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<span>Clinical significance</span> </div> </a> <ul id="toc-Clinical_significance-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Pharmacogenetics" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Pharmacogenetics"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Pharmacogenetics</span> </div> </a> <ul id="toc-Pharmacogenetics-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Interactive_pathway_map" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Interactive_pathway_map"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Interactive pathway map</span> </div> </a> <ul id="toc-Interactive_pathway_map-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-See_also" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#See_also"> 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title="UGT1A1">UGT1A1</a>)</span></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Enzyme found in humans</div> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">UGT1A1</th></tr><tr><td colspan="4" style="text-align:center"></td></tr><tr><th colspan="4" style="text-align:center;background-color:#ddd">Identifiers</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/12530">UGT1A1</a></span>, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT 1-1, UGT1, UGT1A, UDP glucuronosyltransferase family 1 member A1</td></tr><tr><th scope="row" style="background-color:#c3fdb8">External IDs</th><td colspan="3" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/191740">191740</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:98898">98898</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=128034">128034</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=UGT1A1">UGT1A1</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000241635">UGT1A1 - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_2.svg" class="mw-file-description" title="Chromosome 2 (human)"><img alt="Chromosome 2 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Ideogram_human_chromosome_2.svg/300px-Ideogram_human_chromosome_2.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Ideogram_human_chromosome_2.svg/450px-Ideogram_human_chromosome_2.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Ideogram_human_chromosome_2.svg/600px-Ideogram_human_chromosome_2.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Chromosome_2_(human)" class="mw-redirect" title="Chromosome 2 (human)">Chromosome 2 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_2_ideogram.svg" class="mw-file-description" title="Chromosome 2 (human)"><img alt="Chromosome 2 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/7/77/Human_chromosome_2_ideogram.svg/300px-Human_chromosome_2_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/77/Human_chromosome_2_ideogram.svg/450px-Human_chromosome_2_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/77/Human_chromosome_2_ideogram.svg/600px-Human_chromosome_2_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 278.49929660657px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for UGT1A1"><img alt="Genomic location for UGT1A1" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 284.5px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for UGT1A1"><img alt="Genomic location for UGT1A1" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">2q37.1</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">233,760,270 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">233,773,300 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_1.svg" class="mw-file-description" title="Chromosome 1 (mouse)"><img alt="Chromosome 1 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Ideogram_house_mouse_chromosome_1.svg/260px-Ideogram_house_mouse_chromosome_1.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Ideogram_house_mouse_chromosome_1.svg/390px-Ideogram_house_mouse_chromosome_1.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Ideogram_house_mouse_chromosome_1.svg/520px-Ideogram_house_mouse_chromosome_1.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks">Chromosome 1 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_1.svg" class="mw-file-description" title="Chromosome 1 (mouse)"><img alt="Chromosome 1 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/5/5b/Ideogram_of_house_mouse_chromosome_1.svg/300px-Ideogram_of_house_mouse_chromosome_1.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/5b/Ideogram_of_house_mouse_chromosome_1.svg/450px-Ideogram_of_house_mouse_chromosome_1.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/5b/Ideogram_of_house_mouse_chromosome_1.svg/600px-Ideogram_of_house_mouse_chromosome_1.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 127.23201543223px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for UGT1A1"><img alt="Genomic location for UGT1A1" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 133.2px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for UGT1A1"><img alt="Genomic location for UGT1A1" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">1 D|1 44.55 cM</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">88,139,681 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">88,146,719 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000241635">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">duodenum</li><br /><li style="line-height: 137%;">right lobe of liver</li><br /><li style="line-height: 137%;">testicle</li><br /><li style="line-height: 137%;">mucosa of transverse colon</li><br /><li style="line-height: 137%;">human kidney</li><br /><li style="line-height: 137%;">rectum</li><br /><li style="line-height: 137%;">urinary bladder</li><br /><li style="line-height: 137%;">renal cortex</li><br /><li style="line-height: 137%;">gallbladder</li><br /><li style="line-height: 137%;">olfactory zone of nasal mucosa</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000089960">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">duodenum</li><br /><li style="line-height: 137%;">jejunum</li><br /><li style="line-height: 137%;">ileum</li><br /><li style="line-height: 137%;">lip</li><br /><li style="line-height: 137%;">colon</li><br /><li style="line-height: 137%;">hepatobiliary system</li><br /><li style="line-height: 137%;">liver</li><br /><li style="line-height: 137%;">vasculature of organ</li><br /><li style="line-height: 137%;">zone of skin</li><br /><li style="line-height: 137%;">ventricular system</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000241635">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:#eee">n/a</td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Molecular function</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016740">transferase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004857">enzyme inhibitor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001972">retinoic acid binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016758">hexosyltransferase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042803">protein homodimerization activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016757">glycosyltransferase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005496">steroid binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046982">protein heterodimerization activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0019899">enzyme binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0015020">glucuronosyltransferase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008194">UDP-glycosyltransferase activity</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Cellular component</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016021">integral component of membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005789">endoplasmic reticulum membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016020">membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043231">intracellular membrane-bounded organelle</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005887">integral component of plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070069">cytochrome complex</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0034663">endoplasmic reticulum chaperone complex</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005783">endoplasmic reticulum</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Biological process</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008202">steroid metabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0014070">response to organic cyclic compound</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071361">cellular response to ethanol</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008210">estrogen metabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007584">response to nutrient</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045939">negative regulation of steroid metabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006789">bilirubin conjugation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048545">response to steroid hormone</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051384">response to glucocorticoid</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042573">retinoic acid metabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:2001030">negative regulation of cellular glucuronidation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010033">response to organic substance</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032496">response to lipopolysaccharide</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032870">cellular response to hormone stimulus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042167">heme catabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071385">cellular response to glucocorticoid stimulus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006953">acute-phase response</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046483">heterocycle metabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031100">animal organ regeneration</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042594">response to starvation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051552">flavone metabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001889">liver development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008152">metabolism</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1904224">negative regulation of glucuronosyltransferase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045471">response to ethanol</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045922">negative regulation of fatty acid metabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070980">biphenyl catabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071392">cellular response to estradiol stimulus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0052696">flavonoid glucuronidation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0052695">cellular glucuronidation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0052697">xenobiotic glucuronidation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071466">cellular response to xenobiotic stimulus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043086">negative regulation of catalytic activity</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:#eee;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:#c3fdb8">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=54658&rn=1">54658</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=394436&rn=1">394436</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000241635;db=core">ENSG00000241635</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000089960;db=core">ENSMUSG00000089960</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P22309">P22309</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q63886">Q63886</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_000463">NM_000463</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_201645">NM_201645</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_000454">NP_000454</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_964007">NP_964007</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr2:233760270-233773300">Chr 2: 233.76 – 233.77 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr1:88139681-88146719">Chr 1: 88.14 – 88.15 Mb</a></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14901445" class="extiw" title="d:Q14901445">View/Edit Human</a></td><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14901446" class="extiw" title="d:Q14901446">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>UDP-glucuronosyltransferase 1-1</b> also known as <b>UGT-1A</b> is an <a href="/wiki/Enzyme" title="Enzyme">enzyme</a> that in humans is encoded by the <i>UGT1A1</i> <a href="/wiki/Gene" title="Gene">gene</a>.<sup id="cite_ref-pmid9295054_5-0" class="reference"><a href="#cite_note-pmid9295054-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid9535849_6-0" class="reference"><a href="#cite_note-pmid9535849-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p><p>UGT-1A is a <a href="/w/index.php?title=Uridine_diphosphate_glucuronosyltransferase&action=edit&redlink=1" class="new" title="Uridine diphosphate glucuronosyltransferase (page does not exist)">uridine diphosphate glucuronosyltransferase</a> (UDP-glucuronosyltransferase, UDPGT), an enzyme of the <a href="/wiki/Glucuronidation" title="Glucuronidation">glucuronidation</a> pathway that transforms small <a href="/wiki/Lipophilicity" title="Lipophilicity">lipophilic</a> (fat-soluble) molecules, such as <a href="/wiki/Steroid" title="Steroid">steroids</a>, <a href="/wiki/Bilirubin" title="Bilirubin">bilirubin</a>, <a href="/wiki/Hormone" title="Hormone">hormones</a>, and <a href="/wiki/Drug" title="Drug">drugs</a>, into water-soluble, excretable <a href="/wiki/Metabolite" title="Metabolite">metabolites</a>.<sup id="cite_ref-nlm54658_7-0" class="reference"><a href="#cite_note-nlm54658-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Gene">Gene</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=UDP_glucuronosyltransferase_1_family,_polypeptide_A1&action=edit&section=1" title="Edit section: Gene"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The UGT1A1 gene is part of a complex <a href="/wiki/Locus_(genetics)" title="Locus (genetics)">locus</a> that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternative first <a href="/wiki/Exon" title="Exon">exons</a> followed by four common exons. Four of the alternate first exons are considered <a href="/wiki/Pseudogene" title="Pseudogene">pseudogenes</a>. Each of the remaining nine <a href="/wiki/5%27" class="mw-redirect" title="5'">5'</a> exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own <a href="/wiki/Promotor_(biology)" class="mw-redirect" title="Promotor (biology)">promoter</a>.<sup id="cite_ref-nlm54658_7-1" class="reference"><a href="#cite_note-nlm54658-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> Over 100 <a href="/wiki/Mutation" title="Mutation">genetic variants</a> within the UGT1A1 gene have been described, some of which confer increased, reduced or inactive enzymatic activity. The <a rel="nofollow" class="external text" href="https://web.archive.org/web/20140728205109/http://www.pharmacogenomics.pha.ulaval.ca/cms/ugt_alleles/">UGT nomenclature committee</a> has compiled a list of these variants, naming each with a * symbol followed by a number. </p> <div class="mw-heading mw-heading2"><h2 id="Clinical_significance">Clinical significance</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=UDP_glucuronosyltransferase_1_family,_polypeptide_A1&action=edit&section=2" title="Edit section: Clinical significance"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/wiki/Mutation" title="Mutation">Mutations</a> in this gene cause serious problems for bilirubin metabolism; each syndrome can be caused by one or many mutations, so they are differentiated mostly by symptoms and not particular mutations:<sup id="cite_ref-OMIM191740_8-0" class="reference"><a href="#cite_note-OMIM191740-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p> <ul><li><a href="/wiki/Gilbert_syndrome" class="mw-redirect" title="Gilbert syndrome">Gilbert syndrome</a> (GS) can be caused by a variety of genetic changes, but in populations of European and African descent, it is most commonly associated with the <i>UGT1A1</i>*28 <a href="/wiki/Allele" title="Allele">allele</a> (<a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=8175347">rs8175347</a>), a <a href="/wiki/Homozygous" class="mw-redirect" title="Homozygous">homozygous</a> 2-<a href="/wiki/Base_pair" title="Base pair">bp</a> <a href="/wiki/Insertion_(genetics)" title="Insertion (genetics)">insertion</a> (<a href="/wiki/Thymine" title="Thymine">T</a> <a href="/wiki/Adenine" title="Adenine">A</a>) mutation of the <a href="/wiki/TATA_box" title="TATA box">TATA box</a> <a href="/wiki/Promoter_region" class="mw-redirect" title="Promoter region">promoter region</a> of the <a href="/wiki/UGT1A1" class="mw-redirect" title="UGT1A1">UGT1A1</a> gene.<sup id="cite_ref-OMIM191740_8-1" class="reference"><a href="#cite_note-OMIM191740-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-OMIM143500_9-0" class="reference"><a href="#cite_note-OMIM143500-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-PMID_9653159_10-0" class="reference"><a href="#cite_note-PMID_9653159-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> This <a href="/wiki/Polymorphism_(biology)" title="Polymorphism (biology)">polymorphism</a> impairs proper transcription of <i>UGT1A1</i> gene, resulting in decreased <a href="/wiki/Transcription_(genetics)" class="mw-redirect" title="Transcription (genetics)">transcriptional</a> activity of <i>UGT1A1</i> by about 70%; the resulting reduced enzyme activity leads to the <a href="/wiki/Hyperbilirubinemia" class="mw-redirect" title="Hyperbilirubinemia">hyperbilirubinemia</a> characteristic of GS.<sup id="cite_ref-OMIM191740_8-2" class="reference"><a href="#cite_note-OMIM191740-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-OMIM143500_9-1" class="reference"><a href="#cite_note-OMIM143500-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-PMID_12181419_11-0" class="reference"><a href="#cite_note-PMID_12181419-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> The *28 <a href="/wiki/Polymorphism_(biology)" title="Polymorphism (biology)">polymorphism</a> occurs with a frequency of 26-31% in White and 42-56% of African-Americans.<sup id="cite_ref-PMID_24492252_12-0" class="reference"><a href="#cite_note-PMID_24492252-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> About 10-15% of these populations are homozygous for the *28 allele, but only 5% actually develop UGT1A1-associated <a href="/wiki/Hyperbilirubinemia" class="mw-redirect" title="Hyperbilirubinemia">hyperbilirubinemia</a>, so it appears that this mutation alone may be a necessary but not sufficient factor in GS, perhaps acting in combination with other <i>UGT1A1</i> mutation(s) to increase the chances of developing GS.<sup id="cite_ref-OMIM191740_8-3" class="reference"><a href="#cite_note-OMIM191740-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-OMIM143500_9-2" class="reference"><a href="#cite_note-OMIM143500-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> In Asian and Pacific Islander populations, <i>UGT1A1</i>*28 is much less common, occurring at a frequency of approximately 9-16% in Asian populations and 4% of Pacific Islanders.<sup id="cite_ref-PMID_24492252_12-1" class="reference"><a href="#cite_note-PMID_24492252-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-PMID_24204915_13-0" class="reference"><a href="#cite_note-PMID_24204915-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> In these populations, Gilbert's syndrome is more often due to <a href="/wiki/Missense_mutations" class="mw-redirect" title="Missense mutations">missense mutations</a> in the coding region of the gene, such as <i>UGT1A1</i>*6 (<a href="/wiki/Glycine" title="Glycine">glycine</a> to <a href="/wiki/Arginine" title="Arginine">arginine</a> substitution at position 71 (G71R); <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=4148323">rs4148323</a>) <sup id="cite_ref-OMIM191740_8-4" class="reference"><a href="#cite_note-OMIM191740-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-OMIM143500_9-3" class="reference"><a href="#cite_note-OMIM143500-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> A special <a href="/wiki/Phenobarbital" title="Phenobarbital">phenobarbital</a>-responsive <a href="/wiki/Enhancer_(genetics)" title="Enhancer (genetics)">enhancer</a> module NR3 region (gtPBREM NR3) helps to increase UDPGT enzyme production, which would make it conceptually possible to medically control the bilirubin level, although this is rarely necessary, particularly in adults (usually the level of total serum bilirubin in Gilbert syndrome patients vary from 1 to 6 mg/dL).<sup id="cite_ref-OMIM191740_8-5" class="reference"><a href="#cite_note-OMIM191740-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-OMIM143500_9-4" class="reference"><a href="#cite_note-OMIM143500-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Crigler%E2%80%93Najjar_syndrome,_type_I" class="mw-redirect" title="Crigler–Najjar syndrome, type I">Crigler–Najjar syndrome, type I</a> is associated with mutation(s) that result in a complete absence of normal UGT1A1 enzyme, which causes a severe hyperbilirubinemia with levels of total serum bilirubin from 20 to 45 mg/dL. Phenobarbital treatment does not help to lower bilirubin level, because it only increases the amount of mutated UGT1A1 enzyme, which is still unable to catalyze the <a href="/wiki/Glucuronidation" title="Glucuronidation">glucuronidation</a> of bilirubin, which on the other hand makes phenobarbital treatment diagnostically relevant.<sup id="cite_ref-OMIM191740_8-6" class="reference"><a href="#cite_note-OMIM191740-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-OMIM218800_14-0" class="reference"><a href="#cite_note-OMIM218800-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Crigler%E2%80%93Najjar_syndrome,_type_II" class="mw-redirect" title="Crigler–Najjar syndrome, type II">Crigler–Najjar syndrome, type II</a> is associated with other mutation(s) that lead to a reduced activity of the mutated UGT1A1 enzyme, which causes a hyperbilirubinemia with levels of total serum bilirubin from 6 to 20 mg/dL. In this case phenobarbital treatment helps to lower bilirubin lever by more than 30%.<sup id="cite_ref-OMIM191740_8-7" class="reference"><a href="#cite_note-OMIM191740-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-OMIM606785_15-0" class="reference"><a href="#cite_note-OMIM606785-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Hyperbilirubinemia" class="mw-redirect" title="Hyperbilirubinemia">Hyperbilirubinemia</a>, familial transient neonatal (also called <a href="/wiki/Breastfeeding" title="Breastfeeding">breastfeeding</a> <a href="/wiki/Jaundice" title="Jaundice">jaundice</a>) is associated with mutation(s) that alone do not lead to bilirubin level increase in female patients, but their children when breastfed develop from mild to severe hyperbilirubinemia by receiving <a href="/wiki/Steroid" title="Steroid">steroidal</a> substances (with milk) <a href="/wiki/Enzyme_inhibitor" title="Enzyme inhibitor">inhibiting</a> glucuronidation of unconjugated bilirubin that may lead to jaundice and even <a href="/wiki/Kernicterus" title="Kernicterus">kernicterus</a>.<sup id="cite_ref-OMIM191740_8-8" class="reference"><a href="#cite_note-OMIM191740-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-OMIM237900_16-0" class="reference"><a href="#cite_note-OMIM237900-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup></li></ul> <div class="mw-heading mw-heading2"><h2 id="Pharmacogenetics">Pharmacogenetics</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=UDP_glucuronosyltransferase_1_family,_polypeptide_A1&action=edit&section=3" title="Edit section: Pharmacogenetics"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Genetic variations within the <i>UGT1A1</i> gene have also been associated with the development of certain <a href="/wiki/Adverse_drug_reaction" title="Adverse drug reaction">drug toxicities</a>. The <i>UGT1A1</i>*28 <a href="/wiki/Mutation" title="Mutation">variant</a>, the same <a href="/wiki/Allele" title="Allele">allele</a> behind many cases of <a href="/wiki/Gilbert_syndrome" class="mw-redirect" title="Gilbert syndrome">Gilbert syndrome</a>. The <i>UGT1A1*28</i> has been associated with an increased risk for <a href="/wiki/Neutropenia" title="Neutropenia">neutropenia</a> and <a href="/wiki/Diarrhea" title="Diarrhea">Diarrhea</a> in patients receiving the chemotherapeutic drug <a href="/wiki/Irinotecan" title="Irinotecan">irinotecan</a><sup id="cite_ref-pmid20602618_17-0" class="reference"><a href="#cite_note-pmid20602618-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid24492252_18-0" class="reference"><a href="#cite_note-pmid24492252-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> due to the insufficient excrete the active metabolite SN‐38, which primarily undergoes glucuronidation in livers.<sup id="cite_ref-:0_19-0" class="reference"><a href="#cite_note-:0-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> The <a href="/wiki/U.S._Food_and_Drug_Administration" class="mw-redirect" title="U.S. Food and Drug Administration">U.S. Food and Drug Administration</a> recommends on the irinotecan drug label that patients with the *28/*28 <a href="/wiki/Genotype" title="Genotype">genotype</a> receive a lower starting dose of the drug.<sup id="cite_ref-:0_19-1" class="reference"><a href="#cite_note-:0-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-20" class="reference"><a href="#cite_note-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> The *28 <a href="/wiki/Allele" title="Allele">allele</a> has also shown associations with an increased risk for developing <a href="/wiki/Diarrhea" title="Diarrhea">diarrhea</a> in patients receiving <a href="/wiki/Irinotecan" title="Irinotecan">irinotecan</a>.<sup id="cite_ref-pmid20602618_17-1" class="reference"><a href="#cite_note-pmid20602618-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid24492252_18-1" class="reference"><a href="#cite_note-pmid24492252-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> The <i>UGT1A1</i>*6 <a href="/wiki/Mutation" title="Mutation">variant</a>, more common in Asian populations than the *28 <a href="/wiki/Mutation" title="Mutation">variant</a>, has also shown associations with the development of <a href="/wiki/Irinotecan" title="Irinotecan">irinotecan</a> toxicities. Patients who are <a href="/wiki/Heterozygous" class="mw-redirect" title="Heterozygous">heterozygous</a> or <a href="/wiki/Homozygous" class="mw-redirect" title="Homozygous">homozygous</a> for the *6 <a href="/wiki/Allele" title="Allele">allele</a> may have a higher risk for developing <a href="/wiki/Neutropenia" title="Neutropenia">neutropenia</a> and <a href="/wiki/Diarrhea" title="Diarrhea">diarrhea</a> as compared to those with the <i>UGT1A1</i>*1/*1 <a href="/wiki/Genotype" title="Genotype">genotype</a>.<sup id="cite_ref-pmid20602618_17-2" class="reference"><a href="#cite_note-pmid20602618-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid24492252_18-2" class="reference"><a href="#cite_note-pmid24492252-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Interactive_pathway_map">Interactive pathway map</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=UDP_glucuronosyltransferase_1_family,_polypeptide_A1&action=edit&section=4" title="Edit section: Interactive pathway map"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><i>Click on genes, proteins and metabolites below to link to respective articles.</i> <sup id="cite_ref-WikiPathways_21-0" class="reference"><a href="#cite_note-WikiPathways-21"><span class="cite-bracket">[</span>§ 1<span class="cite-bracket">]</span></a></sup> </p> <div style="overflow:auto;"> <div class="thumb tleft"> <div class="thumbinner" style="width: 377px;"> <div class="thumbimage" style="width: 375px; height: 350px; overflow: hidden;"> <div style="position: relative; top: -576.487394957983px; left: -326.240896358543px; width: {{{bSize}}}px"><div class="noresize">[[File:<div class="noresize thumb tnone" style=";"> <div class="thumbinner" style="overflow:hidden;width:771px;"> <div class="thumbimage" style="overflow:hidden; position:relative; background-color:white;"> <div style=";left:0px; top:0px; width:769px; position:absolute;"> <figure class="mw-default-size mw-halign-right noresize" typeof="mw:File"><a href="/wiki/Irinotecan#Interactive_pathway_map" title="Go to pathway article"><img alt="IrinotecanPathway_WP46359" src="//upload.wikimedia.org/wikipedia/commons/e/ec/IrinotecanPathway_WP229.png" decoding="async" width="769" height="905" class="mw-file-element" data-file-width="769" data-file-height="905" usemap="#ImageMap_241d8b96c5c6bf82" /></a><map name="ImageMap_241d8b96c5c6bf82"><area href="/wiki/Carboxylesterase_2" shape="rect" coords="374,349,434,369" alt="go to article" title="go to article" /><area href="/wiki/Carboxylesterase_1" shape="rect" coords="366,307,426,327" alt="go to article" title="go to article" /><area href="/wiki/SN-38" shape="rect" coords="415,125,475,145" alt="go to article" title="go to article" /><area href="/wiki/CYP3A4" shape="rect" coords="136,289,185,309" alt="go to article" title="go to article" /><area href="/wiki/CYP3A5" shape="rect" coords="120,322,171,342" alt="go to article" title="go to article" /><area href="/wiki/Adenomatosis_polyposis_coli" shape="rect" coords="254,223,314,243" alt="go to article" title="go to article" /><area href="/wiki/CYP3A4" shape="rect" coords="204,294,264,314" alt="go to article" title="go to article" /><area href="/wiki/CYP3A5" shape="rect" coords="257,331,317,351" alt="go to article" title="go to article" /><area href="/wiki/CYP3A4" shape="rect" coords="194,364,254,384" alt="go to article" title="go to article" /><area href="/wiki/Carboxylesterase_1" shape="rect" coords="251,459,311,479" alt="go to article" title="go to article" /><area href="/wiki/Carboxylesterase_2" shape="rect" coords="251,479,311,499" alt="go to article" title="go to article" /><area href="/wiki/UGT1A9" shape="rect" coords="531,495,591,515" alt="go to article" title="go to article" /><area href="/wiki/ABCC1" shape="rect" coords="88,579,148,599" alt="go to article" title="go to article" /><area href="/wiki/Multidrug_resistance-associated_protein_2" shape="rect" coords="88,599,148,619" alt="go to article" title="go to article" /><area href="/wiki/SN-38" shape="rect" coords="327,717,387,737" alt="go to article" title="go to article" /><area href="/wiki/Carboxylesterase_1" shape="rect" coords="216,702,276,722" alt="go to article" title="go to article" /><area href="/wiki/Carboxylesterase_2" shape="rect" coords="216,722,276,742" alt="go to article" title="go to article" /><area href="/wiki/ABCC1" shape="rect" coords="352,566,412,586" alt="go to article" title="go to article" /><area href="/wiki/Multidrug_resistance-associated_protein_2" shape="rect" coords="352,586,412,606" alt="go to article" title="go to article" /><area href="/wiki/ABCG2" shape="rect" coords="352,606,412,626" alt="go to article" title="go to article" /><area href="/wiki/UDP_glucuronosyltransferase_1_family,_polypeptide_A1" shape="rect" coords="479,716,528,736" alt="go to article" title="go to article" /><area href="/wiki/UGT1A10" shape="rect" coords="406,716,461,736" alt="go to article" title="go to article" /><area href="/wiki/Carboxylesterase_2" shape="rect" coords="177,126,226,146" alt="go to article" title="go to article" /><area href="/wiki/Carboxylesterase_1" shape="rect" coords="247,126,299,146" alt="go to article" title="go to article" /><area href="/wiki/Butyrylcholinesterase" shape="rect" coords="341,126,388,146" alt="go to article" title="go to article" /><area href="/wiki/Multidrug_resistance-associated_protein_2" shape="rect" coords="551,590,611,610" alt="go to article" title="go to article" /><area href="/wiki/ABCC1" shape="rect" coords="484,183,534,203" alt="go to article" title="go to article" /><area href="/wiki/SN-38" shape="rect" coords="414,404,474,424" alt="go to article" title="go to article" /><area href="/wiki/SLCO1B1" shape="rect" coords="411,181,464,201" alt="go to article" title="go to article" /></map><figcaption></figcaption></figure></div> <div style="text-align:left; background-color:transparent; color:white; line-height:110%;"> <div id="annotation_0x0" style="position:absolute; left:0px; top:0px; line-height:110%;"><span style="background-color:transparent; color:inherit;">[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:494.74789915966403px; top:463.949579831933px; background:transparent; border-top:3px blue solid"></div>]]</span></div> <div id="annotation_0x0" style="position:absolute; left:0px; top:0px; line-height:110%;"><span style="background-color:transparent; color:inherit;">[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:374.3333333333333px; top:354.333333333333px; background:transparent; border-top:3px blue solid"></div>]]</span></div> <div id="annotation_0x0" 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left:0px; top:0px; line-height:110%;"><span style="background-color:transparent; color:inherit;">[[<div style="display:block; width:46.3445378151259px; height:0px; overflow:hidden; position:relative; left:341.2605042016808px; top:130.666666666667px; background:transparent; border-top:3px blue solid"></div>]]</span></div> <div id="annotation_0x0" style="position:absolute; left:0px; top:0px; line-height:110%;"><span style="background-color:transparent; color:inherit;">[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:551.1008403361344px; top:594.717086834733px; background:transparent; border-top:3px blue solid"></div>]]</span></div> <div id="annotation_0x0" style="position:absolute; left:0px; top:0px; line-height:110%;"><span style="background-color:transparent; color:inherit;">[[<div style="display:block; width:49.8263305322132px; height:0px; overflow:hidden; position:relative; left:483.7871148459377px; top:188.3837535014px; background:transparent; border-top:3px blue solid"></div>]]</span></div> <div id="annotation_0x0" style="position:absolute; left:0px; top:0px; line-height:110%;"><span style="background-color:transparent; color:inherit;">[[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; left:414.3333333333333px; top:409.333333333333px; background:transparent; border-top:3px blue solid"></div>]]</span></div> <div id="annotation_0x0" style="position:absolute; left:0px; top:0px; line-height:110%;"><span style="background-color:transparent; color:inherit;">[[<div style="display:block; width:53.6554621848737px; height:0px; overflow:hidden; position:relative; left:410.6302521008398px; top:186.176470588235px; background:transparent; border-top:3px blue solid"></div>]]</span></div> <div id="annotation_0x0" style="position:absolute; left:0px; top:0px; line-height:110%;"><span style="background-color:transparent; color:inherit;">[[<div style="display:block; width:42.2408963585433px; height:12px; overflow:hidden; position:relative; left:479.12044817927165px; top:704.487394957983px; background:transparent; border:4px black solid"></div>]]</span></div> </div> <div style="visibility:hidden"><figure class="mw-default-size mw-halign-right noresize" typeof="mw:File"><a href="/wiki/Irinotecan#Interactive_pathway_map" title="Go to pathway article"><img alt="IrinotecanPathway_WP46359" src="//upload.wikimedia.org/wikipedia/commons/e/ec/IrinotecanPathway_WP229.png" decoding="async" width="769" height="905" class="mw-file-element" data-file-width="769" data-file-height="905" usemap="#ImageMap_241d8b96c5c6bf82" /></a><map name="ImageMap_241d8b96c5c6bf82"><area href="/wiki/Carboxylesterase_2" shape="rect" coords="374,349,434,369" alt="go to article" title="go to article" /><area href="/wiki/Carboxylesterase_1" shape="rect" coords="366,307,426,327" alt="go to article" title="go to article" /><area href="/wiki/SN-38" shape="rect" coords="415,125,475,145" alt="go to article" title="go to article" /><area href="/wiki/CYP3A4" shape="rect" coords="136,289,185,309" alt="go to article" title="go to article" /><area href="/wiki/CYP3A5" shape="rect" coords="120,322,171,342" alt="go to article" title="go to article" /><area href="/wiki/Adenomatosis_polyposis_coli" shape="rect" coords="254,223,314,243" alt="go to article" title="go to article" /><area href="/wiki/CYP3A4" shape="rect" coords="204,294,264,314" alt="go to article" title="go to article" /><area href="/wiki/CYP3A5" shape="rect" coords="257,331,317,351" alt="go to article" title="go to article" /><area href="/wiki/CYP3A4" shape="rect" coords="194,364,254,384" alt="go to article" title="go to article" /><area href="/wiki/Carboxylesterase_1" shape="rect" coords="251,459,311,479" alt="go to article" title="go to article" /><area href="/wiki/Carboxylesterase_2" shape="rect" coords="251,479,311,499" alt="go to article" title="go to article" /><area href="/wiki/UGT1A9" shape="rect" coords="531,495,591,515" alt="go to article" title="go to article" /><area href="/wiki/ABCC1" shape="rect" coords="88,579,148,599" alt="go to article" title="go to article" /><area href="/wiki/Multidrug_resistance-associated_protein_2" shape="rect" coords="88,599,148,619" alt="go to article" title="go to article" /><area href="/wiki/SN-38" shape="rect" coords="327,717,387,737" alt="go to article" title="go to article" /><area href="/wiki/Carboxylesterase_1" shape="rect" coords="216,702,276,722" alt="go to article" title="go to article" /><area href="/wiki/Carboxylesterase_2" shape="rect" coords="216,722,276,742" alt="go to article" title="go to article" /><area href="/wiki/ABCC1" shape="rect" coords="352,566,412,586" alt="go to article" title="go to article" /><area href="/wiki/Multidrug_resistance-associated_protein_2" shape="rect" coords="352,586,412,606" alt="go to article" title="go to article" /><area href="/wiki/ABCG2" shape="rect" coords="352,606,412,626" alt="go to article" title="go to article" /><area href="/wiki/UDP_glucuronosyltransferase_1_family,_polypeptide_A1" shape="rect" coords="479,716,528,736" alt="go to article" title="go to article" /><area href="/wiki/UGT1A10" shape="rect" coords="406,716,461,736" alt="go to article" title="go to article" /><area href="/wiki/Carboxylesterase_2" shape="rect" coords="177,126,226,146" alt="go to article" title="go to article" /><area href="/wiki/Carboxylesterase_1" shape="rect" coords="247,126,299,146" alt="go to article" title="go to article" /><area href="/wiki/Butyrylcholinesterase" shape="rect" coords="341,126,388,146" alt="go to article" title="go to article" /><area href="/wiki/Multidrug_resistance-associated_protein_2" shape="rect" coords="551,590,611,610" alt="go to article" title="go to article" /><area href="/wiki/ABCC1" shape="rect" coords="484,183,534,203" alt="go to article" title="go to article" /><area href="/wiki/SN-38" shape="rect" coords="414,404,474,424" alt="go to article" title="go to article" /><area href="/wiki/SLCO1B1" shape="rect" coords="411,181,464,201" alt="go to article" title="go to article" /></map><figcaption></figcaption></figure></div> </div> <div class="thumbcaption"></div> </div></div>|alt=Irinotecan Pathway <a rel="nofollow" class="external text" href="http://www.wikipathways.org/index.php/Pathway:WP46359">edit</a>]]</div></div> </div> <div class="thumbcaption"> <div class="magnify"><a href="/wiki/File:IrinotecanPathway_WP229.png" title="File:IrinotecanPathway WP229.png"> </a></div>Irinotecan Pathway <a rel="nofollow" class="external text" href="http://www.wikipathways.org/index.php/Pathway:WP46359">edit</a> </div> </div> </div> <div style="clear:both;" class=""></div><style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist 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<style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px 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.cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.wikipathways.org/index.php/Pathway:WP229">"IrinotecanPathway_WP229"</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=IrinotecanPathway_WP229&rft_id=http%3A%2F%2Fwww.wikipathways.org%2Findex.php%2FPathway%3AWP229&rfr_id=info%3Asid%2Fen.wikipedia.org%3AUDP+glucuronosyltransferase+1+family%2C+polypeptide+A1" class="Z3988"></span></span> </li> </ol></div></div> </div> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=UDP_glucuronosyltransferase_1_family,_polypeptide_A1&action=edit&section=5" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Glucuronosyltransferase" title="Glucuronosyltransferase">Glucuronosyltransferase</a></li> <li><a href="/wiki/Lucey-Driscoll_syndrome" class="mw-redirect" title="Lucey-Driscoll syndrome">Lucey-Driscoll syndrome</a></li> <li><a href="/wiki/Neonatal_jaundice" title="Neonatal jaundice">Neonatal jaundice</a></li> <li><a href="/wiki/Cancer_pharmacogenomics" title="Cancer pharmacogenomics">Cancer pharmacogenomics</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=UDP_glucuronosyltransferase_1_family,_polypeptide_A1&action=edit&section=6" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239543626"><div class="reflist reflist-columns references-column-width" style="column-width: 35em;"> <ol class="references"> <li id="cite_note-refGRCh38Ensembl-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCh38Ensembl_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000241635">GRCh38: Ensembl release 89: ENSG00000241635</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-refGRCm38Ensembl-2"><span class="mw-cite-backlink">^ <a 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UGT1A1 - 191740</a></span> </li> <li id="cite_note-OMIM143500-9"><span class="mw-cite-backlink">^ <a href="#cite_ref-OMIM143500_9-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-OMIM143500_9-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-OMIM143500_9-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-OMIM143500_9-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-OMIM143500_9-4"><sup><i><b>e</b></i></sup></a></span> <span class="reference-text"><a href="/wiki/Online_Mendelian_Inheritance_in_Man" title="Online Mendelian Inheritance in Man">Online Mendelian Inheritance in Man</a> (OMIM): <a rel="nofollow" class="external text" href="https://omim.org/entry/143500">Gilbert syndrome - 143500</a></span> </li> <li id="cite_note-PMID_9653159-10"><span class="mw-cite-backlink"><b><a href="#cite_ref-PMID_9653159_10-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBeutlerGelbartDemina1998" class="citation journal cs1">Beutler E, Gelbart T, Demina A (July 1998). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC20948">"Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism?"</a>. <i>Proc Natl Acad Sci USA</i>. <b>95</b> (14): 8170–4. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1998PNAS...95.8170B">1998PNAS...95.8170B</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1073%2Fpnas.95.14.8170">10.1073/pnas.95.14.8170</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC20948">20948</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9653159">9653159</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Proc+Natl+Acad+Sci+USA&rft.atitle=Racial+variability+in+the+UDP-glucuronosyltransferase+1+%28UGT1A1%29+promoter%3A+a+balanced+polymorphism+for+regulation+of+bilirubin+metabolism%3F&rft.volume=95&rft.issue=14&rft.pages=8170-4&rft.date=1998-07&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC20948%23id-name%3DPMC&rft_id=info%3Apmid%2F9653159&rft_id=info%3Adoi%2F10.1073%2Fpnas.95.14.8170&rft_id=info%3Abibcode%2F1998PNAS...95.8170B&rft.aulast=Beutler&rft.aufirst=E&rft.au=Gelbart%2C+T&rft.au=Demina%2C+A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC20948&rfr_id=info%3Asid%2Fen.wikipedia.org%3AUDP+glucuronosyltransferase+1+family%2C+polypeptide+A1" class="Z3988"></span></span> </li> <li id="cite_note-PMID_12181419-11"><span class="mw-cite-backlink"><b><a href="#cite_ref-PMID_12181419_11-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFTukeyStrassburgMackenzie2002" class="citation journal cs1">Tukey RH, Strassburg CP, Mackenzie PI (September 2002). 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id="cite_note-20"><span class="mw-cite-backlink"><b><a href="#cite_ref-20">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e518dfc6-7e93-4fee-a66c-51e1ab71c056">"CAMPTOSAR (irinotecan hydrochloride injection, solution) drug label"</a>. <i>DailyMed</i>. U.S. National Library of Medicine<span class="reference-accessdate">. Retrieved <span class="nowrap">5 January</span> 2015</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=DailyMed&rft.atitle=CAMPTOSAR+%28irinotecan+hydrochloride+injection%2C+solution%29+drug+label&rft_id=http%3A%2F%2Fdailymed.nlm.nih.gov%2Fdailymed%2FdrugInfo.cfm%3Fsetid%3De518dfc6-7e93-4fee-a66c-51e1ab71c056&rfr_id=info%3Asid%2Fen.wikipedia.org%3AUDP+glucuronosyltransferase+1+family%2C+polypeptide+A1" class="Z3988"></span></span> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=UDP_glucuronosyltransferase_1_family,_polypeptide_A1&action=edit&section=7" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin refbegin-columns references-column-width" style="column-width: 35em"> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFTukeyStrassburg2000" class="citation journal cs1">Tukey RH, Strassburg CP (2000). 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title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cancer+Prev.+Res.&rft.atitle=Cruciferous+vegetable+feeding+alters+UGT1A1+activity%3A+diet+and+genotype-dependent+changes+in+serum+bilirubin+in+a+controlled+trial.&rft.volume=2&rft.issue=4&rft.pages=345-52&rft.date=2009&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2666928%23id-name%3DPMC&rft_id=info%3Apmid%2F19336732&rft_id=info%3Adoi%2F10.1158%2F1940-6207.CAPR-08-0178&rft.aulast=Navarro&rft.aufirst=SL&rft.au=Peterson%2C+S&rft.au=Chen%2C+C&rft.au=Makar%2C+KW&rft.au=Schwarz%2C+Y&rft.au=King%2C+IB&rft.au=Li%2C+SS&rft.au=Li%2C+L&rft.au=Kestin%2C+M&rft.au=Lampe%2C+JW&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2666928&rfr_id=info%3Asid%2Fen.wikipedia.org%3AUDP+glucuronosyltransferase+1+family%2C+polypeptide+A1" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBarbarinoHaidarKleinAltman2014" class="citation journal cs1">Barbarino JM, Haidar CE, Klein TE, Altman RB (March 2014). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091838">"PharmGKB summary: very important pharmacogene information for UGT1A1"</a>. <i>Pharmacogenet Genomics</i>. <b>24</b> (3): 177–83. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1097%2FFPC.0000000000000024">10.1097/FPC.0000000000000024</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091838">4091838</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/24492252">24492252</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Pharmacogenet+Genomics&rft.atitle=PharmGKB+summary%3A+very+important+pharmacogene+information+for+UGT1A1&rft.volume=24&rft.issue=3&rft.pages=177-83&rft.date=2014-03&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4091838%23id-name%3DPMC&rft_id=info%3Apmid%2F24492252&rft_id=info%3Adoi%2F10.1097%2FFPC.0000000000000024&rft.aulast=Barbarino&rft.aufirst=JM&rft.au=Haidar%2C+CE&rft.au=Klein%2C+TE&rft.au=Altman%2C+RB&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4091838&rfr_id=info%3Asid%2Fen.wikipedia.org%3AUDP+glucuronosyltransferase+1+family%2C+polypeptide+A1" class="Z3988"></span></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=UDP_glucuronosyltransferase_1_family,_polypeptide_A1&action=edit&section=8" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?name=UGT1A1+protein%2C+human">UGT1A1+protein,+human</a> at the U.S. National Library of Medicine <a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">Medical Subject Headings</a> (MeSH)</li> <li><a rel="nofollow" class="external text" href="https://web.archive.org/web/20140728205109/http://www.pharmacogenomics.pha.ulaval.ca/cms/ugt_alleles/">UGT nomenclature homepage</a></li> <li><a rel="nofollow" class="external text" href="https://www.pharmgkb.org/gene/PA420">PharmGKB page for UGT1A1</a></li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist 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.navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Glycosyltransferases" title="Template:Glycosyltransferases"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Glycosyltransferases" title="Template talk:Glycosyltransferases"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Glycosyltransferases" title="Special:EditPage/Template:Glycosyltransferases"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Transferases:_glycosyltransferases_(EC_2.4)" style="font-size:114%;margin:0 4em"><a href="/wiki/Transferase" title="Transferase">Transferases</a>: <a href="/wiki/Glycosyltransferase" title="Glycosyltransferase">glycosyltransferases</a> (<a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC</a> 2.4)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_2)#EC_2.4.1:_Hexosyltransferases" title="List of EC numbers (EC 2)">2.4.1</a>: <a href="/wiki/Hexosyltransferase" title="Hexosyltransferase">Hexosyl-<br />transferases</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Glucosyltransferase" title="Glucosyltransferase">Glucosyl-</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Phosphorylase" title="Phosphorylase">Phosphorylase</a> <ul><li><a href="/wiki/Starch_phosphorylase" title="Starch phosphorylase">Starch</a></li> <li><a href="/wiki/Glycogen_phosphorylase" title="Glycogen phosphorylase">Glycogen</a></li> <li><a href="/wiki/Cellobiose_phosphorylase" title="Cellobiose phosphorylase">Cellobiose</a></li> <li><a href="/wiki/Myophosphorylase" title="Myophosphorylase">Myo-</a></li></ul></li> <li><a href="/wiki/Glycogen_synthase" title="Glycogen synthase">Glycogen synthase</a></li> <li><a href="/wiki/Glycogen_debranching_enzyme" title="Glycogen debranching enzyme">Debranching enzyme</a></li> <li><a href="/wiki/Glycogen_branching_enzyme" title="Glycogen branching enzyme">Branching enzyme</a></li> <li><a href="/wiki/1,3-Beta-glucan_synthase" title="1,3-Beta-glucan synthase">1,3-Beta-glucan synthase</a></li> <li><a href="/wiki/Ceramide_glucosyltransferase" title="Ceramide glucosyltransferase">Ceramide glucosyltransferase</a></li> <li><a href="/wiki/N-glycosyltransferase" title="N-glycosyltransferase">N-glycosyltransferase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Galactosyltransferase" title="Galactosyltransferase">Galactosyl-</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Lactose_synthase" title="Lactose synthase">Lactose synthase</a></li> <li><a href="/wiki/B-N-acetylglucosaminyl-glycopeptide_b-1,4-galactosyltransferase" title="B-N-acetylglucosaminyl-glycopeptide b-1,4-galactosyltransferase">B-N-acetylglucosaminyl-glycopeptide b-1,4-galactosyltransferase</a></li> <li><a href="/wiki/Glycoprotein-N-acetylgalactosamine_3-beta-galactosyltransferase" title="Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase">Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase</a> (<a href="/wiki/C1GALT1" title="C1GALT1">C1GALT1</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Glucuronosyltransferase" title="Glucuronosyltransferase">Glucuronosyl-</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/B3GAT1" title="B3GAT1">B3GAT1</a></li> <li><a href="/wiki/B3GAT2" title="B3GAT2">B3GAT2</a></li> <li><a href="/wiki/B3GAT3" title="B3GAT3">B3GAT3</a></li></ul> <ul><li><a class="mw-selflink selflink">UGT1A1</a></li> <li><a href="/wiki/UGT1A3" title="UGT1A3">UGT1A3</a></li> <li><a href="/wiki/UGT1A4" title="UGT1A4">UGT1A4</a></li> <li><a href="/wiki/UGT1A5" title="UGT1A5">UGT1A5</a></li> <li><a href="/wiki/UGT1A6" title="UGT1A6">UGT1A6</a></li> <li><a href="/wiki/UGT1A7" class="mw-redirect" title="UGT1A7">UGT1A7</a></li> <li><a href="/wiki/UGT1A8" title="UGT1A8">UGT1A8</a></li> <li><a href="/wiki/UGT1A9" title="UGT1A9">UGT1A9</a></li> <li><a href="/wiki/UGT1A10" title="UGT1A10">UGT1A10</a></li></ul> <ul><li><a href="/wiki/UGT2A1" title="UGT2A1">UGT2A1</a></li> <li><a href="/wiki/UGT2A2" title="UGT2A2">UGT2A2</a></li> <li><a href="/wiki/UGT2A3" class="mw-redirect" title="UGT2A3">UGT2A3</a></li> <li><a href="/wiki/UGT2B4" title="UGT2B4">UGT2B4</a></li> <li><a href="/wiki/UGT2B7" title="UGT2B7">UGT2B7</a></li> <li><a href="/wiki/UGT2B10" title="UGT2B10">UGT2B10</a></li> <li><a href="/wiki/UGT2B11" class="mw-redirect" title="UGT2B11">UGT2B11</a></li> <li><a href="/wiki/UGT2B15" title="UGT2B15">UGT2B15</a></li> <li><a href="/wiki/UGT2B17" title="UGT2B17">UGT2B17</a></li> <li><a href="/wiki/UGT2B28" class="mw-redirect" title="UGT2B28">UGT2B28</a></li></ul> <ul><li><a href="/wiki/Hyaluronan_synthase" title="Hyaluronan synthase">Hyaluronan synthase</a>: <a href="/wiki/HAS1" title="HAS1">HAS1</a></li> <li><a href="/wiki/HAS2" title="HAS2">HAS2</a></li> <li><a href="/wiki/HAS3" title="HAS3">HAS3</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Fucosyltransferase" title="Fucosyltransferase">Fucosyl-</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/GDP-fucose_protein_O-fucosyltransferase_1" title="GDP-fucose protein O-fucosyltransferase 1">POFUT1</a></li> <li><a href="/wiki/GDP-fucose_protein_O-fucosyltransferase_2" title="GDP-fucose protein O-fucosyltransferase 2">POFUT2</a></li> <li><a href="/wiki/FUT1" title="FUT1">FUT1</a></li> <li><a href="/wiki/FUT2" title="FUT2">FUT2</a></li> <li><a href="/wiki/Fucosyltransferase_3" title="Fucosyltransferase 3">FUT3</a></li> <li><a href="/wiki/FUT4" title="FUT4">FUT4</a></li> <li><a href="/wiki/FUT5" title="FUT5">FUT5</a></li> <li><a href="/wiki/FUT6" title="FUT6">FUT6</a></li> <li><a href="/wiki/FUT7" title="FUT7">FUT7</a></li> <li><a href="/wiki/FUT8" title="FUT8">FUT8</a></li> <li><a href="/wiki/FUT9" title="FUT9">FUT9</a></li> <li><a href="/w/index.php?title=FUT10&action=edit&redlink=1" class="new" title="FUT10 (page does not exist)">FUT10</a></li> <li><a href="/w/index.php?title=FUT11&action=edit&redlink=1" class="new" title="FUT11 (page does not exist)">FUT11</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Mannosyltransferase" title="Mannosyltransferase">Mannosyl-</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Dolichyl-phosphate-mannose-protein_mannosyltransferase" title="Dolichyl-phosphate-mannose-protein mannosyltransferase">Dolichyl-phosphate-mannose-protein mannosyltransferase</a> <ul><li><a href="/wiki/POMT1" title="POMT1">POMT1</a></li> <li><a href="/wiki/POMT2" title="POMT2">POMT2</a></li></ul></li> <li><a href="/wiki/DPM1" title="DPM1">DPM1</a></li> <li><a href="/wiki/DPM3" title="DPM3">DPM3</a></li></ul> <ul><li><a href="/wiki/ALG1" title="ALG1">ALG1</a></li> <li><a href="/wiki/ALG2" title="ALG2">ALG2</a></li> <li><a href="/wiki/ALG3" title="ALG3">ALG3</a></li> <li><a href="/wiki/ALG6" title="ALG6">ALG6</a></li> <li><a href="/wiki/ALG8" title="ALG8">ALG8</a></li> <li><a href="/wiki/ALG9" title="ALG9">ALG9</a></li> <li><a href="/wiki/ALG12" title="ALG12">ALG12</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_2)#EC_2.4.2:_Pentosyltransferases" title="List of EC numbers (EC 2)">2.4.2</a>: <a href="/wiki/Pentosyltransferase" title="Pentosyltransferase">Pentosyl-<br />transferases</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="Ribose" scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Ribose" title="Ribose">Ribose</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/ADP-ribosylation" title="ADP-ribosylation">ADP-ribosyltransferase</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/NAD(%2B)%E2%80%94diphthamide_ADP-ribosyltransferase" title="NAD(+)—diphthamide ADP-ribosyltransferase">NAD<sup>+</sup>:diphthamide ADP-ribosyltransferase</a> <ul><li><a href="/wiki/Diphtheria_toxin" title="Diphtheria toxin">Diphtheria toxin</a></li> <li><a href="/wiki/Pseudomonas_exotoxin" title="Pseudomonas exotoxin">Pseudomonas exotoxin</a></li></ul></li></ul> <ul><li><a href="/wiki/NAD(P)(%2B)%E2%80%94protein-arginine_ADP-ribosyltransferase" title="NAD(P)(+)—protein-arginine ADP-ribosyltransferase">NAD(P)<sup>+</sup>:arginine ADP-ribosyltransferase</a> <ul><li><a href="/wiki/Pertussis_toxin" title="Pertussis toxin">Pertussis toxin</a></li> <li><a href="/wiki/Cholera_toxin" title="Cholera toxin">Cholera toxin</a></li></ul></li></ul> <ul><li><a href="/wiki/Poly_ADP_ribose_polymerase" class="mw-redirect" title="Poly ADP ribose polymerase">Poly ADP ribose polymerase</a></li></ul> <ul><li><a href="/wiki/Sirtuin" title="Sirtuin">Sirtuin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Phosphoribosyltransferase" title="Phosphoribosyltransferase">Phosphoribosyltransferase</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Adenine_phosphoribosyltransferase" title="Adenine phosphoribosyltransferase">Adenine phosphoribosyltransferase</a></li> <li><a href="/wiki/Hypoxanthine-guanine_phosphoribosyltransferase" title="Hypoxanthine-guanine phosphoribosyltransferase">Hypoxanthine-guanine phosphoribosyltransferase</a></li> <li><a href="/wiki/Uracil_phosphoribosyltransferase" title="Uracil phosphoribosyltransferase">Uracil phosphoribosyltransferase</a></li> <li><a href="/wiki/Amidophosphoribosyltransferase" title="Amidophosphoribosyltransferase">Amidophosphoribosyltransferase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Purine_nucleoside_phosphorylase" title="Purine nucleoside phosphorylase">Purine nucleoside phosphorylase</a>: <a href="/wiki/Thymidine_phosphorylase" title="Thymidine phosphorylase">Thymidine phosphorylase</a> <ul><li><a href="/wiki/ECGF1" class="mw-redirect" title="ECGF1">ECGF1</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Xylosyltransferase" title="Xylosyltransferase">Xylosyltransferase</a> <ul><li><a href="/wiki/XYLT1" title="XYLT1">XYLT1</a></li> <li><a href="/wiki/XYLT2" title="XYLT2">XYLT2</a></li></ul></li> <li><a href="/wiki/Arabinosyltransferase" title="Arabinosyltransferase">Arabinosyltransferase</a> <ul><li><a href="/wiki/Indolylacetylinositol_arabinosyltransferase" title="Indolylacetylinositol arabinosyltransferase">Indolylacetylinositol arabinosyltransferase</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_2)#EC_2.4.99:_Transferring_Other_Glycosyl_Groups" title="List of EC numbers (EC 2)">2.4.99</a>: <a href="/wiki/Sialyltransferase" title="Sialyltransferase">Sialyl<br />transferases</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Beta-galactoside_alpha-2,6-sialyltransferase" title="Beta-galactoside alpha-2,6-sialyltransferase">Beta-galactoside alpha-2,6-sialyltransferase</a></li> <li><a href="/wiki/Monosialoganglioside_sialyltransferase" title="Monosialoganglioside sialyltransferase">Monosialoganglioside sialyltransferase</a></li> <li><a href="/wiki/ST8SIA4" title="ST8SIA4">ST8SIA4</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Enzymes" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li 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href="/wiki/Oxyanion_hole" title="Oxyanion hole">Oxyanion hole</a></li> <li><a href="/wiki/Enzyme_promiscuity" title="Enzyme promiscuity">Enzyme promiscuity</a></li> <li><a href="/wiki/Diffusion-limited_enzyme" title="Diffusion-limited enzyme">Diffusion-limited enzyme</a></li> <li><a href="/wiki/Cofactor_(biochemistry)" title="Cofactor (biochemistry)">Cofactor</a></li> <li><a href="/wiki/Enzyme_catalysis" title="Enzyme catalysis">Enzyme catalysis</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Regulation</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Allosteric_regulation" title="Allosteric regulation">Allosteric regulation</a></li> <li><a href="/wiki/Cooperativity" title="Cooperativity">Cooperativity</a></li> <li><a href="/wiki/Enzyme_inhibitor" title="Enzyme inhibitor">Enzyme inhibitor</a></li> <li><a href="/wiki/Enzyme_activator" title="Enzyme activator">Enzyme activator</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Classification</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC number</a></li> <li><a href="/wiki/Protein_superfamily" title="Protein superfamily">Enzyme superfamily</a></li> <li><a href="/wiki/Protein_family" title="Protein family">Enzyme family</a></li> <li><a href="/wiki/List_of_enzymes" title="List of enzymes">List of enzymes</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Kinetics</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Enzyme_kinetics" title="Enzyme kinetics">Enzyme kinetics</a></li> <li><a href="/wiki/Eadie%E2%80%93Hofstee_diagram" title="Eadie–Hofstee diagram">Eadie–Hofstee diagram</a></li> <li><a href="/wiki/Hanes%E2%80%93Woolf_plot" title="Hanes–Woolf plot">Hanes–Woolf plot</a></li> <li><a href="/wiki/Lineweaver%E2%80%93Burk_plot" title="Lineweaver–Burk plot">Lineweaver–Burk plot</a></li> <li><a href="/wiki/Michaelis%E2%80%93Menten_kinetics" title="Michaelis–Menten kinetics">Michaelis–Menten kinetics</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Types</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><b>EC1 <a href="/wiki/Oxidoreductase" title="Oxidoreductase">Oxidoreductases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_1)" title="List of EC numbers (EC 1)">list</a>)</li> <li><b>EC2 <a href="/wiki/Transferase" title="Transferase">Transferases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_2)" title="List of EC numbers (EC 2)">list</a>)</li> <li><b>EC3 <a href="/wiki/Hydrolase" title="Hydrolase">Hydrolases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_3)" title="List of EC numbers (EC 3)">list</a>)</li> <li><b>EC4 <a href="/wiki/Lyase" title="Lyase">Lyases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_4)" title="List of EC numbers (EC 4)">list</a>)</li> <li><b>EC5 <a href="/wiki/Isomerase" title="Isomerase">Isomerases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_5)" title="List of EC numbers (EC 5)">list</a>)</li> <li><b>EC6 <a href="/wiki/Ligase" title="Ligase">Ligases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_6)" title="List of EC numbers (EC 6)">list</a>)</li> <li><b>EC7 <a href="/wiki/Translocase" title="Translocase">Translocases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_7)" title="List of EC numbers (EC 7)">list</a>)</li></ul> </div></td></tr></tbody></table></div> <style data-mw-deduplicate="TemplateStyles:r1130092004">.mw-parser-output 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href="/wiki/Wikipedia:Contents/Portals" title="Wikipedia:Contents/Portals">Portal</a>:</span><ul class="portal-bar-content"><li class="portal-bar-item"><span class="nowrap"><span typeof="mw:File"><a href="/wiki/File:Issoria_lathonia.jpg" class="mw-file-description"><img alt="icon" src="//upload.wikimedia.org/wikipedia/commons/thumb/2/2d/Issoria_lathonia.jpg/21px-Issoria_lathonia.jpg" decoding="async" width="21" height="15" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/2d/Issoria_lathonia.jpg/32px-Issoria_lathonia.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/2d/Issoria_lathonia.jpg/42px-Issoria_lathonia.jpg 2x" data-file-width="629" data-file-height="445" /></a></span> </span><a href="/wiki/Portal:Biology" title="Portal:Biology">Biology</a></li></ul></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Enzymes_involved_in_the_metabolism_of_heme_and_porphyrin" style="padding:3px"><table class="nowraplinks hlist mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Porphyrin_metabolism_enzymes" title="Template:Porphyrin metabolism enzymes"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Porphyrin_metabolism_enzymes" title="Template talk:Porphyrin metabolism enzymes"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Porphyrin_metabolism_enzymes" title="Special:EditPage/Template:Porphyrin metabolism enzymes"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Enzymes_involved_in_the_metabolism_of_heme_and_porphyrin" style="font-size:114%;margin:0 4em"><a href="/wiki/Enzyme" title="Enzyme">Enzymes</a> involved in the <a href="/wiki/Protein_metabolism" title="Protein metabolism">metabolism</a> of <a href="/wiki/Heme" title="Heme">heme</a> and <a href="/wiki/Porphyrin" title="Porphyrin">porphyrin</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Porphyrin#Biosynthesis" title="Porphyrin">Porphyrin biosynthesis</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>early mitochondrial:</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Aminolevulinic_acid_synthase" title="Aminolevulinic acid synthase">Aminolevulinic acid synthase</a> <ul><li><a href="/wiki/ALAS1" title="ALAS1">ALAS1</a></li> <li><a href="/wiki/ALAS2" title="ALAS2">ALAS2</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>cytosolic:</i></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Porphobilinogen_synthase" class="mw-redirect" title="Porphobilinogen synthase">Porphobilinogen synthase</a></li> <li><a href="/wiki/Porphobilinogen_deaminase" title="Porphobilinogen deaminase">Porphobilinogen deaminase</a></li> <li><a href="/wiki/Uroporphyrinogen_III_synthase" title="Uroporphyrinogen III synthase">Uroporphyrinogen III synthase</a></li> <li><a href="/wiki/Uroporphyrinogen_III_decarboxylase" title="Uroporphyrinogen III decarboxylase">Uroporphyrinogen III decarboxylase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>late mitochondrial:</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Coproporphyrinogen_III_oxidase" title="Coproporphyrinogen III oxidase">Coproporphyrinogen III oxidase</a></li> <li><a href="/wiki/Protoporphyrinogen_oxidase" title="Protoporphyrinogen oxidase">Protoporphyrinogen oxidase</a></li> <li><a href="/wiki/Ferrochelatase" title="Ferrochelatase">Ferrochelatase</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Heme#Degradation" title="Heme">Heme degradation</a><br />to <a href="/wiki/Bile" title="Bile">bile</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>spleen:</i></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Heme_oxygenase" title="Heme oxygenase">Heme oxygenase</a></li> <li><a href="/wiki/Biliverdin_reductase" title="Biliverdin reductase">Biliverdin reductase</a><br /></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>liver:</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Glucuronosyltransferase" title="Glucuronosyltransferase">glucuronosyltransferase</a></i> <ul><li><a class="mw-selflink selflink">UGT1A1</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?useformat=desktop&type=1x1&usesul3=0" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" href="https://en.wikipedia.org/w/index.php?title=UDP_glucuronosyltransferase_1_family,_polypeptide_A1&oldid=1185015979">https://en.wikipedia.org/w/index.php?title=UDP_glucuronosyltransferase_1_family,_polypeptide_A1&oldid=1185015979</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Help:Category" title="Help:Category">Categories</a>: <ul><li><a href="/wiki/Category:Genes_on_human_chromosome_2" title="Category:Genes on human chromosome 2">Genes on human chromosome 2</a></li><li><a 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