Recombinant Human IL-22 Protein, CF (782-IL/CF): Novus Biologicals

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Protein, CF</h1> </div> <div class="clear"></div> <div> <div class="region region-content"> <div id="block-et-messages-et-messages-block" class="block block-et-messages"> <div class="content"> <span></span> </div> </div> <div id="block-system-main" class="block block-system"> <div class="content"> <div class="grid_16"><div class="ds_info float_left"><a href="#PublicationSection"><div class="sprite_pubBook_large"></div></a> <a href="#PublicationSection" class="bottom2"><span class="ctr">(65 Publications)</span></a></div><div class="ds_info float_left"> <a href="/common-name/il-22"><div class="sprite_allRelated"></div></a> <a href="/common-name/il-22" class="bottom4"><span class="ctr">See All Related</span></a> </div><div class="ds_info float_left"><a href="/reviews/782-IL/CF"><div class="dsSprite_submitreview"></div></a> <a href="/reviews/782-IL/CF" class="bottom4"><span class="ctr">Submit a Review</span></a></div></div></div><div class="modalWrapper" style="display:none;"> <h2>Species Glossary</h2> <hr class="customhr"/> <img src="//images.novusbio.com/design/bunny.gif" alt="Species Glossary Rabbit" style="float: right;"> <table class="modalTable"> <tr> <td>At</td> <td>=</td> <td>A. thaliana</td> <td>SyHa</td> <td>=</td> <td>Golden Syrian Hamster</td> </tr> <tr> <td>All</td> <td>=</td> <td>All Species</td> <td>Ha</td> <td>=</td> <td>Hamster</td> </tr> <tr> <td>An</td> <td>=</td> <td>Animal</td> <td>Hu</td> <td>=</td> <td>Human</td> </tr> <tr> <td>ArHa</td> <td>=</td> <td>Armenian Hamster</td> <td>I</td> <td>=</td> <td>Insect</td> </tr> <tr> <td>Av</td> <td>=</td> <td>Avian</td> <td>Ll</td> <td>=</td> <td>Llama</td> </tr> <tr> <td>Bb</td> <td>=</td> <td>Baboon</td> <td>Ma</td> <td>=</td> <td>Mammal</td> </tr> <tr> <td>Ba</td> <td>=</td> <td>Bacteria</td> <td>Mk</td> <td>=</td> <td>Monkey</td> </tr> <tr> <td>Bv</td> <td>=</td> <td>Bovine</td> <td>Mu</td> <td>=</td> <td>Mouse</td> </tr> <tr> <td>Ca</td> <td>=</td> <td>Canine</td> <td>Multi</td> <td>=</td> <td>Multi-species</td> </tr> <tr> <td>Ce</td> <td>=</td> <td>C. Elegans</td> <td>NA</td> <td>=</td> <td>Non-species specific</td> </tr> <tr> <td>Ch</td> <td>=</td> <td>Chicken</td> <td>Or</td> <td>=</td> <td>Orangutan</td> </tr> <tr> <td>ChHa</td> <td>=</td> <td>Chinese Hamster</td> <td>Pl</td> <td>=</td> <td>Plant</td> </tr> <tr> <td>Cm</td> <td>=</td> <td>Cynomolgus Monkey</td> <td>Pm</td> <td>=</td> <td>Primate</td> </tr> <tr> <td>Do</td> <td>=</td> <td>Donkey</td> <td>Po</td> <td>=</td> <td>Porcine</td> </tr> <tr> <td>Dr</td> <td>=</td> <td>Drosophilia</td> <td>Rb</td> <td>=</td> <td>Rabbit</td> </tr> <tr> <td>Ec</td> <td>=</td> <td>E. Coli</td> <td>Rt</td> <td>=</td> <td>Rat</td> </tr> <tr> <td>Eq</td> <td>=</td> <td>Equine</td> <td>RM</td> <td>=</td> <td>Rhesus Macaque</td> </tr> <tr> <td>Fe</td> <td>=</td> <td>Feline</td> <td>Sh</td> <td>=</td> <td>Sheep</td> </tr> <tr> <td>Ft</td> <td>=</td> <td>Ferret</td> <td>Vb</td> <td>=</td> <td>Vertebrate</td> </tr> <tr> <td>Fi</td> <td>=</td> <td>Fish</td> <td>Vi</td> <td>=</td> <td>Virus</td> </tr> <tr> <td>Fu</td> <td>=</td> <td>Fungi</td> <td>Xp</td> <td>=</td> <td>Xenopus</td> </tr> <tr> <td>Ge</td> <td>=</td> <td>Gerbil</td> <td>Ye</td> <td>=</td> <td>Yeast</td> </tr> <tr> <td>GP</td> <td>=</td> <td>Guinea Pig</td> <td>Ze</td> <td>=</td> <td>Zebrafish</td> </tr> <tr> <td>Gt</td> <td>=</td> <td>Goat</td> </tr> </table> <div style="text-align: center;margin-left:25px;margin-right:25px;"> <p>Note: Mouseover a species abbreviation on the product page to display the fullname.</p> </div> </div> </div><div class="clear"></div><div class="grid_10 pos_relative"><div class="ds_blue_border equaltop"><div class="imagesleft equaltop"><h2 class="blueHead">Images</h2> <div class="midBlue"> </div><div class="images"><div id="ss_prev_top" class="cycle-pager"><div class="pager_left_on"></div></div><div class="cycle-slideshow slideshows" data-cycle-fx="fade" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-top" data-cycle-prev="#ss_prev_top" data-cycle-next="#ss_next_top" data-cycle-caption="#image-caption" data-cycle-caption-template="Image {{slideNum}} of {{slideCount}}" data-cycle-slides=".big_thumb_container" data-cycle-carousel-visible="2" id="images_cycle" > <div class="sub_image_wrapper"><div id="cycle-circle-pager-top" class="cycle-circle-pager"></div><div id="image-caption"></div> <a class="enlargeTop">(<div class="dsSprite_magGlass"></div> Enlarge)</a></div> <div class="big_thumb_container"> <div class="image_wrapper"> <a href="//images.novusbio.com/fullsize2/IL-22_782-IL_CF_743.jpg" class="top_images" rel="gallery" title="Recombinant Human IL-22 (Catalog # 782‑IL/CF) induces IL-10 secretion in the COLO 205 human colorectal adenocarcinoma cell line. The ED50 for this effect is 60‑300 pg/mL." > <img src="//images.novusbio.com/images2/IL-22_782-IL_CF_743.jpg" class="big_thumb" alt="Recombinant Human IL-22 (Catalog # 782‑IL/CF) induces IL-10 secretion in the COLO 205 human colorectal adenocarcinoma cell line. The ED50 for this effect is 60‑300 pg/mL." title="Recombinant Human IL-22 (Catalog # 782‑IL/CF) induces IL-10 secretion in the COLO 205 human colorectal adenocarcinoma cell line. The ED50 for this effect is 60‑300 pg/mL." /> </a> </div> <div class="alt-caption padding_left5" >Recombinant Human IL-22 (Catalog # 782‑IL/CF) induces IL-10 secretion in the COLO 205 human colorectal adenocarcinoma cell line. The ED50 for this effect is 60‑300 pg/mL.</div> </div> <div class="big_thumb_container"> <div class="image_wrapper"> <a href="//images.novusbio.com/fullsize2/IL-22_782-IL_CF_734.jpg" class="top_images" rel="gallery" title="1 µg/lane of Recombinant Human IL-22 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 14 kDa." > <img src="//images.novusbio.com/images2/IL-22_782-IL_CF_734.jpg" loading="lazy" style="display:none;" class="big_thumb" alt="1 µg/lane of Recombinant Human IL-22 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 14 kDa." title="1 µg/lane of Recombinant Human IL-22 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 14 kDa." /> </a> </div> <div class="alt-caption padding_left5" >1 µg/lane of Recombinant Human IL-22 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 14 kDa.</div> </div></div><div id="ss_next_top" class="cycle-pager"><div class="pager_right_on"></div></div></div></div><div class="productsright pos_relative equaltop"><h2 class="blueHead">Product Details</h2> <div class="midBlue">Summary</div><table class="ds_list"><tr class="lined"> <td><strong>Reactivity</strong></td> <td><span title='Human'>Hu</span><span class="myModal">Species Glossary</span></td> </tr><tr class="lined"> <td><strong>Applications</strong></td> <td><span title='Bioactivity'>Bioactivity</span></td> </tr><tr class="lined"> <td><strong>Format</strong></td> <td><div>Carrier-Free</div></td> </tr></table></div> </div></div><div class="grid_6"><div></div> <div class="ds_blue_border equaltop"> <h2 class="blueHead_nopadding">Order Details</h2><ul class="ds_details"><li class="add-to-cart" data-type="full" data-prodname="Recombinant Human IL-22 Protein, CF" data-catnum="782-IL/CF" data-catnums="782-IL-010/CF" data-disabled=''><noscript><form autocomplete="off" action="/products/recombinant-human-il-22-protein-cf_782-il-cf" method="post" id="et-add-multiple-to-cart-form" accept-charset="UTF-8"><div><table class="sticky-enabled"> <thead><tr><th>Size</th><th>Price</th> </tr></thead> <tbody> <tr class="odd"><td><div class="atc_size" title="catalog # 782-IL-010/CF">10 ug</div><div data-msg='' class="atc_catnum">782-IL-010/CF</div></td><td><div style="font-size:11px;"><a class="jump_distributor" href="#jump_distributor">Contact Your<br />Distributor</a></div></td> </tr> <tr class="even"><td colspan="3" class="stock_row">4-6 Business Days</td> </tr> </tbody> </table> <input type="hidden" name="form_build_id" value="form-1Z2KGOnlW3jJucSVaFntgEXHLSklOhXdoExyDeaBGuw" /> <input type="hidden" name="form_id" value="et_add_multiple_to_cart_form" /> </div></form></noscript></li></ul><div id="shipping" class="hidden"></td></tr></div><div class="conj_form_buttons"><div class="list_expand options_closed" data-name="Formulations" data-wrapper-type=".formulations_wrapper"><div class="options_text">View Available Formulations</div> <div class="expander option_closed"></div></div><div class="formulations_wrapper" data-title="Recombinant Human IL-22 Protein, CF" data-catnum="782-IL/CF"><table class="scf_table"> <thead> <tr> <th>Catalog# & Formulation</th> <th>Size</th> <th class="col_price">Price</th> <th class="col_cart"></th> </tr> </thead> <tbody><tr class="popup_sku" data-sku="782-IL-010"> <td> <a href="/products/recombinant-human-il-22-protein_782-il" class="conj_link">Standard Formulation</a><br /> <a href="/products/recombinant-human-il-22-protein_782-il" class="cat_link">782-IL-010</a> </td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> <td class="col_cart"><a href="/commerce/add-to-cart/446467"><div class="purchase_cart"></div></a></td> </tr> <tr> <td colspan="4" class="row_stock"><div class="popup_stock"></div></td> </tr> <tr class="scf_footer"> <td colspan="4"><div class="expander option_opened"></div></td> </tr> </tbody> </table> <div class="popup_skus" data-skus='["782-IL-010"]' data-rendered="false"></div></div></div><div id="shipping_statement"><span id="shipping_rate"></span></div><div class="shipping_obt_transfer"><span>Novus Biologicals is part of Bio-Techne</span><br><br><a href="https://www.bio-techne.com/p/proteins-enzymes/recombinant-human-il-22-protein-cf_782-il-cf" rel="follow" class="btn btn-primary">Shop this product on bio-techne.com</a></div><br><div class="learn_more"> <a href="/guarantee"> <div class="sprite_noImage" title="Novus Biologicals, part of Bio-Techne, offers 100% Guarantee"></div> <div class="learn_more_text">Novus Biologicals, part of Bio-Techne, offers 100% Guarantee</div></a> </div><span id="conj_form" class="hidden"><tr><td colspan="4"></td></tr></span> </div> </div><div class="clear"></div><div class="grid_10"><div><div id="ds_tabs" style="display:none;"> <div class="ds_tab_active" id="dsTabs_datasheet" data-anchor_desc="datasheet">Datasheet</div> <div class="ds_tab" id="dsTabs_reviews-publications" data-anchor_desc="reviews-publications">Reviews & Publications</div> <div class="ds_tab" id="dsTabs_protocols-faqs" data-anchor_desc="protocols-faqs">Protocols & FAQs</div> <div class="ds_tab" id="dsTabs_supportresearch" data-anchor_desc="supportresearch">Support & Research</div> </div><div class="ds_tab_content equalbottom" id="content_datasheet" > <a id="datasheet"></a><h2 class=greyHead2>Recombinant Human IL-22 Protein, CF Summary</h2> <div class="ds_info"> <a id="tab1details"></a> <table class="ds_list wide" style="table-layout:fixed;"> <tr class="lined"> <td><strong>Additional Information</strong></td> <td><div>E. coli</div></td> </tr><tr class="lined"> <td><strong>Details of Functionality</strong></td> <td><div>Measured by its ability to induce IL-10 secretion in COLO 205 human colorectal adenocarcinoma cells. Nagalakshmi, M.L. <EM>et al</EM>. (2004) International Immunopharmacology <STRONG>4</STRONG>:679. The ED<SUB>50</SUB> for this effect is 60-300 pg/mL.</div></td> </tr><tr class="lined"> <td><strong>Source</strong></td> <td><div><EM>E. coli</EM>-derived human IL-22 protein<br />Ala34-Ile179, with an N-terminal Met</div></td> </tr><tr class="lined"> <td><strong>Accession #</strong></td> <td><div><a href="http://www.ncbi.nlm.nih.gov/protein/Q9GZX6" target="_blank" >Q9GZX6</a></div></td> </tr><tr class="lined"> <td><strong>N-terminal Sequence</strong></td> <td><div>Met</div></td> </tr><tr class="lined"> <td><strong> Protein/Peptide Type</strong></td> <td><div>Recombinant Proteins</div></td> </tr><tr class="lined"> <td><strong>Gene</strong></td> <td><div>IL22</div></td> </tr><tr class="lined"> <td><strong>Purity</strong></td> <td><div>>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.</div></td> </tr><tr class="lined"> <td><strong>Endotoxin Note</strong></td> <td><div><0.10 EU per 1 μg of the protein by the LAL method.</div></td> </tr> </table> </div> <h2 class="greyHead2">Applications/Dilutions</h2> <div class="ds_info"> <a id="tab1appsdiluts"></a> <table class="ds_list wide"> <tr class="lined"> <td><strong>Dilutions</strong></td> <td> <ul class="ds_noDotList"><li>Bioactivity </li> </ul> </td> </tr><tr class="lined"> <td><strong>Theoretical MW</strong></td> <td><div>16.5 kDa.<br> Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.</div></td> </tr><tr class="lined"> <td><strong>Publications</strong></td> <td> <table> <tr> <td>Read <a href="#PublicationSection"> Publications</a> using<br/> 782-IL/CF in the following applications:<br /><br /> <ul class="information-list"><li class="noIndent"><div class="information-subject"> <a href="#PublicationSection" class="filter_link" data-destination="publication" data-type="application" data-filter="Bioassay">Bioassay</a> </div><div class="information-data">53 publications</div></li><li class="noIndent"><div class="information-subject"> <a href="#PublicationSection" class="filter_link" data-destination="publication" data-type="application" data-filter="Cell Culture">Cell Culture</a> </div><div class="information-data">4 publications</div></li><li class="noIndent"><div class="information-subject"> <a href="#PublicationSection" class="filter_link" data-destination="publication" data-type="application" data-filter="ELISA (Capture)">ELISA (Capture)</a> </div><div class="information-data">1 publication</div></li><li class="noIndent"><div class="information-subject"> <a href="#PublicationSection" class="filter_link" data-destination="publication" data-type="application" data-filter="ELISA (Standard)">ELISA (Standard)</a> </div><div class="information-data">2 publications</div></li><li class="noIndent"><div class="information-subject"> <a href="#PublicationSection" class="filter_link" data-destination="publication" data-type="application" data-filter="Stimulation">Stimulation</a> </div><div class="information-data">3 publications</div></li><li class="noIndent"><div class="information-subject"> <a href="#PublicationSection" class="filter_link" data-destination="publication" data-type="application" data-filter="Surface Plasmon Resonance">Surface Plasmon Resonance</a> </div><div class="information-data">1 publication</div></li><li class="noIndent"><div class="information-subject"> <a href="#PublicationSection" class="filter_link" data-destination="publication" data-type="application" data-filter="Western Blot">Western Blot</a> </div><div class="information-data">1 publication</div></li></ul></td> </tr> </table> </td> </tr> </table> </div> <h2 class="greyHead2">Packaging, Storage & Formulations</h2><div class="ds_info"><table class="ds_list"><tr class="lined"> <td><strong>Storage</strong></td> <td><div><b>Use a manual defrost freezer and avoid repeated freeze-thaw cycles.</b><UL><LI>12 months from date of receipt, -20 to -70 °C as supplied.</LI><LI>1 month, 2 to 8 °C under sterile conditions after reconstitution.</LI><LI>3 months, -20 to -70 °C under sterile conditions after reconstitution.</LI></UL></div></td> </tr><tr class="lined"> <td><strong>Buffer</strong></td> <td><div>Lyophilized from a 0.2 μm filtered solution in PBS.</div></td> </tr><tr class="lined"> <td><strong>Purity</strong></td> <td><div>>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.</div></td> </tr><tr class="lined"> <td><strong>Reconstitution Instructions</strong></td> <td><div>Reconstitute at 100 μg/mL in sterile PBS.</div></td> </tr></table></div> <h2 class="greyHead2">Notes</h2><div class="ds_info"> <a id="tab1notes"></a> <div>This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.</div> </div><h2 class="greyHead2">Alternate Names for Recombinant Human IL-22 Protein, CF</h2> <div class="ds_info"> <a id="tab1altnames"></a> <div class="information-list"> <ul><li>Cytokine Zcyto18</li><li>IL-10-related T-cell-derived inducible factor</li><li>IL22</li><li>IL-22</li><li>IL-D110</li><li>IL-TIF</li><li>ILTIFIL-10-related T-cell-derived-inducible factor</li><li>IL-TIFMGC79382</li><li>interleukin 22</li><li>interleukin-22</li><li>MGC79384</li><li>TIFa</li><li>TIFIL-23</li><li>zcyto18</li></ul></div> </div> <h2 class="greyHead2">Background</h2> <div class="ds_info"> <a id="tab1background"></a> <div><p>Interleukin-22 (IL-22), also known as IL-10-related T cell-derived inducible factor (IL-TIF) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. Human IL-22 cDNA encodes a 179 amino acid (aa) residue protein with a putative 33 aa signal peptide that is cleaved to generate a 147 aa mature protein that shares approximately 79% and 22% aa sequence identity with mouse IL-22 and human IL-10, respectively. The human IL-22 gene is localized to chromosome 12q15. Although it exists as a single copy gene in human and in many mouse strains, the mouse IL-22 gene is duplicated in some mouse strains including C57B1/6, FVB and 129. The two mouse genes designated IL-TIF alpha and IL-TIF beta , share greater than 98% sequence homology in their coding region. IL-22 has been shown to activate STAT‑1 and STAT-3 in several hepatoma cell lines and upregulate the production of acute phase proteins. IL-22 is produced by normal T cells upon anti-CD3 stimulation in humans. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection, suggesting that IL-22 may be involved in inflammatory responses. The functional IL-22 receptor complex consists of two receptor subunits, IL-22R (previously an orphan receptor named CRF2-9) and IL-10R beta (previously known as CRF2-4), belonging to the class II cytokine receptor family.</p><div class="backref"><ol> <li>Dumoutier, L. <em>et al</em>. (2000) J. Immunol. <strong>164</strong>:1814.</li> <li>Xie, M-H. <em>et al</em>. (2000) J. Biol. Chem. <strong>275</strong>:31335.</li> <li>Dumoutier, L. <em>et al</em>. (2000) PNAS <strong>97</strong>:10144.</li> <li>Kotenko, S.V. <em>et al</em>. (2001) J. Biol. 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(n = 5, **P &lt; 0.01). (e~h) Relative mRNA expression of IL-6 (e), TNF-alpha (f), IL-1 beta (g) and VEGF (h) in the chondrocytes isolated from the 8-week ND or HFD-feeding mice. (n = 5, **P &lt; 0.01). Image collected and cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/26271607), licensed under a CC-BY license. Not internally tested by R&amp;D Systems." class="cust_viewed_2" > <img loading="lazy" src="https://images.novusbio.com/images/m6000b_mouse-il-6-quantikine-elisa-kit-44202415433118.jpg" alt="N/A IL-6 [HRP]" class="big_thumb" /> </a> </div></div><div id="ss_next_cav2" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-2" class="cycle-circle-pager"></div></div> <div class="ds_info"> <div class="tiny"> <a href="/products/mouse-il-6-quantikine-elisa-kit-2-plate_m6000b#PublicationSection"> <div class="sprite_pubBook"></div> (676 Publications</a>) </div><div class="tiny"><strong>Species:</strong> Mu</div><div class="tiny"><strong>Applications:</strong> ELISA</div> </div> </div> </div> <div class="ds_cav_block"> <div class="ds_cav_upper" data-catnums="DY417"> <div class="name"> <div class="flourish_left"></div> <div class="flourish_right"></div> <a href="/products/mouse-il-10-duoset-elisa-15-plate_dy417" style="overflow: hidden; width: 280px;" title="IL-10 [Biotin]">IL-10 [Biotin]</a>    </div><div class="sub-header">DY417</div> <div class="images_customers"><div class="one_image_l"></div><div class="cycle-slideshow" data-cycle-fx="fade" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-3" data-cycle-prev="#ss_prev_cav3" data-cycle-next="#ss_next_cav3" data-cycle-slides="div.big_thumb_cust_container" data-index=3 ><div class="big_thumb_cust_container"> <a href="/products/mouse-il-10-duoset-elisa-15-plate_dy417" title="" class="cust_viewed_3" > <img loading="lazy" src="https://images.novusbio.com/images2/DATA_IL10_DY417_ELISA_2014.jpg" alt="N/A IL-10 [Biotin]" class="big_thumb" /> </a> </div></div><div class="one_image"></div><div class="one_image_11"></div></div> <div class="ds_info"> <div class="tiny"> <a href="/products/mouse-il-10-duoset-elisa-15-plate_dy417#PublicationSection"> <div class="sprite_pubBook"></div> (304 Publications</a>) </div><div class="tiny"><strong>Species:</strong> Mu</div><div class="tiny"><strong>Applications:</strong> ELISA</div> </div> </div> </div></div><div class="ds_cav_group"> <div class="ds_cav_block"> <div class="ds_cav_upper" data-catnums="NBP1-19371"> <div class="name"> <div class="flourish_left"></div> <div class="flourish_right"></div> <a href="/products/cd4-antibody_nbp1-19371" style="overflow: hidden; width: 280px;" title="CD4 Antibody - BSA Free">CD4 Antibody - BSA<br> Free</a>    </div><div class="sub-header">NBP1-19371</div> <div class="images_customers"><div id="ss_prev_cav4" class="cycle-pager"> <div class="pager_left_on"></div></div><div class="cycle-slideshow" data-cycle-fx="fade" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-4" data-cycle-prev="#ss_prev_cav4" data-cycle-next="#ss_next_cav4" data-cycle-slides="div.big_thumb_cust_container" data-index=4 ><div class="big_thumb_cust_container"> <a href="/products/cd4-antibody_nbp1-19371" title="Immunohistochemistry-Frozen: CD4 Antibody [NBP1-19371] - Staining in mouse liver tissue." class="cust_viewed_4" > <img loading="lazy" src="https://images.novusbio.com/images/CD4-Antibody-Immunohistochemistry-Frozen-NBP1-19371-img0013.jpg" alt="Immunohistochemistry-Frozen CD4 Antibody - BSA Free" class="big_thumb" /> </a> </div><div class="big_thumb_cust_container"> <a href="/products/cd4-antibody_nbp1-19371" title="Immunohistochemistry-Paraffin: CD4 Antibody [NBP1-19371] - Alcohol-fixed paraffin-embedded rat spleen tissue. Dilution 1:150. Image from verified customer review." class="cust_viewed_4" > <img loading="lazy" src="https://images.novusbio.com/images/CD4-Antibody-Immunohistochemistry-Paraffin-NBP1-19371-img0014.jpg" alt="Immunohistochemistry-Paraffin CD4 Antibody - BSA Free" class="big_thumb" /> </a> </div><div class="big_thumb_cust_container"> <a href="/products/cd4-antibody_nbp1-19371" title="Flow Cytometry: CD4 Antibody [NBP1-19371] - An intracellular stain was performed on Jurkat cells with CD4 Antibody NBP1-19371R (blue) and a matched isotype control (orange). Cells were fixed with 4% PFA and then permeabilized with 0.1% saponin. Cells were incubated in an antibody dilution of 5 ug/mL for 30 minutes at room temperature. Both antibodies were conjugated to DyLight 550." class="cust_viewed_4" > <img loading="lazy" src="https://images.novusbio.com/images/CD4-Antibody-Flow-Cytometry-NBP1-19371-img0015.jpg" alt="Flow Cytometry CD4 Antibody - BSA Free" class="big_thumb" /> </a> </div></div><div id="ss_next_cav4" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-4" class="cycle-circle-pager"></div></div> <div class="ds_info"> <div class="tiny"> <a href="/products/cd4-antibody_nbp1-19371#ReviewsSection"> <div class="sprite_4Stars"></div> (9 Reviews</a>) </div> <div class="tiny"> <a href="/products/cd4-antibody_nbp1-19371#PublicationSection"> <div class="sprite_pubBook"></div> (52 Publications</a>) </div><div class="tiny"><strong>Species:</strong> Ca, Hu, Mu, Po, Rb, Rt</div><div class="tiny"><strong>Applications:</strong> Dual ISH-IHC, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, Simple Western, WB</div> </div> </div> </div> <div class="ds_cav_block"> <div class="ds_cav_upper" data-catnums="1290-IL"> <div class="name"> <div class="flourish_left"></div> <div class="flourish_right"></div> <a href="/products/recombinant-human-il-23-protein_1290-il" style="overflow: hidden; width: 280px;" title="IL-23A/IL-23 P19 [Unconjugated]">IL-23A/IL-23 P19<br> [Unconjugated]</a>    </div><div class="sub-header">1290-IL</div> <div class="images_customers"><div class="one_image_l"></div><div class="cycle-slideshow" data-cycle-fx="fade" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-5" data-cycle-prev="#ss_prev_cav5" data-cycle-next="#ss_next_cav5" data-cycle-slides="div.big_thumb_cust_container" data-index=5 ><div class="big_thumb_cust_container"> <a href="/products/recombinant-human-il-23-protein_1290-il" title="Recombinant Human IL-23 Protein (Catalog # 1290-IL) has a molecular weight (MW) of 57.9 kDa as analyzed by SEC-MALS, suggesting that this protein is a heterodimer. MW may differ from predicted MW due to post-translational modifications (PTMs) present (i.e. Glycosylation)." class="cust_viewed_5" > <img loading="lazy" src="https://images.novusbio.com/images/1290-il_recombinant-human-il-23-protein-sec-mals-1012202411154..jpg" alt="SEC-MALS IL-23A/IL-23 P19 [Unconjugated]" class="big_thumb" /> </a> </div></div><div class="one_image"></div><div class="one_image_11"></div></div> <div class="ds_info"> <div class="tiny"> <a href="/products/recombinant-human-il-23-protein_1290-il#PublicationSection"> <div class="sprite_pubBook"></div> (115 Publications</a>) </div><div class="tiny"><strong>Species:</strong> Hu</div><div class="tiny"><strong>Applications:</strong> BA</div> </div> </div> </div></div><div class="ds_cav_group"> <div class="ds_cav_block"> <div class="ds_cav_upper" data-catnums="202-IL"> <div class="name"> <div class="flourish_left"></div> <div class="flourish_right"></div> <a href="/products/recombinant-human-il-2-protein_202-il" style="overflow: hidden; width: 280px;" title="IL-2 [Unconjugated]">IL-2 [Unconjugated]</a>    </div><div class="sub-header">202-IL</div> <div class="images_customers"><div class="one_image_l"></div><div class="cycle-slideshow" data-cycle-fx="fade" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-6" data-cycle-prev="#ss_prev_cav6" data-cycle-next="#ss_next_cav6" data-cycle-slides="div.big_thumb_cust_container" data-index=6 ><div class="big_thumb_cust_container"> <a href="/products/recombinant-human-il-2-protein_202-il" title="As an alternative, please consider our next generation Recombinant Human IL-2 (BT-002). It has equivalent bioactivity to Recombinant Human IL-2 (Catalog # 202-IL). It combines R&amp;D Systems quality with scalability that allows for a solid supply chain. Both Recombinant Human IL-2 proteins are measured in a cell proliferation assay using CTLL 2 mouse cytotoxic T cells." class="cust_viewed_6" > <img loading="lazy" src="https://images.novusbio.com/images/202-il_recombinant-human-il-2-protein-bioactivity-174202314946.jpg" alt="Bioactivity IL-2 [Unconjugated]" class="big_thumb" /> </a> </div></div><div class="one_image"></div><div class="one_image_11"></div></div> <div class="ds_info"> <div class="tiny"> <a href="/products/recombinant-human-il-2-protein_202-il#ReviewsSection"> <div class="sprite_5Stars"></div> (4 Reviews</a>) </div> <div class="tiny"> <a href="/products/recombinant-human-il-2-protein_202-il#PublicationSection"> <div class="sprite_pubBook"></div> (378 Publications</a>) </div><div class="tiny"><strong>Species:</strong> Hu</div><div class="tiny"><strong>Applications:</strong> BA</div> </div> </div> </div> <div class="ds_cav_block"> <div class="ds_cav_upper" data-catnums="210-TA"> <div class="name"> <div class="flourish_left"></div> <div class="flourish_right"></div> <a href="/products/recombinant-human-tnf-alpha-protein_210-ta" style="overflow: hidden; width: 280px;" title="TNF-alpha [Unconjugated]">TNF-alpha<br> [Unconjugated]</a>    </div><div class="sub-header">210-TA</div> <div class="images_customers"><div id="ss_prev_cav7" class="cycle-pager"> <div class="pager_left_on"></div></div><div class="cycle-slideshow" data-cycle-fx="fade" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-7" data-cycle-prev="#ss_prev_cav7" data-cycle-next="#ss_next_cav7" data-cycle-slides="div.big_thumb_cust_container" data-index=7 ><div class="big_thumb_cust_container"> <a href="/products/recombinant-human-tnf-alpha-protein_210-ta" title="1 µg/lane of Recombinant Human TNF-alpha was resolved by SDS-PAGE with silver staining, under reducing (R) conditions, showing a band at 17 kDa." class="cust_viewed_7" > <img loading="lazy" src="https://images.novusbio.com/images2/TNF-alpha_210-TA_256.jpg" alt="SDS-PAGE TNF-alpha [Unconjugated]" class="big_thumb" /> </a> </div><div class="big_thumb_cust_container"> <a href="/products/recombinant-human-tnf-alpha-protein_210-ta" title="Recombinant Human TNF-alpha (Catalog # 210‑TA) induces cytotoxicity in the L-929 mouse fibroblast cell line in the presence of the metabolic inhibitor actinomycin D. The ED50 for this effect is 25‑100 pg/mL." class="cust_viewed_7" > <img loading="lazy" src="https://images.novusbio.com/images2/TNFalpha_210TA_1658.jpg" alt="Bioactivity TNF-alpha [Unconjugated]" class="big_thumb" /> </a> </div><div class="big_thumb_cust_container"> <a href="/products/recombinant-human-tnf-alpha-protein_210-ta" title="Recombinant Human TNF-alpha (Catalog # 210-TA) has a molecular weight (MW) of 53.1 kDa as analyzed by SEC-MALS, suggesting that this protein is a homotrimer. MW may differ from predicted MW due to post-translational modifications (PTMs) present (i.e. Glycosylation)." class="cust_viewed_7" > <img loading="lazy" src="https://images.novusbio.com/images/210-ta_recombinant-human-tnf-alpha-protein-sec-mals-35202312244..jpg" alt="SEC-MALS TNF-alpha [Unconjugated]" class="big_thumb" /> </a> </div></div><div id="ss_next_cav7" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-7" class="cycle-circle-pager"></div></div> <div class="ds_info"> <div class="tiny"> <a href="/products/recombinant-human-tnf-alpha-protein_210-ta#ReviewsSection"> <div class="sprite_5Stars"></div> (3 Reviews</a>) </div> <div class="tiny"> <a href="/products/recombinant-human-tnf-alpha-protein_210-ta#PublicationSection"> <div class="sprite_pubBook"></div> (821 Publications</a>) </div><div class="tiny"><strong>Species:</strong> Hu</div><div class="tiny"><strong>Applications:</strong> BA</div> </div> </div> </div></div><div class="ds_cav_group"> <div class="ds_cav_block"> <div class="ds_cav_upper" data-catnums="MAB1799"> <div class="name"> <div class="flourish_left"></div> <div class="flourish_right"></div> <a href="/products/stat3-antibody-232209_mab1799" style="overflow: hidden; width: 280px;" title="STAT3 Antibody (232209) [Unconjugated]">STAT3 Antibody<br> (232209) [Unconjugate</a>    </div><div class="sub-header">MAB1799</div> <div class="images_customers"><div id="ss_prev_cav8" class="cycle-pager"> <div class="pager_left_on"></div></div><div class="cycle-slideshow" data-cycle-fx="fade" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-8" data-cycle-prev="#ss_prev_cav8" data-cycle-next="#ss_next_cav8" data-cycle-slides="div.big_thumb_cust_container" data-index=8 ><div class="big_thumb_cust_container"> <a href="/products/stat3-antibody-232209_mab1799" title="STAT3 was detected in immersion fixed HeLa human cervical epithelial carcinoma cell line treated with IFN-alpha 1, but is not detected in STAT3 knockout (KO) HeLa cell line using Mouse Anti-Human/ Mouse/Rat STAT3 Monoclonal Antibody (Catalog # MAB1799) at 1 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights&amp;#8482; 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # NL007) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm and nuclei. View our protocol for Fluorescent ICC Staining of Cells on Coverslips." class="cust_viewed_8" > <img loading="lazy" src="https://images.novusbio.com/images2/STAT3_MAB1799_Simple_Western_21000.jpg" alt="Knockout Validated STAT3 Antibody (232209) [Unconjugated]" class="big_thumb" /> </a> </div><div class="big_thumb_cust_container"> <a href="/products/stat3-antibody-232209_mab1799" title="Western Blot shows lysates of HepG2 human hepatocellular carcinoma cell line, NCI&amp;#x2011;H1703 human non-small cell lung carcinoma cell line, C6 rat glioma cell line and NIH&amp;#x2011;3T3 mouse embryonic fibroblast cell line. PVDF membrane was probed with 1&amp;nbsp;µg/ml of Mouse Anti-Human/Mouse/Rat STAT3 Monoclonal Antibody (Catalog # MAB1799) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog&amp;#160;# HAF018). A specific band was detected for STAT3 at approximately 86&amp;nbsp;kDa (as indicated). This experiment was conducted under reducing conditions and using Western Blot Buffer Group 1." class="cust_viewed_8" > <img loading="lazy" src="https://images.novusbio.com/images2/STAT3_MAB1799_Western_Blot_5993.jpg" alt="Western Blot STAT3 Antibody (232209) [Unconjugated]" class="big_thumb" /> </a> </div><div class="big_thumb_cust_container"> <a href="/products/stat3-antibody-232209_mab1799" title="Western blot shows lysates of HeLa human cervical epithelial carcinoma parental cell line, STAT1 knockout (KO) HeLa cell line, STAT2 KO HeLa cell line, STAT3 KO HeLa cell line, STAT5a KO HeLa cell line, STAT5b KO HeLa cell line, STAT6 KO HeLa cell line,. PVDF membrane was probed with 0.5 µg/mL of Mouse Anti-Human/Mouse/Rat STAT3 Monoclonal Antibody (Catalog # MAB1799) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF018). A specific band was detected for STAT3 at approximately 80 kDa (as indicated) in the parental HeLa cell line, but is not detectable in the STAT3 knockout HeLa cell line. GAPDH (Catalog # AF5718) is shown as a loading control. This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." class="cust_viewed_8" > <img loading="lazy" src="https://images.novusbio.com/images2/STAT3_MAB1799_Knockout_Validated_21531.jpg" alt="Knockout Validated STAT3 Antibody (232209) [Unconjugated]" class="big_thumb" /> </a> </div></div><div id="ss_next_cav8" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-8" class="cycle-circle-pager"></div></div> <div class="ds_info"> <div class="tiny"> <a href="/products/stat3-antibody-232209_mab1799#PublicationSection"> <div class="sprite_pubBook"></div> (23 Publications</a>) </div><div class="tiny"><strong>Species:</strong> Hu, Mu, Rt</div><div class="tiny"><strong>Applications:</strong> ICC, IP, ICFlow, KO, WB</div> </div> </div> </div> <div class="ds_cav_block"> <div class="ds_cav_upper" data-catnums="6507-IL/CF"> <div class="name"> <div class="flourish_left"></div> <div class="flourish_right"></div> <a href="/products/recombinant-human-il-4-cho-expressed-protein-cf_6507-il-cf" style="overflow: hidden; width: 280px;" title="IL-4 [Unconjugated]">IL-4 [Unconjugated]</a>    </div><div class="sub-header">6507-IL/CF</div> <div class="images_customers"><div class="one_image_l"></div><div class="cycle-slideshow" data-cycle-fx="fade" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-9" data-cycle-prev="#ss_prev_cav9" data-cycle-next="#ss_next_cav9" data-cycle-slides="div.big_thumb_cust_container" data-index=9 ><div class="big_thumb_cust_container"> <a href="/products/recombinant-human-il-4-cho-expressed-protein-cf_6507-il-cf" title="Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. The ED50 for this effect is 0.05-0.2 ng/mL." class="cust_viewed_9" > <img loading="lazy" src="https://images.novusbio.com/images/protein/6507-ilcf_recombinant-human-il-4-cho-expressed-protein-cf-bioactivity-272020133214.jpg" alt="Bioactivity IL-4 [Unconjugated]" class="big_thumb" /> </a> </div></div><div class="one_image"></div><div class="one_image_11"></div></div> <div class="ds_info"> <div class="tiny"> <a href="/products/recombinant-human-il-4-cho-expressed-protein-cf_6507-il-cf#PublicationSection"> <div class="sprite_pubBook"></div> (3 Publications</a>) </div><div class="tiny"><strong>Species:</strong> Hu</div><div class="tiny"><strong>Applications:</strong> BA</div> </div> </div> </div></div><div class="ds_cav_group"> <div class="ds_cav_block"> <div class="ds_cav_upper" data-catnums="247-ILB"> <div class="name"> <div class="flourish_left"></div> <div class="flourish_right"></div> <a href="/products/recombinant-human-il-15-protein_247-ilb" style="overflow: hidden; width: 280px;" title="IL-15 [Unconjugated]">IL-15<br> [Unconjugated]</a>    </div><div class="sub-header">247-ILB</div> <div class="images_customers"><div class="one_image_l"></div><div class="cycle-slideshow" data-cycle-fx="fade" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-10" data-cycle-prev="#ss_prev_cav10" data-cycle-next="#ss_next_cav10" data-cycle-slides="div.big_thumb_cust_container" data-index=10 ><div class="big_thumb_cust_container"> <a href="/products/recombinant-human-il-15-protein_247-ilb" title="Recombinant Human IL-5 Protein (Catalog # 247-ILB) has a molecular weight (MW) of 13.1 kDa as analyzed by SEC-MALS, suggesting that this protein is a monomer. " class="cust_viewed_10" > <img loading="lazy" src="https://images.novusbio.com/images/247-ilb_recombinant-human-il-15-protein-sec-mals-2922024964..jpg" alt="SEC-MALS IL-15 [Unconjugated]" class="big_thumb" /> </a> </div></div><div class="one_image"></div><div class="one_image_11"></div></div> <div class="ds_info"> <div class="tiny"> <a href="/products/recombinant-human-il-15-protein_247-ilb#PublicationSection"> <div class="sprite_pubBook"></div> (166 Publications</a>) </div><div class="tiny"><strong>Species:</strong> Hu</div><div class="tiny"><strong>Applications:</strong> BA</div> </div> </div> </div> <div class="ds_cav_block"> <div class="ds_cav_upper" data-catnums="DY1335B"> <div class="name"> <div class="flourish_left"></div> <div class="flourish_right"></div> <a href="/products/human-il-17f-duoset-elisa-15-plate_dy1335b" style="overflow: hidden; width: 280px;" title="IL-17F [Biotin]">IL-17F [Biotin]</a>    </div><div class="sub-header">DY1335B</div> <div class="images_customers"><div id="ss_prev_cav11" class="cycle-pager"> <div class="pager_left_on"></div></div><div class="cycle-slideshow" data-cycle-fx="fade" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-11" data-cycle-prev="#ss_prev_cav11" data-cycle-next="#ss_next_cav11" data-cycle-slides="div.big_thumb_cust_container" data-index=11 ><div class="big_thumb_cust_container"> <a href="/products/human-il-17f-duoset-elisa-15-plate_dy1335b" title="" class="cust_viewed_11" > <img loading="lazy" src="https://images.novusbio.com/images2/DATA_IL17F_DY1335_ELISA_2300.jpg" alt="N/A IL-17F [Biotin]" class="big_thumb" /> </a> </div><div class="big_thumb_cust_container"> <a href="/products/human-il-17f-duoset-elisa-15-plate_dy1335b" title="" class="cust_viewed_11" > <img loading="lazy" src="https://images.novusbio.com/images2/DATA_IL17F_DY1335_ELISA_1626.jpg" alt="N/A IL-17F [Biotin]" class="big_thumb" /> </a> </div></div><div id="ss_next_cav11" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-11" class="cycle-circle-pager"></div></div> <div class="ds_info"> <div class="tiny"> <a href="/products/human-il-17f-duoset-elisa-15-plate_dy1335b#PublicationSection"> <div class="sprite_pubBook"></div> (13 Publications</a>) </div><div class="tiny"><strong>Species:</strong> Hu</div><div class="tiny"><strong>Applications:</strong> ELISA</div> </div> </div> </div></div><div class="ds_cav_group"> <div class="ds_cav_block"> <div class="ds_cav_upper" data-catnums="285-IF"> <div class="name"> <div class="flourish_left"></div> <div class="flourish_right"></div> <a href="/products/recombinant-human-ifn-gamma-protein_285-if" style="overflow: hidden; width: 280px;" title="IFN-gamma [Unconjugated]">IFN-gamma<br> [Unconjugated]</a>    </div><div class="sub-header">285-IF</div> <div class="images_customers"><div id="ss_prev_cav12" class="cycle-pager"> <div class="pager_left_on"></div></div><div class="cycle-slideshow" data-cycle-fx="fade" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-12" data-cycle-prev="#ss_prev_cav12" data-cycle-next="#ss_next_cav12" data-cycle-slides="div.big_thumb_cust_container" data-index=12 ><div class="big_thumb_cust_container"> <a href="/products/recombinant-human-ifn-gamma-protein_285-if" title="Recombinant Human IFN-gamma (Catalog # 285‑IF) demonstrates anti-viral activity in HeLa human cervical epithelial carcinoma cells infected with encephalomyocarditis (EMC) virus. The activity is over 2-fold greater than the top competitor's IFN-gamma ." class="cust_viewed_12" > <img loading="lazy" src="https://images.novusbio.com/images2/IFNgamma_285IF_2848.jpg" alt="Bioactivity IFN-gamma [Unconjugated]" class="big_thumb" /> </a> </div><div class="big_thumb_cust_container"> <a href="/products/recombinant-human-ifn-gamma-protein_285-if" title="1 μg/lane of Recombinant Human IFN-gamma was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 17 kDa." class="cust_viewed_12" > <img loading="lazy" src="https://images.novusbio.com/images2/IFN-gamma_285-IF_230.jpg" alt="SDS-PAGE IFN-gamma [Unconjugated]" class="big_thumb" /> </a> </div><div class="big_thumb_cust_container"> <a href="/products/recombinant-human-ifn-gamma-protein_285-if" title="Recombinant Human IFN-gamma (Catalog # 285-IF) has a molecular weight (MW) of 34.9 kDa as analyzed by SEC-MALS, suggesting that this protein is a homodimer. MW may differ from predicted MW due to post-translational modifications (PTMs) present (i.e. Glycosylation)." class="cust_viewed_12" > <img loading="lazy" src="https://images.novusbio.com/images/285-if_recombinant-human-ifn-gamma-protein-sec-mals-1520239228..jpg" alt="SEC-MALS IFN-gamma [Unconjugated]" class="big_thumb" /> </a> </div></div><div id="ss_next_cav12" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-12" class="cycle-circle-pager"></div></div> <div class="ds_info"> <div class="tiny"> <a href="/products/recombinant-human-ifn-gamma-protein_285-if#ReviewsSection"> <div class="sprite_5Stars"></div> (2 Reviews</a>) </div> <div class="tiny"> <a href="/products/recombinant-human-ifn-gamma-protein_285-if#PublicationSection"> <div class="sprite_pubBook"></div> (458 Publications</a>) </div><div class="tiny"><strong>Species:</strong> Hu</div><div class="tiny"><strong>Applications:</strong> BA</div> </div> </div> </div> <div class="ds_cav_block"> <div class="ds_cav_upper" data-catnums="DY1975"> <div class="name"> <div class="flourish_left"></div> <div class="flourish_right"></div> <a href="/products/human-il-37-il-1f7-duoset-elisa-15-plate_dy1975" style="overflow: hidden; width: 280px;" title="IL-37/IL-1F7 [Biotin]">IL-37/IL-1F7<br> [Biotin]</a>    </div><div class="sub-header">DY1975</div> <div class="images_customers"><div class="one_image_l"></div><div class="cycle-slideshow" data-cycle-fx="fade" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-13" data-cycle-prev="#ss_prev_cav13" data-cycle-next="#ss_next_cav13" data-cycle-slides="div.big_thumb_cust_container" data-index=13 ><div class="big_thumb_cust_container"> <a href="/products/human-il-37-il-1f7-duoset-elisa-15-plate_dy1975" title="" class="cust_viewed_13" > <img loading="lazy" src="https://images.novusbio.com/images2/DATA_IL37_DY1975_ELISA_1742.jpg" alt="N/A IL-37/IL-1F7 [Biotin]" class="big_thumb" /> </a> </div></div><div class="one_image"></div><div class="one_image_11"></div></div> <div class="ds_info"> <div class="tiny"> <a href="/products/human-il-37-il-1f7-duoset-elisa-15-plate_dy1975#PublicationSection"> <div class="sprite_pubBook"></div> (13 Publications</a>) </div><div class="tiny"><strong>Species:</strong> Hu</div><div class="tiny"><strong>Applications:</strong> ELISA</div> </div> </div> </div></div><div class="ds_cav_group"> <div class="ds_cav_block"> <div class="ds_cav_upper" data-catnums="AF1375"> <div class="name"> <div class="flourish_left"></div> <div class="flourish_right"></div> <a href="/products/il-26-ak155-antibody_af1375" style="overflow: hidden; width: 280px;" title="IL-26/AK155 Antibody">IL-26/AK155<br> Antibody</a>    </div><div class="sub-header">AF1375</div> <div class="images_customers"><div class="one_image_l"></div><div class="cycle-slideshow" data-cycle-fx="fade" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-14" data-cycle-prev="#ss_prev_cav14" data-cycle-next="#ss_next_cav14" data-cycle-slides="div.big_thumb_cust_container" data-index=14 ><div class="big_thumb_cust_container"> <a href="/products/il-26-ak155-antibody_af1375" title="IL-26/AK155 Antibody" class="cust_viewed_14"> <img loading="lazy" src="/sites/all/modules/enterprise-tech/et_datasheets/images/novus_guarantee.png" alt="IL-26/AK155 Antibody" title="IL-26/AK155 Antibody" class=" big_thumb" /> </a> </div></div><div class="one_image"></div><div class="one_image_11"></div></div> <div class="ds_info"> <div class="tiny"> <a href="/products/il-26-ak155-antibody_af1375#PublicationSection"> <div class="sprite_pubBook"></div> (6 Publications</a>) </div><div class="tiny"><strong>Species:</strong> Hu</div><div class="tiny"><strong>Applications:</strong> WB</div> </div> </div> </div> <div class="ds_cav_block"> <div class="ds_cav_upper" data-catnums="NBP1-49045"> <div class="name"> <div class="flourish_left"></div> <div class="flourish_right"></div> <a href="/products/cd8-antibody-53-67_nbp1-49045" style="overflow: hidden; width: 280px;" title="CD8 Antibody (53-6.7) - BSA Free">CD8 Antibody<br> (53-6.7) - BSA Free</a>    </div><div class="sub-header">NBP1-49045</div> <div class="images_customers"><div id="ss_prev_cav15" class="cycle-pager"> <div class="pager_left_on"></div></div><div class="cycle-slideshow" data-cycle-fx="fade" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-15" data-cycle-prev="#ss_prev_cav15" data-cycle-next="#ss_next_cav15" data-cycle-slides="div.big_thumb_cust_container" data-index=15 ><div class="big_thumb_cust_container"> <a href="/products/cd8-antibody-53-67_nbp1-49045" title="Immunohistochemistry-Paraffin: CD8 Antibody (53-6.7) [NBP1-49045] - CD8 alpha Antibody (53-6.7) [NBP1-49045] - CD8 alpha expression in mouse spleen tissue using anti-CD8 alpha antibody. Image from verified customer review." class="cust_viewed_15" > <img loading="lazy" src="https://images.novusbio.com/images/CD8-Antibody-53-6-7-Immunohistochemistry-Paraffin-NBP1-49045-img0004.jpg" alt="Immunohistochemistry-Paraffin CD8 Antibody (53-6.7) - BSA Free" class="big_thumb" /> </a> </div><div class="big_thumb_cust_container"> <a href="/products/cd8-antibody-53-67_nbp1-49045" title="Immunocytochemistry/Immunofluorescence: CD8 Antibody (53-6.7) [NBP1-49045] - CD8 alpha Antibody (53-6.7) [NBP1-49045] - Analysis of bone marrow tissue by single and multiple staining." class="cust_viewed_15" > <img loading="lazy" src="https://images.novusbio.com/images/CD8-Antibody-53-6-7-Immunocytochemistry-Immunofluorescence-NBP1-49045-img0006.jpg" alt="Immunocytochemistry/ Immunofluorescence CD8 Antibody (53-6.7) - BSA Free" class="big_thumb" /> </a> </div><div class="big_thumb_cust_container"> <a href="/products/cd8-antibody-53-67_nbp1-49045" title="Immunohistochemistry-Frozen: CD8 Antibody (53-6.7) [NBP1-49045] - CD8 alpha Antibody (53-6.7) [NBP1-49045] - Analysis of mosue spleen sections. CD8+ lymphocytes are marked by brown labeling of the cell surface." class="cust_viewed_15" > <img loading="lazy" src="https://images.novusbio.com/images/CD8-Antibody-53-6-7-Immunohistochemistry-Frozen-NBP1-49045-img0008.jpg" alt="Immunohistochemistry-Frozen CD8 Antibody (53-6.7) - BSA Free" class="big_thumb" /> </a> </div></div><div id="ss_next_cav15" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-15" class="cycle-circle-pager"></div></div> <div class="ds_info"> <div class="tiny"> <a href="/products/cd8-antibody-53-67_nbp1-49045#ReviewsSection"> <div class="sprite_4Stars"></div> (3 Reviews</a>) </div> <div class="tiny"> <a href="/products/cd8-antibody-53-67_nbp1-49045#PublicationSection"> <div class="sprite_pubBook"></div> (28 Publications</a>) </div><div class="tiny"><strong>Species:</strong> Mu, Rt</div><div class="tiny"><strong>Applications:</strong> Cell Depl, CyTOF-ready, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, InhibTFunc</div> </div> </div> </div></div><div class="ds_cav_group"> <div class="ds_cav_block"> <div class="ds_cav_upper" data-catnums="207-IL"> <div class="name"> <div class="flourish_left"></div> <div class="flourish_right"></div> <a href="/products/recombinant-human-il-7-protein_207-il" style="overflow: hidden; width: 280px;" title="IL-7 [Unconjugated]">IL-7 [Unconjugated]</a>    </div><div class="sub-header">207-IL</div> <div class="images_customers"><div class="one_image_l"></div><div class="cycle-slideshow" data-cycle-fx="fade" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-16" data-cycle-prev="#ss_prev_cav16" data-cycle-next="#ss_next_cav16" data-cycle-slides="div.big_thumb_cust_container" data-index=16 ><div class="big_thumb_cust_container"> <a href="/products/recombinant-human-il-7-protein_207-il" title="Recombinant Human IL-7 Protein (Catalog # 207-IL) has a molecular weight (MW) of 16.0 kDa as analyzed by SEC-MALS, suggesting that this protein is a monomer." class="cust_viewed_16" > <img loading="lazy" src="https://images.novusbio.com/images/207-il_recombinant-human-il-7-protein-sec-mals-123202493447..jpg" alt="SEC-MALS IL-7 [Unconjugated]" class="big_thumb" /> </a> </div></div><div class="one_image"></div><div class="one_image_11"></div></div> <div class="ds_info"> <div class="tiny"> <a href="/products/recombinant-human-il-7-protein_207-il#PublicationSection"> <div class="sprite_pubBook"></div> (157 Publications</a>) </div><div class="tiny"><strong>Species:</strong> Hu</div><div class="tiny"><strong>Applications:</strong> BA</div> </div> </div> </div> <div class="ds_cav_block"> <div class="ds_cav_upper" data-catnums="AF1709"> <div class="name"> <div class="flourish_left"></div> <div class="flourish_right"></div> <a href="/products/il-17b-antibody_af1709" style="overflow: hidden; width: 280px;" title="IL-17B Antibody [Unconjugated]">IL-17B Antibody<br> [Unconjugated]</a>    </div><div class="sub-header">AF1709</div> <div class="images_customers"><div class="one_image_l"></div><div class="cycle-slideshow" data-cycle-fx="fade" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-17" data-cycle-prev="#ss_prev_cav17" data-cycle-next="#ss_next_cav17" data-cycle-slides="div.big_thumb_cust_container" data-index=17 ><div class="big_thumb_cust_container"> <a href="/products/il-17b-antibody_af1709" title="M‑NFS‑60 mouse myelogenous leukemia lymphoblast cell line was stained with Goat Anti-Mouse IL‑17B Antigen Affinity-purified Polyclonal Antibody (Catalog&amp;nbsp;# AF1709, filled histogram) or isotype control antibody (Catalog&amp;nbsp;# AB‑108‑C, open histogram), followed by Allophycocyanin-conjugated Anti-Goat IgG Secondary Antibody (Catalog&amp;nbsp;# F0108). To facilitate intracellular&amp;nbsp;staining, cells&amp;nbsp;were&amp;nbsp;fixed&amp;nbsp;with paraformaldehyde&amp;nbsp;and permeabilized&amp;nbsp;with&amp;nbsp;saponin." class="cust_viewed_17" > <img loading="lazy" src="https://images.novusbio.com/images2/IL-17B_AF1709_Flow_Cytometry_8161.jpg" alt="Intracellular Staining by Flow Cytometry IL-17B Antibody [Unconjugated]" class="big_thumb" /> </a> </div></div><div class="one_image"></div><div class="one_image_11"></div></div> <div class="ds_info"> <div class="tiny"> <a href="/products/il-17b-antibody_af1709#PublicationSection"> <div class="sprite_pubBook"></div> (2 Publications</a>) </div><div class="tiny"><strong>Species:</strong> Mu</div><div class="tiny"><strong>Applications:</strong> Block, CyTOF-ready, ELISA(Cap), ELISA(Det), ELISA(Sta), ICFlow, WB</div> </div> </div> </div></div><div class="ds_cav_group"> <div class="ds_cav_block"> <div class="ds_cav_upper" data-catnums="1102-IL/CF"> <div class="name"> <div class="flourish_left"></div> <div class="flourish_right"></div> <a href="/products/recombinant-human-il-20-protein-cf_1102-il-cf" style="overflow: hidden; width: 280px;" title="IL-20 [Unconjugated]">IL-20<br> [Unconjugated]</a>    </div><div class="sub-header">1102-IL/CF</div> <div class="images_customers"><div class="one_image_l"></div><div class="cycle-slideshow" data-cycle-fx="fade" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-18" data-cycle-prev="#ss_prev_cav18" data-cycle-next="#ss_next_cav18" data-cycle-slides="div.big_thumb_cust_container" data-index=18 ><div class="big_thumb_cust_container"> <a href="/products/recombinant-human-il-20-protein-cf_1102-il-cf" title="IL-20 [Unconjugated]" class="cust_viewed_18"> <img loading="lazy" src="/sites/all/modules/enterprise-tech/et_datasheets/images/novus_guarantee.png" alt="IL-20 [Unconjugated]" title="IL-20 [Unconjugated]" class=" big_thumb" /> </a> </div></div><div class="one_image"></div><div class="one_image_11"></div></div> <div class="ds_info"> <div class="tiny"> <a href="/products/recombinant-human-il-20-protein-cf_1102-il-cf#PublicationSection"> <div class="sprite_pubBook"></div> (11 Publications</a>) </div><div class="tiny"><strong>Species:</strong> Hu</div><div class="tiny"><strong>Applications:</strong> BA</div> </div> </div> </div> <div class="ds_cav_block"> <div class="ds_cav_upper" data-catnums="NBP2-24503"> <div class="name"> <div class="flourish_left"></div> <div class="flourish_right"></div> <a href="/products/ror-gamma-rorc-nr1f3-antibody_nbp2-24503" style="overflow: hidden; width: 280px;" title="ROR gamma/RORC/NR1F3 Antibody - BSA Free">ROR<br> gamma/RORC/NR1F3 Anti ...</a>    </div><div class="sub-header">NBP2-24503</div> <div class="images_customers"><div id="ss_prev_cav19" class="cycle-pager"> <div class="pager_left_on"></div></div><div class="cycle-slideshow" data-cycle-fx="fade" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-19" data-cycle-prev="#ss_prev_cav19" data-cycle-next="#ss_next_cav19" data-cycle-slides="div.big_thumb_cust_container" data-index=19 ><div class="big_thumb_cust_container"> <a href="/products/ror-gamma-rorc-nr1f3-antibody_nbp2-24503" title="Immunohistochemistry-Paraffin: ROR gamma/RORC/NR1F3 Antibody [NBP2-24503] - Analysis of human testis using NBP2-24503." class="cust_viewed_19" > <img loading="lazy" src="https://images.novusbio.com/images/ROR-gamma-RORC-NR1F3-Antibody-Immunohistochemistry-Paraffin-NBP2-24503-img0003.jpg" alt="Immunohistochemistry-Paraffin ROR gamma/RORC/NR1F3 Antibody - BSA Free" class="big_thumb" /> </a> </div><div class="big_thumb_cust_container"> <a href="/products/ror-gamma-rorc-nr1f3-antibody_nbp2-24503" title="Western Blot: ROR gamma/RORC/NR1F3 Antibody [NBP2-24503] - Analysis of human ROR gamma/RORC/NR1F3 in Jurkat cell lysate in the 1) absence, 2) presence of immunizing peptide, 3) in 3T3, and 4) in RAW cell lysate using NBP2-24503." class="cust_viewed_19" > <img loading="lazy" src="https://images.novusbio.com/images/ROR-gamma-RORC-NR1F3-Antibody-Western-Blot-NBP2-24503-img0004.jpg" alt="Western Blot ROR gamma/RORC/NR1F3 Antibody - BSA Free" class="big_thumb" /> </a> </div><div class="big_thumb_cust_container"> <a href="/products/ror-gamma-rorc-nr1f3-antibody_nbp2-24503" title="Immunocytochemistry/Immunofluorescence: ROR gamma/RORC/NR1F3 Antibody [NBP2-24503] - U-2 OS cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X TBS + 0.5% Triton-X100. The cells were incubated with anti-ROR gamma overnight at 4C and detected with an anti-rabbit Dylight 488 (Green). Alpha tubulin (DM1A) NB100-690 was used as a co-stain and detected with an anti-mouse Dylight 550 (Red). Nuclei were counterstained with DAPI (Blue). Cells were imaged using a 40X objective." class="cust_viewed_19" > <img loading="lazy" src="https://images.novusbio.com/images/ROR-gamma-RORC-NR1F3-Antibody-Immunocytochemistry-Immunofluorescence-NBP2-24503-img0005.jpg" alt="Immunocytochemistry/ Immunofluorescence ROR gamma/RORC/NR1F3 Antibody - BSA Free" class="big_thumb" /> </a> </div></div><div id="ss_next_cav19" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-19" class="cycle-circle-pager"></div></div> <div class="ds_info"> <div class="tiny"> <a href="/products/ror-gamma-rorc-nr1f3-antibody_nbp2-24503#ReviewsSection"> <div class="sprite_4Stars"></div> (1 Review</a>) </div> <div class="tiny"> <a href="/products/ror-gamma-rorc-nr1f3-antibody_nbp2-24503#PublicationSection"> <div class="sprite_pubBook"></div> (3 Publications</a>) </div><div class="tiny"><strong>Species:</strong> Hu, Mu</div><div class="tiny"><strong>Applications:</strong> ICC/IF, IHC, IHC-P, IP, WB</div> </div> </div> </div></div> </div><div id="cav_next"><div class="sprite_rightArrow"></div></div> <div class="clear"></div></div> <div class="ds_tab_content equalbottom" id="content_reviews-publications"> <a id="reviews-publications"></a><a id="PublicationSection"></a><h2 class="greyHead2">Publications for IL-22 (782-IL/CF)(65)</h2><div class="ds_info"> <div>We have publications tested in 3 confirmed species: Human, Mouse, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque).<br /><br />We have publications tested in 7 applications: Bioassay, Cell Culture, ELISA (Capture), ELISA (Standard), Stimulation, Surface Plasmon Resonance, Western Blot.<br /><br /><div class="align-right"> <button class="greybutton btn_width" name="novusreview" onclick="window.location='/publications'"; >Submit a Publication</button><br /> </div> </div><div> <div class="filterParent"> <div class="publications_filterList" id="pubapp"> <div class="blueHead">Filter By Application</div><div class="filter_line"> 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- Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)"> <div style="display:inline;">Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)</div> (1)</div><div class="filter_clear" data-type="publication" data-filter="species">All Species</div></div> </div></div> <div class="clear"></div> <div id="publications_list">Showing Publications 1 - <span id="appcnt">10</span> of 65. <a class="pubs_showall">Show All 65 Publications.</a> <a class="pubs_collapse" style="display:none;">Collapse Publications.</a><table class="wide lightPad tablesorter" id="publications_list_table"> <thead> <tr> <th>Publications using 782-IL/CF</th> <th>Applications</th> <th>Species</th> </tr> </thead> <tbody><tr class="lined revfil firstten" data-application="Stimulation" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/36291778" target="_blank" rel="nofollow"> C Maresca, G Di Maggio, C Stolfi, F Laudisi, M Colella, T Pacifico, A Di Grazia, D Di Fusco, D Congiu, AM Guida, G Sica, I Monteleone, G Monteleone Smad7 Sustains Stat3 Expression and Signaling in Colon Cancer Cells Cancers, 2022-10-12;14(20):. 2022-10-12 [PMID: 36291778] (Stimulation, Human) </a></td> <td valign="top">Stimulation</td> <td valign="top">Human</td> </tr><tr class="lined revfil firstten" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/35878340" target="_blank" rel="nofollow"> S Segarra, T Naiken, J Garnier, V Hamon, N Coussay, FX Bernard Enhanced In Vitro Expression of Filaggrin and Antimicrobial Peptides Following Application of Glycosaminoglycans and a Sphingomyelin-Rich Lipid Extract Oncogene, 2022-06-27;9(7):. 2022-06-27 [PMID: 35878340] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil firstten" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/34864058" target="_blank" rel="nofollow"> DJ Carroll, MWN Burns, L Mottram, DC Propheter, A Boucher, GM Lessen, A Kumar, SA Malaker, C Xing, LV Hooper, U Yrlid, JJ Kohler Interleukin-22 regulates B3GNT7 expression to induce fucosylation of glycoproteins in intestinal epithelial cells The Journal of Biological Chemistry, 2021-12-02;0(0):101463. 2021-12-02 [PMID: 34864058] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil firstten" data-application="Stimulation" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/34685616" target="_blank" rel="nofollow"> L Mercurio, M Morelli, C Scarponi, GL Scaglione, S Pallotta, C Albanesi, S Madonna PI3Kdelta Sustains Keratinocyte Hyperproliferation and Epithelial Inflammation: Implications for a Topically Druggable Target in Psoriasis Cells, 2021-10-02;10(10):. 2021-10-02 [PMID: 34685616] (Stimulation, Human) </a></td> <td valign="top">Stimulation</td> <td valign="top">Human</td> </tr><tr class="lined revfil firstten" data-application="Stimulation" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/34685526" target="_blank" rel="nofollow"> F Abdallah, E Henriet, A Suet, A Arar, R Clemençon, JM Malinge, G Lecellier, P Baril, C Pichon miR-21-3p/IL-22 Axes Are Major Drivers of Psoriasis Pathogenesis by Modulating Keratinocytes Proliferation-Survival Balance and Inflammatory Response Cells, 2021-09-26;10(10):. 2021-09-26 [PMID: 34685526] (Stimulation, Human) </a></td> <td valign="top">Stimulation</td> <td valign="top">Human</td> </tr><tr class="lined revfil firstten" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/34020693" target="_blank" rel="nofollow"> HC Hawerkamp, A Domdey, L Radau, P Sewerin, P Oláh, B Homey, S Meller Tofacitinib downregulates antiviral immune defence in keratinocytes and reduces T cell activation Arthritis Research & Therapy, 2021-05-21;23(1):144. 2021-05-21 [PMID: 34020693] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil firstten" data-application="" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/32972460" target="_blank" rel="nofollow"> HK Min, JY Won, BM Kim, KA Lee, SJ Lee, SH Lee, HR Kim, KW Kim Interleukin (IL)-25 suppresses IL-22-induced osteoclastogenesis in rheumatoid arthritis via STAT3 and p38 MAPK/I&amp;kappaB&amp;alpha pathway Arthritis Research & Therapy, 2020-09-23;22(1):222. 2020-09-23 [PMID: 32972460] (Human) </a></td> <td valign="top"></td> <td valign="top">Human</td> </tr><tr class="lined revfil firstten" data-application="Bioassay" data-species="Human, Mouse"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/31817755" target="_blank" rel="nofollow"> EY Kim, HM Noh, B Choi, JE Park, JE Kim, Y Jang, HK Lee, EJ Chang Interleukin-22 Induces the Infiltration of Visceral Fat Tissue by a Discrete Subset of Duffy Antigen Receptor for Chemokine-Positive M2-Like Macrophages in Response to a High Fat Diet Cells, 2019-12-06;8(12):. 2019-12-06 [PMID: 31817755] (Bioassay, Human, Mouse) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human, Mouse</td> </tr><tr class="lined revfil firstten" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/31780871" target="_blank" rel="nofollow"> X Xu, H Fukui, Y Ran, X Wang, Y Inoue, N Ebisudani, H Nishimura, T Tomita, T Oshima, J Watari, H Kiyama, H Miwa The Link between Type III Reg and STAT3-Associated Cytokines in Inflamed Colonic Tissues Mediators Inflamm., 2019-11-06;2019(0):7859460. 2019-11-06 [PMID: 31780871] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil firstten" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/31597930" target="_blank" rel="nofollow"> KD Hebert, N Mclaughlin, M Galeas-Pen, Z Zhang, T Eddens, A Govero, JM Pilewski, JK Kolls, DA Pociask Targeting the IL-22/IL-22BP axis enhances tight junctions and reduces inflammation during influenza infection Mucosal Immunol, 2019-10-09;0(0):. 2019-10-09 [PMID: 31597930] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/31540162" target="_blank" rel="nofollow"> JC Chamcheu, S Esnault, VM Adhami, AL Noll, S Banang-Mbe, T Roy, SS Singh, S Huang, KG Kousoulas, H Mukhtar Fisetin, a 3,7,3&#039;,4&#039;-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models Cells, 2019-09-15;8(9):. 2019-09-15 [PMID: 31540162] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Cell Culture" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/31501002" target="_blank" rel="nofollow"> S Sugihara, S Sugimoto, K Tachibana, M Kobashi, H Nomura, T Miyake, Y Hirai, O Yamasaki, S Morizane TNF-Î± and IL-17A induce the expression of lympho-epithelial Kazal-type inhibitor in epidermal keratinocytes J. Dermatol. Sci., 2019-08-21;0(0):. 2019-08-21 [PMID: 31501002] (Cell Culture, Human) </a></td> <td valign="top">Cell Culture</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Cell Culture" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/31292217" target="_blank" rel="nofollow"> H Lindahl, AO Guerreiro-, SK Bedri, M Linnerbaue, M Lindén, N Abdelmagid, K Tandre, C Hollins, L Irving, C Glover, C Jones, L Alfredsson, L Rönnblom, I Kockum, M Khademi, M Jagodic, T Olsson IL-22 Binding Protein Promotes the Disease Process in Multiple Sclerosis J. Immunol., 2019-07-10;0(0):. 2019-07-10 [PMID: 31292217] (Cell Culture, Human) </a></td> <td valign="top">Cell Culture</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/30894513" target="_blank" rel="nofollow"> S Sun, X Zhang, M Xu, F Zhang, F Tian, J Cui, Y Xia, C Liang, S Zhou, H Wei, H Zhao, G Wu, B Xu, X Liu, G Yang, Q Wang, L Zhang, Y Gong, C Shao, Y Zou Berberine downregulates CDC6 and inhibits proliferation via targeting JAK-STAT3 signaling in keratinocytes Cell Death Dis, 2019-03-20;10(4):274. 2019-03-20 [PMID: 30894513] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/30858525" target="_blank" rel="nofollow"> F Abdallah, G Lecellier, P Raharivelo, C Pichon R. nukuhivensis acts by reinforcing skin barrier function, boosting skin immunity and by inhibiting IL-22 induced keratinocyte hyperproliferation Sci Rep, 2019-03-11;9(1):4132. 2019-03-11 [PMID: 30858525] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/30856602" target="_blank" rel="nofollow"> JE Heath, GM Scholz, PD Veith, EC Reynolds IL-36? regulates mediators of tissue homeostasis in epithelial cells Cytokine, 2019-03-08;119(0):24-31. 2019-03-08 [PMID: 30856602] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/30377293" target="_blank" rel="nofollow"> L Mercurio, M Morelli, C Scarponi, EZ Eisenmesse, N Doti, G Pagnanelli, E Gubinelli, C Mazzanti, A Cavani, M Ruvo, CA Dinarello, C Albanesi, S Madonna IL-38 has an anti-inflammatory action in psoriasis and its expression correlates with disease severity and therapeutic response to anti-IL-17A treatment Cell Death Dis, 2018-10-30;9(11):1104. 2018-10-30 [PMID: 30377293] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/30185657" target="_blank" rel="nofollow"> M Abikhair B, N Roudiani, J Chen, AL Santana, N Doudican, C Proby, D Felsen, JA Carucci Ruxolitinib inhibits cyclosporine-induced proliferation of cutaneous squamous cell carcinoma JCI Insight, 2018-09-06;3(17):. 2018-09-06 [PMID: 30185657] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Cell Culture" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/29655629" target="_blank" rel="nofollow"> BA Stanfield, PJF Rider, J Caskey, F Del Piero, KG Kousoulas Intramuscular vaccination of guinea pigs with the live-attenuated human herpes simplex vaccine VC2 stimulates a transcriptional profile of vaginal Th17 and regulatory Tr1 responses Vaccine, 2018-04-11;0(0):. 2018-04-11 [PMID: 29655629] (Cell Culture, Human) </a></td> <td valign="top">Cell Culture</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Cell Culture" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/29371118" target="_blank" rel="nofollow"> L Bin, X Li, B Richers, JE Streib, JW Hu, P Taylor, DYM Leung ANKRD1 regulates innate immune responses against herpes simplex virus 1: A potential role in eczema herpeticum J. Allergy Clin. Immunol., 2018-01-31;0(0):. 2018-01-31 [PMID: 29371118] (Cell Culture, Human) </a></td> <td valign="top">Cell Culture</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/29336866" target="_blank" rel="nofollow"> S Sawamura, M Jinnin, K Inoue, K Yamane, N Honda, I Kajihara, T Makino, S Masuguchi, S Fukushima, H Ihn Regulatory mechanisms of collagen expression by interleukin-22 signaling in scleroderma fibroblasts J. Dermatol. Sci., 2017-12-29;0(0):. 2017-12-29 [PMID: 29336866] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/29330151" target="_blank" rel="nofollow"> S Abadpour, B Halvorsen, A Sahraoui, O Korsgren, P Aukrust, H Scholz Interleukin-22 reverses human islet dysfunction and apoptosis triggered by hyperglycemia and LIGHT J. Mol. Endocrinol., 2018-01-12;0(0):. 2018-01-12 [PMID: 29330151] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Mouse"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/29150834" target="_blank" rel="nofollow"> R Bichele, J Kärner, K Truusalu, I Smidt, R Mändar, HR Conti, SL Gaffen, P Peterson, M Laan, K Kisand IL-22 neutralizing autoantibodies impair fungal clearance in murine oropharyngeal candidiasis model Eur. J. Immunol., 2017-12-11;0(0):. 2017-12-11 [PMID: 29150834] (Bioassay, Mouse) </a></td> <td valign="top">Bioassay</td> <td valign="top">Mouse</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/28939759" target="_blank" rel="nofollow"> Y Wang, JB Mumm, R Herbst, R Kolbeck, Y Wang IL-22 Increases Permeability of Intestinal Epithelial Tight Junctions by Enhancing Claudin-2 Expression J. Immunol., 2017-09-22;0(0):. 2017-09-22 [PMID: 28939759] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/28901004" target="_blank" rel="nofollow"> M Tohyama, Y Shirakata, Y Hanakawa, X Dai, K Shiraishi, M Murakami, S Miyawaki, H Mori, R Utsunomiya, K Masuda, K Hashimoto, K Sayama Bcl-3 induced by IL-22 via STAT3 activation acts as a potentiator of psoriasis-related gene expression in epidermal keratinocytes Eur. J. Immunol., 2017-11-20;0(0):. 2017-11-20 [PMID: 28901004] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/28708859" target="_blank" rel="nofollow"> E Couderc, F Morel, P Levillain, A Buffière-M, M Camus, C Paquier, C Bodet, JF Jégou, M Pohin, L Favot, M Garcia, V Huguier, J Mcheik, C Lacombe, H Yssel, G Guillet, FX Bernard, JC Lecron Interleukin-17A-induced production of acute serum amyloid A by keratinocytes contributes to psoriasis pathogenesis PLoS ONE, 2017-07-14;12(7):e0181486. 2017-07-14 [PMID: 28708859] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/28558005" target="_blank" rel="nofollow"> Y Kim, J Lee, J Kim, CW Choi, YI Hwang, JS Kang, WJ Lee The pathogenic role of interleukin-22 and its receptor during UVB-induced skin inflammation PLoS ONE, 2017-05-30;12(5):e0178567. 2017-05-30 [PMID: 28558005] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay, Surface Plasmon Resonance" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/28479106" target="_blank" rel="nofollow"> S La Manna, PL Scognamigl, C Di Natale, M Leone, FA Mercurio, AM Malfitano, F Cianfarani, S Madonna, S Caravella, C Albanesi, E Novellino, D Marasco Characterization of linear mimetic peptides of Interleukin-22 from dissection of protein interfaces Biochimie, 2017-05-04;0(0):. 2017-05-04 [PMID: 28479106] (Bioassay, Surface Plasmon Resonance, Human) </a></td> <td valign="top">Bioassay, Surface Plasmon Resonance</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="ELISA (Standard)" data-species=""> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/28318629" target="_blank" rel="nofollow"> J Zhang, IM Friberg, A Kift-Morga, G Parekh, MP Morgan, AR Liuzzi, CY Lin, KL Donovan, CS Colmont, PH Morgan, P Davis, I Weeks, DJ Fraser, N Topley, M Eberl Machine-learning algorithms define pathogen-specific local immune fingerprints in peritoneal dialysis patients with bacterial infections Kidney Int, 2017-03-17;0(0):. 2017-03-17 [PMID: 28318629] (ELISA (Standard)) </a></td> <td valign="top">ELISA (Standard)</td> <td valign="top"></td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/28289191" target="_blank" rel="nofollow"> JS Ainscough, T Macleod, D McGonagle, R Brakefield, JM Baron, A Alase, M Wittmann, M Stacey Cathepsin S is the major activator of the psoriasis-associated proinflammatory cytokine IL-36? Proc. Natl. Acad. Sci. U.S.A, 2017-03-13;114(13):E2748-E2757. 2017-03-13 [PMID: 28289191] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/27843200" target="_blank" rel="nofollow"> Robert Sabat MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic Alterations Mediators Inflamm., 2016-10-23;2016(0):4097574. 2016-10-23 [PMID: 27843200] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/27664279" target="_blank" rel="nofollow"> JAK2 Disease-Risk Variants Are Gain of Function and JAK Signaling Threshold Determines Innate Receptor-Induced Proinflammatory Cytokine Secretion in Macrophages J Immunol, 2016-09-23;0(0):. 2016-09-23 [PMID: 27664279] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/27588419" target="_blank" rel="nofollow"> Impaired Tight Junctions in Atopic Dermatitis Skin and in a Skin-Equivalent Model Treated with Interleukin-17 PLoS ONE, 2016-09-02;11(9):e0161759. 2016-09-02 [PMID: 27588419] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/27166675" target="_blank" rel="nofollow"> The Role of Interleukin-22 and Its Receptor in the Development and Pathogenesis of Experimental Autoimmune Uveitis PLoS ONE, 2016-05-11;11(5):e0154904. 2016-05-11 [PMID: 27166675] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/27067635" target="_blank" rel="nofollow"> OB Corneth, RM Reijmers, AM Mus, PS Asmawidjaj, JP van Hambur, N Papazian, JY Siegers, F Mourcin, R Amin, K Tarte, RW Hendriks, T Cupedo, E Lubberts Loss of IL-22 inhibits autoantibody formation in collagen-induced arthritis in mice Eur J Immunol, 2016-05-12;0(0):. 2016-05-12 [PMID: 27067635] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/26077779" target="_blank" rel="nofollow"> Perriard G, Mathias A, Enz L, Canales M, Schluep M, Gentner M, Schaeren-Wiemers N, Du Pasquier R Interleukin-22 is increased in multiple sclerosis patients and targets astrocytes. J Neuroinflammation, 2015-06-16;12(0):119. 2015-06-16 [PMID: 26077779] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/25793261" target="_blank" rel="nofollow"> Akil H, Abbaci A, Lalloue F, Bessette B, Costes L, Domballe L, Charreau S, Guilloteau K, Karayan-Tapon L, Bernard F, Morel F, Jauberteau M, Lecron J IL22/IL-22R pathway induces cell survival in human glioblastoma cells. PLoS ONE, 2015-03-20;10(3):e0119872. 2015-03-20 [PMID: 25793261] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/25659101" target="_blank" rel="nofollow"> Banas M, Zegar A, Kwitniewski M, Zabieglo K, Marczynska J, Kapinska-Mrowiecka M, LaJevic M, Zabel B, Cichy J The expression and regulation of chemerin in the epidermis. PLoS ONE, 2015-02-06;10(2):e0117830. 2015-02-06 [PMID: 25659101] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/25604685" target="_blank" rel="nofollow"> Sugita S, Kamao H, Iwasaki Y, Okamoto S, Hashiguchi T, Iseki K, Hayashi N, Mandai M, Takahashi M Inhibition of T-cell activation by retinal pigment epithelial cells derived from induced pluripotent stem cells. Invest Ophthalmol Vis Sci, 2015-01-20;56(2):1051-62. 2015-01-20 [PMID: 25604685] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/25174402" target="_blank" rel="nofollow"> De Simone V, Franze E, Ronchetti G, Colantoni A, Fantini M, Di Fusco D, Sica G, Sileri P, MacDonald T, Pallone F, Monteleone G, Stolfi C Th17-type cytokines, IL-6 and TNF-alpha synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth. Oncogene, 2014-09-01;34(27):3493-503. 2014-09-01 [PMID: 25174402] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/25141829" target="_blank" rel="nofollow"> Shen H, Wang Y, Chen C, Frencher J, Huang D, Yang E, Ryan-Payseur B, Chen Z Th17-related cytokines contribute to recall-like expansion/effector function of HMBPP-specific Vgamma2Vdelta2 T cells after Mycobacterium tuberculosis infection or vaccination. Eur J Immunol, 2015-02-01;45(2):442-51. 2015-02-01 [PMID: 25141829] (Bioassay, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)) </a></td> <td valign="top">Bioassay</td> <td valign="top">Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/25010647" target="_blank" rel="nofollow"> Rabeony H, Petit-Paris I, Garnier J, Barrault C, Pedretti N, Guilloteau K, Jegou J, Guillet G, Huguier V, Lecron J, Bernard F, Morel F Inhibition of keratinocyte differentiation by the synergistic effect of IL-17A, IL-22, IL-1alpha, TNFalpha and oncostatin M. PLoS ONE, 2014-07-10;9(7):e101937. 2014-07-10 [PMID: 25010647] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/25002577" target="_blank" rel="nofollow"> Sakaguchi M, Murata H, Aoyama Y, Hibino T, Putranto E, Ruma I, Inoue Y, Sakaguchi Y, Yamamoto K, Kinoshita R, Futami J, Kataoka K, Iwatsuki K, Huh N DNAX-activating protein 10 (DAP10) membrane adaptor associates with receptor for advanced glycation end products (RAGE) and modulates the RAGE-triggered signaling pathway in human keratinocytes. J Biol Chem, 2014-07-07;289(34):23389-402. 2014-07-07 [PMID: 25002577] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/24824519" target="_blank" rel="nofollow"> Chen J, Wu M, Kuo S, Liao F IL-22 negatively regulates Helicobacter pylori-induced CCL20 expression in gastric epithelial cells. PLoS ONE, 2014-05-13;9(5):e97350. 2014-05-13 [PMID: 24824519] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Western Blot" data-species=""> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/24710357" target="_blank" rel="nofollow"> Beigel F, Friedrich M, Probst C, Sotlar K, Goke B, Diegelmann J, Brand S Oncostatin M mediates STAT3-dependent intestinal epithelial restitution via increased cell proliferation, decreased apoptosis and upregulation of SERPIN family members. PLoS ONE, 2014-04-07;9(4):e93498. 2014-04-07 [PMID: 24710357] (Western Blot) </a></td> <td valign="top">Western Blot</td> <td valign="top"></td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/23592500" target="_blank" rel="nofollow"> Madonna S, Scarponi C, Doti N, Carbone T, Cavani A, Scognamiglio P, Marasco D, Albanesi C Therapeutical potential of a peptide mimicking the SOCS1 kinase inhibitory region in skin immune responses. Eur J Immunol, 2013-05-28;43(7):1883-95. 2013-05-28 [PMID: 23592500] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/23509356" target="_blank" rel="nofollow"> Rosen L, Freeman A, Yang L, Jutivorakool K, Olivier K, Angkasekwinai N, Suputtamongkol Y, Bennett J, Pyrgos V, Williamson P, Ding L, Holland S, Browne S Anti-GM-CSF autoantibodies in patients with cryptococcal meningitis. J Immunol, 2013-03-18;190(8):3959-66. 2013-03-18 [PMID: 23509356] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/23174657" target="_blank" rel="nofollow"> Pennino D, Bhavsar P, Effner R, Avitabile S, Venn P, Quaranta M, Marzaioli V, Cifuentes L, Durham S, Cavani A, Eyerich K, Chung K, Schmidt-Weber C, Eyerich S IL-22 suppresses IFN-gamma-mediated lung inflammation in asthmatic patients. J Allergy Clin Immunol, 2012-11-19;131(2):562-70. 2012-11-19 [PMID: 23174657] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/21993848" target="_blank" rel="nofollow"> Ramirez-Carrozzi V, Sambandam A, Luis E IL-17C regulates the innate immune function of epithelial cells in an autocrine manner. Nat. Immunol., 2011-10-12;12(12):1159-66. 2011-10-12 [PMID: 21993848] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/21345484" target="_blank" rel="nofollow"> Chang Y, Al-Alwan L, Risse PA, Roussel L, Rousseau S, Halayko AJ, Martin JG, Hamid Q, Eidelman DH TH17 cytokines induce human airway smooth muscle cell migration. J. Allergy Clin. Immunol., 2011-02-22;127(4):1046-53.e1-2. 2011-02-22 [PMID: 21345484] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/21242515" target="_blank" rel="nofollow"> Johnston A, Xing X, Guzman AM, Riblett M, Loyd CM, Ward NL, Wohn C, Prens EP, Wang F, Maier LE, Kang S, Voorhees JJ, Elder JT, Gudjonsson JE IL-1F5, -F6, -F8, and -F9: A Novel IL-1 Family Signaling System That Is Active in Psoriasis and Promotes Keratinocyte Antimicrobial Peptide Expression. J. Immunol., 2011-01-17;186(4):2613-22. 2011-01-17 [PMID: 21242515] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/20376066" target="_blank" rel="nofollow"> Gudjonsson JE, Johnston A, Stoll SW Evidence for altered Wnt signaling in psoriatic skin. J. Invest. Dermatol., 2010-04-08;130(7):1849-59. 2010-04-08 [PMID: 20376066] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/20335534" target="_blank" rel="nofollow"> Guilloteau K, Paris I, Pedretti N, Boniface K, Juchaux F, Huguier V, Guillet G, Bernard FX, Lecron JC, Morel F Skin Inflammation Induced by the Synergistic Action of IL-17A, IL-22, Oncostatin M, IL-1alpha, and TNF-alpha Recapitulates Some Features of Psoriasis. J. Immunol., 2010-03-24;184(0):5263-70. 2010-03-24 [PMID: 20335534] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="ELISA (Capture)" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/20123959" target="_blank" rel="nofollow"> Kisand K, Boe Wolff AS, Podkrajsek KT, Tserel L, Link M, Kisand KV, Ersvaer E, Perheentupa J, Erichsen MM, Bratanic N, Meloni A, Cetani F, Perniola R, Ergun-Longmire B, Maclaren N, Krohn KJ, Pura M, Schalke B, Strobel P, Leite MI, Battelino T, Husebye ES, Peterson P, Willcox N, Meager A Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines. J. Exp. Med., 2010-02-01;207(2):299-308. 2010-02-01 [PMID: 20123959] (ELISA (Capture), Human) </a></td> <td valign="top">ELISA (Capture)</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="ELISA (Standard)" data-species=""> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/19895848" target="_blank" rel="nofollow"> Heo YJ, Joo YB, Oh HJ, Park MK, Heo YM, Cho ML, Kwok SK, Ju JH, Park KS, Cho SG, Park SH, Kim HY, Min JK IL-10 suppresses Th17 cells and promotes regulatory T cells in the CD4+ T cell population of rheumatoid arthritis patients. Immunol. Lett., 2009-11-04;127(2):150-6. 2009-11-04 [PMID: 19895848] (ELISA (Standard)) </a></td> <td valign="top">ELISA (Standard)</td> <td valign="top"></td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/19830738" target="_blank" rel="nofollow"> Wolk K, Witte E, Warszawska K, Schulze-Tanzil G, Witte K, Philipp S, Kunz S, Docke WD, Asadullah K, Volk HD, Sterry W, Sabat R The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: a novel immunological cascade with potential relevance in psoriasis. Eur. J. Immunol., 2009-12-01;39(12):3570-81. 2009-12-01 [PMID: 19830738] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/19798076" target="_blank" rel="nofollow"> Witte K, Gruetz G, Volk HD, Looman AC, Asadullah K, Sterry W, Sabat R, Wolk K Despite IFN-lambda receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines. Genes Immun., 2009-10-01;10(8):702-14. 2009-10-01 [PMID: 19798076] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/19731362" target="_blank" rel="nofollow"> Tohyama M, Hanakawa Y, Shirakata Y, Dai X, Yang L, Hirakawa S, Tokumaru S, Okazaki H, Sayama K, Hashimoto K IL-17 and IL-22 mediate IL-20 subfamily cytokine production in cultured keratinocytes via increased IL-22 receptor expression. Eur. J. Immunol., 2009-10-01;39(10):2779-88. 2009-10-01 [PMID: 19731362] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/19056108" target="_blank" rel="nofollow"> Kinoshita H, Takai T, Le TA, Kamijo S, Wang XL, Ushio H, Hara M, Kawasaki J, Vu AT, Ogawa T, Gunawan H, Ikeda S, Okumura K, Ogawa H Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA. J. Allergy Clin. Immunol., 2008-12-03;123(1):179-86. 2008-12-03 [PMID: 19056108] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/18981165" target="_blank" rel="nofollow"> Guttman-Yassky E, Lowes MA, Fuentes-Duculan J, Zaba LC, Cardinale I, Nograles KE, Khatcherian A, Novitskaya I, Carucci JA, Bergman R, Krueger JG Low expression of the IL-23/Th17 pathway in atopic dermatitis compared to psoriasis. J. Immunol., 2008-11-15;181(10):7420-7. 2008-11-15 [PMID: 18981165] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/18264110" target="_blank" rel="nofollow"> Aujla SJ, Chan YR, Zheng M, Fei M, Askew DJ, Pociask DA, Reinhart TA, McAllister F, Edeal J, Gaus K, Husain S, Kreindler JL, Dubin PJ, Pilewski JM, Myerburg MM, Mason CA, Iwakura Y, Kolls JK IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat. Med., 2008-02-10;14(3):275-81. 2008-02-10 [PMID: 18264110] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/18191408" target="_blank" rel="nofollow"> Dambacher J, Beigel F, Zitzmann K, Heeg MH, Goke B, Diepolder HM, Auernhammer CJ, Brand S The role of interleukin-22 in hepatitis C virus infection. Cytokine, 2008-01-11;41(3):209-16. 2008-01-11 [PMID: 18191408] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/17277128" target="_blank" rel="nofollow"> Sa SM, Valdez PA, Wu J The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis. J. Immunol., 2007-02-15;178(4):2229-40. 2007-02-15 [PMID: 17277128] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/16619290" target="_blank" rel="nofollow"> Wolk K, Witte E, Wallace E, Docke WD, Kunz S, Asadullah K, Volk HD, Sterry W, Sabat R IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis. Eur. J. Immunol., 2006-05-01;36(5):1309-23. 2006-05-01 [PMID: 16619290] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/14607900" target="_blank" rel="nofollow"> Herrero C, Hu X, Li WP, Samuels S, Sharif MN, Kotenko S, Ivashkiv LB Reprogramming of IL-10 activity and signaling by IFN-gamma. J. Immunol., 2003-11-15;171(10):5034-41. 2003-11-15 [PMID: 14607900] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr><td colspan="3" align="center"> <a class="pubs_showall">Show All 65 Publications.</a> <a class="pubs_collapse" style="display:none;">Collapse Publications.</a> </td></tr></tbody> </table> </div> </div> <a id="ReviewsSection"></a> <h2 class="greyHead2">Reviews for <span>IL-22 (782-IL/CF) (0) </span></h2> <div class="ds_info"> There are no reviews for IL-22 (782-IL/CF). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount. <br/> <ul> <li>Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen</li> <li>Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen</li> </ul> <div class="align-right"> <a href="/reviews/782-IL/CF"><button class="greybutton btn_width" name="novusreview">Submit a Review</button></a><br /> </div> </div> <div class="clear"></div></div> <div class="ds_tab_content equalbottom" id="content_protocols-faqs"> <a id="protocols-faqs"></a><h2 class="greyHead2">FAQs for IL-22 (782-IL/CF) (0)</h2> <a id="faqs"></a> <div class="ds_info">There are no specific FAQs related to this product. Read our general <a href="/support/faqs.html">customer & technical service FAQs.</a> </div> <div class="clear"></div></div> <div class="ds_tab_content equalbottom" id="content_supportresearch"> <a id="supportresearch"></a><table cellpadding="0" cellspacing="0"><tr></td></tr></table><h2 class="greyHead2">Additional IL-22 Products</h2> <a id="addtlalphaprods"></a> <div class="ds_info"> <div> <span style="display:none;">Array 782-IL/CF</span> <ul class="ds_noDotList"><li> <a href="/primary-antibodies/il-22">IL-22 Antibodies</a></li><li> <a href="/antibody-pairs/il-22">IL-22 Antibody Pair</a></li><li> <a href="/elisa-kits/il-22">IL-22 ELISA Kit</a></li><li> <a href="/lysates/il-22">IL-22 Lysate</a></li><li> <a href="/proteins/il-22">IL-22 Proteins</a></li><li> <a href="/proteins-and-enzymes/il-22">IL-22 Proteins and Enzymes</a></li><li> <a href="/elisas/il-22">IL-22 ELISAs</a></li></ul> </div> </div><table cellpadding="0" cellspacing="0" class="width100"><tr></tr></table><table cellpadding="0" cellspacing="0" class="width100"><tr></tr></table><h2 class="greyHead2">Blogs on IL-22. </h2> <a id="blogsect"></a> <div class="ds_info"><a href="/antibody-news/tag/il-22">Check out the latest blog posts on IL-22</a>.</div> <div class="ds_info"> <table id="blogs_list_table"> <tbody> <tr class=" blogwrap "> <td> <strong><a href="/antibody-news/toll-like-receptors-in-the-intestinal-epithelial-cells">Toll-like receptors in the intestinal epithelial cells</a></strong><br/> <span> By Jamshed Arslan, Pharm. D., PhD. Toll-like receptors (TLRs) are microbe-sensing proteins that act as first responders to danger signals. TLRs help the intestinal epithelial cells (IECs) recognize commensal bacteria ...  <a href="/antibody-news/toll-like-receptors-in-the-intestinal-epithelial-cells">Read full blog post.</a></span><br /><br /> </td> </tr> <tr class=" blogwrap "> <td> <strong><a href="/antibody-news/antibodies/ppar-gamma-an-important-target-in-human-metabolism">PPAR gamma - An important target in human metabolism </a></strong><br/> <span>Peroxisome proliferators are non-genotoxic carcinogens which are purported to exert their effect on cells by interacting with members of the nuclear hormone receptor superfamily known as peroxisome proliferator activated receptors (PPARs). There are f...  <a href="/antibody-news/antibodies/ppar-gamma-an-important-target-in-human-metabolism">Read full blog post.</a></span><br /><br /> </td> </tr></tbody> </table> </div> <div class="clear"></div></div> </div></div><div class="grid_6"><div class="ds_blue_border marTop26 equalbottom"><a id="jump_recommended"></a> <h2 class="greyHead2">Customers Who Bought This Also Bought</h2> <div class="text_center"><div class="images2"><div class="cycle-slideshow" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-prev="#ss_prev_sidebar" data-cycle-next="#ss_next_sidebar" data-cycle-slides="div.big_thumb_container" id="ds_customer_who_bought" ><div class="big_thumb_container" data-catnums="210-TA-005"> <div class="img_container"> <a href="/products/recombinant-human-tnf-alpha-protein_210-ta" title="1 µg/lane of Recombinant Human TNF-alpha was resolved by SDS-PAGE with silver staining, under reducing (R) conditions, showing a band at 17 kDa." class="cust_bought" > <img loading="lazy" src="https://images.novusbio.com/images2/TNF-alpha_210-TA_256.jpg" title="1 µg/lane of Recombinant Human TNF-alpha was resolved by SDS-PAGE with silver staining, under reducing (R) conditions, showing a band at 17 kDa." alt="1 µg/lane of Recombinant Human TNF-alpha was resolved by SDS-PAGE with silver staining, under reducing (R) conditions, showing a band at 17 kDa." class="big_thumb" /> </a> </div> <div class="caption_container"><a href="/products/recombinant-human-tnf-alpha-protein_210-ta">TNF-alpha [Unconjugated]</a> <br />210-TA-005</div> <div style="text-align: right"><button class="greybutton" id="novusviewdatasheet" name="novusviewdatasheet" onclick="window.location='/products/recombinant-human-tnf-alpha-protein_210-ta';" >View Datasheet</button> </div> </div></div></div></div><div class="clear"></div><a id="jump_distributor"></a> <h2 class="greyHead2">Contact Information</h2> <div class="ds_info"> <div id="distributors"></div> </div> <div id="et_reload_trigger" style="display:none;">reload</div><h2 class="greyHead2">Product PDFs</h2><div class="silverHeadShort"> <span class="file"><a href="//aero.bio-techne.com/sds/pdf/782-il/cf" target="_blank" class="sprite_dsPDF"><span class="pdfSmaller"> </span></a></span> <span class="download-file-text" ><a href="//aero.bio-techne.com/sds/pdf/782-il/cf" target="_blank" class="datasheet-download sdsFile">PDF SDS</a></span> </div><div class="silverHeadShort"> <span class="file"><a href="//resources.rndsystems.com/pdfs/datasheets/782-il_cf.pdf" target="_blank" class="sprite_dsPDF"><span class="pdfSmaller"> </span></a></span> <span class="download-file-text" ><a href="//resources.rndsystems.com/pdfs/datasheets/782-il_cf.pdf" target="_blank" class="datasheet-download">PDF Datasheet</a></span> </div><div class="silverHeadShort"> <span class="file"><a href="mailto:novus@novusbio.com?subject=Request%20CofA%20for%20782-IL%2FCF" class="sprite_newDocument"><span class="downloadBlank"> </span></a></span> <span class="download-file-text"><a href="mailto:nb-technical@bio-techne.com?subject=Request%20CofA%20for%20782-IL%2FCF&body=Specific%20catalog%20number(if multiple sizes):%0ALot%20Number:%0AAny%20additional%20products:">Request CofA</a></span> </div><h2 class="greyHead2">Calculators</h2> <div class="calc_wrapper"> <div class="dsSprite_calc"></div> <div class="fake_link" id="calc_reconstitution_link">Concentration Calculator</div> <div id="calc_reconstitution_wrapper" class="calc_function_wrapper"> <div class="calc_popup"> <div class="calc_close"> <div class="dsSprite_calc_close"></div> </div> <div class="calc_header">Concentration Calculator</div> <div id="reconstitution_calculator" class="calculator"> <div class="reconstitution_calculator_text" id="reconstitution_calculator_instructions"> <p>The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. 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