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We partner with other organisations to build robust public tools to provide access to open content and data, and to advance life sciences research. </p></div><div data-v-066b9268="" id="what-is-europe-pmc" class="content-section has-sections"><h2 data-v-066b9268="" id="article--what-is-europe-pmc--header" role="button" tabindex="0" class="section-title"> What is Europe PMC? <span data-v-066b9268="" class="right"><i data-v-066b9268="" class="fas fa-caret-down"></i></span></h2><hr data-v-066b9268="" class="thick"><div data-v-066b9268="" class="section-content"><p data-v-4ebd7b21="" data-v-066b9268=""> Europe PMC provides comprehensive access to life sciences literature from trusted sources. It's available to anyone, anywhere for free. With Europe PMC you can search and read <a data-v-4ebd7b21="" data-v-066b9268="" href="/search?query=SRC:*"> publications, preprints and other documents</a> enriched with links to supporting data, reviews, protocols, and other relevant resources. </p><div data-v-72ffff0a="" data-v-4ebd7b21="" class="video" data-v-066b9268=""><div data-v-72ffff0a="" class="video-container"><img data-v-72ffff0a="" src="/img/what-is-europe-pmc.b5e62f34.jpeg" alt="What is Europe PMC?" loading="lazy"><div data-v-72ffff0a="" class="play"><div data-v-72ffff0a="" class="tri"></div></div><div data-v-72ffff0a="" class="duration"> 1:52 </div></div><div data-v-72ffff0a="" class="video-title"> What is Europe PMC? </div></div></div></div><div data-v-066b9268="" id="who-is-behind-europe-pmc" class="content-section has-sections"><h2 data-v-066b9268="" id="article--who-is-behind-europe-pmc--header" role="button" tabindex="0" class="section-title"> Who is behind Europe PMC? <span data-v-066b9268="" class="right"><i data-v-066b9268="" class="fas fa-caret-down"></i></span></h2><hr data-v-066b9268="" class="thick"><div data-v-066b9268="" class="section-content"><p data-v-4ebd7b21="" data-v-066b9268=""> Europe PMC is hosted by EMBL鈥檚 European Bioinformatics Institute (<a data-v-4ebd7b21="" data-v-066b9268="" href="//www.ebi.ac.uk/">EMBL-EBI</a>), an international, innovative and interdisciplinary research organisation which aims to make the world鈥檚 public biological data freely available to the scientific community. Europe PMC is partnered with <a data-v-4ebd7b21="" data-v-066b9268="" href="//www.ncbi.nlm.nih.gov/labs/pmc/about/pmci/">PubMed Central (PMC)</a>, and endorsed and supported by a group of <a data-v-4ebd7b21="" data-v-066b9268="" href="/Funders">international science funders</a> as their repository of choice. </p><div data-v-4ebd7b21="" data-v-066b9268="" id="partners-logos"><a data-v-4ebd7b21="" data-v-066b9268="" href="//www.ebi.ac.uk" aria-label="EMBL-EBI"><img data-v-4ebd7b21="" data-v-066b9268="" id="ebi-logo" src="/img/embl-ebi.9db652cf.jpg" alt="EMBL-EBI"></a><a data-v-4ebd7b21="" data-v-066b9268="" href="//www.ncbi.nlm.nih.gov/labs/pmc/"><img data-v-4ebd7b21="" data-v-066b9268="" id="pubmed-central-logo" src="/img/pubmed-central.1fea3e10.png" alt="PubMed Central"></a></div><p data-v-4ebd7b21="" data-v-066b9268=""> Europe PMC works closely with partner organisations to build open, full text scientific literature resources and support innovation by engaging users, enabling contributors, and integrating related research data. </p></div></div><div data-v-066b9268="" id="why-use-europe-pmc" class="content-section has-sections"><h2 data-v-066b9268="" id="article--why-use-europe-pmc--header" role="button" tabindex="0" class="section-title"> Why use Europe PMC? <span data-v-066b9268="" class="right"><i data-v-066b9268="" class="fas fa-caret-down"></i></span></h2><hr data-v-066b9268="" class="thick"><div data-v-066b9268="" class="section-content"><p data-v-4ebd7b21="" data-v-066b9268="" class="h3"> Access a wealth of life sciences research, including preprints </p><p data-v-4ebd7b21="" data-v-066b9268=""> Europe PMC contains <a data-v-4ebd7b21="" data-v-066b9268="" href="/search?query=SRC:*"> abstracts</a> and <a data-v-4ebd7b21="" data-v-066b9268="" href="/search?query=HAS_FT:Y"> full text articles</a>, including research articles, preprints, micropublications, books, reviews, and protocols. Europe PMC integrates content from a range of sources such as PubMed, PubMed Central (PMC), Agricola, and 34 life science preprint servers including biorxiv, Research Square, and Preprints.org. See <a data-v-4ebd7b21="" data-v-066b9268="" href="/Preprints">Preprints in Europe PMC</a> for more information about the integration of preprints, and the COVID-19 preprints full text initiative. When the full text is not available, Europe PMC can provide extended access to full text, with links to legal free copies via <a data-v-4ebd7b21="" data-v-066b9268="" href="http://blog.europepmc.org/2018/04/unlocking-open-europe-pmc-integrates.html">Unpaywall</a>. </p><p data-v-4ebd7b21="" data-v-066b9268="" class="h3"> Connect research articles with other research resources </p><p data-v-4ebd7b21="" data-v-066b9268=""> Research articles in Europe PMC are linked to data behind the paper, which supports reproducibility. Articles are also linked to protocols, smart citations, peer review materials and more. Preprints versions are linked to each other, and to the journal published version, when possible. </p><div data-v-4ebd7b21="" data-v-066b9268="" id="pub-types-image"><img data-v-4ebd7b21="" data-v-066b9268="" src="/img/pub-types.868df770.svg" alt="Publication types"><span data-v-4ebd7b21="" data-v-066b9268="" id="label1"><br data-v-4ebd7b21="" data-v-066b9268="">research<br data-v-4ebd7b21="" data-v-066b9268="">articles</span><span data-v-4ebd7b21="" data-v-066b9268="" id="label2">External content<br data-v-4ebd7b21="" data-v-066b9268="">& data resources</span><span data-v-4ebd7b21="" data-v-066b9268="" id="label3">Research<br data-v-4ebd7b21="" data-v-066b9268="">enriched<br data-v-4ebd7b21="" data-v-066b9268="">with relevant<br data-v-4ebd7b21="" data-v-066b9268="">resources</span></div><p data-v-4ebd7b21="" data-v-066b9268="" class="h3">Examine data behind the paper</p><p data-v-4ebd7b21="" data-v-066b9268=""> Europe PMC connects publications with high quality data in over 40 biological databases. This includes data that supports the results of the publication, so that you can examine the evidence behind scientific claims and for reproducibility of the results. Europe PMC also includes links to curated biological resources, where you can find out more about the data that cites the publication. Learn more about Data in <a data-v-4ebd7b21="" data-v-066b9268="" href="/Help">Help using Europe PMC</a>. </p><p data-v-4ebd7b21="" data-v-066b9268="" class="h3">Use intuitive and powerful search tools</p><p data-v-4ebd7b21="" data-v-066b9268=""> Based on the latest technologies Europe PMC search helps you discover research evidence even when it is buried deep in the literature. </p><p data-v-4ebd7b21="" data-v-066b9268=""> Compared to other search engines, Europe PMC searches both <a data-v-4ebd7b21="" data-v-066b9268="" href="/search?query=SRC:*">abstracts and full text of over articles</a>, allowing you to find a greater number of relevant results. Our high-performance search tools allow you to customize your queries, enabling you to search specific parameters such as cited articles; articles with open peer reviews or extended protocols; searches limited to clinical trials or preprints, or even to specific article sections, such as Methods or Figures. They help you search for data behind publications and find papers providing biological models, citing proteomics datasets, or describing protein structures. See <a data-v-4ebd7b21="" data-v-066b9268="" href="/advancesearch">Advanced search</a> and <a data-v-4ebd7b21="" data-v-066b9268="" href="/searchsyntax">Search syntax reference</a> for more search options. </p><p data-v-4ebd7b21="" data-v-066b9268=""> In addition, Europe PMC offers the <a data-v-4ebd7b21="" data-v-066b9268="" href="/grantfinder">Grant finder</a> tool to enable searching for biomedical grants from 35 life science funders, as well as grants awarded for COVID-19 related projects. </p><p data-v-4ebd7b21="" data-v-066b9268="" class="h3">Showcase your work</p><p data-v-4ebd7b21="" data-v-066b9268=""> Europe PMC supports researchers with author profile pages that showcase and promote the author's scholarly work. The author profile provides a graphical overview of published articles and preprints, their open access status, as well as their citation rate over time. Author profiles are based on the author's ORCID record. An <a data-v-4ebd7b21="" data-v-066b9268="" href="//orcid.org">ORCID</a> is a unique identifier for research authors. The use of ORCID in Europe PMC makes it possible to refine the author search, and receive suggested authors based on their ORCID record. You can also add articles to your ORCID profile using Europe PMC鈥檚 <a data-v-4ebd7b21="" data-v-066b9268="" href="/orcid/import">ORCID claiming tool</a>. </p><p data-v-4ebd7b21="" data-v-066b9268=""> Europe PMC operates a manuscript submission system (<a data-v-4ebd7b21="" data-v-066b9268="" href="//plus.europepmc.org">Europe PMC plus</a>) on behalf of Europe PMC funders, who recommend or require publications from the research they fund to be made openly available via Europe PMC. Authors supported by Europe PMC funders can deposit their manuscripts for inclusion in Europe PMC and by extension in PubMed Central (PMC) using Europe PMC plus. </p><p data-v-4ebd7b21="" data-v-066b9268="" class="h3">Find annotated biological concepts</p><p data-v-4ebd7b21="" data-v-066b9268=""> Europe PMC uses text mining and machine learning techniques to annotate literature with relevant biological terms and concepts, from chemicals and cell lines, to gene mutations and protein interactions. You can find biological terms in the text by using the Annotations tool to select and find terms for highlighting. Over 1.3 billion annotations covering 42 types of concepts are available. Find out more about <a data-v-4ebd7b21="" data-v-066b9268="" href="/Help#keyterms">Annotations</a>. </p><p data-v-4ebd7b21="" data-v-066b9268="" class="h3">Get results with powerful programmatic tools</p><p data-v-4ebd7b21="" data-v-066b9268=""> Europe PMC provides programmatic access to open content and metadata for building diverse literature-based applications. Europe PMC offers APIs for accessing publications and related information via the <a data-v-4ebd7b21="" data-v-066b9268="" href="/RestfulWebService">Articles API</a>, grant information from Europe PMC funders and COVID-19 related grants via the <a data-v-4ebd7b21="" data-v-066b9268="" href="/GristAPI">Grants API</a>, and text-mined annotations contained in abstracts and open access articles via the <a data-v-4ebd7b21="" data-v-066b9268="" href="/AnnotationsApi">Annotations API</a>. See <a data-v-4ebd7b21="" data-v-066b9268="" href="/developers">Developer resources</a> for a full list of services provided. To make it easier to programmatically search and retrieve specific research outputs, Europe PMC integrates persistent identifiers, such as ORCIDs, Grant DOIs and RORs. </p><p data-v-4ebd7b21="" data-v-066b9268=""> If you would like to see examples of how Europe PMC APIs can be used to create new products and services, please visit <a data-v-4ebd7b21="" data-v-066b9268="" href="/api-case-studies">API case studies</a>. </p><p data-v-4ebd7b21="" data-v-066b9268=""> Europe PMC strongly supports open source development. Open source projects of particular interest to the user community are available on Europe PMC <a data-v-4ebd7b21="" data-v-066b9268="" href="//gitlab.ebi.ac.uk/literature-services/public-projects">GitLab</a> and <a data-v-4ebd7b21="" data-v-066b9268="" href="//github.com/EuropePMC">GitHub</a> pages. </p><p data-v-4ebd7b21="" data-v-066b9268="" class="h3">Take advantage of text-mining resources</p><p data-v-4ebd7b21="" data-v-066b9268=""> For the text-mining community, a range of Europe PMC resources are available as <a data-v-4ebd7b21="" data-v-066b9268="" href="/downloads">bulk downloads</a> via the FTP site: </p><ul data-v-4ebd7b21="" data-v-066b9268=""><li data-v-4ebd7b21="" data-v-066b9268=""><a data-v-4ebd7b21="" data-v-066b9268="" href="//europepmc.org/ftp/pmclitemetadata/">Metadata</a> for all full text articles </li><li data-v-4ebd7b21="" data-v-066b9268=""><a data-v-4ebd7b21="" data-v-066b9268="" href="/downloads/openaccess">Open access subset</a> containing the full text open access articles from PubMed Central, along with supplemental files and figures </li><li data-v-4ebd7b21="" data-v-066b9268=""><a data-v-4ebd7b21="" data-v-066b9268="" href="/downloads/preprints">Preprints subset</a> containing preprint abstracts and full text for preprints on COVID-19 </li><li data-v-4ebd7b21="" data-v-066b9268=""><a data-v-4ebd7b21="" data-v-066b9268="" href="//europepmc.org/ftp/TextMinedTerms">Accession numbers</a> from various life science databases text-mined from publications. </li></ul><p data-v-4ebd7b21="" data-v-066b9268=""> To make text-mining advances widely available for the benefit of the research community Europe PMC has developed a dedicated <a data-v-4ebd7b21="" data-v-066b9268="" href="/AnnotationsSubmission">Annotations Submission System</a>. It allows expert text-mining providers to share their results on the Europe PMC website via the <a data-v-4ebd7b21="" data-v-066b9268="" href="/Annotations#using-annotations">Annotations panel</a> and programmatically through the <a data-v-4ebd7b21="" data-v-066b9268="" href="/AnnotationsApi">Annotations API</a>. The system can also accept relevant statements manually curated by dedicated biocuration groups. </p></div></div><div data-v-066b9268="" id="how-is-europe-pmc-used" class="content-section has-sections"><h2 data-v-066b9268="" id="article--how-is-europe-pmc-used--header" role="button" tabindex="0" class="section-title"> How is Europe PMC used? <span data-v-066b9268="" class="right"><i data-v-066b9268="" class="fas fa-caret-down"></i></span></h2><hr data-v-066b9268="" class="thick"><div data-v-066b9268="" class="section-content"><p data-v-4ebd7b21="" data-v-066b9268=""> Millions of researchers, curators and librarians use Europe PMC for their literature research. Here is why: </p><blockquote data-v-4ebd7b21="" data-v-066b9268=""> I do recommend Europe PMC to the researchers that I meet, because it gives you a better experience than some other search tools for the literature, and you get the full text with it, and it has a lot of added extras, linking out to resources that are relevant. <p data-v-4ebd7b21="" data-v-066b9268="" class="blockquote-source"> Naomi Penfold, Associate Director, ASAPbio </p></blockquote><blockquote data-v-4ebd7b21="" data-v-066b9268=""> To be able to search both the published literature and preprints with the same search terms and in one go that's the real advantage. <p data-v-4ebd7b21="" data-v-066b9268="" class="blockquote-source"> Frank Uhlmann, Group Leader, Francis Crick Institute </p></blockquote><div data-v-72ffff0a="" data-v-4ebd7b21="" class="video" data-v-066b9268=""><div data-v-72ffff0a="" class="video-container"><img data-v-72ffff0a="" src="/img/how-researchers-are-using-europe-pmc.a752be03.jpg" alt="How researchers are using Europe PMC" loading="lazy"><div data-v-72ffff0a="" class="play"><div data-v-72ffff0a="" class="tri"></div></div><div data-v-72ffff0a="" class="duration"> 5:06 </div></div><div data-v-72ffff0a="" class="video-title"> How researchers are using Europe PMC </div></div><p data-v-4ebd7b21="" data-v-066b9268=""> Europe PMC APIs have been used by programmatic users from a host of external parties to do large scale literature analyses, and build diverse applications. These include academic institutes, commercial industries, publishers, funders, infrastructure providers, text mining groups, open science apps and tools, and Research Information (CRIS) systems. Here is why: </p><blockquote data-v-4ebd7b21="" data-v-066b9268=""> We use Europe PMC API in our citation harvesting pipeline. Europe PMC has a well documented, reliable, and production-ready API allowing any user and service to build an open ecosystem of tools that empowers researchers. <p data-v-4ebd7b21="" data-v-066b9268="" class="blockquote-source"> Alex Loannidis, Service manager, Zenodo </p></blockquote><blockquote data-v-4ebd7b21="" data-v-066b9268=""> I have worked with other literature services APIs like Scopus and WoS, but there is no comparison with the service Europe PMC team provides. <p data-v-4ebd7b21="" data-v-066b9268="" class="blockquote-source"> Frederico Lopez Gomez, Web developer, International Mouse Phenotyping Consortium </p></blockquote><p data-v-4ebd7b21="" data-v-066b9268=""> Find out more about <a data-v-4ebd7b21="" data-v-066b9268="" href="/api-case-studies">How people are using Europe PMC APIs</a>. </p></div></div><div data-v-066b9268="" id="what-is-next-for-europe-pmc" class="content-section has-sections"><h2 data-v-066b9268="" id="article--what-is-next-for-europe-pmc--header" role="button" tabindex="0" class="section-title"> What鈥檚 next for Europe PMC? <span data-v-066b9268="" class="right"><i data-v-066b9268="" class="fas fa-caret-down"></i></span></h2><hr data-v-066b9268="" class="thick"><div data-v-066b9268="" class="section-content"><p data-v-4ebd7b21="" data-v-066b9268="">Europe PMC will continue to focus development in these key areas:</p><ul data-v-4ebd7b21="" data-v-066b9268=""><li data-v-4ebd7b21="" data-v-066b9268=""><b data-v-4ebd7b21="" data-v-066b9268="">Publishing innovation</b>: Building on emerging trends in scholarly communication, from including preprints to integrating ORCIDs. </li><li data-v-4ebd7b21="" data-v-066b9268=""><b data-v-4ebd7b21="" data-v-066b9268="">Reproducible science</b>: Supporting open data re-use by linking publications with underlying data. </li><li data-v-4ebd7b21="" data-v-066b9268=""><b data-v-4ebd7b21="" data-v-066b9268="">Text and data mining</b>: Enabling data-driven discovery by offering more efficient ways to read and process scientific literature with the help of text-mining and machine learning technologies. </li></ul><p data-v-4ebd7b21="" data-v-066b9268=""> To learn about Europe PMC鈥檚 mission and objectives, and to view plans for future development visit the <a data-v-4ebd7b21="" data-v-066b9268="" href="/Roadmap">Europe PMC Roadmap</a>. </p><p data-v-4ebd7b21="" data-v-066b9268=""> For detailed information about Europe PMC, read the article <a data-v-4ebd7b21="" data-v-066b9268="" href="/article/MED/33180112">Europe PMC in 2020</a>. </p></div></div></div></div><div class="grid-row"><div class="col-16"><div data-v-466b8079="" data-v-4ebd7b21="" id="supporters-section"><hr data-v-466b8079="" class="thick"><p data-v-466b8079="" class="h2">Supported by</p><p data-v-466b8079=""> Support by a group of international science <a data-v-466b8079="" href="/Funders">Funders</a> makes Europe PMC possible. </p><div data-v-466b8079="" id="supporters"><a data-v-466b8079="" href="//www.acmedsci.ac.uk/" aria-label="The Academy of Medical Sciences"><img data-v-466b8079="" src="/img/ams.e29dade1.svg" alt="The Academy of Medical Sciences" class="supporter" style="width: 179.9px;"></a><a data-v-466b8079="" href="//www.alzheimers.org.uk/researchfunding/" aria-label="Alzheimer's Society"><img data-v-466b8079="" src="/img/alzheimerssociety.1d75212b.png" alt="Alzheimer's Society" class="supporter" style="width: 96.6px;"></a><a data-v-466b8079="" href="//www.fwf.ac.at/en/" aria-label="Austrian Science Fund FWF"><img data-v-466b8079="" src="/img/fwf.bf963229.png" alt="Austrian Science Fund FWF" class="supporter" style="width: 156.1px;"></a><a data-v-466b8079="" href="//www.bbsrc.ac.uk/" aria-label="Biotechnology and Biological Sciences Research Council"><img data-v-466b8079="" src="/img/bbsrc.ccee33f5.svg" alt="Biotechnology and Biological Sciences Research Council" class="supporter" style="width: 165.2px;"></a><a data-v-466b8079="" href="//bloodcancer.org.uk/" aria-label="Blood Cancer UK"><img data-v-466b8079="" src="/img/bloodwise.a7a45f9d.png" alt="Blood Cancer UK" class="supporter" style="width: 55.3px;"></a><a data-v-466b8079="" href="//breastcancernow.org" aria-label="Breast Cancer Now"><img data-v-466b8079="" src="/img/bcn.ae2e14c3.svg" alt="Breast Cancer Now" class="supporter" style="width: 110.6px;"></a><a data-v-466b8079="" href="//www.bhf.org.uk/" aria-label="British Heart Foundation"><img data-v-466b8079="" src="/img/bhf.6a4d6caa.svg" alt="British Heart Foundation" class="supporter" style="width: 67.2px;"></a><a data-v-466b8079="" href="//www.cancerresearchuk.org/" aria-label="Cancer Research UK"><img data-v-466b8079="" src="/img/cruk.91f4fd5a.svg" alt="Cancer Research UK" class="supporter" style="width: 150.5px;"></a><a data-v-466b8079="" href="//www.sehd.scot.nhs.uk/cso/" aria-label="Chief Scientist Office"><img data-v-466b8079="" src="/img/cso.078a47ad.svg" alt="Chief Scientist Office" class="supporter" style="width: 146.3px;"></a><a data-v-466b8079="" href="//www.indiaalliance.org/" aria-label="DBT/Wellcome Trust India Alliance"><img data-v-466b8079="" src="/img/indiaalliance.a0af4157.png" alt="DBT/Wellcome Trust India Alliance" class="supporter" style="width: 176.4px;"></a><a data-v-466b8079="" href="//www.diabetes.org.uk/" aria-label="Diabetes UK"><img data-v-466b8079="" src="/img/diabetesuk.7b59ceee.svg" alt="Diabetes UK" class="supporter" style="width: 162.4px;"></a><a data-v-466b8079="" href="//dunhillmedical.org.uk/" aria-label="The Dunhill Medical Trust"><img data-v-466b8079="" src="/img/dunhill.6d2c24ba.svg" alt="The Dunhill Medical Trust" class="supporter" style="width: 178.5px;"></a><a data-v-466b8079="" href="//www.nwo.nl" aria-label="Dutch Research Council (NWO)"><img data-v-466b8079="" src="/img/NWO.2b0b408c.svg" alt="Dutch Research Council (NWO)" class="supporter" style="width: 59.5px;"></a><a data-v-466b8079="" href="//www.edctp.org/" aria-label="European & Developing Countries Clinical Trials Partnership (EDCTP)"><img data-v-466b8079="" src="data:image/png;base64,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" alt="European & Developing Countries Clinical Trials Partnership (EDCTP)" class="supporter" style="width: 70px;"></a><a data-v-466b8079="" href="//erc.europa.eu/" aria-label="European Research Council"><img data-v-466b8079="" src="/img/erc.a7934d32.svg" alt="European Research Council" class="supporter" style="width: 95.2px;"></a><a data-v-466b8079="" href="//healthandcareresearchwales.org/" aria-label="Health and Care Research Wales"><img data-v-466b8079="" src="/img/hcrw.da034d64.png" alt="Health and Care Research Wales" class="supporter" style="width: 196px;"></a><a data-v-466b8079="" href="//www.mariecurie.org.uk/" aria-label="Marie Curie"><img data-v-466b8079="" src="/img/mariecurie.fc18da73.png" alt="Marie Curie" class="supporter" style="width: 77px;"></a><a data-v-466b8079="" href="//www.ukri.org/councils/mrc/" aria-label="Medical Research Council"><img data-v-466b8079="" src="/img/mrc.79b736dd.png" alt="Medical Research Council" class="supporter" style="width: 151.2px;"></a><a data-v-466b8079="" href="//www.medicalresearchfoundation.org.uk/" aria-label="Medical Research Foundation"><img data-v-466b8079="" src="/img/mrf.61eb394c.png" alt="Medical Research Foundation" class="supporter" style="width: 156.1px;"></a><a data-v-466b8079="" href="//www.mndassociation.org/" aria-label="Motor Neurone Disease Association"><img data-v-466b8079="" src="/img/mnda.bda1758c.svg" alt="Motor Neurone Disease Association" class="supporter" style="width: 156.1px;"></a><a data-v-466b8079="" href="//www.mqmentalhealth.org/" aria-label="MQ: Transforming Mental Health"><img data-v-466b8079="" src="/img/mq.cdadb6de.png" alt="MQ: Transforming Mental Health" class="supporter" style="width: 74.9px;"></a><a data-v-466b8079="" href="//www.mssociety.org.uk/" aria-label="Multiple Sclerosis Society"><img data-v-466b8079="" src="/img/mssociety.207dfe6a.svg" alt="Multiple Sclerosis Society" class="supporter" style="width: 110.6px;"></a><a data-v-466b8079="" href="//www.nc3rs.org.uk" aria-label="National Centre for the Replacement, Refinement and Reduction of Animals in Research"><img data-v-466b8079="" src="/img/nc3rs.0e0f352d.svg" alt="National Centre for the Replacement, Refinement and Reduction of Animals in Research" class="supporter" style="width: 150.5px;"></a><a data-v-466b8079="" href="//www.nihr.ac.uk/" aria-label="National Institute for Health Research (NIHR)"><img data-v-466b8079="" src="/img/nihr.13ce020c.svg" alt="National Institute for Health Research (NIHR)" class="supporter" style="width: 182px;"></a><a data-v-466b8079="" href="//www.pancreaticcancer.org.uk/" aria-label="Pancreatic Cancer UK"><img data-v-466b8079="" src="/img/pancreaticuk.de4e0ce6.svg" alt="Pancreatic Cancer UK" class="supporter" style="width: 105px;"></a><a data-v-466b8079="" href="//www.parkinsons.org.uk/" aria-label="Parkinson's UK"><img data-v-466b8079="" src="/img/puk.f8d0ec15.svg" alt="Parkinson's UK" class="supporter" style="width: 148.4px;"></a><a data-v-466b8079="" href="//rnid.org.uk/" aria-label="RNID"><img data-v-466b8079="" src="/img/rnid.11b047b5.svg" alt="RNID" class="supporter" style="width: 57.4px;"></a><a data-v-466b8079="" href="//www.snf.ch/en/Pages/default.aspx" aria-label="Swiss National Science Foundation"><img data-v-466b8079="" src="/img/snsf.d3f29016.svg" alt="Swiss National Science Foundation" class="supporter" style="width: 184.8px;"></a><a data-v-466b8079="" href="//www.telethon.it/en" aria-label="Telethon Italy"><img data-v-466b8079="" src="/img/ti.1fed58a8.svg" alt="Telethon Italy" class="supporter" style="width: 112px;"></a><a data-v-466b8079="" href="//www.versusarthritis.org/" aria-label="Versus Arthritis"><img data-v-466b8079="" src="/img/versusarthritis.c0412708.svg" alt="Versus Arthritis" class="supporter" style="width: 108.5px;"></a><a data-v-466b8079="" href="//www.wellcome.ac.uk/" aria-label="Wellcome Trust"><img data-v-466b8079="" src="/img/wellcome.ab2535ee.svg" alt="Wellcome Trust" class="supporter" style="width: 70px;"></a><a data-v-466b8079="" href="//www.who.int/" aria-label="World Health Organization"><img data-v-466b8079="" src="/img/who.734e840b.svg" alt="World Health Organization" class="supporter" style="width: 147px;"></a><a data-v-466b8079="" href="//www.worldwidecancerresearch.org/" aria-label="Worldwide Cancer Research"><img data-v-466b8079="" src="/img/wcr.437038c0.svg" alt="Worldwide Cancer Research" class="supporter" style="width: 113.4px;"></a><a data-v-466b8079="" href="//yorkshirecancerresearch.org.uk/" aria-label="Yorkshire Cancer Research"><img data-v-466b8079="" src="/img/ycr.e2d70e5a.svg" alt="Yorkshire Cancer Research" class="supporter" style="width: 135.8px;"></a><a data-v-466b8079="" href="//www.zonmw.nl/en" aria-label="ZonMw"><img data-v-466b8079="" src="/img/ZonMw.0a506489.png" alt="ZonMw" class="supporter" style="width: 135.8px;"></a><a data-v-466b8079="" href="//www.embl.org/" aria-label="EMBL"><img data-v-466b8079="" src="/img/embl.335061e5.png" alt="EMBL" class="supporter" style="width: 126px;"></a></div></div></div></div></div><div data-v-9b7d8ffa="" id="footer"><div data-v-9b7d8ffa="" id="follow-us-section"><p class="h2">Follow us</p><div id="follow-us-icons"><a href="http://blog.europepmc.org/" class="action"><i class="fas fa-blog feature-large"></i><br>News blog </a><a href="//europepmc.github.io/techblog/" class="action"><i class="fas fa-cogs feature-large"></i><br>Technical blog </a><a href="//twitter.com/EuropePMC_news" class="action"><i class="fab fa-x-twitter feature-large"></i><br>Twitter </a><a href="//www.youtube.com/user/EuropePMC" class="action"><i class="fab fa-youtube feature-large"></i><br>YouTube </a></div></div><div data-v-9b7d8ffa="" id="footer-bottom"><div data-v-9b7d8ffa="" class="partnership-and-funding container"><h2 data-v-9b7d8ffa="">Partnerships & funding</h2><p data-v-9b7d8ffa=""> Europe PMC is developed by <a data-v-9b7d8ffa="" href="https://www.ebi.ac.uk/">EMBL-EBI</a> with support from the <a 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data-v-9b7d8ffa=""> Europe PMC is an <a data-v-9b7d8ffa="" href="https://elixir-europe.org/platforms/data/core-data-resources"> ELIXIR Core Data Resource</a>, <a data-v-9b7d8ffa="" href="https://globalbiodata.org/what-we-do/global-core-biodata-resources/"> Global Core Biodata Resource</a>, and conforms with <a data-v-9b7d8ffa="" href="https://www.ebi.ac.uk/long-term-data-preservation"> EMBL-EBI鈥檚 long term data preservation policies</a>. </p></div></div></div></div><script> /*<![CDATA[*/ //survey changes function showSurvey(){ $(window).scroll(function(){ if (!navigator.cookieEnabled) { console.log("Cookie not enabled."); return; } if ($.cookie('no_impact_survey_session')) { console.log("no_impact_survey_session set."); return; } if ($.cookie('no_impact_survey_app')) { console.log("no_impact_survey_app set."); return; } $("div#europepmc_impact_survey").show(); }); } function hideSurvey() { $("div#europepmc_impact_survey").hide(); $('#ask-me-later-container').hide(); } function 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