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Reliability and changes in knee cartilage T2 relaxation time from 6 to 24 months after anatomic anterior cruciate ligament reconstruction. <em class='incite-journal-name' onclick='ShowInCiteJournal(14817);'>J Orthop Res</em> 2024;<b>42</b>:2683-2692. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39032093' target='_blank'>39032093</a> DOI: <a href='https://dx.doi.org/10.1002/jor.25939' target='_blank'>10.1002/jor.25939</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/jor.25939','39032093', 'cartilage degeneration')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(1);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(1);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(1);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(1);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1002/jor.25939' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(14817);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://mc.manuscriptcentral.com/jores?3' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/22/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv1" value="10.1002/jor.25939" /> <div style="display: none" id="articleAbstract1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The objectives of this study were to evaluate the reliability of cartilage T2 relaxation time measurements and to identify focal changes in T2 relaxation on the affected knee from 6 to 24 months after anatomic anterior cruciate ligament reconstruction (ACLR). Data from 41 patients who received anatomic ACLR were analyzed. A bilateral 3.0-T MRI was acquired 6 and 24 months after ACLR. T2 relaxation time was measured in subregions of the femoral condyle and the tibial plateau. The root-mean-square coefficient of variation (RMSCV) was calculated to evaluate the reliability of T2 relaxation time in the contralateral knee. Subregion changes in the affected knee T2 relaxation time were identified using the contralateral knee as a reference. The superficial and full thickness layers of the central and inner regions showed good reliability. Conversely, the outer regions on the femoral side and regions in the deep layers showed poor reliability. T2 relaxation time increased in only 3 regions on the affected knee when controlling for changes in the contralateral knee, while changes in T2 relaxation time were identified in 14 regions when not using the contralateral knee as a reference. In conclusion, evaluation of cartilage degeneration by T2 relaxation time after ACLR is most reliable for central and inner cartilage regions. Cartilage degeneration occurs in the central and outer regions of the lateral femoral condyle from 6 to 24 months after anatomic ACLR. </div> <a href="javascript:ShowArticleAbstract(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22T2+relaxation+time%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">T2 relaxation time</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22anterior+cruciate+ligament+reconstruction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">anterior cruciate ligament reconstruction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cartilage+degeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cartilage degeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22reliability%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">reliability</a></li></ul> <a href="javascript:ShowArticleKeywords(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anterior+Cruciate+Ligament+Reconstruction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anterior Cruciate Ligament Reconstruction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Magnetic+Resonance+Imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Magnetic Resonance Imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Young+Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Young Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cartilage%2c+Articular%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cartilage, Articular/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Knee+Joint%2fdiagnostic+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Knee Joint/diagnostic imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reproducibility+of+Results%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reproducibility of Results</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adolescent%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adolescent</a></li></ul> <a href="javascript:ShowArticleMeSH(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIAMS+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">1R01 AR056630-01A2 NIAMS NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIAMS+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">1R01 AR056630-01A2 NIAMS NIH HHS</a></li></ul> <a href="javascript:ShowArticleGrant(1);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow2"> <td style="min-width: 40px; text-align: center;"> 2 </td> <td> <div id="citation2" class="article-citation"> <b>Zou X</b>, Xu H, Qian W. The role and current research status of resveratrol in the treatment of osteoarthritis and its mechanisms: a narrative review. <em class='incite-journal-name' onclick='ShowInCiteJournal(8201);'>Drug Metab Rev</em> 2024:1-14. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39376171' target='_blank'>39376171</a> DOI: <a href='https://dx.doi.org/10.1080/03602532.2024.2402751' target='_blank'>10.1080/03602532.2024.2402751</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1080/03602532.2024.2402751','39376171', 'cartilage degeneration')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(2);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(2);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1080/03602532.2024.2402751' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(8201);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/04/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/09/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv2" value="10.1080/03602532.2024.2402751" /> <div style="display: none" id="articleAbstract2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Osteoarthritis (OA) is a chronic degenerative disease caused by various factors such as aging, obesity, trauma, and genetics. It is a challenging condition faced by orthopedic doctors in clinical practice and places a heavy burden on patients and their families. Currently, the treatment of OA primarily focuses on symptomatic relief and lacks ideal therapeutic methods. Resveratrol is a natural polyphenolic compound with anti-inflammatory and antioxidant properties, and in recent years, it has gained attention as a candidate drug for OA treatment. This article provides an overview of the research status on the role and mechanisms of resveratrol in treating OA. It has been found that resveratrol can prevent the development of OA by inhibiting inflammatory responses, protecting chondrocytes, maintaining cartilage homeostasis, promoting autophagy, and has shown certain therapeutic effects. This process may be related to the regulation of signaling pathways such as nuclear factor-kappa B (NF-κB), Toll-like receptor 4 (TLR4), and silent information regulator 1 (SIRT1). We summarize the current molecular mechanisms of resveratrol in treating OA, hoping to provide a reference for further research and application of resveratrol in OA treatment. </div> <a href="javascript:ShowArticleAbstract(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Resveratrol%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Resveratrol</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cartilage+degeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cartilage degeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cell+apoptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cell apoptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22osteoarthritis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">osteoarthritis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22signaling+pathways%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">signaling pathways</a></li></ul> <a href="javascript:ShowArticleKeywords(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(2);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow3"> <td style="min-width: 40px; text-align: center;"> 3 </td> <td> <div id="citation3" class="article-citation"> <b>Khaleque MA</b>, Kim JH, Tanvir MAH, Park JB, Kim YY. Significance of Necroptosis in <span class="highlight-field">Cartilage Degeneration</span>. <em class='incite-journal-name' onclick='ShowInCiteJournal(3676);'>Biomolecules</em> 2024;<b>14</b>:1192. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39334958' target='_blank'>39334958</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11429838' target='_blank'>PMC11429838</a> DOI: <a href='https://dx.doi.org/10.3390/biom14091192' target='_blank'>10.3390/biom14091192</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3390/biom14091192','39334958', 'cartilage degeneration')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(3);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(3);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(3);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(3);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3390/biom14091192' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3676);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/30/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv3" value="10.3390/biom14091192" /> <div style="display: none" id="articleAbstract3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Cartilage, a critical tissue for joint function, often degenerates due to osteoarthritis (OA), rheumatoid arthritis (RA), and trauma. Recent research underscores necroptosis, a regulated form of necrosis, as a key player in cartilage degradation. Unlike apoptosis, necroptosis triggers robust inflammatory responses, exacerbating tissue damage. Key mediators such as receptor-interacting serine/threonine-protein kinase-1 (RIPK1), receptor-interacting serine/threonine-protein kinase-3(RIPK3), and mixed lineage kinase domain-like (MLKL) are pivotal in this process. Studies reveal necroptosis contributes significantly to OA and RA pathophysiology, where elevated RIPK3 and associated proteins drive cartilage degradation. Targeting necroptotic pathways shows promise; inhibitors like Necrostatin-1 (Nec-1), GSK'872, and Necrosulfonamide (NSA) reduce necroptotic cell death, offering potential therapeutic avenues. Additionally, autophagy's role in mitigating necroptosis-induced damage highlights the need for comprehensive strategies addressing multiple pathways. Despite these insights, further research is essential to fully understand necroptosis' mechanisms and develop effective treatments. This review synthesizes current knowledge on necroptosis in cartilage degeneration, aiming to inform novel therapeutic approaches for OA, RA, and trauma. </div> <a href="javascript:ShowArticleAbstract(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22OA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">OA</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RA</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cartilage+degeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cartilage degeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22necroptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">necroptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22trauma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">trauma</a></li></ul> <a href="javascript:ShowArticleKeywords(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Necroptosis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Necroptosis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoarthritis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoarthritis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoarthritis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoarthritis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoarthritis%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoarthritis/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cartilage%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cartilage/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cartilage%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cartilage/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor-Interacting+Protein+Serine-Threonine+Kinases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor-Interacting Protein Serine-Threonine Kinases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Rheumatoid%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Rheumatoid/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Rheumatoid%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Rheumatoid/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Rheumatoid%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Rheumatoid/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+Kinases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein Kinases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Imidazoles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Imidazoles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Indoles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Indoles</a></li></ul> <a href="javascript:ShowArticleMeSH(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Basic+Research+Laboratory+Program+of+NRF+(National+Research+Foundation+of+Korea)+of+the+Republic+of+Korea%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NRF-2022R1A4A1028747 Basic Research Laboratory Program of NRF (National Research Foundation of Korea) of the Republic of Korea</a></li></ul> <a href="javascript:ShowArticleGrant(3);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow4"> <td style="min-width: 40px; text-align: center;"> 4 </td> <td> <div id="citation4" class="article-citation"> <b>Lai A</b>, Tamea C, Shou J, Okafor A, Sparks J, Dodd R, Lambert N, Woods C, Schulte O, Kovar S, Barrett T. Retrospective Evaluation of Cryopreserved Human Umbilical Cord Tissue Allografts in the Supplementation of Cartilage Defects Associated with Hip Osteoarthritis. <em class='incite-journal-name' onclick='ShowInCiteJournal(13429);'>J Clin Med</em> 2024;<b>13</b>:4040. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39064079' target='_blank'>39064079</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11277460' target='_blank'>PMC11277460</a> DOI: <a href='https://dx.doi.org/10.3390/jcm13144040' target='_blank'>10.3390/jcm13144040</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3390/jcm13144040','39064079', 'cartilage degeneration')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(4);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(4);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3390/jcm13144040' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(13429);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 06/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/28/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv4" value="10.3390/jcm13144040" /> <div style="display: none" id="articleAbstract4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Background: Osteoarthritis is a chronic disorder that affects the synovial joints by the progressive loss of articular cartilage. In the hip, the largest weight-bearing joint, the deterioration of articular cartilage and acetabular labrum can cause pain, diminishing the quality of life for patients. This study presents changes in reported pain scales from patients who received Wharton's jelly applications to cartilage deterioration in the hip from the observational retrospective repository at Regenative Labs. Methods: Sixty-nine patients were selected based on inclusion criteria with patient-reported pain scales, including the Numeric Pain Rating Scale and the Western Ontario and McMaster University Osteoarthritis Index, collected at the initial application, 30, and 90-day follow-up visits. Thirteen patients received a second allograft application and had additional follow-up visits at 120 and 180 days. Results: Five of the six scales used showed a statistically significant improvement in average scores across the cohort. The greatest improvements were observed in the NPRS with a 31.36% improvement after 90 days and a 44.64% improvement for patients with two applications after 180 days. The minimal clinically important difference (MCID) was also calculated to determine the perceived value of care for each patient with 44.9% of patients exceeding the MCID and 78.3% reporting at least one level of improvement. Conclusions: The positive outcomes for the patients in this cohort suggest WJ to be a promising alternative care option for patients with structural tissue degeneration in the hip refractory to the current standard of care. </div> <a href="javascript:ShowArticleAbstract(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Wharton%e2%80%99s+jelly%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Wharton’s jelly</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cartilage+degeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cartilage degeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22hip+osteoarthritis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">hip osteoarthritis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22umbilical+cord+tissue+allografts%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">umbilical cord tissue allografts</a></li></ul> <a href="javascript:ShowArticleKeywords(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(4);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow5"> <td style="min-width: 40px; text-align: center;"> 5 </td> <td> <div id="citation5" class="article-citation"> <b>Tsushima T</b>, Sasaki E, Sakamoto Y, Kimura Y, Tsuda E, Ishibashi Y. Joint line convergence angle is the most associated alignment factor with the severity of medial knee osteoarthritis. <em class='incite-journal-name' onclick='ShowInCiteJournal(166871);'>J Exp Orthop</em> 2024;<b>11</b>:e70007. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39176253' target='_blank'>39176253</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11339597' target='_blank'>PMC11339597</a> DOI: <a href='https://dx.doi.org/10.1002/jeo2.70007' target='_blank'>10.1002/jeo2.70007</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/jeo2.70007','39176253', 'cartilage degeneration')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(5);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(5);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1002/jeo2.70007' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.1002/jeo2.70007');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(166871);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/jexo/default2.aspx' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 06/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/24/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv5" value="10.1002/jeo2.70007" /> <div style="display: none" id="articleAbstract5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">Purpose</div><div class="abstract-content">The purpose of this study was to evaluate the relationship between the joint line convergence angle (JLCA) and the severity of medial knee osteoarthritis (OA). We hypothesise that JLCA is the most associated factor with the severity of medial knee OA. </div><div class="abstract-label">Methods</div><div class="abstract-content">This retrospective study included a total of 202 knees that underwent either high tibial osteotomy or medial meniscus repair/partial resection. Kellgren-Lawrence grade and hip-knee-ankle angle (HKAA), mechanical lateral distal femoral angle (mLDFA), medial proximal tibial angle (MPTA) and JLCA were assessed from preoperative radiographs. Medial meniscus extrusion (MME) was measured using preoperative magnetic resonance imaging. The International Cartilage Research Society (ICRS) grade on the medial femoral condyle and medial tibial plateau were also assessed. The relationships between JLCA and Kellgren-Lawrence grades and MME and ICRS grades were analysed using Spearman's correlation test and regression analysis. </div><div class="abstract-label">Results</div><div class="abstract-content">The JLCA was correlated with the Kellgren-Lawrence grade (R = 0.765, p < 0.001), MME (R = 0.638, p < 0.001), ICRS grade on the MFC (R = 0.586, p < 0.001) and the MTP (R = 0.586, p < 0.001). Regression analysis showed that age (p = 0.002) and JLCA (p < 0.001) were associated with Kellgren-Lawrence grade. Furthermore, JLCA was related to ICRS grade on the MFC (p < 0.001) and MTP (p < 0.001). </div><div class="abstract-label">Conclusion</div><div class="abstract-content">The JLCA, reflecting radiological severity, meniscus status, and cartilage lesion, was the most associated alignment parameter in the severity of medial knee OA. The JLCA may be beneficial for quantitative assessment of medial knee OA. </div><div class="abstract-label">Level of Evidence</div><div class="abstract-content">Level III, retrospective cohort study. </div> <a href="javascript:ShowArticleAbstract(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kellgren%e2%80%93Lawrence+grade%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kellgren–Lawrence grade</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cartilage+degeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cartilage degeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22joint+line+convergence+angle%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">joint line convergence angle</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22medial+knee+osteoarthritis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">medial knee osteoarthritis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22medial+meniscus+extrusion%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">medial meniscus extrusion</a></li></ul> <a href="javascript:ShowArticleKeywords(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(5);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow6"> <td style="min-width: 40px; text-align: center;"> 6 </td> <td> <div id="citation6" class="article-citation"> <b>Wu X</b>, Sun AR, Crawford R, Xiao Y, Wang Y, Prasadam I, Mao X. Inhibition of Leukotriene A<sub>4</sub> Hydrolase Suppressed Cartilage Degradation and Synovial Inflammation in a Mouse Model of Experimental Osteoarthritis. <em class='incite-journal-name' onclick='ShowInCiteJournal(4658);'>Cartilage</em> 2024;<b>15</b>:184-194. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37086004' target='_blank'>37086004</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11368897' target='_blank'>PMC11368897</a> DOI: <a href='https://dx.doi.org/10.1177/19476035231169940' target='_blank'>10.1177/19476035231169940</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1177/19476035231169940','37086004', 'cartilage degeneration')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(6);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(6);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(6);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(6);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1177/19476035231169940' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4658);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://mc.manuscriptcentral.com/cart' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 12/18/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 03/24/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 03/29/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 04/23/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv6" value="10.1177/19476035231169940" /> <div style="display: none" id="articleAbstract6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">OBJECTIVE</div><div class="abstract-content">Chronic inflammation plays an important role in the osteoarthritis (OA) pathology but how this influence OA disease progression is unclear. Leukotriene B4 (LTB4) is a potent proinflammatory lipid mediator generated from arachidonic acid through the sequential activities of 5-lipoxygenase, 5-lipoxygenase-activating protein, Leukotriene A4 hydrolase (LTA4H) and its downstream product LTB4. The aim of this study is to investigate the involvement and the potential therapeutic target of the LTB4 pathway in OA disease progression. </div><div class="abstract-label">DESIGN</div><div class="abstract-content">Both clinical human cartilage samples (n = 7) and mice experimental OA models (n = 6) were used. The levels of LTA4H and leukotriene B4 receptor 1 were first examined using immunostaining in human OA/non-OA cartilage and mice experimental OA models. We also determined whether the LTA4H pathway was associated with cartilage degeneration and synovitis inflammation in OA mice models and human articular chondrocytes. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">We found that both LTA4H and LTB4 receptor (BLT1) were highly expressed in human and mice OA cartilage. Inhibition of LTA4H suppressed cartilage degeneration and synovitis in OA mice model. Furthermore, inhibition of LTA4H promoted cartilage regeneration by upregulating chondrogenic genes expression such as aggrecan (ACAN), collagen 2A1 (COL2A1), and SRY-Box transcription factor 9 (SOX9). </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">Our results indicate that the LTA4H pathway is a crucial regulator of OA pathogenesis and suggest that LTA4H could be a therapeutic target in combat OA. </div> <a href="javascript:ShowArticleAbstract(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cartilage+degeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cartilage degeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22leukotriene+A4+hydrolase%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">leukotriene A4 hydrolase</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22osteoarthritis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">osteoarthritis</a></li></ul> <a href="javascript:ShowArticleKeywords(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Experimental%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Experimental/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cartilage%2c+Articular%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cartilage, Articular/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cartilage%2c+Articular%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cartilage, Articular/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chondrocytes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chondrocytes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chondrocytes%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chondrocytes/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epoxide+Hydrolases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epoxide Hydrolases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Leukotriene+B4%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Leukotriene B4/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoarthritis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoarthritis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Leukotriene+B4%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Leukotriene B4/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Synovitis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Synovitis</a></li></ul> <a href="javascript:ShowArticleMeSH(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Natural+Science+Foundation+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">National Natural Science Foundation of China</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prince+Charles+Hospital+Foundation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prince Charles Hospital Foundation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Health+and+Medical+Research+Council%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">National Health and Medical Research Council</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hunan+Provincial+Science+and+Technology+Department%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hunan Provincial Science and Technology Department</a></li></ul> <a href="javascript:ShowArticleGrant(6);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow7"> <td style="min-width: 40px; text-align: center;"> 7 </td> <td> <div id="citation7" class="article-citation"> <b>Chen J</b>, Zeng Q, Wang X, Xu R, Wang W, Huang Y, Sun Q, Yuan W, Wang P, Chen D, Tong P, Jin H. Aberrant methylation and expression of TNXB promote chondrocyte apoptosis and extracullar matrix degradation in hemophilic arthropathy via AKT signaling. <em class='incite-journal-name' onclick='ShowInCiteJournal(8168);'>eLife</em> 2024;<b>13</b>:RP93087. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38819423' target='_blank'>38819423</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11142640' target='_blank'>PMC11142640</a> DOI: <a href='https://dx.doi.org/10.7554/elife.93087' target='_blank'>10.7554/elife.93087</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.7554/elife.93087','38819423', 'cartilage degeneration')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(7);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(7);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(7);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(7);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.7554/elife.93087' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(8168);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/01/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv7" value="10.7554/elife.93087" /> <div style="display: none" id="articleAbstract7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Recurrent joint bleeding in hemophilia patients frequently causes hemophilic arthropathy (HA). Drastic degradation of cartilage is a major characteristic of HA, but its pathological mechanisms has not yet been clarified. In HA cartilages, we found server matrix degradation and increased expression of DNA methyltransferase proteins. We thus performed genome-wide DNA methylation analysis on human HA (N=5) and osteoarthritis (OA) (N=5) articular cartilages, and identified 1228 differentially methylated regions (DMRs) associated with HA. Functional enrichment analyses revealed the association between DMR genes (DMGs) and extracellular matrix (ECM) organization. Among these DMGs, Tenascin XB (TNXB) expression was down-regulated in human and mouse HA cartilages. The loss of Tnxb in F8-/- mouse cartilage provided a disease-promoting role in HA by augmenting cartilage degeneration and subchondral bone loss. Tnxb knockdown also promoted chondrocyte apoptosis and inhibited phosphorylation of AKT. Importantly, AKT agonist showed chondroprotective effects following Tnxb knockdown. Together, our findings indicate that exposure of cartilage to blood leads to alterations in DNA methylation, which is functionally related to ECM homeostasis, and further demonstrate a critical role of TNXB in HA cartilage degeneration by activating AKT signaling. These mechanistic insights allow development of potentially new strategies for HA cartilage protection. </div> <a href="javascript:ShowArticleAbstract(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22DNA+methylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DNA methylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cartilage+degeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cartilage degeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cell+biology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cell biology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22chondrocyte+apoptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">chondrocyte apoptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22genetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22genomics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">genomics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22hemophilic+arthropathy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">hemophilic arthropathy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22human%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">human</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mouse%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mouse</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22tenascin+XB%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">tenascin XB</a></li></ul> <a href="javascript:ShowArticleKeywords(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hemophilia+A%2fcomplications%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hemophilia A/complications</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoarthritis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoarthritis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoarthritis%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoarthritis/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoarthritis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoarthritis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Proto-Oncogene+Proteins+c-akt%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Proto-Oncogene Proteins c-akt/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Proto-Oncogene+Proteins+c-akt%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Proto-Oncogene Proteins c-akt/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tenascin%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tenascin/metabolism</a></li><li><a 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National Natural Science Foundation of China</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Natural+Science+Foundation+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">82104891 National Natural Science Foundation of China</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Natural+Science+Foundation+of+Zhejiang+Province%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">LQ22H270006 Natural Science Foundation of Zhejiang Province</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Natural+Science+Foundation+of+Zhejiang+Province%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">LR23H270001 Natural Science Foundation of Zhejiang Province</a></li></ul> <a href="javascript:ShowArticleGrant(7);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow8"> <td style="min-width: 40px; text-align: center;"> 8 </td> <td> <div id="citation8" class="article-citation"> <b>Liu L</b>, Zhang B, Zhou Z, Yang J, Li A, Wu Y, Peng Z, Li X, Liu Z, Leng X, Zhao C, Dong H, Zhao W. Integrated Network Pharmacology and Experimental Validation Approach to Investigate the Mechanisms of Radix Rehmanniae Praeparata - Angelica Sinensis - Radix Achyranthis Bidentatae in Treating Knee Osteoarthritis. <em class='incite-journal-name' onclick='ShowInCiteJournal(7933);'>Drug Des Devel Ther</em> 2024;<b>18</b>:1583-1602. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38765877' target='_blank'>38765877</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11102756' target='_blank'>PMC11102756</a> DOI: <a href='https://dx.doi.org/10.2147/dddt.s455006' target='_blank'>10.2147/dddt.s455006</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.2147/dddt.s455006','38765877', 'cartilage degeneration')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(8);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(8);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(8);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(8);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.2147/dddt.s455006' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/311d5af04190bbc96de63947468db84b/dddt-18-1583.PMC11102756.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.2147/dddt.s455006');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(7933);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 12/14/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 05/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 05/22/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv8" value="10.2147/dddt.s455006" /> <div style="display: none" id="articleAbstract8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">Background</div><div class="abstract-content">Knee osteoarthritis (KOA) is a persistent degenerative condition characterized by the deterioration of cartilage. The Chinese herbal formula Radix Rehmanniae Praeparata- Angelica Sinensis-Radix Achyranthis Bidentatae (RAR) has often been used in effective prescriptions for KOA as the main functional drug, but its underlying mechanism remains unclear. Therefore, network pharmacology and verification experiments were employed to investigate the impact and mode of action of RAR in the treatment of KOA. </div><div class="abstract-label">Methods</div><div class="abstract-content">The destabilization of the medial meniscus model (DMM) was utilized to assess the anti-KOA effect of RAR by using gait analysis, micro-computed tomography (Micro-CT), and histology. Primary chondrocytes were extracted from the rib cartilage of a newborn mouse. The protective effects of RAR on OA cells were evaluated using a CCK-8 assay. The antioxidative effect of RAR was determined by measuring reactive oxygen species (ROS), superoxide dismutase (SOD), and glutathione (GSH) production. Furthermore, network pharmacology and molecular docking were utilized to propose possible RAR targets for KOA, which were further verified through experiments. </div><div class="abstract-label">Results</div><div class="abstract-content">In vivo, RAR significantly ameliorated DMM-induced KOA characteristics, such as subchondral bone sclerosis, cartilage deterioration, gait abnormalities, and the degree of knee swelling. In vitro, RAR stimulated chondrocyte proliferation and the expression of Col2a1, Comp, and Acan. Moreover, RAR treatment significantly reduced ROS accumulation in an OA cell model induced by IL-1β and increased the activity of antioxidant enzymes (SOD and GSH). Network pharmacology analysis combined with molecular docking showed that Mapk1 might be a key therapeutic target. Subsequent research showed that RAR could downregulate Mapk1 mRNA levels in IL-1β-induced chondrocytes and DMM-induced rats. </div><div class="abstract-label">Conclusion</div><div class="abstract-content">RAR inhibited extracellular matrix (ECM) degradation and oxidative stress response via the MAPK signaling pathway in KOA, and Mapk1 may be a core target. </div> <a href="javascript:ShowArticleAbstract(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mapk1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mapk1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RAR%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RAR</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cartilage+degeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cartilage degeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22knee+osteoarthritis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">knee osteoarthritis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22network+pharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">network pharmacology</a></li></ul> <a href="javascript:ShowArticleKeywords(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Angelica+sinensis%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Angelica sinensis/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoarthritis%2c+Knee%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoarthritis, Knee/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoarthritis%2c+Knee%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoarthritis, Knee/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoarthritis%2c+Knee%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoarthritis, Knee/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drugs%2c+Chinese+Herbal%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drugs, Chinese Herbal/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drugs%2c+Chinese+Herbal%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drugs, Chinese Herbal/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drugs%2c+Chinese+Herbal%2fisolation+%26amp%3b+purification%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drugs, Chinese Herbal/isolation & purification</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Achyranthes%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Achyranthes/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Network+Pharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Network Pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rehmannia%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rehmannia/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Molecular+Docking+Simulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Molecular Docking Simulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cells%2c+Cultured%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cells, Cultured</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chondrocytes%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chondrocytes/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chondrocytes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chondrocytes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chondrocytes%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chondrocytes/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li></ul> <a href="javascript:ShowArticleMeSH(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant8" class="article-abstract"> <b style="display: block; 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text-align: center;"> 9 </td> <td> <div id="citation9" class="article-citation"> <b>Fu CL</b>, Lin YM, Tu HS, Ye JX, Huang YF, Ma DZ, Zheng CS. [Mechanism of Tougu Xiaotong Capsules in delaying degeneration of osteoarthritis by regulating cholesterol metabolism in chondrocytes through lncRNA MALAT1]. <em>ZHONGGUO ZHONG YAO ZA ZHI = ZHONGGUO ZHONGYAO ZAZHI = CHINA JOURNAL OF CHINESE MATERIA MEDICA</em> 2024;<b>49</b>:1785-1792. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38812190' target='_blank'>38812190</a> DOI: <a href='https://dx.doi.org/10.19540/j.cnki.cjcmm.20231212.706' target='_blank'>10.19540/j.cnki.cjcmm.20231212.706</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.19540/j.cnki.cjcmm.20231212.706','38812190', 'cartilage degeneration')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(9);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(9);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(9);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 05/31/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv9" value="10.19540/j.cnki.cjcmm.20231212.706" /> <div style="display: none" id="articleAbstract9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">From the perspective of lncRNA MALAT1 regulating cholesterol metabolism in chondrocytes, this paper explores the effect and mechanism of Tougu Xiaotong Capsules(TGXTC) in delaying the degeneration of osteoarthritis. After one week of adaptive feeding, 48(8-week-old) C57BL/6 mice were randomly divided into a blank group(12 mice) and a model group(36 mice) by random number table method. The mice in the model group were anesthetized by inhalation of 5% isoflurane, and the OA model was induced by Hulth method. The experiment randomly divided the mice into a model group(12 mice), a drug-positive group(taururso-deoxycholic acid)(12 mice), and a TGXTC group(12 mice). The drug-positive group was given 500 mg·kg~(-1) taurodeoxycholic acid by intragastric administration. TGXTC group was given TGXTC 368 mg·kg~(-1) by gavage. The blank group and model group were given the same amount of normal saline for four weeks. After the intervention, the mice in each group were killed under anesthesia, and the knee cartilage tissue was separated and collected. The morphologic changes of knee cartilage were observed. The level of lncRNA MALAT1 in the cartilage tissue was detected by real-time PCR. The protein expressions of ABCA1, ApoA1, LXRβ, CHOP, and caspase-3 in mouse articular cartilage were detected by Western blot. Lentivirus-coated plasmid was used to transfect mouse chondrocytes with sh-MALAT1. The gene levels of lncRNA MALAT1 in mouse chondrocytes transfected with sh-MALAT1 were detected by real-time PCR. Western blot was used to detect the effect of TGXTC on the protein content of ABCA1, ApoA1, LXRβ, CHOP, and caspase-3 in thapsigargin(TG)-induced mouse chondrocytes after lncRNA MALAT1 knockdown. Flow cytometry was used to detect the effect of TGXTC on apoptosis of TG-induced mouse chondrocytes after lncRNA MALAT1 knockdown. The results of HE and saffranine O staining showed that compared with the model group, the structure of the cartilage layer was basically intact; the damage degree of joint structure was significantly improved, and the cartilage matrix was significantly enhanced by saffranine O staining in the TGXTC group and drug-positive group. Compared with the model group, the lncRNA MALAT1 level was significantly decreased in the TGXTC group and drug-positive group. Compared with the model group, the protein content of ABCA1, ApoA1, and LXRβ was significantly increased, while that of CHOP and caspase-3 in the TGXTC group and drug-positive group significantly decreased. Compared with the TG group, the lncRNA MALAT1 level in the TG+sh-MALAT1 group was decreased. The lncRNA MALAT1 level in the TG+sh-MA-LAT1+TGXTC group was increased compared with the TG+TGXTC group. Western blot results showed that compared with the model group, protein expressions of ABCA1, ApoA1, LXRβ, CHOP, and caspase-3 in the TGXTC group were significantly decreased, after lncRNA MALAT1 knockdown, the regulation and apoptosis of ABCA1, ApoA1, LXRβ, CHOP, and caspase-3 in TG-induced mouse chondrocytes were weakened by TGXTC. TGXTC can improve the disorder of cholesterol metabolism in OA chondrocytes and delay OA degeneration, which is closely related to the regulation of lncRNA MALAT1. </div> <a href="javascript:ShowArticleAbstract(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tougu+Xiaotong+Capsules%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tougu Xiaotong Capsules</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cartilage+degeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cartilage degeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cholesterol+metabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cholesterol metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22osteoarthritis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">osteoarthritis</a></li></ul> <a href="javascript:ShowArticleKeywords(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Long+Noncoding%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Long Noncoding/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Long+Noncoding%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Long Noncoding/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chondrocytes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chondrocytes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chondrocytes%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chondrocytes/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoarthritis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoarthritis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoarthritis%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoarthritis/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoarthritis%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoarthritis/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cholesterol%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cholesterol/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drugs%2c+Chinese+Herbal%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drugs, Chinese Herbal/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drugs%2c+Chinese+Herbal%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drugs, Chinese Herbal/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Capsules%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Capsules</a></li></ul> <a href="javascript:ShowArticleMeSH(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(9);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow10"> <td style="min-width: 40px; text-align: center;"> 10 </td> <td> <div id="citation10" class="article-citation"> <b>Ripmeester EG</b>, Steijns JS, Wijnands KA, Stassen RH, Pitelka V, Peeters LC, Cremers A, Astryde NMSA, Chabronova A, Surtel DA, Emans PJ, van den Akker GG, van Rietbergen B, van Rhijn LW, Caron MM, Welting TJ. The BMP7-Derived Peptide p[63-82] Reduces <span class="highlight-field">Cartilage Degeneration</span> in the Rat ACLT-pMMx Model for Posttraumatic Osteoarthritis. <em class='incite-journal-name' onclick='ShowInCiteJournal(4658);'>Cartilage</em> 2024:19476035241233659. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38501739' target='_blank'>38501739</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569685' target='_blank'>PMC11569685</a> DOI: <a href='https://dx.doi.org/10.1177/19476035241233659' target='_blank'>10.1177/19476035241233659</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1177/19476035241233659','38501739', 'cartilage degeneration')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(10);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(10);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(10);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1177/19476035241233659' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4658);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://mc.manuscriptcentral.com/cart' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/21/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 01/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 02/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 03/20/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv10" value="10.1177/19476035241233659" /> <div style="display: none" id="articleAbstract10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">OBJECTIVE</div><div class="abstract-content">Osteoarthritis (OA) is characterized by articular cartilage erosion, pathological subchondral bone changes, and signs of synovial inflammation and pain. We previously identified p[63-82], a bone morphogenetic protein 7 (BMP7)-derived bioactive peptide that attenuates structural cartilage degeneration in the rat medial meniscal tear-model for posttraumatic OA. This study aimed to evaluate the cartilage erosion-attenuating activity of p[63-82] in a different preclinical model for OA (anterior cruciate ligament transection-partial medial meniscectomy [anterior cruciate ligament transection (ACLT)-pMMx]). The disease-modifying action of the p[63-82] was followed-up in this model for 5 and 10 weeks. </div><div class="abstract-label">DESIGN</div><div class="abstract-content">Skeletally mature male Lewis rats underwent ACLT-pMMx surgery. Rats received weekly intra-articular injections with either saline or 500 ng p[63-82]. Five and 10 weeks postsurgery, rats were sacrificed, and subchondral bone characteristics were determined using microcomputed tomography (µCT). Histopathological evaluation of cartilage degradation and Osteoarthritis Research Society International (OARSI)-scoring was performed following Safranin-O/Fast Green staining. Pain-related behavior was measured by incapacitance testing and footprint analysis. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Histopathological evaluation at 5 and 10 weeks postsurgery showed reduced cartilage degeneration and a significantly reduced OARSI score, whereas no significant changes in subchondral bone characteristics were found in the p[63-82]-treated rats compared to the saline-treated rats. ACLT-pMMx-induced imbalance of static weightbearing capacity in the p[63-82] group was significantly improved compared to the saline-treated rats at weeks 5 postsurgery. Footprint analysis scores in the p[63-82]-treated rats demonstrated improvement at week 10 postsurgery. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">Weekly intra-articular injections of p[63-82] in the rat ACLT-pMMx posttraumatic OA model resulted in reduced degenerative cartilage changes and induced functional improvement in static weightbearing capacity during follow-up. </div> <a href="javascript:ShowArticleAbstract(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22anterior+cruciate+ligament+tear%e2%80%94partial+meniscectomy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">anterior cruciate ligament tear—partial meniscectomy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22articular+cartilage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">articular cartilage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cartilage+degeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cartilage degeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22osteoarthritis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">osteoarthritis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22pain%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">pain</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22peptides%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">peptides</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22subchondral+bone%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">subchondral bone</a></li></ul> <a href="javascript:ShowArticleKeywords(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dutch+Arthritis+Association%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dutch Arthritis Association</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stichting+De+Weijerhorst%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stichting De Weijerhorst</a></li></ul> <a href="javascript:ShowArticleGrant(10);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow11"> <td style="min-width: 40px; text-align: center;"> 11 </td> <td> <div id="citation11" class="article-citation"> <b>Jasiński T</b>, Turek B, Kaczorowski M, Brehm W, Skierbiszewska K, Bonecka J, Domino M. Equine Models of Temporomandibular Joint Osteoarthritis: A Review of Feasibility, Biomarkers, and Molecular Signaling. <em class='incite-journal-name' onclick='ShowInCiteJournal(3840);'>Biomedicines</em> 2024;<b>12</b>:542. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38540155' target='_blank'>38540155</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10968442' target='_blank'>PMC10968442</a> DOI: <a href='https://dx.doi.org/10.3390/biomedicines12030542' target='_blank'>10.3390/biomedicines12030542</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.3390%2fbiomedicines12030542%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 2</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.3390%2fbiomedicines12030542')">Impact Index Per Article: 2.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3390/biomedicines12030542','38540155', 'cartilage degeneration')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(11);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(11);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3390/biomedicines12030542' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.3390/biomedicines12030542');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3840);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 02/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 02/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/11/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv11" value="10.3390/biomedicines12030542" /> <div style="display: none" id="articleAbstract11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Osteoarthritis (OA) of the temporomandibular joint (TMJ) occurs spontaneously in humans and various animal species, including horses. In humans, obtaining tissue samples is challenging and clinical symptoms appear late in the disease progression. Therefore, genetically modified, induced, and naturally occurring animal models play a crucial role in understanding the pathogenesis and evaluating potential therapeutic interventions for TMJ OA. Among the naturally occurring models, the equine TMJ OA model is characterized by slow, age-related progression, a wide range of clinical examinations, and imaging modalities that can be performed on horses, as well as easy tissue and synovial fluid collection. The morphological and functional similarities of TMJ structures in both species make the equine model of TMJ OA an excellent opportunity to track disease progression and response to treatment. However, much work remains to be carried out to determine the utility of human TMJ OA biomarkers in horses. Among the main TMJ OA biomarkers, IL-1, IL-6, TGF-β, TNF-α, and PGE2 have been recently investigated in the equine model. However, the majority of biomarkers for cartilage degradation, chondrocyte hypertrophy, angiogenesis, and TMJ overload-as well as any of the main signaling pathways-have not been studied so far. Therefore, it would be advisable to focus further research on equine specimens, considering both mediators and signaling. </div> <a href="javascript:ShowArticleAbstract(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cartilage+degeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cartilage degeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22horse%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">horse</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22human%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">human</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mechanical+loading%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mechanical loading</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22osteoarthritis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">osteoarthritis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22regulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">regulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22remodeling%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">remodeling</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22targeted+treatment%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">targeted treatment</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22temporomandibular+joint%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">temporomandibular joint</a></li></ul> <a href="javascript:ShowArticleKeywords(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(11);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow12"> <td style="min-width: 40px; text-align: center;"> 12 </td> <td> <div id="citation12" class="article-citation"> <b>Takada S</b>, Nodera R, Yoshioka K. Effects of Diclofenac Etalhyaluronate (SI-613/ONO-5704) on <span class="highlight-field">Cartilage Degeneration</span> in Arthritic Rats and Inflammatory Cytokine-Stimulated Human Chondrocytes. <em class='incite-journal-name' onclick='ShowInCiteJournal(4658);'>Cartilage</em> 2024:19476035231224050. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38317317' target='_blank'>38317317</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569655' target='_blank'>PMC11569655</a> DOI: <a href='https://dx.doi.org/10.1177/19476035231224050' target='_blank'>10.1177/19476035231224050</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1177/19476035231224050','38317317', 'cartilage degeneration')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(12);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(12);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1177/19476035231224050' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4658);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://mc.manuscriptcentral.com/cart' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/10/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 12/08/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/15/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 02/07/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv12" value="10.1177/19476035231224050" /> <div style="display: none" id="articleAbstract12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">OBJECTIVE</div><div class="abstract-content">Cartilage degeneration is a key feature of osteoarthritis (OA) and rheumatoid arthritis and is thought to negatively impact patients' quality of life. Diclofenac etalhyaluronate (DEH, SI-613/ONO-5704) is a hyaluronic acid (HA) derivative chemically bound to diclofenac (DF) that has been reported to improve OA symptoms; however, its effect on cartilage degeneration remains unknown. In the present study, we investigated the chondroprotective effect of DEH in rats with collagen-induced arthritis and interleukin-1β-stimulated human chondrocytes. </div><div class="abstract-label">DESIGN</div><div class="abstract-content">Rats with collagen-induced arthritis were administered DEH and HA intra-articularly, and DF orally. Knee joint swelling, histological scores of articular cartilage, and inflammatory (Il1b) and catabolic (Mmp3 and Mmp13) gene expression in the synovial tissue and cartilage were evaluated. In vitro direct effects of DEH on matrix metalloproteinase (MMP)-3 and MMP-13 expression were examined in interleukin-1β-stimulated human chondrocytes. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">In a rat model of collagen-induced arthritis, a single intra-articular dose of DEH inhibited knee joint inflammation and cartilage degeneration. Daily oral administration of DF had similar effects. Conversely, HA administered as a single intra-articular dose had no effect. Only DEH inhibited Mmp3 gene expression in the cartilage, whereas DEH and DF inhibited Mmp3 and Mmp13 mRNA expression in the synovial tissue. In interleukin-1β-stimulated human chondrocytes, DEH and HA inhibited MMP-3 and MMP-13 production, whereas DF had no effect. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">In this study, we demonstrated the chondroprotective effect of DEH in rats with collagen-induced arthritis and in interleukin-1β-stimulated human chondrocytes. Thus, DEH may suppress cartilage degeneration in patients with musculoskeletal diseases, such as OA. </div> <a href="javascript:ShowArticleAbstract(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cartilage+degeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cartilage degeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22diagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22diclofenac+etalhyaluronate%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">diclofenac etalhyaluronate</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22intra-articular+injection%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">intra-articular injection</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22matrix+metalloproteinase%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">matrix metalloproteinase</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22osteoarthritis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">osteoarthritis</a></li></ul> <a href="javascript:ShowArticleKeywords(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(12);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow13"> <td style="min-width: 40px; text-align: center;"> 13 </td> <td> <div id="citation13" class="article-citation"> <b>Fang L</b>, Wang Z, Liu J, Lin Y, Hao W. General Control Non-derepressible 2 Alleviates <span class="highlight-field">Cartilage Degeneration</span> and Inhibits NLRP3 Inflammasome Activation in Osteoarthritis. <em class='incite-journal-name' onclick='ShowInCiteJournal(14117);'>J Histochem Cytochem</em> 2024;<b>72</b>:95-108. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38213081' target='_blank'>38213081</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10851878' target='_blank'>PMC10851878</a> DOI: <a href='https://dx.doi.org/10.1369/00221554231225514' target='_blank'>10.1369/00221554231225514</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1369/00221554231225514','38213081', 'cartilage degeneration')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(13);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(13);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(13);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1369/00221554231225514' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(14117);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/11/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/15/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/13/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv13" value="10.1369/00221554231225514" /> <div style="display: none" id="articleAbstract13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">This study aimed to evaluate the effects of general control non-derepressible 2 (GCN2) on osteoarthritis (OA) in vivo and in vitro. First, anterior cruciate ligament transection (ACLT)-induced rat model and interleukin (IL)-1β-induced ATDC5 chondrocyte were established. Hematoxylin and eosin staining and safranin O/fast green staining were employed for analyzing the histological changes in the rat cartilage. In addition, immunohistochemistry, quantitative real-time polymerase chain reaction, enzyme-linked immunosorbent assay, western blot, and immunofluorescence staining were employed for examining cartilage degeneration-, inflammation-, autophagy-, and NLR family pyrin domain containing 3 (NLRP3) inflammasome-associated genes expression. Moreover, 2,7-dichlorodihydrofluorescein acetoacetic acid probe was utilized for examining the intracellular reactive oxygen species. In addition, 5-ethynyl-2'-deoxyuridine assay and flow cytometry were applied for detecting chondrocyte proliferation and apoptosis IL-1β-treated ATDC5 chondrocytes. GCN2 overexpression ameliorated articular cartilage degeneration and inflammation but promoted chondrocyte autophagy in ACLT-induced OA rats. Similarly, we demonstrated that the upregulation of GCN2 could promote chondrocyte proliferation, suppress chondrocyte apoptosis, attenuate chondrocyte inflammation and extracellular matrix degradation, and promote chondrocyte autophagy. Moreover, GCN2 overexpression could inhibit the activation of NLRP3 inflammasome in IL-1β-induced ATDC5 chondrocyte. Furthermore, 3-methyladenine neutralized the protective and autophagy-promoting effects of GCN2 overexpression on ATDC5 chondrocytes. GCN2 could attenuate inflammation and cartilage degeneration, promote chondrocyte autophagy, and inhibit NLRP3 inflammasome activation in OA. </div> <a href="javascript:ShowArticleAbstract(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GCN2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GCN2</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NLRP3%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NLRP3</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22autophagy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">autophagy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cartilage+degeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cartilage degeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22osteoarthritis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">osteoarthritis</a></li></ul> <a href="javascript:ShowArticleKeywords(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammasomes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammasomes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NLR+Family%2c+Pyrin+Domain-Containing+3+Protein%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NLR Family, Pyrin Domain-Containing 3 Protein/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoarthritis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoarthritis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoarthritis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoarthritis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cartilage%2c+Articular%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cartilage, Articular</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apoptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apoptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chondrocytes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chondrocytes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Interleukin-1beta%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Interleukin-1beta/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Interleukin-1beta%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Interleukin-1beta/pharmacology</a></li></ul> <a href="javascript:ShowArticleMeSH(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(13);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow14"> <td style="min-width: 40px; text-align: center;"> 14 </td> <td> <div id="citation14" class="article-citation"> <b>Arora D</b>, Taneja Y, Sharma A, Dhingra A, Guarve K. Role of Apoptosis in the Pathogenesis of Osteoarthritis: An Explicative Review. <em class='incite-journal-name' onclick='ShowInCiteJournal(164341);'>Curr Rheumatol Rev</em> 2024;<b>20</b>:2-13. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37670694' target='_blank'>37670694</a> DOI: <a href='https://dx.doi.org/10.2174/1573397119666230904150741' target='_blank'>10.2174/1573397119666230904150741</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.2174/1573397119666230904150741','37670694', 'cartilage degeneration')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(14);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(14);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(14);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.2174/1573397119666230904150741' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(164341);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/14/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 05/29/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/20/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/07/2023]</span></span> </div> <input type="hidden" name="doiv" id="doiv14" value="10.2174/1573397119666230904150741" /> <div style="display: none" id="articleAbstract14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Apoptosis is a complex regulatory, active cell death process that plays a role in cell development, homeostasis, and ageing. Cancer, developmental defects, and degenerative diseases are all pathogenic disorders caused by apoptosis dysregulation. Osteoarthritis (OA) is by far the most frequently diagnosed joint disease in the aged, and it is characterized by the ongoing breakdown of articular cartilage, which causes severe disability. Multiple variables regulate the anabolic and catabolic pathways of the cartilage matrix, which either directly or indirectly contribute to cartilage degeneration in osteoarthritis. Articular cartilage is a highly specialized tissue made up of an extracellular matrix of cells that are tightly packed together. As a result, chondrocyte survival is crucial for the preservation of an optimal cartilage matrix, and chondrocyte characteristics and survival compromise may result in articular cartilage failure. Inflammatory cytokines can either promote or inhibit apoptosis, the process of programmed cell death. Pro-apoptotic cytokines like TNF-α can induce cell death, while anti-apoptotic cytokines like IL-4 and IL-10 protect against apoptosis. The balance between these cytokines plays a critical role in determining cell fate and has implications for tissue damage and disease progression. Similarly, they contribute to the progression of OA by disrupting the metabolic balance in joint tissues by promoting catabolic and anabolic pathways. Their impact on cell joints, as well as the impacts of cell signalling pathways on cytokines and inflammatory substances, determines their function in osteoarthritis development. Apoptosis is evident in osteoarthritic cartilage; however, determining the relative role of chondrocyte apoptosis in the aetiology of OA is difficult, and the rate of apoptotic chondrocytes in osteoarthritic cartilage is inconsistent. The current study summarises the role of apoptosis in the development of osteoarthritis, the mediators, and signalling pathways that trigger the cascade of events, and the other inflammatory features involved. </div> <a href="javascript:ShowArticleAbstract(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apoptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apoptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22anabolic.%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">anabolic.</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cartilage+degeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cartilage degeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22catabolic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">catabolic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22chondrocytes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">chondrocytes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mediators%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mediators</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22osteoarthritis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">osteoarthritis</a></li></ul> <a href="javascript:ShowArticleKeywords(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apoptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apoptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cartilage%2c+Articular%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cartilage, Articular</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chondrocytes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chondrocytes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chondrocytes%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chondrocytes/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cytokines%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cytokines/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoarthritis%2fetiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoarthritis/etiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoarthritis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoarthritis/pathology</a></li></ul> <a href="javascript:ShowArticleMeSH(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(14);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow15"> <td style="min-width: 40px; text-align: center;"> 15 </td> <td> <div id="citation15" class="article-citation"> <b>Edderkaoui B</b>. Chemokines in Cartilage Regeneration and Degradation: New Insights. <em class='incite-journal-name' onclick='ShowInCiteJournal(11724);'>Int J Mol Sci</em> 2023;<b>25</b>:381. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38203552' target='_blank'>38203552</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10779035' target='_blank'>PMC10779035</a> DOI: <a href='https://dx.doi.org/10.3390/ijms25010381' target='_blank'>10.3390/ijms25010381</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.3390%2fijms25010381%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 3</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.3390%2fijms25010381')">Impact Index Per Article: 3.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3390/ijms25010381','38203552', 'cartilage degeneration')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(15);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(15);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(15);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3390/ijms25010381' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11724);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 12/07/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 12/24/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/25/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/12/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv15" value="10.3390/ijms25010381" /> <div style="display: none" id="articleAbstract15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Cartilage plays a crucial role in the human body by forming long bones during development and growth to bear loads on joints and intervertebral discs. However, the increasing prevalence of cartilage degenerative disorders is a growing public health concern, especially due to the poor innate regenerative capacity of cartilage. Chondrocytes are a source of several inflammatory mediators that play vital roles in the pathogenesis of cartilage disorders. Among these mediators, chemokines have been explored as potential contributors to cartilage degeneration and regeneration. Our review focuses on the progress made during the last ten years in identifying the regulators and roles of chemokines and their receptors in different mechanisms related to chondrocytes and cartilage. Recent findings have demonstrated that chemokines influence cartilage both positively and negatively. Their induction and involvement in either process depends on the local molecular environment and is both site- and time-dependent. One of the challenges in defining the role of chemokines in cartilage pathology or regeneration is the apparent redundancy in the interaction of chemokines with their receptors. Hence, it is crucial to determine, for each situation, whether targeting specific chemokines or their receptors will help in developing effective therapeutic strategies for cartilage repair. </div> <a href="javascript:ShowArticleAbstract(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cartilage+degeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cartilage degeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cartilage+formation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cartilage formation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22chemokine+receptors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">chemokine receptors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22chemokines%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">chemokines</a></li></ul> <a href="javascript:ShowArticleKeywords(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cartilage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cartilage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chondrocytes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chondrocytes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chemokines%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chemokines</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cartilage+Diseases%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cartilage Diseases</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation+Mediators%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation Mediators</a></li></ul> <a href="javascript:ShowArticleMeSH(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(15);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow16"> <td style="min-width: 40px; text-align: center;"> 16 </td> <td> <div id="citation16" class="article-citation"> <b>Shumnalieva R</b>, Kotov G, Ermencheva P, Monov S. Pathogenic Mechanisms and Therapeutic Approaches in Obesity-Related Knee Osteoarthritis. <em class='incite-journal-name' onclick='ShowInCiteJournal(3840);'>Biomedicines</em> 2023;<b>12</b>:9. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38275369' target='_blank'>38275369</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10812969' target='_blank'>PMC10812969</a> DOI: <a href='https://dx.doi.org/10.3390/biomedicines12010009' target='_blank'>10.3390/biomedicines12010009</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3390/biomedicines12010009','38275369', 'cartilage degeneration')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(16);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(16);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3390/biomedicines12010009' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3840);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 11/23/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 12/10/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/14/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/27/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv16" value="10.3390/biomedicines12010009" /> <div style="display: none" id="articleAbstract16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The knee is the joint most frequently involved in osteoarthritis, a common joint disorder in the adult population that is associated with significant chronic joint pain, reduced mobility and quality of life. Recent studies have established an association between obesity and the development of knee osteoarthritis that goes beyond the increased mechanical load on the knees as weight-bearing joints. This link is based on the maintenance of a chronic low-grade inflammation, altered secretion of adipokines by the adipose tissue and development of sarcopenia. Major adipokines involved in the pathogenesis of obesity-related knee osteoarthritis include adiponectin, which appears to have a protective effect, as well as leptin, resistin and visfatin, which are associated with higher pain scores and more severe structural damage. Joint pain in knee osteoarthritis may be both nociceptive and neuropathic and is the result of complex mechanisms driven by nerve growth factor, calcitonin gene-related peptide and pro-inflammatory cytokines. The role of endogenous cannabinoids and gut microbiota in common mechanisms between obesity and knee pain has recently been studied. The aim of the present review is to highlight major pathogenic mechanisms in obesity-related knee osteoarthritis with special attention on pain and to comment on possible therapeutic approaches. </div> <a href="javascript:ShowArticleAbstract(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cartilage+degeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cartilage degeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22molecular+pain+pathway%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">molecular pain pathway</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22osteoarthritis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">osteoarthritis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22pain%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">pain</a></li></ul> <a href="javascript:ShowArticleKeywords(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(16);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow17"> <td style="min-width: 40px; text-align: center;"> 17 </td> <td> <div id="citation17" class="article-citation"> <b>Li Y</b>, Fu T, Zhao Y, Yuan LJ, Wang BB, Guan J, Wang HJ, Li L, Gao YP. Micro-223 Promotes Diabetic Osteoarthritis Progression by Regulating <span class="highlight-field">Cartilage Degeneration</span> and Subchondral Bone Remodeling. <em class='incite-journal-name' onclick='ShowInCiteJournal(4658);'>Cartilage</em> 2023:19476035231210631. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37994560' target='_blank'>37994560</a> DOI: <a href='https://dx.doi.org/10.1177/19476035231210631' target='_blank'>10.1177/19476035231210631</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1177/19476035231210631','37994560', 'cartilage degeneration')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(17);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(17);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1177/19476035231210631' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4658);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://mc.manuscriptcentral.com/cart' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/24/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv17" value="10.1177/19476035231210631" /> <div style="display: none" id="articleAbstract17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">OBJECTIVE</div><div class="abstract-content">Our study was performed to investigate whether micro-223 promotes diabetic Osteoarthritis (OA) progression by regulating cartilage degeneration and subchondral bone remodeling. </div><div class="abstract-label">METHODS</div><div class="abstract-content">The expression of miR-223 in human normal cartilage, OA cartilage, and subchondral bone tissue with or without DM was detected by real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR). miR-223 mimic or inhibitor was transfected into chondrocytes. Cell viability and apoptosis were assessed by 3-(4,5)-dimethylthiahiazo(-2)-3,5-diphenyltetrazolium bromide (MTT) and Terminal Deoxynucleotidyl Transferase(TdT)-mediated dUTP nick end labeling (TUNEL) assay, respectively. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">miR-223 was significantly higher in human diabetic OA cartilage and subchondral bone compared with normal OA and healthy control. Overexpression of miR-223 accelerated cartilage degeneration and subchondral bone sclerosis in diabetic OA mice, whereas miR-223 inhibition had the opposite effect. In vitro upregulation of miR-223 decreased proliferation and enhanced apoptosis of chondrocytes. Meanwhile, downregulation of miR-223 promoted glycosaminoglycan (GAG) production in chondrocytes. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">miR-223 promotes diabetic OA progression by regulating cartilage degeneration and subchondral bone remodeling both in vitro and in vivo. </div> <a href="javascript:ShowArticleAbstract(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cartilage+degeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cartilage degeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22diabetic+osteoarthritis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">diabetic osteoarthritis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22miR-223%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">miR-223</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22subchondral+bone+remodeling%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">subchondral bone remodeling</a></li></ul> <a href="javascript:ShowArticleKeywords(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(17);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow18"> <td style="min-width: 40px; text-align: center;"> 18 </td> <td> <div id="citation18" class="article-citation"> <b>Imamura R</b>, Teramoto A, Murahashi Y, Okada Y, Okimura S, Akatsuka Y, Watanabe K, Yamashita T. Ultra-Short Echo Time-MRI T2* Mapping of Articular Cartilage Layers Is Associated with Histological Early Degeneration. <em class='incite-journal-name' onclick='ShowInCiteJournal(4658);'>Cartilage</em> 2023:19476035231205685. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37846091' target='_blank'>37846091</a> DOI: <a href='https://dx.doi.org/10.1177/19476035231205685' target='_blank'>10.1177/19476035231205685</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1177/19476035231205685','37846091', 'cartilage degeneration')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(18);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(18);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4658);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://mc.manuscriptcentral.com/cart' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/18/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv18" value="10.1177/19476035231205685" /> <div style="display: none" id="articleAbstract18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">OBJECTIVE</div><div class="abstract-content">Ultra-short TE (UTE) sequences on MRI are a technique that improves the visualization of tissues with short T2 relaxation time, such as deep cartilage layers. In addition, T2* relaxation time calculated from the UTE has the potential to evaluate water molecules bound to the cartilage matrix. This study was performed to determine if there is an association between UTE-T2* relaxation time by cartilage layer and histological degeneration in knee osteoarthritis (OA). </div><div class="abstract-label">DESIGN</div><div class="abstract-content">Seven knees that had undergone total knee arthroplasty (TKA) were included in the study, and the lateral tibial cartilage, which had the least degeneration of the resected bones, was used as the sample. The T2* relaxation time of 4 patients with no abnormal findings on MRI was the reference relaxation time. Histological degeneration of TKA samples was assessed by the Mankin score and graded as the early OA group (≤3 points) and the advanced OA group (≥4 points). The association between T2* relaxation time and Mankin grade in each cartilage layer was compared. The effect of angiogenesis to the tidemark on T2* relaxation time was also compared. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">T2* relaxation time of the cartilage layer was significantly longer in early OA than that in the control group. In the deep cartilage layer, the mean T2* relaxation time for angiogenesis (-) was 15.7 ms, whereas it was significantly shorter for angiogenesis (+) at 8.2 ms. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">The UTE-T2* relaxation time was associated with histological cartilage degeneration, suggesting a potential application in monitoring early cartilage degeneration. </div> <a href="javascript:ShowArticleAbstract(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22T2*+relaxation+time%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">T2* relaxation time</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cartilage+degeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cartilage degeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22early+osteoarthritis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">early osteoarthritis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22magnetic+resonance+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">magnetic resonance imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ultra-short+TE%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ultra-short TE</a></li></ul> <a href="javascript:ShowArticleKeywords(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(18);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow19"> <td style="min-width: 40px; text-align: center;"> 19 </td> <td> <div id="citation19" class="article-citation"> <b>Yamamoto M</b>, Hayashi S, Honkura Y, Hirano-Kawamoto A, Katori Y, Murakami G, Rodríguez-Vázquez JF, Abe S. Nasal capsule ossification: A histological study using human foetuses to find an association between the foetus and adult morphologies of the nasal wall. <em class='incite-journal-name' onclick='ShowInCiteJournal(12295);'>J Anat</em> 2023;<b>243</b>:517-533. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/36998216' target='_blank'>36998216</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439375' target='_blank'>PMC10439375</a> DOI: <a href='https://dx.doi.org/10.1111/joa.13867' target='_blank'>10.1111/joa.13867</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1111/joa.13867','36998216', 'cartilage degeneration')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(19);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(19);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(19);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1111/joa.13867' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(12295);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 11/17/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 03/11/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 03/13/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 04/01/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv19" value="10.1111/joa.13867" /> <div style="display: none" id="articleAbstract19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Recent molecular biology studies have revealed the process of nasal capsule determination. We aimed to create a fate map showing the association between the adult and embryonic components of the nasal wall and nasal capsule derivatives. We examined paraffin-embedded histological sections between 15 mid-term (9-16 weeks) and 12 near-term (27-40 weeks) foetuses. Until 15 weeks, membranous ossification occurred 'along' the capsular cartilage, contributing to the formation of the vomer, maxilla and bony nasal septum as well as the nasal, frontal and lacrimal bones. After 15 weeks, a wide lateral part of the capsule became thin and fragmented, and degenerative cartilage was observed near the lacrimal bone, in the three conchae, and at the inferolateral end of the capsule sandwiched between the maxilla and palatine bone. The disappearing cartilages appeared to be replaced by nearby membranous bones. This type of membranous ossification did not appear to use the capsular cartilage as a 'mould', although the perichondrium may have a role in inducing ossification. Calcified cartilage indicated endochondral ossification in the inferior concha until 15 weeks and, later, at the bases of three conchae and around the future sphenoid sinus (i.e. the concha sphenoidalis). The capsular cartilage extended antero-superiorly over the frontal bone and inserted into the nasal bone. At 40 weeks, the capsular cartilage remained in the cribriform plate and at the inferolateral end along the palatine bone. Consequently, less guidance from the nasal capsule seemed to provide great individual variation in the shape of the wide anterolateral wall of the nasal cavity. </div> <a href="javascript:ShowArticleAbstract(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22calcified+cartilage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">calcified cartilage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cartilage+degeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cartilage degeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22human+foetus%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">human foetus</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22nasal+capsule%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">nasal capsule</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ossification%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ossification</a></li></ul> <a href="javascript:ShowArticleKeywords(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteogenesis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteogenesis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nasal+Cavity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nasal Cavity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cartilage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cartilage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fetus%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fetus</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Maxilla%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Maxilla</a></li></ul> <a href="javascript:ShowArticleMeSH(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(19);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow20"> <td style="min-width: 40px; text-align: center;"> 20 </td> <td> <div id="citation20" class="article-citation"> <b>Chen H</b>, Chen F, Hu F, Li Y, Zhang M, Zhou Q, Ding T, Tulufu N, Ye T, Wang F, Guo L. MicroRNA-224-5p nanoparticles balance homeostasis via inhibiting <span class="highlight-field">cartilage degeneration</span> and synovial inflammation for synergistic alleviation of osteoarthritis. <em class='incite-journal-name' onclick='ShowInCiteJournal(337);'>Acta Biomater</em> 2023:S1742-7061(23)00336-7. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37330028' target='_blank'>37330028</a> DOI: <a href='https://dx.doi.org/10.1016/j.actbio.2023.06.010' target='_blank'>10.1016/j.actbio.2023.06.010</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.actbio.2023.06.010','37330028', 'cartilage degeneration')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(20);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(20);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.actbio.2023.06.010' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(337);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/23/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 05/18/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/12/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/19/2023]</span></span> </div> <input type="hidden" name="doiv" id="doiv20" value="10.1016/j.actbio.2023.06.010" /> <div style="display: none" id="articleAbstract20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">MicroRNAs play a crucial role in regulating cartilage extracellular matrix (ECM) metabolism and are being explored as potential therapeutic targets for osteoarthritis (OA). The present study indicated that microRNA-224-5p (miR-224-5p) could balance the homeostasis of OA via regulating cartilage degradation and synovium inflammatory simultaneously. Multifunctional polyamidoamine dendrimer with amino acids used as efficient vector to deliver miR-224-5p. The vector could condense miR-224-5p into transfected nanoparticles, which showed higher cellular uptake and transfection efficiency compared to lipofectamine 3000, and also protected miR-224-5p from RNase degradation. After treatment with the nanoparticles, the chondrocytes showed an increase in autophagy rate and ECM anabolic components, as evidenced by the upregulation of autophagy-related proteins and OA-related anabolic mediators. This led to a corresponding inhibition of cell apoptosis and ECM catabolic proteases, ultimately resulting in the alleviation of ECM degradation. In addition, miR-224-5p also inhibited human umbilical vein endothelial cells angiogenesis and fibroblast-like synoviocytes inflammatory hyperplasia. Integrating the above synergistic effects of miR-224-5p in regulating homeostasis, intra-articular injection of nanoparticles performed outstanding therapeutic effect by reducing articular space width narrowing, osteophyte formation, subchondral bone sclerosis and inhibiting synovial hypertrophy and proliferation in the established mouse OA model. The present study provides a new therapy target and an efficient intra-articular delivery method for improving OA therapy. STATEMENT OF SIGNIFICANCE: Osteoarthritis (OA) is the most prevalent joint disease worldwide. Gene therapy, which involves delivering microRNAs, has the potential to treat OA. In this study, we demonstrated that miR-224-5p can simultaneously regulate cartilage degradation and synovium inflammation, thereby restoring homeostasis in OA gene therapy. Moreover, compared to traditional transfection reagents such as lipofectamine 3000, G5-AHP showed better efficacy in both microRNA transfection and protection against degradation due to its specific surface structure. In summary, G5-AHP/miR-224-5p was developed to meet the clinical needs of OA patients and the high requirement of gene transfection efficiency, providing a promising paradigm for the future application and development of gene therapy.</div> <a href="javascript:ShowArticleAbstract(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22G5-AHP%2fmiR-224-5p+nanoparticles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">G5-AHP/miR-224-5p nanoparticles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cartilage+degeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cartilage degeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22microRNA-224-5p%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">microRNA-224-5p</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22synergistic+alleviation+of+osteoarthritis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">synergistic alleviation of osteoarthritis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22synovial+inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">synovial inflammation</a></li></ul> <a href="javascript:ShowArticleKeywords(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(20);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow21"> <td style="min-width: 40px; text-align: center;"> 21 </td> <td> <div id="citation21" class="article-citation"> <b>Wang W</b>, Duan J, Ma W, Xia B, Liu F, Kong Y, Li B, Zhao H, Wang L, Li K, Li Y, Lu X, Feng Z, Sang Y, Li G, Xue H, Qiu J, Liu H. Trimanganese Tetroxide Nanozyme protects Cartilage against Degeneration by Reducing Oxidative Stress in Osteoarthritis. <em>ADVANCED SCIENCE (WEINHEIM, BADEN-WURTTEMBERG, GERMANY)</em> 2023;<b>10</b>:e2205859. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37088785' target='_blank'>37088785</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265103' target='_blank'>PMC10265103</a> DOI: <a href='https://dx.doi.org/10.1002/advs.202205859' target='_blank'>10.1002/advs.202205859</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1002%2fadvs.202205859%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 20</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1002%2fadvs.202205859')">Impact Index Per Article: 20.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/advs.202205859','37088785', 'cartilage degeneration')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(21);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(21);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(21);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(21);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1002/advs.202205859' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/09/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 03/12/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 05/03/2023]</span></span> </div> <input type="hidden" name="doiv" id="doiv21" value="10.1002/advs.202205859" /> <div style="display: none" id="articleAbstract21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Osteoarthritis, a chronic degenerative cartilage disease, is the leading cause of movement disorders among humans. Although the specific pathogenesis and associated mechanisms remain unclear, oxidative stress-induced metabolic imbalance in chondrocytes plays a crucial role in the occurrence and development of osteoarthritis. In this study, a trimanganese tetroxide (Mn3 O4 ) nanozyme with superoxide dismutase (SOD)-like and catalase (CAT)-like activities is designed to reduce oxidative stress-induced damage and its therapeutic effect is investigated. In vitro, Mn3 O4 nanozymes are confirmed to reprogram both the imbalance of metabolism in chondrocytes and the uncontrolled inflammatory response stimulated by hydrogen peroxide. In vivo, a cross-linked chondroitin sulfate (CS) hydrogel is designed as a substrate for Mn3 O4 nanozymes to treat osteoarthritis in mouse models. As a result, even in the early stage of OA (4 weeks), the therapeutic effect of the Mn3 O4 @CS hydrogel is observed in both cartilage metabolism and inflammation. Moreover, the Mn3 O4 @CS hydrogel maintained its therapeutic effects for at least 7 days, thus revealing a broad scope for future clinical applications. In conclusion, these results suggest that the Mn3 O4 @CS hydrogel is a potentially effective therapeutic treatment for osteoarthritis, and a novel therapeutic strategy for osteoarthritis based on nanozymes is proposed. </div> <a href="javascript:ShowArticleAbstract(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cartilage+degeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cartilage degeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cartilage+metabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cartilage metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22osteoarthritis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">osteoarthritis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22trimanganese+tetroxide+nanozymes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">trimanganese tetroxide nanozymes</a></li></ul> <a href="javascript:ShowArticleKeywords(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cartilage%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cartilage/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoarthritis%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoarthritis/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoarthritis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoarthritis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+Stress%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative Stress</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidation-Reduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidation-Reduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chondrocytes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chondrocytes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chondrocytes%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chondrocytes/pathology</a></li></ul> <a href="javascript:ShowArticleMeSH(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant21" class="article-abstract"> <b style="display: block; 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text-align: center;"> 22 </td> <td> <div id="citation22" class="article-citation"> <b>Valluru PKR</b>, Su A, Mehta S, Bajpayee A, Shefelbine S. Spatial and Temporal Mapping of Articular Cartilage Poro-Viscoelastic Material Properties Using Indentation. <em class='incite-journal-name' onclick='ShowInCiteJournal(13193);'>J Biomech Eng</em> 2023;<b>145</b>:1151022. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/36416287' target='_blank'>36416287</a> DOI: <a href='https://dx.doi.org/10.1115/1.4056294' target='_blank'>10.1115/1.4056294</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1115/1.4056294','36416287', 'cartilage degeneration')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(22);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(22);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1115/1.4056294' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(13193);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/14/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/16/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/24/2022]</span></span> </div> <input type="hidden" name="doiv" id="doiv22" value="10.1115/1.4056294" /> <div style="display: none" id="articleAbstract22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Biphasic poro-viscoelastic constitutive material model (BPVE) captures both the fluid flow dependent and independent behavior of cartilage under stress relaxation type indentation. A finite element model based on BPVE formulation was developed to explore the sensitivity of the model to Young's modulus, Poisson's ratio, permeability, and viscoelastic constitutive parameters expressed in terms of Prony series coefficients. Then we fit the numerical model to experimental force versus time curves from stress relaxation indents on bovine tibial plateaus to extract the material properties. Measurements were made over the period of two days to capture the material property changes that resulted from trypsin-induced degradation. We measured spatial and temporal changes in mechanical properties in the cartilage. The areas of degradation were characterized by an increase in both permeability and summation of Prony series shear relaxation amplitude constants. These findings suggest that cartilage degradation reduces the intrinsic viscoelastic properties of the solid phase of the tissue in addition to impairing its capacity to offer frictional drag to the interstitial fluid flow (permeability). The changes in material properties are measurable well before structural degradation occurs.</div> <a href="javascript:ShowArticleAbstract(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22articular+cartilage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">articular cartilage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22biphasic+poro-viscoelastic+material+model%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">biphasic poro-viscoelastic material model</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cartilage+degeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cartilage degeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22indentation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">indentation</a></li></ul> <a href="javascript:ShowArticleKeywords(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(22);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow23"> <td style="min-width: 40px; text-align: center;"> 23 </td> <td> <div id="citation23" class="article-citation"> <b>Yan W</b>, Fan Y, Dai W, Cheng J, Zhao F, Yang S, Li Y, Maimaitimin M, Cao C, Shao Z, Li Z, Wang H, Hu X, Ao Y. Earlier and More Severe <span class="highlight-field">Cartilage Degeneration</span> Occurs After Meniscal Tears in Juvenile Rabbits Compared with Adults. <em class='incite-journal-name' onclick='ShowInCiteJournal(4658);'>Cartilage</em> 2023;<b>14</b>:106-118. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/36444115' target='_blank'>36444115</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076899' target='_blank'>PMC10076899</a> DOI: <a href='https://dx.doi.org/10.1177/19476035221138959' target='_blank'>10.1177/19476035221138959</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1177/19476035221138959','36444115', 'cartilage degeneration')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(23);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(23);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(23);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1177/19476035221138959' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4658);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://mc.manuscriptcentral.com/cart' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/03/2022]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv23" value="10.1177/19476035221138959" /> <div style="display: none" id="articleAbstract23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">OBJECTIVE</div><div class="abstract-content">To compare the severity of cartilage degeneration after meniscal tears between juvenile and adult rabbits.</div><div class="abstract-label">DESIGN</div><div class="abstract-content">This study included 20 juvenile rabbits (2 weeks after birth) and 20 adult rabbits (6 months after birth). Meniscal tears were prepared in the anterior horn of medial menisci of right knees. Rabbits were sacrificed at 1, 3, 6, and 12 weeks postoperatively. Cartilage degenerations in the medial femoral condyle and medial tibial plateau were evaluated macroscopically and histologically. The semiquantitative assessment of cartilage degeneration was graded by macroscopic Outerbridge scoring system and histological Osteoarthritis Research Society International (OARSI) scoring system.</div><div class="abstract-label">RESULTS</div><div class="abstract-content">In juvenile rabbits, the morphologically intact cartilage and normal extracellular matrix architecture were observed at the first week postoperatively. Mild uneven cartilage surface and toluidine blue depletion in the medial femoral condyle were observed on histological assessment at 3 weeks postoperatively. The worsened cartilage deterioration demonstrating chondral fibrillation, prominent cell death, and glycosaminoglycan (GAG) release was observed at 6 and 12 weeks postoperatively. In adult rabbits, only mild cartilage degeneration was observed in the medial femoral condyle at 12 weeks postoperatively. The outcomes of Outerbridge and OARSI scores were consistent with the aforementioned findings in juvenile and adult rabbits.</div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">Our study validated that earlier and more severe cartilage degenerations were observed in juvenile rabbits after meniscal tears compared with adult rabbits. Moreover, the post-tear cartilage degeneration demonstrated regional specificity corresponded to the tear position. However, caution is warranted when extrapolating results of animal models to humans.</div> <a href="javascript:ShowArticleAbstract(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cartilage+degeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cartilage degeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22juvenile%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">juvenile</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22meniscal+tear%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">meniscal tear</a></li></ul> <a href="javascript:ShowArticleKeywords(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rabbits%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rabbits</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Knee+Joint%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Knee Joint/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cartilage+Diseases%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cartilage Diseases/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Knee+Injuries%2fsurgery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Knee Injuries/surgery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Menisci%2c+Tibial%2fsurgery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Menisci, Tibial/surgery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Menisci%2c+Tibial%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Menisci, Tibial/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tibia%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tibia/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoarthritis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoarthritis/pathology</a></li></ul> <a href="javascript:ShowArticleMeSH(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(23);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow24"> <td style="min-width: 40px; text-align: center;"> 24 </td> <td> <div id="citation24" class="article-citation"> <b>Lange T</b>, Sturm L, Jungmann PM, Jung M, Ovsepyan S, Reisert M, Schmal H, Wenning M. Biomechanical Effects of Chronic Ankle Instability on the Talar Cartilage Matrix: The Value of T1ρ Relaxation Mapping Without and With Mechanical Loading. <em class='incite-journal-name' onclick='ShowInCiteJournal(169294);'>J Magn Reson Imaging</em> 2023;<b>57</b>:611-619. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/35611813' target='_blank'>35611813</a> DOI: <a href='https://dx.doi.org/10.1002/jmri.28267' target='_blank'>10.1002/jmri.28267</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1002%2fjmri.28267%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 1</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1002%2fjmri.28267')">Impact Index Per Article: 1.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/jmri.28267','35611813', 'cartilage degeneration')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(24);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(24);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1002/jmri.28267' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(169294);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/08/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 05/10/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 05/11/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/20/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv24" value="10.1002/jmri.28267" /> <div style="display: none" id="articleAbstract24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">T1ρ mapping has been proposed for the detection of early cartilage degeneration associated with chronic ankle instability (CAI). However, there are limited data surrounding the influence of ankle loading on T1ρ relaxation.</div><div class="abstract-label">PURPOSE</div><div class="abstract-content">To evaluate T1ρ relaxation times of talar cartilage, as an indicator of early degenerative changes, associated with CAI and to investigate the influence of acute axial in situ loading on T1ρ values in CAI patients and healthy controls.</div><div class="abstract-label">STUDY TYPE</div><div class="abstract-content">Prospective.</div><div class="abstract-label">SUBJECTS</div><div class="abstract-content">A total of 9 patients (age = 21.8 ± 2.5 years, male/female = 2/7) with chronic ankle instability and 18 healthy control subjects (age = 22.8 ± 3.6 years, male/female = 5/13).</div><div class="abstract-label">FIELD STRENGTH</div><div class="abstract-content">3 T.</div><div class="abstract-label">SEQUENCE</div><div class="abstract-content">3D gradient echo fast low-angle shot (FLASH) sequence augmented with a variable spin-lock preparation period.</div><div class="abstract-label">ASSESSMENT</div><div class="abstract-content">Ankle T1ρ mapping was performed without and with axial loading of 500 N. The talar cartilage was segmented in five coronal slices covering the central talocrural joint. Median talar T1ρ values were separately calculated for the medial and lateral facets.</div><div class="abstract-label">STATISTICAL TESTS</div><div class="abstract-content">Mann-Whitney U and Wilcoxon signed-rank tests, significance level: P < 0.05.</div><div class="abstract-label">RESULTS</div><div class="abstract-content">For the combined cohorts, the statistical analysis yielded significantly lower T1ρ values with loading compared to the no-load measurement for both the lateral (no load: [51.0 ± 4.0] msec, load: [49.5 ± 5.4] msec) as well as the medial compartment (no load: [50.0 ± 5.4] msec, load: [47.8 ± 6.8] msec). In the unloaded scans, the CAI patients showed significantly increased talar T1ρ values ([53.0 ± 7.4] mse ) compared to the healthy control subjects ([48.8 ± 4.1] msec) in the medial compartment.</div><div class="abstract-label">DATA CONCLUSION</div><div class="abstract-content">Increased talar T1ρ relaxation times in CAI patients compared to healthy controls suggest that T1ρ relaxation is a sensitive biomarker for CAI-induced early-stage cartilage degeneration. However, the load-induced T1ρ change did not prove to be a viable marker for the altered biomechanical properties of the hyaline talar cartilage.</div><div class="abstract-label">LEVEL OF EVIDENCE</div><div class="abstract-content">2 LEVEL OF EFFICACY: Stage 2.</div> <a href="javascript:ShowArticleAbstract(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22T1%cf%81+relaxation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">T1ρ relaxation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cartilage+degeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cartilage degeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22chronic+ankle+instability%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">chronic ankle instability</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22in+situ+loading%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">in situ loading</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22magnetic+resonance+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">magnetic resonance imaging</a></li></ul> <a href="javascript:ShowArticleKeywords(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(24);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow25"> <td style="min-width: 40px; text-align: center;"> 25 </td> <td> <div id="citation25" class="article-citation"> <b>Liu Q</b>, Hao H, Li J, Zheng T, Yao Y, Tian X, Zhang Z, Yi H. Oral Administration of Bovine Milk-Derived Extracellular Vesicles Attenuates <span class="highlight-field">Cartilage Degeneration</span> via Modulating Gut Microbiota in DMM-Induced Mice. <em class='incite-journal-name' onclick='ShowInCiteJournal(18223);'>Nutrients</em> 2023;<b>15</b>:nu15030747. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/36771453' target='_blank'>36771453</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9920331' target='_blank'>PMC9920331</a> DOI: <a href='https://dx.doi.org/10.3390/nu15030747' target='_blank'>10.3390/nu15030747</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.3390%2fnu15030747%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 6</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.3390%2fnu15030747')">Impact Index Per Article: 6.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3390/nu15030747','36771453', 'cartilage degeneration')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(25);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(25);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(25);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3390/nu15030747' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.3390/nu15030747');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(18223);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/10/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 01/26/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 01/28/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 02/05/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv25" value="10.3390/nu15030747" /> <div style="display: none" id="articleAbstract25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Osteoarthritis (OA) is the most common joint disease primarily characterized by cartilage degeneration. Milk-derived extracellular vesicles (mEVs) were reported to inhibit catabolic and inflammatory processes in the cartilage of OA patients. However, the current therapies target the advanced symptoms of OA, and it is significant to develop a novel strategy to inhibit the processes driving OA pathology. In this study, we investigated the therapeutic potential of mEVs in alleviating OA in vivo. The results revealed that mEVs ameliorated cartilage degeneration by increasing hyaline cartilage thickness, decreasing histological Osteoarthritis Research Society International (OARSI) scores, enhancing matrix synthesis, and reducing the expression of cartilage destructive enzymes in the destabilization of medial meniscus (DMM) mice. In addition, the disturbed gut microbiota in DMM mice was partially improved upon treatment with mEVs. It was observed that the pro-inflammatory bacteria (<i>Proteobacteria</i>) were reduced and the potential beneficial bacteria (<i>Firmicutes</i>, <i>Ruminococcaceae</i>, <i>Akkermansiaceae</i>) were increased. mEVs could alleviate the progression of OA by restoring matrix homeostasis and reshaping the gut microbiota. These findings suggested that mEVs might be a potential therapeutic dietary supplement for the treatment of OA.</div> <a href="javascript:ShowArticleAbstract(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22bovine+milk%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">bovine milk</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cartilage+degeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cartilage degeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22extracellular+vesicles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">extracellular vesicles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22gut+microbiota%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">gut microbiota</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22osteoarthritis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">osteoarthritis</a></li></ul> <a href="javascript:ShowArticleKeywords(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Menisci%2c+Tibial%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Menisci, Tibial/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Menisci%2c+Tibial%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Menisci, Tibial/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chondrocytes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chondrocytes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Milk%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Milk/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Microbiome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Microbiome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoarthritis%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoarthritis/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Extracellular+Vesicles%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Extracellular Vesicles/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Administration%2c+Oral%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Administration, Oral</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cartilage%2c+Articular%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cartilage, Articular/pathology</a></li><li><a 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dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_chartPopupControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_chartPopupControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_420552910" type="text/javascript">  </script> <div id="RootHolder_pcImportArticlesControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:50px;width:50px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_pcImportArticlesControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Import Articles</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="RootHolder_pcImportArticlesControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcImportArticlesControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcImportArticlesControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcImportArticlesControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_365297802" type="text/javascript">  </script> <div id="RootHolder_pcEditArticleControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_pcEditArticleControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Edit My Journal Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content" style="overflow-x:hidden;overflow-y:scroll;">    </div> </div> </div> </div><div id="RootHolder_pcEditArticleControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcEditArticleControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcEditArticleControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcEditArticleControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_298765222" type="text/javascript">  </script> <div id="RootHolder_userIndexComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:400px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Article Influence Index</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle2">Article Influence Index</span></b> </p> <p> Total Citations in Crossref ÷ Total Articles = <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle3">Article Influence Index</span><sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="RootHolder_userIndexComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_userIndexComputePopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_userIndexComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1286575841" type="text/javascript">  </script> <div id="RootHolder_articleExportPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:280px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow" style="font-size:11pt;"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_articleExportPopup_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Export Articles to File</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="dxtcLite_MetropolisBlue dxtcSys dxtc-init dxtc-top dxtc-pc" id="RootHolder_articleExportPopup_ExportFilePageControl" style="width:100%;"> <ul class="dxtc-strip dxtc-row dxtc-stripContainer"> <li class="dxtc-leftIndent"> </li><li class="dxtc-tab dxtc-lead" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-activeTab dxtc-lead"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-spacer"> </li><li class="dxtc-tab dxtc-last"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-activeTab dxtc-last" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-rightIndent"> </li> </ul><div class="dxtc-content"> <div> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_SearchTermText1">cartilage degeneration (119 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:5px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_1662381219" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailEndIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" value="119" type="text" /></td> </tr> </table><script id="dxss_616434442" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_1167331127" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_54524200" type="text/javascript">  </script><script id="dxss_1678130197" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" style="font-weight:bold;">JCR Year:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" type="hidden" value="2023" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" value="2023" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2023</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2022</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2021</td> </tr> </table> </div></td> </tr> </table><script id="dxss_830317689" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_167955898" type="text/javascript">  </script><script id="dxss_2013408041" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1062639383" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_104403608" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1973673553" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_6" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLTSys dxflItemSys dxflCheckBoxWithTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" style="font-weight:bold;">Record Content:</label></td> </tr><tr> <td class="dxflNestedControlCell_MetropolisBlue"> <table> <tr> <td style="vertical-align: middle; padding: 5px;"> <table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields" style="color:#BD4100;"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$cbSelectAllFields" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label>Select All Fields</label></td> </tr> </table><script id="dxss_1176833720" type="text/javascript">  </script> </td> </tr> <tr> <td style="padding: 5px;"> <table class="dxeCheckBoxList_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields" style="width:100%;border-collapse:separate;"> <tr> <td class="dxe"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields" /><table style="width:100%;"> <tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB0" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Author(s)</label></td> </tr> </table><script id="dxss_771536870" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB1" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Title</label></td> </tr> </table><script id="dxss_1086331335" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB2" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Keywords</label></td> </tr> </table><script id="dxss_1308541020" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB3" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">MESH Headings</label></td> </tr> </table><script id="dxss_896786043" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB4" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Journal Title</label></td> </tr> </table><script id="dxss_450242410" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB5" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Year</label></td> </tr> </table><script id="dxss_765036875" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB6" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Type</label></td> </tr> </table><script id="dxss_1629835480" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB7" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Language</label></td> </tr> </table><script id="dxss_1218080503" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB8" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Published Date</label></td> </tr> </table><script id="dxss_1428514578" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB9" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author</label></td> </tr> </table><script id="dxss_1113720113" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB10" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author’s Affiliations</label></td> </tr> </table><script id="dxss_310841941" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB11" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author</label></td> </tr> </table><script id="dxss_1301541094" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB12" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author’s Affiliations</label></td> </tr> </table><script id="dxss_675718561" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB13" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Email</label></td> </tr> </table><script id="dxss_2006865700" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB14" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">All Authors's Affiliations</label></td> </tr> </table><script id="dxss_1204905793" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB15" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Grant</label></td> </tr> </table><script id="dxss_407477242" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB16" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">ISSN</label></td> </tr> </table><script id="dxss_218345291" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB17" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Publisher</label></td> </tr> </table><script id="dxss_1394037744" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB18" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexing / Abstracting</label></td> </tr> </table><script id="dxss_319681069" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB19" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">2023 Impact Factor</label></td> </tr> </table><script id="dxss_1292701966" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB20" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">2023 JCR Quartile</label></td> </tr> </table><script id="dxss_1844280938" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB21" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Index Per Article</label></td> </tr> </table><script id="dxss_838303323" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB22" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Category</label></td> </tr> </table><script id="dxss_1464125856" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB23" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Times Cited in RCA</label></td> </tr> </table><script id="dxss_148257179" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB24" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Peer-Reviewed Journal</label></td> </tr> </table><script id="dxss_950217086" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB25" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Open Access</label></td> </tr> </table><script id="dxss_1732367175" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB26" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">DOI</label></td> </tr> </table><script id="dxss_1936777588" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB27" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">PMID</label></td> </tr> </table><script id="dxss_745806673" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB28" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Citation</label></td> </tr> </table><script id="dxss_1835441810" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB29" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexed in RCA</label></td> </tr> </table><script id="dxss_847142451" type="text/javascript">  </script></td><td></td><td></td> </tr> </table></td> </tr> </table><script id="dxss_427463133" type="text/javascript">  </script> </td> </tr> </table> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_7" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportedDetailFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_1198171345" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_1960175520" type="text/javascript">  </script> </div> </div><div style="display:none;"> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_SearchTermText2">cartilage degeneration (119 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:10px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_814491935" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportEndSIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" value="119" type="text" /></td> </tr> </table><script id="dxss_1331245653" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:10px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_2046065225" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_1926633208" type="text/javascript">  </script><script id="dxss_228619664" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:20px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" type="hidden" value="1" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" value="Excel" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1509722775" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_960798088" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_835950349" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportedFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_308093146" 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All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA </div> <div class="scroll"> <a href="#top" target="_self"> <img src="/Contents/Images/backtop3.png" /> </a> </div> <div id="categorySelectorPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Select the Category</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="categorySelectorPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="categorySelectorPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="categorySelectorPopup_TL">Loading…</span></td> </tr> </table><div id="categorySelectorPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_166253781" type="text/javascript">  </script> <div id="pcLoginPopUp_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:700px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="pcLoginPopUp_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="pcLoginPopUp_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="pcLoginPopUp_TL">Loading…</span></td> </tr> </table><div id="pcLoginPopUp_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_430910140" type="text/javascript">  </script> <div id="aiComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:300px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Impact Index Per Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for Impact Index Per Article</b> </p> <p> Times Cited ÷ Number of Years = Impact Index Per Article<sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="aiComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="aiComputePopup_TL">Loading…</span></td> </tr> </table><div id="aiComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_698179129" type="text/javascript">  </script> <script type="text/javascript"> //<![CDATA[ var callBackFrameUrl='/WebResource.axd?d=beToSAE3vdsL1QUQUxjWdX-3aFLejnBliGvqSCZYULGFdxZmRlcJcqs71AKVNTQEXljNmd0slFkUZ_AFaCke4Q2&t=638628207619783110'; WebForm_InitCallback();//]]> </script> </form> </body> </html>