikipedia.org/wiki/%D8%A7%D8%B3%DB%8C%D9%88%DB%8C%D8%B3%DB%8C%D9%86" title="South Azerbaijani: اسیویسین" lang="azb" hreflang="azb" data-title="اسیویسین" data-language-autonym="تۆرکجه" data-language-local-name="South Azerbaijani" class="interlanguage-link-target"><span>تۆرکجه</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Acivicin" title="英語: Acivicin" lang="en" hreflang="en" data-title="Acivicin" data-language-autonym="English" data-language-local-name="英語" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%A7%D8%B3%DB%8C%D9%88%DB%8C%D8%B3%DB%8C%D9%86" title="ペルシア語: اسیویسین" lang="fa" hreflang="fa" data-title="اسیویسین" data-language-autonym="فارسی" data-language-local-name="ペルシア語" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Acivicin" title="セルボ・クロアチア語: Acivicin" lang="sh" hreflang="sh" data-title="Acivicin" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="セルボ・クロアチア語" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Acivicin" title="セルビア語: Acivicin" lang="sr" hreflang="sr" data-title="Acivicin" data-language-autonym="Српски / srpski" data-language-local-name="セルビア語" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E9%98%BF%E8%A5%BF%E7%BB%B4%E8%BE%9B" title="中国語: 阿西维辛" lang="zh" hreflang="zh" data-title="阿西维辛" data-language-autonym="中文" data-language-local-name="中国語" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q4674217#sitelinks-wikipedia" title="言語間リンクを編集" class="wbc-editpage">リンクを編集</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="名前空間"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/%E3%82%A2%E3%82%B7%E3%83%93%E3%82%B7%E3%83%B3" title="本文を閲覧 [c]" accesskey="c"><span>ページ</span></a></li><li id="ca-talk" class="new vector-tab-noicon mw-list-item"><a href="/w/index.php?title=%E3%83%8E%E3%83%BC%E3%83%88:%E3%82%A2%E3%82%B7%E3%83%93%E3%82%B7%E3%83%B3&action=edit&redlink=1" rel="discussion" class="new" title="「本文ページについての議論」 (存在しないページ) [t]" accesskey="t"><span>ノート</span></a></li> </ul> </div> </div> <div id="vector-variants-dropdown" class="vector-dropdown emptyPortlet" > <input type="checkbox" id="vector-variants-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-variants-dropdown" class="vector-dropdown-checkbox " aria-label="別の言語に切り替える" > <label id="vector-variants-dropdown-label" for="vector-variants-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">日本語</span> </label> <div class="vector-dropdown-content"> <div id="p-variants" class="vector-menu mw-portlet mw-portlet-variants emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> </div> </div> </nav> </div> <div id="right-navigation" class="vector-collapsible"> <nav aria-label="表示"> <div id="p-views" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-views" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-view" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/%E3%82%A2%E3%82%B7%E3%83%93%E3%82%B7%E3%83%B3"><span>閲覧</span></a></li><li id="ca-edit" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=%E3%82%A2%E3%82%B7%E3%83%93%E3%82%B7%E3%83%B3&action=edit" title="このページのソースコードを編集する [e]" accesskey="e"><span>編集</span></a></li><li id="ca-history" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=%E3%82%A2%E3%82%B7%E3%83%93%E3%82%B7%E3%83%B3&action=history" title="このページの過去の版 [h]" accesskey="h"><span>履歴表示</span></a></li> </ul> </div> </div> </nav> <nav class="vector-page-tools-landmark" aria-label="ページツール"> <div id="vector-page-tools-dropdown" class="vector-dropdown vector-page-tools-dropdown" > <input type="checkbox" id="vector-page-tools-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-tools-dropdown" class="vector-dropdown-checkbox " aria-label="ツール" > <label id="vector-page-tools-dropdown-label" for="vector-page-tools-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">ツール</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-tools-unpinned-container" class="vector-unpinned-container"> <div id="vector-page-tools" class="vector-page-tools vector-pinnable-element"> <div class="vector-pinnable-header vector-page-tools-pinnable-header vector-pinnable-header-unpinned" data-feature-name="page-tools-pinned" data-pinnable-element-id="vector-page-tools" data-pinned-container-id="vector-page-tools-pinned-container" data-unpinned-container-id="vector-page-tools-unpinned-container" > <div class="vector-pinnable-header-label">ツール</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-page-tools.pin">サイドバーに移動</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-page-tools.unpin">非表示</button> </div> <div id="p-cactions" class="vector-menu mw-portlet mw-portlet-cactions emptyPortlet vector-has-collapsible-items" title="その他の操作" > <div class="vector-menu-heading"> 操作 </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-more-view" class="selected vector-more-collapsible-item mw-list-item"><a href="/wiki/%E3%82%A2%E3%82%B7%E3%83%93%E3%82%B7%E3%83%B3"><span>閲覧</span></a></li><li id="ca-more-edit" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=%E3%82%A2%E3%82%B7%E3%83%93%E3%82%B7%E3%83%B3&action=edit" title="このページのソースコードを編集する [e]" accesskey="e"><span>編集</span></a></li><li id="ca-more-history" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=%E3%82%A2%E3%82%B7%E3%83%93%E3%82%B7%E3%83%B3&action=history"><span>履歴表示</span></a></li> </ul> </div> </div> <div id="p-tb" class="vector-menu mw-portlet mw-portlet-tb" > <div class="vector-menu-heading"> 全般 </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-whatlinkshere" class="mw-list-item"><a href="/wiki/%E7%89%B9%E5%88%A5:%E3%83%AA%E3%83%B3%E3%82%AF%E5%85%83/%E3%82%A2%E3%82%B7%E3%83%93%E3%82%B7%E3%83%B3" title="ここにリンクしている全ウィキページの一覧 [j]" accesskey="j"><span>リンク元</span></a></li><li id="t-recentchangeslinked" class="mw-list-item"><a href="/wiki/%E7%89%B9%E5%88%A5:%E9%96%A2%E9%80%A3%E3%83%9A%E3%83%BC%E3%82%B8%E3%81%AE%E6%9B%B4%E6%96%B0%E7%8A%B6%E6%B3%81/%E3%82%A2%E3%82%B7%E3%83%93%E3%82%B7%E3%83%B3" rel="nofollow" title="このページからリンクしているページの最近の更新 [k]" accesskey="k"><span>関連ページの更新状況</span></a></li><li id="t-upload" class="mw-list-item"><a href="/wiki/Wikipedia:%E3%83%95%E3%82%A1%E3%82%A4%E3%83%AB%E3%81%AE%E3%82%A2%E3%83%83%E3%83%97%E3%83%AD%E3%83%BC%E3%83%89" title="ファイルをアップロードする [u]" accesskey="u"><span>ファイルをアップロード</span></a></li><li id="t-specialpages" class="mw-list-item"><a href="/wiki/%E7%89%B9%E5%88%A5:%E7%89%B9%E5%88%A5%E3%83%9A%E3%83%BC%E3%82%B8%E4%B8%80%E8%A6%A7" title="特別ページの一覧 [q]" accesskey="q"><span>特別ページ</span></a></li><li id="t-permalink" class="mw-list-item"><a href="/w/index.php?title=%E3%82%A2%E3%82%B7%E3%83%93%E3%82%B7%E3%83%B3&oldid=101108012" title="このページのこの版への固定リンク"><span>この版への固定リンク</span></a></li><li id="t-info" class="mw-list-item"><a href="/w/index.php?title=%E3%82%A2%E3%82%B7%E3%83%93%E3%82%B7%E3%83%B3&action=info" title="このページについての詳細情報"><span>ページ情報</span></a></li><li id="t-cite" class="mw-list-item"><a href="/w/index.php?title=%E7%89%B9%E5%88%A5:%E3%81%93%E3%81%AE%E3%83%9A%E3%83%BC%E3%82%B8%E3%82%92%E5%BC%95%E7%94%A8&page=%E3%82%A2%E3%82%B7%E3%83%93%E3%82%B7%E3%83%B3&id=101108012&wpFormIdentifier=titleform" title="このページの引用方法"><span>このページを引用</span></a></li><li id="t-urlshortener" class="mw-list-item"><a href="/w/index.php?title=%E7%89%B9%E5%88%A5:UrlQ%C4%B1sald%C4%B1c%C4%B1s%C4%B1&url=https%3A%2F%2Fja.wikipedia.org%2Fwiki%2F%25E3%2582%25A2%25E3%2582%25B7%25E3%2583%2593%25E3%2582%25B7%25E3%2583%25B3"><span>短縮URLを取得する</span></a></li><li id="t-urlshortener-qrcode" class="mw-list-item"><a href="/w/index.php?title=%E7%89%B9%E5%88%A5:QrKodu&url=https%3A%2F%2Fja.wikipedia.org%2Fwiki%2F%25E3%2582%25A2%25E3%2582%25B7%25E3%2583%2593%25E3%2582%25B7%25E3%2583%25B3"><span>QRコードをダウンロード</span></a></li> </ul> </div> </div> <div id="p-coll-print_export" class="vector-menu mw-portlet mw-portlet-coll-print_export" > <div class="vector-menu-heading"> 印刷/書き出し </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="coll-create_a_book" class="mw-list-item"><a href="/w/index.php?title=%E7%89%B9%E5%88%A5:%E3%83%96%E3%83%83%E3%82%AF&bookcmd=book_creator&referer=%E3%82%A2%E3%82%B7%E3%83%93%E3%82%B7%E3%83%B3"><span>ブックの新規作成</span></a></li><li id="coll-download-as-rl" class="mw-list-item"><a href="/w/index.php?title=%E7%89%B9%E5%88%A5:DownloadAsPdf&page=%E3%82%A2%E3%82%B7%E3%83%93%E3%82%B7%E3%83%B3&action=show-download-screen"><span>PDF 形式でダウンロード</span></a></li><li id="t-print" class="mw-list-item"><a href="/w/index.php?title=%E3%82%A2%E3%82%B7%E3%83%93%E3%82%B7%E3%83%B3&printable=yes" title="このページの印刷用ページ [p]" accesskey="p"><span>印刷用バージョン</span></a></li> </ul> </div> </div> <div id="p-wikibase-otherprojects" class="vector-menu mw-portlet mw-portlet-wikibase-otherprojects" > <div class="vector-menu-heading"> 他のプロジェクト </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-wikibase" class="wb-otherproject-link wb-otherproject-wikibase-dataitem mw-list-item"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q4674217" title="関連付けられたデータリポジトリ項目へのリンク [g]" accesskey="g"><span>ウィキデータ項目</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> </div> </div> </div> <div class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="ページツール"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="表示"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">表示</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">サイドバーに移動</button> <button class="vector-pinnable-header-toggle-button 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src="//upload.wikimedia.org/wikipedia/commons/thumb/7/7f/Acivicin_structure.svg/200px-Acivicin_structure.svg.png" decoding="async" width="200" height="131" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/7f/Acivicin_structure.svg/300px-Acivicin_structure.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/7f/Acivicin_structure.svg/400px-Acivicin_structure.svg.png 2x" data-file-width="512" data-file-height="336" /></a></span> </td></tr> <tr> <td align="center" colspan="2"><div class="NavFrame" style="border:none; padding:0;"><div class="NavHead" style="width:96%; background:transparent;text-align:center;"><a href="/wiki/IUPAC%E5%91%BD%E5%90%8D%E6%B3%95" title="IUPAC命名法">IUPAC名</a></div><div class="NavContent" style="width:96%; background:transparent;text-align:center;"><p style="word-wrap: break-word;">(2<i>S</i>)-Amino[(5<i>S</i>)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl]ethanoic acid</p></div></div> </td></tr> <tr> <td align="center" colspan="2"><div class="NavFrame" style="border:none; padding:0;"><div class="NavHead" style="width:96%; background:transparent;text-align:center;">別称</div><div class="NavContent" style="width:96%; background:transparent;text-align:center;">Antibiotic AT 125</div></div> </td></tr> <tr> <th style="background: #d6e0dc; text-align: center;" colspan="2">識別情報 </th></tr> <tr> <td><span style="white-space:nowrap;"><a href="/wiki/CAS%E7%99%BB%E9%8C%B2%E7%95%AA%E5%8F%B7" title="CAS登録番号">CAS登録番号</a></span> </td> <td><span class="reflink plainlinks nourlexpansion"><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?ref=42228-92-2">42228-92-2</a></span><sup> <span typeof="mw:File"><a href="/wiki/%E3%83%95%E3%82%A1%E3%82%A4%E3%83%AB:Cross_reject.svg" class="mw-file-description" title="×"><img alt="×" src="//upload.wikimedia.org/wikipedia/commons/thumb/5/57/Cross_reject.svg/7px-Cross_reject.svg.png" decoding="async" width="7" height="7" class="mw-file-element" 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href="https://www.ebi.ac.uk/chebi/searchId.do?chebiId=74545">CHEBI:74545</a></span><sup> <span typeof="mw:File"><a href="/wiki/%E3%83%95%E3%82%A1%E3%82%A4%E3%83%AB:Cross_reject.svg" class="mw-file-description" title="×"><img alt="×" src="//upload.wikimedia.org/wikipedia/commons/thumb/5/57/Cross_reject.svg/7px-Cross_reject.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/57/Cross_reject.svg/11px-Cross_reject.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/57/Cross_reject.svg/14px-Cross_reject.svg.png 2x" data-file-width="512" data-file-height="512" /></a></span></sup></li></ul></div> </td></tr> <tr> <td><a href="/wiki/ChEMBL" class="mw-redirect" title="ChEMBL">ChEMBL</a> </td> <td><span title="www.ebi.ac.uk/chembldb"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1231101/">CHEMBL1231101</a></span><sup> <span typeof="mw:File"><a 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margin-top: 0; margin-bottom: 0; line-height: inherit;"><li style="line-height: inherit; margin: 0"><div style="border-top:1px solid #ccc; padding:0.4em 0.2em 0.2em 0.2em; word-wrap:break-word; text-indent:0em; text-align:left; font-size:11px; line-height:120%;">Cl\C1=N\O[C@H]([C@@H](C(=O)O)N)C1</div></li></ul> </div> </td></tr> <tr> <td colspan="2"><div class="NavFrame collapsed" style="border: none; padding: 0;"> <div class="NavHead" style="font-size: 105%; background: transparent; text-align: left; text-align:center; font-weight:bold; background:transparent;"><a href="/wiki/%E5%9B%BD%E9%9A%9B%E5%8C%96%E5%AD%A6%E7%89%A9%E8%B3%AA%E8%AD%98%E5%88%A5%E5%AD%90" class="mw-redirect" title="国際化学物質識別子">InChI</a></div> <ul class="NavContent" style="list-style: none none; margin-left: 0; text-align:left;word-break:break-all; font-size: 105%; margin-top: 0; margin-bottom: 0; line-height: inherit;"><li style="line-height: inherit; margin: 0"><div style="border-top:1px solid #ccc; padding:0.2em 0 0.2em 1.5em; text-align:left;"><div style="word-wrap:break-word; text-indent:-1.5em; font-size:11px; line-height:120%;">InChI=1S/C5H7ClN2O3/c6-3-1-2(11-8-3)4(7)5(9)10/h2,4H,1,7H2,(H,9,10)/t2-,4-/m0/s1<sup> <span typeof="mw:File"><a href="/wiki/%E3%83%95%E3%82%A1%E3%82%A4%E3%83%AB:Antu_mail-mark-notjunk.svg" class="mw-file-description" title="チェック"><img alt="チェック" src="//upload.wikimedia.org/wikipedia/commons/thumb/b/b1/Antu_mail-mark-notjunk.svg/7px-Antu_mail-mark-notjunk.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/b1/Antu_mail-mark-notjunk.svg/11px-Antu_mail-mark-notjunk.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/b1/Antu_mail-mark-notjunk.svg/14px-Antu_mail-mark-notjunk.svg.png 2x" data-file-width="512" data-file-height="512" /></a></span></sup></div><div style="word-wrap:break-word; text-indent:-1.5em; font-size:11px; line-height:120%;">Key: QAWIHIJWNYOLBE-OKKQSCSOSA-N<sup> <span typeof="mw:File"><a href="/wiki/%E3%83%95%E3%82%A1%E3%82%A4%E3%83%AB:Antu_mail-mark-notjunk.svg" class="mw-file-description" title="チェック"><img alt="チェック" src="//upload.wikimedia.org/wikipedia/commons/thumb/b/b1/Antu_mail-mark-notjunk.svg/7px-Antu_mail-mark-notjunk.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/b1/Antu_mail-mark-notjunk.svg/11px-Antu_mail-mark-notjunk.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/b1/Antu_mail-mark-notjunk.svg/14px-Antu_mail-mark-notjunk.svg.png 2x" data-file-width="512" data-file-height="512" /></a></span></sup></div></div></li><li style="line-height: inherit; margin: 0"><div style="border-top:1px solid #ccc; padding:0.2em 0 0.2em 1.5em; text-align:left;"><div style="word-wrap:break-word; text-indent:-1.5em; font-size:11px; line-height:120%;">InChI=1S/C5H7ClN2O3/c6-3-1-2(11-8-3)4(7)5(9)10/h2,4H,1,7H2,(H,9,10)/t2-,4-/m0/s1</div></div></li></ul> </div> </td></tr> <tr> <th colspan="2" style="background-color: #d6e0dc; text-align: center;">特性 </th></tr> <tr> <td><a href="/wiki/%E5%8C%96%E5%AD%A6%E5%BC%8F" title="化学式">化学式</a> </td> <td>C<sub>5</sub>H<sub>7</sub>ClN<sub>2</sub>O<sub>3</sub> </td></tr> <tr> <td><a href="/wiki/%E3%83%A2%E3%83%AB%E8%B3%AA%E9%87%8F" title="モル質量">モル質量</a> </td> <td>178.57 g mol<sup>−1</sup> </td></tr> <tr> <td colspan="2" style="background-color: #d6e0dc; text-align: center; font-size: 80%;">特記なき場合、データは<a href="/wiki/%E5%B8%B8%E6%B8%A9" title="常温">常温</a> (25 <span lang="en">°C</span>)・<a href="/wiki/%E5%B8%B8%E5%9C%A7" class="mw-redirect" title="常圧">常圧</a> (100 kPa) におけるものである。 </td></tr></tbody></table> <p><b>アシビシン</b>(Acivicin)は<a href="/wiki/%E3%82%B0%E3%83%AB%E3%82%BF%E3%83%9F%E3%83%B3" title="グルタミン">グルタミン</a>のアナログで、<a href="/wiki/%CE%93-%E3%82%B0%E3%83%AB%E3%82%BF%E3%83%9F%E3%83%AB%E3%83%88%E3%83%A9%E3%83%B3%E3%82%B9%E3%83%95%E3%82%A7%E3%83%A9%E3%83%BC%E3%82%BC" title="Γ-グルタミルトランスフェラーゼ">γ-グルタミルトランスフェラーゼ</a>の阻害剤である。 </p><p><i>Streptomyces sviceus</i>の発酵産物である<sup id="cite_ref-Allen_1-0" class="reference"><a href="#cite_note-Allen-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>。<a href="/wiki/%E3%82%B0%E3%83%AB%E3%82%BF%E3%83%9F%E3%83%B3%E9%85%B8" title="グルタミン酸">グルタミン酸</a>の代謝を妨げ、グルタミン酸依存性の酵素合成を阻害し、そのため<a href="/w/index.php?title=%E5%9B%BA%E5%BD%A2%E8%85%AB%E7%98%8D&action=edit&redlink=1" class="new" title="「固形腫瘍」 (存在しないページ)">固形腫瘍</a>の治療に役立つと期待されている<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup>。 </p><p>1972年に発見されて以降、<a href="/wiki/%E6%8A%97%E3%81%8C%E3%82%93%E5%89%A4" title="抗がん剤">抗がん剤</a>として研究されてきたが、その毒性のために試みは上手く行っていない<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> 。 </p> <div class="mw-heading mw-heading2"><h2 id="研究"><span id=".E7.A0.94.E7.A9.B6"></span>研究</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E3%82%A2%E3%82%B7%E3%83%93%E3%82%B7%E3%83%B3&action=edit&section=1" title="節を編集: 研究"><span>編集</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/wiki/In_vitro" title="In vitro">in vitro</a>での研究により、濃度5 μMのアシビシンは、72時間の連続培養において、ヒト膵臓癌腫細胞(MIA PaCa-2)の成長を78%阻害することが示された。また、濃度450 μMでは、MIA PaCa-2のγ-グルタミルトランスペプチダーゼを半減期80分で不可逆的に不活化した<sup id="cite_ref-Allen_1-1" class="reference"><a href="#cite_note-Allen-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>。 </p> <div class="mw-heading mw-heading2"><h2 id="出典"><span id=".E5.87.BA.E5.85.B8"></span>出典</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E3%82%A2%E3%82%B7%E3%83%93%E3%82%B7%E3%83%B3&action=edit&section=2" title="節を編集: 出典"><span>編集</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="reflist" style="list-style-type: decimal;"> <ol class="references"> <li id="cite_note-Allen-1">^ <a href="#cite_ref-Allen_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Allen_1-1"><sup><i><b>b</b></i></sup></a> <span class="reference-text"><cite style="font-style:normal" class="citation journal">Allen, L.; Meck, R.; Yunis, A. (1980). “The Inhibition of γ-Glutamyl Transpeptidase from Human Pancreatic Carcinoma Cells by (αS,5S)-α-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic Acid (AT-125; NSC-163501)”. <i>Research Communications in Chemical Pathology and Pharmacology</i> <b>27</b> (1): 175-182. <style data-mw-deduplicate="TemplateStyles:r101121245">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation.cs-ja1 q,.mw-parser-output .citation.cs-ja2 q{quotes:"「""」""『""』"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free a,.mw-parser-output .citation .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited a,.mw-parser-output .id-lock-registration a,.mw-parser-output .citation .cs1-lock-limited a,.mw-parser-output .citation .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription a,.mw-parser-output .citation .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:var(--color-success,#3a3);margin-left:0.3em}.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}</style><a href="/wiki/PMID_(%E8%AD%98%E5%88%A5%E5%AD%90)" class="mw-redirect" title="PMID (識別子)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/6102405/">6102405</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+Inhibition+of+%CE%B3-Glutamyl+Transpeptidase+from+Human+Pancreatic+Carcinoma+Cells+by+%28%CE%B1S%2C5S%29-%CE%B1-Amino-3-chloro-4%2C5-dihydro-5-isoxazoleacetic+Acid+%28AT-125%3B+NSC-163501%29&rft.jtitle=Research+Communications+in+Chemical+Pathology+and+Pharmacology&rft.aulast=Allen&rft.aufirst=L.&rft.au=Allen%2C%26%2332%3BL.&rft.au=Meck%2C%26%2332%3BR.&rft.au=Yunis%2C%26%2332%3BA.&rft.date=1980&rft.volume=27&rft.issue=1&rft.pages=175-182&rft_id=info:pmid/6102405&rfr_id=info:sid/ja.wikipedia.org:%E3%82%A2%E3%82%B7%E3%83%93%E3%82%B7%E3%83%B3"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-2"><b><a href="#cite_ref-2">^</a></b> <span class="reference-text"><cite style="font-style:normal" class="citation journal">Hidalgo, M.; Rodriguez, G.; Kuhn, J. G.; Brown, T.; Weiss, G.; MacGovren, J. P.; von Hoff, D. D.; Rowinsky, E. K. (1998). “A Phase I and Pharmacological Study of the Glutamine Antagonist Acivicin with the Amino Acid Solution Aminosyn in Patients with Advanced Solid Malignancies”. <i>Clinical Cancer Research</i> <b>4</b> (11): 2763-2770. <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r101121245"><a href="/wiki/PMID_(%E8%AD%98%E5%88%A5%E5%AD%90)" class="mw-redirect" title="PMID (識別子)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/9829740/">9829740</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+Phase+I+and+Pharmacological+Study+of+the+Glutamine+Antagonist+Acivicin+with+the+Amino+Acid+Solution+Aminosyn+in+Patients+with+Advanced+Solid+Malignancies&rft.jtitle=Clinical+Cancer+Research&rft.aulast=Hidalgo&rft.aufirst=M.&rft.au=Hidalgo%2C%26%2332%3BM.&rft.au=Rodriguez%2C%26%2332%3BG.&rft.au=Kuhn%2C%26%2332%3BJ.+G.&rft.au=Brown%2C%26%2332%3BT.&rft.au=Weiss%2C%26%2332%3BG.&rft.au=MacGovren%2C%26%2332%3BJ.+P.&rft.au=von+Hoff%2C%26%2332%3BD.+D.&rft.au=Rowinsky%2C%26%2332%3BE.+K.&rft.date=1998&rft.volume=4&rft.issue=11&rft.pages=2763-2770&rft_id=info:pmid/9829740&rfr_id=info:sid/ja.wikipedia.org:%E3%82%A2%E3%82%B7%E3%83%93%E3%82%B7%E3%83%B3"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-3"><b><a href="#cite_ref-3">^</a></b> <span class="reference-text"><a rel="nofollow" class="external free" href="http://pubs.rsc.org/en/content/articlehtml/2015/sc/c4sc02339k">http://pubs.rsc.org/en/content/articlehtml/2015/sc/c4sc02339k</a></span> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="外部リンク"><span id=".E5.A4.96.E9.83.A8.E3.83.AA.E3.83.B3.E3.82.AF"></span>外部リンク</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E3%82%A2%E3%82%B7%E3%83%93%E3%82%B7%E3%83%B3&action=edit&section=3" title="節を編集: 外部リンク"><span>編集</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><cite style="font-style:normal" class="citation journal">Obrador, E.; Carretero, J.; Ortega, A.; Medina, I.; Rodilla, V.; Pellicer, J. A.; Estrela, J. M. (2002). “γ-Glutamyl Transpeptidase Overexpression Increases Metastatic Growth of B16 Melanoma Cells in the Mouse Liver”. <i>Hepatology</i> <b>35</b> (1): 74-81. <a href="/wiki/Doi_(%E8%AD%98%E5%88%A5%E5%AD%90)" class="mw-redirect" title="Doi (識別子)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1053%2Fjhep.2002.30277">10.1053/jhep.2002.30277</a>. <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r101121245"><a href="/wiki/PMID_(%E8%AD%98%E5%88%A5%E5%AD%90)" class="mw-redirect" title="PMID (識別子)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/11786961/">11786961</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%CE%B3-Glutamyl+Transpeptidase+Overexpression+Increases+Metastatic+Growth+of+B16+Melanoma+Cells+in+the+Mouse+Liver&rft.jtitle=Hepatology&rft.aulast=Obrador&rft.aufirst=E.&rft.au=Obrador%2C%26%2332%3BE.&rft.au=Carretero%2C%26%2332%3BJ.&rft.au=Ortega%2C%26%2332%3BA.&rft.au=Medina%2C%26%2332%3BI.&rft.au=Rodilla%2C%26%2332%3BV.&rft.au=Pellicer%2C%26%2332%3BJ.+A.&rft.au=Estrela%2C%26%2332%3BJ.+M.&rft.date=2002&rft.volume=35&rft.issue=1&rft.pages=74-81&rft_id=info:doi/10.1053%2Fjhep.2002.30277&rft_id=info:pmid/11786961&rfr_id=info:sid/ja.wikipedia.org:%E3%82%A2%E3%82%B7%E3%83%93%E3%82%B7%E3%83%B3"><span style="display: none;"> </span></span></li> <li><cite style="font-style:normal" class="citation journal">Schmees, C.; Prinz, C.; Treptau, T.; Rad, R.; Hengst, L.; Voland, P.; Bauer, S.; Brenner, L. et al. (2007). “Inhibition of T-Cell Proliferation by <i>Helicobacter pylori</i> γ-Glutamyl Transpeptidase”. <i>Gastroenterology</i> <b>132</b> (5): 1820-1833. <a href="/wiki/Doi_(%E8%AD%98%E5%88%A5%E5%AD%90)" class="mw-redirect" title="Doi (識別子)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1053%2Fj.gastro.2007.02.031">10.1053/j.gastro.2007.02.031</a>. <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r101121245"><a href="/wiki/PMID_(%E8%AD%98%E5%88%A5%E5%AD%90)" class="mw-redirect" title="PMID (識別子)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/17484877/">17484877</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Inhibition+of+T-Cell+Proliferation+by+%27%27Helicobacter+pylori%27%27+%CE%B3-Glutamyl+Transpeptidase&rft.jtitle=Gastroenterology&rft.aulast=Schmees&rft.aufirst=C.&rft.au=Schmees%2C%26%2332%3BC.&rft.au=Prinz%2C%26%2332%3BC.&rft.au=Treptau%2C%26%2332%3BT.&rft.au=Rad%2C%26%2332%3BR.&rft.au=Hengst%2C%26%2332%3BL.&rft.au=Voland%2C%26%2332%3BP.&rft.au=Bauer%2C%26%2332%3BS.&rft.au=Brenner%2C%26%2332%3BL.&rft.au=Schmid%2C%26%2332%3BR.+M.&rft.date=2007&rft.volume=132&rft.issue=5&rft.pages=1820-1833&rft_id=info:doi/10.1053%2Fj.gastro.2007.02.031&rft_id=info:pmid/17484877&rfr_id=info:sid/ja.wikipedia.org:%E3%82%A2%E3%82%B7%E3%83%93%E3%82%B7%E3%83%B3"><span style="display: none;"> </span></span></li></ul>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?useformat=desktop&type=1x1&usesul3=0" alt="" width="1" height="1" style="border: none; position: 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