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Early CT Screening Significantly Improves Survival in Lung Cancer
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width="1.25rem" xmlns="http://www.w3.org/2000/svg"><polyline points="6 9 6 2 18 2 18 9"></polyline><path d="M6 18H4a2 2 0 0 1-2-2v-5a2 2 0 0 1 2-2h16a2 2 0 0 1 2 2v5a2 2 0 0 1-2 2h-2"></path><rect x="6" y="14" width="12" height="8"></rect></svg></a></button></div></div><div><div class="flex flex-wrap"><p class=" text-primary font-semibold">News</p><div class="h-[16px] border-l-2 border-gray-400 mt-1 mx-1"></div><p class=" text-primary font-semibold">Article</p><div class="h-[16px] border-l-2 border-gray-400 mt-1 mx-1 "></div><time class="text-gray-500 " dateTime="2023-11-28T13:30:00.000">November 28, 2023</time></div><h1 class="text-[26px] font-medium leading-8">Early CT Screening Significantly Improves Survival in Lung Cancer</h1><div class="py-3 text-gray-600 md:flex flex-col md:justify-between"><div class="flex flex-col xs:flex-row"><p class="mr-1 self-start">Author(s):</p><div class="flex flex-col xs:flex-row mb-3 md:mb-0"><div class="flex flex-wrap"><span class="text-md mr-2"><a class="text-author text-gray-500 hover:text-primary underline hover:no-underline decoration-gray-400" href="/authors/rina-lokaj">Rina Lokaj</a></span></div></div></div><div class="max-w-full"><div class="flex flex-wrap sm:flex-nowrap items-center w-fit my-2"></div><div class="w-full flex flex-col sm:flex-row justify-between mt-2"><div class="block md:hidden "><div class="mt-2 flex items-center max-w-fit"><button title="Early CT Screening Significantly Improves Survival in Lung Cancer" aria-label="facebook" class="react-share__ShareButton" style="background-color:transparent;border:none;padding:0;font:inherit;color:inherit;cursor:pointer"><svg viewBox="0 0 64 64" width="32" height="32"><circle cx="32" cy="32" r="31" fill="#3b5998"></circle><path d="M34.1,47V33.3h4.6l0.7-5.3h-5.3v-3.4c0-1.5,0.4-2.6,2.6-2.6l2.8,0v-4.8c-0.5-0.1-2.2-0.2-4.1-0.2 c-4.1,0-6.9,2.5-6.9,7V28H24v5.3h4.6V47H34.1z" fill="white"></path></svg></button><button aria-label="twitter" class="react-share__ShareButton" 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M20,39V26.6l12,9.3l12-9.3V39H20z" fill="white"></path></svg></button><a class="print-wrap flex justify-center items-center cursor-pointer"><svg id="print" xmlns="http://www.w3.org/2000/svg" width="24" height="24" fill="currentColor" class="print bi bi-printer" viewBox="0 0 16 16"> <path d="M2.5 8a.5.5 0 1 0 0-1 .5.5 0 0 0 0 1z"></path> <path d="M5 1a2 2 0 0 0-2 2v2H2a2 2 0 0 0-2 2v3a2 2 0 0 0 2 2h1v1a2 2 0 0 0 2 2h6a2 2 0 0 0 2-2v-1h1a2 2 0 0 0 2-2V7a2 2 0 0 0-2-2h-1V3a2 2 0 0 0-2-2H5zM4 3a1 1 0 0 1 1-1h6a1 1 0 0 1 1 1v2H4V3zm1 5a2 2 0 0 0-2 2v1H2a1 1 0 0 1-1-1V7a1 1 0 0 1 1-1h12a1 1 0 0 1 1 1v3a1 1 0 0 1-1 1h-1v-1a2 2 0 0 0-2-2H5zm7 2v3a1 1 0 0 1-1 1H5a1 1 0 0 1-1-1v-3a1 1 0 0 1 1-1h6a1 1 0 0 1 1 1z"></path></svg></a></div><style> .print-wrap { width: 32px; height: 32px; background: #7F7F7F; border-radius: 100%; } .print { background: #7F7F7F; color: white; padding: 2px; border-radius: 100%; } </style></div></div></div></div><div class=" lg:w-full flex flex-col lg:flex-row lg:items-center lg:justify-end"></div><p class="py-2 mb-2 text-sm italic text-gray-600">Early CT screening leads to a 20-year lung cancer survival rate of 81%. </p><div class="py-2"><div class="blockText_blockContent__TbCXh"><p class="pb-2"><em>This article originally appeared on <a target="_blank" href="https://www.cancernetwork.com/view/early-ct-lung-cancer-screening-significantly-improves-survival-in-lung-cancer">CancerNetwork</a><sup class="text-inherit">®</sup>.</em></p><p class="pb-2"></p><p class="pb-2">Low-dose computed tomography (CT) screening was found to significantly improve the cure rate for patients with <a target="_blank" href="https://www.ajmc.com/compendium/lung-cancer">lung cancer</a>, according to a <a rel="nofollow noreferrer noopener" target="_blank" href="https://www.mountsinai.org/about/newsroom/2022/lung-cancer-screening-dramatically-increases-long-term-survival-rate">study</a> led by Mount Sinai researchers.<sup class="text-inherit">1</sup></p><p class="pb-2"></p><div class=""><div style="width:30%;float:right;max-width:525px;margin:0 0 1.5rem 1.5rem;clear:both;cursor:pointer" class=" figure"><div class="flex-none relative text-center"><span style="box-sizing:border-box;display:inline-block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative;max-width:100%"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;max-width:100%"><img style="display:block;max-width:100%;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0" alt="" aria-hidden="true" src="data:image/svg+xml,%3csvg%20xmlns=%27http://www.w3.org/2000/svg%27%20version=%271.1%27%20width=%275000%27%20height=%273750%27/%3e"/></span><img alt="Lung cancer illustration | Image credit: SciePro - stock.adobe.com" title="Lung cancer illustration | Image credit: SciePro - stock.adobe.com" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="intrinsic" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain"/><noscript><img alt="Lung cancer illustration | Image credit: SciePro - stock.adobe.com" title="Lung cancer illustration | Image credit: SciePro - stock.adobe.com" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F9f975ae9c2ee542c6552c8d164ca16788f849a8b-5000x3750.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 1x" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F9f975ae9c2ee542c6552c8d164ca16788f849a8b-5000x3750.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="intrinsic" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain" loading="lazy"/></noscript></span></div><div id="image-caption" class="text-gray-500 italic"><div class="blockText_blockContent__TbCXh"><p class="pb-2">Lung cancer illustration | Image credit: SciePro - stock.adobe.com</p></div></div><div class="top-[-100%] block w-[1px] transition-opacity duration-500 ease-in-out opacity-0 overflow-hidden"><img class="m-auto absolute inset-0 max-w-[0%] max-h-[0%] border-[3px] border-solid border-white shadow-[0px_0px_8px_rgba(0,0,0,0.3)] box-border transition ease-in-out duration-500" src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9f975ae9c2ee542c6552c8d164ca16788f849a8b-5000x3750.jpg?fit=crop&auto=format"/></div></div><style> #image-caption p{ font-size: 12px; max-width: 525px; margin: 0 auto; text-align: center; } </style></div><p class="pb-2">Results demonstrated a 10-year lung cancer–specific survival rate of 81% (95% CI, 79%-84%) and a 20-year lung cancer–specific survival rate of 81% (95% CI, 78%-83%) in patients who were diagnosed with lung cancer through early CT screening. Among patients who were diagnosed with stage I disease (≤10mm), the survival rate was 95% (95% CI, 91%-98%).<sup class="text-inherit">2</sup></p><p class="pb-2"></p><p class="pb-2">“While screening doesn’t prevent cancers from occurring, it is the major tool to identify lung cancers in their earliest stage when they can be cured,” lead study author, Claudia Henschke, MD, PhD, professor of diagnostic, molecular and interventional radiology and director of the Early Lung and Cardiac Action Program (ELCAP) at the Icahn School of Medicine at Mount Sinai in New York said in the press release. “Ultimately, anyone interested in being screened needs to know that if they are unfortunate enough to develop lung cancer, it can be cured if found early.”</p><p class="pb-2"></p><p class="pb-2">Currently, less than 6% of the population that is eligible for screening receives it.</p><p class="pb-2"></p><p class="pb-2">International ELCAP (I-ELCAP) is a multicenter, global research program where a total of 89,404 patients underwent lung cancer screening between 1992 and 2022. Of that population, 1257 patients were diagnosed with first primary lung cancer, either non–small cell lung cancer or small cell lung cancer, regardless of stage or type of treatment. Patients were required to be over the age of 40 years and have been a smoker or exposed to smoking. A total 684 patients were male, and the median age was 66 years (IQR, 61-72). The median duration of follow-up was 105 months (IQR, 41-182).</p><p class="pb-2"></p><p class="pb-2">The Kaplan-Meier survival analysis was used to calculate 10- and 20-year lung cancer-specific survival rates through annual screening. The program found that the Kaplan-Meier survival plateau was reached 10 years after diagnosis.</p><p class="pb-2"></p><p class="pb-2">The patients within the study were also separated into 3 categories of smoking. The 20-year survival rate of those who smoked or were exposed to secondhand smoke for less than 10 years was 85% (95% CI, 78%-91%). The survival rate for those who smoked 10 to 9 years was 83% (95% CI, 77%-89%). In those who smoked for over 30 years, the survival rate was 79% (95% CI, 77%-82%).</p><p class="pb-2"></p><p class="pb-2">I-ELCAP was based off ELCAP (NCT00047385), the domestic version of this screening program, which started in 1992.<sup class="text-inherit">3</sup> There, 1000 patients who were at least 60 years old, had a cigarette smoking history of 10 years, and showed no symptoms of cancer were entered into a program that compared annual low-dose CT with annual chest radiography. Low-dose CT screening detected non-calcified nodules in 23% (95% CI, 21%-26%) of patients; chest radiography detected 7% (5%-9%). CT screening also detected malignant disease in 2.7% (1.8%-3.8%) of patients; chest radiography detected 0.7% (0.3%-1.3%).</p><p class="pb-2"></p><p class="pb-2"><strong>References</strong></p><p class="pb-2">1. Mount Sinai Health System. Lung cancer screening dramatically increases long-term survival rate. News release. Mount Sinai Health System. Published November 2, 2022. Accessed November 7, 2023. https://tinyurl.com/ya47vx8y</p><p class="pb-2">2. Henschke CI, Yip R, Shaham, D, et al. A 20-year follow-up of the International Early Lung Cancer Action Program (I-ELCAP). Radiology. 2023;309(2):e231988. doi:10.1148/radiol.231988</p><p class="pb-2">3. Henschke CI, McCauley DI, Yankelevitz DF, et al. Early Lung Cancer Action Project: overall design and findings from baseline screening. Lancet. 1999;354(9173):99-105. doi:10.1016/s0140-6736(99)06093-6</p><p class="pb-2"></p><p class="pb-2"></p></div></div><div class="flex items-center lg:w-3/4 mb-4 pb-12"></div><div class="jsx-19ede9f0a5a45918 py-4 relative bg-primary md:px-8 -ml-6 xs:ml-0 w-screen xs:w-auto"><div class="jsx-19ede9f0a5a45918 px-4 sm:px-0"><div class="flex justify-between items-center py-1 space-x-4 border-0 select-none sm:border-b border-secondary"><div class="text-3xl text-white text-lg sm:text-3xl">Related Videos</div></div></div><div style="scroll-snap-type:none" class="jsx-19ede9f0a5a45918 flex items-start overflow-x-auto space-x-4 py-4 relative mx-auto w-full pl-4"><a id="" class="w-[200px] h-fit space-y-3 flex-none select-none no-underline" style="scroll-snap-align:center;text-decoration:none" href="/view/breast-cancer-challenges-and-promises-in-immunotherapy"><div class="w-full shadow-md shadow-gray-800 overflow-hidden relative bg-white aspect-video"><span 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src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F8057e8cb99d8167daf75484374b6006fa2671fd6-955x524.png%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=30" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain" loading="lazy"/></noscript></span></div><div class="w-full flex-wrap text-center text-sm mt-4 font-light no-underline text-white"></div></a><a id="" class="w-[200px] h-fit space-y-3 flex-none select-none no-underline" style="scroll-snap-align:center;text-decoration:none" href="/view/dr-tetyana-kendzerska-chest-data-highlight-connection-between-sleep-apnea-and-mental-health"><div class="w-full shadow-md shadow-gray-800 overflow-hidden relative bg-white aspect-video"><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img alt="Tetyana Kendzerska, MD" title="Tetyana Kendzerska, MD" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain"/><noscript><img alt="Tetyana Kendzerska, MD" title="Tetyana Kendzerska, MD" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F0c8907140f17643eb736b83e4281230364e40ca6-817x450.png%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=30 640w, 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/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F0c8907140f17643eb736b83e4281230364e40ca6-817x450.png%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=30 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F0c8907140f17643eb736b83e4281230364e40ca6-817x450.png%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=30 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F0c8907140f17643eb736b83e4281230364e40ca6-817x450.png%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=30" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain" loading="lazy"/></noscript></span></div><div class="w-full flex-wrap text-center text-sm mt-4 font-light no-underline text-white"></div></a></div></div><div class="relative block sm:hidden"><div class="mt-4 overflow-hidden"><div class="flex justify-between"><div class="flex items-center clear-both pt-4 pb-2 text-3xl lg:text-2xl xl:text-3xl min-w-fit ">Related Content </div><div class="hidden lg:flex w-full flex-col justify-end items-end"><div class="hidden w-full lg:flex flex-wrap pb-2 gap-x-2 gap-y-1 justify-end items-end"></div></div></div><div class="w-full mb-2 border border-secondary"></div><div class="lg:hidden flex flex-wrap items-center"></div><div class="flex flex-wrap w-full"><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-1"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/2025-gold-report-new-insights-on-copd-risks-management?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/6418bb32610c66a6b058609e8b3c2d21368ccb96-4200x3900.jpg?fit=crop&auto=format" alt="COPD illustration | Image Credit: peterschreiber.media - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 27th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/2025-gold-report-new-insights-on-copd-risks-management?utm_source=www.ajmc.com&utm_medium=relatedContent">2025 GOLD Report: New Insights on COPD Risks, Management</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/tim-smith">Tim Smith</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/2025-gold-report-new-insights-on-copd-risks-management?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The 2025 Global Initiative for Chronic Obstructive Lung Disease (GOLD) report highlighted climate change, cardiovascular risk, and pulmonary hypertension.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/operationalizing-bispecifics-in-multiple-myeloma?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9de113904a026205cbaf84d08420c4065d52fd67-1000x563.jpg?fit=crop&auto=format" alt="managed care cast logo" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 27th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/operationalizing-bispecifics-in-multiple-myeloma?utm_source=www.ajmc.com&utm_medium=relatedContent">Operationalizing Bispecifics in Multiple Myeloma</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/mary-caffrey">Mary Caffrey</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/laura-joszt">Laura Joszt, MA</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/operationalizing-bispecifics-in-multiple-myeloma?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Tyler Sandahl, PharmD, of Mayo Clinic, and Michael Byrne, DO, of Tennessee Oncology, discuss practical advice for bringing bispecifics to the community.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-imatinib-oral-solution-for-treatment-of-various-cancers?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/f1f12e9d502c73f75e8062c6dd726c422c8aff78-4320x3473.jpg?fit=crop&auto=format" alt="FDA Approval | image credit: gomixer - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-imatinib-oral-solution-for-treatment-of-various-cancers?utm_source=www.ajmc.com&utm_medium=relatedContent">FDA Approves Imatinib Oral Solution for Treatment of Various Cancers</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-imatinib-oral-solution-for-treatment-of-various-cancers?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The FDA approval marks the first oral solution indicated for patients with different forms of leukemia. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/expert-insights-on-how-utilization-management-drives-physician-burnout?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9de113904a026205cbaf84d08420c4065d52fd67-1000x563.jpg?fit=crop&auto=format" alt="managed care cast logo" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/expert-insights-on-how-utilization-management-drives-physician-burnout?utm_source=www.ajmc.com&utm_medium=relatedContent">Expert Insights on How Utilization Management Drives Physician Burnout</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/expert-insights-on-how-utilization-management-drives-physician-burnout?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">On this episode of Managed Care Cast, we speak with the author of a study published in the November 2024 issue of The American Journal of Managed Care® to explore the link between utilization management and physician burnout. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/covid-19-infection-raises-myasthenia-gravis-exacerbation-risk-study-finds?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/e16c42f428ff1dae499535cfedd861067c30dce4-4096x4096.jpg?fit=crop&auto=format" alt="Respiratory infections like COVID-19 are known to exacerbate MG | image credit: Cutie - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 22nd 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/covid-19-infection-raises-myasthenia-gravis-exacerbation-risk-study-finds?utm_source=www.ajmc.com&utm_medium=relatedContent">COVID-19 Infection Raises Myasthenia Gravis Exacerbation Risk, Study Finds</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/kimberly-rath-pharmd">Kimberly Rath, PharmD</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/covid-19-infection-raises-myasthenia-gravis-exacerbation-risk-study-finds?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A new study shows that COVID-19 infection significantly increases the risk of exacerbation in patients with myasthenia gravis (MG). </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/to-improve-clinical-trial-equity-in-multiple-myeloma-just-ask?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/3e665a0c15a17fc3c7ade987a36f77617f865715-437x115.jpg?fit=crop&auto=format" alt="To Improve Clinical Trial Equity in Multiple Myeloma, Just Ask" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 22nd 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/to-improve-clinical-trial-equity-in-multiple-myeloma-just-ask?utm_source=www.ajmc.com&utm_medium=relatedContent">To Improve Clinical Trial Equity in Multiple Myeloma, Just Ask</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/mary-caffrey">Mary Caffrey</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/to-improve-clinical-trial-equity-in-multiple-myeloma-just-ask?utm_source=www.ajmc.com&utm_medium=relatedContent"></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div></div></div></div><div class="relative hidden sm:block"><div class="mt-4 overflow-hidden"><div class="flex justify-between"><div class="flex items-center clear-both pt-4 pb-2 text-3xl lg:text-2xl xl:text-3xl min-w-fit ">Related Content </div><div class="hidden lg:flex w-full flex-col justify-end items-end"><div class="hidden w-full lg:flex flex-wrap pb-2 gap-x-2 gap-y-1 justify-end items-end"></div></div></div><div class="w-full mb-2 border border-secondary"></div><div class="lg:hidden flex flex-wrap items-center"></div><div class="flex flex-wrap w-full"><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-1"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/2025-gold-report-new-insights-on-copd-risks-management?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/6418bb32610c66a6b058609e8b3c2d21368ccb96-4200x3900.jpg?fit=crop&auto=format" alt="COPD illustration | Image Credit: peterschreiber.media 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href="/view/2025-gold-report-new-insights-on-copd-risks-management?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The 2025 Global Initiative for Chronic Obstructive Lung Disease (GOLD) report highlighted climate change, cardiovascular risk, and pulmonary hypertension.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/operationalizing-bispecifics-in-multiple-myeloma?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9de113904a026205cbaf84d08420c4065d52fd67-1000x563.jpg?fit=crop&auto=format" alt="managed care cast logo" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 27th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/operationalizing-bispecifics-in-multiple-myeloma?utm_source=www.ajmc.com&utm_medium=relatedContent">Operationalizing Bispecifics in Multiple Myeloma</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/mary-caffrey">Mary Caffrey</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/laura-joszt">Laura Joszt, MA</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/operationalizing-bispecifics-in-multiple-myeloma?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Tyler Sandahl, PharmD, of Mayo Clinic, and Michael Byrne, DO, of Tennessee Oncology, discuss practical advice for bringing bispecifics to the community.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-imatinib-oral-solution-for-treatment-of-various-cancers?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/f1f12e9d502c73f75e8062c6dd726c422c8aff78-4320x3473.jpg?fit=crop&auto=format" alt="FDA Approval | image credit: gomixer - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-imatinib-oral-solution-for-treatment-of-various-cancers?utm_source=www.ajmc.com&utm_medium=relatedContent">FDA Approves Imatinib Oral Solution for Treatment of Various Cancers</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-imatinib-oral-solution-for-treatment-of-various-cancers?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The FDA approval marks the first oral solution indicated for patients with different forms of leukemia. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/expert-insights-on-how-utilization-management-drives-physician-burnout?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9de113904a026205cbaf84d08420c4065d52fd67-1000x563.jpg?fit=crop&auto=format" alt="managed care cast logo" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/expert-insights-on-how-utilization-management-drives-physician-burnout?utm_source=www.ajmc.com&utm_medium=relatedContent">Expert Insights on How Utilization Management Drives Physician Burnout</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/expert-insights-on-how-utilization-management-drives-physician-burnout?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">On this episode of Managed Care Cast, we speak with the author of a study published in the November 2024 issue of The American Journal of Managed Care® to explore the link between utilization management and physician burnout. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/covid-19-infection-raises-myasthenia-gravis-exacerbation-risk-study-finds?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/e16c42f428ff1dae499535cfedd861067c30dce4-4096x4096.jpg?fit=crop&auto=format" alt="Respiratory infections like COVID-19 are known to exacerbate MG | image credit: Cutie - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 22nd 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/covid-19-infection-raises-myasthenia-gravis-exacerbation-risk-study-finds?utm_source=www.ajmc.com&utm_medium=relatedContent">COVID-19 Infection Raises Myasthenia Gravis Exacerbation Risk, Study Finds</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/kimberly-rath-pharmd">Kimberly Rath, PharmD</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/covid-19-infection-raises-myasthenia-gravis-exacerbation-risk-study-finds?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A new study shows that COVID-19 infection significantly increases the risk of exacerbation in patients with myasthenia gravis (MG). </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/to-improve-clinical-trial-equity-in-multiple-myeloma-just-ask?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/3e665a0c15a17fc3c7ade987a36f77617f865715-437x115.jpg?fit=crop&auto=format" alt="To Improve Clinical Trial Equity in Multiple Myeloma, Just Ask" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 22nd 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/to-improve-clinical-trial-equity-in-multiple-myeloma-just-ask?utm_source=www.ajmc.com&utm_medium=relatedContent">To Improve Clinical Trial Equity in Multiple Myeloma, Just Ask</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/mary-caffrey">Mary Caffrey</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/to-improve-clinical-trial-equity-in-multiple-myeloma-just-ask?utm_source=www.ajmc.com&utm_medium=relatedContent"></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div></div></div></div><div class="pb-24"></div></div><script type="application/ld+json">{"@context":"https://schema.org","@type":"NewsArticle","headline":"Early CT Screening Significantly Improves Survival in Lung Cancer","datePublished":"2023-11-28T13:30:00.000Z","dateModified":"2023-11-25T16:19:32Z","inLanguage":"en-US","image":"https://cdn.sanity.io/images/0vv8moc6/ajmc/9f975ae9c2ee542c6552c8d164ca16788f849a8b-5000x3750.jpg?fit=crop&auto=format","mainEntityOfPage":{"@type":"WebPage","@id":"https://www.ajmc.com/view/early-ct-screening-significantly-improves-survival-in-lung-cancer"},"publisher":{"@type":"Organization","name":"AJMC","logo":{"@type":"ImageObject","url":"https://www.ajmc.com/ajmc_logo_inverted.png"}},"keywords":"lung cancer screening,lung cancer","articleBody":"This article originally appeared on CancerNetwork®.\n\n\n\nLow-dose computed tomography (CT) screening was found to significantly improve the cure rate for patients with lung cancer, according to a study led by Mount Sinai researchers.1\n\n\n\n\n\nResults demonstrated a 10-year lung cancer–specific survival rate of 81% (95% CI, 79%-84%) and a 20-year lung cancer–specific survival rate of 81% (95% CI, 78%-83%) in patients who were diagnosed with lung cancer through early CT screening. Among patients who were diagnosed with stage I disease (≤10mm), the survival rate was 95% (95% CI, 91%-98%).2\n\n\n\n“While screening doesn’t prevent cancers from occurring, it is the major tool to identify lung cancers in their earliest stage when they can be cured,” lead study author, Claudia Henschke, MD, PhD, professor of diagnostic, molecular and interventional radiology and director of the Early Lung and Cardiac Action Program (ELCAP) at the Icahn School of Medicine at Mount Sinai in New York said in the press release. “Ultimately, anyone interested in being screened needs to know that if they are unfortunate enough to develop lung cancer, it can be cured if found early.”\n\n\n\nCurrently, less than 6% of the population that is eligible for screening receives it.\n\n\n\nInternational ELCAP (I-ELCAP) is a multicenter, global research program where a total of 89,404 patients underwent lung cancer screening between 1992 and 2022. Of that population, 1257 patients were diagnosed with first primary lung cancer, either non–small cell lung cancer or small cell lung cancer, regardless of stage or type of treatment. Patients were required to be over the age of 40 years and have been a smoker or exposed to smoking. A total 684 patients were male, and the median age was 66 years (IQR, 61-72). The median duration of follow-up was 105 months (IQR, 41-182).\n\n\n\nThe Kaplan-Meier survival analysis was used to calculate 10- and 20-year lung cancer-specific survival rates through annual screening. The program found that the Kaplan-Meier survival plateau was reached 10 years after diagnosis.\n\n\n\nThe patients within the study were also separated into 3 categories of smoking. The 20-year survival rate of those who smoked or were exposed to secondhand smoke for less than 10 years was 85% (95% CI, 78%-91%). The survival rate for those who smoked 10 to 9 years was 83% (95% CI, 77%-89%). In those who smoked for over 30 years, the survival rate was 79% (95% CI, 77%-82%).\n\n\n\nI-ELCAP was based off ELCAP (NCT00047385), the domestic version of this screening program, which started in 1992.3 There, 1000 patients who were at least 60 years old, had a cigarette smoking history of 10 years, and showed no symptoms of cancer were entered into a program that compared annual low-dose CT with annual chest radiography. Low-dose CT screening detected non-calcified nodules in 23% (95% CI, 21%-26%) of patients; chest radiography detected 7% (5%-9%). CT screening also detected malignant disease in 2.7% (1.8%-3.8%) of patients; chest radiography detected 0.7% (0.3%-1.3%).\n\n\n\nReferences\n\n1. Mount Sinai Health System. Lung cancer screening dramatically increases long-term survival rate. News release. Mount Sinai Health System. Published November 2, 2022. Accessed November 7, 2023. https://tinyurl.com/ya47vx8y\n\n2. Henschke CI, Yip R, Shaham, D, et al. A 20-year follow-up of the International Early Lung Cancer Action Program (I-ELCAP). Radiology. 2023;309(2):e231988. doi:10.1148/radiol.231988\n\n3. Henschke CI, McCauley DI, Yankelevitz DF, et al. Early Lung Cancer Action Project: overall design and findings from baseline screening. Lancet. 1999;354(9173):99-105. doi:10.1016/s0140-6736(99)06093-6\n\n\n\n","description":"Early CT screening leads to a 20-year lung cancer survival rate of 81%.\n","author":[{"@type":"Person","name":"Rina Lokaj"}]}</script></div></div><div class="flex-none w-[300px] z-[9999] relative hidden md:block"><div style="top:5rem" class="sticky custom-spacing"><div class="collapse-container " style="overflow:hidden;max-height:900px;transition:max-height .4s ease-in-out"></div></div></div></div><div id="div-gpt-ad-pixel" style="width:1px;height:1px" class=""></div><noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-NK5KQXS" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript><div id="footerOuterWrap" class=" mx-auto flex"><div class="bg-[#00598D] xl:w-[70%] w-[70%] py-12 pl-auto"><div class="xxl:w-[75%] w-[90%] ml-auto"><div><span 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Shorla Oncology announces FDA approval of IMKELDI (imatinib) oral solution, an oral liquid for the treatment of certain forms of leukemia and other cancers. News release. Shorla Oncology. November 25, 2024. Accessed November 26, 2024. ","_key":"fcc66983d1cc0"},{"_type":"span","marks":["ae7780cb14be"],"text":"https://www.businesswire.com/news/home/20241125044117/en/Shorla-Oncology-Announces-FDA-Approval-of-IMKELDI-imatinib-Oral-Solution-an-Oral-Liquid-for-the-Treatment-of-Certain-Forms-of-Leukemia-and-Other-Cancers","_key":"fcc66983d1cc1"}],"_type":"block","style":"normal","_key":"2e3ed5d87cb6","markDefs":[{"blank":true,"_type":"link","href":"https://www.businesswire.com/news/home/20241125044117/en/Shorla-Oncology-Announces-FDA-Approval-of-IMKELDI-imatinib-Oral-Solution-an-Oral-Liquid-for-the-Treatment-of-Certain-Forms-of-Leukemia-and-Other-Cancers","_key":"ae7780cb14be","nofollow":true}]},{"_key":"9fb30d9db5a8","markDefs":[{"_key":"1721013932bc","nofollow":true,"blank":true,"_type":"link","href":"https://www.cancer.org/cancer/types/acute-lymphocytic-leukemia/about/key-statistics.html"}],"children":[{"_type":"span","marks":[],"text":"2. Key statistics for acute lymphoblastic leukemia (ALL). American Cancer Society. Updated January 17, 2024. Accessed November 26, 2024. ","_key":"7118d79650890"},{"marks":["1721013932bc"],"text":"https://www.cancer.org/cancer/types/acute-lymphocytic-leukemia/about/key-statistics.html","_key":"7118d79650891","_type":"span"}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"26fb2630c5a9","markDefs":[],"children":[{"marks":[],"text":"3. Ravandi F. Managing Philadelphia chromosome-positive acute lymphoblastic leukemia: role of tyrosine kinase inhibitors. ","_key":"7b8e2d60de4e0","_type":"span"},{"_type":"span","marks":["em"],"text":"Clin Lymphoma Myeloma Leuk","_key":"7b8e2d60de4e1"},{"_type":"span","marks":[],"text":". 2011;11(2):198-203. doi:10.1016/j.clml.2011.03.002","_key":"7b8e2d60de4e2"}]},{"markDefs":[{"nofollow":true,"blank":true,"_type":"link","href":"https://www.mayoclinic.org/drugs-supplements/imatinib-oral-route/description/drg-20068331","_key":"36e2d5ea89d7"}],"children":[{"text":"4. Imatinib (oral route). Mayo Clinic. 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","body":[{"style":"normal","_key":"ad3c3b18bdbf","markDefs":[{"blank":true,"_type":"link","href":"https://www.ajmc.com/compendium/myasthenia-gravis","_key":"4840eabe04df"},{"_type":"link","href":"https://onlinelibrary.wiley.com/doi/10.1002/brb3.70074","_key":"b1f6be191129","nofollow":true,"blank":true}],"children":[{"_type":"span","marks":[],"text":"A recent study at the Medical Center of Southwest China suggests that COVID-19 Omicron infection increases the risk of an exacerbation in patients with ","_key":"9536ae64a5fc0"},{"_type":"span","marks":["4840eabe04df"],"text":"myasthenia gravis (MG)","_key":"9536ae64a5fc1"},{"text":". Published in ","_key":"9536ae64a5fc2","_type":"span","marks":[]},{"marks":["b1f6be191129","em"],"text":"Brain and Behavior","_key":"9536ae64a5fc3","_type":"span"},{"marks":[],"text":", the study adds to the growing body of evidence that infections can significantly impact the risk of exacerbations in patients with autoimmune disorders like MG.","_key":"9536ae64a5fc4","_type":"span"},{"_type":"span","marks":["superscript"],"text":"1","_key":"6bd3648f26f9"}],"_type":"block"},{"alignment":"left","alt":"Respiratory infections like COVID-19 are known to exacerbate MG | image credit: Vibu design gallery - stock.adobe.com","asset":{"_type":"reference","_ref":"image-ab621c3c59b3aa8a2f04ea44e2fe654215288eb7-5376x3584-jpg"},"disableLightBox":true,"widthP":30,"imgcaption":[{"_key":"03397da8be52","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Respiratory infections like COVID-19 are known to exacerbate MG | image credit: Vibu design gallery - stock.adobe.com","_key":"a92c989c06860"}],"_type":"block","style":"normal"}],"_type":"figure","_key":"65a7462537bd","disableTextWrap":false},{"style":"normal","_key":"7cc4c947f259","markDefs":[],"children":[{"text":"The observational study collected information on COVID-19 infections and exacerbations of 289 patients with MG during China’s widespread Omicron wave between December 2022 and early 2023. Patients in this cohort were predominantly female (60%), with an average age of 46. According to the study, 234 (80.9%) participants contracted COVID-19. The course of infection was generally mild, with 88% of COVID-19 cases classified as low severity (stages 1-3). Common symptoms included respiratory issues in 50% of infected patients and systemic symptoms like fatigue and headache in 74.4%.","_key":"61c8cc59c5cd0","_type":"span","marks":[]}],"_type":"block"},{"_key":"5e6739d41d1b","markDefs":[],"children":[{"text":"","_key":"e349e86acd060","_type":"span","marks":[]}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"“MG patients with COVID-19 infection exhibited a higher likelihood of exacerbation, compared to those without COVID-19 infection,” the study finds, with exacerbation rates recorded at 18.8% among infected patients versus 7.3% in the non-infected group (P = .039). After adjusting for confounding factors, the hazard ratio for exacerbation in patients with MG post-infection was found to be 3.38 (95% CI, 1.20–9.53; ","_key":"c90bbaee49bc0"},{"_key":"bb20553304a6","_type":"span","marks":["em"],"text":"P"},{"_type":"span","marks":[],"text":" = .021).","_key":"62e0a5fbf3c2"}],"_type":"block","style":"normal","_key":"ec6fb8e1e90a"},{"_key":"63a5e40371ec","markDefs":[],"children":[{"marks":[],"text":"","_key":"1801749c00270","_type":"span"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_key":"a230552b05790","_type":"span","marks":[],"text":"In infected patients, MG exacerbations developed quickly after contracting COVID-19, with a median onset time of just 14 days post-infection (interquartile range, 3-24 days). Exacerbations were evaluated based on changes in the Myasthenia Gravis Activities of Daily Living (MG-ADL) scale, with a worsening of at least 2 points considered an exacerbation. Exacerbations were found to be more severe among patients with MG who had comorbidities and those receiving immunosuppressive therapy, such as corticosteroids."}],"_type":"block","style":"normal","_key":"ed433cadbb3f"},{"_key":"88f945190704","markDefs":[],"children":[{"_key":"523a2b7424580","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Most COVID-19 infections were primarily managed at home, but a few cases required hospitalization. Eight patients with COVID-19 infection (3.4%) developed respiratory failure that required mechanical ventilation, and 3 patients were admitted to the ICU. No deaths were reported within this cohort. However, 14.9% of patients experienced prolonged symptoms of fatigue, tiredness, and shortness of breath.","_key":"a8247d692e3d0"}],"_type":"block","style":"normal","_key":"e821e7210a86"},{"_type":"block","style":"normal","_key":"4772327b8df1","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"7b39509e0dd00"}]},{"style":"normal","_key":"94f7576911ed","markDefs":[],"children":[{"marks":[],"text":"To further investigate the impact of COVID-19 on patients with MG, the researchers conducted a survival analysis comparing MG exacerbations in 2 time periods: December 1, 2022 to March 10, 2023 (DTM23), covering the Omicron wave, and January 2021 to April 2021 (JTA21), an earlier period without COVID-19 exposure. The comparison indicated an increase in exacerbations during the Omicron outbreak, with a recorded exacerbation rate of 17.2% in DTM23 compared to 4.4% in JTA21 (","_key":"fc23a17ba5bb0","_type":"span"},{"_type":"span","marks":["em"],"text":"P","_key":"565d292c2521"},{"_type":"span","marks":[],"text":" \u003c .001).","_key":"36719ee858e2"}],"_type":"block"},{"children":[{"_key":"62f5bb72dfb70","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"89066828d77a","markDefs":[]},{"_key":"9f68fc8008a2","markDefs":[],"children":[{"marks":[],"text":"No statistically significant differences in COVID-19 vaccination rates were observed between infected and non-infected patients. Although COVID-19 vaccines effectively reduce severe illness, they may offer limited protection against infection with COVID-19 due to the development of unique variants.","_key":"a0d36c7301920","_type":"span"}],"_type":"block","style":"normal"},{"_key":"2ef57ee9e298","markDefs":[],"children":[{"_key":"1fadcdc5e1b20","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal"},{"_key":"b40369efdd6d","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Infection, particularly respiratory infections, has long been known as a trigger for MG exacerbation. This is supported by previous studies showing that viral infections like influenza can similarly increase exacerbation risk.","_key":"effcf725c4820"},{"_type":"span","marks":["superscript"],"text":"2,3","_key":"1b77d53b9173"},{"_type":"span","marks":[],"text":" The results of this study align with recent data from the COVID-19 Associated Risks and Effects in Myasthenia Gravis (CARE-MG) registry that suggests patients with MG infected with COVID-19 are more frequently hospitalized, experience increased disease exacerbations, and have higher mortality rates compared to the general COVID-19 population.","_key":"2574bcdecaaa"},{"text":"4","_key":"98650c5589f8","_type":"span","marks":["superscript"]},{"_type":"span","marks":[],"text":" ","_key":"d8664363b173"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"f4ecd16e57150"}],"_type":"block","style":"normal","_key":"555bffcfee43"},{"_key":"b387cb476159","markDefs":[],"children":[{"_type":"span","marks":[],"text":"It should be noted that in this study, COVID-19 diagnosis was not based strictly on laboratory tests but rather on typical COVID-19 symptoms. 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Three years prior, as the COVID-19 pandemic lingered and the conference remained virtual, Lori Pierce, MD, FASTRO, FASCO, delivered her remarkable Presidential Address, “Equity: Every Patient. Every Day. Everywhere,” which touched on all the ways that overt racism and socioeconomic disparities create gaps in outcomes between White and Black patients.","_key":"d484e77feff70"},{"_type":"span","marks":["superscript"],"text":"1","_key":"340886c2d50e"}],"_type":"block","style":"normal","_key":"2f62f1fa2c32"},{"_key":"837bca01b80b","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Some asked then whether the focus on equity would fade once the pandemic ended and the world returned to normal. However, ","_key":"d120277affce"},{"_type":"span","marks":["em"],"text":"The American Journal of Managed Care","_key":"09a43c5c6f46"},{"_type":"span","marks":[],"text":" vowed to highlight these issues for the long haul through the Center on Health Equity \u0026 Access—and we are keeping that promise. So, we couldn’t ignore how few Black patients were enrolled in a pair of important multiple myeloma trials that had results presented at ASCO.","_key":"8fb55cc302ae"},{"_type":"span","marks":["superscript"],"text":"2","_key":"e53284442299"}],"_type":"block","style":"normal"},{"style":"normal","_key":"d7ed52e524f9","markDefs":[],"children":[{"_type":"span","marks":[],"text":"IMROZ (NCT03319667) and PERSEUS (NCT03710603) involved quadruplet regimens for groups of newly diagnosed patients: 2 different anti-CD38 monoclonal antibodies, each given with a backbone of bortezomib, lenalidomide, and dexamethasone. Results for one study were so promising that an expert asked whether the lines between transplant eligible and transplant ineligible were still needed.","_key":"4a60639aaea5"},{"marks":["superscript"],"text":"2","_key":"3ec066a6e790","_type":"span"}],"_type":"block"},{"_key":"33ca6d8f0380","markDefs":[],"children":[{"_type":"span","marks":[],"text":"These 2 trials could markedly shift care for many of the 35,000-plus individuals in the US who are annually diagnosed with multiple myeloma, which is well known to disproportionately affect the Black patient population. In a decade, Black patients will account for one-quarter of those newly diagnosed with myeloma in the US.","_key":"b050f76f8342"}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"fe3126b5f3dc","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Just as IMROZ and PERSEUS were launching, the FDA warned that among all patients enrolled in myeloma trials for drug indications between 2003 and 2017, only 4.5% were Black. The trials opened, and together they randomized 1155 patients. Thirteen were Black.","_key":"55682920efa2"}]},{"_type":"block","style":"normal","_key":"33c7dcd538e6","markDefs":[],"children":[{"_key":"327f69fef505","_type":"span","marks":[],"text":"The explanation that Flinn received in his reporting is that location matters. Trials based outside the US, especially those centered in Europe, were more likely to have a larger enrollment of White patients. Testing sites in the US are more diverse. When we reached Joseph Mikhael, MD, an expert and advocate in this area and the chief medical officer for the International Myeloma Foundation, he said that efforts are ongoing to address the different metrics that emerge from European-based trials. But it really comes down to FDA asking the right questions."}]},{"_key":"f8e5593941a7","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The FDA is taking notice. In June, it issued a draft guidance for the industry on Diversity Action Plans that would be required for certain clinical studies. The question is: What happens next?","_key":"ae1713f6ab71"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"marks":[],"text":"At a May forum hosted by Citeline, Bob Zambon, a vice president for Syneos Health, said nothing will propel change more than the FDA telling a company “no” over lack of diversity. “What will drive this most of all,” Zambon said, “is the FDA saying, ‘Either do it or we’re not going to approve your drug.’”","_key":"ee2068a6996a","_type":"span"},{"marks":["superscript"],"text":"3","_key":"1ff412e35fa8","_type":"span"}],"_type":"block","style":"normal","_key":"dad826a2568d"},{"_type":"block","style":"normal","_key":"f2e7783714ea","markDefs":[],"children":[{"marks":[],"text":"Change means identifying the barriers to participation and taking them on. It means going to where the patients are. It means making connections with community leaders who patients trust, such as pastors or primary care physicians. It means working with community oncologists to bring trials into remote areas. It also means not making assumptions about who can be in a trial, Pierce said.","_key":"c3431fd94816","_type":"span"}]},{"children":[{"_type":"span","marks":[],"text":"“This is not an issue for the public, for the medical community, for the pharmaceutical community, for the regulatory agencies, for the government,” Mikhael said. “It’s really one that involves all of us.”","_key":"5623f5828d9d"}],"_type":"block","style":"normal","_key":"a330335e2901","markDefs":[]},{"markDefs":[],"children":[{"text":"Most of all, as the effort by ASCO and the Association of Cancer Care Centers suggests, it calls on physicians to “just ask.” \n\n","_key":"395e17750805","_type":"span","marks":[]},{"_type":"span","marks":["strong"],"text":"References","_key":"f4e84a0a1501"},{"_type":"span","marks":[],"text":"\n1. Pierce L. 2021 presidential address: equity: every patient. every day. everywhere. ASCO Connection. June 7, 2021. Accessed November 1, 2024. https://connection.asco.org/magazine/features/2021-presidential-address-equity-every-patient-every-day-everywhere\n2. Caffrey M, Shaw ML. Multiple myeloma. ","_key":"473d47d7a475"},{"_type":"span","marks":["em"],"text":"Am J Manag Care","_key":"f1169dcb2b57"},{"_type":"span","marks":[],"text":". 2024;30(Spec 8):SP608-SP617.\n3. Karlin-Smith S. ‘Do it or we’re not going to approve your drug:’ industry reps as FDA for trial diversity sticks. Pink Sheet. May 13, 2024. Accessed October 28, 2024. https://insights.citeline.com/PS154696/Do-It-Or-Were-Not-Going-To-Approve-Your-Drug-Industry-Reps-Ask-FDA-For-Trial-Diversity-Sticks/","_key":"4bef88cc8911"}],"_type":"block","style":"normal","_key":"dec0ba64830f"}],"drugMentions":"{\n \"drug_mentions\": [\"bortezomib\", \"lenalidomide\", \"dexamethasone\"]\n}","seoTag":["clinical trials","multiple myeloma","disparities","health equity","pharmaceuticals"],"ExcludeFromPubMedXML":false,"published":"2024-11-22T12:37:00.000Z","url":"to-improve-clinical-trial-equity-in-multiple-myeloma-just-ask","authorMapping":[{"_createdAt":"2020-05-05T10:50:00Z","_rev":"fWre465xUeSiaQm83HJghZ","_type":"author","_id":"author_6732921f288a3775abb89da57903428b","biography":[{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Mary Caffrey is the Executive Editor for The American Journal of Managed Care® (","_key":"9737335da1ed0"},{"_type":"span","marks":["em"],"text":"AJMC","_key":"b8dda18bb0dc"},{"text":"®). 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