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Title</option><option value="a-author">A-Z By Author</option><option value="z-author">Z-A By Author</option><option value="asc">Date Ascending</option><option value="desc">Date Descending</option></select></div><div class="o-input__droplist1 c-sort__page-input"><label for="c-sort2">Show:</label><select name="rows" id="c-sort2" form="facetForm"><option selected="" value="10">10</option><option value="20">20</option><option value="30">30</option></select></div></div><input type="hidden" name="start" form="facetForm" value="0"/><nav class="c-pagination"><ul><li><a href="" aria-label="you are on result set 1" class="c-pagination__item--current">1</a></li><li><a href="" aria-label="go to result set 2" class="c-pagination__item">2</a></li><li><a href="" aria-label="go to result set 3" class="c-pagination__item">3</a></li></ul></nav></div><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/41d8x6np"><div class="c-clientmarkup">Is the Problem with Antitrust Law or Antitrust Enforcement?</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3ADay%2C%20Gregory">Day, Gregory</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/lawandpoliticaleconomy/5/1">Journal of Law and Political Economy, Volume 5, Issue 1</a> (2025)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup"><p>There is an emerging belief that antitrust has failed marginalized populations. For example, exclusionary practices have helped to produce banking and food deserts in low-income communities, though antitrust has seldom intervened. But is this a problem of antitrust law? In fact, another claim is that antitrust <em>law </em>is just fine as opposed to how federal agencies <em>enforce </em>antitrust. Since agencies must decide which cases to bring, they should perhaps pay better attention to marginalized communities or draft complaints to emphasize their unique injuries. This topic is especially salient, given the ongoing debate about whether the consumer welfare standard is able to promote competition in modern markets. In essence, the root of why antitrust has yet to meet its potential of serving marginalized communities may lie with the law and its interpretation or, alternatively, people and organizations enforcing it.</p></div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/41d8x6np"><img src="/cms-assets/26215630ec557377854da79bd3d81c24888977304abc35d87907d62a4a52f2ad" alt="Cover page: Is the Problem with Antitrust Law or Antitrust Enforcement?"/></a><a href="https://creativecommons.org/licenses/by-nc-sa/4.0/" class="c-scholworks__license"><img class="c-lazyimage" data-src="/images/cc-by-nc-sa-small.svg" alt="Creative Commons 'BY-NC-SA' version 4.0 license"/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/4zw9341d"><div class="c-clientmarkup">Consensus recommendations for clinical assessment tools for the diagnosis of posterior cortical atrophy syndrome from the Atypical AD PIA of ISTAART</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3APelak%2C%20Victoria%20S">Pelak, Victoria S</a>; </li><li><a href="/search/?q=author%3ATang%E2%80%90Wai%2C%20David%20F">Tang‐Wai, David F</a>; </li><li><a href="/search/?q=author%3ABoeve%2C%20Bradley%20F">Boeve, Bradley F</a>; </li><li><a href="/search/?q=author%3ABouwman%2C%20Femke%20H">Bouwman, Femke H</a>; </li><li><a href="/search/?q=author%3AGraff%E2%80%90Radford%2C%20Jonathan">Graff‐Radford, Jonathan</a>; </li><li><a href="/search/?q=author%3ARabinovici%2C%20Gil">Rabinovici, Gil</a>; </li><li><a href="/search/?q=author%3AHolden%2C%20Samantha%20K">Holden, Samantha K</a>; </li><li><a href="/search/?q=author%3ATownley%2C%20Ryan%20A">Townley, Ryan A</a>; </li><li><a href="/search/?q=author%3ADay%2C%20Gregory%20S">Day, Gregory S</a>; </li><li><a href="/search/?q=author%3AWhitwell%2C%20Jennifer">Whitwell, Jennifer</a>; </li><li><a href="/search/?q=author%3AOssenkoppele%2C%20Rik">Ossenkoppele, Rik</a>; </li><li><a href="/search/?q=author%3ABoon%2C%20Baayla%20DC">Boon, Baayla DC</a>; </li><li><a href="/search/?q=author%3APutcha%2C%20Deepti">Putcha, Deepti</a>; </li><li><a href="/search/?q=author%3AOnyike%2C%20Chiadi%20U">Onyike, Chiadi U</a>; </li><li><a href="/search/?q=author%3ASnyder%2C%20Heather">Snyder, Heather</a>; </li><li><a href="/search/?q=author%3ACrutch%2C%20Sebastian">Crutch, Sebastian</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AYong%2C%20Keir%20XX">Yong, Keir XX</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucsf_postprints">UC San Francisco Previously Published Works</a> (2023)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup"><h3>Introduction</h3>Delay in diagnosis of posterior cortical atrophy (PCA) syndrome is common, and the lack of familiarity with assessment tools for identifying visual cortical dysfunction is a contributing factor. We propose recommendations for the approach to the evaluation of PCA clinical features during the office visit, the neuropsychological evaluation, and the research setting. A recommended screening battery for eye clinics is also proposed.<h3>Methods</h3>Recommendations were developed using results from a web-based survey of members of Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) Atypical Alzheimer's Disease Professional Interest Area (PIA), literature review, and consensus by the PCA assessment working party of the Atypical Alzheimer's Disease PIA.<h3>Results</h3>Survey results revealed robust agreement for assessment tool preferences for PCA features, and many respondents indicated that they reserve assessment tools for use only when PCA is suspected. For some PCA features, curated tools were preferred over validated battery tools, particularly for the office visit. Consensus recommendations superseded survey preferences for two core cognitive features within the 2017 PCA diagnostic criteria.<h3>Discussion</h3>These consensus recommendations provide an evaluation framework for PCA clinical features and can facilitate timely and accurate recognition and diagnosis of PCA. Broader use of these tools should be sought, and development and validation of novel PCA clinical outcome assessments are needed to improve our understanding of atypical AD and other dementias and support the inclusion of those with PCA in treatment trials.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/4zw9341d"><img src="/cms-assets/d0c37785e5f830475ebd41a7cc4cb7b4a0612eb6a5db3590ab897709d3274394" alt="Cover page: Consensus recommendations for clinical assessment tools for the diagnosis of posterior cortical atrophy syndrome from the Atypical AD PIA of ISTAART"/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/5z97w1k2"><div class="c-clientmarkup">CSF tau microtubule-binding region identifies pathological changes in primary tauopathies</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3AHorie%2C%20Kanta">Horie, Kanta</a>; </li><li><a href="/search/?q=author%3ABarth%C3%A9lemy%2C%20Nicolas%20R">Barthélemy, Nicolas R</a>; </li><li><a href="/search/?q=author%3ASpina%2C%20Salvatore">Spina, Salvatore</a>; </li><li><a href="/search/?q=author%3AVandeVrede%2C%20Lawren">VandeVrede, Lawren</a>; </li><li><a href="/search/?q=author%3AHe%2C%20Yingxin">He, Yingxin</a>; </li><li><a href="/search/?q=author%3APaterson%2C%20Ross%20W">Paterson, Ross W</a>; </li><li><a href="/search/?q=author%3AWright%2C%20Brenton%20A">Wright, Brenton A</a>; </li><li><a href="/search/?q=author%3ADay%2C%20Gregory%20S">Day, Gregory S</a>; </li><li><a href="/search/?q=author%3ADavis%2C%20Albert%20A">Davis, Albert A</a>; </li><li><a href="/search/?q=author%3AKarch%2C%20Celeste%20M">Karch, Celeste M</a>; </li><li><a href="/search/?q=author%3ASeeley%2C%20William%20W">Seeley, William W</a>; </li><li><a href="/search/?q=author%3APerrin%2C%20Richard%20J">Perrin, Richard J</a>; </li><li><a href="/search/?q=author%3AKoppisetti%2C%20Rama%20K">Koppisetti, Rama K</a>; </li><li><a href="/search/?q=author%3AShaikh%2C%20Faris">Shaikh, Faris</a>; </li><li><a href="/search/?q=author%3ALago%2C%20Argentina%20Lario">Lago, Argentina Lario</a>; </li><li><a href="/search/?q=author%3AHeuer%2C%20Hilary%20W">Heuer, Hilary W</a>; </li><li><a href="/search/?q=author%3AGhoshal%2C%20Nupur">Ghoshal, Nupur</a>; </li><li><a href="/search/?q=author%3AGabelle%2C%20Audrey">Gabelle, Audrey</a>; </li><li><a href="/search/?q=author%3AMiller%2C%20Bruce%20L">Miller, Bruce L</a>; </li><li><a href="/search/?q=author%3ABoxer%2C%20Adam%20L">Boxer, Adam L</a>; </li><li><a href="/search/?q=author%3ABateman%2C%20Randall%20J">Bateman, Randall J</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3ASato%2C%20Chihiro">Sato, Chihiro</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucsf_postprints">UC San Francisco Previously Published Works</a> (2022)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup">Despite recent advances in fluid biomarker research in Alzheimer's disease (AD), there are no fluid biomarkers or imaging tracers with utility for diagnosis and/or theragnosis available for other tauopathies. Using immunoprecipitation and mass spectrometry, we show that 4 repeat (4R) isoform-specific tau species from microtubule-binding region (MTBR-tau<sub>275</sub> and MTBR-tau<sub>282</sub>) increase in the brains of corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), frontotemporal lobar degeneration (FTLD)-MAPT and AD but decrease inversely in the cerebrospinal fluid (CSF) of CBD, FTLD-MAPT and AD compared to control and other FTLD-tau (for example, Pick's disease). CSF MTBR-tau measures are reproducible in repeated lumbar punctures and can be used to distinguish CBD from control (receiver operating characteristic area under the curve (AUC) = 0.889) and other FTLD-tau, such as PSP (AUC = 0.886). CSF MTBR-tau<sub>275</sub> and MTBR-tau<sub>282</sub> may represent the first affirmative biomarkers to aid in the diagnosis of primary tauopathies and facilitate clinical trial designs.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/5z97w1k2"><img src="/cms-assets/612455fa740dc5b296787549527c5125f594edb21bfb69150a6a5818abc06d50" alt="Cover page: CSF tau microtubule-binding region identifies pathological changes in primary tauopathies"/></a><a href="https://creativecommons.org/licenses/by/4.0/" class="c-scholworks__license"><img class="c-lazyimage" data-src="/images/cc-by-small.svg" alt="Creative Commons 'BY' version 4.0 license"/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/278276xt"><div class="c-clientmarkup">A scalable solid-state nanoporous network with atomic-level interaction design for carbon dioxide capture</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3AMao%2C%20Haiyan">Mao, Haiyan</a>; </li><li><a href="/search/?q=author%3ATang%2C%20Jing">Tang, Jing</a>; </li><li><a href="/search/?q=author%3ADay%2C%20Gregory%20S">Day, Gregory S</a>; </li><li><a href="/search/?q=author%3APeng%2C%20Yucan">Peng, Yucan</a>; </li><li><a href="/search/?q=author%3AWang%2C%20Haoze">Wang, Haoze</a>; </li><li><a href="/search/?q=author%3AXiao%2C%20Xin">Xiao, Xin</a>; </li><li><a href="/search/?q=author%3AYang%2C%20Yufei">Yang, Yufei</a>; </li><li><a href="/search/?q=author%3AJiang%2C%20Yuanwen">Jiang, Yuanwen</a>; </li><li><a href="/search/?q=author%3AChen%2C%20Shuo">Chen, Shuo</a>; </li><li><a href="/search/?q=author%3AHalat%2C%20David%20M">Halat, David M</a>; </li><li><a href="/search/?q=author%3ALund%2C%20Alicia">Lund, Alicia</a>; </li><li><a href="/search/?q=author%3ALv%2C%20Xudong">Lv, Xudong</a>; </li><li><a href="/search/?q=author%3AZhang%2C%20Wenbo">Zhang, Wenbo</a>; </li><li><a href="/search/?q=author%3AYang%2C%20Chongqing">Yang, Chongqing</a>; </li><li><a href="/search/?q=author%3ALin%2C%20Zhou">Lin, Zhou</a>; </li><li><a href="/search/?q=author%3AZhou%2C%20Hong-Cai">Zhou, Hong-Cai</a>; </li><li><a href="/search/?q=author%3APines%2C%20Alexander">Pines, Alexander</a>; </li><li><a href="/search/?q=author%3ACui%2C%20Yi">Cui, Yi</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AReimer%2C%20Jeffrey%20A">Reimer, Jeffrey A</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucb_postprints">UC Berkeley Previously Published Works</a> (2022)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup">Carbon capture and sequestration reduces carbon dioxide emissions and is critical in accomplishing carbon neutrality targets. Here, we demonstrate new sustainable, solid-state, polyamine-appended, cyanuric acid-stabilized melamine nanoporous networks (MNNs) via dynamic combinatorial chemistry (DCC) at the kilogram scale toward effective and high-capacity carbon dioxide capture. Polyamine-appended MNNs reaction mechanisms with carbon dioxide were elucidated with double-level DCC where two-dimensional heteronuclear chemical shift correlation nuclear magnetic resonance spectroscopy was performed to demonstrate the interatomic interactions. We distinguished ammonium carbamate pairs and a mix of ammonium carbamate and carbamic acid during carbon dioxide chemisorption. The coordination of polyamine and cyanuric acid modification endows MNNs with high adsorption capacity (1.82 millimoles per gram at 1 bar), fast adsorption time (less than 1 minute), low price, and extraordinary stability to cycling by flue gas. This work creates a general industrialization method toward carbon dioxide capture via DCC atomic-level design strategies.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/278276xt"><img src="/cms-assets/5177a666839a89d174bbe6c0cbf97682066a8c8d926f34dc2f66ef770c10314d" alt="Cover page: A scalable solid-state nanoporous network with atomic-level interaction design for carbon dioxide capture"/></a><a href="https://creativecommons.org/licenses/by-nc/4.0/" class="c-scholworks__license"><img class="c-lazyimage" data-src="/images/cc-by-nc-small.svg" alt="Creative Commons 'BY-NC' version 4.0 license"/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/3kw5r9zc"><div class="c-clientmarkup">Differences in baseline cognitive performance between participants with early-onset and late-onset Alzheimers disease: Comparison of LEADS and ADNI.</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3AHammers%2C%20Dustin">Hammers, Dustin</a>; </li><li><a href="/search/?q=author%3AEloyan%2C%20Ani">Eloyan, Ani</a>; </li><li><a href="/search/?q=author%3AThangarajah%2C%20Maryanne">Thangarajah, Maryanne</a>; </li><li><a href="/search/?q=author%3ATaurone%2C%20Alexander">Taurone, Alexander</a>; </li><li><a href="/search/?q=author%3ABeckett%2C%20Laurel">Beckett, Laurel</a>; </li><li><a href="/search/?q=author%3AGao%2C%20Sujuan">Gao, Sujuan</a>; </li><li><a href="/search/?q=author%3APolsinelli%2C%20Angelina">Polsinelli, Angelina</a>; </li><li><a href="/search/?q=author%3AKirby%2C%20Kala">Kirby, Kala</a>; </li><li><a href="/search/?q=author%3ADage%2C%20Jeffrey">Dage, Jeffrey</a>; </li><li><a href="/search/?q=author%3ANudelman%2C%20Kelly">Nudelman, Kelly</a>; </li><li><a href="/search/?q=author%3AAisen%2C%20Paul">Aisen, Paul</a>; </li><li><a href="/search/?q=author%3AReman%2C%20Rema">Reman, Rema</a>; </li><li><a href="/search/?q=author%3ALa%20Joie%2C%20Renaud">La Joie, Renaud</a>; </li><li><a href="/search/?q=author%3ALagarde%2C%20Julien">Lagarde, Julien</a>; </li><li><a href="/search/?q=author%3AAtri%2C%20Alireza">Atri, Alireza</a>; </li><li><a href="/search/?q=author%3AClark%2C%20David">Clark, David</a>; </li><li><a href="/search/?q=author%3ADay%2C%20Gregory">Day, Gregory</a>; </li><li><a href="/search/?q=author%3ADuara%2C%20Ranjan">Duara, Ranjan</a>; </li><li><a href="/search/?q=author%3AGraff-Radford%2C%20Neill">Graff-Radford, Neill</a>; </li><li><a href="/search/?q=author%3AHonig%2C%20Lawrence">Honig, Lawrence</a>; </li><li><a href="/search/?q=author%3AJones%2C%20David">Jones, David</a>; </li><li><a href="/search/?q=author%3AMasdeu%2C%20Joseph">Masdeu, Joseph</a>; </li><li><a href="/search/?q=author%3AMendez%2C%20Mario">Mendez, Mario</a>; </li><li><a href="/search/?q=author%3AWomack%2C%20Kyle">Womack, Kyle</a>; </li><li><a href="/search/?q=author%3AMusiek%2C%20Erik">Musiek, Erik</a>; </li><li><a href="/search/?q=author%3AOnyike%2C%20Chiadi">Onyike, Chiadi</a>; </li><li><a href="/search/?q=author%3ARiddle%2C%20Meghan">Riddle, Meghan</a>; </li><li><a href="/search/?q=author%3AGrant%2C%20Ian">Grant, Ian</a>; </li><li><a href="/search/?q=author%3ARogalski%2C%20Emily">Rogalski, Emily</a>; </li><li><a href="/search/?q=author%3AJohnson%2C%20Erik">Johnson, Erik</a>; </li><li><a href="/search/?q=author%3ASalloway%2C%20Steven">Salloway, Steven</a>; </li><li><a href="/search/?q=author%3ASha%2C%20Sharon">Sha, Sharon</a>; </li><li><a href="/search/?q=author%3ATurner%2C%20Raymond">Turner, Raymond</a>; </li><li><a href="/search/?q=author%3AWingo%2C%20Thomas">Wingo, Thomas</a>; </li><li><a href="/search/?q=author%3AWolk%2C%20David">Wolk, David</a>; </li><li><a href="/search/?q=author%3ACarrillo%2C%20Maria">Carrillo, Maria</a>; </li><li><a href="/search/?q=author%3ADickerson%2C%20Bradford">Dickerson, Bradford</a>; </li><li><a href="/search/?q=author%3ARabinovici%2C%20Gil">Rabinovici, Gil</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AApostolova%2C%20Liana">Apostolova, Liana</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucsf_postprints">UC San Francisco Previously Published Works</a> (2025)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup">INTRODUCTION: Early-onset Alzheimers disease (EOAD) and late-onset Alzheimers disease (LOAD) share similar amyloid etiology, but evidence from smaller-scale studies suggests that they manifest differently clinically. Current analyses sought to contrast the cognitive profiles of EOAD and LOAD. METHODS: Z-score cognitive-domain composites for 311 amyloid-positive sporadic EOAD and 314 amyloid-positive LOAD participants were calculated from baseline data from age-appropriate control cohorts. Z-score composites were compared between AD groups for each domain. RESULTS: After controlling for cognitive status, EOAD displayed worse visuospatial, executive functioning, and processing speed/attention skills relative to LOAD, and LOAD displayed worse language, episodic immediate memory, and episodic delayed memory. DISCUSSION: Sporadic EOAD possesses distinct cognitive profiles relative to LOAD. Clinicians should be alert for non-amnestic impairments in younger patients to ensure proper identification and intervention using disease-modifying treatments. HIGHLIGHTS: Both early-onset Alzheimers disease (EOAD) and late-onset Alzheimers disease (LOAD) participants displayed widespread cognitive impairments relative to their same-aged peers. Cognitive impairments were more severe for EOAD than for LOAD participants in visuospatial and executive domains. Memory and language impairments were more severe for LOAD than for EOAD participants Results were comparable after removing clinical phenotypes of posterior cortical atrophy (PCA), primary progressive aphasia (lv-PPA), and frontal-variant AD.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/3kw5r9zc"><img src="/cms-assets/da879d394a23e1630d99c888e3beebba698ca1e1445e73c1cb4bcd3f614e4504" alt="Cover page: Differences in baseline cognitive performance between participants with early-onset and late-onset Alzheimers disease: Comparison of LEADS and ADNI."/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/7vv471hp"><div class="c-clientmarkup">Longitudinal clinical, cognitive and biomarker profiles in dominantly inherited versus sporadic early-onset Alzheimer’s disease</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3ALlibre-Guerra%2C%20Jorge%20J">Llibre-Guerra, Jorge J</a>; </li><li><a href="/search/?q=author%3AIaccarino%2C%20Leonardo">Iaccarino, Leonardo</a>; </li><li><a href="/search/?q=author%3ACoble%2C%20Dean">Coble, Dean</a>; </li><li><a href="/search/?q=author%3AEdwards%2C%20Lauren">Edwards, Lauren</a>; </li><li><a href="/search/?q=author%3ALi%2C%20Yan">Li, Yan</a>; </li><li><a href="/search/?q=author%3AMcDade%2C%20Eric">McDade, Eric</a>; </li><li><a href="/search/?q=author%3AStrom%2C%20Amelia">Strom, Amelia</a>; </li><li><a href="/search/?q=author%3AGordon%2C%20Brian">Gordon, Brian</a>; </li><li><a href="/search/?q=author%3AMundada%2C%20Nidhi">Mundada, Nidhi</a>; </li><li><a href="/search/?q=author%3ASchindler%2C%20Suzanne%20E">Schindler, Suzanne E</a>; </li><li><a href="/search/?q=author%3ATsoy%2C%20Elena">Tsoy, Elena</a>; </li><li><a href="/search/?q=author%3AMa%2C%20Yinjiao">Ma, Yinjiao</a>; </li><li><a href="/search/?q=author%3ALu%2C%20Ruijin">Lu, Ruijin</a>; </li><li><a href="/search/?q=author%3AFagan%2C%20Anne%20M">Fagan, Anne M</a>; </li><li><a href="/search/?q=author%3ABenzinger%2C%20Tammie%20LS">Benzinger, Tammie LS</a>; </li><li><a href="/search/?q=author%3ASoleimani-Meigooni%2C%20David">Soleimani-Meigooni, David</a>; </li><li><a href="/search/?q=author%3AAschenbrenner%2C%20Andrew%20J">Aschenbrenner, Andrew J</a>; </li><li><a href="/search/?q=author%3AMiller%2C%20Zachary">Miller, Zachary</a>; </li><li><a href="/search/?q=author%3AWang%2C%20Guoqiao">Wang, Guoqiao</a>; </li><li><a href="/search/?q=author%3AKramer%2C%20Joel%20H">Kramer, Joel H</a>; </li><li><a href="/search/?q=author%3AHassenstab%2C%20Jason">Hassenstab, Jason</a>; </li><li><a href="/search/?q=author%3ARosen%2C%20Howard%20J">Rosen, Howard J</a>; </li><li><a href="/search/?q=author%3AMorris%2C%20John%20C">Morris, John C</a>; </li><li><a href="/search/?q=author%3AMiller%2C%20Bruce%20L">Miller, Bruce L</a>; </li><li><a href="/search/?q=author%3AXiong%2C%20Chengjie">Xiong, Chengjie</a>; </li><li><a href="/search/?q=author%3APerrin%2C%20Richard%20J">Perrin, Richard J</a>; </li><li><a href="/search/?q=author%3AAllegri%2C%20Ricardo">Allegri, Ricardo</a>; </li><li><a href="/search/?q=author%3AChrem%2C%20Patricio">Chrem, Patricio</a>; </li><li><a href="/search/?q=author%3ASurace%2C%20Ezequiel">Surace, Ezequiel</a>; </li><li><a href="/search/?q=author%3ABerman%2C%20Sarah%20B">Berman, Sarah B</a>; </li><li><a href="/search/?q=author%3AChhatwal%2C%20Jasmeer">Chhatwal, Jasmeer</a>; </li><li><a href="/search/?q=author%3AMasters%2C%20Colin%20L">Masters, Colin L</a>; </li><li><a href="/search/?q=author%3AFarlow%2C%20Martin%20R">Farlow, Martin R</a>; </li><li><a href="/search/?q=author%3AJucker%2C%20Mathias">Jucker, Mathias</a>; </li><li><a href="/search/?q=author%3ALevin%2C%20Johannes">Levin, Johannes</a>; </li><li><a href="/search/?q=author%3AFox%2C%20Nick%20C">Fox, Nick C</a>; </li><li><a href="/search/?q=author%3ADay%2C%20Gregory">Day, Gregory</a>; </li><li><a href="/search/?q=author%3AGorno-Tempini%2C%20Maria%20Luisa">Gorno-Tempini, Maria Luisa</a>; </li><li><a href="/search/?q=author%3ABoxer%2C%20Adam%20L">Boxer, Adam L</a>; </li><li><a href="/search/?q=author%3ALa%20Joie%2C%20Renaud">La Joie, Renaud</a>; </li><li><a href="/search/?q=author%3ARabinovici%2C%20Gil%20D">Rabinovici, Gil D</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3ABateman%2C%20Randall">Bateman, Randall</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucsf_postprints">UC San Francisco Previously Published Works</a> (2023)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup">Approximately 5% of Alzheimer's disease cases have an early age at onset (<65 years), with 5-10% of these cases attributed to dominantly inherited mutations and the remainder considered as sporadic. The extent to which dominantly inherited and sporadic early-onset Alzheimer's disease overlap is unknown. In this study, we explored the clinical, cognitive and biomarker profiles of early-onset Alzheimer's disease, focusing on commonalities and distinctions between dominantly inherited and sporadic cases. Our analysis included 117 participants with dominantly inherited Alzheimer's disease enrolled in the Dominantly Inherited Alzheimer Network and 118 individuals with sporadic early-onset Alzheimer's disease enrolled at the University of California San Francisco Alzheimer's Disease Research Center. Baseline differences in clinical and biomarker profiles between both groups were compared using <i>t</i>-tests. Differences in the rates of decline were compared using linear mixed-effects models. Individuals with dominantly inherited Alzheimer's disease exhibited an earlier age-at-symptom onset compared with the sporadic group [43.4 (SD ± 8.5) years versus 54.8 (SD ± 5.0) years, respectively, <i>P</i> < 0.001]. Sporadic cases showed a higher frequency of atypical clinical presentations relative to dominantly inherited (56.8% versus 8.5%, respectively) and a higher frequency of APOE-ε4 (50.0% versus 28.2%, <i>P</i> = 0.001). Compared with sporadic early onset, motor manifestations were higher in the dominantly inherited cohort [32.5% versus 16.9% at baseline (<i>P</i> = 0.006) and 46.1% versus 25.4% at last visit (<i>P</i> = 0.001)]. At baseline, the sporadic early-onset group performed worse on category fluency (<i>P</i> < 0.001), Trail Making Test Part B (<i>P</i> < 0.001) and digit span (<i>P</i> < 0.001). Longitudinally, both groups demonstrated similar rates of cognitive and functional decline in the early stages. After 10 years from symptom onset, dominantly inherited participants experienced a greater decline as measured by Clinical Dementia Rating Sum of Boxes [3.63 versus 1.82 points (<i>P</i> = 0.035)]. CSF amyloid beta-42 levels were comparable [244 (SD ± 39.3) pg/ml dominantly inherited versus 296 (SD ± 24.8) pg/ml sporadic early onset, <i>P</i> = 0.06]. CSF phosphorylated tau at threonine 181 levels were higher in the dominantly inherited Alzheimer's disease cohort (87.3 versus 59.7 pg/ml, <i>P</i> = 0.005), but no significant differences were found for t-tau levels (<i>P</i> = 0.35). In summary, sporadic and inherited Alzheimer's disease differed in baseline profiles; sporadic early onset is best distinguished from dominantly inherited by later age at onset, high frequency of atypical clinical presentations and worse executive performance at baseline. Despite these differences, shared pathways in longitudinal clinical decline and CSF biomarkers suggest potential common therapeutic targets for both populations, offering valuable insights for future research and clinical trial design.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/7vv471hp"><img src="/cms-assets/06f7c8952a10fece9b2df32896d5563c33881ed8bf2089474f09bc72ec597d94" alt="Cover page: Longitudinal clinical, cognitive and biomarker profiles in dominantly inherited versus sporadic early-onset Alzheimer’s disease"/></a><a href="https://creativecommons.org/licenses/by/4.0/" class="c-scholworks__license"><img class="c-lazyimage" data-src="/images/cc-by-small.svg" alt="Creative Commons 'BY' version 4.0 license"/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/7kd5r07k"><div class="c-clientmarkup">Pathogenic variants in the Longitudinal Early‐onset Alzheimer's Disease Study cohort</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3ANudelman%2C%20Kelly%20NH">Nudelman, Kelly NH</a>; </li><li><a href="/search/?q=author%3AJackson%2C%20Trever">Jackson, Trever</a>; </li><li><a href="/search/?q=author%3ARumbaugh%2C%20Malia">Rumbaugh, Malia</a>; </li><li><a href="/search/?q=author%3AEloyan%2C%20Ani">Eloyan, Ani</a>; </li><li><a href="/search/?q=author%3AAbreu%2C%20Marco">Abreu, Marco</a>; </li><li><a href="/search/?q=author%3ADage%2C%20Jeffrey%20L">Dage, Jeffrey L</a>; </li><li><a href="/search/?q=author%3ASnoddy%2C%20Casey">Snoddy, Casey</a>; </li><li><a href="/search/?q=author%3AFaber%2C%20Kelley%20M">Faber, Kelley M</a>; </li><li><a href="/search/?q=author%3AForoud%2C%20Tatiana">Foroud, Tatiana</a>; </li><li><a href="/search/?q=author%3AHammers%2C%20Dustin%20B">Hammers, Dustin B</a>; </li><li><a href="/search/?q=author%3ACommittee%2C%20DIAN%20DIAN%E2%80%90TU%20Clinical%20Genetics">Committee, DIAN DIAN‐TU Clinical Genetics</a>; </li><li><a href="/search/?q=author%3ATaurone%2C%20Alexander">Taurone, Alexander</a>; </li><li><a href="/search/?q=author%3AThangarajah%2C%20Maryanne">Thangarajah, Maryanne</a>; </li><li><a href="/search/?q=author%3AAisen%2C%20Paul">Aisen, Paul</a>; </li><li><a href="/search/?q=author%3ABeckett%2C%20Laurel">Beckett, Laurel</a>; </li><li><a href="/search/?q=author%3AKramer%2C%20Joel">Kramer, Joel</a>; </li><li><a href="/search/?q=author%3AKoeppe%2C%20Robert">Koeppe, Robert</a>; </li><li><a href="/search/?q=author%3AKukull%2C%20Walter%20A">Kukull, Walter A</a>; </li><li><a href="/search/?q=author%3AMurray%2C%20Melissa%20E">Murray, Melissa E</a>; </li><li><a href="/search/?q=author%3AToga%2C%20Arthur%20W">Toga, Arthur W</a>; </li><li><a href="/search/?q=author%3AVemuri%2C%20Prashanthi">Vemuri, Prashanthi</a>; </li><li><a href="/search/?q=author%3AAtri%2C%20Alireza">Atri, Alireza</a>; </li><li><a href="/search/?q=author%3ADay%2C%20Gregory%20S">Day, Gregory S</a>; </li><li><a href="/search/?q=author%3ADuara%2C%20Ranjan">Duara, Ranjan</a>; </li><li><a href="/search/?q=author%3AGraff%E2%80%90Radford%2C%20Neill%20R">Graff‐Radford, Neill R</a>; </li><li><a href="/search/?q=author%3AHonig%2C%20Lawrence%20S">Honig, Lawrence S</a>; </li><li><a href="/search/?q=author%3AJones%2C%20David%20T">Jones, David T</a>; </li><li><a href="/search/?q=author%3AMasdeu%2C%20Joseph%20C">Masdeu, Joseph C</a>; </li><li><a href="/search/?q=author%3AMendez%2C%20Mario">Mendez, Mario</a>; </li><li><a href="/search/?q=author%3AMusiek%2C%20Erik">Musiek, Erik</a>; </li><li><a href="/search/?q=author%3AOnyike%2C%20Chiadi%20U">Onyike, Chiadi U</a>; </li><li><a href="/search/?q=author%3ARiddle%2C%20Meghan">Riddle, Meghan</a>; </li><li><a href="/search/?q=author%3ARogalski%2C%20Emily">Rogalski, Emily</a>; </li><li><a href="/search/?q=author%3ASalloway%2C%20Stephen">Salloway, Stephen</a>; </li><li><a href="/search/?q=author%3ASha%2C%20Sharon%20J">Sha, Sharon J</a>; </li><li><a href="/search/?q=author%3ATurner%2C%20R%20Scott">Turner, R Scott</a>; </li><li><a href="/search/?q=author%3AWingo%2C%20Thomas%20S">Wingo, Thomas S</a>; </li><li><a href="/search/?q=author%3AWolk%2C%20David%20A">Wolk, David A</a>; </li><li><a href="/search/?q=author%3ACarrillo%2C%20Maria%20C">Carrillo, Maria C</a>; </li><li><a href="/search/?q=author%3ADickerson%2C%20Bradford%20C">Dickerson, Bradford C</a>; </li><li><a href="/search/?q=author%3ARabinovici%2C%20Gil%20D">Rabinovici, Gil D</a>; </li><li><a href="/search/?q=author%3AApostolova%2C%20Liana%20G">Apostolova, Liana G</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AConsortium%2C%20the%20LEADS">Consortium, the LEADS</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucsf_postprints">UC San Francisco Previously Published Works</a> (2023)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup"><h3>Introduction</h3>One goal of the Longitudinal Early-onset Alzheimer's Disease Study (LEADS) is to investigate the genetic etiology of early onset (40-64 years) cognitive impairment. Toward this goal, LEADS participants are screened for known pathogenic variants.<h3>Methods</h3>LEADS amyloid-positive early-onset Alzheimer's disease (EOAD) or negative early-onset non-AD (EOnonAD) cases were whole exome sequenced (N = 299). Pathogenic variant frequency in APP, PSEN1, PSEN2, GRN, MAPT, and C9ORF72 was assessed for EOAD and EOnonAD. Gene burden testing was performed in cases compared to similar-age cognitively normal controls in the Parkinson's Progression Markers Initiative (PPMI) study.<h3>Results</h3>Previously reported pathogenic variants in the six genes were identified in 1.35% of EOAD (3/223) and 6.58% of EOnonAD (5/76). No genes showed enrichment for carriers of rare functional variants in LEADS cases.<h3>Discussion</h3>Results suggest that LEADS is enriched for novel genetic causative variants, as previously reported variants are not observed in most cases.<h3>Highlights</h3>Sequencing identified eight cognitively impaired pathogenic variant carriers. Pathogenic variants were identified in PSEN1, GRN, MAPT, and C9ORF72. Rare variants were not enriched in APP, PSEN1/2, GRN, and MAPT. The Longitudinal Early-onset Alzheimer's Disease Study (LEADS) is a key resource for early-onset Alzheimer's genetic research.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/7kd5r07k"><img src="/cms-assets/b433446caf7d4528131f3b586d0fe3e19875bcc38ec61cd42a404eec51c6e8b5" alt="Cover page: Pathogenic variants in the Longitudinal Early‐onset Alzheimer's Disease Study cohort"/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/5rk7n7z4"><div class="c-clientmarkup">Learning slopes in early‐onset Alzheimer's disease</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3AHammers%2C%20Dustin%20B">Hammers, Dustin B</a>; </li><li><a href="/search/?q=author%3ANemes%2C%20S%C3%A1ra">Nemes, Sára</a>; </li><li><a href="/search/?q=author%3ADiedrich%2C%20Taylor">Diedrich, Taylor</a>; </li><li><a href="/search/?q=author%3AEloyan%2C%20Ani">Eloyan, Ani</a>; </li><li><a href="/search/?q=author%3AKirby%2C%20Kala">Kirby, Kala</a>; </li><li><a href="/search/?q=author%3AAisen%2C%20Paul">Aisen, Paul</a>; </li><li><a href="/search/?q=author%3AKramer%2C%20Joel">Kramer, Joel</a>; </li><li><a href="/search/?q=author%3ANudelman%2C%20Kelly">Nudelman, Kelly</a>; </li><li><a href="/search/?q=author%3AForoud%2C%20Tatiana">Foroud, Tatiana</a>; </li><li><a href="/search/?q=author%3ARumbaugh%2C%20Malia">Rumbaugh, Malia</a>; </li><li><a href="/search/?q=author%3AAtri%2C%20Alireza">Atri, Alireza</a>; </li><li><a href="/search/?q=author%3ADay%2C%20Gregory%20S">Day, Gregory S</a>; </li><li><a href="/search/?q=author%3ADuara%2C%20Ranjan">Duara, Ranjan</a>; </li><li><a href="/search/?q=author%3AGraff%E2%80%90Radford%2C%20Neill%20R">Graff‐Radford, Neill R</a>; </li><li><a href="/search/?q=author%3AHonig%2C%20Lawrence%20S">Honig, Lawrence S</a>; </li><li><a href="/search/?q=author%3AJones%2C%20David%20T">Jones, David T</a>; </li><li><a href="/search/?q=author%3AMasdeu%2C%20Joseph%20C">Masdeu, Joseph C</a>; </li><li><a href="/search/?q=author%3AMendez%2C%20Mario%20F">Mendez, Mario F</a>; </li><li><a href="/search/?q=author%3AMusiek%2C%20Erik">Musiek, Erik</a>; </li><li><a href="/search/?q=author%3AOnyike%2C%20Chiadi%20U">Onyike, Chiadi U</a>; </li><li><a href="/search/?q=author%3ARiddle%2C%20Meghan">Riddle, Meghan</a>; </li><li><a href="/search/?q=author%3ARogalski%2C%20Emily">Rogalski, Emily</a>; </li><li><a href="/search/?q=author%3ASalloway%2C%20Steve">Salloway, Steve</a>; </li><li><a href="/search/?q=author%3ASha%2C%20Sharon%20J">Sha, Sharon J</a>; </li><li><a href="/search/?q=author%3ATurner%2C%20Raymond%20Scott">Turner, Raymond Scott</a>; </li><li><a href="/search/?q=author%3AWeintraub%2C%20Sandra">Weintraub, Sandra</a>; </li><li><a href="/search/?q=author%3AWingo%2C%20Thomas%20S">Wingo, Thomas S</a>; </li><li><a href="/search/?q=author%3AWolk%2C%20David%20A">Wolk, David A</a>; </li><li><a href="/search/?q=author%3AWong%2C%20Bonnie">Wong, Bonnie</a>; </li><li><a href="/search/?q=author%3ACarrillo%2C%20Maria%20C">Carrillo, Maria C</a>; </li><li><a href="/search/?q=author%3ADickerson%2C%20Bradford%20C">Dickerson, Bradford C</a>; </li><li><a href="/search/?q=author%3ARabinovici%2C%20Gil%20D">Rabinovici, Gil D</a>; </li><li><a href="/search/?q=author%3AApostolova%2C%20Liana%20G">Apostolova, Liana G</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AConsortium%2C%20the%20LEADS">Consortium, the LEADS</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucsf_postprints">UC San Francisco Previously Published Works</a> (2023)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup"><h3>Objective</h3>Investigation of learning slopes in early-onset dementias has been limited. The current study aimed to highlight the sensitivity of learning slopes to discriminate disease severity in cognitively normal participants and those diagnosed with early-onset dementia with and without β-amyloid positivity METHOD: Data from 310 participants in the Longitudinal Early-Onset Alzheimer's Disease Study (aged 41 to 65) were used to calculate learning slope metrics. Learning slopes among diagnostic groups were compared, and the relationships of slopes with standard memory measures were determined RESULTS: Worse learning slopes were associated with more severe disease states, even after controlling for demographics, total learning, and cognitive severity. A particular metric-the learning ratio (LR)-outperformed other learning slope calculations across analyses CONCLUSIONS: Learning slopes appear to be sensitive to early-onset dementias, even when controlling for the effect of total learning and cognitive severity. The LR may be the learning measure of choice for such analyses.<h3>Highlights</h3>Learning is impaired in amyloid-positive EOAD, beyond cognitive severity scores alone. Amyloid-positive EOAD participants perform worse on learning slopes than amyloid-negative participants. Learning ratio appears to be the learning metric of choice for EOAD participants.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/5rk7n7z4"><img src="/cms-assets/1f907dfa808b0c09cfc6d404e8290f30d5f77cb3c08fdb6abab279c3938f538f" alt="Cover page: Learning slopes in early‐onset Alzheimer's disease"/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/1115g91f"><div class="c-clientmarkup">Influence of amyloid and diagnostic syndrome on non‐traditional memory scores in early‐onset Alzheimer's disease</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3ABushnell%2C%20Justin">Bushnell, Justin</a>; </li><li><a href="/search/?q=author%3AHammers%2C%20Dustin%20B">Hammers, Dustin B</a>; </li><li><a href="/search/?q=author%3AAisen%2C%20Paul">Aisen, Paul</a>; </li><li><a href="/search/?q=author%3ADage%2C%20Jeffrey%20L">Dage, Jeffrey L</a>; </li><li><a href="/search/?q=author%3AEloyan%2C%20Ani">Eloyan, Ani</a>; </li><li><a href="/search/?q=author%3AForoud%2C%20Tatiana">Foroud, Tatiana</a>; </li><li><a href="/search/?q=author%3AGrinberg%2C%20Lea%20T">Grinberg, Lea T</a>; </li><li><a href="/search/?q=author%3AIaccarino%2C%20Leonardo">Iaccarino, Leonardo</a>; </li><li><a href="/search/?q=author%3AJack%2C%20Clifford%20R">Jack, Clifford R</a>; </li><li><a href="/search/?q=author%3AKirby%2C%20Kala">Kirby, Kala</a>; </li><li><a href="/search/?q=author%3AKramer%2C%20Joel">Kramer, Joel</a>; </li><li><a href="/search/?q=author%3AKoeppe%2C%20Robert">Koeppe, Robert</a>; </li><li><a href="/search/?q=author%3AKukull%2C%20Walter%20A">Kukull, Walter A</a>; </li><li><a href="/search/?q=author%3ALa%20Joie%2C%20Renaud">La Joie, Renaud</a>; </li><li><a href="/search/?q=author%3AMundada%2C%20Nidhi%20S">Mundada, Nidhi S</a>; </li><li><a href="/search/?q=author%3AMurray%2C%20Melissa%20E">Murray, Melissa E</a>; </li><li><a href="/search/?q=author%3ANudelman%2C%20Kelly">Nudelman, Kelly</a>; </li><li><a href="/search/?q=author%3ARumbaugh%2C%20Malia">Rumbaugh, Malia</a>; </li><li><a href="/search/?q=author%3ASoleimani%E2%80%90Meigooni%2C%20David%20N">Soleimani‐Meigooni, David N</a>; </li><li><a href="/search/?q=author%3AToga%2C%20Arthur">Toga, Arthur</a>; </li><li><a href="/search/?q=author%3ATouroutoglou%2C%20Alexandra">Touroutoglou, Alexandra</a>; </li><li><a href="/search/?q=author%3AVemuri%2C%20Prashanthi">Vemuri, Prashanthi</a>; </li><li><a href="/search/?q=author%3AAtri%2C%20Alireza">Atri, Alireza</a>; </li><li><a href="/search/?q=author%3ADay%2C%20Gregory%20S">Day, Gregory S</a>; </li><li><a href="/search/?q=author%3ADuara%2C%20Ranjan">Duara, Ranjan</a>; </li><li><a href="/search/?q=author%3AGraff%E2%80%90Radford%2C%20Neill%20R">Graff‐Radford, Neill R</a>; </li><li><a href="/search/?q=author%3AHonig%2C%20Lawrence%20S">Honig, Lawrence S</a>; </li><li><a href="/search/?q=author%3AJones%2C%20David%20T">Jones, David T</a>; </li><li><a href="/search/?q=author%3AMasdeu%2C%20Joseph">Masdeu, Joseph</a>; </li><li><a href="/search/?q=author%3AMendez%2C%20Mario">Mendez, Mario</a>; </li><li><a href="/search/?q=author%3AMusiek%2C%20Erik">Musiek, Erik</a>; </li><li><a href="/search/?q=author%3AOnyike%2C%20Chiadi%20U">Onyike, Chiadi U</a>; </li><li><a href="/search/?q=author%3ARiddle%2C%20Meghan">Riddle, Meghan</a>; </li><li><a href="/search/?q=author%3ARogalski%2C%20Emily">Rogalski, Emily</a>; </li><li><a href="/search/?q=author%3ASalloway%2C%20Steven">Salloway, Steven</a>; </li><li><a href="/search/?q=author%3ASha%2C%20Sharon">Sha, Sharon</a>; </li><li><a href="/search/?q=author%3ATurner%2C%20Raymond%20S">Turner, Raymond S</a>; </li><li><a href="/search/?q=author%3AWingo%2C%20Thomas%20S">Wingo, Thomas S</a>; </li><li><a href="/search/?q=author%3AWolk%2C%20David%20A">Wolk, David A</a>; </li><li><a href="/search/?q=author%3ACarrillo%2C%20Maria%20C">Carrillo, Maria C</a>; </li><li><a href="/search/?q=author%3ADickerson%2C%20Bradford%20C">Dickerson, Bradford C</a>; </li><li><a href="/search/?q=author%3ARabinovici%2C%20Gil%20D">Rabinovici, Gil D</a>; </li><li><a href="/search/?q=author%3AApostolova%2C%20Liana%20G">Apostolova, Liana G</a>; </li><li><a href="/search/?q=author%3AClark%2C%20David%20G">Clark, David G</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AConsortium%2C%20the%20LEADS">Consortium, the LEADS</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucsf_postprints">UC San Francisco Previously Published Works</a> (2023)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup"><h3>Introduction</h3>The Rey Auditory Verbal Learning Test (RAVLT) is a useful neuropsychological test for describing episodic memory impairment in dementia. However, there is limited research on its utility in early-onset Alzheimer's disease (EOAD). We assess the influence of amyloid and diagnostic syndrome on several memory scores in EOAD.<h3>Methods</h3>We transcribed RAVLT recordings from 303 subjects in the Longitudinal Early-Onset Alzheimer's Disease Study. Subjects were grouped by amyloid status and syndrome. Primacy, recency, J-curve, duration, stopping time, and speed score were calculated and entered into linear mixed effects models as dependent variables.<h3>Results</h3>Compared with amyloid negative subjects, positive subjects exhibited effects on raw score, primacy, recency, and stopping time. Inter-syndromic differences were noted with raw score, primacy, recency, J-curve, and stopping time.<h3>Discussion</h3>RAVLT measures are sensitive to the effects of amyloid and syndrome in EOAD. Future work is needed to quantify the predictive value of these scores.<h3>Highlights</h3>RAVLT patterns characterize various presentations of EOAD and EOnonAD Amyloid impacts raw score, primacy, recency, and stopping time Timing-based scores add value over traditional count-based scores.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/1115g91f"><img src="/cms-assets/ec47ff58bff1d9e65d9edf3b11ec81c0d04e649d8b706ba59754ce8cb5f06d71" alt="Cover page: Influence of amyloid and diagnostic syndrome on non‐traditional memory scores in early‐onset Alzheimer's disease"/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/5t92d3h3"><div class="c-clientmarkup">Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer’s disease</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3AJohnson%2C%20Erik%20CB">Johnson, Erik CB</a>; </li><li><a href="/search/?q=author%3ABian%2C%20Shijia">Bian, Shijia</a>; </li><li><a href="/search/?q=author%3AHaque%2C%20Rafi%20U">Haque, Rafi U</a>; </li><li><a href="/search/?q=author%3ACarter%2C%20E%20Kathleen">Carter, E Kathleen</a>; </li><li><a href="/search/?q=author%3AWatson%2C%20Caroline%20M">Watson, Caroline M</a>; </li><li><a href="/search/?q=author%3AGordon%2C%20Brian%20A">Gordon, Brian A</a>; </li><li><a href="/search/?q=author%3APing%2C%20Lingyan">Ping, Lingyan</a>; </li><li><a href="/search/?q=author%3ADuong%2C%20Duc%20M">Duong, Duc M</a>; </li><li><a href="/search/?q=author%3AEpstein%2C%20Michael%20P">Epstein, Michael P</a>; </li><li><a href="/search/?q=author%3AMcDade%2C%20Eric">McDade, Eric</a>; </li><li><a href="/search/?q=author%3ABarth%C3%A9lemy%2C%20Nicolas%20R">Barthélemy, Nicolas R</a>; </li><li><a href="/search/?q=author%3AKarch%2C%20Celeste%20M">Karch, Celeste M</a>; </li><li><a href="/search/?q=author%3AXiong%2C%20Chengjie">Xiong, Chengjie</a>; </li><li><a href="/search/?q=author%3ACruchaga%2C%20Carlos">Cruchaga, Carlos</a>; </li><li><a href="/search/?q=author%3APerrin%2C%20Richard%20J">Perrin, Richard J</a>; </li><li><a href="/search/?q=author%3AWingo%2C%20Aliza%20P">Wingo, Aliza P</a>; </li><li><a href="/search/?q=author%3AWingo%2C%20Thomas%20S">Wingo, Thomas S</a>; </li><li><a href="/search/?q=author%3AChhatwal%2C%20Jasmeer%20P">Chhatwal, Jasmeer P</a>; </li><li><a href="/search/?q=author%3ADay%2C%20Gregory%20S">Day, Gregory S</a>; </li><li><a href="/search/?q=author%3ANoble%2C%20James%20M">Noble, James M</a>; </li><li><a href="/search/?q=author%3ABerman%2C%20Sarah%20B">Berman, Sarah B</a>; </li><li><a href="/search/?q=author%3AMartins%2C%20Ralph">Martins, Ralph</a>; </li><li><a href="/search/?q=author%3AGraff-Radford%2C%20Neill%20R">Graff-Radford, Neill R</a>; </li><li><a href="/search/?q=author%3ASchofield%2C%20Peter%20R">Schofield, Peter R</a>; </li><li><a href="/search/?q=author%3AIkeuchi%2C%20Takeshi">Ikeuchi, Takeshi</a>; </li><li><a href="/search/?q=author%3AMori%2C%20Hiroshi">Mori, Hiroshi</a>; </li><li><a href="/search/?q=author%3ALevin%2C%20Johannes">Levin, Johannes</a>; </li><li><a href="/search/?q=author%3AFarlow%2C%20Martin">Farlow, Martin</a>; </li><li><a href="/search/?q=author%3ALah%2C%20James%20J">Lah, James J</a>; </li><li><a href="/search/?q=author%3AHaass%2C%20Christian">Haass, Christian</a>; </li><li><a href="/search/?q=author%3AJucker%2C%20Mathias">Jucker, Mathias</a>; </li><li><a href="/search/?q=author%3AMorris%2C%20John%20C">Morris, John C</a>; </li><li><a href="/search/?q=author%3ABenzinger%2C%20Tammie%20LS">Benzinger, Tammie LS</a>; </li><li><a href="/search/?q=author%3ARoberts%2C%20Blaine%20R">Roberts, Blaine R</a>; </li><li><a href="/search/?q=author%3ABateman%2C%20Randall%20J">Bateman, Randall J</a>; </li><li><a href="/search/?q=author%3AFagan%2C%20Anne%20M">Fagan, Anne M</a>; </li><li><a href="/search/?q=author%3ASeyfried%2C%20Nicholas%20T">Seyfried, Nicholas T</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3ALevey%2C%20Allan%20I">Levey, Allan I</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucd_postprints">UC Davis Previously Published Works</a> (2023)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup">Alzheimer's disease (AD) pathology develops many years before the onset of cognitive symptoms. Two pathological processes-aggregation of the amyloid-β (Aβ) peptide into plaques and the microtubule protein tau into neurofibrillary tangles (NFTs)-are hallmarks of the disease. However, other pathological brain processes are thought to be key disease mediators of Aβ plaque and NFT pathology. How these additional pathologies evolve over the course of the disease is currently unknown. Here we show that proteomic measurements in autosomal dominant AD cerebrospinal fluid (CSF) linked to brain protein coexpression can be used to characterize the evolution of AD pathology over a timescale spanning six decades. SMOC1 and SPON1 proteins associated with Aβ plaques were elevated in AD CSF nearly 30 years before the onset of symptoms, followed by changes in synaptic proteins, metabolic proteins, axonal proteins, inflammatory proteins and finally decreases in neurosecretory proteins. The proteome discriminated mutation carriers from noncarriers before symptom onset as well or better than Aβ and tau measures. Our results highlight the multifaceted landscape of AD pathophysiology and its temporal evolution. Such knowledge will be critical for developing precision therapeutic interventions and biomarkers for AD beyond those associated with Aβ and tau.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/5t92d3h3"><img src="/cms-assets/ea9783d073b3e2a19c21757f021048f6ff91cb0590f4a53b4dd8d392150ead84" alt="Cover page: Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer’s disease"/></a></div></section><nav class="c-pagination"><ul><li><a href="" aria-label="you are on result set 1" class="c-pagination__item--current">1</a></li><li><a href="" aria-label="go to result set 2" class="c-pagination__item">2</a></li><li><a href="" aria-label="go to result set 3" class="c-pagination__item">3</a></li></ul></nav></section></main></form></div><div><div class="c-toplink"><a href="javascript:window.scrollTo(0, 0)">Top</a></div><footer class="c-footer"><nav class="c-footer__nav"><ul><li><a href="/">Home</a></li><li><a href="/aboutEschol">About eScholarship</a></li><li><a href="/campuses">Campus Sites</a></li><li><a href="/ucoapolicies">UC Open Access Policy</a></li><li><a href="/publishing">eScholarship Publishing</a></li><li><a href="https://www.cdlib.org/about/accessibility.html">Accessibility</a></li><li><a href="/privacypolicy">Privacy Statement</a></li><li><a href="/policies">Site Policies</a></li><li><a href="/terms">Terms of Use</a></li><li><a href="/login"><strong>Admin Login</strong></a></li><li><a href="https://help.escholarship.org"><strong>Help</strong></a></li></ul></nav><div class="c-footer__logo"><a href="/"><img class="c-lazyimage" data-src="/images/logo_footer-eschol.svg" alt="eScholarship, University of California"/></a></div><div class="c-footer__copyright">Powered by the<br/><a href="http://www.cdlib.org">California Digital Library</a><br/>Copyright © 2017<br/>The Regents of the University of California</div></footer></div></div></div></div> <script src="/js/vendors~app-bundle-2aefc956e545366a5d4e.js"></script> <script src="/js/app-bundle-4477d7630fb8c6f70662.js"></script> </body> </html>