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name="rows" id="c-sort2" form="facetForm"><option selected="" value="10">10</option><option value="20">20</option><option value="30">30</option><option value="40">40</option><option value="50">50</option></select></div></div><input type="hidden" name="start" form="facetForm" value="0"/><nav class="c-pagination"><ul><li><a href="" aria-label="you are on result set 1" class="c-pagination__item--current">1</a></li><li><a href="" aria-label="go to result set 2" class="c-pagination__item">2</a></li><li><a href="" aria-label="go to result set 3" class="c-pagination__item">3</a></li><li><a href="" aria-label="go to result set 4" class="c-pagination__item">4</a></li><li><a href="" aria-label="go to result set 5" class="c-pagination__item">5</a></li></ul></nav></div><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/2z45n7rx"><div class="c-clientmarkup">Early-Onset Alzheimer Disease</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3AMendez%2C%20Mario%20F">Mendez, Mario F</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucla_postprints">UCLA Previously Published Works</a> (2017)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup">Early-onset Alzheimer disease (EOAD), with onset in individuals younger than 65 years, although overshadowed by the more common late-onset AD (LOAD), differs significantly from LOAD. EOAD comprises approximately 5% of AD and is associated with delays in diagnosis, aggressive course, and age-related psychosocial needs. One source of confusion is that a substantial percentage of EOAD are phenotypic variants that differ from the usual memory-disordered presentation of typical AD. The management of EOAD is similar to that for LOAD, but special emphasis should be placed on targeting the specific cognitive areas involved and more age-appropriate psychosocial support and education.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/2z45n7rx"><img src="/cms-assets/2274584de2f004a47e14e196f1705dc0d151ce4c6e6843dd88b6c6e82507749e" alt="Cover page: Early-Onset Alzheimer Disease"/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/6jg2t9w7"><div class="c-clientmarkup">Epilepsy partialis continua with visual allesthesia</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3AMendez%2C%20Mario%20F.">Mendez, Mario F.</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AChen%2C%20James%20W.">Chen, James W.</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucla_postprints">UCLA Previously Published Works</a> (2009)</div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/6jg2t9w7"><img src="/cms-assets/b9d79dfad322eb639516128daaf5d8c215367c630d7f3a22b73c32527a806c27" alt="Cover page: Epilepsy partialis continua with visual allesthesia"/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/2q77m3kv"><div class="c-clientmarkup">Bilingualism in older Mexican-American immigrants is associated with higher scores on cognitive screening</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3APadilla%2C%20Claudia">Padilla, Claudia</a>; </li><li><a href="/search/?q=author%3AMendez%2C%20Mario%20F">Mendez, Mario F</a>; </li><li><a href="/search/?q=author%3AJimenez%2C%20Elvira%20E">Jimenez, Elvira E</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3ATeng%2C%20Edmond">Teng, Edmond</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucla_postprints">UCLA Previously Published Works</a> (2016)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup"><h3>Background</h3>Bilingualism may protect against cognitive aging and delay the onset of dementia. However, studies comparing monolinguals and bilinguals on such metrics have produced inconsistent results complicated by confounding variables and methodological concerns.<h3>Methods</h3>We addressed this issue by comparing cognitive performance in a more culturally homogeneous cohort of older Spanish-speaking monolingual (n = 289) and Spanish-English bilingual (n = 339) Mexican-American immigrants from the Sacramento Longitudinal Study on Aging.<h3>Results</h3>After adjusting for demographic differences and depressive symptoms, both groups performed similarly at baseline on verbal memory but the bilingual group performed significantly better than the monolingual group on a cognitive screening test, the Modified Mini-Mental State Examination (3MS; p < 0.001). Group differences on the 3MS were driven by language/executive and language/praxis factors. Within the bilingual group, neither language of testing nor degree of bilingualism was significantly associated with 3MS or verbal memory scores. Amongst individuals who performed in the normal or better range on both tests at baseline and were followed for an average of 6 years, both monolinguals and bilinguals exhibited similar rates of cognitive decline on both measures.<h3>Conclusions</h3>These findings suggest that bilingualism is associated with modest benefits in cognitive screening performance in older individuals in cross-sectional analyses that persist across longitudinal analyses. The effects of bilingualism should be considered when cognitively screening is performed in aging immigrant populations.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/2q77m3kv"><img src="/cms-assets/20aafb52e25719eacc3938acebbe280910f2d1aaf7eb73308fb6a31bd5817d3e" alt="Cover page: Bilingualism in older Mexican-American immigrants is associated with higher scores on cognitive screening"/></a><a href="https://creativecommons.org/licenses/by/4.0/" class="c-scholworks__license"><img class="c-lazyimage" data-src="/images/cc-by-small.svg" alt="Creative Commons 'BY' version 4.0 license"/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/02f2g1sg"><div class="c-clientmarkup">Benson's Disease or Posterior Cortical Atrophy, Revisited.</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3AYerstein%2C%20Oleg">Yerstein, Oleg</a>; </li><li><a href="/search/?q=author%3AParand%2C%20Leila">Parand, Leila</a>; </li><li><a href="/search/?q=author%3ALiang%2C%20Li-Jung">Liang, Li-Jung</a>; </li><li><a href="/search/?q=author%3AIsaac%2C%20Adrienne">Isaac, Adrienne</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AMendez%2C%20Mario%20F">Mendez, Mario F</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucla_postprints">UCLA Previously Published Works</a> (2021)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup"><h3>Background</h3>D. Frank Benson and colleagues first described the clinical and neuropathological features of posterior cortical atrophy (PCA) from patients in the UCLA Neurobehavior Program.<h3>Objective</h3>We reviewed the Program's subsequent clinical experience with PCA, and its potential for clarifying this relatively rare syndrome in comparison to the accumulated literature on PCA.<h3>Methods</h3>Using the original criteria derived from this clinic, 65 patients with neuroimaging-supported PCA were diagnosed between 1995 and 2020.<h3>Results</h3>On presentation, most had visual localization complaints and related visuospatial symptoms, but nearly half had memory complaints followed by symptoms of depression. Neurobehavioral testing showed predominant difficulty with visuospatial constructions, Gerstmann's syndrome, and Balint's syndrome, but also impaired memory and naming. On retrospective application of the current Consensus Criteria for PCA, 59 (91%) met PCA criteria with a modification allowing for "significantly greater visuospatial over memory and naming deficits." There were 37 deaths (56.9%) with the median overall survival of 10.3 years (95% CI: 9.6-13.6 years), consistent with a slow neurodegenerative disorder in most patients.<h3>Conclusion</h3>Together, these findings recommend modifying the PCA criteria for "relatively spared" memory, language, and behavior to include secondary memory and naming difficulty and depression, with increased emphasis on the presence of Gerstmann's and Balint's syndromes.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/02f2g1sg"><img src="/cms-assets/fad2b0283088982ca78cbec40b40ba50c28f59673c0d61f53a2549616c271a2d" alt="Cover page: Benson's Disease or Posterior Cortical Atrophy, Revisited."/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/3fp390b7"><div class="c-clientmarkup">A Scale of Socioemotional Dysfunction in Frontotemporal Dementia</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3ABarsuglia%2C%20Joseph%20P">Barsuglia, Joseph P</a>; </li><li><a href="/search/?q=author%3AKaiser%2C%20Natalie%20C">Kaiser, Natalie C</a>; </li><li><a href="/search/?q=author%3AWilkins%2C%20Stacy%20Schantz">Wilkins, Stacy Schantz</a>; </li><li><a href="/search/?q=author%3AJoshi%2C%20Aditi">Joshi, Aditi</a>; </li><li><a href="/search/?q=author%3ABarrows%2C%20Robin%20J">Barrows, Robin J</a>; </li><li><a href="/search/?q=author%3APaholpak%2C%20Pongsatorn">Paholpak, Pongsatorn</a>; </li><li><a href="/search/?q=author%3APanchal%2C%20Hemali%20Vijay">Panchal, Hemali Vijay</a>; </li><li><a href="/search/?q=author%3AJimenez%2C%20Elvira%20E">Jimenez, Elvira E</a>; </li><li><a href="/search/?q=author%3AMather%2C%20Michelle%20J">Mather, Michelle J</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AMendez%2C%20Mario%20F">Mendez, Mario F</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucla_postprints">UCLA Previously Published Works</a> (2014)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup">Early social dysfunction is a hallmark symptom of behavioral variant frontotemporal dementia (bvFTD); however, validated measures for assessing social deficits in dementia are needed. The purpose of the current study was to examine the utility of a novel informant-based measure of social impairment, the Socioemotional Dysfunction Scale (SDS) in early-onset dementia. Sixteen bvFTD and 18 early-onset Alzheimer's disease (EOAD) participants received standard clinical neuropsychological measures and neuroimaging. Caregiver informants were administered the SDS. Individuals with bvFTD exhibited greater social dysfunction on the SDS compared with the EOAD group; t(32) = 6.32, p < .001. The scale demonstrated preliminary evidence for discriminating these frequently misdiagnosed groups (area under the curve = 0.920, p = <.001) and internal consistency α = 0.977. The SDS demonstrated initial evidence as an effective measure for detecting abnormal social behavior and discriminating bvFTD from EOAD. Future validation is recommended in larger and more diverse patient groups.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/3fp390b7"><img src="/cms-assets/c528badedc27e33a623aa295d92f675d805bb31161c318f513856a4ea72a5c19" alt="Cover page: A Scale of Socioemotional Dysfunction in Frontotemporal Dementia"/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/0r14x8ff"><div class="c-clientmarkup">Demographics, Symptoms, Psychotropic Use, and Caregiver Distress in Patients with Early vs Late Onset Dementia</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3ALee%2C%20David%20R">Lee, David R</a>; </li><li><a href="/search/?q=author%3ARomero%2C%20Tahmineh">Romero, Tahmineh</a>; </li><li><a href="/search/?q=author%3ASerrano%2C%20Katherine">Serrano, Katherine</a>; </li><li><a href="/search/?q=author%3APanlilio%2C%20Michelle">Panlilio, Michelle</a>; </li><li><a href="/search/?q=author%3ARojas-Parra%2C%20Abel">Rojas-Parra, Abel</a>; </li><li><a href="/search/?q=author%3AMatsuno%2C%20Lauren">Matsuno, Lauren</a>; </li><li><a href="/search/?q=author%3AMendez%2C%20Mario%20F">Mendez, Mario F</a>; </li><li><a href="/search/?q=author%3AWillinger%2C%20Christine">Willinger, Christine</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AReuben%2C%20David%20B">Reuben, David B</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucla_postprints">UCLA Previously Published Works</a> (2024)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup"><h3>Background</h3>Understanding experiences and challenges faced by persons living with Early-Onset Dementia (EOD) compared to individuals diagnosed with Late-Onset Dementia (LOD) is important for the development of targeted interventions.<h3>Objective</h3>Describe differences in sociodemographic, neuropsychiatric behavioral symptoms, caregiver characteristics, and psychotropic use.<h3>Design, setting, participants</h3>Cross-sectional, retrospective study including 908 UCLA Alzheimer's Dementia Care Program participants (177 with EOD and 731 with LOD).<h3>Measurements</h3>Onset of dementia was determined using age at program enrollment, with EOD defined as age <65 years and LOD defined as age >80 years. Sociodemographic and clinical characteristics were measured once at enrollment. Behavioral symptoms were measured using the Neuropsychiatric Inventory Questionnaire (NPI-Q) severity score and caregiver distress was measured using the NPI-Q distress score. Medications included antipsychotic, antidepressant, benzodiazepines and other hypnotics, antiepileptics, and dementia medications.<h3>Results</h3>EOD compared to LOD participants were more likely men, college graduates, married, live alone, and have fewer comorbidities. EOD caregivers were more often spouses (56% vs 26%, p <0.01), whereas LOD caregivers were more often children (57% vs 10%, p <0.01). EOD was associated with lower odds of being above the median (worse) NPI-Q severity (adjusted odds ratio [aOR], 0.58; 95% CI 0.35-0.96) and NPI-Q distress scores (aOR, 0.53; 95% CI 0.31-0.88). Psychotropic use did not differ between groups though symptoms were greater for LOD compared to EOD.<h3>Conclusion</h3>Persons with EOD compared to LOD had sociodemographic differences, less health conditions, and fewer neuropsychiatric symptoms. Future policies could prioritize counseling for EOD patients and families, along with programs to support spousal caregivers of persons with EOD.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/0r14x8ff"><img src="/cms-assets/6c717914d942b3afec436b5e629ca4b13a1eaf531c7aef38f4c0cf4350217c6a" alt="Cover page: Demographics, Symptoms, Psychotropic Use, and Caregiver Distress in Patients with Early vs Late Onset Dementia"/></a><a href="https://creativecommons.org/licenses/by/4.0/" class="c-scholworks__license"><img class="c-lazyimage" data-src="/images/cc-by-small.svg" alt="Creative Commons 'BY' version 4.0 license"/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/04v366gq"><div class="c-clientmarkup">Patient and caregiver reactions to clinical amyloid imaging</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3AGrill%2C%20Joshua%20D">Grill, Joshua D</a>; </li><li><a href="/search/?q=author%3ACox%2C%20Chelsea%20G">Cox, Chelsea G</a>; </li><li><a href="/search/?q=author%3AKremen%2C%20Sarah">Kremen, Sarah</a>; </li><li><a href="/search/?q=author%3AMendez%2C%20Mario%20F">Mendez, Mario F</a>; </li><li><a href="/search/?q=author%3ATeng%2C%20Edmond">Teng, Edmond</a>; </li><li><a href="/search/?q=author%3AShapira%2C%20Jill">Shapira, Jill</a>; </li><li><a href="/search/?q=author%3ARingman%2C%20John%20M">Ringman, John M</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AApostolova%2C%20Liana%20G">Apostolova, Liana G</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/uci_postprints">UC Irvine Previously Published Works</a> (2017)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup"><h3>Introduction</h3>Amyloid imaging is a tool that has recently become available to dementia specialists evaluating patients with possible Alzheimer's disease. Studies have assessed the impact of amyloid imaging on diagnostic and treatment decisions, but patient and family perspectives have received less attention.<h3>Methods</h3>To examine how amyloid imaging affects the diagnostic experience of patients and families, we interviewed members of 26 patient-caregiver dyads with whom a neurologist discussed the option of amyloid positron emission tomography.<h3>Results</h3>Most participants who chose to undergo amyloid imaging would choose to do so again. Regardless of the scan outcome, patients and caregivers commonly expressed relief on learning the scan results. Some participants expressed expectations that were beyond scan capabilities.<h3>Discussion</h3>Amyloid imaging may provide information that patients and their families find useful. Clinicians must set correct expectations and ensure that families understand the limitations of amyloid imaging.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/04v366gq"><img src="/cms-assets/6f058883f91b522f332bc81a3bb5089bcd0603a073d93cc80369359e8891952e" alt="Cover page: Patient and caregiver reactions to clinical amyloid imaging"/></a><a href="https://creativecommons.org/licenses/by/4.0/" class="c-scholworks__license"><img class="c-lazyimage" data-src="/images/cc-by-small.svg" alt="Creative Commons 'BY' version 4.0 license"/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/15n6z4qf"><div class="c-clientmarkup">The A431E mutation in PSEN1 causing Familial Alzheimer’s Disease originating in Jalisco State, Mexico: an additional fifteen families</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3AMurrell%2C%20Jill">Murrell, Jill</a>; </li><li><a href="/search/?q=author%3AGhetti%2C%20Bernardino">Ghetti, Bernardino</a>; </li><li><a href="/search/?q=author%3ACochran%2C%20Elizabeth">Cochran, Elizabeth</a>; </li><li><a href="/search/?q=author%3AMacias-Islas%2C%20Miguel%20Angel">Macias-Islas, Miguel Angel</a>; </li><li><a href="/search/?q=author%3AMedina%2C%20Luis">Medina, Luis</a>; </li><li><a href="/search/?q=author%3AVarpetian%2C%20Arousiak">Varpetian, Arousiak</a>; </li><li><a href="/search/?q=author%3ACummings%2C%20Jeffrey%20L">Cummings, Jeffrey L</a>; </li><li><a href="/search/?q=author%3AMendez%2C%20Mario%20F">Mendez, Mario F</a>; </li><li><a href="/search/?q=author%3AKawas%2C%20Claudia">Kawas, Claudia</a>; </li><li><a href="/search/?q=author%3AChui%2C%20Helena">Chui, Helena</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3ARingman%2C%20John%20M">Ringman, John M</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/uci_postprints">UC Irvine Previously Published Works</a> (2006)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup">Nine families with autosomal dominant Alzheimer's disease (AD), all of whom had the Ala431Glu substitution in the PSEN1 gene and came from Jalisco State in Mexico, have been previously reported. As they shared highly polymorphic flanking dinucleotide marker alleles, this strongly suggests that this mutation arose from a common founder. In the current letter, we expand this observation by describing an additional 15 independent families with the Ala431Glu substitution in the PSEN1 gene and conclude that this mutation is not an uncommon cause of early-onset autosomal dominant AD in persons of Mexican origin.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/15n6z4qf"><img src="/cms-assets/107195ab410af96cc81d6c16c8d816960ec770e7be4b7a164d41592ccd76e9cc" alt="Cover page: The A431E mutation in PSEN1 causing Familial Alzheimer’s Disease originating in Jalisco State, Mexico: an additional fifteen families"/></a><a href="https://creativecommons.org/licenses/by/4.0/" class="c-scholworks__license"><img class="c-lazyimage" data-src="/images/cc-by-small.svg" alt="Creative Commons 'BY' version 4.0 license"/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/4j2722qc"><div class="c-clientmarkup">PET Imaging of Neuropathology in Tauopathies: Progressive Supranuclear Palsy</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3AKepe%2C%20Vladimir">Kepe, Vladimir</a>; </li><li><a href="/search/?q=author%3ABordelon%2C%20Yvette">Bordelon, Yvette</a>; </li><li><a href="/search/?q=author%3ABoxer%2C%20Adam">Boxer, Adam</a>; </li><li><a href="/search/?q=author%3AHuang%2C%20Sung-Cheng">Huang, Sung-Cheng</a>; </li><li><a href="/search/?q=author%3ALiu%2C%20Jie">Liu, Jie</a>; </li><li><a href="/search/?q=author%3AThiede%2C%20Frederick%20C">Thiede, Frederick C</a>; </li><li><a href="/search/?q=author%3AMazziotta%2C%20John%20C">Mazziotta, John C</a>; </li><li><a href="/search/?q=author%3AMendez%2C%20Mario%20F">Mendez, Mario F</a>; </li><li><a href="/search/?q=author%3ADonoghue%2C%20Natacha">Donoghue, Natacha</a>; </li><li><a href="/search/?q=author%3ASmall%2C%20Gary%20W">Small, Gary W</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3ABarrio%2C%20Jorge%20R">Barrio, Jorge R</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucla_postprints">UCLA Previously Published Works</a> (2013)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup"><h3>Objective</h3>Currently [18F]FDDNP is the only PET imaging probe with the ability to visualize hyperphosphorylated tau fibrillar aggregates in living subjects. In this work, we evaluate in vivo [18F]FDDNP labeling of brain neuropathology, primarily tau fibrillar aggregates, in patients with progressive supranuclear palsy (PSP), a human tauopathy usually lacking amyloid-β deposits.<h3>Methods</h3>Fifteen patients with PSP received [18F]FDDNP PET scanning. [18F]FDDNP distribution volume ratios, in reference to cerebellar gray matter, were determined for cortical and subcortical areas and compared with those of patients with Parkinson's disease with short disease duration, and age-matched control subjects without neurodegenerative disorders.<h3>Results</h3>[18F]FDDNP binding was present in subcortical areas (e.g., striatum, thalamus, subthalamic region, midbrain, and cerebellar white matter) regardless of disease severity, with progressive subcortical and cortical involvement as disease severity increased. Brain patterns of [18F]FDDNP binding were entirely consistent with the known pathology distribution for PSP. High midbrain and subthalamic region [18F]FDDNP binding was distinctive for PSP subjects and separated them from controls and patients with Parkinson's disease.<h3>Conclusions</h3>These results provide evidence that [18F]FDDNP is a sensitive in vivo PET imaging probe to map and quantify the dynamic regional localization of tau fibrillar aggregates in PSP. Furthermore, [18F]FDDNP PET may provide a tool to detect changes in tau pathology distribution either associated with disease progression or as a treatment biomarker for future tau-specific therapies. Patterns of [18F]FDDNP binding may also be useful in diagnosis early in disease presentation when clinical distinction among neurodegenerative disorders is often difficult.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/4j2722qc"><img src="/cms-assets/0d48dc033145d58066400d92c3d6e9462177ffc52955e7326678987c6f934159" alt="Cover page: PET Imaging of Neuropathology in Tauopathies: Progressive Supranuclear Palsy"/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/3223z8mz"><div class="c-clientmarkup">Critical review of the Appropriate Use Criteria for amyloid imaging: Effect on diagnosis and patient care</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3AApostolova%2C%20Liana%20G">Apostolova, Liana G</a>; </li><li><a href="/search/?q=author%3AHaider%2C%20Janelle%20M">Haider, Janelle M</a>; </li><li><a href="/search/?q=author%3AGoukasian%2C%20Naira">Goukasian, Naira</a>; </li><li><a href="/search/?q=author%3ARabinovici%2C%20Gil%20D">Rabinovici, Gil D</a>; </li><li><a href="/search/?q=author%3ACh%C3%A9telat%2C%20Gael">Chételat, Gael</a>; </li><li><a href="/search/?q=author%3ARingman%2C%20John%20M">Ringman, John M</a>; </li><li><a href="/search/?q=author%3AKremen%2C%20Sarah">Kremen, Sarah</a>; </li><li><a href="/search/?q=author%3AGrill%2C%20Joshua%20D">Grill, Joshua D</a>; </li><li><a href="/search/?q=author%3ARestrepo%2C%20Lucas">Restrepo, Lucas</a>; </li><li><a href="/search/?q=author%3AMendez%2C%20Mario%20F">Mendez, Mario F</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3ASilverman%2C%20Daniel%20H">Silverman, Daniel H</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/uci_postprints">UC Irvine Previously Published Works</a> (2016)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup"><h3>Introduction</h3>The utility of the Appropriate Use Criteria (AUC) for amyloid imaging is not established.<h3>Methods</h3>Fifty-three cognitively impaired patients with clinical F<sup>18</sup>-florbetapir imaging were classified as early and late onset, as well as AUC-consistent or AUC-inconsistent. Chi-square statistics and <i>t</i> test were used to compare demographic characteristics and clinical outcomes as appropriate.<h3>Results</h3>Early-onset patients were more likely to be amyloid positive. Change in diagnosis was more frequent in late-onset cases. Change in therapy was more common in early-onset cases. AUC-consistent and AUC-inconsistent cases had comparable rates of amyloid positivity. We saw no difference in the rate of treatment changes in the AUC-consistent group as opposed to the AUC-inconsistent group.<h3>Discussion</h3>The primary role of amyloid imaging in the early-onset group was to confirm the clinically suspected etiology, and in the late-onset group in detecting amyloid-negative cases. The rate of therapeutic changes was significantly greater in the early-onset cases.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/3223z8mz"><img src="/cms-assets/ad1112b19c0c09dfe8795bf0f0b1b25fe6ad8a5f684ad37cc44ea029ab6f9821" alt="Cover page: Critical review of the Appropriate Use Criteria for amyloid imaging: Effect on diagnosis and patient care"/></a></div></section><nav class="c-pagination"><ul><li><a href="" aria-label="you are on result set 1" class="c-pagination__item--current">1</a></li><li><a href="" aria-label="go to result set 2" class="c-pagination__item">2</a></li><li><a href="" aria-label="go to result set 3" class="c-pagination__item">3</a></li><li><a href="" aria-label="go to result set 4" class="c-pagination__item">4</a></li><li><a href="" aria-label="go to result set 5" class="c-pagination__item">5</a></li></ul></nav></section></main></form></div><div><div class="c-toplink"><a href="javascript:window.scrollTo(0, 0)">Top</a></div><footer class="c-footer"><nav class="c-footer__nav"><ul><li><a href="/">Home</a></li><li><a href="/aboutEschol">About eScholarship</a></li><li><a href="/campuses">Campus Sites</a></li><li><a href="/ucoapolicies">UC Open Access Policy</a></li><li><a href="/publishing">eScholarship Publishing</a></li><li><a href="https://www.cdlib.org/about/accessibility.html">Accessibility</a></li><li><a href="/privacypolicy">Privacy Statement</a></li><li><a href="/policies">Site Policies</a></li><li><a href="/terms">Terms of Use</a></li><li><a href="/login"><strong>Admin Login</strong></a></li><li><a href="https://help.escholarship.org"><strong>Help</strong></a></li></ul></nav><div class="c-footer__logo"><a href="/"><img class="c-lazyimage" data-src="/images/logo_footer-eschol.svg" alt="eScholarship, University of California"/></a></div><div class="c-footer__copyright">Powered by the<br/><a href="http://www.cdlib.org">California Digital Library</a><br/>Copyright © 2017<br/>The Regents of the University of California</div></footer></div></div></div></div> <script src="/js/vendors~app-bundle-2aefc956e545366a5d4e.js"></script> <script src="/js/app-bundle-4477d7630fb8c6f70662.js"></script> </body> </html>