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Health risks</span> </div> </a> <ul id="toc-1._Health_risks-sublist" class="vector-toc-list"> <li id="toc-Unexpected_gene_interactions" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Unexpected_gene_interactions"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.1.1</span> <span>Unexpected gene interactions</span> </div> </a> <ul id="toc-Unexpected_gene_interactions-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Cancer_risks" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Cancer_risks"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.1.2</span> <span>Cancer risks</span> </div> </a> <ul id="toc-Cancer_risks-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Allergenic_potential" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Allergenic_potential"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.1.3</span> <span>Allergenic potential</span> </div> </a> <ul id="toc-Allergenic_potential-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Horizontal_gene_transfer_(HGT)" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Horizontal_gene_transfer_(HGT)"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.1.4</span> <span>Horizontal gene transfer (HGT)</span> </div> </a> <ul id="toc-Horizontal_gene_transfer_(HGT)-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Antibiotic_resistance" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Antibiotic_resistance"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.1.5</span> <span>Antibiotic resistance</span> </div> </a> <ul id="toc-Antibiotic_resistance-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> </ul> </li> <li id="toc-Gain-of-function_mutations" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Gain-of-function_mutations"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Gain-of-function mutations</span> </div> </a> <button aria-controls="toc-Gain-of-function_mutations-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Gain-of-function mutations subsection</span> </button> <ul id="toc-Gain-of-function_mutations-sublist" class="vector-toc-list"> <li id="toc-Research" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Research"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.1</span> <span>Research</span> </div> </a> <ul id="toc-Research-sublist" class="vector-toc-list"> <li id="toc-Mousepox" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Mousepox"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.1.1</span> <span>Mousepox</span> </div> </a> <ul id="toc-Mousepox-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Influenza" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Influenza"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.1.2</span> <span>Influenza</span> </div> </a> <ul id="toc-Influenza-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Regulation" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Regulation"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.2</span> <span>Regulation</span> </div> </a> <ul id="toc-Regulation-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-CRISPR" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#CRISPR"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>CRISPR</span> </div> </a> <ul id="toc-CRISPR-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-See_also" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#See_also"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>See also</span> </div> </a> <ul id="toc-See_also-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>References</span> </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-External_links" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#External_links"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>External links</span> </div> </a> <ul id="toc-External_links-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> 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class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Existential threat from biological sources</div> <p class="mw-empty-elt"> </p><p><b>Biotechnology risk</b> is a form of <a href="/wiki/Existential_risk" class="mw-redirect" title="Existential risk">existential risk</a> from biological sources, such as <a href="/wiki/Genetic_engineering" title="Genetic engineering">genetically engineered</a> biological agents.<sup id="cite_ref-MyUser_Nickbostrom.com_April_3_2016c_1-0" class="reference"><a href="#cite_note-MyUser_Nickbostrom.com_April_3_2016c-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-GCRs_bio-chapter_2-0" class="reference"><a href="#cite_note-GCRs_bio-chapter-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> The release of such high-consequence <a href="/wiki/Pathogen" title="Pathogen">pathogens</a> could be </p> <ul><li>deliberate (in the form of <a href="/wiki/Bioterrorism" title="Bioterrorism">bioterrorism</a> or <a href="/wiki/Biological_weapons" class="mw-redirect" title="Biological weapons">biological weapons</a>)</li> <li>accidental, or</li> <li>a naturally occurring event.</li></ul> <p>A chapter on biotechnology and <a href="/wiki/Biosecurity" title="Biosecurity">biosecurity</a> was included in <a href="/wiki/Nick_Bostrom" title="Nick Bostrom">Nick Bostrom</a>'s 2008 anthology <i><a href="/wiki/Global_Catastrophic_Risks_(book)" title="Global Catastrophic Risks (book)">Global Catastrophic Risks</a></i>, which covered risks including viral agents.<sup id="cite_ref-MyUser_Amazon.com_April_3_2016c_3-0" class="reference"><a href="#cite_note-MyUser_Amazon.com_April_3_2016c-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> Since then, new technologies like <a href="/wiki/CRISPR" title="CRISPR">CRISPR</a> and <a href="/wiki/Gene_drives" class="mw-redirect" title="Gene drives">gene drives</a> have been introduced. </p><p>While the ability to deliberately engineer pathogens has been constrained to high-end labs run by top researchers, the technology to achieve this is rapidly becoming cheaper and more widespread.<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> For example, the diminishing cost of sequencing the <a href="/wiki/Human_genome" title="Human genome">human genome</a> (from $10 million to $1,000), the accumulation of large datasets of genetic information, the discovery of <a href="/wiki/Gene_drives" class="mw-redirect" title="Gene drives">gene drives</a>, and the discovery of <a href="/wiki/CRISPR" title="CRISPR">CRISPR</a>.<sup id="cite_ref-MyUser_Futureoflife.org_April_3_2016c_5-0" class="reference"><a href="#cite_note-MyUser_Futureoflife.org_April_3_2016c-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> Biotechnology risk is therefore a credible explanation for the <a href="/wiki/Fermi_paradox" title="Fermi paradox">Fermi paradox</a>.<sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Genetically_modified_organisms_(GMO)"><span id="Genetically_modified_organisms_.28GMO.29"></span>Genetically modified organisms (GMO)</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biotechnology_risk&action=edit&section=1" title="Edit section: Genetically modified organisms (GMO)"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>There are several advantages and disadvantages of genetically modified organisms. The disadvantages include many risks, which have been classified into six classes: 1. Health risks, 2. Environmental risks, 3. Threat to biodiversity, 4. Increase in social differences, 5. Scientific concerns, 6. Potential threat to the autonomy and welfare of farmers who wish to produce non-GM products.<sup id="cite_ref-:0_7-0" class="reference"><a href="#cite_note-:0-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="1._Health_risks">1. Health risks</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biotechnology_risk&action=edit&section=2" title="Edit section: 1. Health risks"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The following are potential health risks related to the consumption of GMOs. </p> <div class="mw-heading mw-heading4"><h4 id="Unexpected_gene_interactions">Unexpected gene interactions</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biotechnology_risk&action=edit&section=3" title="Edit section: Unexpected gene interactions"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The expected outcomes of the transferred gene construct may differ due to gene interactions. It has been hypothesized that genetic modification can potentially cause changes in metabolism, though results are conflicting in animal studies.<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading4"><h4 id="Cancer_risks">Cancer risks</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biotechnology_risk&action=edit&section=4" title="Edit section: Cancer risks"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>GM crops require lower amounts of <a href="/wiki/Pesticide" title="Pesticide">pesticide</a> compared to non-GM crops.<sup id="cite_ref-Klumper2014_9-0" class="reference"><a href="#cite_note-Klumper2014-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Raman2017_10-0" class="reference"><a href="#cite_note-Raman2017-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Brookes2022_11-0" class="reference"><a href="#cite_note-Brookes2022-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> Because some pesticides' main component is <a href="/wiki/Glyphosate" title="Glyphosate">glyphosate</a>, the lower amounts of pesticides needed on GM crops may reduce the risk of <a href="/wiki/Non-Hodgkin_lymphoma" title="Non-Hodgkin lymphoma">non-Hodgkin's lymphoma</a> in workers who handle raw GM products.<sup id="cite_ref-Zhang2019_12-0" class="reference"><a href="#cite_note-Zhang2019-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Weisenburger2021_13-0" class="reference"><a href="#cite_note-Weisenburger2021-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading4"><h4 id="Allergenic_potential">Allergenic potential</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biotechnology_risk&action=edit&section=5" title="Edit section: Allergenic potential"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Allergenic potential is the potential to elicit an allergic reaction in already sensitized consumers. A particular gene that has been added to a GM crop possibly can create new allergens, and constant exposure to a particular protein allergen may have resulted in developing new allergies. This is not related directly to the use of GM technology; but since no test can predict allergenicity, it is highly possible that the new proteins or their interactions with usual proteins could produce new allergies.<sup id="cite_ref-:0_7-1" class="reference"><a href="#cite_note-:0-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading4"><h4 id="Horizontal_gene_transfer_(HGT)"><span id="Horizontal_gene_transfer_.28HGT.29"></span>Horizontal gene transfer (HGT)</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biotechnology_risk&action=edit&section=6" title="Edit section: Horizontal gene transfer (HGT)"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/wiki/Horizontal_gene_transfer" title="Horizontal gene transfer">Horizontal gene transfer</a> is any process by which an organism acquires genetic material from a second organism without descending from it. In contrast, the vertical transfer is when an organism acquires genetic material from its ancestors (i.e., its parents). HGT is the transfer of DNA between cells of the same generation. Humans and animals have been in contact with "foreign DNA". In humans, DNA has absorbed through food daily through fragments of plant and animal genes and bacterial DNA.<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Identifying_reliable_sources_(medicine)" title="Wikipedia:Identifying reliable sources (medicine)"><span title="Material near this tag needs references to reliable medical sources. (December 2022)">medical citation needed</span></a></i>]</sup> </p> <div class="mw-heading mw-heading4"><h4 id="Antibiotic_resistance">Antibiotic resistance</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biotechnology_risk&action=edit&section=7" title="Edit section: Antibiotic resistance"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Theoretically, <a href="/wiki/Antimicrobial_resistance" title="Antimicrobial resistance">antibiotic resistance</a> can occur by consuming genetically modified plants. Genes can be transferred to bacteria in the human gastrointestinal tract and develop resistance to that specific antibiotic.<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Identifying_reliable_sources_(medicine)" title="Wikipedia:Identifying reliable sources (medicine)"><span title="Material near this tag needs references to reliable medical sources. (December 2022)">medical citation needed</span></a></i>]</sup> Considering this risk factor, more research is needed.<sup id="cite_ref-:0_7-2" class="reference"><a href="#cite_note-:0-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Gain-of-function_mutations">Gain-of-function mutations</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biotechnology_risk&action=edit&section=8" title="Edit section: Gain-of-function mutations"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1236090951">.mw-parser-output .hatnote{font-style:italic}.mw-parser-output div.hatnote{padding-left:1.6em;margin-bottom:0.5em}.mw-parser-output .hatnote i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Gain-of-function_research" title="Gain-of-function research">Gain-of-function research</a></div> <div class="mw-heading mw-heading3"><h3 id="Research">Research</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biotechnology_risk&action=edit&section=9" title="Edit section: Research"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951" /><div role="note" class="hatnote navigation-not-searchable">See also: <a href="/wiki/Genetically_modified_virus" title="Genetically modified virus">Genetically modified virus</a></div> <p>Pathogens may be intentionally or unintentionally <a href="/wiki/Genetic_engineering" title="Genetic engineering">genetically modified</a> to change their characteristics, including <a href="/wiki/Virulence" title="Virulence">virulence</a> or <a href="/wiki/Toxicity" title="Toxicity">toxicity</a>.<sup id="cite_ref-GCRs_bio-chapter_2-1" class="reference"><a href="#cite_note-GCRs_bio-chapter-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> When intentional, these <a href="/wiki/Mutation" title="Mutation">mutations</a> can serve to adapt the pathogen to a laboratory setting, understand the mechanism of transmission or pathogenesis, or in the development of therapeutics. Such mutations have also been used in the development of <a href="/wiki/Biological_weapons" class="mw-redirect" title="Biological weapons">biological weapons</a>, and <a href="/wiki/Dual-use" class="mw-redirect" title="Dual-use">dual-use</a> risk continues to be a concern in the research of pathogens.<sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> The greatest concern is frequently associated with gain-of-function mutations, which confer novel or increased functionality, and the risk of their release. Gain-of-function research on viruses has been occurring since the 1970s, and came to notoriety after influenza vaccines were serially passed through animal hosts.<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (July 2021)">citation needed</span></a></i>]</sup> </p> <div class="mw-heading mw-heading4"><h4 id="Mousepox">Mousepox</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biotechnology_risk&action=edit&section=10" title="Edit section: Mousepox"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>A group of <a href="/wiki/Australians" title="Australians">Australian</a> researchers unintentionally changed characteristics of the <a href="/wiki/Mousepox" class="mw-redirect" title="Mousepox">mousepox</a> virus while trying to develop a virus to sterilize rodents as a means of <a href="/wiki/Biological_pest_control" title="Biological pest control">biological pest control</a>.<sup id="cite_ref-GCRs_bio-chapter_2-2" class="reference"><a href="#cite_note-GCRs_bio-chapter-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-mousepoxstudy_16-0" class="reference"><a href="#cite_note-mousepoxstudy-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> The modified virus became highly lethal even in <a href="/wiki/Vaccine" title="Vaccine">vaccinated</a> and naturally resistant <a href="/wiki/Mouse" title="Mouse">mice</a>.<sup id="cite_ref-Sandberg_xrisk_17-0" class="reference"><a href="#cite_note-Sandberg_xrisk-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading4"><h4 id="Influenza">Influenza</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biotechnology_risk&action=edit&section=11" title="Edit section: Influenza"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>In 2011, two laboratories published reports of mutational screens of avian <a href="/wiki/Influenza" title="Influenza">influenza</a> viruses, identifying variants which become transmissible through the air between <a href="/wiki/Ferret" title="Ferret">ferrets</a>. These viruses seem to overcome an obstacle which limits the global impact of natural <a href="/wiki/H5N1" class="mw-redirect" title="H5N1">H5N1</a>.<sup id="cite_ref-18" class="reference"><a href="#cite_note-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-MyUser_Theeuropean-magazine.com_April_3_2016c_19-0" class="reference"><a href="#cite_note-MyUser_Theeuropean-magazine.com_April_3_2016c-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> In 2012, scientists further screened point mutations of the <a href="/wiki/H5N1" class="mw-redirect" title="H5N1">H5N1</a> virus genome to identify mutations which allowed airborne spread.<sup id="cite_ref-20" class="reference"><a href="#cite_note-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-MyUser_The-scientist.com_April_3_2016c_21-0" class="reference"><a href="#cite_note-MyUser_The-scientist.com_April_3_2016c-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> While the stated goal of this research was to improve surveillance and prepare for influenza viruses which are of particular risk in causing a <a href="/wiki/Pandemic" title="Pandemic">pandemic</a>,<sup id="cite_ref-22" class="reference"><a href="#cite_note-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup> there was significant concern that the laboratory strains themselves could escape.<sup id="cite_ref-23" class="reference"><a href="#cite_note-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Marc_Lipsitch" title="Marc Lipsitch">Marc Lipsitch</a> and <a href="/wiki/Alison_P._Galvani" title="Alison P. Galvani">Alison P. Galvani</a> coauthored a paper in <a href="/wiki/PLoS_Medicine" class="mw-redirect" title="PLoS Medicine">PLoS Medicine</a> arguing that experiments in which scientists manipulate bird influenza viruses to make them transmissible in mammals deserve more intense scrutiny as to whether or not their risks outweigh their benefits.<sup id="cite_ref-24" class="reference"><a href="#cite_note-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup> Lipsitch also described influenza as the most frightening "potential pandemic pathogen".<sup id="cite_ref-25" class="reference"><a href="#cite_note-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Regulation">Regulation</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biotechnology_risk&action=edit&section=12" title="Edit section: Regulation"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>In 2014, the <a href="/wiki/United_States" title="United States">United States</a> instituted a moratorium on gain-of-function research into <a href="/wiki/Influenza" title="Influenza">influenza</a>, <a href="/wiki/MERS" title="MERS">MERS</a>, and <a href="/wiki/SARS" title="SARS">SARS</a>.<sup id="cite_ref-26" class="reference"><a href="#cite_note-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup> This was in response to the particular risks these airborne pathogens pose. However, many scientists opposed the moratorium, arguing that this limited their ability to develop <a href="/wiki/Antiviral" class="mw-redirect" title="Antiviral">antiviral</a> therapies.<sup id="cite_ref-27" class="reference"><a href="#cite_note-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup> The scientists argued gain-of-function mutations were necessary, such as adapting MERS to <a href="/wiki/Laboratory_mouse" title="Laboratory mouse">laboratory mice</a> so it could be studied. </p><p>The <a href="/wiki/National_Science_Advisory_Board_for_Biosecurity" title="National Science Advisory Board for Biosecurity">National Science Advisory Board for Biosecurity</a> also has instituted rules for research proposals using gain-of-function research of concern.<sup id="cite_ref-28" class="reference"><a href="#cite_note-28"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup> The rules outline how experiments are to be evaluated for risks, safety measures, and potential benefits; prior to funding. </p><p>In order to limit access to minimize the risk of easy access to genetic material from pathogens, including viruses, the members of the International Gene Synthesis Consortium screen orders for regulated pathogen and other dangerous sequences.<sup id="cite_ref-29" class="reference"><a href="#cite_note-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup> Orders for pathogenic or dangerous DNA are verified for customer identity, barring customers on governmental watch lists, and only to institutions "demonstrably engaged in legitimate research". </p> <div class="mw-heading mw-heading2"><h2 id="CRISPR">CRISPR</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biotechnology_risk&action=edit&section=13" title="Edit section: CRISPR"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951" /><div role="note" class="hatnote navigation-not-searchable">See also: <a href="/wiki/CRISPR" title="CRISPR">CRISPR</a></div> <p>Following surprisingly fast advances in <a href="/wiki/CRISPR" title="CRISPR">CRISPR</a> editing, an international summit proclaimed<sup class="noprint Inline-Template" style="margin-left:0.1em; white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Please_clarify" title="Wikipedia:Please clarify"><span title="The text near this tag may need clarification or removal of jargon. (May 2023)">clarification needed</span></a></i>]</sup> in December 2015 that it was "irresponsible" to proceed with human gene editing until issues in safety and efficacy were addressed.<sup id="cite_ref-MyUser_Techtimes.com_April_3_2016c_30-0" class="reference"><a href="#cite_note-MyUser_Techtimes.com_April_3_2016c-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup> One way in which CRISPR editing can cause existential risk is through <a href="/wiki/Gene_drives" class="mw-redirect" title="Gene drives">gene drives</a>, which are said to have potential to "revolutionize" <a href="/wiki/Ecosystem_management" title="Ecosystem management">ecosystem management</a>.<sup id="cite_ref-MyUser_Blogs.scientificamerican.com_April_3_2016c_31-0" class="reference"><a href="#cite_note-MyUser_Blogs.scientificamerican.com_April_3_2016c-31"><span class="cite-bracket">[</span>31<span class="cite-bracket">]</span></a></sup> Gene drives are a novel technology that have potential to make genes spread through wild populations extremely quickly. They have the potential to rapidly spread resistance genes against malaria in order to rebuff the <a href="/wiki/Malaria" title="Malaria">malaria</a> parasite <i><a href="/wiki/Plasmodium_falciparum" title="Plasmodium falciparum">Plasmodium falciparum</a></i>.<sup id="cite_ref-MyUser_Nature.com_April_3_2016c_32-0" class="reference"><a href="#cite_note-MyUser_Nature.com_April_3_2016c-32"><span class="cite-bracket">[</span>32<span class="cite-bracket">]</span></a></sup> These gene drives were originally engineered in January 2015 by Ethan Bier and Valentino Gantz; this editing was spurred by the discovery of <a href="/wiki/CRISPR-Cas9" class="mw-redirect" title="CRISPR-Cas9">CRISPR-Cas9</a>. In late 2015, <a href="/wiki/DARPA" title="DARPA">DARPA</a> started to study approaches that could halt gene drives if they went out of control and threatened biological species.<sup id="cite_ref-MyUser_Https:_April_3_2016c_33-0" class="reference"><a href="#cite_note-MyUser_Https:_April_3_2016c-33"><span class="cite-bracket">[</span>33<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biotechnology_risk&action=edit&section=14" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Global_catastrophic_risk" title="Global catastrophic risk">Global catastrophic risk</a></li> <li><a href="/wiki/Human_extinction" title="Human extinction">Human extinction</a></li> <li><a href="/wiki/Biological_warfare" title="Biological warfare">Biological warfare</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biotechnology_risk&action=edit&section=15" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-MyUser_Nickbostrom.com_April_3_2016c-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-MyUser_Nickbostrom.com_April_3_2016c_1-0">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.nickbostrom.com/existential/risks.html">"Existential Risks: Analyzing Human Extinction Scenarios"</a>. <i>Nickbostrom.com</i><span class="reference-accessdate">. Retrieved <span class="nowrap">3 April</span> 2016</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Nickbostrom.com&rft.atitle=Existential+Risks%3A+Analyzing+Human+Extinction+Scenarios&rft_id=http%3A%2F%2Fwww.nickbostrom.com%2Fexistential%2Frisks.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiotechnology+risk" class="Z3988"></span></span> </li> <li id="cite_note-GCRs_bio-chapter-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-GCRs_bio-chapter_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-GCRs_bio-chapter_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-GCRs_bio-chapter_2-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFAli_NounChristopher_F._Chyba2008" class="citation book cs1">Ali Noun; Christopher F. Chyba (2008). "Chapter 20: Biotechnology and biosecurity". 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Retrieved <span class="nowrap">3 April</span> 2016</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Stat&rft.atitle=Why+FBI+and+the+Pentagon+are+afraid+of+gene+drives&rft.date=2015-11-12&rft.aulast=Begley&rft.aufirst=Sharon&rft_id=https%3A%2F%2Fwww.statnews.com%2F2015%2F11%2F12%2Fgene-drive-bioterror-risk%2F&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiotechnology+risk" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biotechnology_risk&action=edit&section=16" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Nuclear_Threat_Initiative" title="Nuclear Threat Initiative">Nuclear Threat Initiative</a> report on <a rel="nofollow" class="external text" href="https://www.nti.org/analysis/reports/preventing-global-catastrophic-biological-risks/"><i>Preventing Global Catastrophic Biological Risks</i></a> (September 2020)</li> <li><a href="/wiki/80,000_Hours" title="80,000 Hours">80,000 Hours</a> problem profile on <i><a rel="nofollow" class="external text" href="https://80000hours.org/problem-profiles/global-catastrophic-biological-risks/">Reducing Global Catastrophic Biological Risks</a></i> (March 2020)</li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output .hlist dl ol,.mw-parser-output .hlist dl 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title="Disease burden">Disease burden</a></li> <li><a href="/wiki/Distributional_cost-effectiveness_analysis" title="Distributional cost-effectiveness analysis">Distributional cost-effectiveness analysis</a></li> <li><a href="/wiki/Earning_to_give" title="Earning to give">Earning to give</a></li> <li><a href="/wiki/Equal_consideration_of_interests" title="Equal consideration of interests">Equal consideration of interests</a></li> <li><a href="/wiki/Longtermism" title="Longtermism">Longtermism</a></li> <li><a href="/wiki/Marginal_utility" title="Marginal utility">Marginal utility</a></li> <li><a href="/wiki/Moral_circle_expansion" title="Moral circle expansion">Moral circle expansion</a></li> <li><a href="/wiki/Psychological_barriers_to_effective_altruism" title="Psychological barriers to effective altruism">Psychological barriers to effective altruism</a></li> <li><a href="/wiki/Quality-adjusted_life_year" title="Quality-adjusted life year">Quality-adjusted life year</a></li> <li><a href="/wiki/Utilitarianism" title="Utilitarianism">Utilitarianism</a></li> <li><a href="/wiki/Venture_philanthropy" title="Venture philanthropy">Venture philanthropy</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Key figures</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Sam_Bankman-Fried" title="Sam Bankman-Fried">Sam Bankman-Fried</a></li> <li><a href="/wiki/Liv_Boeree" title="Liv Boeree">Liv Boeree</a></li> <li><a href="/wiki/Nick_Bostrom" title="Nick Bostrom">Nick Bostrom</a></li> <li><a href="/wiki/Hilary_Greaves" title="Hilary Greaves">Hilary Greaves</a></li> <li><a href="/wiki/Holden_Karnofsky" title="Holden Karnofsky">Holden Karnofsky</a></li> <li><a href="/wiki/William_MacAskill" title="William MacAskill">William MacAskill</a></li> <li><a href="/wiki/Dustin_Moskovitz" title="Dustin Moskovitz">Dustin Moskovitz</a></li> <li><a href="/wiki/Yew-Kwang_Ng" title="Yew-Kwang Ng">Yew-Kwang Ng</a></li> <li><a href="/wiki/Toby_Ord" title="Toby Ord">Toby Ord</a></li> <li><a href="/wiki/Derek_Parfit" title="Derek Parfit">Derek Parfit</a></li> <li><a href="/wiki/Peter_Singer" title="Peter Singer">Peter Singer</a></li> <li><a href="/wiki/Cari_Tuna" title="Cari Tuna">Cari Tuna</a></li> <li><a href="/wiki/Eliezer_Yudkowsky" title="Eliezer Yudkowsky">Eliezer Yudkowsky</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Organizations</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/80,000_Hours" title="80,000 Hours">80,000 Hours</a></li> <li><a href="/wiki/Against_Malaria_Foundation" title="Against Malaria Foundation">Against Malaria Foundation</a></li> <li><a href="/wiki/Animal_Charity_Evaluators" title="Animal Charity Evaluators">Animal Charity Evaluators</a></li> <li><a href="/wiki/Animal_Ethics_(organization)" title="Animal Ethics (organization)">Animal Ethics</a></li> <li><a href="/wiki/Centre_for_Effective_Altruism" title="Centre for Effective Altruism">Centre for Effective Altruism</a></li> <li><a href="/wiki/Centre_for_Enabling_EA_Learning_%26_Research" title="Centre for Enabling EA Learning & Research">Centre for Enabling EA Learning & Research</a></li> <li><a href="/wiki/Center_for_High_Impact_Philanthropy" title="Center for High Impact Philanthropy">Center for High Impact Philanthropy</a></li> <li><a href="/wiki/Centre_for_the_Study_of_Existential_Risk" title="Centre for the Study of Existential Risk">Centre for the Study of Existential Risk</a></li> <li><a href="/wiki/Development_Media_International" title="Development Media International">Development Media International</a></li> <li><a href="/wiki/Evidence_Action" title="Evidence Action">Evidence Action</a></li> <li><a href="/wiki/Faunalytics" title="Faunalytics">Faunalytics</a></li> <li><a href="/wiki/Fistula_Foundation" title="Fistula Foundation">Fistula Foundation</a></li> <li><a href="/wiki/Future_of_Humanity_Institute" title="Future of Humanity Institute">Future of Humanity Institute</a></li> <li><a href="/wiki/Future_of_Life_Institute" title="Future of Life Institute">Future of Life Institute</a></li> <li><a href="/wiki/Founders_Pledge" title="Founders Pledge">Founders Pledge</a></li> <li><a href="/wiki/GiveDirectly" title="GiveDirectly">GiveDirectly</a></li> <li><a href="/wiki/GiveWell" title="GiveWell">GiveWell</a></li> <li><a href="/wiki/Giving_Multiplier" title="Giving Multiplier">Giving Multiplier</a></li> <li><a href="/wiki/Giving_What_We_Can" title="Giving What We Can">Giving What We Can</a></li> <li><a href="/wiki/Good_Food_Fund" title="Good Food Fund">Good Food Fund</a></li> <li><a href="/wiki/The_Good_Food_Institute" title="The Good Food Institute">The Good Food Institute</a></li> <li><a href="/wiki/Good_Ventures" title="Good Ventures">Good Ventures</a></li> <li><a href="/wiki/The_Humane_League" title="The Humane League">The Humane League</a></li> <li><a href="/wiki/Mercy_for_Animals" title="Mercy for Animals">Mercy for Animals</a></li> <li><a href="/wiki/Machine_Intelligence_Research_Institute" title="Machine Intelligence Research Institute">Machine Intelligence Research Institute</a></li> <li><a href="/wiki/Malaria_Consortium" title="Malaria Consortium">Malaria Consortium</a></li> <li><a href="/wiki/Open_Philanthropy_(organization)" class="mw-redirect" title="Open Philanthropy (organization)">Open Philanthropy</a></li> <li><a href="/wiki/Raising_for_Effective_Giving" title="Raising for Effective Giving">Raising for Effective Giving</a></li> <li><a href="/wiki/Sentience_Institute" title="Sentience Institute">Sentience Institute</a></li> <li><a href="/wiki/Unlimit_Health" title="Unlimit Health">Unlimit Health</a></li> <li><a href="/wiki/Wild_Animal_Initiative" title="Wild Animal Initiative">Wild Animal Initiative</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Focus areas</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a class="mw-selflink selflink">Biotechnology risk</a></li> <li><a href="/wiki/Climate_change" title="Climate change">Climate change</a></li> <li><a href="/wiki/Cultured_meat" title="Cultured meat">Cultured meat</a></li> <li><a href="/wiki/Economic_stability" title="Economic stability">Economic stability</a></li> <li><a href="/wiki/Existential_risk_from_artificial_general_intelligence" class="mw-redirect" title="Existential risk from artificial general intelligence">Existential risk from artificial general intelligence</a></li> <li><a href="/wiki/Global_catastrophic_risk" title="Global catastrophic risk">Global catastrophic risk</a></li> <li><a href="/wiki/Global_health" title="Global health">Global health</a></li> <li><a href="/wiki/Global_poverty" class="mw-redirect" title="Global poverty">Global poverty</a></li> <li><a href="/wiki/Intensive_animal_farming" title="Intensive animal farming">Intensive animal farming</a></li> <li><a href="/wiki/Land_use" title="Land use">Land use reform</a></li> <li><a href="/wiki/Life_extension" title="Life extension">Life extension</a></li> <li><a href="/wiki/Malaria_prevention" class="mw-redirect" title="Malaria prevention">Malaria prevention</a></li> <li><a href="/wiki/Mass_deworming" title="Mass deworming">Mass deworming</a></li> <li><a href="/wiki/Neglected_tropical_diseases" title="Neglected tropical diseases">Neglected tropical diseases</a></li> <li><a href="/wiki/Risk_of_astronomical_suffering" title="Risk of astronomical suffering">Risk of astronomical suffering</a></li> <li><a href="/wiki/Wild_animal_suffering" title="Wild animal suffering">Wild animal suffering</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Literature</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Doing_Good_Better" title="Doing Good Better">Doing Good Better</a></i></li> <li><i><a href="/wiki/The_End_of_Animal_Farming" title="The End of Animal Farming">The End of Animal Farming</a></i></li> <li><i><a href="/wiki/Famine,_Affluence,_and_Morality" title="Famine, Affluence, and Morality">Famine, Affluence, and Morality</a></i></li> <li><i><a href="/wiki/The_Life_You_Can_Save" title="The Life You Can Save">The Life You Can Save</a></i></li> <li><i><a href="/wiki/Living_High_and_Letting_Die" title="Living High and Letting Die">Living High and Letting Die</a></i></li> <li><i><a href="/wiki/The_Most_Good_You_Can_Do" title="The Most Good You Can Do">The Most Good You Can Do</a></i></li> <li><i><a href="/wiki/Practical_Ethics" title="Practical Ethics">Practical Ethics</a></i></li> <li><i><a href="/wiki/The_Precipice:_Existential_Risk_and_the_Future_of_Humanity" title="The Precipice: Existential Risk and the Future of Humanity">The Precipice</a></i></li> <li><i><a href="/wiki/Superintelligence:_Paths,_Dangers,_Strategies" title="Superintelligence: Paths, Dangers, Strategies">Superintelligence: Paths, Dangers, Strategies</a></i></li> <li><i><a href="/wiki/What_We_Owe_the_Future" title="What We Owe the Future">What We Owe the Future</a></i></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Events</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Effective_Altruism_Global" title="Effective Altruism Global">Effective Altruism Global</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374" /><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235" /></div><div role="navigation" class="navbox" aria-labelledby="Global_catastrophic_risks820" style="padding:3px"><table class="nowraplinks hlist mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374" /><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231" /><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Global_catastrophic_risks" title="Template:Global catastrophic risks"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Global_catastrophic_risks" title="Template talk:Global catastrophic risks"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Global_catastrophic_risks" title="Special:EditPage/Template:Global catastrophic risks"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Global_catastrophic_risks820" style="font-size:114%;margin:0 4em"><a href="/wiki/Global_catastrophic_risk" title="Global catastrophic risk">Global catastrophic risks</a></div></th></tr><tr><td class="navbox-abovebelow" colspan="2"><div> <ul><li><a href="/wiki/Future_of_Earth" title="Future of Earth">Future of the Earth</a></li> <li><a href="/wiki/Future_of_an_expanding_universe" title="Future of an expanding universe">Future of an expanding universe</a> <ul><li><a href="/wiki/Ultimate_fate_of_the_universe" title="Ultimate fate of the universe">Ultimate fate of the universe</a></li></ul></li> <li><a href="/wiki/Human_extinction#Risk_estimates" title="Human extinction">Human extinction risk estimates</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Technological</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Chemical_warfare" title="Chemical warfare">Chemical warfare</a></li> <li><a href="/wiki/Cyberattack" title="Cyberattack">Cyberattack</a> <ul><li><a href="/wiki/Cyberwarfare" title="Cyberwarfare">Cyberwarfare</a></li> <li><a href="/wiki/Cyberterrorism" title="Cyberterrorism">Cyberterrorism</a></li> <li><a href="/wiki/Cybergeddon" title="Cybergeddon">Cybergeddon</a></li> <li><a href="/wiki/Ransomware" title="Ransomware">Ransomware</a></li></ul></li> <li><a href="/wiki/Gray_goo" title="Gray goo">Gray goo</a></li> <li><a href="/wiki/Industrial_applications_of_nanotechnology#Weapons" title="Industrial applications of nanotechnology">Nanoweapons</a></li> <li><a href="/wiki/Kinetic_bombardment" title="Kinetic bombardment">Kinetic bombardment</a> <ul><li><a href="/wiki/Kinetic_energy_weapon" title="Kinetic energy weapon">Kinetic energy weapon</a></li></ul></li> <li><a href="/wiki/Nuclear_warfare" title="Nuclear warfare">Nuclear warfare</a> <ul><li><a href="/wiki/Mutual_assured_destruction" title="Mutual assured destruction">Mutual assured destruction</a></li> <li><a href="/wiki/Dead_Hand" title="Dead Hand">Dead Hand</a></li> <li><a href="/wiki/Doomsday_Clock" title="Doomsday Clock">Doomsday Clock</a></li> <li><a href="/wiki/Doomsday_device" title="Doomsday device">Doomsday device</a></li> <li><a href="/wiki/Antimatter_weapon" title="Antimatter weapon">Antimatter weapon</a></li></ul></li> <li><a href="/wiki/Electromagnetic_pulse" title="Electromagnetic pulse">Electromagnetic pulse</a> (EMP)</li> <li><a href="/wiki/Safety_of_high-energy_particle_collision_experiments" title="Safety of high-energy particle collision experiments">Safety of high-energy particle collision experiments</a> <ul><li><a href="/wiki/Micro_black_hole" title="Micro black hole">Micro black hole</a></li> <li><a href="/wiki/Strangelet" title="Strangelet">Strangelet</a></li></ul></li> <li><a href="/wiki/Synthetic_intelligence" title="Synthetic intelligence">Synthetic intelligence</a> / <a href="/wiki/Artificial_intelligence" title="Artificial intelligence">Artificial intelligence</a> <ul><li><a href="/wiki/AI_takeover" title="AI takeover">AI takeover</a></li> <li><a href="/wiki/Existential_risk_from_artificial_general_intelligence" class="mw-redirect" title="Existential risk from artificial general intelligence">Existential risk from artificial intelligence</a></li> <li><a href="/wiki/Technological_singularity" title="Technological singularity">Technological singularity</a></li></ul></li> <li><a href="/wiki/Transhumanism" title="Transhumanism">Transhumanism</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Sociological</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Anthropogenic_hazard" class="mw-redirect" title="Anthropogenic hazard">Anthropogenic hazard</a></li> <li><a href="/wiki/Collapsology" title="Collapsology">Collapsology</a></li> <li><a href="/wiki/Doomsday_argument" title="Doomsday argument">Doomsday argument</a> <ul><li><a href="/wiki/Self-indication_assumption_doomsday_argument_rebuttal" title="Self-indication assumption doomsday argument rebuttal">Self-indication assumption doomsday argument rebuttal</a></li> <li><a href="/wiki/Self-referencing_doomsday_argument_rebuttal" title="Self-referencing doomsday argument rebuttal">Self-referencing doomsday argument rebuttal</a></li></ul></li> <li><a href="/wiki/Economic_collapse" title="Economic collapse">Economic collapse</a></li> <li><a href="/wiki/Malthusianism" title="Malthusianism">Malthusian catastrophe</a></li> <li><a href="/wiki/New_World_Order_(conspiracy_theory)" class="mw-redirect" title="New World Order (conspiracy theory)">New World Order (conspiracy theory)</a></li> <li><a href="/wiki/Nuclear_holocaust" title="Nuclear holocaust">Nuclear holocaust</a> <ul><li><a href="/wiki/Cobalt_bomb" title="Cobalt bomb">cobalt</a></li> <li><a href="/wiki/Nuclear_famine" title="Nuclear famine">famine</a></li> <li><a href="/wiki/Nuclear_winter" title="Nuclear winter">winter</a></li></ul></li> <li><a href="/wiki/Riot" title="Riot">Riots</a></li> <li><a href="/wiki/Social_crisis" title="Social crisis">Social crisis</a></li> <li><a href="/wiki/Societal_collapse" title="Societal collapse">Societal collapse</a></li> <li><a href="/wiki/State_collapse" title="State collapse">State collapse</a></li> <li><a href="/wiki/World_War_III" title="World War III">World War III</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Climate_apocalypse" title="Climate apocalypse">Ecological</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Climate_variability_and_change" title="Climate variability and change">Climate change</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Anoxic_event" title="Anoxic event">Anoxic event</a></li> <li><a href="/wiki/Biodiversity_loss" title="Biodiversity loss">Biodiversity loss</a> <ul><li><a href="/wiki/Mass_mortality_event" title="Mass mortality event">Mass mortality event</a></li></ul></li> <li><a href="/wiki/Cascade_effect_(ecology)" title="Cascade effect (ecology)">Cascade effect</a></li> <li><a href="/wiki/Cataclysmic_pole_shift_hypothesis" title="Cataclysmic pole shift hypothesis">Cataclysmic pole shift hypothesis</a></li> <li><a href="/wiki/Deforestation" title="Deforestation">Deforestation</a></li> <li><a href="/wiki/Desertification" title="Desertification">Desertification</a></li> <li><a href="/wiki/Extinction_risk_from_climate_change" title="Extinction risk from climate change">Plant or animal species extinctions</a></li> <li><a href="/wiki/Climate_change_and_civilizational_collapse" title="Climate change and civilizational collapse">Civilizational collapse</a> <ul><li><a href="/wiki/Tipping_points_in_the_climate_system" title="Tipping points in the climate system">Tipping points</a></li> <li><a href="/wiki/Climate_sensitivity" title="Climate sensitivity">Climate sensitivity</a></li></ul></li> <li><a href="/wiki/Flood_basalt" title="Flood basalt">Flood basalt</a></li> <li><a href="/wiki/Global_dimming" title="Global dimming">Global dimming</a></li> <li><a href="/wiki/Global_terrestrial_stilling" title="Global terrestrial stilling">Global terrestrial stilling</a></li> <li><a href="/wiki/Climate_change" title="Climate change">Global warming</a></li> <li><a href="/wiki/Hypercane" title="Hypercane">Hypercane</a></li> <li><a href="/wiki/Ice_age" title="Ice age">Ice age</a></li> <li><a href="/wiki/Ecocide" title="Ecocide">Ecocide</a></li> <li><a href="/wiki/Ecological_collapse" class="mw-redirect" title="Ecological collapse">Ecological collapse</a></li> <li><a href="/wiki/Environmental_degradation" title="Environmental degradation">Environmental degradation</a></li> <li><a href="/wiki/Habitat_destruction" title="Habitat destruction">Habitat destruction</a></li> <li><a href="/wiki/Human_impact_on_the_environment" title="Human impact on the environment">Human impact on the environment</a> <ul><li><a href="/wiki/Environmental_issues_with_coral_reefs" title="Environmental issues with coral reefs">coral reefs</a></li> <li><a href="/wiki/Human_impact_on_marine_life" title="Human impact on marine life">on marine life</a></li></ul></li> <li><a href="/wiki/Land_degradation" title="Land degradation">Land degradation</a></li> <li><a href="/wiki/Land_consumption" title="Land consumption">Land consumption</a></li> <li><a href="/wiki/Land_surface_effects_on_climate" title="Land surface effects on climate">Land surface effects on climate</a></li> <li><a href="/wiki/Ocean_acidification" title="Ocean acidification">Ocean acidification</a></li> <li><a href="/wiki/Ozone_depletion" title="Ozone depletion">Ozone depletion</a></li> <li><a href="/wiki/Resource_depletion" title="Resource depletion">Resource depletion</a></li> <li><a href="/wiki/Sea_level_rise" title="Sea level rise">Sea level rise</a></li> <li><a href="/wiki/Supervolcano" title="Supervolcano">Supervolcano</a> <ul><li><a href="/wiki/Volcanic_winter" title="Volcanic winter">winter</a></li></ul></li> <li><a href="/wiki/Verneshot" title="Verneshot">Verneshot</a></li> <li><a href="/wiki/Water_pollution" title="Water pollution">Water pollution</a></li> <li><a href="/wiki/Water_scarcity" title="Water scarcity">Water scarcity</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Earth_Overshoot_Day" title="Earth Overshoot Day">Earth Overshoot Day</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Overexploitation" title="Overexploitation">Overexploitation</a></li> <li><a href="/wiki/Overpopulation" title="Overpopulation">Overpopulation</a> <ul><li><a href="/wiki/Human_overpopulation" title="Human overpopulation">Human overpopulation</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Biological</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Extinction" title="Extinction">Extinction</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Extinction_event" title="Extinction event">Extinction event</a></li> <li><a href="/wiki/Holocene_extinction" title="Holocene extinction">Holocene extinction</a></li> <li><a href="/wiki/Human_extinction" title="Human extinction">Human extinction</a></li> <li><a href="/wiki/List_of_extinction_events" title="List of extinction events">List of extinction events</a></li> <li><a href="/wiki/Genetic_erosion" title="Genetic erosion">Genetic erosion</a></li> <li><a href="/wiki/Genetic_pollution" title="Genetic pollution">Genetic pollution</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Others</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Biodiversity_loss" title="Biodiversity loss">Biodiversity loss</a> <ul><li><a href="/wiki/Decline_in_amphibian_populations" title="Decline in amphibian populations">Decline in amphibian populations</a></li> <li><a href="/wiki/Decline_in_insect_populations" title="Decline in insect populations">Decline in insect populations</a></li></ul></li> <li><a class="mw-selflink selflink">Biotechnology risk</a> <ul><li><a href="/wiki/Biological_agent" title="Biological agent">Biological agent</a></li> <li><a href="/wiki/Biological_warfare" title="Biological warfare">Biological warfare</a></li> <li><a href="/wiki/Bioterrorism" title="Bioterrorism">Bioterrorism</a></li></ul></li> <li><a href="/wiki/Colony_collapse_disorder" title="Colony collapse disorder">Colony collapse disorder</a></li> <li><a href="/wiki/Defaunation" title="Defaunation">Defaunation</a></li> <li><a href="/wiki/Dysgenics" title="Dysgenics">Dysgenics</a></li> <li><a href="/wiki/Interplanetary_contamination" title="Interplanetary contamination">Interplanetary contamination</a></li> <li><a href="/wiki/Pandemic" title="Pandemic">Pandemic</a></li> <li><a href="/wiki/Pollinator_decline" title="Pollinator decline">Pollinator decline</a></li> <li><a href="/wiki/Overfishing" title="Overfishing">Overfishing</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Astronomical</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Big_Crunch" title="Big Crunch">Big Crunch</a></li> <li><a href="/wiki/Big_Rip" title="Big Rip">Big Rip</a></li> <li><a href="/wiki/Coronal_mass_ejection" title="Coronal mass ejection">Coronal mass ejection</a></li> <li><a href="/wiki/Cosmological_phase_transition" title="Cosmological phase transition">Cosmological phase transition</a></li> <li><a href="/wiki/Geomagnetic_storm" title="Geomagnetic storm">Geomagnetic storm</a></li> <li><a href="/wiki/False_vacuum_decay" class="mw-redirect" title="False vacuum decay">False vacuum decay</a></li> <li><a href="/wiki/Gamma-ray_burst" title="Gamma-ray burst">Gamma-ray burst</a></li> <li><a href="/wiki/Heat_death_of_the_universe" title="Heat death of the universe">Heat death of the universe</a></li> <li><a href="/wiki/Proton_decay" title="Proton decay">Proton decay</a></li> <li><a href="/wiki/Virtual_black_hole" title="Virtual black hole">Virtual black hole</a></li> <li><a href="/wiki/Impact_event" title="Impact event">Impact event</a> <ul><li><a href="/wiki/Asteroid_impact_avoidance" title="Asteroid impact avoidance">Asteroid impact avoidance</a></li> <li><a href="/wiki/Asteroid_impact_prediction" title="Asteroid impact prediction">Asteroid impact prediction</a></li> <li><a href="/wiki/Potentially_hazardous_object" title="Potentially hazardous object">Potentially hazardous object</a> <ul><li><a href="/wiki/Near-Earth_object" title="Near-Earth object">Near-Earth object</a></li></ul></li> <li><a href="/wiki/Impact_winter" title="Impact winter">winter</a></li> <li><a href="/wiki/Rogue_planet" title="Rogue planet">Rogue planet</a></li> <li><a href="/wiki/Intergalactic_star" title="Intergalactic star">Rogue star</a></li></ul></li> <li><a href="/wiki/Near-Earth_supernova" title="Near-Earth supernova">Near-Earth supernova</a></li> <li><a href="/wiki/Hypernova" title="Hypernova">Hypernova</a></li> <li><a href="/wiki/Micronova" title="Micronova">Micronova</a></li> <li><a href="/wiki/Solar_flare" title="Solar flare">Solar flare</a></li> <li><a href="/wiki/Stellar_collision" title="Stellar collision">Stellar collision</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Eschatology" title="Eschatology">Eschatological</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Buddhist_eschatology" title="Buddhist eschatology">Buddhist</a> <ul><li><a href="/wiki/Maitreya" title="Maitreya">Maitreya</a></li> <li><a href="/wiki/Three_Ages_of_Buddhism" class="mw-redirect" title="Three Ages of Buddhism">Three Ages</a></li></ul></li> <li><a href="/wiki/Hindu_eschatology" title="Hindu eschatology">Hindu</a> <ul><li><a href="/wiki/Kalki" title="Kalki">Kalki</a></li> <li><a href="/wiki/Kali_Yuga" title="Kali Yuga">Kali Yuga</a></li></ul></li> <li><a href="/wiki/Last_Judgment" title="Last Judgment">Last Judgement</a></li> <li><a href="/wiki/Second_Coming" title="Second Coming">Second Coming</a> <ul><li><a href="/wiki/Book_of_Enoch" title="Book of Enoch">1 Enoch</a></li> <li><a href="/wiki/Book_of_Daniel" title="Book of Daniel">Daniel</a> <ul><li><a href="/wiki/Abomination_of_desolation" title="Abomination of desolation">Abomination of desolation</a></li> <li><a href="/wiki/Prophecy_of_Seventy_Weeks" title="Prophecy of Seventy Weeks">Prophecy of Seventy Weeks</a></li></ul></li> <li><a href="/wiki/Messiah" title="Messiah">Messiah</a></li> <li><a href="/wiki/Christian_eschatology" title="Christian eschatology">Christian</a> <ul><li><a href="/wiki/Futurism_(Christianity)" title="Futurism (Christianity)">Futurism</a></li> <li><a href="/wiki/Historicism_(Christianity)" title="Historicism (Christianity)">Historicism</a> <ul><li><a href="/wiki/Historicist_interpretations_of_the_Book_of_Revelation" title="Historicist interpretations of the Book of Revelation">Interpretations of Revelation</a></li></ul></li> <li><a href="/wiki/Idealism_(Christian_eschatology)" title="Idealism (Christian eschatology)"> Idealism</a></li> <li><a href="/wiki/Preterism" title="Preterism">Preterism</a></li> <li><a href="/wiki/2_Esdras" title="2 Esdras">2 Esdras</a></li> <li><a href="/wiki/Second_Epistle_to_the_Thessalonians" title="Second Epistle to the Thessalonians">2 Thessalonians</a> <ul><li><a href="/wiki/Man_of_sin" title="Man of sin">Man of sin</a></li> <li><a href="/wiki/Katechon" title="Katechon">Katechon</a></li></ul></li> <li><a href="/wiki/Antichrist" title="Antichrist">Antichrist</a></li> <li><a href="/wiki/Book_of_Revelation" title="Book of Revelation">Book of Revelation</a> <ul><li><a href="/wiki/Events_of_Revelation" title="Events of Revelation">Events</a> <ul><li><a href="/wiki/Four_Horsemen_of_the_Apocalypse" title="Four Horsemen of the Apocalypse">Four Horsemen of the Apocalypse</a></li> <li><a href="/wiki/Lake_of_fire" title="Lake of fire">Lake of fire</a></li> <li><a href="/wiki/Number_of_the_beast" title="Number of the beast">Number of the Beast</a></li> <li><a href="/wiki/Seven_bowls" title="Seven bowls">Seven bowls</a></li> <li><a href="/wiki/Seven_seals" title="Seven seals">Seven seals</a></li> <li><a href="/wiki/The_Beast_(Revelation)" title="The Beast (Revelation)">The Beast</a></li> <li><a href="/wiki/Two_witnesses" title="Two witnesses">Two witnesses</a></li> <li><a href="/wiki/War_in_Heaven" title="War in Heaven">War in Heaven</a></li> <li><a href="/wiki/Whore_of_Babylon" title="Whore of Babylon">Whore of Babylon</a></li></ul></li></ul></li> <li><a href="/wiki/Great_Apostasy" title="Great Apostasy">Great Apostasy</a></li> <li><a href="/wiki/New_Earth_(Christianity)" title="New Earth (Christianity)">New Earth</a></li> <li><a href="/wiki/New_Jerusalem" title="New Jerusalem">New Jerusalem</a></li> <li><a href="/wiki/Olivet_Discourse" title="Olivet Discourse">Olivet Discourse</a> <ul><li><a href="/wiki/Great_Tribulation" title="Great Tribulation">Great Tribulation</a></li></ul></li> <li><a href="/wiki/Son_of_perdition" title="Son of perdition">Son of perdition</a></li> <li><a href="/wiki/The_Sheep_and_the_Goats" title="The Sheep and the Goats">Sheep and Goats</a></li></ul></li> <li><a href="/wiki/Islamic_eschatology" title="Islamic eschatology">Islamic</a> <ul><li><a href="/wiki/Qa%27im_Al_Muhammad" title="Qa'im Al Muhammad">Al-Qa'im</a></li> <li><a href="/wiki/Beast_of_the_Earth" title="Beast of the Earth">Beast of the Earth</a></li> <li><a href="/wiki/Dhu_al-Qarnayn" title="Dhu al-Qarnayn">Dhu al-Qarnayn</a></li> <li><a href="/wiki/Dhul-Suwayqatayn" title="Dhul-Suwayqatayn">Dhul-Suwayqatayn</a></li> <li><a href="/wiki/Al-Masih_ad-Dajjal" title="Al-Masih ad-Dajjal">Dajjal</a></li> <li><a href="/wiki/Israfil" title="Israfil">Israfil</a></li> <li><a href="/wiki/Mahdi" title="Mahdi">Mahdi</a></li> <li><a href="/wiki/Sufyani" title="Sufyani">Sufyani</a></li></ul></li> <li><a href="/wiki/Jewish_eschatology" title="Jewish eschatology">Jewish</a> <ul><li><a href="/wiki/Messiah_in_Judaism" title="Messiah in Judaism">Messiah</a></li> <li><a href="/wiki/Gog_and_Magog" title="Gog and Magog">War of Gog and Magog</a></li> <li><a href="/wiki/Third_Temple" title="Third Temple">Third Temple</a></li></ul></li></ul></li> <li><a href="/wiki/Ragnar%C3%B6k" title="Ragnarök">Norse</a></li> <li><a href="/wiki/Frashokereti" title="Frashokereti">Zoroastrian</a> <ul><li><a href="/wiki/Saoshyant" title="Saoshyant">Saoshyant</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Others</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/2011_end_times_prediction" title="2011 end times prediction">2011 end times prediction</a></li> <li><a href="/wiki/2012_phenomenon" title="2012 phenomenon">2012 phenomenon</a></li> <li><a href="/wiki/Apocalypse" title="Apocalypse">Apocalypse</a></li> <li><a href="/wiki/Apocalyptic_literature" title="Apocalyptic literature">Apocalyptic literature</a></li> <li><a href="/wiki/Apocalypticism" title="Apocalypticism">Apocalypticism</a></li> <li><a href="/wiki/Armageddon" title="Armageddon">Armageddon</a></li> <li><a href="/wiki/Blood_moon_prophecy" title="Blood moon prophecy">Blood moon prophecy</a></li> <li><a href="/wiki/Earth_Changes" title="Earth Changes">Earth Changes</a></li> <li><a href="/wiki/Global_catastrophic_risk" title="Global catastrophic risk">End time</a></li> <li><a href="/wiki/Gog_and_Magog" title="Gog and Magog">Gog and Magog</a></li> <li><a href="/wiki/List_of_dates_predicted_for_apocalyptic_events" title="List of dates predicted for apocalyptic events">List of dates predicted for apocalyptic events</a></li> <li><a href="/wiki/Messianism" title="Messianism">Messianism</a> <ul><li><a href="/wiki/Messianic_Age" title="Messianic Age">Messianic Age</a></li></ul></li> <li><a href="/wiki/Millenarianism" title="Millenarianism">Millenarianism</a></li> <li><a href="/wiki/Millennialism" title="Millennialism">Millennialism</a> <ul><li><a href="/wiki/Premillennialism" title="Premillennialism">Premillennialism</a></li> <li><a href="/wiki/Amillennialism" title="Amillennialism">Amillennialism</a></li> <li><a href="/wiki/Postmillennialism" title="Postmillennialism">Postmillennialism</a></li></ul></li> <li><a href="/wiki/Nemesis_(hypothetical_star)" title="Nemesis (hypothetical star)">Nemesis (hypothetical star)</a></li> <li><a href="/wiki/Nibiru_cataclysm" title="Nibiru cataclysm">Nibiru cataclysm</a></li> <li><a href="/wiki/Rapture" title="Rapture">Rapture</a> <ul><li><a href="/wiki/Rapture#Prewrath_premillennialism" title="Rapture">Prewrath</a></li> <li><a href="/wiki/Posttribulation_rapture" title="Posttribulation rapture">Posttribulation rapture</a></li></ul></li> <li><a href="/wiki/Universal_resurrection" title="Universal resurrection">Resurrection of the dead</a></li> <li><a href="/wiki/Vulnerable_world_hypothesis" title="Vulnerable world hypothesis">Vulnerable world hypothesis</a></li> <li><a href="/wiki/World_to_come" title="World to come">World to come</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Fictional</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Alien_invasion" title="Alien invasion">Alien invasion</a></li> <li><a href="/wiki/Apocalyptic_and_post-apocalyptic_fiction" title="Apocalyptic and post-apocalyptic fiction">Apocalyptic and post-apocalyptic fiction</a> <ul><li><a href="/wiki/List_of_apocalyptic_and_post-apocalyptic_fiction" title="List of apocalyptic and post-apocalyptic fiction">List of apocalyptic and post-apocalyptic fiction</a></li> <li><a href="/wiki/List_of_apocalyptic_films" title="List of apocalyptic films">List of apocalyptic films</a></li></ul></li> <li><a href="/wiki/Climate_fiction" title="Climate fiction">Climate fiction</a></li> <li><a href="/wiki/Disaster_film" title="Disaster film">Disaster films</a> <ul><li><a href="/wiki/List_of_disaster_films" title="List of disaster films">List of disaster films</a></li></ul></li> <li><a href="/wiki/Zombie_apocalypse" title="Zombie apocalypse">Zombie apocalypse</a> <ul><li><a href="/wiki/Zombie" title="Zombie">Zombie</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Organizations</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Centre_for_the_Study_of_Existential_Risk" title="Centre for the Study of Existential Risk">Centre for the Study of Existential Risk</a></li> <li><a href="/wiki/Future_of_Humanity_Institute" title="Future of Humanity Institute">Future of Humanity Institute</a></li> <li><a href="/wiki/Future_of_Life_Institute" title="Future of Life Institute">Future of Life Institute</a></li> <li><a href="/wiki/Nuclear_Threat_Initiative" title="Nuclear Threat Initiative">Nuclear Threat Initiative</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">General</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Disaster" title="Disaster">Disaster</a></li> <li><a href="/wiki/Economic_depression" title="Economic depression">Depression</a></li> <li><a href="/wiki/Financial_crisis" title="Financial crisis">Financial crisis</a></li> <li><a href="/wiki/Survivalism" title="Survivalism">Survivalism</a></li></ul> </div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div> <ul><li><b><span class="nowrap"><span class="noviewer" typeof="mw:File"><a href="/wiki/File:The_Earth_seen_from_Apollo_17.jpg" class="mw-file-description"><img alt="" src="//upload.wikimedia.org/wikipedia/commons/thumb/9/97/The_Earth_seen_from_Apollo_17.jpg/15px-The_Earth_seen_from_Apollo_17.jpg" decoding="async" width="15" height="15" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/97/The_Earth_seen_from_Apollo_17.jpg/23px-The_Earth_seen_from_Apollo_17.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/97/The_Earth_seen_from_Apollo_17.jpg/30px-The_Earth_seen_from_Apollo_17.jpg 2x" data-file-width="3000" data-file-height="3002" /></a></span> </span><a href="/wiki/Portal:World" title="Portal:World">World portal</a></b></li> <li><span class="noviewer" typeof="mw:File"><span title="Category"><img alt="" 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