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This study aimed to analyze the prevalence of CLABSI and the effectiveness of antimicrobial lock therapy (ALT) in pediatric patients." /> <meta name="twitter:image" content="http://a.academia-assets.com/images/twitter-card.jpeg" /> <meta property="fb:app_id" content="2369844204" /> <meta property="og:type" content="article" /> <meta property="og:url" content="https://www.academia.edu/14115144/Central_venous_catheter_associated_bloodstream_infections_in_pediatric_hematology_oncology_patients_and_effectiveness_of_antimicrobial_lock_therapy" /> <meta property="og:title" content="Central venous catheter-associated bloodstream infections in pediatric hematology-oncology patients and effectiveness of antimicrobial lock therapy" /> <meta property="og:image" content="http://a.academia-assets.com/images/open-graph-icons/fb-paper.gif" /> <meta property="og:description" content="Central line-associated bloodstream infection (CLABSI) is a serious complication in hematology-oncology patients. This study aimed to analyze the prevalence of CLABSI and the effectiveness of antimicrobial lock therapy (ALT) in pediatric patients." /> <meta property="article:author" content="https://taiwan.academia.edu/LuanyinChang" /> <meta property="article:author" content="https://independent.academia.edu/LuChunyi" /> <meta name="description" content="Central line-associated bloodstream infection (CLABSI) is a serious complication in hematology-oncology patients. This study aimed to analyze the prevalence of CLABSI and the effectiveness of antimicrobial lock therapy (ALT) in pediatric patients." /> <title>(PDF) Central venous catheter-associated bloodstream infections in pediatric hematology-oncology patients and effectiveness of antimicrobial lock therapy | Luan-yin Chang and Chun-yi Lu - Academia.edu</title> <link rel="canonical" href="https://www.academia.edu/14115144/Central_venous_catheter_associated_bloodstream_infections_in_pediatric_hematology_oncology_patients_and_effectiveness_of_antimicrobial_lock_therapy" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = '49879c2402910372f4abc62630a427bbe033d190'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1732466056000); window.Aedu.timeDifference = new Date().getTime() - 1732466056000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":"Central line-associated bloodstream infection (CLABSI) is a serious complication in hematology-oncology patients. This study aimed to analyze the prevalence of CLABSI and the effectiveness of antimicrobial lock therapy (ALT) in pediatric patients. BSIs of all pediatric hematology-oncology patients admitted to a children\u0026amp;amp;#39;s hospital between January 2009 and December 2013 were reviewed. The United States National Healthcare Safety Network and Infectious Diseases Society of America guidelines were used to define CLABSI and catheter-related BSI (CRBSI). The incidence, laboratory and microbiology characteristics, poor outcome, and effectiveness of ALT were analyzed. There were 246 cases of CLABSI in 146 patients (mean age, 10.0 years), including 66 (26.8%) cases of CRBSI. The incidence of CLABSI was 4.49/1000 catheter-days, and the infection was responsible for 32.9% of the complications these patients developed and 9.3% of contributable mortality. Patients with acute myeloid leukemia...","author":[{"@context":"https://schema.org","@type":"Person","name":"Luan-yin Chang"},{"@context":"https://schema.org","@type":"Person","name":"Chun-yi Lu"}],"contributor":[{"@context":"https://schema.org","@type":"Person","name":"Chun-yi Lu"}],"dateCreated":"2015-07-16","dateModified":"2023-12-21","datePublished":"2014-01-10","headline":"Central venous catheter-associated bloodstream infections in pediatric hematology-oncology patients and effectiveness of antimicrobial lock therapy","inLanguage":"en","keywords":["Microbiology","Nursing","Immunology","Statistical Analysis","Medical Microbiology","Risk assessment","Adolescent","Home Care","Multivariate Analysis","Humans","Child","Infection Control","Female","Blood","Male","Bacteria","Cohort Study","Young Adult","Infant","Data Collection","Skin","Incidence","Risk factors","Newborn Infant","Intensive Care Unit","Aged","Middle Aged","Anti-Bacterial Agents","Adult","Sex Factors","Enterococcus","Retrospective Studies","Bacterial growth","Pyridines","Staphylococcus","Bacteremia","Corynebacterium","Risk Factors","Risk Assessment","Hematologic Diseases","Central Venous Catheter","Logistic Regression Model","Cross-infection","Proportional Hazards Models"],"locationCreated":null,"publication":"Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi","publisher":{"@context":"https://schema.org","@type":"Organization","name":null},"image":null,"thumbnailUrl":null,"url":"https://www.academia.edu/14115144/Central_venous_catheter_associated_bloodstream_infections_in_pediatric_hematology_oncology_patients_and_effectiveness_of_antimicrobial_lock_therapy","sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":"taiwan"},{"@context":"https://schema.org","@type":"EducationalOrganization","name":null}]}</script><link rel="stylesheet" media="all" 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{"work":{"id":14115144,"created_at":"2015-07-16T07:34:04.966-07:00","from_world_paper_id":139609150,"updated_at":"2021-01-16T04:49:42.830-08:00","_data":{"abstract":"Central line-associated bloodstream infection (CLABSI) is a serious complication in hematology-oncology patients. This study aimed to analyze the prevalence of CLABSI and the effectiveness of antimicrobial lock therapy (ALT) in pediatric patients. BSIs of all pediatric hematology-oncology patients admitted to a children\u0026#39;s hospital between January 2009 and December 2013 were reviewed. The United States National Healthcare Safety Network and Infectious Diseases Society of America guidelines were used to define CLABSI and catheter-related BSI (CRBSI). The incidence, laboratory and microbiology characteristics, poor outcome, and effectiveness of ALT were analyzed. There were 246 cases of CLABSI in 146 patients (mean age, 10.0 years), including 66 (26.8%) cases of CRBSI. The incidence of CLABSI was 4.49/1000 catheter-days, and the infection was responsible for 32.9% of the complications these patients developed and 9.3% of contributable mortality. Patients with acute myeloid leukemia...","publication_date":"2014,1,10","publication_name":"Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Central venous catheter-associated bloodstream infections in pediatric hematology-oncology patients and effectiveness of antimicrobial lock therapy","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [33115704,43181325]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":44588983,"attachmentType":"pdf"}"><img alt="First page of “Central venous catheter-associated bloodstream infections in pediatric hematology-oncology patients and effectiveness of antimicrobial lock therapy”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/44588983/mini_magick20190214-16634-1kmd8mx.png?1550149880" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/assets/single_work_splash/adobe.icon-574afd46eb6b03a77a153a647fb47e30546f9215c0ee6a25df597a779717f9ef.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Central venous catheter-associated bloodstream infections in pediatric hematology-oncology patients and effectiveness of antimicrobial lock therapy</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="33115704" href="https://taiwan.academia.edu/LuanyinChang"><img alt="Profile image of Luan-yin Chang" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />Luan-yin Chang</a><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="43181325" href="https://independent.academia.edu/LuChunyi"><img alt="Profile image of Chun-yi Lu" class="ds-work-card--author-avatar" src="https://gravatar.com/avatar/1c93bea46af84e24be4b7f50a404083a?s=65" />Chun-yi Lu</a></div><p class="ds-work-card--detail ds2-5-body-sm">2014, Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi</p><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">Central line-associated bloodstream infection (CLABSI) is a serious complication in hematology-oncology patients. This study aimed to analyze the prevalence of CLABSI and the effectiveness of antimicrobial lock therapy (ALT) in pediatric patients. BSIs of all pediatric hematology-oncology patients admitted to a children&#39;s hospital between January 2009 and December 2013 were reviewed. The United States National Healthcare Safety Network and Infectious Diseases Society of America guidelines were used to define CLABSI and catheter-related BSI (CRBSI). The incidence, laboratory and microbiology characteristics, poor outcome, and effectiveness of ALT were analyzed. There were 246 cases of CLABSI in 146 patients (mean age, 10.0 years), including 66 (26.8%) cases of CRBSI. The incidence of CLABSI was 4.49/1000 catheter-days, and the infection was responsible for 32.9% of the complications these patients developed and 9.3% of contributable mortality. Patients with acute myeloid leukemia...</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":44588983,"attachmentType":"pdf","workUrl":"https://www.academia.edu/14115144/Central_venous_catheter_associated_bloodstream_infections_in_pediatric_hematology_oncology_patients_and_effectiveness_of_antimicrobial_lock_therapy"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":44588983,"attachmentType":"pdf","workUrl":"https://www.academia.edu/14115144/Central_venous_catheter_associated_bloodstream_infections_in_pediatric_hematology_oncology_patients_and_effectiveness_of_antimicrobial_lock_therapy"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div></div><div 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data-author-id="273781853" href="https://independent.academia.edu/cindysalgado10">cindy salgado</a></div><p class="ds-related-work--metadata ds2-5-body-xs">American Journal of Infection Control, 2013</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Reduction of Central Line Associated Bloodstream Infection in a Pediatric Hematology/Oncology Population","attachmentId":111797036,"attachmentType":"pdf","work_url":"https://www.academia.edu/115370523/Reduction_of_Central_Line_Associated_Bloodstream_Infection_in_a_Pediatric_Hematology_Oncology_Population","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/115370523/Reduction_of_Central_Line_Associated_Bloodstream_Infection_in_a_Pediatric_Hematology_Oncology_Population"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="73154646" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/73154646/Multidrug_Resistant_Bacteria_colonization_as_a_risk_factor_for_catheter_related_Infections_in_children_with_cancer">Multidrug-Resistant Bacteria colonization as a risk factor for catheter-related Infections in children with cancer</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="77603278" href="https://independent.academia.edu/TPardini">Thales Pardini</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2020</p><p class="ds-related-work--abstract ds2-5-body-sm">BACKGROUND OBJECTIVES. The aim of the current study is to analyse which factors are associated to Central-Line associated Bloodstream Infection in children during cancer treatment. METHODS. A prospective study was conducted with children admitted to the university hospital of the Federal University of Minas Gerais. All children and adolescents, up to 18 years of age, with cancer and with a central venous catheter placed were included and followed from March to December 2017. A multivariate logistic regression was performed to check if sex, age, neutrophils and platelet count, hemoglobin levels, type of neoplasia (hematologic versus solid), local of care, recent use of antibiotic and duration of catheter are predictors of Central Line-Associated Bloodstream Infection, according to Center for Disease Control and Prevention criteria. RESULTS. In the 100 eligible patients (36% girl; median age 8 years), the incidence of infection was 6.01 cases in 1000 catheter-days. The most common is...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Multidrug-Resistant Bacteria colonization as a risk factor for catheter-related Infections in children with cancer","attachmentId":81785082,"attachmentType":"pdf","work_url":"https://www.academia.edu/73154646/Multidrug_Resistant_Bacteria_colonization_as_a_risk_factor_for_catheter_related_Infections_in_children_with_cancer","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/73154646/Multidrug_Resistant_Bacteria_colonization_as_a_risk_factor_for_catheter_related_Infections_in_children_with_cancer"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="124948400" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/124948400/Risk_Factors_for_Central_Venous_Catheter_Associated_Bloodstream_Infection_in_Pediatric_Patients_A_Cohort_Study">Risk Factors for Central Venous Catheter–Associated Bloodstream Infection in Pediatric Patients: A Cohort Study</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="112122596" href="https://independent.academia.edu/HaominLi3">Haomin Li</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Infection Control &amp; Hospital Epidemiology, 2016</p><p class="ds-related-work--abstract ds2-5-body-sm">OBJECTIVETo examine the incidence of central-line–associated bloodstream infection (CLABSI) over time and to determine risk factors for CLABSI in hospitalized children.DESIGNProspective cohort study.SETTINGPediatric tertiary care referral center in Halifax, Nova Scotia, serving a population of 2.3 million.PARTICIPANTSPatients ages 0–18 years with central venous catheters (CVCs) inserted at this facility between 1995 and 2013.METHODSParticipants were followed from CVC insertion to CLABSI event or until CVC removal. Data were prospectively collected by clinicians, infection prevention and control staff, and nursing staff for the purposes of patient care, surveillance, and quality improvement. Cox proportional hazards regression was used to identify risk factors for CLABSI.RESULTSAmong 5,648 patients, 385 developed CLABSI (0.74 CLABSI per 1,000 line days; or 3.87 per 1,000 in-hospital line days). Most infections occurred within 60 days of insertion. CLABSI rates decreased from 4.87 per...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Risk Factors for Central Venous Catheter–Associated Bloodstream Infection in Pediatric Patients: A Cohort Study","attachmentId":119079283,"attachmentType":"pdf","work_url":"https://www.academia.edu/124948400/Risk_Factors_for_Central_Venous_Catheter_Associated_Bloodstream_Infection_in_Pediatric_Patients_A_Cohort_Study","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/124948400/Risk_Factors_for_Central_Venous_Catheter_Associated_Bloodstream_Infection_in_Pediatric_Patients_A_Cohort_Study"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="111012387" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/111012387/Risk_factors_for_recurrent_central_line_associated_bloodstream_infections_in_a_pediatric_intensive_care_unit">Risk factors for recurrent central line-associated bloodstream infections in a pediatric intensive care unit</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="192147552" href="https://independent.academia.edu/gokhanceylan">gokhan ceylan</a></div><p class="ds-related-work--metadata ds2-5-body-xs">DergiPark (Istanbul University), 2017</p><div class="ds-related-work--ctas"><button 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18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="116205938" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/116205938/Central_venous_catheter_related_infections_in_hematology_and_oncology_2020_updated_guidelines_on_diagnosis_management_and_prevention_by_the_Infectious_Diseases_Working_Party_AGIHO_of_the_German_Society_of_Hematology_and_Medical_Oncology_DGHO_">Central venous catheter–related infections in hematology and oncology: 2020 updated guidelines on diagnosis, management, and prevention by the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO)</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="50572089" href="https://independent.academia.edu/MarcusHentrich">Marcus Hentrich</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Annals of Hematology, 2020</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Central venous catheter–related infections in hematology and oncology: 2020 updated guidelines on diagnosis, management, and prevention by the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO)","attachmentId":112401114,"attachmentType":"pdf","work_url":"https://www.academia.edu/116205938/Central_venous_catheter_related_infections_in_hematology_and_oncology_2020_updated_guidelines_on_diagnosis_management_and_prevention_by_the_Infectious_Diseases_Working_Party_AGIHO_of_the_German_Society_of_Hematology_and_Medical_Oncology_DGHO_","alternativeTracking":true}"><span 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