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About OXLUMO® | OXLUMO® (lumasiran)
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Patients may or may not be on an Alnylam therapy.</p> <h1 class="text-align-center">OXLUMO works by reducing oxalate production</h1> <h3 class="text-align-center">OXLUMO is the first approved treatment for infants, children, and adults with primary hyperoxaluria type 1 (PH1).</h3> <p class="text-align-center">OXLUMO is a prescription medicine for the treatment of PH1 to lower oxalate in urine and blood in children and adults.</p> </div> </div> </div> </div> </div> </div> </section> </div> <div class="field--item"> <section class="image" > <div class="wrapper"> <div class="field field--name-field-sub-section field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--full-html-content paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-content field--type-text-long field--label-hidden field--items"> <div class="field--item"><div style="max-width:904px;height:auto;margin:auto;"> <article class="align-center media media--type-image media--view-mode-default"><div class="field--label sr-only">Image</div> <div class="field--item"> <img src="/sites/default/files/2023-02/learn-about-oxlumo-targets-2-copy-3x.png" width="2712" height="2313" alt="" loading="lazy" typeof="foaf:Image" /></div> </article></div> </div> </div> </div> </div> </div> </div> </section> </div> <div class="field--item"> <section class="moaSection" > <div class="wrapper"> <div class="field field--name-field-sub-section field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--full-html-content paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-content field--type-text-long field--label-hidden field--items"> <div class="field--item"><div class="ox-row-box"> <div class="video"><a data-fancybox="" href="https://player.vimeo.com/video/936474362h=f801a8be3b&badge=0&autopause=0&player_id=0&app_id=58479"> <article class="align-center media media--type-image media--view-mode-default"><div class="field--label sr-only">Image</div> <div class="field--item"> <img src="/sites/default/files/2024-07/vid%20thumbnail%20%281%29.png" width="752" height="566" alt="Video" loading="lazy" typeof="foaf:Image" /></div> </article></a></div> <div class="content"> <p>Watch this video and learn how OXLUMO works in the body.</p> <div class="action"><a class="btn" data-fancybox="" href="https://player.vimeo.com/video/936474362h=f801a8be3b&badge=0&autopause=0&player_id=0&app_id=58479">Watch Now</a></div> </div> </div> </div> </div> </div> </div> </div> </div> </section> </div> <div class="field--item"> <section class="callout educator" > <div class="wrapper"> <div class="field field--name-field-sub-section field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--full-html-content paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-content field--type-text-long field--label-hidden field--items"> <div class="field--item"><article class="align-center media media--type-image media--view-mode-default"><div class="field--label sr-only">Image</div> <div class="field--item"> <img src="/sites/default/files/2022-01/educator-icon.svg" alt="" loading="lazy" typeof="foaf:Image" /></div> </article><h2 class="text-align-center">CONNECT WITH AN ALNYLAM EDUCATOR</h2> <p class="text-align-center">Learn about primary hyperoxaluria type 1 (PH1) and treatment with OXLUMO® from one of our trained Alnylam Patient Education Liaisons (PELs).</p> <p class="note text-align-center">PELs are employees of Alnylam Pharmaceuticals. They are not acting as healthcare providers and are not part of your healthcare team.</p> <p class="text-align-center"><a class="btn" href="/patient-education-liaisons">Let’s Connect</a></p> </div> </div> </div> </div> </div> </div> </section> </div> <div class="field--item"> <section class="tiny_left pb-0" id="results" > <div class="wrapper"> <div class="field field--name-field-sub-section field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--full-html-content paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-content field--type-text-long field--label-hidden field--items"> <div class="field--item"><h2 class="text-align-center">How OXLUMO was tested in adults and children 6 years and older</h2> <p class="text-align-center"><strong>OXLUMO was studied in the largest clinical trial of patients with PH1 ever done. </strong>It was a 6-month study with 39 adults and children 6 years and older who were diagnosed with PH1, did not have advanced kidney disease, and were not on hemodialysis. During the study, 26 patients received treatment with OXLUMO, and 13 patients received a placebo (an injection containing no medication).</p> <p class="text-align-center"><strong>After 6 months, those initially on placebo were switched to OXLUMO,</strong> while patients who were receiving OXLUMO continued receiving OXLUMO.</p> <p class="text-align-center">Because urine is the main way oxalate is removed by the kidneys, the trial looked at the amount of oxalate in urine.</p> <h2 class="text-align-center green"> <br /> Results after 6 months:</h2> </div> </div> </div> </div> </div> </div> </section> </div> <div class="field--item"> <section class="results columns pt-32 pb-0" > <div class="wrapper"> <div class="field field--name-field-sub-section field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--full-html-content paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-content field--type-text-long field--label-hidden field--items"> <div class="field--item"><div class="table_title notch"><strong>OXLUMO lowered levels of oxalate in urine</strong></div> <div class="light_green_bg padding-40-p"> <article class="align-left media media--type-image media--view-mode-default"><div class="field--label sr-only">Image</div> <div class="field--item"> <img src="/sites/default/files/2023-01/fifty-three-percent.svg" alt="" loading="lazy" typeof="foaf:Image" /></div> </article><p style=" margin-top: 0; "><strong>After 6 months of treatment, patients on OXLUMO had on average 53% less oxalate in their urine than patients on placebo</strong></p> <ul><li><strong>Patients initially on placebo who switched to OXLUMO had similar reductions in urinary oxalate after 6 months of treatment</strong></li> </ul></div> </div> <div class="field--item"><div class="table_title notch text-align-center"><strong>Most patients treated with OXLUMO had normal or close-to-normal oxalate levels* in their urine</strong></div> <div class="light_green_bg text-center"> <div><img alt="84%" height="124" loading="lazy" src="/sites/default/files/2022-01/84-percent-icon.png" style="max-width:200px; margin:auto;display: block;" typeof="foaf:Image" /></div> <div style="margin-top:16px;text-align:center"><strong>of patients treated with OXLUMO had normal (52%) or close-to-normal (32%) oxalate levels* in their urine after 6 months of treatment vs 0% of patients on placebo</strong></div> </div> <p> </p> </div> </div> </div> </div> </div> </div> </section> </div> <div class="field--item"> <section class="tiny_left pb-0 pt-32" > <div class="wrapper"> <div class="field field--name-field-sub-section field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--full-html-content paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-content field--type-text-long field--label-hidden field--items"> <div class="field--item"><h2 class="text-align-center green">Results after 30+ months:</h2> </div> </div> </div> </div> </div> </div> </section> </div> <div class="field--item"> <section class="results columns pt-32 secLongTerms" > <div class="wrapper"> <div class="field field--name-field-sub-section field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--full-html-content paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-content field--type-text-long field--label-hidden field--items"> <div class="field--item"><div class="table_title notch"><strong>Consistent results in patients who continued receiving OXLUMO</strong></div> <div class="light_green_bg padding-40-p"> <div class="space"><strong>Patients initially on OXLUMO continued to have reduced oxalate in their urine after 36 months of treatment.</strong></div> <article class="align-left media media--type-image media--view-mode-default"><div class="field--label sr-only">Image</div> <div class="field--item"> <img src="/sites/default/files/2024-07/76percent.svg" alt="Consistent Results" loading="lazy" typeof="foaf:Image" /></div> </article><p style=" margin-top: 0; "><strong>of patients on OXLUMO had normal, or close-to-normal, oxalate levels* in their urine after 36 months.</strong></p> </div> </div> <div class="field--item"><div class="table_title notch"><strong>Results in patients initially on placebo who switched to OXLUMO</strong></div> <div class="light_green_bg padding-40-p"> <div class="space"><strong>Most patients who switched to OXLUMO after 6 months on placebo had normal or close-to-normal oxalate levels* in their urine.</strong></div> <article class="align-left media media--type-image media--view-mode-default"><div class="field--label sr-only">Image</div> <div class="field--item"> <img src="/sites/default/files/2024-07/92percent.svg" alt="Switching to OXLUMO" loading="lazy" typeof="foaf:Image" /></div> </article><p style=" margin-top: 0; "><strong>of patients who switched to OXLUMO from placebo had close-to-normal oxalate levels* in their urine after 30 months on treatment.</strong></p> </div> <p class="note asterisk" style="font-size: 16px;margin-top: 2em;">A normal level of oxalate in the urine means that oxalate levels were no longer elevated above the normal range. A close-to-normal level of oxalate in the urine means that oxalate levels were elevated but within 1.5 times the higher end of the normal range.</p> </div> </div> </div> </div> </div> </div> </section> </div> <div class="field--item"> <section class="callout white smaller pt-0 pb-32" > <div class="wrapper"> <div class="field field--name-field-sub-section field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--full-html-content paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-content field--type-text-long field--label-hidden field--items"> <div class="field--item"><p class="tiny_left text-align-center"><strong><a href="#oxlumo-safety-section">See below for safety results of this trial</a></strong></p> </div> </div> </div> </div> </div> </div> </section> </div> <div class="field--item"> <section class="columns image-text brochure_mobile pt-32" > <div class="wrapper"> <div class="field field--name-field-sub-section field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--full-html-content paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-content field--type-text-long field--label-hidden field--items"> <div class="field--item"><div class="hide_mobile text-align-center image-border"><a href="/sites/default/files/2025-03/OXLUMO-Patient-Brochure.pdf" target="_blank"><img src="/sites/default/files/2023-02/brochure cover.png" width="347" height="400" alt="OXLUMO Patient Brochure Preview" typeof="foaf:Image"></a></div> </div> <div class="field--item"><h2>How OXLUMO may be able to help</h2> <p>Talk with your doctor to find out if OXLUMO is the right choice for you. </p> <p class="brochure"><span class="hide_desktop brochure image-border"><a href="/sites/default/files/2025-03/OXLUMO-Patient-Brochure.pdf" target="_blank"><img src="/sites/default/files/2022-01/oxlumo-lumasiran-patient-brochure.jpg" width="347" height="400" alt="OXLUMO Patient Brochure Preview" typeof="foaf:Image"></a></span><strong>For more information, download the patient brochure for OXLUMO.</strong></p> <p><a class="btn download" href="/sites/default/files/2025-03/OXLUMO-Patient-Brochure.pdf" target="_blank">Download</a></p> </div> </div> </div> </div> </div> </div> </section> </div> <div class="field--item"> <section class="columns image-text" > <div class="wrapper"> <div class="field field--name-field-sub-section field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--full-html-content paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-content field--type-text-long field--label-hidden field--items"> <div class="field--item"><article class="align-center media media--type-image media--view-mode-default"><div class="field--label sr-only">Image</div> <div class="field--item"> <img src="/sites/default/files/2022-01/infant-child-icon.svg" alt="" loading="lazy" typeof="foaf:Image" /></div> </article></div> <div class="field--item"><h2>How OXLUMO was tested in infants and children younger than 6 years</h2> <p><strong>In another clinical trial, OXLUMO was studied in 18 patients (infants and children younger than 6 years old) diagnosed with PH1, who did not have advanced kidney disease, and were not on hemodialysis:</strong></p> <ul> <li>All patients in the study received treatment with OXLUMO for the initial 6 months, then continued receiving OXLUMO</li> </ul> <p>Because urine is the main way oxalate is removed by the kidneys, the trial looked at the amount of oxalate in urine.</p> </div> </div> </div> </div> </div> </div> </section> </div> <div class="field--item"> <section class="callout yellow pb-32" > <div class="wrapper"> <div class="field field--name-field-sub-section field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--full-html-content paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-content field--type-text-long field--label-hidden field--items"> <div class="field--item"><p class="darkgreen">On average, patients treated with OXLUMO had 72% less oxalate in their urine<sup>†</sup> after 6 months of treatment, and 76% less oxalate in their urine<sup>†</sup> after 30 months of treatment, compared to the start of the study.</p> </div> </div> </div> </div> </div> </div> </section> </div> <div class="field--item"> <section class="pt-0" > <div class="wrapper"> <div class="field field--name-field-sub-section field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--full-html-content paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-content field--type-text-long field--label-hidden field--items"> <div class="field--item"><p class="note dagger text-align-center">Measured by the ratio of oxalate in the urine to creatinine level.</p> </div> </div> </div> </div> </div> </div> </section> </div> <div class="field--item"> <section class="columns text-image" > <div class="wrapper"> <div class="field field--name-field-sub-section field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--full-html-content paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-content field--type-text-long field--label-hidden field--items"> <div class="field--item"><h2>OXLUMO was also tested in patients with advanced disease, including people on hemodialysis</h2> <p><strong>In an additional clinical trial, OXLUMO was studied in 21 patients of all ages (including infants younger than 1 year old) diagnosed with PH1 who had advanced kidney disease. The patients were divided into 2 groups:</strong></p> <ul> <li>Group A was made up of 6 patients who were <strong>not </strong>on hemodialysis</li> <li>Group B was made up of 15 patients who were on hemodialysis</li> </ul> <p>All patients in the study received treatment with OXLUMO for the initial 6 months, then continued receiving OXLUMO</p> <p>The trial looked at the amount of oxalate in blood, which is where it collects in patients who have advanced kidney disease.</p> </div> <div class="field--item"><article class="align-center media media--type-image media--view-mode-default"><div class="field--label sr-only">Image</div> <div class="field--item"> <img src="/sites/default/files/2023-01/images-desktop-hexagon.svg" alt="" loading="lazy" typeof="foaf:Image" /></div> </article></div> </div> </div> </div> </div> </div> </section> </div> <div class="field--item"> <section class="green-box pb-32" > <div class="wrapper"> <div class="field field--name-field-sub-section field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--full-html-content paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-content field--type-text-long field--label-hidden field--items"> <div class="field--item"><div class="box-green"> <div class="table_title notch"><strong>OXLUMO reduced blood oxalate levels in patients with advanced disease, including those on hemodialysis</strong></div> <div class="box-body d-flex"> <div class="item"> <div class="img-con"><img alt="" src="/sites/default/files/2023-02/33-graphic.svg" /></div> <div class="item-content"><strong>Patients treated with OXLUMO had on average 33% less oxalate in their blood after 6 months of treatment compared to the start of treatment</strong></div> </div> <div class="item"> <div class="img-con"><img alt="" src="/sites/default/files/2023-02/42-graphic.svg" /></div> <div class="item-content"><strong>Patients treated with OXLUMO had on average 42% less oxalate in their blood (measured before hemodialysis session) after 6 months compared to the start of treatment</strong></div> </div> </div> <div> <h2 class="text-align-center">After 24 months of treatment with OXLUMO</h2> </div> <div class="box-body d-flex"> <div class="item"> <div class="img-con"><img alt="" src="/sites/default/files/2024-07/61percent.svg" /></div> <div class="item-content"><strong>Patients in Group A had on average 61% less oxalate in their blood compared to the start of treatment</strong></div> </div> <div class="item"> <div class="img-con"><img alt="" src="/sites/default/files/2024-07/31percent.svg" /></div> <div class="item-content"><strong>Patients in Group B had on average 31% less oxalate in their blood (measured before hemodialysis session) compared to the start of treatment</strong></div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </section> </div> <div class="field--item"> <section class="callout yellow imgDisplay" > <div class="wrapper"> <div class="field field--name-field-sub-section field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--full-html-content paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-content field--type-text-long field--label-hidden field--items"> <div class="field--item"><article class="align-left media media--type-image media--view-mode-default"><div class="field--label sr-only">Image</div> <div class="field--item"> <img src="/sites/default/files/2020-08/doctor.svg" alt="" loading="lazy" typeof="foaf:Image" /></div> </article><p><strong>OXLUMO was effective in reducing levels of oxalate in urine in infants, children, and adults, as well as reducing oxalate in blood in patients with advanced kidney disease. </strong></p> </div> </div> </div> </div> </div> </div> </section> </div> <div class="field--item"> <section class="safety-profile pb-32 pt-32" id="oxlumo-safety-section" > <div class="wrapper"> <div class="field field--name-field-sub-section field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--full-html-content paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-content field--type-text-long field--label-hidden field--items"> <div class="field--item"><h2>Safety profile of OXLUMO</h2> <p>Clinical trials evaluated the safety profile of OXLUMO in 98 patients with PH1. Patients were 4 months to 61 years old at first dose.</p> <p>The most common side effect in OXLUMO clinical trials was injection site reaction. Symptoms included redness, swelling, pain, bruising, itching, and discoloration at the site of the injection. Symptoms were generally mild, resolved within one day of injection, and did not result in stopping treatment.</p> <p> </p> </div> <div class="field--item"><div class="table_title notch text-align-left fs-24 fw-extra-bold"><strong>The most common side effects in a 6-month clinical trial of 39 adults and children (age 6 and up) treated with OXLUMO were:</strong></div> <div class="light_green_bg"> <div class="dottedLine"><span><strong class="fw-extra-bold">Injection site reaction</strong></span> <ul> <li>OXLUMO: 38%</li> <li>Placebo: 0%</li> </ul> </div> <div class="dottedLine"><span><strong class="fw-extra-bold">Abdominal pain</strong></span> <ul> <li>OXLUMO: 15%</li> <li>Placebo: 8%</li> </ul> <span>Symptoms included stomach pain or discomfort</span></div> </div> </div> </div> </div> </div> <div class="field--item"> <div class="callout yellow" > <div class="field field--name-field-sub-section field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--full-html-content paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-content field--type-text-long field--label-hidden field--items"> <div class="field--item"><p class="darkgreen">After 36 months of treatment, the side effects of OXLUMO were consistent with the first 6 months of the study.</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </section> </div> <div class="field--item"> <section class="smaller pt-0 pb-0" > <div class="wrapper"> <div class="field field--name-field-sub-section field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--full-html-content paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-content field--type-text-long field--label-hidden field--items"> <div class="field--item"><p class="darkgreen"><strong>In the studies evaluating infants and children younger than 6 years (up to 30 months), and patients with advanced kidney disease including those on hemodialysis (up to 24 months), the side effects of OXLUMO seen in these studies were similar to the study above.</strong></p> <p class="darkgreen">Each patient will respond differently to treatment with OXLUMO. Talk to your doctor about any and all side effects you experience.</p> </div> </div> </div> </div> </div> </div> </section> </div> <div class="field--item"> <section class="callout yellow imgDisplay" > <div class="wrapper"> <div class="field field--name-field-sub-section field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--full-html-content paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-content field--type-text-long field--label-hidden field--items"> <div class="field--item"><article class="align-left media media--type-image media--view-mode-default"><div class="field--label sr-only">Image</div> <div class="field--item"> <img src="/sites/default/files/2020-10/doctor-icon.svg" alt="" loading="lazy" typeof="foaf:Image" /></div> </article><p><strong>For more information about the potential side effects of OXLUMO, talk to your doctor.</strong></p> <p>You can also read the <a href="https://www.alnylam.com/oxlumo-us-prescribing-information" target="_blank"><strong>Prescribing Information</strong></a>.</p> </div> </div> </div> </div> </div> </div> </section> </div> <div class="field--item"> <section class="columns support" > <div class="wrapper"> <div class="field field--name-field-sub-section field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--full-html-content paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-content field--type-text-long field--label-hidden field--items"> <div class="field--item"><article class="align-center media media--type-image media--view-mode-default"><div class="field--label sr-only">Image</div> <div class="field--item"> <img src="/sites/default/files/2022-01/dialog-icon-large.svg" alt="" loading="lazy" typeof="foaf:Image" /></div> </article><h2>We're here to help you access therapy</h2> <p>Find support services that can help you and your family during treatment with OXLUMO.</p> <p class="mobile_center"><a class="btn btn-secondary" href="/patient-support">Let’s Go</a></p> </div> <div class="field--item"><article class="align-center media media--type-image media--view-mode-default"><div class="field--label sr-only">Image</div> <div class="field--item"> <img src="/sites/default/files/2020-10/sign-up-icon.svg" alt="" loading="lazy" typeof="foaf:Image" /></div> </article><h2>Sign up for updates</h2> <p>Learn more by signing up to receive important content.</p> <p class="mobile_center"><a class="btn btn-secondary" href="/sign-up-for-updates">Sign Me Up</a></p> </div> </div> </div> </div> </div> </div> </section> </div> <div class="field--item"> <section class="callout green" > <div class="wrapper"> <div class="field field--name-field-sub-section field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--full-html-content paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-content field--type-text-long field--label-hidden field--items"> <div class="field--item"><a href="/starting-oxlumo"> <span class="inner"> <span class="left_text"> <p><em>NEXT:</em></p> <p class="hide_mobile">LEARN ABOUT OXLUMO DOSING AND HOW IT IS GIVEN</p> </span> <span class="hide_mobile align-center media"> <img src="/sites/default/files/2020-07/slash.svg" alt="" typeof="foaf:Image"> </span> <span class="right_text">STARTING<br> <span class="arrow">OXLUMO®</span> </span> </span> </a></div> </div> </div> </div> </div> </div> </section> </div> </div> <div property="schema:text" class="field--item"></div> </div> </article> </div> </div> </section> <div class="region region-content-bottom"> <div id="block-importantsafetyinformation" class="isi block block-block-content block-block-content63d76fc1-b7f0-475f-917b-98825b6fba84"> <span class="close-isi"></span> <span class="open-isi"></span> <div class="field--item"><p class="h3">IMPORTANT SAFETY INFORMATION</p> <p>The most common side effect of OXLUMO® (lumasiran) is injection site reaction (redness, swelling, pain, bruising, itching, and discoloration at the site of injection). These are not all the possible side effects of OXLUMO. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit <strong><a class="js-open-inter" href="https://www.fda.gov/medwatch" target="_blank">www.fda.gov/medwatch</a></strong>, or call <strong><a href="tel:1-800-FDA-1088">1‑800‑FDA‑1088</a></strong>.</p> <p>OXLUMO has not been studied in pregnant or breastfeeding women. 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