Human CD19 Antibody MAB4867: R&D Systems

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class="ds_title">Human CD19 Antibody </h1> <div class="dsSprite_rnd ds_brand_logo ds_rnd_logo"></div> </div> <div class="product_meta"> <span class="category_number">Catalog #: MAB4867</span> <br/> <span class="citations"> <a href="#product-citations" id="citation_count" class="jump_to" data-tab="3" data-tabname="product-citations"> 8 Citations </a> </span> <span class="reviews review_stars_4"> <a href="#product-reviews" id="product_reviews" class="jump_to" data-tab="6" data-tabname="product-reviews"> 1 Review </a> </span> <a href="/reviews/MAB4867" rel="nofollow"><span class="submit_review"><button class="btn btn-quaternary">Submit a Review</button></span></a> <span class="datasheet_link"> <a href="#product-datasheets">Datasheet / COA / SDS</a> </span> </div>  <div class="product_wrapper row"> <div class="product_ordering_wrapper col-xs-12 col-md-8 col-md-push-4"> <div class="product_ordering"> <form action="/products/human-cd19-antibody-4g7-2e3_mab4867" method="post" id="atc-datasheet-form" accept-charset="UTF-8"><div><div id="atc_datasheet_block">     <table class="add_to_cart"> <thead> <tr> <th class="ds_catalog">Catalog #</th> <th class="ds_availability_column mobile-hide">Availability</th> <th class="ds_size_price_column">Size / Price</th> <th class="ds_quantity_column">Qty</th> </tr> </thead> <tbody> <tr class="et_atc_product" data-sku="MAB4867"> <td class="dat_catalog_column">MAB4867</td> <td class="et_atc_results" colspan="2"></td> <td class="ds_quantity ds_quantity_column"><div class="form-item form-item-catnum-mab4867 form-type-textfield form-group"><input class="atc_quantity atc_hidden atc_qty form-control form-text" placeholder="0" style="display:none;" type="text" id="edit-catnum-mab4867" name="catnum-MAB4867" value="" size="5" maxlength="3" /></div></td> </tr> <tr class="et_atc_product" data-sku="MAB4867-SP"> <td class="dat_catalog_column">MAB4867-SP</td> <td class="et_atc_results" colspan="2"></td> <td class="ds_quantity ds_quantity_column"><div class="form-item form-item-catnum-mab4867-sp form-type-textfield form-group"><input class="atc_quantity atc_hidden atc_qty form-control form-text" placeholder="0" style="display:none;" type="text" id="edit-catnum-mab4867-sp" name="catnum-MAB4867-SP" value="" size="5" maxlength="3" /></div></td> </tr> </tbody> </table> <div class="ds_atc_pre_buttons"></div> <div class="ds_atc_buttons"> <a href="/quote/instruments/ella-automated-immunoassay-system" class="btn btn-secondary atc_request_quote_simple_plex_assay" style="display:none" rel="nofollow">Request a Quote</a> <a href="/services/bulk-quote-request?catnum=MAB4867&product=Human CD19 Antibody" class="btn btn-secondary atc_hidden bulk_btn" style="display:none;" rel="nofollow" title="Competitive discounts on products purchased in bulk quantities">Bulk Orders</a> <button class="btn btn-primary atc_hidden atc_btn form-submit icon-before" style="display:none;" title="Enter quantities above and click to add to cart" type="submit" id="edit-add-to-cart" name="add_to_cart_btn" value="Add to Cart"><span class="icon glyphicon glyphicon-plus" aria-hidden="true"></span> Add to Cart</button> </div> <div class="ds_atc_post_buttons"></div> </div> <input type="hidden" name="form_build_id" value="form-1zGwjYdWBNpb4yL9uhG7II_4J3va1_D3aq2LpvX0wo4" /> <input type="hidden" name="form_id" value="atc_datasheet_form" /> </div></form> </div> </div> <div class="product_image_wrapper col-xs-12 col-md-4 col-md-pull-8"> <div class="product_image"> <span class="product_image_label"> </span> <a class="ds-image overview-images" data-toggle="lightbox" data-gallery="overview-images" onClick="event.preventDefault();" data-title="Detection of CD19 in Human PBMCs by Flow Cytometry." data-footer="Detection of CD19 in Human PBMCs by Flow Cytometry." title="Cat. No. MAB4867 - Human CD19 Antibody" href="https://resources.rndsystems.com/images/datasheets/antibody/CD19_MAB4867_Flow_Cytometry_18290.jpg"> <img fetchpriority="high" src="https://resources.rndsystems.com/images/datasheets/antibody/CD19_MAB4867_Flow_Cytometry_18290.jpg" class="img-fluid" alt="Detection of CD19 in Human PBMCs by Flow Cytometry." title="Detection of CD19 in Human PBMCs by Flow Cytometry."> </a> <div class="search_image_other_count"> <span class="search_more_images">3 Images</span> </div> </div> </div> <div id="extra_images overview-images" class="hidden"> <a class="ds-image" data-toggle="lightbox" data-gallery="overview-images" data-footer="Detection of Human CD19 by Flow Cytometry" data-title="Detection of Human CD19 by Flow Cytometry" title="Cat. No. MAB4867 - Human CD19 Antibody" onClick="event.preventDefault();" href="https://resources.rndsystems.com/images/datasheets/mab4867_human-cd19-mab-clone-4g7-2e3-4120241251131.jpg"> <img src="https://resources.rndsystems.com/images/datasheets/mab4867_human-cd19-mab-clone-4g7-2e3-4120241251131.jpg" class="img-fluid" loading="lazy" alt="Detection of Human CD19 by Flow Cytometry" title="Detection of Human CD19 by Flow Cytometry"> </a> <a class="ds-image" data-toggle="lightbox" data-gallery="overview-images" data-footer="Detection of Human CD19 by Flow Cytometry" data-title="Detection of Human CD19 by Flow Cytometry" title="Cat. No. MAB4867 - Human CD19 Antibody" onClick="event.preventDefault();" href="https://resources.rndsystems.com/images/datasheets/mab4867_human-cd19-mab-clone-4g7-2e3-41202412512654.jpg"> <img src="https://resources.rndsystems.com/images/datasheets/mab4867_human-cd19-mab-clone-4g7-2e3-41202412512654.jpg" class="img-fluid" loading="lazy" alt="Detection of Human CD19 by Flow Cytometry" title="Detection of Human CD19 by Flow Cytometry"> </a> </div> </div> <div class="product_info_wrapper"> </div> <div id="view-more-target" class="datasheet_section_element"> <a href="/target/cd19?category=Primary Antibodies" class="btn btn-secondary">All CD19 Antibodies</a> </div> </div> <div class="tabbed_content" id="rnd_antibody"> <div id="ds_tabs" class="tab_menu"> <div class="tab tab_1 tab_open" data-tab="1" data-tabname="product-details" id="dsTabs_product-details"> <span>Product Details</span> </div> <div class="tab tab_3" data-tab="3" data-tabname="product-citations" id="dsTabs_product-citations"> <span>Citations (8)</span> </div> <div class="tab tab_4" data-tab="4" data-tabname="faqs" id="dsTabs_faqs"> <span>FAQs</span> </div> <div class="tab tab_5" data-tab="5" data-tabname="supplemental-products" id="dsTabs_supplemental-products"> <span>Supplemental Products</span> </div> <div class="tab tab_6" data-tab="6" data-tabname="product-reviews" id="dsTabs_product-reviews"> <span> Reviews (1) </span> </div> </div> <div class="tab_content tab_1 tab_open" data-tab="1" data-tabname="product-details" id="product-details"> <div class="datasheet_section_element"> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_summary" id="product-anchor-ds_summary">Summary</a> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_data_examples" id="product-anchor-ds_data_examples">Data Examples</a> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_preparation_storage" id="product-anchor-ds_preparation_storage">Preparation and Storage</a> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_calculator" id="product-anchor-ds_calculator">Reconstitution Calculator</a> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_background" id="product-anchor-ds_background">Background</a> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_datasheets" id="product-anchor-ds_datasheets">Product Datasheets</a> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_related_research_areas" id="product-anchor-ds_related_research_areas">Related Research Areas</a> </div> <h2 id="ds_summary">Human CD19 Antibody Summary</h2> <div class="datasheet_section"> <div class="ds_table summary_table"> <div class="ds_table_body">  <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Species Reactivity</div> <div class="ds_table_cell summary_table_data"> Human </div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Specificity</div> <div class="ds_table_cell summary_table_data"> Detects human CD19. </div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Source</div> <div class="ds_table_cell summary_table_data"> Monoclonal Mouse IgG<sub>1</sub> Clone # 4G7-2E3 </div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Purification</div> <div class="ds_table_cell summary_table_data"> Protein A or G purified from hybridoma culture supernatant </div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Immunogen</div> <div class="ds_table_cell summary_table_data"> Human CLL cells<br> </div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Formulation</div> <div class="ds_table_cell summary_table_data"> Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS. </div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Label</div> <div class="ds_table_cell summary_table_data"> Unconjugated </div> </div> </div> </div> </div> <div id="customer_also_purchased_block" class="loader" data-catalogId="MAB4867"></div> <div id="ds_applications" class="datasheet_section"> <h2>Applications</h2> <div class="ds_table app_table"> <div class="ds_table_head"> <div class="ds_table_head_row"> <div class="ds_table_head_cell app_table_blank"></div> <div class="ds_table_head_cell app_table_rec_conc">Recommended Concentration</div> <div class="ds_table_head_cell app_table_sample">Sample</div> </div> </div> <div class="ds_table_body"> <div class="ds_table_row"> <div class="ds_table_cell app_table_name">Flow Cytometry</div> <div class="ds_table_cell app_table_dilution">0.25 µg/10<sup>6</sup> cells</div> <div class="ds_table_cell app_table_sample">See below</div> </div> <div class="ds_table_row"> <div class="ds_table_cell app_table_name2">CyTOF-ready</div> <div class="ds_table_cell app_table_freeform">Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.</div> <div class="ds_table_cell app_table_sample"> </div> </div> </div> </div> <p>Please Note: Optimal dilutions should be determined by each laboratory for each application. <a href="/resources/protocols-troubleshooting-guides">General Protocols</a> are available in the Technical Information section on our website. </p> </div> <div id="ds_scientific_data" class="datasheet_section"> <div id="ds_data_examples"> <h2>Scientific Data</h2> <div id="data_examples"> <div class="row data_ex_row"> <a id="ds_image_0" class="pageAnchor"></a> <div class="data_ex_image_wrapper col-xs-12 col-sm-5 col-md-4"> <div class="data_ex_image"> <span class="data_ex_image_label"> Flow Cytometry </span> <a class="ds-image overview-images data_ex_image_link" data-toggle="lightbox" data-gallery="overview-images-0" data-title="Detection of CD19 in Human PBMCs by Flow Cytometry." data-footer="Detection of CD19 antibody in Human PBMCs antibody by Flow Cytometry." title="Cat. No. MAB4867 - Detection of CD19 antibody in Human PBMCs antibody by Flow Cytometry." href="https://resources.rndsystems.com/images/datasheets/antibody/CD19_MAB4867_Flow_Cytometry_18290.jpg"> <img loading="lazy" src="https://resources.rndsystems.com/images/datasheets/antibody/CD19_MAB4867_Flow_Cytometry_18290.jpg" class="img-fluid" alt="Detection of CD19 antibody in Human PBMCs antibody by Flow Cytometry." title="Detection of CD19 antibody in Human PBMCs antibody by Flow Cytometry."> <span class="data_ex_image_larger">View Larger</span> </a> </div> </div> <div class="data_ex_description col-xs-12 col-sm-7 col-md-8"> <p> <span class="data_ex_description_title">Detection of CD19 in Human PBMCs by Flow Cytometry.</span> Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human CD3e PE‑conjugated Monoclonal Antibody (Catalog # <a class="NoLineLink" href="https://www.rndsystems.com/products/human-cd3epsilon-pe-conjugated-antibody-ucht1_fab100p">FAB100P</a>) and either (A) Mouse Anti-Human CD19 Monoclonal Antibody (Catalog # MAB4867) or (B) Mouse IgG<SUB>1</SUB>Isotype Control (Catalog # <a class="NoLineLink" href="https://www.rndsystems.com/products/mouse-igg-1-isotype-control_mab002">MAB002</a>) followed by Allophycocyanin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # <a class="NoLineLink" href="https://www.rndsystems.com/products/mouse-f-ab-2-igg-h-l-apc-conjugated-antibody_f0101b">F0101B</a>). </p> </div> </div> <div class="row data_ex_row"> <a id="ds_image_1" class="pageAnchor"></a> <div class="data_ex_image_wrapper col-xs-12 col-sm-5 col-md-4"> <div class="data_ex_image"> <span class="data_ex_image_label"> Flow Cytometry </span> <a class="ds-image overview-images data_ex_image_link" data-toggle="lightbox" data-gallery="overview-images-1" data-title="Detection of Human CD19 by Flow Cytometry" data-footer="Detection of Human CD19 by Flow Cytometry" title="Cat. No. MAB4867 - Detection of Human CD19 by Flow Cytometry" href="https://resources.rndsystems.com/images/datasheets/mab4867_human-cd19-mab-clone-4g7-2e3-4120241251131.jpg"> <img loading="lazy" src="https://resources.rndsystems.com/images/datasheets/mab4867_human-cd19-mab-clone-4g7-2e3-4120241251131.jpg" class="img-fluid" alt="Detection of Human CD19 by Flow Cytometry" title="Detection of Human CD19 by Flow Cytometry"> <span class="data_ex_image_larger">View Larger</span> </a> </div> </div> <div class="data_ex_description col-xs-12 col-sm-7 col-md-8"> <p> <span class="data_ex_description_title">Detection of Human CD19 by Flow Cytometry</span> Common heavy-chain antibodies are specific and have neutralization potential.(a) Flow cytometry profiles obtained with different IgGs selected against CD19, EpCAM, EGFR and CD47. The profiles on antigen-negative versus -positive cell lines are shown shaded and open, respectively (for CD19: Jurkat/Raji; EpCAM: HEK-293/MCF-7; EGFR: MCF-7/A431; CD47: CHO/CHO-CD47). (b) Dose–response inhibition of SIRP alpha binding to CD47 expressed on cells for the positive control mAb B6H12 (open circles), IgGK1 (closed circles) and IgGK2 (crosses) that were directly isolated from the fixed heavy-chain libraries. (c) Neutralization potential in the SIRP alpha /CD47-binding assay for variants IgGK3 and IgGK4 (closed and open squares, respectively) obtained via optimization of IgGK2 (crosses). (d) Neutralization activity in the MSLN/MUC16 interaction assay for IgGO1 (open circles) and IgGO3 (closed triangles) in comparison with a negative control mAb (closed circles) and the therapeutic antibody Amatuximab (closed squares). (e) Dose–response binding profile measured by flow cytometry on CD19-positive Raji cells for IgG1B7 (open circles) and variants IgGL7-1 (triangles), and IgGL7-2 (closed circles) that were generated by affinity maturation. Error bars in b, c and d represent s.e.m. of two replicates. The data are representative of three independent experiments. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/25672245), licensed under a CC-BY license. Not internally tested by R&D Systems. </p> </div> </div> <div class="row data_ex_row"> <a id="ds_image_2" class="pageAnchor"></a> <div class="data_ex_image_wrapper col-xs-12 col-sm-5 col-md-4"> <div class="data_ex_image"> <span class="data_ex_image_label"> Flow Cytometry </span> <a class="ds-image overview-images data_ex_image_link" data-toggle="lightbox" data-gallery="overview-images-2" data-title="Detection of Human CD19 by Flow Cytometry" data-footer="Detection of Human CD19 by Flow Cytometry" title="Cat. No. MAB4867 - Detection of Human CD19 by Flow Cytometry" href="https://resources.rndsystems.com/images/datasheets/mab4867_human-cd19-mab-clone-4g7-2e3-41202412512654.jpg"> <img loading="lazy" src="https://resources.rndsystems.com/images/datasheets/mab4867_human-cd19-mab-clone-4g7-2e3-41202412512654.jpg" class="img-fluid" alt="Detection of Human CD19 by Flow Cytometry" title="Detection of Human CD19 by Flow Cytometry"> <span class="data_ex_image_larger">View Larger</span> </a> </div> </div> <div class="data_ex_description col-xs-12 col-sm-7 col-md-8"> <p> <span class="data_ex_description_title">Detection of Human CD19 by Flow Cytometry</span> Biological activity of bispecific kappa lambda -bodies.(a) Schematic representation of monovalent and bivalent binding of CD19xCD47 kappa lambda -bodies on the surface of CD47+/CD19−DS-1 cells (top) and CD47+/CD19+Raji cells (bottom). (b) Binding of CD47 × EpCAM (left panels) and CD47 × CD19 kappa lambda -bodies (right panels) to DS-1 (top panels) and Raji cells (bottom panels) monitored by FACS. kappa lambda bodies were used at 0.01, 0.1 and 1 mg ml−1, control staining with fluorescently labelled secondary antibody is indicated by the shaded area. (c) Inhibition of SIRP alpha binding to the CD47 on DS-1 (top) and Raji cells (bottom) by increasing concentrations of different antibodies: anti-CD47-positive control mAb B6H12 (grey open circles); CD47 × CD19 K3L7-1 (black open circles, dotted line); CD47 × CD19 K3L7-2 (closed circles); CD47 × EpCAM K3L6-1 (open triangles). Error bars represent s.e.m. of four replicates and the data are representative of three independent experiments. (d) T-cell-mediated killing of EpCAM-positive cells by CD3 × EpCAM kappa lambda -bodies. MCF-7 cells were incubated with purified human T cells in the presence of increasing concentrations of different antibodies. CD3 × EpCAM kappa lambda -bodies: L6-3L3-1 (closed circles), L6-4L3-1 (closed squares), L6-5L3-1 (closed triangles); anti-EpCAM mAbs: L6-3 (open circles), L6-4 (open squares), L6-5 (open triangles); anti-CD3 mAb L3-1 (crosses). Error bars represent s.d. of three replicates and the experiment was repeated with the blood of two independent donors. The isoelectric focusing (IEF) gels and electrophoresis profiles corresponding to the different kappa lambda -bodies and mAbs are shown in Fig. 3 and Supplementary Fig. 1. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/25672245), licensed under a CC-BY license. Not internally tested by R&D Systems. </p> </div> </div> </div> </div> </div> <div id="ds_calculator" class="datasheet_section"> <div id="btn_calculator_wrapper"><div class="datasheet_calculator_toggle btn btn-secondary" id="btn_reconstitution">Reconstitution Calculator</div></div><div id="datasheet_calculators"><div id="btn_reconstitution_calc" class="datasheet_calculator"><h2>Reconstitution Calculator</h2><div id="reconstitution_calculator" class="calculator"> <form id="recCalc"> <div class="reconstitution_calculator_text" id="reconstitution_calculator_instructions"> <p>The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.</p> </div> <div class="calc_section"> <label for="reconstitution_calculator_volume" class="calculator_label">Volume (to add to vial)</label> <input id="reconstitution_calculator_volume" name="reconstitution_calculator_volume" type="text" maxlength="16" placeholder="volume" class="calculator_input calculator_text"/> <span class="select_wrapper"> <select id="reconstitution_calculator_volume_unit" class="calculator_input calculator_select"> <option value="ml">ml</option> <option value="ul" selected="selected">ul</option> </select> </span> </div> <span class="calculator_equals calculator_operator">=</span> <div class="calc_section"> <label for="reconstitution_calculator_mass" class="calculator_label">Mass (in vial)</label> <input id="reconstitution_calculator_mass" name="reconstitution_calculator_mass" type="text" maxlength="16" placeholder="mass" class="calculator_input calculator_text"/> <span class="select_wrapper"> <select id="reconstitution_calculator_mass_unit" class="calculator_input calculator_select"> <option value="mg">mg</option> <option value="ug" selected="selected">ug</option> <option value="ng">ng</option> </select> </span> </div> <span class="calculator_divide calculator_operator">÷</span> <div class="calc_section"> <label for="reconstitution_calculator_concentration" class="calculator_label">Desired Reconstitution Concentration</label> <input id="reconstitution_calculator_concentration" name="reconstitution_calculator_concentration" type="text" maxlength="16" placeholder="conc." class="calculator_input calculator_text"/> <span class="select_wrapper"> <select id="reconstitution_calculator_concentration_unit" class="calculator_input calculator_select"> <option value="mg/ml">mg/ml</option> <option value="ug/ml" selected="selected">ug/ml</option> <option value="ng/ml">ng/ml</option> </select> </span> </div> <div id="reconstitution_foot" class="calc_section"> <input type="submit" value="Calculate" id="button_reconstitution_calculator_calculate" class="calculator_button btn btn-secondary"/> </div> </form> </div> </div></div> </div> <div id="ds_preparation_storage" class="datasheet_section"> <h2>Preparation and Storage</h2> <div class="ds_table prep_table"> <div class="ds_table_body"> <div class="ds_table_row"> <div class="ds_table_cell prep_table_name">Reconstitution</div> <div class="ds_table_cell prep_table_data">Reconstitute at 0.5 mg/mL in sterile PBS. <div id="reconstitution-buffer"> <div id="reconstitution-buffer-placeholder"> <div class="et_spinner_small"></div> Loading... </div> </div> </div> </div> <div class="ds_table_row"> <div class="ds_table_cell prep_table_name">Shipping</div> <div class="ds_table_cell prep_table_data">Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below. </div> </div> <div class="ds_table_row"> <div class="ds_table_cell prep_table_name">Stability & Storage</div> <div class="ds_table_cell prep_table_data"><b>Use a manual defrost freezer and avoid repeated freeze-thaw cycles. </b><UL><LI>12 months from date of receipt, -20 to -70 °C as supplied.</LI><LI>1 month, 2 to 8 °C under sterile conditions after reconstitution.</LI><LI>6 months, -20 to -70 °C under sterile conditions after reconstitution.</LI></UL> </div> </div> </div> </div> </div> <div id="ds_background" class="datasheet_section"> <h2>Background: CD19</h2> <p><p>CD19 is a 95 kDa transmembrane glycoprotein with two Ig-like C2-set domains. CD19 regulates B cell development and activation through interactions with CD21, CD22, and the B cell receptor. CD19 polymorphisms and up‑regulation lead to the development of autoimmunity by promoting autoantibody production. Within the extracellular domain, human CD19 (Accession # P15391) shares 57% amino acid sequence identity with mouse and rat CD19.</p></p> <div class="ds_table background_table"> <div class="ds_table_body"> <div class="ds_table_row"> <div class="ds_table_cell background_table_name">Entrez Gene IDs</div> <div class="ds_table_cell background_table_data">930 (Human); 12478 (Mouse); 365367 (Rat); 397669 (Porcine); 607898 (Canine); 102145514 (Cynomolgus Monkey); 100147468 (Equine)</div> </div> <div class="ds_table_row"> <div class="ds_table_cell background_table_name">Alternate Names</div> <div class="ds_table_cell background_table_data">B4; B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; CD19 antigen; CD19 molecule; CD19; CVID3; Differentiation antigen CD19; Leu-12; MGC12802; T-cell surface antigen Leu-12</div> </div> </div> </div> </div> <div class="datasheet_section" id="product-datasheets"> <h2 id="ds_datasheets">Product Datasheets</h2> <div class="product_datasheets"> <span class="sds-message hide"> <p class="sds-label">You must select a language.</p> <span class="close_sds_message">x</span> </span> <div class="ds_document"> <a id="cfpdf" href="//resources.rndsystems.com/pdfs/datasheets/mab4867.pdf?v=20241127" class="datasheets-link " target="_blank" rel="noreferrer nofollow">Product Datasheet</a> </div> <div class="ds_document"> <div class="ds_pdfData"><a class="datasheets-link" href="https://www.rndsystems.com/cofas/human-cd19-antibody-4g7-2e3_mab4867">COA</a> </div> </div> <div class="ds_document sds_link"> <a class="sds_non_cf datasheets-link non_cf_download_link" target="_blank" rel="noreferrer" data-path="//aero.bio-techne.com/sds/pdf/mab4867?v=20241127">SDS</a> </div> </div> </div> <div id="ds_related_research_areas" class="datasheet_section"> <h2>Related Research Areas</h2> <ul class="ds_details"> <li> <a href="/research-area/acute-lymphoblastic-leukemia">Acute Lymphoblastic Leukemia</a> </li> <li> <a href="/research-area/b-cell-activation">B Cell Activation</a> </li> <li> <a href="/research-area/b-cell-development-and-differentiation">B Cell Development and Differentiation</a> </li> <li> <a href="/research-area/b-cell-markers">B Cell Markers</a> </li> <li> <a href="/research-area/cancer-stem-cell-markers">Cancer Stem Cell Markers</a> </li> <li> <a href="/research-area/conventional-classical-dendritic-cells">Conventional/Classical Dendritic Cells</a> </li> <li> <a href="/research-area/inflammatory-monocyte--derived-dendritic-cells">Inflammatory/Monocyte-derived Dendritic Cells</a> </li> <li> <a href="/research-area/langerhans-and-dermal-dendritic-cells">Langerhans and Dermal Dendritic Cells</a> </li> <li> <a href="/research-area/lymphoid-lineage-markers">Lymphoid Lineage Markers</a> </li> <li> <a href="/research-area/multiple-myeloma">Multiple Myeloma</a> </li> <li> <a href="/research-area/natural-killer-t--nkt--cells">Natural Killer T (NKT) Cells</a> </li> <li> <a href="/research-area/plasmacytoid-dendritic-cells">Plasmacytoid Dendritic Cells</a> </li> </ul> </div> </div> <div class="tab_content tab_3" data-tab="3" data-tabname="product-citations" id="citations"> <a id="citations_section"></a> <h2><span class="citations">Citations for Human CD19 Antibody</h2> <div id="citation"> <a id="dsTabCitations"></a> <p> R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. </p> <p> <strong><span id="maxcitations">8</span> Citations: Showing <span id="showfrom">1</span> - <span id="showto">8</span> </strong> <br/><strong>Filter your results:</strong> </p> <div class="row"> <div class="col-sm-12"> <div class="citations_filters"> <p style="display:inline;"><b>Filter by:</b></p> <div class="select_wrapper filter_select"> <select id="selSpecies" title="Species"> <option value="All">All Species</option> <option class="citation_filterRadio" value="species" data-filter="Human"> Human </option> <option class="citation_filterRadio" value="species" data-filter="Rat"> Rat </option> </select> </div> <div class="select_wrapper filter_select"> <select id="selAntibody" title="Applications"> <option value="All">All Applications</option> <option class="citation_filterRadio" value="application" data-filter="Flow Cytometry"> Flow Cytometry </option> </select> </div> <div class="select_wrapper filter_select"> <select id="selSampleType" title="Sample Types"> <option value="All">All Sample Types</option> <option class="citation_filterRadio" value="sampletype" data-filter="Whole Cells"> Whole Cells </option> </select> </div> </div> </div> </div> <div class="row"> <ol id="citations" class="col-xs-12" data-expandall="false" data-max-citations="8" data-max-show="10"> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/37637934"> Increased extracellular vesicles (EVs) related to T cell-mediated inflammation and vascular function in familial hypercholesterolemia </a> </span><br/> Authors: Morten Hjuler Nielsen, Rikke Bæk, Malene Moller Jorgensen, Maiken Mellergaard, Aase Handberg<br/> Atherosclerosis Plus<br/> </li> <li class="top-lined" data-species="Rat" data-application="Flow Cytometry" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/30720108"> Fluoxetine induces direct inhibitory effects on mesenchymal stem cell?derived osteoprogenitor cells independent of serotonin concentration </a> </span><br/> Authors: SM Koura, M Salama, M El-Hussiny, MEA Khalil, A Lotfy, SA Hassan, SA Gad Elhak, MA Sobh<br/> Mol Med Rep, 2019-02-01;0(0):.<br/> Species: Rat<br/> Sample Types: Whole Cells<br/> Applications: Flow Cytometry </li> <li class="top-lined" data-species="Human" data-application="Flow Cytometry" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/28444759"> Dysregulated CD46 shedding interferes with Th1-contraction in systemic lupus erythematosus </a> </span><br/> Authors: U Ellinghaus, A Cortini, CL Pinder, GL Friec, C Kemper, TJ Vyse<br/> Eur. J. Immunol., 2017-05-22;0(0):.<br/> Species: Human<br/> Sample Types: Whole Cells<br/> Applications: Flow Cytometry </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/28153099"> Selective Blockade of the Ubiquitous Checkpoint Receptor CD47 Is Enabled by Dual-Targeting Bispecific Antibodies </a> </span><br/> Authors: Elie Dheilly, Valéry Moine, Lucile Broyer, Susana Salgado-Pires, Zoë Johnson, Anne Papaioannou et al.<br/> Molecular Therapy<br/> </li> <li class="top-lined" data-species="Human" data-application="Flow Cytometry" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/25672245"> Exploiting light chains for the scalable generation and platform purification of native human bispecific IgG. </a> </span><br/> Authors: Fischer N, Elson G, Magistrelli G, Dheilly E, Fouque N, Laurendon A, Gueneau F, Ravn U, Depoisier J, Moine V, Raimondi S, Malinge P, Di Grazia L, Rousseau F, Poitevin Y, Calloud S, Cayatte P, Alcoz M, Pontini G, Fagete S, Broyer L, Corbier M, Schrag D, Didelot G, Bosson N, Costes N, Cons L, Buatois V, Johnson Z, Ferlin W, Masternak K, Kosco-Vilbois M<br/> Nat Commun, 2015-02-12;6(0):6113.<br/> Species: Human<br/> Sample Types: Whole Cells<br/> Applications: Flow Cytometry </li> <li class="top-lined" data-species="Human" data-application="Flow Cytometry" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/25050704"> The effects of CAMPATH-1H on cell viability do not correlate to the CD52 density on the cell surface. </a> </span><br/> Authors: Lee F, Luevano M, Veys P, Yong K, Madrigal A, Shaw B, Saudemont A<br/> PLoS ONE, 2014-07-22;9(7):e103254.<br/> Species: Human<br/> Sample Types: Whole Cells<br/> Applications: Flow Cytometry </li> <li class="top-lined" data-species="Human" data-application="Flow Cytometry" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/22459945"> Role of MMPs in orchestrating inflammatory response in human monocytes via a TREM-1-PI3K-NF-kappaB pathway. </a> </span><br/> J. Cell. Sci., 2012-03-29;91(6):933-45.<br/> Species: Human<br/> Sample Types: Whole Cells<br/> Applications: Flow Cytometry </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/25862471"> Potentials and capabilities of the Extracellular Vesicle (EV) Array. </a> </span><br/> Authors: Jorgensen MM, Baek R, Varming K.<br/> J Extracell Vesicles<br/> </li> </ol> </div> </div> </div> <div class="tab_content tab_4" data-tab="4" data-tabname="product-faqs" id="product-faqs"> <h2>FAQs</h2> <div class="row"> <div class="col-xs-12"> <p>No product specific FAQs exist for this product, however you may</p> <a class="btn btn-quinary view_all_faqs_btn" href="/resources/faqs/primary-antibodies"> View all Antibody FAQs </a> </div> </div> </div> <div class="tab_content tab_5" data-tab="5" data-tabname="product-supplemental" id="supplemental-products"> <div 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value="Flow"> Flow </option> </select> </div> <div class="select_wrapper"> <select class="review_filter_species"> <option value="all">All Species</option> <option value="Mouse"> Mouse </option> </select> </div> </div> </div> </div> <br/> <div class="review_row" data-rating="4" data-species="Mouse" data-application="Flow"> <div class="row"> <div class="col-xs-12 col-sm-10"> <div class="review_title review_stars_4">Human CD19 Antibody</div> <div class="review_date">By <span class="review_reviewer">Anonymous</span> on 12/01/2017 </div> <div class="row"> <div class="review_specifics col-xs-12"> <span class="ds_review_data"> <strong>Application:</strong> Flow </span> <span class="ds_review_data"> <strong>Sample Tested: </strong> Dendritic cells </span> <span class="ds_review_data"><strong>Species:</strong> Mouse </span> </div> </div> </div> </div> <hr/> </div> </div> </div> </div> <div id="sidebar" class="col-xs-12 col-sm-4 col-md-3 col-lg-3 col-xl-3"> <div class="distributor_region"></div> 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