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class="vector-dropdown-checkbox " aria-label="Aspetto" > <label id="vector-appearance-dropdown-label" for="vector-appearance-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-appearance mw-ui-icon-wikimedia-appearance"></span> <span class="vector-dropdown-label-text">Aspetto</span> </label> <div class="vector-dropdown-content"> <div id="vector-appearance-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <div id="p-vector-user-menu-notifications" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <div id="p-vector-user-menu-overflow" class="vector-menu mw-portlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-sitesupport-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="//donate.wikimedia.org/wiki/Special:FundraiserRedirector?utm_source=donate&utm_medium=sidebar&utm_campaign=C13_it.wikipedia.org&uselang=it" class=""><span>Fai una donazione</span></a> </li> <li id="pt-createaccount-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=Speciale:CreaUtenza&returnto=Diazossido" title="Si consiglia di registrarsi e di effettuare l'accesso, anche se non è obbligatorio" class=""><span>registrati</span></a> </li> <li id="pt-login-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=Speciale:Entra&returnto=Diazossido" title="Si consiglia di effettuare l'accesso, anche se non è obbligatorio [o]" accesskey="o" class=""><span>entra</span></a> </li> </ul> </div> </div> </div> <div id="vector-user-links-dropdown" class="vector-dropdown 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mw-portlet-user-menu-anon-editor" > <div class="vector-menu-heading"> Pagine per utenti anonimi <a href="/wiki/Aiuto:Benvenuto" aria-label="Ulteriori informazioni sulla contribuzione"><span>ulteriori informazioni</span></a> </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-anoncontribs" class="mw-list-item"><a href="/wiki/Speciale:MieiContributi" title="Un elenco delle modifiche fatte da questo indirizzo IP [y]" accesskey="y"><span>contributi</span></a></li><li id="pt-anontalk" class="mw-list-item"><a href="/wiki/Speciale:MieDiscussioni" title="Discussioni sulle modifiche fatte da questo indirizzo IP [n]" accesskey="n"><span>discussioni</span></a></li> </ul> </div> </div> </div> </div> </nav> </div> </header> </div> <div class="mw-page-container"> <div class="mw-page-container-inner"> <div class="vector-sitenotice-container"> <div id="siteNotice"></div> </div> <div class="vector-column-start"> <div class="vector-main-menu-container"> <div id="mw-navigation"> <nav id="mw-panel" class="vector-main-menu-landmark" aria-label="Sito"> <div id="vector-main-menu-pinned-container" class="vector-pinned-container"> </div> </nav> </div> </div> <div class="vector-sticky-pinned-container"> <nav id="mw-panel-toc" aria-label="Indice" data-event-name="ui.sidebar-toc" class="mw-table-of-contents-container vector-toc-landmark"> <div id="vector-toc-pinned-container" class="vector-pinned-container"> <div id="vector-toc" class="vector-toc vector-pinnable-element"> <div class="vector-pinnable-header vector-toc-pinnable-header vector-pinnable-header-pinned" data-feature-name="toc-pinned" data-pinnable-element-id="vector-toc" > <h2 class="vector-pinnable-header-label">Indice</h2> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-toc.pin">sposta nella barra laterale</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-toc.unpin">nascondi</button> </div> <ul class="vector-toc-contents" id="mw-panel-toc-list"> <li id="toc-mw-content-text" class="vector-toc-list-item vector-toc-level-1"> <a href="#" class="vector-toc-link"> <div class="vector-toc-text">Inizio</div> </a> </li> <li id="toc-Caratteristiche_strutturali_e_fisiche" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Caratteristiche_strutturali_e_fisiche"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>Caratteristiche strutturali e fisiche</span> </div> </a> <ul id="toc-Caratteristiche_strutturali_e_fisiche-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Farmacodinamica" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Farmacodinamica"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Farmacodinamica</span> </div> </a> <ul id="toc-Farmacodinamica-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Farmacocinetica" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Farmacocinetica"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Farmacocinetica</span> </div> </a> <ul id="toc-Farmacocinetica-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Tossicologia" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Tossicologia"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Tossicologia</span> </div> </a> <ul id="toc-Tossicologia-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Usi_clinici" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Usi_clinici"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Usi clinici</span> </div> </a> <ul id="toc-Usi_clinici-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Effetti_collaterali_e_indesiderati" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Effetti_collaterali_e_indesiderati"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>Effetti collaterali e indesiderati</span> </div> </a> <ul id="toc-Effetti_collaterali_e_indesiderati-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Dosi_terapeutiche" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Dosi_terapeutiche"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>Dosi terapeutiche</span> </div> </a> <ul id="toc-Dosi_terapeutiche-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Interazioni" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Interazioni"> <div class="vector-toc-text"> <span class="vector-toc-numb">8</span> <span>Interazioni</span> </div> </a> <ul id="toc-Interazioni-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Note" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Note"> <div class="vector-toc-text"> <span class="vector-toc-numb">9</span> <span>Note</span> </div> </a> <ul id="toc-Note-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Bibliografia" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Bibliografia"> <div class="vector-toc-text"> <span class="vector-toc-numb">10</span> <span>Bibliografia</span> </div> </a> <ul id="toc-Bibliografia-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Altri_progetti" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Altri_progetti"> <div class="vector-toc-text"> <span class="vector-toc-numb">11</span> <span>Altri progetti</span> </div> </a> <ul id="toc-Altri_progetti-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Indice" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Mostra/Nascondi l'indice" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Mostra/Nascondi l'indice</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Diazossido</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Vai a una voce in un'altra lingua. Disponibile in 21 lingue" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-21" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">21 lingue</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%AF%D9%8A%D8%A7%D8%B2%D9%88%D9%83%D8%B3%D9%8A%D8%AF" title="ديازوكسيد - arabo" lang="ar" hreflang="ar" data-title="ديازوكسيد" data-language-autonym="العربية" data-language-local-name="arabo" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-azb mw-list-item"><a href="https://azb.wikipedia.org/wiki/%D8%AF%DB%8C%D8%A7%D8%B2%D9%88%DA%A9%D8%B3%D8%A7%DB%8C%D8%AF" title="دیازوکساید - South Azerbaijani" lang="azb" hreflang="azb" data-title="دیازوکساید" data-language-autonym="تۆرکجه" data-language-local-name="South Azerbaijani" class="interlanguage-link-target"><span>تۆرکجه</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Diaz%C3%B2xid" title="Diazòxid - catalano" lang="ca" hreflang="ca" data-title="Diazòxid" data-language-autonym="Català" data-language-local-name="catalano" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-cy mw-list-item"><a href="https://cy.wikipedia.org/wiki/Diasocsid" title="Diasocsid - gallese" lang="cy" hreflang="cy" data-title="Diasocsid" data-language-autonym="Cymraeg" data-language-local-name="gallese" class="interlanguage-link-target"><span>Cymraeg</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Diazoxid" title="Diazoxid - tedesco" lang="de" hreflang="de" data-title="Diazoxid" data-language-autonym="Deutsch" data-language-local-name="tedesco" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Diazoxide" title="Diazoxide - inglese" lang="en" hreflang="en" data-title="Diazoxide" data-language-autonym="English" data-language-local-name="inglese" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Diaz%C3%B3xido" title="Diazóxido - spagnolo" lang="es" hreflang="es" data-title="Diazóxido" data-language-autonym="Español" data-language-local-name="spagnolo" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-eu mw-list-item"><a href="https://eu.wikipedia.org/wiki/Diazoxido" title="Diazoxido - basco" lang="eu" hreflang="eu" data-title="Diazoxido" data-language-autonym="Euskara" data-language-local-name="basco" class="interlanguage-link-target"><span>Euskara</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%AF%DB%8C%D8%A7%D8%B2%D9%88%DA%A9%D8%B3%D8%A7%DB%8C%D8%AF" title="دیازوکساید - persiano" lang="fa" hreflang="fa" data-title="دیازوکساید" data-language-autonym="فارسی" data-language-local-name="persiano" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Diatsoksidi" title="Diatsoksidi - finlandese" lang="fi" hreflang="fi" data-title="Diatsoksidi" data-language-autonym="Suomi" data-language-local-name="finlandese" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Diazoxide" title="Diazoxide - francese" lang="fr" hreflang="fr" data-title="Diazoxide" data-language-autonym="Français" data-language-local-name="francese" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-hr mw-list-item"><a href="https://hr.wikipedia.org/wiki/Diazoksid" title="Diazoksid - croato" lang="hr" hreflang="hr" data-title="Diazoksid" data-language-autonym="Hrvatski" data-language-local-name="croato" class="interlanguage-link-target"><span>Hrvatski</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EB%94%94%EC%95%84%EC%A1%B1%EC%82%AC%EC%9D%B4%EB%93%9C" title="디아족사이드 - coreano" lang="ko" hreflang="ko" data-title="디아족사이드" data-language-autonym="한국어" data-language-local-name="coreano" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-or mw-list-item"><a href="https://or.wikipedia.org/wiki/%E0%AC%A1%E0%AC%BE%E0%AC%8F%E0%AC%9C%E0%AD%8B%E0%AC%95%E0%AD%8D%E0%AC%B8%E0%AC%BE%E0%AC%87%E0%AC%A1" title="ଡାଏଜୋକ୍ସାଇଡ - odia" lang="or" hreflang="or" data-title="ଡାଏଜୋକ୍ସାଇଡ" data-language-autonym="ଓଡ଼ିଆ" data-language-local-name="odia" class="interlanguage-link-target"><span>ଓଡ଼ିଆ</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Diazoksyd" title="Diazoksyd - polacco" lang="pl" hreflang="pl" data-title="Diazoksyd" data-language-autonym="Polski" data-language-local-name="polacco" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Diazoxid" title="Diazoxid - rumeno" lang="ro" hreflang="ro" data-title="Diazoxid" data-language-autonym="Română" data-language-local-name="rumeno" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%94%D0%B8%D0%B0%D0%B7%D0%BE%D0%BA%D1%81%D0%B8%D0%B4" title="Диазоксид - russo" lang="ru" hreflang="ru" data-title="Диазоксид" data-language-autonym="Русский" data-language-local-name="russo" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Diazoksid" title="Diazoksid - serbo-croato" lang="sh" hreflang="sh" data-title="Diazoksid" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="serbo-croato" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Diazoksid" title="Diazoksid - serbo" lang="sr" hreflang="sr" data-title="Diazoksid" data-language-autonym="Српски / srpski" data-language-local-name="serbo" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%94%D1%96%D0%B0%D0%B7%D0%BE%D0%BA%D1%81%D0%B8%D0%B4" title="Діазоксид - ucraino" lang="uk" hreflang="uk" data-title="Діазоксид" data-language-autonym="Українська" data-language-local-name="ucraino" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E4%BA%8C%E6%B0%AE%E5%97%AA" title="二氮嗪 - cinese" lang="zh" hreflang="zh" data-title="二氮嗪" data-language-autonym="中文" data-language-local-name="cinese" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q420009#sitelinks-wikipedia" title="Modifica collegamenti interlinguistici" class="wbc-editpage">Modifica collegamenti</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Namespace"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Diazossido" title="Vedi la voce [c]" accesskey="c"><span>Voce</span></a></li><li id="ca-talk" class="vector-tab-noicon mw-list-item"><a href="/wiki/Discussione:Diazossido" rel="discussion" title="Vedi le discussioni relative a questa pagina [t]" accesskey="t"><span>Discussione</span></a></li> </ul> </div> </div> <div id="vector-variants-dropdown" class="vector-dropdown emptyPortlet" > <input type="checkbox" id="vector-variants-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-variants-dropdown" class="vector-dropdown-checkbox " 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href="/w/index.php?title=Diazossido&veaction=edit" title="Modifica questa pagina [v]" accesskey="v"><span>Modifica</span></a></li><li id="ca-edit" class="collapsible vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Diazossido&action=edit" title="Modifica il wikitesto di questa pagina [e]" accesskey="e"><span>Modifica wikitesto</span></a></li><li id="ca-history" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Diazossido&action=history" title="Versioni precedenti di questa pagina [h]" accesskey="h"><span>Cronologia</span></a></li> </ul> </div> </div> </nav> <nav class="vector-page-tools-landmark" aria-label="Strumenti pagine"> <div id="vector-page-tools-dropdown" class="vector-dropdown vector-page-tools-dropdown" > <input type="checkbox" id="vector-page-tools-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-tools-dropdown" class="vector-dropdown-checkbox " aria-label="Strumenti" > <label 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I contenuti hanno solo fine illustrativo e non sostituiscono il parere medico: <a href="/wiki/Wikipedia:Disclaimer_medico" title="Wikipedia:Disclaimer medico">leggi le avvertenze</a>.</span></div> </div> <table class="infobox sinottico" summary="Tabella sinottica che riassume i principali dati del soggetto" style="width:300px;"><tbody><tr class="sinottico_testata"><th colspan="2" style="background-color:#AADDFF;">Diazossido</th></tr><tr><td class="sinottico_testo_centrale" colspan="2"><figure class="mw-halign-center" typeof="mw:File/Frameless"><a href="/wiki/File:Diazoxide_Structural_Formula_V.1.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/c/c1/Diazoxide_Structural_Formula_V.1.svg/200px-Diazoxide_Structural_Formula_V.1.svg.png" decoding="async" width="200" height="121" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/c1/Diazoxide_Structural_Formula_V.1.svg/300px-Diazoxide_Structural_Formula_V.1.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/c1/Diazoxide_Structural_Formula_V.1.svg/400px-Diazoxide_Structural_Formula_V.1.svg.png 2x" data-file-width="410" data-file-height="249" /></a><figcaption></figcaption></figure> </td></tr><tr class="sinottico_divisione"><th colspan="2" style="background-color:#AAEEFF;">Caratteristiche generali</th></tr><tr><th><a href="/wiki/Formula_bruta" title="Formula bruta">Formula bruta</a> o <a href="/wiki/Formula_molecolare" title="Formula molecolare">molecolare</a></th><td>C<sub>8</sub>H<sub>7</sub>ClN<sub>2</sub>O<sub>2</sub>S </td></tr><tr><th><a href="/wiki/Numero_CAS" title="Numero CAS">Numero CAS</a></th><td><span class="reflink plainlinksneverexpand"><span class="noarchive"><a class="external text" href="https://iw.toolforge.org/magnustools/cas.php?language=it&cas=364-98-7">364-98-7</a></span></span> </td></tr><tr><th><a href="/wiki/Numero_EINECS" title="Numero EINECS">Numero EINECS</a></th><td>206-668-1 </td></tr><tr><th><a href="/wiki/Sistema_di_classificazione_anatomico,_terapeutico_e_chimico" title="Sistema di classificazione anatomico, terapeutico e chimico">Codice ATC</a></th><td><a href="/wiki/Codice_ATC_C02" title="Codice ATC C02">C02</a><span class="reflink plainlinksneverexpand"><a rel="nofollow" class="external text" href="http://www.whocc.no/atc_ddd_index/?code=C02DA01">DA01</a></span> </td></tr><tr><th><a href="/wiki/PubChem" title="PubChem">PubChem</a></th><td><a rel="nofollow" class="external text" href="http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3019">3019</a> </td></tr><tr><th><a href="/wiki/DrugBank" title="DrugBank">DrugBank</a></th><td><a rel="nofollow" class="external text" href="http://www.drugbank.ca/drugs/DBDB01119">DBDB01119</a> </td></tr><tr><th><a href="/wiki/SMILES" title="SMILES">SMILES</a></th><td><div style="word-break: break-all;"><code style="background-color:transparent; border:none">CC1=NS(=O)(=O)C2=C(N1)C=CC(=C2)Cl</code></div> </td></tr><tr class="sinottico_divisione"><th colspan="2" style="background-color:#AAEEFF;">Dati farmacologici</th></tr><tr><th>Modalità di<br /><a href="/wiki/Somministrazione_(farmacologia)" title="Somministrazione (farmacologia)">somministrazione</a></th><td>Orale - Intravenosa </td></tr><tr class="sinottico_divisione"><th colspan="2" style="background-color:#AAEEFF;">Dati farmacocinetici</th></tr><tr><th><a href="/wiki/Emivita_(farmacologia)" title="Emivita (farmacologia)">Emivita</a></th><td>21-45 ore </td></tr><tr class="sinottico_divisione"><th colspan="2" style="background-color:#AAEEFF;">Indicazioni di sicurezza</th></tr><tr class="sinottico_divisione"><th colspan="2" style="background-color:#DDEEFF; font-weight:normal;"><a href="/wiki/Simboli_di_rischio_chimico" title="Simboli di rischio chimico">Simboli di rischio chimico</a></th></tr><tr><td class="sinottico_testo_centrale" colspan="2"><span typeof="mw:File"><a href="/wiki/File:GHS-pictogram-exclam.svg" class="mw-file-description" title="irritante"><img alt="irritante" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/c3/GHS-pictogram-exclam.svg/50px-GHS-pictogram-exclam.svg.png" decoding="async" width="50" height="50" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/c3/GHS-pictogram-exclam.svg/75px-GHS-pictogram-exclam.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/c3/GHS-pictogram-exclam.svg/100px-GHS-pictogram-exclam.svg.png 2x" data-file-width="512" data-file-height="512" /></a></span>  </td></tr><tr><td class="sinottico_testo_centrale" colspan="2">attenzione </td></tr><tr><th><a href="/wiki/Frasi_H" class="mw-redirect" title="Frasi H">Frasi H</a></th><td><abbr title="Nocivo se ingerito.">302 </abbr>- <abbr title="Provoca irritazione cutanea.">315 </abbr>- <abbr title="Provoca grave irritazione oculare.">319 </abbr>- <abbr title="Può irritare le vie respiratorie.">335 </abbr> </td></tr><tr><th><a href="/wiki/Consigli_P" title="Consigli P">Consigli P</a></th><td><abbr title="Evitare di respirare la polvere / i fumi / i gas / la nebbia / i vapori / gli aerosol.">261 </abbr>- <abbr title="In caso di contatto con gli occhi: sciacquare accuratamente per parecchi minuti. Togliere le eventuali lenti a contatto se è agevole farlo. Continuare a sciacquare.">305+351+338 </abbr><sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </td></tr><tr><td class="sinottico_piede2 noprint nomobile metadata" colspan="2"><a href="https://www.wikidata.org/wiki/Q420009" class="extiw" title="d:Q420009"><span title="Modifica i dati della voce Diazossido su Wikidata">Modifica dati su Wikidata</span></a><b> ·</b> <a href="/wiki/Template:Composto_chimico/man" title="Template:Composto chimico/man"><span title="Manuale del template Composto chimico">Manuale</span></a></td></tr></tbody></table> <p>Il <b>diazossido</b> è una molecola strutturalmente correlata ai <a href="/wiki/Diuretici_tiazidici" title="Diuretici tiazidici">diuretici tiazidici</a>, ma che si caratterizza per la capacità di attivare i canali del <a href="/wiki/Potassio" title="Potassio">potassio</a>, aumentando la permeabilità della <a href="/wiki/Membrana_cellulare" title="Membrana cellulare">membrana</a> agli stessi ioni potassio e provocando il rilassamento della <a href="/wiki/Muscolatura_liscia" class="mw-redirect" title="Muscolatura liscia">muscolatura liscia</a>.<sup id="cite_ref-pmid1422577_2-0" class="reference"><a href="#cite_note-pmid1422577-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> Come <a href="/wiki/Farmaco" title="Farmaco">farmaco</a> viene utilizzato sia in caso di emergenze ipertensive che in caso di <a href="/wiki/Ipoglicemia" title="Ipoglicemia">ipoglicemia</a>. In Italia viene venduto dalla società <a href="/wiki/Merck" class="mw-disambig" title="Merck">Merck</a> con il nome commerciale di "Proglicem" nella forma farmaceutica di capsule rigide contenenti 25 o 100 mg di <a href="/wiki/Principio_attivo" title="Principio attivo">principio attivo</a>. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Caratteristiche_strutturali_e_fisiche">Caratteristiche strutturali e fisiche</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Diazossido&veaction=edit&section=1" title="Modifica la sezione Caratteristiche strutturali e fisiche" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Diazossido&action=edit&section=1" title="Edit section's source code: Caratteristiche strutturali e fisiche"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Il composto si presenta come una polvere cristallina bianca o biancastra. Risulta pressoché insolubile in acqua e nella maggior parte dei <a href="/wiki/Solventi_organici" class="mw-redirect" title="Solventi organici">solventi organici</a>. È invece facilmente solubile in <a href="/wiki/Dimetilformammide" title="Dimetilformammide">dimetilformammide</a> ed in soluzioni fortemente <a href="/wiki/Alcalinit%C3%A0" title="Alcalinità">alcaline</a>. </p> <div class="mw-heading mw-heading2"><h2 id="Farmacodinamica">Farmacodinamica</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Diazossido&veaction=edit&section=2" title="Modifica la sezione Farmacodinamica" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Diazossido&action=edit&section=2" title="Edit section's source code: Farmacodinamica"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Diazossido, in particolare quando viene somministrato per via endovenosa, produce una riduzione della <a href="/wiki/Pressione_arteriosa" class="mw-redirect" title="Pressione arteriosa">pressione arteriosa</a>, secondaria ad un effetto <a href="/wiki/Vasodilatatore" title="Vasodilatatore">vasodilatatore</a> sulle <a href="/wiki/Arteriole" class="mw-redirect" title="Arteriole">arteriole</a>, che comporta una diminuzione delle resistenze periferiche. Per via orale la molecola aumenta la concentrazione di <a href="/wiki/Glucosio" title="Glucosio">glucosio</a> nel <a href="/wiki/Plasma_(biologia)" title="Plasma (biologia)">plasma</a> inibendo la secrezione di <a href="/wiki/Insulina" title="Insulina">insulina</a> dalle <a href="/wiki/Cellule_%CE%B2" title="Cellule β">cellule β</a> pancreatiche, oltre che attraverso alcuni meccanismi extrapancreatici non completamente chiariti.<sup id="cite_ref-pmid8203255_3-0" class="reference"><a href="#cite_note-pmid8203255-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> Il composto inibisce anche l'escrezione renale dell'<a href="/wiki/Acido_urico" title="Acido urico">acido urico</a> e tende ad aumentare i livelli sierici degli <a href="/wiki/Acidi_grassi" title="Acidi grassi">acidi grassi</a> liberi. </p> <div class="mw-heading mw-heading2"><h2 id="Farmacocinetica">Farmacocinetica</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Diazossido&veaction=edit&section=3" title="Modifica la sezione Farmacocinetica" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Diazossido&action=edit&section=3" title="Edit section's source code: Farmacocinetica"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>A seguito di somministrazione <a href="/wiki/Per_via_orale" class="mw-redirect" title="Per via orale">per via orale</a> il diazossido è assorbito in modo rapido dal <a href="/wiki/Tratto_gastroenterico" class="mw-redirect" title="Tratto gastroenterico">tratto gastroenterico</a>. Nel giro di un'ora è possibile evidenziare l'effetto iperglicemizzante che, in genere, non perdura oltre le 8 ore. L'<a href="/wiki/Emivita_(farmacologia)" title="Emivita (farmacologia)">emivita</a> plasmatica è variabile tra le 24 e le 36 ore. Il legame della molecola con le <a href="/wiki/Proteine_plasmatiche" title="Proteine plasmatiche">proteine plasmatiche</a> è per oltre il 90%, ma si riduce in soggetti con insufficienza renale.<sup id="cite_ref-pmid328207_4-0" class="reference"><a href="#cite_note-pmid328207-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> Il farmaco viene eliminato dall'organismo attraverso l'<a href="/wiki/Urine" class="mw-redirect" title="Urine">emuntorio renale</a>. </p> <div class="mw-heading mw-heading2"><h2 id="Tossicologia">Tossicologia</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Diazossido&veaction=edit&section=4" title="Modifica la sezione Tossicologia" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Diazossido&action=edit&section=4" title="Edit section's source code: Tossicologia"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Studi sperimentali sugli animali hanno messo in evidenza un valore di <a href="/wiki/DL50" title="DL50">DL50</a>, a seguito di somministrazione per via orale, pari a 210 mg/kg peso corporeo nella <a href="/wiki/Cavia" title="Cavia">cavia</a>, fra 1900 e 2572 mg/kg nel <a href="/wiki/Mus_musculus" title="Mus musculus">topo</a>, superiore a 500 mg/kg nel <a href="/wiki/Cane" class="mw-redirect" title="Cane">cane</a> e superiore a 5000 mg/kg nel <a href="/wiki/Ratto" class="mw-redirect" title="Ratto">ratto</a>. </p> <div class="mw-heading mw-heading2"><h2 id="Usi_clinici">Usi clinici</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Diazossido&veaction=edit&section=5" title="Modifica la sezione Usi clinici" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Diazossido&action=edit&section=5" title="Edit section's source code: Usi clinici"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Diazossido viene usato per via orale nella gestione dell'<a href="/wiki/Ipoglicemia" title="Ipoglicemia">ipoglicemia</a> intrattabile (ad esempio secondaria ad <a href="/wiki/Insulinoma" title="Insulinoma">insulinoma</a> oppure a iperinsulinismo congenito)<sup id="cite_ref-pmid17053028_5-0" class="reference"><a href="#cite_note-pmid17053028-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> mentre la via endovenosa viene utilizzata per trattare le crisi ipertensive, specialmente in quei pazienti in cui altri farmaci, ad esempio il nitroprussiato di sodio, si sono dimostrati di scarsa utilità. Il farmaco, a causa dei suoi effetti collaterali, non è adatto nei soggetti <a href="/wiki/Ipertensione" class="mw-redirect" title="Ipertensione">ipertesi</a> per un utilizzo prolungato nel tempo. Dosi pari o superiori a 300 mg possono portare ad <a href="/wiki/Angina_pectoris" title="Angina pectoris">angina pectoris</a> e <a href="/wiki/Infarto_miocardico_acuto" title="Infarto miocardico acuto">infarto miocardico acuto</a>, o <a href="/wiki/Infarto_cerebrale" class="mw-redirect" title="Infarto cerebrale">infarto cerebrale</a>. </p> <div class="mw-heading mw-heading2"><h2 id="Effetti_collaterali_e_indesiderati">Effetti collaterali e indesiderati</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Diazossido&veaction=edit&section=6" title="Modifica la sezione Effetti collaterali e indesiderati" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Diazossido&action=edit&section=6" title="Edit section's source code: Effetti collaterali e indesiderati"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Oltre alla marcata <a href="/wiki/Ipotensione" title="Ipotensione">ipotensione</a> e <a href="/wiki/Iperglicemia" title="Iperglicemia">iperglicemia</a>, possono verificarsi diversi altri effetti avversi. In particolare si può determinare ritenzione di sodio e di liquidi: questo effetto tende a risponde prontamente al trattamento diuretico, ma potrebbe precipitare un'insufficienza cardiaca congestizia in soggetti predisposti. Anche uno stato di chetoacidosi diabetica e coma non chetonico iperosmolare possono associarsi, sia pure raramente, al trattamento con diazossido.<br /> Altri effetti avversi includono <a href="/wiki/Dispepsia" title="Dispepsia">dispepsia</a>, riduzione dell'appetito, <a href="/wiki/Nausea" title="Nausea">nausea</a>, <a href="/wiki/Dolore_addominale" title="Dolore addominale">dolore addominale</a>. Relativamente comuni anche <a href="/wiki/Iperuricemia" title="Iperuricemia">iperuricemia</a> e <a href="/wiki/Gotta" title="Gotta">gotta</a>. Tra i disturbi neurologici si segnalano <a href="/wiki/Ansia" title="Ansia">ansia</a>, <a href="/wiki/Vertigine_(medicina)" class="mw-redirect" title="Vertigine (medicina)">vertigini</a>, <a href="/wiki/Cefalea" title="Cefalea">cefalea</a>, <a href="/wiki/Insonnia" title="Insonnia">insonnia</a>, sintomi extrapiramidali,<sup id="cite_ref-pmid1114967_6-0" class="reference"><a href="#cite_note-pmid1114967-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid4726153_7-0" class="reference"><a href="#cite_note-pmid4726153-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Parestesie" class="mw-redirect" title="Parestesie">parestesie</a>.<br /> I disturbi ematologici includono eosinofilia, emolisi,<sup id="cite_ref-pmid1215255_8-0" class="reference"><a href="#cite_note-pmid1215255-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> anemia, <a href="/wiki/Leucopenia" title="Leucopenia">leucopenia</a>, trombocitopenia che può accompagnarsi a porpora e neutropenia (in genere transitoria).<sup id="cite_ref-pmid6028904_9-0" class="reference"><a href="#cite_note-pmid6028904-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid4163755_10-0" class="reference"><a href="#cite_note-pmid4163755-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> In alcuni soggetti possono verificarsi <a href="/wiki/Cardiopalmo" title="Cardiopalmo">cardiopalmo</a>, <a href="/wiki/Tachicardia" title="Tachicardia">tachicardia</a> e molto raramente <a href="/wiki/Dolore_toracico" title="Dolore toracico">dolore toracico</a>.<br /> Frequentemente può invece comparire <a href="/wiki/Ipertricosi" title="Ipertricosi">ipertricosi</a>: questo fastidioso effetto avverso è più frequente nel sesso femminile e nei soggetti in età pediatrica.<sup id="cite_ref-pmid1220817_11-0" class="reference"><a href="#cite_note-pmid1220817-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid2085505_12-0" class="reference"><a href="#cite_note-pmid2085505-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> L'<a href="/wiki/Irsutismo" title="Irsutismo">irsutismo</a> tende a manifestarsi sotto forma di una peluria lanuginosa in alcune particolari zone corporee: la parte superiore del viso, la schiena e gli arti.<sup id="cite_ref-pmid5243880_13-0" class="reference"><a href="#cite_note-pmid5243880-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid22989667_14-0" class="reference"><a href="#cite_note-pmid22989667-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Dosi_terapeutiche">Dosi terapeutiche</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Diazossido&veaction=edit&section=7" title="Modifica la sezione Dosi terapeutiche" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Diazossido&action=edit&section=7" title="Edit section's source code: Dosi terapeutiche"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li>Ipoglicemia</li></ul> <p>La dose iniziale varia da 3 a 5 mg/kg peso corporeo al giorno, per via orale e suddivisi in 2-3 dosi. Il dosaggio successivo viene variato a seconda della risposta terapeutica. </p> <ul><li>Ipertensione arteriosa</li></ul> <p>Nei soggetti che manifestano una crisi ipertensiva è indicato un bolo endovenoso rapido (in 30 secondi) di una dose variabile tra 1 e 3 mg/kg peso corporeo, non superando il dosaggio massimo di 150 mg. Tale bolo può essere ripetuto a distanza di 5 o 15 minuti, qualora necessario. Dosaggi proporzionalmente inferiori devono essere utilizzati nei soggetti con deterioramento della funzionalità renale. </p> <div class="mw-heading mw-heading2"><h2 id="Interazioni">Interazioni</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Diazossido&veaction=edit&section=8" title="Modifica la sezione Interazioni" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Diazossido&action=edit&section=8" title="Edit section's source code: Interazioni"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Idroclorotiazide" title="Idroclorotiazide">Idroclorotiazide</a>: la contemporanea somministrazione con diazossido può comportare iperglicemia.<sup id="cite_ref-pmid4299222_15-0" class="reference"><a href="#cite_note-pmid4299222-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup></li></ul> <div class="mw-heading mw-heading2"><h2 id="Note">Note</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Diazossido&veaction=edit&section=9" title="Modifica la sezione Note" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Diazossido&action=edit&section=9" title="Edit section's source code: Note"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-1"><a href="#cite_ref-1"><b>^</b></a> <span class="reference-text">Sigma Aldrich; rev. del 08.10.2012</span> </li> <li id="cite_note-pmid1422577-2"><a href="#cite_ref-pmid1422577_2-0"><b>^</b></a> <span class="reference-text"><cite class="citation pubblicazione" style="font-style:normal"> RZ. Kozlowski, ML. Ashford, <a rel="nofollow" class="external text" href="https://archive.org/details/sim_british-journal-of-pharmacology_1992-09_107_1/page/34"><span style="font-style:italic;">Nucleotide-dependent activation of KATP channels by diazoxide in CRI-G1 insulin-secreting cells.</span></a>, in <span style="font-style:italic;">Br J Pharmacol</span>, vol. 107, n. 1, Set 1992, pp. 34-43, <a href="/wiki/PMID" title="PMID">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/1422577">1422577</a>.</cite></span> </li> <li id="cite_note-pmid8203255-3"><a href="#cite_ref-pmid8203255_3-0"><b>^</b></a> <span class="reference-text"><cite class="citation pubblicazione" style="font-style:normal"> Y. Goto, K. Kida; Y. Kaino; T. Ito; H. Matsuda, <span style="font-style:italic;">An extrapancreatic action of diazoxide to inhibit glucose transport activity on adipocytes.</span>, in <span style="font-style:italic;">Acta Paediatr Jpn</span>, vol. 36, n. 2, Apr 1994, pp. 128-32, <a href="/wiki/PMID" title="PMID">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/8203255">8203255</a>.</cite></span> </li> <li id="cite_note-pmid328207-4"><a href="#cite_ref-pmid328207_4-0"><b>^</b></a> <span class="reference-text"><cite class="citation pubblicazione" style="font-style:normal"> RM. Pearson, <span style="font-style:italic;">Pharmacokinetics and response to diazoxide in renal failure.</span>, in <span style="font-style:italic;">Clin Pharmacokinet</span>, vol. 2, n. 3, pp. 198-204, <a href="/wiki/PMID" title="PMID">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/328207">328207</a>.</cite></span> </li> <li id="cite_note-pmid17053028-5"><a href="#cite_ref-pmid17053028_5-0"><b>^</b></a> <span class="reference-text"><cite class="citation pubblicazione" style="font-style:normal"> Q. Huang, S. Bu; Y. Yu; Z. Guo; G. Ghatnekar; M. Bu; L. Yang; B. Lu; Z. Feng; S. Liu; F. Wang, <a rel="nofollow" class="external text" href="https://oadoi.org/10.1210/en.2006-0738"><span style="font-style:italic;">Diazoxide prevents diabetes through inhibiting pancreatic beta-cells from apoptosis via Bcl-2/Bax rate and p38-beta mitogen-activated protein kinase.</span></a>, in <span style="font-style:italic;">Endocrinology</span>, vol. 148, n. 1, Gen 2007, pp. 81-91, <a href="/wiki/Digital_object_identifier" title="Digital object identifier">DOI</a>:<a rel="nofollow" class="external text" href="https://dx.doi.org/10.1210%2Fen.2006-0738">10.1210/en.2006-0738</a>, <a href="/wiki/PMID" title="PMID">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/17053028">17053028</a>.</cite></span> </li> <li id="cite_note-pmid1114967-6"><a href="#cite_ref-pmid1114967_6-0"><b>^</b></a> <span class="reference-text"><cite class="citation pubblicazione" style="font-style:normal"> JE. Pohl, <a rel="nofollow" class="external text" href="https://archive.org/details/sim_american-heart-journal_1975-03_89_3/page/401"><span style="font-style:italic;">Development and management of extrapyramidal symptoms in hypertensive patients treated with diazoxide.</span></a>, in <span style="font-style:italic;">Am Heart J</span>, vol. 89, n. 3, Mar 1975, pp. 401-2, <a href="/wiki/PMID" title="PMID">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/1114967">1114967</a>.</cite></span> </li> <li id="cite_note-pmid4726153-7"><a href="#cite_ref-pmid4726153_7-0"><b>^</b></a> <span class="reference-text"><cite class="citation pubblicazione" style="font-style:normal"> D. Neary, H. Thurston; JE. Pohl, <span style="font-style:italic;">Development of extrapyramidal symptoms in hypertensive patients treated with diazoxide.</span>, in <span style="font-style:italic;">Br Med J</span>, vol. 3, n. 5878, Set 1973, pp. 474-5, <a href="/wiki/PMID" title="PMID">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/4726153">4726153</a>.</cite></span> </li> <li id="cite_note-pmid1215255-8"><a href="#cite_ref-pmid1215255_8-0"><b>^</b></a> <span class="reference-text"><cite class="citation pubblicazione" style="font-style:normal"> RA. Best, HM. Clink, <span style="font-style:italic;">Haemolysis associated with diazoxide, used for the control of hypertension.</span>, in <span style="font-style:italic;">Postgrad Med J</span>, vol. 51, n. 596, Giu 1975, pp. 402-4, <a href="/wiki/PMID" title="PMID">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/1215255">1215255</a>.</cite></span> </li> <li id="cite_note-pmid6028904-9"><a href="#cite_ref-pmid6028904_9-0"><b>^</b></a> <span class="reference-text"><cite class="citation pubblicazione" style="font-style:normal"> JT. Combs, JA. Grunt; IK. Brandt, <a rel="nofollow" class="external text" href="https://archive.org/details/sim_pediatrics_1967-07_40_1/page/90"><span style="font-style:italic;">Hematologic reactions to diazoxide.</span></a>, in <span style="font-style:italic;">Pediatrics</span>, vol. 40, n. 1, Lug 1967, pp. 90-2, <a href="/wiki/PMID" title="PMID">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/6028904">6028904</a>.</cite></span> </li> <li id="cite_note-pmid4163755-10"><a href="#cite_ref-pmid4163755_10-0"><b>^</b></a> <span class="reference-text"><cite class="citation pubblicazione" style="font-style:normal"> J. Wales, F. Wolff, <span style="font-style:italic;">Hematological side-effects of diazoxide.</span>, in <span style="font-style:italic;">Lancet</span>, vol. 1, n. 7480, Genn 1967, pp. 53-4, <a href="/wiki/PMID" title="PMID">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/4163755">4163755</a>.</cite></span> </li> <li id="cite_note-pmid1220817-11"><a href="#cite_ref-pmid1220817_11-0"><b>^</b></a> <span class="reference-text"><cite class="citation pubblicazione" style="font-style:normal"> JL. Burton, WH. Schutt; IW. Caldwell, <span style="font-style:italic;">Hypertrichosis due to diazoxide.</span>, in <span style="font-style:italic;">Br J Dermatol</span>, vol. 93, n. 6, Dic 1975, pp. 707-11, <a href="/wiki/PMID" title="PMID">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/1220817">1220817</a>.</cite></span> </li> <li id="cite_note-pmid2085505-12"><a href="#cite_ref-pmid2085505_12-0"><b>^</b></a> <span class="reference-text"><cite class="citation pubblicazione" style="font-style:normal"> H. Uno, JW. Kemnitz; A. Cappas; K. Adachi; A. Sakuma; H. Kamoda, <a rel="nofollow" class="external text" href="https://archive.org/details/sim_journal-of-dermatological-science_1990-05_1_3/page/183"><span style="font-style:italic;">The effects of topical diazoxide on hair follicular growth and physiology of the stumptailed macaque.</span></a>, in <span style="font-style:italic;">J Dermatol Sci</span>, vol. 1, n. 3, Mag 1990, pp. 183-94, <a href="/wiki/PMID" title="PMID">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/2085505">2085505</a>.</cite></span> </li> <li id="cite_note-pmid5243880-13"><a href="#cite_ref-pmid5243880_13-0"><b>^</b></a> <span class="reference-text"><cite class="citation pubblicazione" style="font-style:normal"> PJ. Koblenzer, L. Baker, <span style="font-style:italic;">Hypertrichosis lanuginosa associated with diazoxide therapy in prepubertal children: a clinicopathologic study.</span>, in <span style="font-style:italic;">Ann N Y Acad Sci</span>, vol. 150, n. 2, Apr 1968, pp. 373-82, <a href="/wiki/PMID" title="PMID">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/5243880">5243880</a>.</cite></span> </li> <li id="cite_note-pmid22989667-14"><a href="#cite_ref-pmid22989667_14-0"><b>^</b></a> <span class="reference-text"><cite class="citation pubblicazione" style="font-style:normal"> R. Salido, FJ. Gómez-García; G. Garnacho-Saucedo; M. Galán-Gutiérrez, <a rel="nofollow" class="external text" href="https://oadoi.org/10.1016/j.ad.2012.03.012"><span style="font-style:italic;">Acquired generalized hypertrichosis due to diazoxide.</span></a>, in <span style="font-style:italic;">Actas Dermosifiliogr</span>, vol. 104, n. 2, Mar 2013, pp. 166-7, <a href="/wiki/Digital_object_identifier" title="Digital object identifier">DOI</a>:<a rel="nofollow" class="external text" href="https://dx.doi.org/10.1016%2Fj.ad.2012.03.012">10.1016/j.ad.2012.03.012</a>, <a href="/wiki/PMID" title="PMID">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/22989667">22989667</a>.</cite></span> </li> <li id="cite_note-pmid4299222-15"><a href="#cite_ref-pmid4299222_15-0"><b>^</b></a> <span class="reference-text"><cite class="citation pubblicazione" style="font-style:normal"> AL. Graber, D. Porte; RH. Williams, <span style="font-style:italic;">Clinical use of diazoxide and studies of the mechanism of its hyperglycemic effects in man.</span>, in <span style="font-style:italic;">Ann N Y Acad Sci</span>, vol. 150, n. 2, Apr 1968, pp. 303-8, <a href="/wiki/PMID" title="PMID">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/4299222">4299222</a>.</cite></span> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="Bibliografia">Bibliografia</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Diazossido&veaction=edit&section=10" title="Modifica la sezione Bibliografia" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Diazossido&action=edit&section=10" title="Edit section's source code: Bibliografia"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><cite class="citation libro" style="font-style:normal"> British national formulary, <span style="font-style:italic;">Guida all’uso dei farmaci 4 edizione</span>, Lavis, agenzia italiana del farmaco, 2007.</cite></li></ul> <div class="mw-heading mw-heading2"><h2 id="Altri_progetti">Altri progetti</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Diazossido&veaction=edit&section=11" title="Modifica la sezione Altri progetti" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Diazossido&action=edit&section=11" title="Edit section's source code: Altri progetti"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <div id="interProject" class="toccolours" style="display: none; clear: both; margin-top: 2em"><p id="sisterProjects" style="background-color: #efefef; color: black; font-weight: bold; margin: 0"><span>Altri progetti</span></p><ul title="Collegamenti verso gli altri progetti Wikimedia"> <li class="" title=""><span class="plainlinks" title="commons:Category:Diazoxide"><a class="external text" href="https://commons.wikimedia.org/wiki/Category:Diazoxide?uselang=it">Wikimedia Commons</a></span></li></ul></div> <ul><li><span typeof="mw:File"><a href="https://commons.wikimedia.org/wiki/?uselang=it" title="Collabora a Wikimedia Commons"><img alt="Collabora a Wikimedia Commons" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/18px-Commons-logo.svg.png" decoding="async" width="18" height="24" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/27px-Commons-logo.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/36px-Commons-logo.svg.png 2x" data-file-width="1024" data-file-height="1376" /></a></span> <span class="plainlinks"><a class="external text" href="https://commons.wikimedia.org/wiki/?uselang=it">Wikimedia Commons</a></span> contiene immagini o altri file su <b><span class="plainlinks"><a class="external text" href="https://commons.wikimedia.org/wiki/Category:Diazoxide?uselang=it">Diazossido</a></span></b></li></ul> <style data-mw-deduplicate="TemplateStyles:r141815314">.mw-parser-output .navbox{border:1px solid #aaa;clear:both;margin:auto;padding:2px;width:100%}.mw-parser-output .navbox th{padding-left:1em;padding-right:1em;text-align:center}.mw-parser-output .navbox>tbody>tr:first-child>th{background:#ccf;font-size:90%;width:100%;color:var(--color-base,black)}.mw-parser-output .navbox_navbar{float:left;margin:0;padding:0 10px 0 0;text-align:left;width:6em}.mw-parser-output .navbox_title{font-size:110%}.mw-parser-output .navbox_abovebelow{background:#ddf;font-size:90%;font-weight:normal}.mw-parser-output .navbox_group{background:#ddf;font-size:90%;padding:0 10px;white-space:nowrap}.mw-parser-output .navbox_list{font-size:90%;width:100%}.mw-parser-output .navbox_list a{white-space:nowrap}html:not(.vector-feature-night-mode-enabled) .mw-parser-output .navbox_odd{background:#fdfdfd;color:var(--color-base,black)}html:not(.vector-feature-night-mode-enabled) .mw-parser-output .navbox_even{background:#f7f7f7;color:var(--color-base,black)}.mw-parser-output .navbox a.mw-selflink{color:var(--color-base,black)}.mw-parser-output .navbox_center{text-align:center}.mw-parser-output .navbox .navbox_image{padding-left:7px;vertical-align:middle;width:0}.mw-parser-output .navbox+.navbox{margin-top:-1px}.mw-parser-output .navbox .mw-collapsible-toggle{font-weight:normal;text-align:right;width:7em}body.skin--responsive .mw-parser-output .navbox_image img{max-width:none!important}.mw-parser-output .subnavbox{margin:-3px;width:100%}.mw-parser-output .subnavbox_group{background:#e6e6ff;padding:0 10px}@media screen{html.skin-theme-clientpref-night .mw-parser-output .navbox>tbody>tr:first-child>th{background:var(--background-color-interactive)!important}html.skin-theme-clientpref-night .mw-parser-output .navbox th{color:var(--color-base)!important}html.skin-theme-clientpref-night .mw-parser-output .navbox_abovebelow,html.skin-theme-clientpref-night .mw-parser-output .navbox_group{background:var(--background-color-interactive-subtle)!important}html.skin-theme-clientpref-night .mw-parser-output .subnavbox_group{background:var(--background-color-neutral-subtle)!important}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .navbox>tbody>tr:first-child>th{background:var(--background-color-interactive)!important}html.skin-theme-clientpref-os .mw-parser-output .navbox th{color:var(--color-base)!important}html.skin-theme-clientpref-os .mw-parser-output .navbox_abovebelow,html.skin-theme-clientpref-os .mw-parser-output .navbox_group{background:var(--background-color-interactive-subtle)!important}html.skin-theme-clientpref-os .mw-parser-output .subnavbox_group{background:var(--background-color-neutral-subtle)!important}}</style><table class="navbox mw-collapsible mw-collapsed noprint metadata" id="navbox-Farmaci_anti-ipertensivi"><tbody><tr><th colspan="2" style="background-color: #AFC8F5;"><div class="navbox_navbar"><div class="noprint plainlinks" style="background-color:transparent; padding:0; font-size:xx-small; color:var(--color-base, #000000); white-space:nowrap;"><a href="/wiki/Template:Farmaci_anti-ipertensivi" title="Template:Farmaci anti-ipertensivi"><span title="Vai alla pagina del template">V</span></a> · <a href="/w/index.php?title=Discussioni_template:Farmaci_anti-ipertensivi&action=edit&redlink=1" class="new" title="Discussioni template:Farmaci anti-ipertensivi (la pagina non esiste)"><span title="Discuti del template">D</span></a> · <a class="external text" href="https://it.wikipedia.org/w/index.php?title=Template:Farmaci_anti-ipertensivi&action=edit"><span title="Modifica il template. Usa l'anteprima prima di salvare">M</span></a></div></div><span class="navbox_title"><a href="/wiki/Farmaci_anti-ipertensivi" class="mw-redirect" title="Farmaci anti-ipertensivi">Farmaci anti-ipertensivi</a></span></th></tr><tr><th colspan="1" class="navbox_group">Principali</th><td colspan="1" class="navbox_list navbox_odd"><table class="subnavbox"><tbody><tr><th class="subnavbox_group"><a href="/wiki/Diuretici" title="Diuretici">Diuretici</a></th><td colspan="1"><table class="subnavbox"><tbody><tr><th class="subnavbox_group">Inibitori dell'<a href="/wiki/Anidrasi_carbonica" class="mw-redirect" title="Anidrasi carbonica">anidrasi carbonica</a></th><td colspan="1"><a href="/wiki/Acetazolamide" title="Acetazolamide">Acetazolamide</a><b> ·</b> <a href="/wiki/Diclorfenamide" class="mw-redirect" title="Diclorfenamide">Diclorfenamide</a><b> ·</b> <a href="/wiki/Dorzolamide" title="Dorzolamide">Dorzolamide</a><b> ·</b> <a href="/wiki/Metazolamide" title="Metazolamide">Metazolamide</a></td></tr><tr><th class="subnavbox_group"><a href="/wiki/Diuretici_dell%27ansa" title="Diuretici dell'ansa">Diuretici dell'ansa</a></th><td colspan="1"><a href="/wiki/Acido_etacrinico" title="Acido etacrinico">Acido etacrinico</a><b> ·</b> <a href="/wiki/Bumetanide" title="Bumetanide">Bumetanide</a><b> ·</b> <a href="/wiki/Furosemide" title="Furosemide">Furosemide</a><b> ·</b> <a href="/wiki/Muzolimina" title="Muzolimina">Muzolimina</a><b> ·</b> <a href="/wiki/Piretanide" title="Piretanide">Piretanide</a><b> ·</b> <a href="/wiki/Torasemide" title="Torasemide">Torasemide</a></td></tr><tr><th class="subnavbox_group"><a href="/wiki/Diuretici_tiazidici" title="Diuretici tiazidici">Diuretici tiazidici</a></th><td colspan="1"><a href="/wiki/Bendroflumetiazide" title="Bendroflumetiazide">Bendroflumetiazide</a><b> ·</b> <a href="/w/index.php?title=Benzotiazide&action=edit&redlink=1" class="new" title="Benzotiazide (la pagina non esiste)">Benzotiazide</a><b> ·</b> <a href="/wiki/Ciclopentiazide" title="Ciclopentiazide">Ciclopentiazide</a><b> ·</b> <a href="/wiki/Clorotiazide" title="Clorotiazide">Clorotiazide</a><b> ·</b> <a href="/wiki/Idroclorotiazide" title="Idroclorotiazide">Idroclorotiazide</a><b> ·</b> <a href="/wiki/Idroflumetiazide" title="Idroflumetiazide">Idroflumetiazide</a><b> ·</b> <a href="/w/index.php?title=Metilclorotiazide&action=edit&redlink=1" class="new" title="Metilclorotiazide (la pagina non esiste)">Metilclorotiazide</a><b> ·</b> <a href="/w/index.php?title=Politiazide&action=edit&redlink=1" class="new" title="Politiazide (la pagina non esiste)">Politiazide</a><b> ·</b> <a href="/wiki/Triclormetiazide" title="Triclormetiazide">Triclormetiazide</a></td></tr><tr><th class="subnavbox_group"><a href="/wiki/Diuretici_risparmiatori_di_potassio" title="Diuretici risparmiatori di potassio">Diuretici risparmiatori di potassio</a></th><td colspan="1"><table class="subnavbox"><tbody><tr><th class="subnavbox_group">Antagonisti dell'<a href="/wiki/Aldosterone" title="Aldosterone">Aldosterone</a></th><td colspan="1"><a href="/wiki/Canrenoato_di_potassio" title="Canrenoato di potassio">Canrenoato di potassio</a><b> ·</b> <a href="/wiki/Eplerenone" title="Eplerenone">Eplerenone</a><b> ·</b> <a href="/wiki/Spironolattone" title="Spironolattone">Spironolattone</a></td></tr><tr><th class="subnavbox_group">Inibitori del canale per il sodio epiteliale renale</th><td colspan="1"><a href="/wiki/Amiloride" title="Amiloride">Amiloride</a><b> ·</b> <a href="/wiki/Triamterene" title="Triamterene">Triamterene</a></td></tr></tbody></table></td></tr><tr><th class="subnavbox_group">Diuretici osmotici</th><td colspan="1"><a href="/wiki/Mannitolo" title="Mannitolo">Mannitolo</a><b> ·</b> <a href="/wiki/Urea" title="Urea">Urea</a></td></tr><tr><th class="subnavbox_group">Antagonisti del recettore della vasopressina</th><td colspan="1"><i>Vaptani</i>: <a href="/w/index.php?title=Conivaptan&action=edit&redlink=1" class="new" title="Conivaptan (la pagina non esiste)">Conivaptan</a><b> ·</b> <a href="/w/index.php?title=Mozavaptan&action=edit&redlink=1" class="new" title="Mozavaptan (la pagina non esiste)">Mozavaptan</a><b> ·</b> <a href="/wiki/Satavaptan" title="Satavaptan">Satavaptan</a><b> ·</b> <a href="/wiki/Tolvaptan" title="Tolvaptan">Tolvaptan</a><br /> <i><a href="/wiki/Tetracicline" title="Tetracicline">Tetracicline</a></i>: <a href="/wiki/Demeclociclina" title="Demeclociclina">Demeclociclina</a></td></tr><tr><th class="subnavbox_group">Altri</th><td colspan="1"><a href="/wiki/Teobromina" title="Teobromina">Teobromina</a></td></tr></tbody></table></td></tr><tr><th class="subnavbox_group"><a href="/wiki/Betabloccanti" title="Betabloccanti">β-Bloccanti</a></th><td colspan="1"><table class="subnavbox"><tbody><tr><th class="subnavbox_group">Beta, non selettivi</th><td colspan="1"><a href="/wiki/Bopindololo" title="Bopindololo">Bopindololo</a><b> ·</b> <a href="/wiki/Butofilololo" title="Butofilololo">Butofilololo</a><b> ·</b> <a href="/wiki/Carteololo" title="Carteololo">Carteololo</a><b> ·</b> <a href="/wiki/Mepindololo" title="Mepindololo">Mepindololo</a><b> ·</b> <a href="/wiki/Nadololo" title="Nadololo">Nadololo</a><b> ·</b> <a href="/wiki/Oxprenololo" title="Oxprenololo">Oxprenololo</a><b> ·</b> <a href="/wiki/Pindololo" title="Pindololo">Pindololo</a><b> ·</b> <a href="/wiki/Practololo" title="Practololo">Practololo</a><b> ·</b> <a href="/wiki/Propranololo" title="Propranololo">Propranololo</a><b> ·</b> <a href="/wiki/Sotalolo" title="Sotalolo">Sotalolo</a><b> ·</b> <a href="/wiki/Timololo" title="Timololo">Timololo</a></td></tr><tr><th class="subnavbox_group">Selettivi β<sub>1</sub></th><td colspan="1"><a href="/wiki/Acebutololo" title="Acebutololo">Acebutololo</a><b> ·</b> <a href="/wiki/Atenololo" title="Atenololo">Atenololo</a><b> ·</b> <a href="/wiki/Betaxololo" title="Betaxololo">Betaxololo</a><b> ·</b> <a href="/wiki/Bevantololo" title="Bevantololo">Bevantololo</a><b> ·</b> <a href="/wiki/Bisoprololo" title="Bisoprololo">Bisoprololo</a><b> ·</b> <a href="/wiki/Celiprololo" title="Celiprololo">Celiprololo</a><b> ·</b> <a href="/w/index.php?title=Epanololo&action=edit&redlink=1" class="new" title="Epanololo (la pagina non esiste)">Epanololo</a><b> ·</b> <a href="/wiki/Esmololo" title="Esmololo">Esmololo</a><b> ·</b> <a href="/wiki/Nebivololo" title="Nebivololo">Nebivololo</a><b> ·</b> <a href="/wiki/Metoprololo" title="Metoprololo">Metoprololo</a><b> ·</b> <a href="/wiki/Practololo" title="Practololo">Practololo</a><b> ·</b> <a href="/w/index.php?title=Talinololo&action=edit&redlink=1" class="new" title="Talinololo (la pagina non esiste)">Talinololo</a></td></tr><tr><th class="subnavbox_group">Alfa + beta</th><td colspan="1"><a href="/wiki/Carvedilolo" title="Carvedilolo">Carvedilolo</a><b> ·</b> <a href="/wiki/Labetalolo" title="Labetalolo">Labetalolo</a></td></tr></tbody></table></td></tr><tr><th class="subnavbox_group"><a href="/wiki/Calcio-antagonisti" title="Calcio-antagonisti">Calcio-antagonisti</a></th><td colspan="1"><table class="subnavbox"><tbody><tr><th class="subnavbox_group"><a href="/wiki/Diidropiridina" title="Diidropiridina">Diidropiridine</a></th><td colspan="1"><a href="/wiki/Amlodipina" title="Amlodipina">Amlodipina</a><b> ·</b> <a href="/wiki/Barnidipina" title="Barnidipina">Barnidipina</a><b> ·</b> <a href="/wiki/Felodipina" title="Felodipina">Felodipina</a><b> ·</b> <a href="/wiki/Isradipina" title="Isradipina">Isradipina</a><b> ·</b> <a href="/wiki/Nicardipina" title="Nicardipina">Nicardipina</a><b> ·</b> <a href="/wiki/Nifedipina" title="Nifedipina">Nifedipina</a><b> ·</b> <a href="/wiki/Nisoldipina" title="Nisoldipina">Nisoldipina</a><b> ·</b> <a href="/wiki/Nitrendipina" title="Nitrendipina">Nitrendipina</a></td></tr><tr><th class="subnavbox_group">Fenilalchilammine</th><td colspan="1"><a href="/w/index.php?title=Anipamil&action=edit&redlink=1" class="new" title="Anipamil (la pagina non esiste)">Anipamil</a><b> ·</b> <a href="/wiki/Gallopamil" title="Gallopamil">Gallopamil</a><b> ·</b> <a href="/wiki/Verapamil" title="Verapamil">Verapamil</a></td></tr><tr><th class="subnavbox_group">Benzotiazepine</th><td colspan="1"><a href="/wiki/Diltiazem" title="Diltiazem">Diltiazem</a></td></tr></tbody></table></td></tr><tr><th class="subnavbox_group"><a href="/wiki/Inibitore_enzimatico" title="Inibitore enzimatico">Inibitori</a> <a href="/wiki/Sistema_renina-angiotensina-aldosterone" title="Sistema renina-angiotensina-aldosterone">sistema renina-angiotensina</a></th><td colspan="1"><table class="subnavbox"><tbody><tr><th class="subnavbox_group"><a href="/wiki/ACE-inibitore" title="ACE-inibitore">Ace-Inibitori</a></th><td colspan="1"><a href="/wiki/Benazepril" title="Benazepril">Benazepril</a><b> ·</b> <a href="/wiki/Captopril" title="Captopril">Captopril</a><b> ·</b> <a href="/wiki/Cilazapril" title="Cilazapril">Cilazapril</a><b> ·</b> <a href="/wiki/Enalapril" title="Enalapril">Enalapril</a><b> ·</b> <a href="/wiki/Fosinopril" title="Fosinopril">Fosinopril</a><b> ·</b> <a href="/wiki/Imidapril" title="Imidapril">Imidapril</a><b> ·</b> <a href="/wiki/Lisinopril" title="Lisinopril">Lisinopril</a><b> ·</b> <a href="/wiki/Moexipril" title="Moexipril">Moexipril</a><b> ·</b> <a href="/wiki/Perindopril" title="Perindopril">Perindopril</a><b> ·</b> <a href="/wiki/Quinapril" title="Quinapril">Quinapril</a><b> ·</b> <a href="/wiki/Ramipril" title="Ramipril">Ramipril</a><b> ·</b> <a href="/wiki/Spirapril" title="Spirapril">Spirapril</a><b> ·</b> <a href="/wiki/Trandolapril" title="Trandolapril">Trandolapril</a><b> ·</b> <a href="/wiki/Zofenopril" title="Zofenopril">Zofenopril</a></td></tr><tr><th class="subnavbox_group"><a href="/wiki/Antagonista_del_recettore_per_l%27angiotensina_II" title="Antagonista del recettore per l'angiotensina II">Antagonisti dei recettori<br /> per l'angiotensina II (Sartani)</a></th><td colspan="1"><a href="/wiki/Candesartan" title="Candesartan">Candesartan</a><b> ·</b> <a href="/wiki/Eprosartan" title="Eprosartan">Eprosartan</a><b> ·</b> <a href="/wiki/Irbesartan" title="Irbesartan">Irbesartan</a><b> ·</b> <a href="/wiki/Losartan" title="Losartan">Losartan</a><b> ·</b> <a href="/wiki/Olmesartan" title="Olmesartan">Olmesartan</a><b> ·</b> <a href="/wiki/Telmisartan" title="Telmisartan">Telmisartan</a><b> ·</b> <a href="/wiki/Valsartan" title="Valsartan">Valsartan</a></td></tr><tr><th class="subnavbox_group"><a href="/wiki/Inibitore_enzimatico" title="Inibitore enzimatico">Inibitori</a> diretti della <a href="/wiki/Renina" title="Renina">renina</a></th><td colspan="1"><a href="/wiki/Aliskiren" title="Aliskiren">Aliskiren</a></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><th colspan="1" class="navbox_group">Alternativi</th><td colspan="1" class="navbox_list navbox_even"><table class="subnavbox"><tbody><tr><th class="subnavbox_group"><a href="/wiki/Alfa_bloccante" class="mw-redirect" title="Alfa bloccante">α-Bloccanti</a></th><td colspan="1"><a href="/wiki/Alfuzosin" title="Alfuzosin">Alfuzosin</a><b> ·</b> <a href="/wiki/Doxazosina" title="Doxazosina">Doxazosina</a><b> ·</b> <a href="/wiki/Fenossibenzamina" title="Fenossibenzamina">Fenossibenzamina</a><b> ·</b> <a href="/wiki/Fentolamina" title="Fentolamina">Fentolamina</a><b> ·</b> <a href="/wiki/Prazosina" title="Prazosina">Prazosina</a><b> ·</b> <a href="/wiki/Tamsulosin" title="Tamsulosin">Tamsulosin</a><b> ·</b> <a href="/wiki/Terazosina" title="Terazosina">Terazosina</a></td></tr><tr><th class="subnavbox_group">Bloccanti i neuroni adrenergici</th><td colspan="1"><a href="/wiki/Guanetidina" title="Guanetidina">Guanetidina</a><b> ·</b> <a href="/wiki/Reserpina" title="Reserpina">Reserpina</a></td></tr><tr><th class="subnavbox_group">Simpaticolitici centrali</th><td colspan="1"><a href="/wiki/Clonidina" title="Clonidina">Clonidina</a><b> ·</b> <a href="/wiki/Debrisochina" title="Debrisochina">Debrisochina</a><b> ·</b> <a href="/wiki/Metildopa" title="Metildopa">Metildopa</a></td></tr><tr><th class="subnavbox_group"><a href="/wiki/Vasodilatatori" class="mw-redirect" title="Vasodilatatori">Vasodilatatori</a></th><td colspan="1"><a href="/wiki/Cadralazina" title="Cadralazina">Cadralazina</a><b> ·</b> <a href="/wiki/Cromakalim" title="Cromakalim">Cromakalim</a><b> ·</b> <a class="mw-selflink selflink">Diazossido</a><b> ·</b> <a href="/wiki/Fenoldopam" title="Fenoldopam">Fenoldopam</a><b> ·</b> <a href="/wiki/Idralazina" title="Idralazina">Idralazina</a><b> ·</b> <a href="/wiki/Minoxidil" title="Minoxidil">Minoxidil</a><b> ·</b> <a href="/wiki/Nitroprussiato_di_sodio" title="Nitroprussiato di sodio">Nitroprussiato di sodio</a></td></tr></tbody></table></td></tr><tr><td colspan="2" class="navbox_list navbox_center navbox_odd"><i>Vedi anche <a 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