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mw-list-item"><a href="https://de.wikipedia.org/wiki/Ixekizumab" title="Ixekizumab – German" lang="de" hreflang="de" data-title="Ixekizumab" data-language-autonym="Deutsch" data-language-local-name="German" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%A7%DB%8C%DA%A9%D8%B3%DB%8C%DA%A9%DB%8C%D8%B2%D9%88%D9%85%D8%A7%D8%A8" title="ایکسیکیزوماب – Persian" lang="fa" hreflang="fa" data-title="ایکسیکیزوماب" data-language-autonym="فارسی" data-language-local-name="Persian" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Ixekizumab" title="Ixekizumab – French" lang="fr" hreflang="fr" data-title="Ixekizumab" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Ixekizumab" title="Ixekizumab – Italian" lang="it" hreflang="it" data-title="Ixekizumab" data-language-autonym="Italiano" data-language-local-name="Italian" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-or mw-list-item"><a href="https://or.wikipedia.org/wiki/%E0%AC%87%E0%AC%95%E0%AD%8D%E0%AC%B8%E0%AD%87%E0%AC%95%E0%AC%BF%E0%AC%9C%E0%AD%81%E0%AC%AE%E0%AC%BE%E0%AC%AC" title="ଇକ୍ସେକିଜୁମାବ – Odia" lang="or" hreflang="or" data-title="ଇକ୍ସେକିଜୁମାବ" data-language-autonym="ଓଡ଼ିଆ" data-language-local-name="Odia" class="interlanguage-link-target"><span>ଓଡ଼ିଆ</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%98%D0%BA%D1%81%D0%B5%D0%BA%D0%B8%D0%B7%D1%83%D0%BC%D0%B0%D0%B1" title="Иксекизумаб – Russian" lang="ru" hreflang="ru" data-title="Иксекизумаб" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Ixekizumab" title="Ixekizumab – Swedish" lang="sv" hreflang="sv" data-title="Ixekizumab" data-language-autonym="Svenska" data-language-local-name="Swedish" class="interlanguage-link-target"><span>Svenska</span></a></li><li class="interlanguage-link interwiki-te mw-list-item"><a href="https://te.wikipedia.org/wiki/%E0%B0%87%E0%B0%95%E0%B1%8D%E0%B0%B8%E0%B1%86%E0%B0%95%E0%B0%BF%E0%B0%9C%E0%B1%81%E0%B0%AE%E0%B0%BE%E0%B0%AC%E0%B1%8D" title="ఇక్సెకిజుమాబ్ – Telugu" lang="te" hreflang="te" data-title="ఇక్సెకిజుమాబ్" data-language-autonym="తెలుగు" data-language-local-name="Telugu" class="interlanguage-link-target"><span>తెలుగు</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E4%BE%9D%E5%A5%87%E7%8F%A0%E5%96%AE%E6%8A%97" title="依奇珠單抗 – Chinese" lang="zh" hreflang="zh" data-title="依奇珠單抗" data-language-autonym="中文" data-language-local-name="Chinese" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q13574436#sitelinks-wikipedia" title="Edit interlanguage links" class="wbc-editpage">Edit links</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Namespaces"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Ixekizumab" title="View the content page [c]" accesskey="c"><span>Article</span></a></li><li id="ca-talk" 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href="/w/index.php?title=Taltz&redirect=no" class="mw-redirect" title="Taltz">Taltz</a>)</span></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Medication used to treat autoimmune diseases</div> <p class="mw-empty-elt"> </p> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox" style="border-spacing:2px;"><caption class="infobox-title"><span title="International nonproprietary name (INN): Ixekizumab">Ixekizumab</span></caption><tbody><tr><th colspan="2" class="infobox-header" style="background:#ddd"><a href="/wiki/Monoclonal_antibody" title="Monoclonal antibody">Monoclonal antibody</a></th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/File:Engineered_monoclonal_antibodies.svg" title="File:Engineered monoclonal antibodies.svg">Type</a></th><td class="infobox-data">Whole antibody</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Monoclonal_antibody#Production" title="Monoclonal antibody">Source</a></th><td class="infobox-data"><a href="/wiki/Humanized" class="mw-redirect" title="Humanized">Humanized</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Antigen" title="Antigen">Target</a></th><td class="infobox-data"><a href="/wiki/Interleukin_17A" class="mw-redirect" title="Interleukin 17A">Interleukin 17A</a> (IL-17A)</td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Clinical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;">Pronunciation</th><td class="infobox-data">ix-ee-KIZ-ue-mab<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Drug_nomenclature#Trade_names" title="Drug nomenclature">Trade names</a></th><td class="infobox-data">Taltz</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/American_Society_of_Health-System_Pharmacists" title="American Society of Health-System Pharmacists">AHFS</a>/<a href="/wiki/Drugs.com" title="Drugs.com">Drugs.com</a></th><td class="infobox-data"><span title="www.drugs.com"><a rel="nofollow" class="external text" href="https://www.drugs.com/monograph/ixekizumab.html">Monograph</a></span></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/MedlinePlus" title="MedlinePlus">MedlinePlus</a></th><td class="infobox-data"><span title="medlineplus.gov"><a rel="nofollow" class="external text" href="https://medlineplus.gov/druginfo/meds/a616025.html">a616025</a></span></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Regulation_of_therapeutic_goods" title="Regulation of therapeutic goods">License data</a></th><td class="infobox-data"><style data-mw-deduplicate="TemplateStyles:r1126788409">.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}</style><div class="plainlist"> <ul><li><small><abbr class="country-name" title="United States">US</abbr></small> <a href="/wiki/DailyMed" title="DailyMed">DailyMed</a>: <span title="dailymed.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=Ixekizumab">Ixekizumab</a></span></li></ul></div> </td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Pregnancy_category" title="Pregnancy category">Pregnancy<br />category</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"> <ul><li><small><abbr class="country-name" title="Australia">AU</abbr>:</small> C<sup id="cite_ref-Drugs.com_pregnancy_2-0" class="reference"><a href="#cite_note-Drugs.com_pregnancy-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></li> <li class="mw-empty-elt"></li></ul> </div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Route_of_administration" title="Route of administration">Routes of<br />administration</a></th><td class="infobox-data"><a href="/wiki/Subcutaneous_injection" class="mw-redirect" title="Subcutaneous injection">Subcutaneous injection</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Anatomical_Therapeutic_Chemical_Classification_System" title="Anatomical Therapeutic Chemical Classification System">ATC code</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><a href="/wiki/ATC_code_L04" title="ATC code L04">L04AC13</a> (<span title="www.whocc.no"><a rel="nofollow" class="external text" href="https://www.whocc.no/atc_ddd_index/?code=L04AC13">WHO</a></span>) </li></ul></div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Legal status</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Regulation_of_therapeutic_goods" title="Regulation of therapeutic goods">Legal status</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"> <ul><li><small><abbr class="country-name" title="Australia">AU</abbr>:</small> <a href="/wiki/Standard_for_the_Uniform_Scheduling_of_Medicines_and_Poisons#Schedule_4" title="Standard for the Uniform Scheduling of Medicines and Poisons">S4</a> (Prescription only)<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></li> <li><small><abbr class="country-name" title="Canada">CA</abbr></small>: <a href="/wiki/Prescription_drug" title="Prescription drug"> ℞-only</a><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></li> <li><small><abbr class="country-name" title="United Kingdom">UK</abbr>:</small> <a href="/wiki/Prescription_drug" title="Prescription drug">POM</a> (Prescription only)<sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup></li> <li><small><abbr class="country-name" title="United States">US</abbr>:</small> <a href="/wiki/Prescription_drug" title="Prescription drug">℞-only</a></li> <li><small><abbr class="country-name" title="European Union">EU</abbr>:</small> Rx-only<sup id="cite_ref-Taltz_EPAR_6-0" class="reference"><a href="#cite_note-Taltz_EPAR-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup></li> <li>In general: ℞ (Prescription only)</li></ul></div> </td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd"><a href="/wiki/Pharmacokinetics" title="Pharmacokinetics">Pharmacokinetic</a> data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Bioavailability" title="Bioavailability">Bioavailability</a></th><td class="infobox-data">60–81%<sup id="cite_ref-Vu2016_7-0" class="reference"><a href="#cite_note-Vu2016-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Drug_metabolism" title="Drug metabolism">Metabolism</a></th><td class="infobox-data">Presumably <a href="/wiki/Proteolysis" title="Proteolysis">proteolysis</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Biological_half-life" title="Biological half-life">Elimination <span class="nowrap">half-life</span></a></th><td class="infobox-data">13 days<sup id="cite_ref-Kiwalkar2019_8-0" class="reference"><a href="#cite_note-Kiwalkar2019-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CAS_Registry_Number" title="CAS Registry Number">CAS Number</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="commonchemistry.cas.org"><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=1143503-69-8">1143503-69-8</a></span><sup> <span typeof="mw:File"><span><img alt="☒" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/7px-X_mark.svg.png" decoding="async" width="7" height="8" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/11px-X_mark.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/14px-X_mark.svg.png 2x" data-file-width="525" data-file-height="600" /></span></span><span style="display:none">N</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/DrugBank" title="DrugBank">DrugBank</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.drugbank.ca"><a rel="nofollow" class="external text" href="https://www.drugbank.ca/drugs/DB11569">DB11569</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChemSpider" title="ChemSpider">ChemSpider</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li>none</li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Unique_Ingredient_Identifier" title="Unique Ingredient Identifier">UNII</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="precision.fda.gov"><a rel="nofollow" class="external text" href="https://precision.fda.gov/uniisearch/srs/unii/BTY153760O">BTY153760O</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/KEGG" title="KEGG">KEGG</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.kegg.jp"><a rel="nofollow" class="external text" href="https://www.kegg.jp/entry/D10071">D10071</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChEMBL" title="ChEMBL">ChEMBL</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chembl/explore/compound/ChEMBL1743034">ChEMBL1743034</a></span></li></ul></div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Chemical and physical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Chemical_formula" title="Chemical formula">Formula</a></th><td class="infobox-data"><span title="Carbon">C</span><sub>6492</sub><span title="Hydrogen">H</span><sub>10012</sub><span title="Nitrogen">N</span><sub>1728</sub><span title="Oxygen">O</span><sub>2028</sub><span title="Sulfur">S</span><sub>46</sub></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Molar_mass" title="Molar mass">Molar mass</a></th><td class="infobox-data"><span class="nowrap"><span data-sort-value="7005146192340000000♠"></span>146<span style="margin-left:.25em;">192</span>.34</span> g·mol<sup>−1</sup></td></tr><tr><td colspan="2" class="infobox-below"><style data-mw-deduplicate="TemplateStyles:r886047488">.mw-parser-output .nobold{font-weight:normal}</style><span class="nobold"> <sup><span typeof="mw:File"><span><img alt="☒" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/7px-X_mark.svg.png" decoding="async" width="7" height="8" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/11px-X_mark.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/14px-X_mark.svg.png 2x" data-file-width="525" data-file-height="600" /></span></span><span style="display:none">N</span><span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup> <a href="/wiki/Wikipedia:WikiProject_Chemicals/Chembox_validation" title="Wikipedia:WikiProject Chemicals/Chembox validation">(what is this?)</a></span><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r886047488"><span class="nobold">  <span class="reflink plainlinks nourlexpansion"><a class="external text" href="https://en.wikipedia.org/w/index.php?title=Special:ComparePages&rev1=458270595&page2=Ixekizumab">(verify)</a></span></span></td></tr></tbody></table> <p><b>Ixekizumab</b>, sold under the brand name <b>Taltz</b>, is an injectable medication for the treatment of <a href="/wiki/Autoimmune_disease" title="Autoimmune disease">autoimmune diseases</a>. Chemically, it is a form of a humanized <a href="/wiki/Monoclonal_antibody" title="Monoclonal antibody">monoclonal antibody</a>.<sup id="cite_ref-USAN_9-0" class="reference"><a href="#cite_note-USAN-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> The substance acts by binding <a href="/wiki/Interleukin_17A" class="mw-redirect" title="Interleukin 17A">interleukin 17A</a> and neutralizing it, reducing <a href="/wiki/Inflammation" title="Inflammation">inflammation</a>.<sup id="cite_ref-AC_10-0" class="reference"><a href="#cite_note-AC-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> </p><p>The most common side effects include upper respiratory infections, injection site reactions and fungal (<a href="/wiki/Tinea" class="mw-redirect" title="Tinea">tinea</a>) infections.<sup id="cite_ref-FDA_PR_20160322_12-0" class="reference"><a href="#cite_note-FDA_PR_20160322-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> </p><p>The drug was developed by <a href="/wiki/Eli_Lilly_and_Company" title="Eli Lilly and Company">Eli Lilly and Co.</a> and is approved for the treatment of <a href="/wiki/Plaque_psoriasis" class="mw-redirect" title="Plaque psoriasis">plaque psoriasis</a> in the European Union and the United States as of 2016.<sup id="cite_ref-Taltz_EPAR_6-1" class="reference"><a href="#cite_note-Taltz_EPAR-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Medical_uses">Medical uses</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Ixekizumab&action=edit&section=1" title="Edit section: Medical uses"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>In the United States, ixekizumab is <a href="/wiki/Indication_(medicine)" title="Indication (medicine)">indicated</a> for the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy, active psoriatic arthritis, active ankylosing spondylitis, and active non-radiographic axial spondyloarthritis with objective signs of inflammation.<sup id="cite_ref-Taltz_FDA_label_14-0" class="reference"><a href="#cite_note-Taltz_FDA_label-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> In the European Union it is indicated for the treatment of moderate-to-severe plaque psoriasis<sup id="cite_ref-Taltz_EPAR_6-2" class="reference"><a href="#cite_note-Taltz_EPAR-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> and as a second-line therapy for active <a href="/wiki/Psoriatic_arthritis" title="Psoriatic arthritis">psoriatic arthritis</a>.<sup id="cite_ref-Taltz_EPAR_6-3" class="reference"><a href="#cite_note-Taltz_EPAR-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-AC_10-1" class="reference"><a href="#cite_note-AC-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p><p>In studies, the drug reduced the <a href="/wiki/Psoriasis_Area_and_Severity_Index" title="Psoriasis Area and Severity Index">Psoriasis Area and Severity Index</a> by at least 75% (PASI75) in 82–89% of patients during the first three months of treatment (depending on the dosing scheme), and 40% of patients experienced a complete absence of psoriasis symptoms (PASI100). In the <a href="/wiki/Placebo" title="Placebo">placebo</a> group, PASI75 was reached in 4% of patients, and PASI100 in none; in the group of patients receiving <a href="/wiki/Etanercept" title="Etanercept">etanercept</a>, an older anti-psoriasis drug, PASI75 was reached in 48%. Until the 60th study week, 11–44% of ixekizumab treated patients relapsed (again, depending on the dosing scheme), as compared to 84% under placebo.<sup id="cite_ref-AC_10-2" class="reference"><a href="#cite_note-AC-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Contraindications">Contraindications</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Ixekizumab&action=edit&section=2" title="Edit section: Contraindications"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The medication is contraindicated for patients with certain infections such as active <a href="/wiki/Tuberculosis" title="Tuberculosis">tuberculosis</a>.<sup id="cite_ref-AC_10-3" class="reference"><a href="#cite_note-AC-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup class="noprint Inline-Template" style="white-space:nowrap;">[<i><a href="/wiki/Category:All_self-contradictory_articles" title="Category:All self-contradictory articles"><span title="2022 review found no reactivation of TB in nearly 7,000 patients. (April 2024)">contradictory</span></a></i>]</sup> </p> <div class="mw-heading mw-heading2"><h2 id="Adverse_effects">Adverse effects</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Ixekizumab&action=edit&section=3" title="Edit section: Adverse effects"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>In studies, ixekizumab increased the rate of infections (27% of ixekizumab treated patients, compared to 23% under <a href="/wiki/Placebo" title="Placebo">placebo</a>), including severe ones (0.6% versus 0.4% under placebo). Other common side effects included <a href="/wiki/Injection_site_reaction" title="Injection site reaction">injection site reactions</a> such as redness and pain (13–17% versus 3%),<sup id="cite_ref-PMID29462229_16-0" class="reference"><a href="#cite_note-PMID29462229-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Oropharyngeal" class="mw-redirect" title="Oropharyngeal">oropharyngeal</a> pain (1%) and <a href="/wiki/Nausea" title="Nausea">nausea</a> (1–2%).<sup id="cite_ref-AC_10-4" class="reference"><a href="#cite_note-AC-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> Other common adverse effects (≥5.0%) include <a href="/wiki/Nasopharyngitis" class="mw-redirect" title="Nasopharyngitis">nasopharyngitis</a>, <a href="/wiki/Upper_respiratory_tract_infection" title="Upper respiratory tract infection">upper respiratory tract infection</a>, <a href="/wiki/Arthralgia" title="Arthralgia">arthralgia</a>, headache, back pain, <a href="/wiki/Hypertension" title="Hypertension">hypertension</a>, <a href="/wiki/Bronchitis" title="Bronchitis">bronchitis</a>, diarrhea, <a href="/wiki/Sinusitis" title="Sinusitis">sinusitis</a>, and <a href="/wiki/Urinary_tract_infection" title="Urinary tract infection">urinary tract infection</a>.<sup id="cite_ref-Griffiths2022_17-0" class="reference"><a href="#cite_note-Griffiths2022-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> </p><p>In a review of 18,025 patient years (n=6892 patients), no <a href="/wiki/Anaphylaxis" title="Anaphylaxis">anaphylaxis</a> was reported, no reactivation of <a href="/wiki/Tuberculosis" title="Tuberculosis">tuberculosis</a>, and low incidence rate of <a href="/wiki/Candida_infection" class="mw-redirect" title="Candida infection">candida infection</a> and serious infections was found. Incidence rates decreased or remained constant over time.<sup id="cite_ref-Griffiths2022_17-1" class="reference"><a href="#cite_note-Griffiths2022-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> </p><p>Ixekizumab does not have an increased risk of adverse effects in the elderly.<sup id="cite_ref-DiLernia2018_18-0" class="reference"><a href="#cite_note-DiLernia2018-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Overdose">Overdose</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Ixekizumab&action=edit&section=4" title="Edit section: Overdose"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Up to fourfold doses have been given in studies without causing serious side effects.<sup id="cite_ref-AC_10-5" class="reference"><a href="#cite_note-AC-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Interactions">Interactions</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Ixekizumab&action=edit&section=5" title="Edit section: Interactions"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>No interaction studies have been done. Ixekizumab and interleukin 17 are not known to interact with <a href="/wiki/Cytochrome_P450" title="Cytochrome P450">cytochrome P450</a> (CYP) liver enzymes. Since inflammation suppresses CYP activity, it is theorized that ixekizumab could neutralize this effect and lower <a href="/wiki/Blood_plasma" title="Blood plasma">blood plasma</a> concentrations of drugs that are metabolized by CYP enzymes, such as <a href="/wiki/Warfarin" title="Warfarin">warfarin</a>.<sup id="cite_ref-AC_10-6" class="reference"><a href="#cite_note-AC-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Pharmacology">Pharmacology</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Ixekizumab&action=edit&section=6" title="Edit section: Pharmacology"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Mechanism_of_action">Mechanism of action</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Ixekizumab&action=edit&section=7" title="Edit section: Mechanism of action"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Ixekizumab binds to interleukin 17 (IL-17A), a pro-inflammatory <a href="/wiki/Cytokine" title="Cytokine">cytokine</a>, and blocks its action. Among other things, IL-17A stimulates <a href="/wiki/Cell_proliferation" title="Cell proliferation">proliferation</a> and activation of <a href="/wiki/Keratinocyte" title="Keratinocyte">keratinocytes</a> in the skin.<sup id="cite_ref-AC_10-7" class="reference"><a href="#cite_note-AC-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> This mechanism is similar to that of another anti-psoriasis antibody, <a href="/wiki/Brodalumab" title="Brodalumab">brodalumab</a>, which binds to the <a href="/wiki/Interleukin-17_receptor" title="Interleukin-17 receptor">interleukin-17 receptor</a>.<sup id="cite_ref-pharmazeutische-zeitung_19-0" class="reference"><a href="#cite_note-pharmazeutische-zeitung-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> </p><p>The antibody has affinity to the <a href="/wiki/Homodimer" class="mw-redirect" title="Homodimer">homodimer</a> IL-17A and the heterodimer IL-17A/F, but not to other members of the <a href="/wiki/Interleukin_17_family" class="mw-redirect" title="Interleukin 17 family">interleukin 17 family</a>.<sup id="cite_ref-AC_10-8" class="reference"><a href="#cite_note-AC-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Pharmacokinetics">Pharmacokinetics</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Ixekizumab&action=edit&section=8" title="Edit section: Pharmacokinetics"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>After <a href="/wiki/Subcutaneous_injection" class="mw-redirect" title="Subcutaneous injection">subcutaneous injection</a>, ixekizumab has a bioavailability of 60–81%;<sup id="cite_ref-Vu2016_7-1" class="reference"><a href="#cite_note-Vu2016-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> bioavailability is higher in the thigh than the abdomen or arm.<sup id="cite_ref-Vu2016_7-2" class="reference"><a href="#cite_note-Vu2016-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> Highest blood plasma concentrations are reached after four to seven days after a single dose.<sup id="cite_ref-Kiwalkar2019_8-1" class="reference"><a href="#cite_note-Kiwalkar2019-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> With the usual dosing scheme (loading plus a dose every two weeks), steady state concentrations are reached in the eighth week on average.<sup id="cite_ref-AC_10-9" class="reference"><a href="#cite_note-AC-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p><p>Like other <a href="/wiki/Antibodies" class="mw-redirect" title="Antibodies">antibodies</a>, ixekizumab is probably degraded by <a href="/wiki/Proteolysis" title="Proteolysis">proteolysis</a>. Its <a href="/wiki/Elimination_half-life" class="mw-redirect" title="Elimination half-life">elimination half-life</a> is 14–18 days.<sup id="cite_ref-AC_10-10" class="reference"><a href="#cite_note-AC-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-PMID25748485_20-0" class="reference"><a href="#cite_note-PMID25748485-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> The volume of distribution is 7.11 L.<sup id="cite_ref-Kiwalkar2019_8-2" class="reference"><a href="#cite_note-Kiwalkar2019-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> Mean clearance is 0.39 L/day.<sup id="cite_ref-Kiwalkar2019_8-3" class="reference"><a href="#cite_note-Kiwalkar2019-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> There is no difference in rate of clearance between elderly and younger patients.<sup id="cite_ref-DiLernia2018_18-1" class="reference"><a href="#cite_note-DiLernia2018-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> Increased body weight increases the volume of distribution and clearance rate.<sup id="cite_ref-Kiwalkar2019_8-4" class="reference"><a href="#cite_note-Kiwalkar2019-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> Ixekizumab displays linear pharmacokinetics across doses.<sup id="cite_ref-PMID25748485_20-1" class="reference"><a href="#cite_note-PMID25748485-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> </p><p>Pharmacokinetic data is similar for <a href="/wiki/Autoinjector" title="Autoinjector">autoinjector</a> pens and <a href="/wiki/Prefilled_syringe" class="mw-redirect" title="Prefilled syringe">prefilled syringes</a>.<sup id="cite_ref-Vu2016_7-3" class="reference"><a href="#cite_note-Vu2016-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Chemistry">Chemistry</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Ixekizumab&action=edit&section=9" title="Edit section: Chemistry"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Ixekizumab is a complete monoclonal antibody of the subclass <a href="/wiki/Immunoglobulin_G" title="Immunoglobulin G">IgG<sub>4</sub></a>, consisting of two <a href="/wiki/Immunoglobulin_light_chain" title="Immunoglobulin light chain">light chains</a> and two <a href="/wiki/Immunoglobulin_heavy_chain" title="Immunoglobulin heavy chain">heavy chains</a> linked by <a href="/wiki/Disulfide_bridge" class="mw-redirect" title="Disulfide bridge">disulfide bridges</a>. Both heavy chains are <a href="/wiki/Glycosylated" class="mw-redirect" title="Glycosylated">glycosylated</a> at the <a href="/wiki/Asparagine" title="Asparagine">asparagine</a> in position 296. In the hinge region, a <a href="/wiki/Serine" title="Serine">serine</a> is replaced by a <a href="/wiki/Proline" title="Proline">proline</a> to reduce formation of half-antibodies and <a href="/wiki/Heterodimer" class="mw-redirect" title="Heterodimer">heterodimers</a> in the manufacturing process. The terminal <a href="/wiki/Lysine" title="Lysine">lysine</a> found in wild-type IgG<sub>4</sub> is removed. The antibody is produced in <a href="/wiki/Chinese_hamster_ovary_cell" title="Chinese hamster ovary cell">Chinese hamster ovary cells</a>.<sup id="cite_ref-USAN_9-1" class="reference"><a href="#cite_note-USAN-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-21" class="reference"><a href="#cite_note-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="History">History</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Ixekizumab&action=edit&section=10" title="Edit section: History"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/wiki/Clinical_trial" title="Clinical trial">Clinical trials</a> included a <a href="/wiki/Phase_II_clinical_trial" class="mw-redirect" title="Phase II clinical trial">Phase II trial</a> of patients with moderate to severe psoriasis,<sup id="cite_ref-pharmazeutische-zeitung_19-1" class="reference"><a href="#cite_note-pharmazeutische-zeitung-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> and a Phase III <a href="/wiki/Open-label_trial" title="Open-label trial">open-label trial</a>.<sup id="cite_ref-22" class="reference"><a href="#cite_note-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup><sup class="noprint Inline-Template" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citing_sources#What_information_to_include" title="Wikipedia:Citing sources"><span title="A complete citation is needed. (September 2020)">full citation needed</span></a></i>]</sup> </p><p>Ixekizumab was approved by the US <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> (FDA) in March 2016, for the treatment of adults with moderate-to-severe plaque psoriasis<sup id="cite_ref-FDA_PR_20160322_12-1" class="reference"><a href="#cite_note-FDA_PR_20160322-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> and by the <a href="/wiki/European_Medicines_Agency" title="European Medicines Agency">European Medicines Agency</a> (EMA) in April 2016.<sup id="cite_ref-Taltz_EPAR_6-4" class="reference"><a href="#cite_note-Taltz_EPAR-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> The safety and efficacy of ixekizumab were established in three randomized, placebo-controlled clinical trials with a total of 3,866 participants with plaque psoriasis who were candidates for systemic or phototherapy therapy.<sup id="cite_ref-FDA_PR_20160322_12-2" class="reference"><a href="#cite_note-FDA_PR_20160322-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> The FDA approved ixekizumab based on the evidence from three clinical trials of 1958 participants with moderate to severe psoriasis.<sup id="cite_ref-FDA_snapshot_23-0" class="reference"><a href="#cite_note-FDA_snapshot-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> The trials were conducted in the US, Canada, Europe, Russia, Mexico, Chile, Argentina, Japan and Australia.<sup id="cite_ref-FDA_snapshot_23-1" class="reference"><a href="#cite_note-FDA_snapshot-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> </p><p>In December 2017, the FDA approved it for active psoriatic arthritis.<sup id="cite_ref-24" class="reference"><a href="#cite_note-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Ixekizumab&action=edit&section=11" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output 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.id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20180321160723/http://www.pharmacytimes.com/contributor/timothy-o-shea/2018/02/12-difficult-to-pronounce-drug-names-part-2">"12 Difficult-to-Pronounce Drug 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href="/wiki/Template_talk:Immunosuppressants" title="Template talk:Immunosuppressants"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Immunosuppressants" title="Special:EditPage/Template:Immunosuppressants"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Immunosuppressive_drugs_/_Immunosuppressants_(L04)" style="font-size:114%;margin:0 4em"><a href="/wiki/Immunosuppressive_drug" title="Immunosuppressive drug">Immunosuppressive drugs</a> / <a href="/wiki/Immunosuppression" title="Immunosuppression">Immunosuppressants</a> (<a href="/wiki/ATC_code_L04" title="ATC code L04">L04</a>)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Intracellular<br />(initiation)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Antimetabolite" title="Antimetabolite">Antimetabolites</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Purine_synthesis_inhibitor" class="mw-redirect" title="Purine synthesis inhibitor">purine synthesis inhibitors</a></i> <ul><li><a href="/wiki/Azathioprine" title="Azathioprine">Azathioprine</a></li> <li><a href="/wiki/Mycophenolic_acid" title="Mycophenolic acid">Mycophenolic acid</a></li></ul></li></ul> <ul><li><i><a href="/wiki/Dihydroorotate_dehydrogenase" title="Dihydroorotate dehydrogenase">dihydroorotate dehydrogenase</a></i> inhibitors <ul><li><a href="/wiki/Leflunomide" title="Leflunomide">Leflunomide</a></li> <li><a href="/wiki/Teriflunomide" title="Teriflunomide">Teriflunomide</a></li></ul></li></ul> <ul><li><i><a href="/wiki/Antifolate" title="Antifolate">antifolate</a></i> <ul><li><a href="/wiki/Methotrexate" title="Methotrexate">Methotrexate</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Macrolide" title="Macrolide">Macrolides</a>/<br />other <a href="/wiki/Interleukin_2" title="Interleukin 2">IL-2</a> inhibitors</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/FKBP" title="FKBP">FKBP</a>/<a href="/wiki/Cyclophilin" title="Cyclophilin">Cyclophilin</a>/<a href="/wiki/Calcineurin" title="Calcineurin">Calcineurin</a></i> <ul><li><a href="/wiki/Ciclosporin" title="Ciclosporin">Ciclosporin</a></li> <li><a href="/wiki/Pimecrolimus" title="Pimecrolimus">Pimecrolimus</a></li> <li><a href="/wiki/Tacrolimus" title="Tacrolimus">Tacrolimus</a></li> <li><a href="/wiki/Voclosporin" title="Voclosporin">Voclosporin</a></li></ul></li></ul> <ul><li><a href="/wiki/Abetimus" title="Abetimus">Abetimus</a></li> <li><a href="/wiki/Gusperimus" title="Gusperimus">Gusperimus</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Immunomodulatory_imide_drug" class="mw-redirect" title="Immunomodulatory imide drug">IMiDs</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Lenalidomide" title="Lenalidomide">Lenalidomide</a></li> <li><a href="/wiki/Pomalidomide" title="Pomalidomide">Pomalidomide</a></li> <li><a href="/wiki/Thalidomide" title="Thalidomide">Thalidomide</a></li> <li><i><a href="/wiki/PDE4_inhibitor" title="PDE4 inhibitor">PDE4 inhibitor</a></i> <ul><li><a href="/wiki/Apremilast" title="Apremilast">Apremilast</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Intracellular<br />(reception)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Interleukin_1_receptor_antagonist" class="mw-redirect" title="Interleukin 1 receptor antagonist">IL-1 receptor antagonists</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Anakinra" title="Anakinra">Anakinra</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/MTOR" title="MTOR">mTOR</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Everolimus" title="Everolimus">Everolimus</a></li> <li><a href="/wiki/Ridaforolimus" title="Ridaforolimus">Ridaforolimus</a></li> <li><a href="/wiki/Sirolimus" title="Sirolimus">Sirolimus</a></li> <li><a href="/wiki/Temsirolimus" title="Temsirolimus">Temsirolimus</a></li> <li><a href="/wiki/Umirolimus" title="Umirolimus">Umirolimus</a></li> <li><a href="/wiki/Zotarolimus" title="Zotarolimus">Zotarolimus</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Extracellular</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Antibody" title="Antibody">Antibodies</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Monoclonal_antibody" title="Monoclonal antibody">Monoclonal</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Serum target<br />(noncellular)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Complement_component_5" title="Complement component 5">Complement component 5</a></i> <ul><li><a href="/wiki/Eculizumab" title="Eculizumab">Eculizumab</a></li></ul></li></ul> <ul><li><i><a href="/wiki/TNF_inhibitor" title="TNF inhibitor">TNF</a></i> <ul><li><a href="/wiki/Adalimumab" title="Adalimumab">Adalimumab</a></li> <li><a href="/wiki/Afelimomab" title="Afelimomab">Afelimomab</a></li> <li><a href="/wiki/Certolizumab_pegol" title="Certolizumab pegol">Certolizumab pegol</a></li> <li><a href="/wiki/Golimumab" title="Golimumab">Golimumab</a></li> <li><a href="/wiki/Infliximab" title="Infliximab">Infliximab</a></li> <li><a href="/wiki/Nerelimomab" title="Nerelimomab">Nerelimomab</a></li></ul></li></ul> <ul><li><i><a href="/wiki/Interleukin" title="Interleukin">Interleukin</a></i> <ul><li><a href="/wiki/Anakinra" title="Anakinra">Anakinra</a></li> <li><a href="/wiki/Basiliximab" title="Basiliximab">Basiliximab</a></li> <li><a href="/wiki/Bimekizumab" title="Bimekizumab">Bimekizumab</a></li> <li><a href="/wiki/Briakinumab" title="Briakinumab">Briakinumab</a></li> <li><a href="/wiki/Brodalumab" title="Brodalumab">Brodalumab</a></li> <li><a href="/wiki/Canakinumab" title="Canakinumab">Canakinumab</a></li> <li><a href="/wiki/Daclizumab" title="Daclizumab">Daclizumab</a></li> <li><a href="/wiki/Guselkumab" title="Guselkumab">Guselkumab</a></li> <li><a class="mw-selflink selflink">Ixekizumab</a></li> <li><a href="/w/index.php?title=Netakimab&action=edit&redlink=1" class="new" title="Netakimab (page does not exist)">Netakimab</a></li> <li><a href="/wiki/Olokizumab" title="Olokizumab">Olokizumab</a></li> <li><a href="/wiki/Rilonacept" title="Rilonacept">Rilonacept</a></li> <li><a href="/wiki/Risankizumab" title="Risankizumab">Risankizumab</a></li> <li><a href="/wiki/Sarilumab" title="Sarilumab">Sarilumab</a></li> <li><a href="/wiki/Satralizumab" title="Satralizumab">Satralizumab</a></li> <li><a href="/wiki/Secukinumab" title="Secukinumab">Secukinumab</a></li> <li><a href="/wiki/Siltuximab" title="Siltuximab">Siltuximab</a></li> <li><a href="/wiki/Sirukumab" title="Sirukumab">Sirukumab</a></li> <li><a href="/wiki/Spesolimab" title="Spesolimab">Spesolimab</a></li> <li><a href="/wiki/Tildrakizumab" title="Tildrakizumab">Tildrakizumab</a></li> <li><a href="/wiki/Tocilizumab" title="Tocilizumab">Tocilizumab</a></li> <li><a href="/wiki/Ustekinumab" title="Ustekinumab">Ustekinumab</a></li></ul></li></ul> <ul><li><i><a href="/wiki/Interleukin_5" title="Interleukin 5">Interleukin 5</a></i> <ul><li><a href="/wiki/Mepolizumab" title="Mepolizumab">Mepolizumab</a></li></ul></li></ul> <ul><li><i><a href="/wiki/Immunoglobulin_E" title="Immunoglobulin E">Immunoglobulin E</a></i> <ul><li><a href="/wiki/Omalizumab" title="Omalizumab">Omalizumab</a></li></ul></li></ul> <ul><li><i><a href="/wiki/Interferon" title="Interferon">Interferon</a></i> <ul><li><a href="/wiki/Faralimomab" title="Faralimomab">Faralimomab</a></li></ul></li></ul> <ul><li><i><a href="/wiki/Interleukin_6" title="Interleukin 6">IL-6</a></i> <ul><li><a href="/wiki/Elsilimomab" title="Elsilimomab">Elsilimomab</a></li></ul></li></ul> <ul><li><i><a href="/wiki/Interleukin_12" title="Interleukin 12">IL-12</a>, <a href="/wiki/Interleukin_13" title="Interleukin 13">IL-13</a>, and <a href="/wiki/Interleukin_23" title="Interleukin 23">IL-23</a></i> <ul><li><a href="/wiki/Lebrikizumab" title="Lebrikizumab">Lebrikizumab</a></li> <li><a href="/wiki/Ustekinumab" title="Ustekinumab">Ustekinumab</a></li></ul></li></ul> <ul><li><i><a href="/wiki/Interleukin_17" title="Interleukin 17">IL-17A</a></i> <ul><li><a href="/wiki/Secukinumab" title="Secukinumab">Secukinumab</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Cellular<br />target</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/CD3_(immunology)" title="CD3 (immunology)">CD3</a></i> <ul><li><a href="/wiki/Muromonab-CD3" title="Muromonab-CD3">Muromonab-CD3</a></li> <li><a href="/wiki/Otelixizumab" title="Otelixizumab">Otelixizumab</a></li> <li><a href="/wiki/Teplizumab" title="Teplizumab">Teplizumab</a></li> <li><a href="/wiki/Visilizumab" title="Visilizumab">Visilizumab</a></li></ul></li> <li><i><a href="/wiki/CD4" title="CD4">CD4</a></i> <ul><li><a href="/wiki/Clenoliximab" title="Clenoliximab">Clenoliximab</a></li> <li><a href="/wiki/Keliximab" title="Keliximab">Keliximab</a></li> <li><a href="/wiki/Zanolimumab" title="Zanolimumab">Zanolimumab</a></li></ul></li> <li><i><a href="/wiki/CD11a" class="mw-redirect" title="CD11a">CD11a</a></i> <ul><li><a href="/wiki/Efalizumab" title="Efalizumab">Efalizumab</a></li></ul></li> <li><i><a href="/wiki/CD18" class="mw-redirect" title="CD18">CD18</a></i> <ul><li><a href="/wiki/Erlizumab" title="Erlizumab">Erlizumab</a></li></ul></li> <li><i><a href="/wiki/CD20" title="CD20">CD20</a></i> <ul><li><a href="/wiki/Obinutuzumab" title="Obinutuzumab">Obinutuzumab</a></li> <li><a href="/wiki/Ocrelizumab" title="Ocrelizumab">Ocrelizumab</a> (<a href="/wiki/Ocrelizumab/hyaluronidase" title="Ocrelizumab/hyaluronidase">+hyaluronidase</a>)</li> <li><a href="/wiki/Pascolizumab" title="Pascolizumab">Pascolizumab</a></li> <li><a href="/wiki/Rituximab" title="Rituximab">Rituximab</a></li> <li><a href="/wiki/Ublituximab" title="Ublituximab">Ublituximab</a></li></ul></li> <li><i><a href="/wiki/CD23" title="CD23">CD23</a></i> <ul><li><a href="/wiki/Gomiliximab" class="mw-redirect" title="Gomiliximab">Gomiliximab</a></li> <li><a href="/wiki/Lumiliximab" title="Lumiliximab">Lumiliximab</a></li></ul></li> <li><i><a href="/wiki/CD40_(protein)" title="CD40 (protein)">CD40</a></i> <ul><li><a href="/wiki/Teneliximab" title="Teneliximab">Teneliximab</a></li> <li><a href="/wiki/Toralizumab" title="Toralizumab">Toralizumab</a></li></ul></li> <li><i><a href="/wiki/L-selectin" title="L-selectin">CD62L/L-selectin</a></i> <ul><li><a href="/wiki/Aselizumab" title="Aselizumab">Aselizumab</a></li></ul></li> <li><i><a href="/wiki/CD80" title="CD80">CD80</a></i> <ul><li><a href="/wiki/Galiximab" title="Galiximab">Galiximab</a></li></ul></li> <li><i><a href="/wiki/Basigin" title="Basigin">CD147/Basigin</a></i> <ul><li><a href="/wiki/Gavilimomab" title="Gavilimomab">Gavilimomab</a></li></ul></li> <li><i><a href="/wiki/CD154" title="CD154">CD154</a></i> <ul><li><a href="/wiki/Frexalimab" title="Frexalimab">Frexalimab</a></li> <li><a href="/wiki/Ruplizumab" title="Ruplizumab">Ruplizumab</a></li></ul></li></ul> <ul><li><i>BLyS</i> <ul><li><a href="/wiki/Belimumab" title="Belimumab">Belimumab</a></li></ul></li> <li><i><a href="/wiki/Chloramphenicol_acetyltransferase" title="Chloramphenicol acetyltransferase">CAT</a></i> <ul><li><a href="/wiki/Bertilimumab" title="Bertilimumab">Bertilimumab</a></li> <li><a href="/wiki/Lerdelimumab" title="Lerdelimumab">Lerdelimumab</a></li> <li><a href="/wiki/Metelimumab" title="Metelimumab">Metelimumab</a></li></ul></li> <li><i><a href="/wiki/Integrin" title="Integrin">Integrin</a></i> <ul><li><a href="/wiki/Natalizumab" title="Natalizumab">Natalizumab</a></li> <li><a href="/wiki/Vedolizumab" title="Vedolizumab">Vedolizumab</a></li></ul></li> <li><i><a href="/wiki/Interleukin-6_receptor" title="Interleukin-6 receptor">Interleukin-6 receptor</a></i> <ul><li><a href="/wiki/Tocilizumab" title="Tocilizumab">Tocilizumab</a></li></ul></li> <li><i><a href="/wiki/Lymphocyte_function-associated_antigen_1" title="Lymphocyte function-associated antigen 1">LFA-1</a></i> <ul><li><a href="/wiki/Odulimomab" title="Odulimomab">Odulimomab</a></li></ul></li></ul> <ul><li><i><a href="/wiki/IL-2_receptor" title="IL-2 receptor">IL-2 receptor/CD25</a></i> <ul><li><a href="/wiki/Basiliximab" title="Basiliximab">Basiliximab</a></li> <li><a href="/wiki/Daclizumab" title="Daclizumab">Daclizumab</a></li> <li><a href="/wiki/Inolimomab" title="Inolimomab">Inolimomab</a></li></ul></li></ul> <ul><li><i><a href="/wiki/T_cell" title="T cell">T-lymphocyte</a></i> (<a href="/wiki/Zolimomab_aritox" title="Zolimomab aritox">Zolimomab aritox</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Unsorted</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Alemtuzumab" title="Alemtuzumab">Alemtuzumab</a></li> <li><a href="/wiki/Anifrolumab" title="Anifrolumab">Anifrolumab</a></li> <li><a href="/wiki/Atorolimumab" title="Atorolimumab">Atorolimumab</a></li> <li><a href="/w/index.php?title=Begelomab&action=edit&redlink=1" class="new" title="Begelomab (page does not exist)">Begelomab</a></li> <li><a href="/wiki/Cedelizumab" title="Cedelizumab">Cedelizumab</a></li> <li><a href="/wiki/Emapalumab" title="Emapalumab">Emapalumab</a></li> <li><a href="/wiki/Fontolizumab" title="Fontolizumab">Fontolizumab</a></li> <li><a href="/wiki/Inebilizumab" title="Inebilizumab">Inebilizumab</a></li> <li><a href="/wiki/Maslimomab" title="Maslimomab">Maslimomab</a></li> <li><a href="/wiki/Morolimumab" title="Morolimumab">Morolimumab</a></li> <li><a href="/wiki/Ofatumumab" title="Ofatumumab">Ofatumumab</a></li> <li><a href="/wiki/Pexelizumab" title="Pexelizumab">Pexelizumab</a></li> <li><a href="/wiki/Reslizumab" title="Reslizumab">Reslizumab</a></li> <li><a href="/wiki/Rovelizumab" title="Rovelizumab">Rovelizumab</a></li> <li><a href="/wiki/Siplizumab" title="Siplizumab">Siplizumab</a></li> <li><a href="/wiki/Talizumab" title="Talizumab">Talizumab</a></li> <li><a href="/wiki/Telimomab_aritox" title="Telimomab aritox">Telimomab aritox</a></li> <li><a href="/wiki/Teprotumumab" title="Teprotumumab">Teprotumumab</a></li> <li><a href="/wiki/Vapaliximab" title="Vapaliximab">Vapaliximab</a></li> <li><a href="/wiki/Vepalimomab" title="Vepalimomab">Vepalimomab</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Polyclonal_antibodies" title="Polyclonal antibodies">Polyclonal</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Anti-thymocyte_globulin" title="Anti-thymocyte globulin">Anti-thymocyte globulin</a></li> <li><a href="/wiki/Anti-lymphocyte_globulin" title="Anti-lymphocyte globulin">Anti-lymphocyte globulin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">-cept (<a href="/wiki/Fusion_protein" title="Fusion protein">Fusion</a>)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/CTLA-4" class="mw-redirect" title="CTLA-4">CTLA-4</a></i> <ul><li><a href="/wiki/Abatacept" title="Abatacept">Abatacept</a></li> <li><a href="/wiki/Belatacept" title="Belatacept">Belatacept</a></li></ul></li> <li><i><a href="/wiki/TNF_inhibitor" title="TNF inhibitor">TNF inhibitor</a></i> <ul><li><a href="/wiki/Etanercept" title="Etanercept">Etanercept</a></li> <li><a href="/w/index.php?title=Opinercept&action=edit&redlink=1" class="new" title="Opinercept (page does not exist)">Opinercept</a></li></ul></li> <li><a href="/wiki/Aflibercept" title="Aflibercept">Aflibercept</a></li> <li><a href="/wiki/Alefacept" title="Alefacept">Alefacept</a></li> <li><a href="/wiki/Rilonacept" title="Rilonacept">Rilonacept</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Unsorted</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Avacopan" title="Avacopan">Avacopan</a></li> <li><a href="/wiki/Baricitinib" title="Baricitinib">Baricitinib</a></li> <li><a href="/wiki/Bimekizumab" title="Bimekizumab">Bimekizumab</a></li> <li><a href="/wiki/Blisibimod" title="Blisibimod">Blisibimod</a></li> <li><a href="/wiki/Briakinumab" title="Briakinumab">Briakinumab</a></li> <li><a href="/wiki/Brodalumab" title="Brodalumab">Brodalumab</a></li> <li><a href="/wiki/Canakinumab" title="Canakinumab">Canakinumab</a></li> <li><a href="/wiki/Crovalimab" title="Crovalimab">Crovalimab</a></li> <li><a href="/wiki/Danicopan" title="Danicopan">Danicopan</a></li> <li><a href="/wiki/Darvadstrocel" title="Darvadstrocel">Darvadstrocel</a></li> <li><a href="/wiki/Deucravacitinib" title="Deucravacitinib">Deucravacitinib</a></li> <li><a href="/wiki/Deuruxolitinib" title="Deuruxolitinib">Deuruxolitinib</a></li> <li><a href="/wiki/Dimethyl_fumarate" title="Dimethyl fumarate">Dimethyl fumarate</a></li> <li><a href="/wiki/Diroximel_fumarate" title="Diroximel fumarate">Diroximel fumarate</a></li> <li><a href="/wiki/Efgartigimod_alfa" title="Efgartigimod alfa">Efgartigimod alfa</a> (<a href="/wiki/Efgartigimod_alfa/hyaluronidase" title="Efgartigimod alfa/hyaluronidase">+hyaluronidase</a>)</li> <li><a href="/wiki/Etrasimod" title="Etrasimod">Etrasimod</a></li> <li><a href="/wiki/Filgotinib" title="Filgotinib">Filgotinib</a></li> <li><a href="/wiki/Fingolimod" title="Fingolimod">Fingolimod</a></li> <li><a href="/wiki/Guselkumab" title="Guselkumab">Guselkumab</a></li> <li><a href="/wiki/Iptacopan" title="Iptacopan">Iptacopan</a></li> <li><a href="/w/index.php?title=Itacitinib&action=edit&redlink=1" class="new" title="Itacitinib (page does not exist)">Itacitinib</a></li> <li><a class="mw-selflink selflink">Ixekizumab</a></li> <li><a href="/w/index.php?title=Netakimab&action=edit&redlink=1" class="new" title="Netakimab (page does not exist)">Netakimab</a></li> <li><a href="/wiki/Olokizumab" title="Olokizumab">Olokizumab</a></li> <li><a href="/wiki/Ozanimod" title="Ozanimod">Ozanimod</a></li> <li><a href="/wiki/Peficitinib" title="Peficitinib">Peficitinib</a></li> <li><a href="/wiki/Pegcetacoplan" title="Pegcetacoplan">Pegcetacoplan</a></li> <li><a href="/wiki/Pirfenidone" title="Pirfenidone">Pirfenidone</a></li> <li><a href="/wiki/Ponesimod" title="Ponesimod">Ponesimod</a></li> <li><a href="/wiki/Ravulizumab" title="Ravulizumab">Ravulizumab</a></li> <li><a href="/wiki/Risankizumab" title="Risankizumab">Risankizumab</a></li> <li><a href="/wiki/Ritlecitinib" title="Ritlecitinib">Ritlecitinib</a></li> <li><a href="/wiki/Rozanolixizumab" title="Rozanolixizumab">Rozanolixizumab</a></li> <li><a href="/wiki/Sarilumab" title="Sarilumab">Sarilumab</a></li> <li><a href="/wiki/Satralizumab" title="Satralizumab">Satralizumab</a></li> <li><a href="/wiki/Siltuximab" title="Siltuximab">Siltuximab</a></li> <li><a href="/wiki/Siponimod" title="Siponimod">Siponimod</a></li> <li><a href="/wiki/Sirukumab" title="Sirukumab">Sirukumab</a></li> <li><a href="/wiki/Spesolimab" title="Spesolimab">Spesolimab</a></li> <li><a href="/wiki/Sutimlimab" title="Sutimlimab">Sutimlimab</a></li> <li><a href="/wiki/Telitacicept" title="Telitacicept">Telitacicept</a></li> <li><a href="/wiki/Tildrakizumab" title="Tildrakizumab">Tildrakizumab</a></li> <li><a href="/wiki/Tofacitinib" title="Tofacitinib">Tofacitinib</a></li> <li><a href="/wiki/Upadacitinib" title="Upadacitinib">Upadacitinib</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"></div><div role="navigation" class="navbox" aria-labelledby="Monoclonal_antibodies_for_the_immune_system" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="text-align:center;"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Monoclonals_for_immune_system" title="Template:Monoclonals for immune system"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Monoclonals_for_immune_system" title="Template talk:Monoclonals for immune system"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Monoclonals_for_immune_system" title="Special:EditPage/Template:Monoclonals for immune system"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Monoclonal_antibodies_for_the_immune_system" style="font-size:114%;margin:0 4em"><a href="/wiki/Monoclonal_antibodies" class="mw-redirect" title="Monoclonal antibodies">Monoclonal antibodies</a> for the <a href="/wiki/Immune_system" title="Immune system">immune system</a></div></th></tr><tr><th scope="row" class="navbox-group" style="text-align:center;;width:1%"><a href="/wiki/Immune_system" title="Immune system">Immune system</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Human</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Immunosuppression" title="Immunosuppression">Immunosuppression</a></i>: <a href="/wiki/Abrilumab" title="Abrilumab">Abrilumab</a></li> <li><a href="/wiki/Adalimumab" title="Adalimumab">Adalimumab</a><sup>#</sup></li> <li><a href="/wiki/Anifrolumab" title="Anifrolumab">Anifrolumab</a></li> <li><a href="/wiki/Atorolimumab" title="Atorolimumab">Atorolimumab</a></li> <li><a href="/wiki/Avelumab" title="Avelumab">Avelumab</a></li> <li><a href="/w/index.php?title=Avdoralimab&action=edit&redlink=1" class="new" title="Avdoralimab (page does not exist)">Avdoralimab</a></li> <li><a href="/wiki/Belimumab" title="Belimumab">Belimumab</a></li> <li><a href="/wiki/Bleselumab" title="Bleselumab">Bleselumab</a></li> <li><a href="/wiki/Brodalumab" title="Brodalumab">Brodalumab</a></li> <li><a href="/wiki/Camidanlumab_tesirine" title="Camidanlumab tesirine">Camidanlumab tesirine</a></li> <li><a href="/wiki/Carlumab" title="Carlumab">Carlumab</a></li> <li><a href="/wiki/Cemiplimab" title="Cemiplimab">Cemiplimab</a></li> <li><a href="/wiki/Dupilumab" title="Dupilumab">Dupilumab</a></li> <li><a href="/wiki/Eldelumab" title="Eldelumab">Eldelumab</a></li> <li><a href="/wiki/Emapalumab" title="Emapalumab">Emapalumab</a></li> <li><a href="/wiki/Fresolimumab" title="Fresolimumab">Fresolimumab</a></li> <li><a href="/wiki/Golimumab" title="Golimumab">Golimumab</a></li> <li><a href="/wiki/Ianalumab" title="Ianalumab">Ianalumab</a><sup>†</sup></li> <li><a href="/wiki/Lanadelumab" title="Lanadelumab">Lanadelumab</a></li> <li><a href="/wiki/Lenzilumab" title="Lenzilumab">Lenzilumab</a></li> <li><a href="/wiki/Lerdelimumab" title="Lerdelimumab">Lerdelimumab</a></li> <li><a href="/wiki/Lirentelimab" title="Lirentelimab">Lirentelimab</a></li> <li><a href="/wiki/Lirilumab" title="Lirilumab">Lirilumab</a></li> <li><a href="/wiki/Mavrilimumab" title="Mavrilimumab">Mavrilimumab</a></li> <li><a href="/wiki/Metelimumab" title="Metelimumab">Metelimumab</a></li> <li><a href="/wiki/Morolimumab" title="Morolimumab">Morolimumab</a></li> <li><a href="/wiki/Namilumab" title="Namilumab">Namilumab</a></li> <li><a href="/wiki/Oleclumab" title="Oleclumab">Oleclumab</a></li> <li><a href="/wiki/Oxelumab" title="Oxelumab">Oxelumab</a>§</li> <li><a href="/wiki/Pamrevlumab" title="Pamrevlumab">Pamrevlumab</a></li> <li><a href="/wiki/Placulumab" title="Placulumab">Placulumab</a></li> <li><a href="/wiki/Relatlimab" title="Relatlimab">Relatlimab</a><sup>†</sup></li> <li><a href="/wiki/Sarilumab" title="Sarilumab">Sarilumab</a></li> <li><a href="/wiki/Sifalimumab" title="Sifalimumab">Sifalimumab</a></li> <li><a href="/wiki/Tabalumab" title="Tabalumab">Tabalumab</a></li> <li><a href="/wiki/Tezepelumab" title="Tezepelumab">Tezepelumab</a></li> <li><a href="/wiki/Ulocuplumab" title="Ulocuplumab">Ulocuplumab</a></li> <li><a href="/wiki/Varlilumab" title="Varlilumab">Varlilumab</a></li></ul> <ul><li><i>Immune activation</i>: <a href="/wiki/Ipilimumab" title="Ipilimumab">Ipilimumab</a></li> <li><a href="/wiki/Durvalumab" title="Durvalumab">Durvalumab</a></li> <li><a href="/wiki/Nivolumab" title="Nivolumab">Nivolumab</a></li> <li><a href="/wiki/Tremelimumab" title="Tremelimumab">Tremelimumab</a></li> <li><a href="/wiki/Urelumab" title="Urelumab">Urelumab</a></li></ul> <ul><li><i>Other</i>: <a href="/wiki/Bertilimumab" title="Bertilimumab">Bertilimumab</a></li> <li><a href="/w/index.php?title=Ontamalimab&action=edit&redlink=1" class="new" title="Ontamalimab (page does not exist)">Ontamalimab</a></li> <li><a href="/wiki/Zanolimumab" title="Zanolimumab">Zanolimumab</a></li></ul> <ul><li><i>Combination</i>: <a href="/wiki/Nivolumab/relatlimab" title="Nivolumab/relatlimab">Nivolumab/relatlimab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Mouse</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Afelimomab" title="Afelimomab">Afelimomab</a></li> <li><a href="/wiki/Elsilimomab" title="Elsilimomab">Elsilimomab</a></li> <li><a href="/wiki/Faralimomab" title="Faralimomab">Faralimomab</a></li> <li><a href="/wiki/Gavilimomab" title="Gavilimomab">Gavilimomab</a></li> <li><a href="/wiki/Inolimomab" title="Inolimomab">Inolimomab</a></li> <li><a href="/wiki/Maslimomab" title="Maslimomab">Maslimomab</a></li> <li><a href="/wiki/Nerelimomab" title="Nerelimomab">Nerelimomab</a></li> <li><a href="/wiki/Odulimomab" title="Odulimomab">Odulimomab</a></li> <li><a href="/wiki/Telimomab_aritox" title="Telimomab aritox">Telimomab aritox</a></li> <li><a href="/wiki/Vepalimomab" title="Vepalimomab">Vepalimomab</a></li> <li><a href="/wiki/Zolimomab_aritox" title="Zolimomab aritox">Zolimomab aritox</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Chimeric_antibody" class="mw-redirect" title="Chimeric antibody">Chimeric</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Andecaliximab" title="Andecaliximab">Andecaliximab</a><sup>†</sup></li> <li><a href="/wiki/Basiliximab" title="Basiliximab">Basiliximab</a></li> <li><a href="/wiki/Clenoliximab" title="Clenoliximab">Clenoliximab</a></li> <li><a href="/wiki/Galiximab" title="Galiximab">Galiximab</a></li> <li><a href="/wiki/Gomiliximab" class="mw-redirect" title="Gomiliximab">Gomiliximab</a></li> <li><a href="/wiki/Infliximab" title="Infliximab">Infliximab</a></li> <li><a href="/wiki/Keliximab" title="Keliximab">Keliximab</a></li> <li><a href="/wiki/Lumiliximab" title="Lumiliximab">Lumiliximab</a></li> <li><a href="/wiki/Priliximab" title="Priliximab">Priliximab</a></li> <li><a href="/wiki/Teneliximab" title="Teneliximab">Teneliximab</a></li> <li><a href="/wiki/Vapaliximab" title="Vapaliximab">Vapaliximab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Humanized_antibody" title="Humanized antibody">Humanized</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Immunosuppressive:</i> <a href="/wiki/Apolizumab" title="Apolizumab">Apolizumab</a><sup>§</sup></li> <li><a href="/wiki/Aselizumab" title="Aselizumab">Aselizumab</a></li> <li><a href="/wiki/Atezolizumab" title="Atezolizumab">Atezolizumab</a></li> <li><a href="/wiki/Benralizumab" title="Benralizumab">Benralizumab</a></li> <li><a href="/wiki/Camrelizumab" title="Camrelizumab">Camrelizumab</a><sup>†</sup></li> <li><a href="/wiki/Cedelizumab" title="Cedelizumab">Cedelizumab</a></li> <li><a href="/wiki/Certolizumab_pegol" title="Certolizumab pegol">Certolizumab pegol</a></li> <li><a href="/wiki/Crizanlizumab" title="Crizanlizumab">Crizanlizumab</a></li> <li><a href="/wiki/Daclizumab" title="Daclizumab">Daclizumab</a></li> <li><a href="/wiki/Eculizumab" title="Eculizumab">Eculizumab</a></li> <li><a href="/wiki/Efalizumab" title="Efalizumab">Efalizumab</a><sup>‡</sup></li> <li><a href="/wiki/Epratuzumab" title="Epratuzumab">Epratuzumab</a></li> <li><a href="/wiki/Erlizumab" title="Erlizumab">Erlizumab</a></li> <li><a href="/wiki/Etrolizumab" title="Etrolizumab">Etrolizumab</a><sup>†</sup></li> <li><a href="/wiki/Fontolizumab" title="Fontolizumab">Fontolizumab</a></li> <li><a href="/wiki/Frexalimab" title="Frexalimab">Frexalimab</a><sup>†</sup></li> <li><a href="/wiki/Inebilizumab" title="Inebilizumab">Inebilizumab</a></li> <li><a href="/wiki/Itolizumab" title="Itolizumab">Itolizumab</a></li> <li><a href="/wiki/Lampalizumab" title="Lampalizumab">Lampalizumab</a><sup>†</sup></li> <li><a href="/wiki/Letolizumab" title="Letolizumab">Letolizumab</a></li> <li><a href="/wiki/Ligelizumab" title="Ligelizumab">Ligelizumab</a><sup>†</sup></li> <li><a href="/wiki/Lulizumab_pegol" title="Lulizumab pegol">Lulizumab pegol</a></li> <li><a href="/wiki/Mepolizumab" title="Mepolizumab">Mepolizumab</a></li> <li><a href="/wiki/Mogamulizumab" title="Mogamulizumab">Mogamulizumab</a></li> <li><a href="/wiki/Natalizumab" title="Natalizumab">Natalizumab</a></li> <li><a href="/wiki/Ocrelizumab" title="Ocrelizumab">Ocrelizumab</a> (<a href="/wiki/Ocrelizumab/hyaluronidase" title="Ocrelizumab/hyaluronidase">+hyaluronidase</a>)</li> <li><a href="/wiki/Omalizumab" title="Omalizumab">Omalizumab</a></li> <li><a href="/wiki/Ozoralizumab" title="Ozoralizumab">Ozoralizumab</a></li> <li><a href="/wiki/Pascolizumab" title="Pascolizumab">Pascolizumab</a></li> <li><a href="/wiki/Pateclizumab" title="Pateclizumab">Pateclizumab</a></li> <li><a href="/wiki/Pembrolizumab" title="Pembrolizumab">Pembrolizumab</a></li> <li><a href="/wiki/Pexelizumab" title="Pexelizumab">Pexelizumab</a></li> <li><a href="/wiki/Pidilizumab" title="Pidilizumab">Pidilizumab</a></li> <li><a href="/wiki/Plozalizumab" title="Plozalizumab">Plozalizumab</a></li> <li><a href="/wiki/PRO_140" class="mw-redirect" title="PRO 140">PRO 140</a><sup>†</sup></li> <li><a href="/wiki/Quilizumab" title="Quilizumab">Quilizumab</a></li> <li><a href="/wiki/Ravulizumab" title="Ravulizumab">Ravulizumab</a></li> <li><a href="/wiki/Reslizumab" title="Reslizumab">Reslizumab</a></li> <li><a href="/wiki/Retifanlimab" title="Retifanlimab">Retifanlimab</a></li> <li><a href="/wiki/Rontalizumab" title="Rontalizumab">Rontalizumab</a></li> <li><a href="/wiki/Rovelizumab" title="Rovelizumab">Rovelizumab</a></li> <li><a href="/wiki/Ruplizumab" title="Ruplizumab">Ruplizumab</a></li> <li><a href="/wiki/Samalizumab" title="Samalizumab">Samalizumab</a></li> <li><a href="/wiki/Satralizumab" title="Satralizumab">Satralizumab</a></li> <li><a href="/wiki/Siplizumab" title="Siplizumab">Siplizumab</a></li> <li><a href="/wiki/Spartalizumab" title="Spartalizumab">Spartalizumab</a><sup>†</sup></li> <li><a href="/wiki/Talizumab" title="Talizumab">Talizumab</a></li> <li><a href="/wiki/Teclistamab" title="Teclistamab">Teclistamab</a></li> <li><a href="/wiki/Teplizumab" title="Teplizumab">Teplizumab</a></li> <li><a href="/wiki/Tislelizumab" title="Tislelizumab">Tislelizumab</a></li> <li><a href="/wiki/Tocilizumab" title="Tocilizumab">Tocilizumab</a></li> <li><a href="/wiki/Toralizumab" title="Toralizumab">Toralizumab</a></li> <li><a href="/wiki/Tregalizumab" title="Tregalizumab">Tregalizumab</a></li> <li><a href="/wiki/Vatelizumab" title="Vatelizumab">Vatelizumab</a></li> <li><a href="/wiki/Vedolizumab" title="Vedolizumab">Vedolizumab</a></li> <li><a href="/wiki/Visilizumab" title="Visilizumab">Visilizumab</a></li> <li><a href="/wiki/Vobarilizumab" title="Vobarilizumab">Vobarilizumab</a></li> <li><a href="/wiki/TGN1412" class="mw-redirect" title="TGN1412">TGN1412</a><sup>§</sup><br /></li></ul> <p><i>Immune activation</i>: <a href="/wiki/Dostarlimab" title="Dostarlimab">Dostarlimab</a><br /> <i>Other:</i> <a href="/wiki/Ibalizumab" title="Ibalizumab">Ibalizumab</a> </p> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Chimeric + humanized<br /></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Otelixizumab" title="Otelixizumab">Otelixizumab</a></li> <li><a href="/wiki/Rozanolixizumab" title="Rozanolixizumab">Rozanolixizumab</a></li> <li><a href="/wiki/Sutimlimab" title="Sutimlimab">Sutimlimab</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="text-align:center;;width:1%"><a href="/wiki/Interleukin" title="Interleukin">Interleukin</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Human</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Bermekimab" title="Bermekimab">Bermekimab</a></li> <li><a href="/wiki/Brazikumab" title="Brazikumab">Brazikumab</a></li> <li><a href="/wiki/Briakinumab" title="Briakinumab">Briakinumab</a></li> <li><a href="/wiki/Canakinumab" title="Canakinumab">Canakinumab</a></li> <li><a href="/wiki/Fezakinumab" title="Fezakinumab">Fezakinumab</a></li> <li><a href="/wiki/Fletikumab" title="Fletikumab">Fletikumab</a></li> <li><a href="/wiki/Guselkumab" title="Guselkumab">Guselkumab</a></li> <li><a href="/wiki/Secukinumab" title="Secukinumab">Secukinumab</a></li> <li><a href="/wiki/Sirukumab" title="Sirukumab">Sirukumab</a></li> <li><a href="/wiki/Tralokinumab" title="Tralokinumab">Tralokinumab</a></li> <li><a href="/wiki/Ustekinumab" title="Ustekinumab">Ustekinumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Humanized</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Anrukinzumab" title="Anrukinzumab">Anrukinzumab</a></li> <li><a href="/wiki/Bimekizumab" title="Bimekizumab">Bimekizumab</a></li> <li><a href="/wiki/Clazakizumab" title="Clazakizumab">Clazakizumab</a></li> <li><a href="/wiki/Gevokizumab" title="Gevokizumab">Gevokizumab</a></li> <li><a class="mw-selflink selflink">Ixekizumab</a></li> <li><a href="/wiki/Mirikizumab" title="Mirikizumab">Mirikizumab</a><sup>†</sup></li> <li><a href="/wiki/Lebrikizumab" title="Lebrikizumab">Lebrikizumab</a></li> <li><a href="/wiki/Olokizumab" title="Olokizumab">Olokizumab</a><sup>†</sup></li> <li><a href="/wiki/Perakizumab" title="Perakizumab">Perakizumab</a></li> <li><a href="/wiki/Risankizumab" title="Risankizumab">Risankizumab</a></li> <li><a href="/wiki/Spesolimab" title="Spesolimab">Spesolimab</a></li> <li><a href="/wiki/Tildrakizumab" title="Tildrakizumab">Tildrakizumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Veterinary</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Lokivetmab" title="Lokivetmab">Lokivetmab</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="text-align:center;;width:1%">Inflammatory <a href="/wiki/Lesion" title="Lesion">lesions</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="Mouse" scope="row" class="navbox-group" style="width:1%;text-align:center;">Mouse</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Besilesomab" title="Besilesomab">Besilesomab</a></li> <li><a href="/wiki/Technetium_(99mTc)_fanolesomab" title="Technetium (99mTc) fanolesomab">Fanolesomab</a><sup>‡</sup></li> <li><a href="/wiki/Lemalesomab" title="Lemalesomab">Lemalesomab</a></li> <li><a href="/wiki/Technetium_(99mTc)_sulesomab" title="Technetium (99mTc) sulesomab">Sulesomab</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><td class="navbox-abovebelow" colspan="2" style="text-align:center;;background: transparent; padding: 0px;"><div><div class="hlist"> <ul><li><sup>#</sup><a href="/wiki/WHO_Model_List_of_Essential_Medicines" title="WHO Model List of Essential Medicines">WHO-EM</a></li> <li><sup>‡</sup><a href="/wiki/List_of_withdrawn_drugs" title="List of withdrawn drugs">Withdrawn</a> from market</li> <li><a href="/wiki/Clinical_trial" title="Clinical trial">Clinical trials</a>: <ul><li><sup>†</sup><a href="/wiki/Phases_of_clinical_research#Phase_III" title="Phases of clinical research">Phase III</a></li> <li><sup>§</sup>Never to phase III</li></ul></li></ul> </div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Interleukin_receptor_modulators" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Interleukin_receptor_modulators" title="Template:Interleukin receptor modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Interleukin_receptor_modulators" title="Template talk:Interleukin receptor modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Interleukin_receptor_modulators" title="Special:EditPage/Template:Interleukin receptor modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Interleukin_receptor_modulators" style="font-size:114%;margin:0 4em"><a href="/wiki/Interleukin_receptor" title="Interleukin receptor">Interleukin receptor</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-1_receptor" title="Interleukin-1 receptor">IL-1</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_1" class="mw-redirect" title="Interleukin 1">Interleukin 1</a> (<a href="/wiki/Interleukin_1_alpha" class="mw-redirect" title="Interleukin 1 alpha">α</a>, <a href="/wiki/Interleukin_1_beta" title="Interleukin 1 beta">β</a>)</li> <li><a href="/w/index.php?title=Mobenakin&action=edit&redlink=1" class="new" title="Mobenakin (page does not exist)">Mobenakin</a></li> <li><a href="/w/index.php?title=Pifonakin&action=edit&redlink=1" class="new" title="Pifonakin (page does not exist)">Pifonakin</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/w/index.php?title=AF-12198&action=edit&redlink=1" class="new" title="AF-12198 (page does not exist)">AF-12198</a></li> <li><a href="/wiki/Anakinra" title="Anakinra">Anakinra</a></li> <li><a href="/wiki/Interleukin_1_receptor_antagonist" class="mw-redirect" title="Interleukin 1 receptor antagonist">IL-1RA</a></li> <li><a href="/w/index.php?title=Isunakinra&action=edit&redlink=1" class="new" title="Isunakinra (page does not exist)">Isunakinra</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Canakinumab" title="Canakinumab">Canakinumab</a></li> <li><a href="/wiki/Gevokizumab" title="Gevokizumab">Gevokizumab</a></li> <li><a href="/w/index.php?title=Lutikizumab&action=edit&redlink=1" class="new" title="Lutikizumab (page does not exist)">Lutikizumab</a></li></ul> <ul><li><i>Decoy receptors:</i> <a href="/wiki/Rilonacept" title="Rilonacept">Rilonacept (IL-1 Trap)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-2_receptor" class="mw-redirect" title="Interleukin-2 receptor">IL-2</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Adargileukin_alfa&action=edit&redlink=1" class="new" title="Adargileukin alfa (page does not exist)">Adargileukin alfa</a></li> <li><a href="/wiki/Aldesleukin" class="mw-redirect" title="Aldesleukin">Aldesleukin</a></li> <li><a href="/w/index.php?title=Celmoleukin&action=edit&redlink=1" class="new" title="Celmoleukin (page does not exist)">Celmoleukin</a></li> <li><a href="/wiki/Denileukin_diftitox" title="Denileukin diftitox">Denileukin diftitox</a></li> <li><a href="/wiki/Interleukin_2" title="Interleukin 2">Interleukin 2</a></li> <li><a href="/w/index.php?title=Pegaldesleukin&action=edit&redlink=1" class="new" title="Pegaldesleukin (page does not exist)">Pegaldesleukin</a></li> <li><a href="/w/index.php?title=Teceleukin&action=edit&redlink=1" class="new" title="Teceleukin (page does not exist)">Teceleukin</a></li> <li><a href="/wiki/Tucotuzumab_celmoleukin" title="Tucotuzumab celmoleukin">Tucotuzumab celmoleukin</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Basiliximab" title="Basiliximab">Basiliximab</a></li> <li><a href="/wiki/Daclizumab" title="Daclizumab">Daclizumab (dacliximab)</a></li> <li><a href="/wiki/Inolimomab" title="Inolimomab">Inolimomab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-3_receptor" title="Interleukin-3 receptor">IL-3</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Daniplestim&action=edit&redlink=1" class="new" title="Daniplestim (page does not exist)">Daniplestim</a></li> <li><a href="/wiki/Interleukin_3" title="Interleukin 3">Interleukin 3</a></li> <li><a href="/w/index.php?title=Leridistim&action=edit&redlink=1" class="new" title="Leridistim (page does not exist)">Leridistim</a></li> <li><a href="/w/index.php?title=Milodistim&action=edit&redlink=1" class="new" title="Milodistim (page does not exist)">Milodistim</a></li> <li><a href="/w/index.php?title=Muplestim&action=edit&redlink=1" class="new" title="Muplestim (page does not exist)">Muplestim</a></li> <li><a href="/wiki/Promegapoietin" title="Promegapoietin">Promegapoietin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-4_receptor" title="Interleukin-4 receptor">IL-4</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Binetrakin&action=edit&redlink=1" class="new" title="Binetrakin (page does not exist)">Binetrakin</a></li> <li><a href="/wiki/Interleukin_4" title="Interleukin 4">Interleukin 4</a></li> <li><a href="/wiki/Interleukin_13" title="Interleukin 13">Interleukin 13</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/wiki/Pitrakinra" title="Pitrakinra">Pitrakinra</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Dupilumab" title="Dupilumab">Dupilumab</a></li> <li><a href="/wiki/Pascolizumab" title="Pascolizumab">Pascolizumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-5_receptor" title="Interleukin-5 receptor">IL-5</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_5" title="Interleukin 5">Interleukin 5</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/w/index.php?title=YM-90709&action=edit&redlink=1" class="new" title="YM-90709 (page does not exist)">YM-90709</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Benralizumab" title="Benralizumab">Benralizumab</a></li> <li><a href="/wiki/Mepolizumab" title="Mepolizumab">Mepolizumab</a></li> <li><a href="/wiki/Reslizumab" title="Reslizumab">Reslizumab</a></li></ul> <ul><li><i>Antisense oligonucleotides:</i> <a href="/w/index.php?title=TPI_ASM8&action=edit&redlink=1" class="new" title="TPI ASM8 (page does not exist)">TPI ASM8</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-6_receptor" title="Interleukin-6 receptor">IL-6</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Atexakin_alfa&action=edit&redlink=1" class="new" title="Atexakin alfa (page does not exist)">Atexakin alfa</a></li> <li><a href="/wiki/Interleukin_6" title="Interleukin 6">Interleukin 6</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/w/index.php?title=ARGX-109&action=edit&redlink=1" class="new" title="ARGX-109 (page does not exist)">ARGX-109</a></li> <li><a href="/wiki/Clazakizumab" title="Clazakizumab">Clazakizumab</a></li> <li><a href="/wiki/Elsilimomab" title="Elsilimomab">Elsilimomab</a></li> <li><a href="/w/index.php?title=MAb_1339&action=edit&redlink=1" class="new" title="MAb 1339 (page does not exist)">mAb 1339</a></li> <li><a href="/wiki/Olokizumab" title="Olokizumab">Olokizumab</a></li> <li><a href="/wiki/Sarilumab" title="Sarilumab">Sarilumab</a></li> <li><a href="/wiki/Siltuximab" title="Siltuximab">Siltuximab</a></li> <li><a href="/wiki/Sirukumab" title="Sirukumab">Sirukumab</a></li> <li><a href="/wiki/Tocilizumab" title="Tocilizumab">Tocilizumab</a></li> <li><a href="/wiki/Levilimab" title="Levilimab">Levilimab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-7_receptor" title="Interleukin-7 receptor">IL-7</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_7" title="Interleukin 7">Interleukin 7</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-8_receptor" title="Interleukin-8 receptor">IL-8</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ) <a href="/wiki/Template:Chemokine_receptor_modulators" title="Template:Chemokine receptor modulators">here</a> instead.</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin_9_receptor" class="mw-redirect" title="Interleukin 9 receptor">IL-9</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_9" title="Interleukin 9">Interleukin 9</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/w/index.php?title=Enokizumab&action=edit&redlink=1" class="new" title="Enokizumab (page does not exist)">Enokizumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-10_receptor" title="Interleukin-10 receptor">IL-10</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Ilodecakin&action=edit&redlink=1" class="new" title="Ilodecakin (page does not exist)">Ilodecakin</a></li> <li><a href="/wiki/Interleukin_10" title="Interleukin 10">Interleukin 10 (CSIF)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-11_receptor" title="Interleukin-11 receptor">IL-11</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_11" title="Interleukin 11">Interleukin 11 (AGIF)</a></li> <li><a href="/wiki/Oprelvekin" title="Oprelvekin">Oprelvekin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-12_receptor" title="Interleukin-12 receptor">IL-12</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Edodekin_alfa&action=edit&redlink=1" class="new" title="Edodekin alfa (page does not exist)">Edodekin alfa</a></li> <li><a href="/wiki/Interleukin_12" title="Interleukin 12">Interleukin 12</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Briakinumab" title="Briakinumab">Briakinumab</a></li> <li><a href="/wiki/Ustekinumab" title="Ustekinumab">Ustekinumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-13_receptor" title="Interleukin-13 receptor">IL-13</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Binetrakin&action=edit&redlink=1" class="new" title="Binetrakin (page does not exist)">Binetrakin</a></li> <li><a href="/w/index.php?title=Cintredekin_besudotox&action=edit&redlink=1" class="new" title="Cintredekin besudotox (page does not exist)">Cintredekin besudotox</a></li> <li><a href="/wiki/Interleukin_4" title="Interleukin 4">Interleukin 4</a></li> <li><a href="/wiki/Interleukin_13" title="Interleukin 13">Interleukin 13</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Anrukinzumab" title="Anrukinzumab">Anrukinzumab</a></li> <li><a href="/wiki/Lebrikizumab" title="Lebrikizumab">Lebrikizumab</a></li> <li><a href="/wiki/Tralokinumab" title="Tralokinumab">Tralokinumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-15_receptor" title="Interleukin-15 receptor">IL-15</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/ALT-803" class="mw-redirect" title="ALT-803">ALT-803</a></li> <li><a href="/wiki/Interleukin_15" title="Interleukin 15">Interleukin 15</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-17_receptor" title="Interleukin-17 receptor">IL-17</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_17" title="Interleukin 17">Interleukin 17</a> (<a href="/wiki/IL17A" class="mw-redirect" title="IL17A">A</a>, <a href="/w/index.php?title=IL17B&action=edit&redlink=1" class="new" title="IL17B (page does not exist)">B</a>, <a href="/w/index.php?title=IL17C&action=edit&redlink=1" class="new" title="IL17C (page does not exist)">C</a>, <a href="/w/index.php?title=IL17D&action=edit&redlink=1" class="new" title="IL17D (page does not exist)">D</a>, <a href="/wiki/IL17E" class="mw-redirect" title="IL17E">E (interleukin 25)</a>, <a href="/wiki/IL17F" class="mw-redirect" title="IL17F">F</a>)</li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Brodalumab" title="Brodalumab">Brodalumab</a></li> <li><a class="mw-selflink selflink">Ixekizumab</a></li> <li><a href="/wiki/Perakizumab" title="Perakizumab">Perakizumab</a></li> <li><a href="/w/index.php?title=Remtolumab&action=edit&redlink=1" class="new" title="Remtolumab (page does not exist)">Remtolumab</a></li> <li><a href="/wiki/Secukinumab" title="Secukinumab">Secukinumab</a></li> <li><a href="/w/index.php?title=Vunakizumab&action=edit&redlink=1" class="new" title="Vunakizumab (page does not exist)">Vunakizumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-18_receptor" title="Interleukin-18 receptor">IL-18</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Iboctadekin&action=edit&redlink=1" class="new" title="Iboctadekin (page does not exist)">Iboctadekin</a></li> <li><a href="/wiki/Interleukin_18" title="Interleukin 18">Interleukin 18</a></li> <li><a href="/wiki/Interleukin_37" title="Interleukin 37">Interleukin 37</a></li> <li><a href="/w/index.php?title=Tadekinig&action=edit&redlink=1" class="new" title="Tadekinig (page does not exist)">Tadekinig</a></li></ul> <ul><li><i>Binding proteins:</i> <a href="/wiki/IL18BP" title="IL18BP">IL18BP</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-20_receptor" title="Interleukin-20 receptor">IL-20</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_19" title="Interleukin 19">Interleukin 19</a></li> <li><a href="/wiki/Interleukin_20" title="Interleukin 20">Interleukin 20</a></li> <li><a href="/wiki/Interleukin_24" title="Interleukin 24">Interleukin 24</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Fletikumab" title="Fletikumab">Fletikumab</a> (against IL-20)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-21_receptor" title="Interleukin-21 receptor">IL-21</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Denenicokin&action=edit&redlink=1" class="new" title="Denenicokin (page does not exist)">Denenicokin</a></li> <li><a href="/wiki/Interleukin_21" title="Interleukin 21">Interleukin 21</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/w/index.php?title=NNC0114-0005&action=edit&redlink=1" class="new" title="NNC0114-0005 (page does not exist)">NNC0114-0005</a></li> <li><a href="/w/index.php?title=NNC0114-0006&action=edit&redlink=1" class="new" title="NNC0114-0006 (page does not exist)">NNC0114-0006</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-22_receptor" title="Interleukin-22 receptor">IL-22</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_22" title="Interleukin 22">Interleukin 22</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Fezakinumab" title="Fezakinumab">Fezakinumab</a> (against IL-22)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-23_receptor" title="Interleukin-23 receptor">IL-23</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_23" title="Interleukin 23">Interleukin 23 (SGRF)</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Brazikumab" title="Brazikumab">Brazikumab</a></li> <li><a href="/wiki/Briakinumab" title="Briakinumab">Briakinumab</a></li> <li><a href="/wiki/Guselkumab" title="Guselkumab">Guselkumab</a></li> <li><a href="/wiki/Risankizumab" title="Risankizumab">Risankizumab</a></li> <li><a href="/wiki/Tildrakizumab" title="Tildrakizumab">Tildrakizumab</a></li> <li><a href="/wiki/Ustekinumab" title="Ustekinumab">Ustekinumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-27_receptor" title="Interleukin-27 receptor">IL-27</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_27" title="Interleukin 27">Interleukin 27 (interleukin 30)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-28_receptor" title="Interleukin-28 receptor">IL-28</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Interferon_%CE%BB4&action=edit&redlink=1" class="new" title="Interferon λ4 (page does not exist)">Interferon λ4 (IFN-λ4)</a></li> <li><a href="/wiki/Interleukin_28" title="Interleukin 28">Interleukin 28</a> (<a href="/w/index.php?title=Interleukin_28A&action=edit&redlink=1" class="new" title="Interleukin 28A (page does not exist)">A (IFN-λ2)</a>, <a href="/wiki/Interleukin_28B" class="mw-redirect" title="Interleukin 28B">B (IFN-λ3)</a>)</li> <li><a href="/wiki/Interleukin_29" title="Interleukin 29">Interleukin-29 (IFN-λ1)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-31_receptor" title="Interleukin-31 receptor">IL-31</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_31" title="Interleukin 31">Interleukin 31</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin_1_receptor-like_1" class="mw-redirect" title="Interleukin 1 receptor-like 1">IL1RL1</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_33" title="Interleukin 33">Interleukin 33</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin_1_receptor-like_2" class="mw-redirect" title="Interleukin 1 receptor-like 2">IL1RL2</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_36" title="Interleukin 36">Interleukin 36</a> (<a href="/wiki/IL36A" title="IL36A">α</a>, <a href="/wiki/IL36B" title="IL36B">β</a>, <a href="/wiki/IL36G" title="IL36G">γ</a>)</li> <li><a href="/wiki/Interleukin_38" class="mw-redirect" title="Interleukin 38">Interleukin 38</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/wiki/Interleukin_36_receptor_antagonist" title="Interleukin 36 receptor antagonist">IL-36RA</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Janus_kinase" title="Janus kinase">JAK</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>See <a href="/wiki/Template:Cytokine_receptor_modulators" title="Template:Cytokine receptor modulators">here</a> instead.</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_14" class="mw-redirect" title="Interleukin 14">Interleukin 14 (taxilin alpha, HMW-BCGF)</a></li> <li><a href="/wiki/Interleukin_16" title="Interleukin 16">Interleukin 16</a> (signals through <a href="/wiki/CD4" title="CD4">CD4</a>)</li> <li><a href="/wiki/Interleukin_24" title="Interleukin 24">Interleukin 24</a> (signals through <a href="/wiki/IL22RA1" title="IL22RA1">IL-22Rα1</a>/<a href="/wiki/Interleukin_20_receptor,_beta_subunit" title="Interleukin 20 receptor, beta subunit">IL-20Rβ</a> heterodimer)</li> <li><a href="/wiki/Interleukin_26" title="Interleukin 26">Interleukin 26</a> (signals through <a href="/wiki/Interleukin_20_receptor,_alpha_subunit" title="Interleukin 20 receptor, alpha subunit">IL-20Rα</a>/<a href="/wiki/Interleukin_10_receptor,_beta_subunit" title="Interleukin 10 receptor, beta subunit">IL-10Rβ</a> heterodimer)</li> <li><a href="/wiki/Interleukin_32" title="Interleukin 32">Interleukin 32</a></li> <li><a href="/wiki/Interleukin_34" title="Interleukin 34">Interleukin 34</a> (signals through <a href="/wiki/Colony_stimulating_factor_1_receptor" title="Colony stimulating factor 1 receptor">M-CSFR/CSF1R</a>)</li> <li><a href="/wiki/Interleukin_35" title="Interleukin 35">Interleukin 35</a></li></ul> <ul><li><i>Unsorted:</i> <a href="/wiki/Efavaleukin_alfa" title="Efavaleukin alfa">Efavaleukin alfa</a></li> <li><a href="/w/index.php?title=Efineptakin_alfa&action=edit&redlink=1" class="new" title="Efineptakin alfa (page does not exist)">Efineptakin alfa</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table></div> <style data-mw-deduplicate="TemplateStyles:r1130092004">.mw-parser-output .portal-bar{font-size:88%;font-weight:bold;display:flex;justify-content:center;align-items:baseline}.mw-parser-output .portal-bar-bordered{padding:0 2em;background-color:#fdfdfd;border:1px solid #a2a9b1;clear:both;margin:1em auto 0}.mw-parser-output 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