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Torres-Ruiz</span><sup>1</sup></span>, <span style="white-space:nowrap;"><span itemprop=author>I. Pinal-Fernandez</span><sup>2</sup></span>, <span style="white-space:nowrap;"><span itemprop=author>A. Selva-O'callaghan</span><sup>3</sup></span>, <span style="white-space:nowrap;"><span itemprop=author>B. Campbell</span><sup>4</sup></span>, <span style="white-space:nowrap;"><span itemprop=author>S. Muñoz-Braceras</span><sup>5</sup></span>, <span style="white-space:nowrap;"><span itemprop=author>N.R. Mejía-Domínguez</span><sup>6</sup></span>, <span style="white-space:nowrap;"><span itemprop=author>C. Núñez-Álvarez</span><sup>7</sup></span>, <span style="white-space:nowrap;"><span itemprop=author>J. Milisenda</span><sup>8</sup></span>, <span style="white-space:nowrap;"><span itemprop=author>M. Casal-Domínguez</span><sup>9</sup></span>, <span style="white-space:nowrap;"><span itemprop=author>K. Pak</span><sup>10</sup></span>, <span style="white-space:nowrap;"><span itemprop=author>A. Guillén-Del-Castillo</span><sup>11</sup></span>, <span style="white-space:nowrap;"><span itemprop=author>E. Trallero-Araguas</span><sup>12</sup></span>, <span style="white-space:nowrap;"><span itemprop=author>A. Gil-Vila</span><sup>13</sup></span>, <span style="white-space:nowrap;"><span itemprop=author>A.L. Mammen</span><sup>14</sup></span></p><div style="heigth=100px;width=100%;line-height:3px;display:block;margin:27px 0;border-bottom:3px solid #333; border-top:1px solid #333"> </div><div class=row><div class="col-md-3 col-xs-12"><p><a data-toggle=collapse href='#authlist' aria-expanded=false aria-controls=authlist><span class='bi bi-plus-circle'></span> Author information</a></p><div class=collapse id=authlist><ol><li>Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, and Muscle Disease Unit, Laboratory of Muscle Stem Cells and Gene Regulations, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.</li><li>Muscle Disease Unit, Laboratory of Muscle Stem Cells and Gene Regulations, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, and Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.</li><li>Systemic Autoimmune Disease Unit, Vall d’Hebron Research Institute, Barcelona, and Universitat Autonoma de Barcelona, Spain.</li><li>Muscle Disease Unit, Laboratory of Muscle Stem Cells and Gene Regulations, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, and Howard University College of Medicine, Washington DC, USA.</li><li>Muscle Disease Unit, Laboratory of Muscle Stem Cells and Gene Regulations, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.</li><li>Red de Apoyo a la Investigación, Coordinación de Investigación Científica, Universidad Nacional Autónoma de México, Mexico City, Mexico.</li><li>Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.</li><li>Muscle Disease Unit, Laboratory of Muscle Stem Cells and Gene Regulations, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA, and Muscle Research Unit, Internal Medicine Service, Hospital Clínic de Barcelona, Universidad de Barcelona and CIBERER, Barcelona, Spain.</li><li>Muscle Disease Unit, Laboratory of Muscle Stem Cells and Gene Regulations, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.</li><li>Muscle Disease Unit, Laboratory of Muscle Stem Cells and Gene Regulations, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.</li><li>Systemic Autoimmune Disease Unit, Vall d’Hebron Research Institute, Barcelona, Spain.</li><li>Rheumatology Department, Vall d’Hebron Research Institute, Barcelona, Spain.</li><li>Systemic Autoimmune Disease Unit, Vall d’Hebron Research Institute, Barcelona, Spain.</li><li>Muscle Disease Unit, Laboratory of Muscle Stem Cells and Gene Regulations, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore; and Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. andrew.mammen@nih.gov</li></ol></div><p><b>CER17234</b><br><a href='a.asp?IDArchivio=287'>2024 Vol.42, N°2</a><br><abbr title='Initial Page'>PI </abbr> 0367, <abbr title='Final Page'>PF </abbr> 0376<br><em itemprop=articleSection>Diagnosis</em></p><p><span class=arancio>Free to view</span><br><small>(click on article PDF icon to read the article)</small></p><p>PMID: <a href='https://www.ncbi.nlm.nih.gov/pubmed/38488092' title='Pubmed::View' target=_blank rel=noopener>38488092</a> [PubMed]</p><p><small>Received: <meta itemprop=dateCreated content="2023-10-24">24/10/2023<br>Accepted : <meta itemprop=dateModified content="2024-02-01">01/02/2024<br>In Press: 14/03/2024<br>Published: <meta itemprop=datePublished content="2024-03-14">14/03/2024</small></p><div class=text-center><canvas id=xqrcode style="display:block;max-width:100%;height:auto;"></canvas></div></div><div class="col-md-8 col-xs-12"><h2 style="border:0;background:none;padding:0;font-weight:600;margin-top:0">Abstract</h2><p><b>OBJECTIVES:</b><br> To assess nailfold video capillaroscopic (NVC) abnormalities and their association with clinical features, myositis-specific autoantibodies (MSA), and myositis-associated antibodies (MAA) in a large multi-ethnic cohort of patients with idiopathic inflammatory myopathies (IIM). <br><b>METHODS:</b><br> We recruited 155 IIM patients from three centres in Mexico, Spain, and the USA. We evaluated the clinical and laboratory features of the patients and performed semiquantitative and quantitative analyses of the NVC. Each NVC study was defined as having a normal, non-specific, early systemic sclerosis (SSc), active SSc, or late SSc pattern. Twenty-three patients had at least one follow-up NVC when disease control was achieved. Quantitative variables were expressed as medians and interquartile range (IQR) and were compared with the Kruskal-Wallis, the Mann-Whitney U-test, and the Wilcoxon test for paired medians. Associations between qualitative variables were assessed with the χ2 test. <br><b>RESULTS:</b><br> Most patients were women (68.3%), Hispanic (73.5%), and had dermatomyositis (DM) (61.2%). Fourteen patients (9%) had a normal NVC. A non-specific abnormality pattern was the most frequent (53.9%), and was associated with joint involvement, interstitial lung disease, Jo1 autoantibodies, anti-synthetase syndrome, and immune-mediated necrotising myopathy. The SSc pattern was observed mostly in DM and overlap myositis and was associated with cutaneous features and anti-TIF-1g autoantibodies. After treatment, there was a decrease in the capillaroscopic score, the capillary diameter, and the number of avascular areas, and an increase in capillary density and bushy capillary number. <br><b>CONCLUSIONS:</b><br> NVC abnormalities are related to the diagnosis, clinical features, disease activity, and autoantibodies of patients with IIM.</p><p>DOI: <a href="https://doi.org/10.55563/clinexprheumatol/l9gudh" title="DOI" target=_blank rel=noopener>https://doi.org/10.55563/clinexprheumatol/l9gudh</a></p></div><div class="col-md-1 col-xs-12"><p><a href='/article.asp?a=20487' title="Download PDF" target=_blank><img src='/obj/image/ico/30pdf.png' width=150 height=150 alt="Rheumatology Article" style="max-width:50px" class=img-responsive loading=lazy></a></p></div></div></div><div class=clearfix></div></main><footer><div id=footer-post><div class="container hidden-print"><div class=row><div class=col-md-6><p>© Clinical and Experimental Rheumatology<br>(Journal with On line 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