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data-dom-id="Pill-react-component-61a45b6d-d152-4146-8e11-5b51ce65826b"></div> <div id="Pill-react-component-61a45b6d-d152-4146-8e11-5b51ce65826b"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="36080295" href="https://www.academia.edu/Documents/in/Cryopreservation"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Cryopreservation"]}" data-trace="false" data-dom-id="Pill-react-component-fdf1b869-1dc7-4677-ad32-b2159412eaeb"></div> <div id="Pill-react-component-fdf1b869-1dc7-4677-ad32-b2159412eaeb"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="36080295" href="https://www.academia.edu/Documents/in/Reconstruction_of_Cone-beam_Computed_Tomography"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Reconstruction of 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class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/16698280/Neurokinin_B_and_nitric_oxide_plasma_levels_in_pre_eclampsia_and_isolated_intrauterine_growth_restriction"><img alt="Research paper thumbnail of Neurokinin B and nitric oxide plasma levels in pre-eclampsia and isolated intrauterine growth restriction" class="work-thumbnail" src="https://attachments.academia-assets.com/42414150/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/16698280/Neurokinin_B_and_nitric_oxide_plasma_levels_in_pre_eclampsia_and_isolated_intrauterine_growth_restriction">Neurokinin B and nitric oxide plasma levels in pre-eclampsia and isolated intrauterine growth restriction</a></div><div class="wp-workCard_item"><span>Bjog-an International Journal of Obstetrics and Gynaecology</span><span>, 2004</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9939c9edf7930059391126e80122dc40" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42414150,"asset_id":16698280,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42414150/download_file?st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="16698280"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span 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Also, to ascertain if there is a correlation between neurokinin B plasma level and nitric oxide production. Design A total of 90 pregnant women were studied. Thirty had a gestation complicated by pre-eclampsia and 30 by isolated IUGR; the other 30 were controls. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13476935"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13476935/Is_apoptosis_cause_of_pre_eclampsia"><img alt="Research paper thumbnail of Is apoptosis cause of pre-eclampsia?" class="work-thumbnail" src="https://attachments.academia-assets.com/38057511/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13476935/Is_apoptosis_cause_of_pre_eclampsia">Is apoptosis cause of pre-eclampsia?</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MicheleBuemi">Michele Buemi</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/CarmelaAloisi">Carmela Aloisi</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/FCorica">Francesco Corica</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RosarioDAnna">Rosario D'Anna</a></span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Pre-eclampsia is the main cause of fetal and maternal morbidity and death associated with hyperte...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Pre-eclampsia is the main cause of fetal and maternal morbidity and death associated with hypertension during complicat- ing pregnancy. During physiological pregnancy, the immuno- logical system undergoes secondary modifica- tions, with an &quot;exchange&quot; between mother and fetus. Cytokines play an important role in the com- plex condition of partial fetal &quot;rejection&quot;. It has suggested that the condition depend on im-</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8397bf3298cf1bed33eb52d62264d2af" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":38057511,"asset_id":13476935,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/38057511/download_file?st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13476935"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13476935"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13476935; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13476935]").text(description); $(".js-view-count[data-work-id=13476935]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13476935; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13476935']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13476935, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8397bf3298cf1bed33eb52d62264d2af" } } $('.js-work-strip[data-work-id=13476935]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13476935,"title":"Is apoptosis cause of pre-eclampsia?","translated_title":"","metadata":{"abstract":"Pre-eclampsia is the main cause of fetal and maternal morbidity and death associated with hypertension during complicat- ing pregnancy. During physiological pregnancy, the immuno- logical system undergoes secondary modifica- tions, with an \u0026quot;exchange\u0026quot; between mother and fetus. Cytokines play an important role in the com- plex condition of partial fetal \u0026quot;rejection\u0026quot;. It has suggested that the condition depend on im-","publication_date":{"day":null,"month":null,"year":2000,"errors":{}}},"translated_abstract":"Pre-eclampsia is the main cause of fetal and maternal morbidity and death associated with hypertension during complicat- ing pregnancy. During physiological pregnancy, the immuno- logical system undergoes secondary modifica- tions, with an \u0026quot;exchange\u0026quot; between mother and fetus. Cytokines play an important role in the com- plex condition of partial fetal \u0026quot;rejection\u0026quot;. It has suggested that the condition depend on im-","internal_url":"https://www.academia.edu/13476935/Is_apoptosis_cause_of_pre_eclampsia","translated_internal_url":"","created_at":"2015-07-01T03:03:59.705-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32694920,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":1924843,"work_id":13476935,"tagging_user_id":32694920,"tagged_user_id":36080295,"co_author_invite_id":497662,"email":"b***m@unime.it","display_order":0,"name":"Michele Buemi","title":"Is apoptosis cause of pre-eclampsia?"},{"id":1924874,"work_id":13476935,"tagging_user_id":32694920,"tagged_user_id":62138897,"co_author_invite_id":523556,"email":"c***f@unime.it","display_order":4194304,"name":"Francesco Corica","title":"Is apoptosis cause of 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src="https://attachments.academia-assets.com/42414161/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/16698277/Impaired_antiviral_activity_of_monocytes_from_patients_on_hemodiafiltration">Impaired antiviral activity of monocytes from patients on hemodiafiltration</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c6cf66a70fa1cef7673a47bc9894ba03" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42414161,"asset_id":16698277,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42414161/download_file?st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa 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})(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c6cf66a70fa1cef7673a47bc9894ba03" } } $('.js-work-strip[data-work-id=16698277]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":16698277,"title":"Impaired antiviral activity of monocytes from patients on hemodiafiltration","translated_title":"","metadata":{"grobid_abstract":"The aim of our study was to determine whether intermittent hemodiafiltration (HDF) leads to an alteration in monocyte antiviral activity as well as in the in vitro release of cytokines such as interleukin-12 (IL-12), tumor necrosis factor-α (TNF-α) and interferon-α (IFN-α) by the same cells. Methods: We enrolled 25 patients undergoing HDF for 3.5-4 hours 3 times a week (12 men, 13 women; mean age 58 ± 6.7 years) and 25 healthy donors (ND) (12 men, 13 women; mean age 57 ± 8 years). Monocytes from peripheral blood mononuclear cells were isolated with a Monocyte Isolation Kit II. Monocytic cells were infected with herpes simplex virus type 2 (HSV-2). Cytokines were assayed in supernatants. Results: The in vitro antiviral activity of monocytes from HDF patients was significantly impaired with respect to ND. Furthermore, monocytes from post-HDF patients were more prone to viral infection.","publication_date":{"day":null,"month":null,"year":2007,"errors":{}},"grobid_abstract_attachment_id":42414161},"translated_abstract":null,"internal_url":"https://www.academia.edu/16698277/Impaired_antiviral_activity_of_monocytes_from_patients_on_hemodiafiltration","translated_internal_url":"","created_at":"2015-10-12T07:38:56.643-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36080295,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":42414161,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42414161/thumbnails/1.jpg","file_name":"Impaired_antiviral_activity_of_monocytes20160208-16427-1f0cs86.pdf","download_url":"https://www.academia.edu/attachments/42414161/download_file?st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Impaired_antiviral_activity_of_monocytes.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42414161/Impaired_antiviral_activity_of_monocytes20160208-16427-1f0cs86-libre.pdf?1454976472=\u0026response-content-disposition=attachment%3B+filename%3DImpaired_antiviral_activity_of_monocytes.pdf\u0026Expires=1732394066\u0026Signature=gG0m6YCydAlZRN8xY4sgvHYeIcXJpg3e~8d1eIDfpgpb74peI9e2DtTUoZ8oAgYj7mjTWqvRiyJ6t~hrYdvUPtpK2TxMqvOtkyDTeS-2AAsra~vD4myOOjCEHDrr3rZYr6YOuv1zN1l4DJrQTN56GsV3~gb16k2f3c2tKyKviNhGFPwj31qJsvY~oea-LI0EuzJc4MSNEElpfsGaqyX2Jz3U-P5rZfeRNasCotCmgglIRKRSTtEDnFydtrtGmSMi14vHd2xQTDFgzgnww0-ML8uIvOkoIaIFqZvw3KS4H6Q1QHSX8CH0a1r8-frbR2ulF8BIfEN4eZbjM9UdPEuEig__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Impaired_antiviral_activity_of_monocytes_from_patients_on_hemodiafiltration","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":36080295,"first_name":"Michele","middle_initials":null,"last_name":"Buemi","page_name":"MicheleBuemi","domain_name":"independent","created_at":"2015-10-12T07:37:32.970-07:00","display_name":"Michele 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diseases","url":"https://www.academia.edu/Documents/in/Kidney_diseases"},{"id":9111,"name":"Cytokines","url":"https://www.academia.edu/Documents/in/Cytokines"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":295155,"name":"Middle Aged","url":"https://www.academia.edu/Documents/in/Middle_Aged"},{"id":335983,"name":"Lipopolysaccharides","url":"https://www.academia.edu/Documents/in/Lipopolysaccharides"},{"id":402972,"name":"Monocytes","url":"https://www.academia.edu/Documents/in/Monocytes"},{"id":474029,"name":"Tumor necrosis factor-alpha","url":"https://www.academia.edu/Documents/in/Tumor_necrosis_factor-alpha"},{"id":902999,"name":"Antiviral 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class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/16698275/Interplay_of_Vitamin_D_Erythropoiesis_and_the_Renin_Angiotensin_System"><img alt="Research paper thumbnail of Interplay of Vitamin D, Erythropoiesis, and the Renin-Angiotensin System" class="work-thumbnail" src="https://attachments.academia-assets.com/39125785/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/16698275/Interplay_of_Vitamin_D_Erythropoiesis_and_the_Renin_Angiotensin_System">Interplay of Vitamin D, Erythropoiesis, and the Renin-Angiotensin System</a></div><div class="wp-workCard_item"><span>BioMed Research International</span><span>, 2015</span></div><div class="wp-workCard_item wp-workCard--actions"><span 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new Works.PaperRankView({ workId: 16698275, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "95f789ec8251c16e13c162ce47397d8b" } } $('.js-work-strip[data-work-id=16698275]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":16698275,"title":"Interplay of Vitamin D, Erythropoiesis, and the Renin-Angiotensin System","translated_title":"","metadata":{"grobid_abstract":"For many years deficiency of vitamin D was merely identified and assimilated to the presence of bone rickets. It is now clear that suboptimal vitamin D status may be correlated with several disorders and that the expression of 1--hydroxylase in tissues other than the kidney is widespread and of clinical relevance. Recently, evidence has been collected to suggest that, beyond the traditional involvement in mineral metabolism, vitamin D may interact with other kidney hormones such as renin and erythropoietin. This interaction would be responsible for some of the systemic and renal effects evoked for the therapy with vitamin D. The administration of analogues of vitamin D has been associated with an improvement of anaemia and reduction in ESA requirements. Moreover, vitamin D deficiency could contribute to an inappropriately activated or unsuppressed RAS, as a mechanism for progression of CKD and/or cardiovascular disease. Experimental data on the anti-RAS and anti-inflammatory effects treatment with active vitamin D analogues suggest a therapeutic option particularly in proteinuric CKD patients. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13476934"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13476934/Neurobiological_model_and_quality_of_life_in_discovering_personality_of_the_uremic_patient"><img alt="Research paper thumbnail of Neurobiological model and quality of life in discovering personality of the uremic patient" class="work-thumbnail" src="https://attachments.academia-assets.com/45295287/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13476934/Neurobiological_model_and_quality_of_life_in_discovering_personality_of_the_uremic_patient">Neurobiological model and quality of life in discovering personality of the uremic patient</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/CarmelaAloisi">Carmela Aloisi</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MicheleBuemi">Michele Buemi</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/AlessioSturiale">Alessio Sturiale</a></span></div><div class="wp-workCard_item"><span>Journal of nephrology</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The Short Form-36 Health Survey (SF-36) questionnaire is designed to measure the patient&#39;s fu...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The Short Form-36 Health Survey (SF-36) questionnaire is designed to measure the patient&#39;s functional capacity and well-being. It was created to reach a compromise between lengthy investigation methods and one dimensional, overly simple tools for measuring quality of life (QoL). In 1987, the psychiatrist Robert Cloninger proposed a psycho-biological model hinged upon three principal and independent dimensions of the human personality: novelty seeking (NS), harm avoidance (HA) and reward dependence (RD), linked with dopaminergic, serotoninergic and noradrenergic activity, respectively. According to Cloninger, each dimension is the expression of the integration of a hereditary condition, characterized by biologic substrates, in response to specific environmental stimuli. We furthermore searched for any interference between the SF-36 scores and plasmatic dopamine, serotonin and noradrenaline concentrations, in an attempt to identify eventual correlations between the condition of th...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7cde378f65c176ffc507c86158396c9f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":45295287,"asset_id":13476934,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/45295287/download_file?st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13476934"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13476934"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13476934; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13476934]").text(description); $(".js-view-count[data-work-id=13476934]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13476934; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13476934']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13476934, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7cde378f65c176ffc507c86158396c9f" } } $('.js-work-strip[data-work-id=13476934]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13476934,"title":"Neurobiological model and quality of life in discovering personality of the uremic patient","translated_title":"","metadata":{"abstract":"The Short Form-36 Health Survey (SF-36) questionnaire is designed to measure the patient\u0026#39;s functional capacity and well-being. 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We furthermore searched for any interference between the SF-36 scores and plasmatic dopamine, serotonin and noradrenaline concentrations, in an attempt to identify eventual correlations between the condition of th...","publication_name":"Journal of nephrology"},"translated_abstract":"The Short Form-36 Health Survey (SF-36) questionnaire is designed to measure the patient\u0026#39;s functional capacity and well-being. It was created to reach a compromise between lengthy investigation methods and one dimensional, overly simple tools for measuring quality of life (QoL). In 1987, the psychiatrist Robert Cloninger proposed a psycho-biological model hinged upon three principal and independent dimensions of the human personality: novelty seeking (NS), harm avoidance (HA) and reward dependence (RD), linked with dopaminergic, serotoninergic and noradrenergic activity, respectively. 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Studies","url":"https://www.academia.edu/Documents/in/Case_Control_Studies"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13383387"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13383387/Aquaporin_2_water_channels_in_spontaneously_hypertensive_rats"><img alt="Research paper thumbnail of Aquaporin-2 water channels in spontaneously hypertensive rats" class="work-thumbnail" src="https://attachments.academia-assets.com/45401125/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13383387/Aquaporin_2_water_channels_in_spontaneously_hypertensive_rats">Aquaporin-2 water channels in spontaneously hypertensive rats</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MicheleBuemi">Michele Buemi</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://magaraibleo.academia.edu/GioacchinoCalapai">Gioacchino Calapai</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/FCorica">Francesco Corica</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/CarmelaAloisi">Carmela Aloisi</a></span></div><div class="wp-workCard_item"><span>American journal of hypertension</span><span>, 2004</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Vasopressin (AVP), an antidiuretic hormone, is known to induce hypervolemia and to regulate the r...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Vasopressin (AVP), an antidiuretic hormone, is known to induce hypervolemia and to regulate the renal expression of aquaporin-2 (AQP2) water channels, but it is not yet known whether the latter are involved in the pathogenesis of essential hypertension. The aim of the present study was therefore to make a comparative study of blood pressure (BP), urinary volume (UV), urinary osmolarity (uOsm), urinary AQP2 (uAQP2), and plasma AVP levels (PAVP) in male spontaneously hypertensive rats (SHR; n = 30) at 3, 7, and 12 weeks of age and in male Wistar-Kyoto rats (WKY, n = 30), also after the subcutaneous administration of OPC-31260 (OPC), a human AVP V(2) receptor antagonist. At 3 weeks, SHR had markedly higher uOsm and lower UV levels than WKY. At 7 weeks, SHR were hypertensive, showing increased uAQP2, PAVP, and uOsm levels and a decreased UV. At 12 weeks, no significant changes were observed in this condition. At 7 and 12 weeks of age, OPC-treated WKY rats showed significant reduction in...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="795eefa7b0a04b51b95d2ac22f7bd008" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":45401125,"asset_id":13383387,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/45401125/download_file?st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13383387"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13383387"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13383387; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13383387]").text(description); $(".js-view-count[data-work-id=13383387]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13383387; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13383387']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13383387, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "795eefa7b0a04b51b95d2ac22f7bd008" } } $('.js-work-strip[data-work-id=13383387]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13383387,"title":"Aquaporin-2 water channels in spontaneously hypertensive rats","translated_title":"","metadata":{"abstract":"Vasopressin (AVP), an antidiuretic hormone, is known to induce hypervolemia and to regulate the renal expression of aquaporin-2 (AQP2) water channels, but it is not yet known whether the latter are involved in the pathogenesis of essential hypertension. The aim of the present study was therefore to make a comparative study of blood pressure (BP), urinary volume (UV), urinary osmolarity (uOsm), urinary AQP2 (uAQP2), and plasma AVP levels (PAVP) in male spontaneously hypertensive rats (SHR; n = 30) at 3, 7, and 12 weeks of age and in male Wistar-Kyoto rats (WKY, n = 30), also after the subcutaneous administration of OPC-31260 (OPC), a human AVP V(2) receptor antagonist. At 3 weeks, SHR had markedly higher uOsm and lower UV levels than WKY. At 7 weeks, SHR were hypertensive, showing increased uAQP2, PAVP, and uOsm levels and a decreased UV. At 12 weeks, no significant changes were observed in this condition. At 7 and 12 weeks of age, OPC-treated WKY rats showed significant reduction in...","publication_date":{"day":null,"month":null,"year":2004,"errors":{}},"publication_name":"American journal of hypertension"},"translated_abstract":"Vasopressin (AVP), an antidiuretic hormone, is known to induce hypervolemia and to regulate the renal expression of aquaporin-2 (AQP2) water channels, but it is not yet known whether the latter are involved in the pathogenesis of essential hypertension. The aim of the present study was therefore to make a comparative study of blood pressure (BP), urinary volume (UV), urinary osmolarity (uOsm), urinary AQP2 (uAQP2), and plasma AVP levels (PAVP) in male spontaneously hypertensive rats (SHR; n = 30) at 3, 7, and 12 weeks of age and in male Wistar-Kyoto rats (WKY, n = 30), also after the subcutaneous administration of OPC-31260 (OPC), a human AVP V(2) receptor antagonist. At 3 weeks, SHR had markedly higher uOsm and lower UV levels than WKY. At 7 weeks, SHR were hypertensive, showing increased uAQP2, PAVP, and uOsm levels and a decreased UV. At 12 weeks, no significant changes were observed in this condition. At 7 and 12 weeks of age, OPC-treated WKY rats showed significant reduction in...","internal_url":"https://www.academia.edu/13383387/Aquaporin_2_water_channels_in_spontaneously_hypertensive_rats","translated_internal_url":"","created_at":"2015-06-28T09:09:07.087-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32610660,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":1750186,"work_id":13383387,"tagging_user_id":32610660,"tagged_user_id":36080295,"co_author_invite_id":497662,"email":"b***m@unime.it","display_order":0,"name":"Michele Buemi","title":"Aquaporin-2 water channels in spontaneously hypertensive rats"},{"id":1750317,"work_id":13383387,"tagging_user_id":32610660,"tagged_user_id":62138897,"co_author_invite_id":523556,"email":"c***f@unime.it","display_order":4194304,"name":"Francesco Corica","title":"Aquaporin-2 water channels in spontaneously hypertensive 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wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13383374/RECOMBINANT_HUMAN_ERYTHROPOIETIN_STIMULATES_ANGIOGENESIS_AND_HEALING_OF_ISCHEMIC_SKIN_WOUNDS">RECOMBINANT HUMAN ERYTHROPOIETIN STIMULATES ANGIOGENESIS AND HEALING OF ISCHEMIC SKIN WOUNDS</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MicheleBuemi">Michele Buemi</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://magaraibleo.academia.edu/GioacchinoCalapai">Gioacchino Calapai</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/CarmelaAloisi">Carmela Aloisi</a></span></div><div class="wp-workCard_item"><span>Shock</span><span>, 2004</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="12ec0954dd5b97b0c1d1165688a88d3e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":45401173,"asset_id":13383374,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/45401173/download_file?st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13383374"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item 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{"id":13383374,"title":"RECOMBINANT HUMAN ERYTHROPOIETIN STIMULATES ANGIOGENESIS AND HEALING OF ISCHEMIC SKIN WOUNDS","translated_title":"","metadata":{"grobid_abstract":"Wound healing in ischemic tissues such as flap margins due to inadequate blood supply is still a source of considerable morbidity in surgical practice. Adequate tissue perfusion is particularly important in wound healing. We investigated the effects of recombinant human erythropoietin (rHuEPO) on wound healing in an ischemic skin wound model. Sixty-three Sprague-Dawley rats were used. Normal incisional wound and H-shaped double flaps were used as the wound models. Animals were treated with rHuEPO (400 IU/kg) or its vehicle. Rats were killed on different days (3, 5, and 10 days after skin injury) and the wounded skin tissues were used for immunohistochemistry and for analysis of vascular endothelial growth factor content and collagen content. Tissue transglutaminase immunostaining of histological specimens was used as a vascular marker to determine the level of microvessel density. The results showed a higher level of vascular endothelial growth factor protein and an increased microvessel density in ischemic wounds with rHuEPO treatment than the normal incisional wounds and ischemic control wounds. Collagen content was higher in the incisional wounds and in the ischemic wounds with rHuEPO treatment compared with the ischemic control wounds. Our results suggest that erythropoietin may be an effective therapeutic approach in improving healing in ischemic skin wounds.","publication_date":{"day":null,"month":null,"year":2004,"errors":{}},"publication_name":"Shock","grobid_abstract_attachment_id":45401173},"translated_abstract":null,"internal_url":"https://www.academia.edu/13383374/RECOMBINANT_HUMAN_ERYTHROPOIETIN_STIMULATES_ANGIOGENESIS_AND_HEALING_OF_ISCHEMIC_SKIN_WOUNDS","translated_internal_url":"","created_at":"2015-06-28T09:09:05.183-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32610660,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":1750190,"work_id":13383374,"tagging_user_id":32610660,"tagged_user_id":36080295,"co_author_invite_id":497662,"email":"b***m@unime.it","display_order":0,"name":"Michele Buemi","title":"RECOMBINANT HUMAN ERYTHROPOIETIN STIMULATES ANGIOGENESIS AND HEALING OF ISCHEMIC SKIN WOUNDS"},{"id":1750250,"work_id":13383374,"tagging_user_id":32610660,"tagged_user_id":null,"co_author_invite_id":523548,"email":"s***o@csnet.it","display_order":4194304,"name":"F. 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Case-control study. Outpatient&#39;s Service for Prevention and Treatment of Obesity at the University Hospital. Body mass index (BMI), waist circumference, hip circumference, waist-to-hip ratio (WHR), fasting plasma glucose, fasting plasma insulin, homeostasis model assessment of insulin resistance (HOMA IR), plasma leptin, TNFalpha, TNF-R1 and TNF-R2 concentrations were evaluated in obese subjects (n = 42) and in age- and gender-matched, lean healthy controls (n = 16). In obese subjects, fasting plasma glucose and insulin, HOMA IR, plasma leptin, TNFalpha, TNF-R1 and TNF-R2 concentrations were significantly higher than in controls. Furthermore, females showed higher leptin, TNF-R1 and TNF-R2 plasma concentrations compared to males, in both control and obese subjects. In control subjects, plasma ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="72297ed99a4d07f228b0f9f7703ceb38" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42414158,"asset_id":16698270,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42414158/download_file?st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="16698270"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="16698270"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16698270; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16698270]").text(description); $(".js-view-count[data-work-id=16698270]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16698270; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='16698270']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 16698270, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "72297ed99a4d07f228b0f9f7703ceb38" } } $('.js-work-strip[data-work-id=16698270]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":16698270,"title":"Relationship between plasma leptin levels and the tumor necrosis factor-alpha system in obese subjects","translated_title":"","metadata":{"abstract":"To evaluate the relationship between plasma leptin and the tumor necrosis factor-alpha (TNFalpha), TNF receptor p60 (TNF-R1) and TNF receptor p80 (TNF-R2) concentrations in obese subjects. 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thumbnail of Experimental Therapies in Renal Replacement: The Effect of Two Different Potassium Acetate-free Biofiltration Protocols on Striated Muscle Fibers" class="work-thumbnail" src="https://attachments.academia-assets.com/39125784/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/16698268/Experimental_Therapies_in_Renal_Replacement_The_Effect_of_Two_Different_Potassium_Acetate_free_Biofiltration_Protocols_on_Striated_Muscle_Fibers">Experimental Therapies in Renal Replacement: The Effect of Two Different Potassium Acetate-free Biofiltration Protocols on Striated Muscle Fibers</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="139238936269898304e19393e2cdc26d" class="wp-workCard--action" rel="nofollow" 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window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16698268]").text(description); $(".js-view-count[data-work-id=16698268]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16698268; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='16698268']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 16698268, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "139238936269898304e19393e2cdc26d" } } $('.js-work-strip[data-work-id=16698268]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":16698268,"title":"Experimental Therapies in Renal Replacement: The Effect of Two Different Potassium Acetate-free Biofiltration Protocols on Striated Muscle Fibers","translated_title":"","metadata":{"grobid_abstract":"Dramatic removal of potassium during hemodialysis sessions can induce changes in the electrical properties of nerve cells or muscle fibers, which may underlie neuromuscular symptoms referred by end-stage renal disease patients. The primary aim of our study was to investigate the effects of acetate-free biofiltration (AFB) on the amplitude of compound motor action potential (cMAP) obtained after stimulation of the ulnar nerve at the wrist. The secondary aim was to compare the effect of two different potassium removal modalities on cMAP amplitude and to analyze the effects on muscular force by specific dynamometric tests. Twenty-eight patients received dialysis for 4 h, 3 times per week, first with standard AFB with constant potassium (AFB) and then with AFB with a variable concentration of potassium in the dialysis bath (AFBK). The amplitude of cMAP was determined after ulnar nerve stimulation at the wrist at different time intervals: at the start of dialysis; at 15, 45, 90, and 120 min after beginning the session; and at the end of treatment. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13613377"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13613377/Effect_of_a_Prostacyclin_Analogue_Iloprost_on_Urinary_Aquaporin_2_Excretion_in_Humans"><img alt="Research paper thumbnail of Effect of a Prostacyclin Analogue, Iloprost, on Urinary Aquaporin-2 Excretion in Humans" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13613377/Effect_of_a_Prostacyclin_Analogue_Iloprost_on_Urinary_Aquaporin_2_Excretion_in_Humans">Effect of a Prostacyclin Analogue, Iloprost, on Urinary Aquaporin-2 Excretion in Humans</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/AlessioSturiale">Alessio Sturiale</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MicheleBuemi">Michele Buemi</a></span></div><div class="wp-workCard_item"><span>Nephron</span><span>, 2002</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The regulation of aquaporin-2 (AQP2) water channel excretion in the collecting duct depends mainl...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The regulation of aquaporin-2 (AQP2) water channel excretion in the collecting duct depends mainly on the action of vasopressin (AVP). Recently, however, other regulatory factors have been identified: atrial natriuretic factor, oxytocin and prostaglandins. In healthy volunteers (5 males, 5 females; mean age 23 +/- 3 years) we therefore evaluated the effect of a stable analogue of prostacyclin-2 (PGI(2)), iloprost, on renal function and on the urinary excretion of AQP2 (U-AQP2). After 6 h of iloprost infusion, U-AQP2 increased from 0.8 +/- 0.15 to 1.8 +/- 0.2 pmol/mg creatinine (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001), while the urinary flow rate increased from 1.4 +/- 0.2 to 1.8 +/- 4 (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.01). No significant change was found in the AVP serum concentration, with a basal value of 3.17 +/- 0.12 vs. 3.15 +/- 0.12 pg/ml after 6 h of prostacyclin infusion. All the values returned to pre-study levels after a recovery period of 6 h. In conclusion, the PGI(2) analogue, iloprost, can induce U-AQP2 excretion independent of AVP.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13613377"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13613377"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13613377; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13613377]").text(description); $(".js-view-count[data-work-id=13613377]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13613377; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13613377']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13613377, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=13613377]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13613377,"title":"Effect of a Prostacyclin Analogue, Iloprost, on Urinary Aquaporin-2 Excretion in Humans","translated_title":"","metadata":{"abstract":"The regulation of aquaporin-2 (AQP2) water channel excretion in the collecting duct depends mainly on the action of vasopressin (AVP). Recently, however, other regulatory factors have been identified: atrial natriuretic factor, oxytocin and prostaglandins. In healthy volunteers (5 males, 5 females; mean age 23 +/- 3 years) we therefore evaluated the effect of a stable analogue of prostacyclin-2 (PGI(2)), iloprost, on renal function and on the urinary excretion of AQP2 (U-AQP2). After 6 h of iloprost infusion, U-AQP2 increased from 0.8 +/- 0.15 to 1.8 +/- 0.2 pmol/mg creatinine (p \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001), while the urinary flow rate increased from 1.4 +/- 0.2 to 1.8 +/- 4 (p \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.01). No significant change was found in the AVP serum concentration, with a basal value of 3.17 +/- 0.12 vs. 3.15 +/- 0.12 pg/ml after 6 h of prostacyclin infusion. All the values returned to pre-study levels after a recovery period of 6 h. In conclusion, the PGI(2) analogue, iloprost, can induce U-AQP2 excretion independent of AVP.","publication_date":{"day":null,"month":null,"year":2002,"errors":{}},"publication_name":"Nephron"},"translated_abstract":"The regulation of aquaporin-2 (AQP2) water channel excretion in the collecting duct depends mainly on the action of vasopressin (AVP). Recently, however, other regulatory factors have been identified: atrial natriuretic factor, oxytocin and prostaglandins. In healthy volunteers (5 males, 5 females; mean age 23 +/- 3 years) we therefore evaluated the effect of a stable analogue of prostacyclin-2 (PGI(2)), iloprost, on renal function and on the urinary excretion of AQP2 (U-AQP2). After 6 h of iloprost infusion, U-AQP2 increased from 0.8 +/- 0.15 to 1.8 +/- 0.2 pmol/mg creatinine (p \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001), while the urinary flow rate increased from 1.4 +/- 0.2 to 1.8 +/- 4 (p \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.01). No significant change was found in the AVP serum concentration, with a basal value of 3.17 +/- 0.12 vs. 3.15 +/- 0.12 pg/ml after 6 h of prostacyclin infusion. All the values returned to pre-study levels after a recovery period of 6 h. In conclusion, the PGI(2) analogue, iloprost, can induce U-AQP2 excretion independent of AVP.","internal_url":"https://www.academia.edu/13613377/Effect_of_a_Prostacyclin_Analogue_Iloprost_on_Urinary_Aquaporin_2_Excretion_in_Humans","translated_internal_url":"","created_at":"2015-07-04T04:49:38.023-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32784653,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":2214349,"work_id":13613377,"tagging_user_id":32784653,"tagged_user_id":32694920,"co_author_invite_id":null,"email":"c***i@unime.it","display_order":0,"name":"Carmela Aloisi","title":"Effect of a Prostacyclin Analogue, Iloprost, on Urinary Aquaporin-2 Excretion in Humans"},{"id":2214400,"work_id":13613377,"tagging_user_id":32784653,"tagged_user_id":36080295,"co_author_invite_id":497662,"email":"b***m@unime.it","display_order":4194304,"name":"Michele Buemi","title":"Effect of a Prostacyclin Analogue, Iloprost, on Urinary Aquaporin-2 Excretion in Humans"}],"downloadable_attachments":[],"slug":"Effect_of_a_Prostacyclin_Analogue_Iloprost_on_Urinary_Aquaporin_2_Excretion_in_Humans","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":32784653,"first_name":"Alessio","middle_initials":null,"last_name":"Sturiale","page_name":"AlessioSturiale","domain_name":"independent","created_at":"2015-07-04T04:48:10.611-07:00","display_name":"Alessio Sturiale","url":"https://independent.academia.edu/AlessioSturiale"},"attachments":[],"research_interests":[{"id":53735,"name":"Oxytocin","url":"https://www.academia.edu/Documents/in/Oxytocin"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":66880,"name":"Aquaporins (AQP)","url":"https://www.academia.edu/Documents/in/Aquaporins_AQP_"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology"},{"id":227354,"name":"Renal Function","url":"https://www.academia.edu/Documents/in/Renal_Function"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":325753,"name":"Water Channel","url":"https://www.academia.edu/Documents/in/Water_Channel"},{"id":382075,"name":"Adult","url":"https://www.academia.edu/Documents/in/Adult"},{"id":443927,"name":"Aquaporin","url":"https://www.academia.edu/Documents/in/Aquaporin"},{"id":898062,"name":"Flow Rate","url":"https://www.academia.edu/Documents/in/Flow_Rate"},{"id":1438730,"name":"Creatinine","url":"https://www.academia.edu/Documents/in/Creatinine"},{"id":1626168,"name":"Prostaglandin E2","url":"https://www.academia.edu/Documents/in/Prostaglandin_E2"},{"id":2015813,"name":"Atrial Natriuretic Factor","url":"https://www.academia.edu/Documents/in/Atrial_Natriuretic_Factor"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13476933"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13476933/Reduced_bcl_2_concentrations_in_hypertensive_patients_after_lisinopril_or_nifedipine_administration"><img alt="Research paper thumbnail of Reduced bcl-2 concentrations in hypertensive patients after lisinopril or nifedipine administration" class="work-thumbnail" src="https://attachments.academia-assets.com/45295326/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13476933/Reduced_bcl_2_concentrations_in_hypertensive_patients_after_lisinopril_or_nifedipine_administration">Reduced bcl-2 concentrations in hypertensive patients after lisinopril or nifedipine administration</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MicheleBuemi">Michele Buemi</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/CarmelaAloisi">Carmela Aloisi</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/FCorica">Francesco Corica</a></span></div><div class="wp-workCard_item"><span>American Journal of Hypertension</span><span>, 1999</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="afbf87fd2b4efd859a978d779ed24adc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":45295326,"asset_id":13476933,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/45295326/download_file?st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13476933"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13476933"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13476933; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "afbf87fd2b4efd859a978d779ed24adc" } } $('.js-work-strip[data-work-id=13476933]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13476933,"title":"Reduced bcl-2 concentrations in hypertensive patients after lisinopril or nifedipine administration","translated_title":"","metadata":{"grobid_abstract":"In 30 patients with essential hypertension and 30 healthy control subjects, we evaluated blood concentrations of B cell leukemia-2 (bcl-2), a protooncogene that can reduce apoptosis. Bcl-2 concentrations were higher in hypertensive than in normotensive subjects. The increase in pressure due to a cold pressor test caused a further increase in blood bcl-2 concentrations, in both hypertensive and normotensive subjects. Treatment of hypertensive patients with hypotensive drugs caused a reduction in bcl-2 concentrations, which was more marked after administration of lisinopril than of nifedipine. The results suggest that concentrations of bcl-2 are increased in patients with hypertension, which could be an important factor in cell proliferation underlying posthypertensive vascular remodeling. Moreover, lisinopril and nifedipine appear to be capable of reducing bcl-2 concentrations, with potentially beneficial effects on vascular modifications in patients with hypertension. 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href="https://www.academia.edu/16698259/Obstruction_of_the_Subclavian_Vein_due_to_Placement_of_a_Hemodialysis_Cathether_in_a_Subject_with_Thoracic_Outlet_Syndrome">Obstruction of the Subclavian Vein due to Placement of a Hemodialysis Cathether in a Subject with Thoracic Outlet Syndrome</a></div><div class="wp-workCard_item"><span>Nephron</span><span>, 1994</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="16698259"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" 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href="https://www.academia.edu/16698258/Genomic_damage_in_endothelial_progenitor_cells_from_uremic_patients_in_hemodialysis">Genomic damage in endothelial progenitor cells from uremic patients in hemodialysis</a></div><div class="wp-workCard_item"><span>Journal of nephrology</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">End stage renal disease (ESRD) is associated with a high incidence of cardiovascular disease and ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">End stage renal disease (ESRD) is associated with a high incidence of cardiovascular disease and cancer. Patients undergoing hemodialysis show a reduced number and an impaired function of endothelial progenitor cells (EPCs), which in physiological conditions contribute to repair the vascular damage. In patients with ESRD, massive oxidative genome damage has been demonstrated but the role of HD in causing it is still a controversial issue. The aim of our study was to analyze the effects of a single HD session on the number of cells marked with CD34 (including sub-type cells known to be EPCs); we then evaluated the genomic damage in these cells using COMET assay. We quantified CD34(+) cells in blood samples in 30 patients in hemodiafiltration treatment for 3.5 to 4 hours 3 times/week and in 30 healthy volunteers. In HD patients, blood samples were drawn at different time intervals: start of dialysis (T(0)), at the end of the treatment (T(end)) and 24 hours afterwards in the interdialy...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9ce09c9c03bcf4a2e45fe79b67556ad4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39125781,"asset_id":16698258,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39125781/download_file?st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="16698258"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="16698258"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16698258; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16698258]").text(description); $(".js-view-count[data-work-id=16698258]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16698258; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='16698258']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 16698258, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9ce09c9c03bcf4a2e45fe79b67556ad4" } } $('.js-work-strip[data-work-id=16698258]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":16698258,"title":"Genomic damage in endothelial progenitor cells from uremic patients in hemodialysis","translated_title":"","metadata":{"abstract":"End stage renal disease (ESRD) is associated with a high incidence of cardiovascular disease and cancer. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="16698257"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/16698257/Chromosomal_damage_and_atherosclerosis_A_protective_effect_from_simvastatin"><img alt="Research paper thumbnail of Chromosomal damage and atherosclerosis. A protective effect from simvastatin" class="work-thumbnail" src="https://attachments.academia-assets.com/42414180/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/16698257/Chromosomal_damage_and_atherosclerosis_A_protective_effect_from_simvastatin">Chromosomal damage and atherosclerosis. A protective effect from simvastatin</a></div><div class="wp-workCard_item"><span>European Journal of Pharmacology</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In uremic patients, the frequency of sister chromatid exchanges appears markedly higher than in t...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In uremic patients, the frequency of sister chromatid exchanges appears markedly higher than in the general population. Statins are well known for their pleiotropic effects, which are independent of any reduction in cholesterol circulating levels. The aim of the present study was to determine the effects of exposure to escalating doses of simvastatin on the sister chromatid exchange rate in</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4bd557752843729e92d428f417d1f564" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42414180,"asset_id":16698257,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42414180/download_file?st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="16698257"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="16698257"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16698257; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16698257]").text(description); $(".js-view-count[data-work-id=16698257]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16698257; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='16698257']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 16698257, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4bd557752843729e92d428f417d1f564" } } $('.js-work-strip[data-work-id=16698257]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":16698257,"title":"Chromosomal damage and atherosclerosis. 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The aim of the present study was to determine the effects of exposure to escalating doses of simvastatin on the sister chromatid exchange rate in","internal_url":"https://www.academia.edu/16698257/Chromosomal_damage_and_atherosclerosis_A_protective_effect_from_simvastatin","translated_internal_url":"","created_at":"2015-10-12T07:38:51.340-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36080295,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":42414180,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42414180/thumbnails/1.jpg","file_name":"j.ejphar.2006.01.003.pdf20160208-1144-1jsqlvo","download_url":"https://www.academia.edu/attachments/42414180/download_file?st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Chromosomal_damage_and_atherosclerosis_A.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42414180/j.ejphar.2006.01.003-libre.pdf20160208-1144-1jsqlvo?1454976471=\u0026response-content-disposition=attachment%3B+filename%3DChromosomal_damage_and_atherosclerosis_A.pdf\u0026Expires=1732416356\u0026Signature=YWEUaHZmLwLxGfIltGi8waVByInEI3KZWpzE6-pMCpPTHR7ggyDO1cO0iL9kFzBQFhu7NhnRUZWWF2cNNfXV7dQii4auuWhlHvslBj24pMFktmVaQXqRYCRRap9fU64wIHISocy07RGP28Lcj6gv63V8aTFeuPwxbfHqHk~2tuu0ECccSBtGTuGfBpwIKJHiJS2kcilVqFwD0sBnTyfsDmRO0c~~jGKxlNPH7nthzF18lEJdeV7CVKuBoIeW4WfW6V8yd~GQMl6dn76Ll6aBk0~M4Wst6ZzRUFRC-qKOMBmTA-f6dtIO6YHF7S2T5t-PiNCx4LMSWmS4mGrb8AN99g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Chromosomal_damage_and_atherosclerosis_A_protective_effect_from_simvastatin","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":36080295,"first_name":"Michele","middle_initials":null,"last_name":"Buemi","page_name":"MicheleBuemi","domain_name":"independent","created_at":"2015-10-12T07:37:32.970-07:00","display_name":"Michele Buemi","url":"https://independent.academia.edu/MicheleBuemi"},"attachments":[{"id":42414180,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42414180/thumbnails/1.jpg","file_name":"j.ejphar.2006.01.003.pdf20160208-1144-1jsqlvo","download_url":"https://www.academia.edu/attachments/42414180/download_file?st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Chromosomal_damage_and_atherosclerosis_A.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42414180/j.ejphar.2006.01.003-libre.pdf20160208-1144-1jsqlvo?1454976471=\u0026response-content-disposition=attachment%3B+filename%3DChromosomal_damage_and_atherosclerosis_A.pdf\u0026Expires=1732416356\u0026Signature=YWEUaHZmLwLxGfIltGi8waVByInEI3KZWpzE6-pMCpPTHR7ggyDO1cO0iL9kFzBQFhu7NhnRUZWWF2cNNfXV7dQii4auuWhlHvslBj24pMFktmVaQXqRYCRRap9fU64wIHISocy07RGP28Lcj6gv63V8aTFeuPwxbfHqHk~2tuu0ECccSBtGTuGfBpwIKJHiJS2kcilVqFwD0sBnTyfsDmRO0c~~jGKxlNPH7nthzF18lEJdeV7CVKuBoIeW4WfW6V8yd~GQMl6dn76Ll6aBk0~M4Wst6ZzRUFRC-qKOMBmTA-f6dtIO6YHF7S2T5t-PiNCx4LMSWmS4mGrb8AN99g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":8015,"name":"Atherosclerosis","url":"https://www.academia.edu/Documents/in/Atherosclerosis"},{"id":48458,"name":"High Frequency","url":"https://www.academia.edu/Documents/in/High_Frequency"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":85188,"name":"End Stage Renal Disease","url":"https://www.academia.edu/Documents/in/End_Stage_Renal_Disease"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European"},{"id":295155,"name":"Middle Aged","url":"https://www.academia.edu/Documents/in/Middle_Aged"},{"id":868560,"name":"Lymphocytes","url":"https://www.academia.edu/Documents/in/Lymphocytes"},{"id":1106287,"name":"Chronic Kidney Failure","url":"https://www.academia.edu/Documents/in/Chronic_Kidney_Failure"},{"id":1168109,"name":"Mitotic Index","url":"https://www.academia.edu/Documents/in/Mitotic_Index"},{"id":1315270,"name":"Simvastatin","url":"https://www.academia.edu/Documents/in/Simvastatin"},{"id":1423006,"name":"General Population","url":"https://www.academia.edu/Documents/in/General_Population"}],"urls":[{"id":5938399,"url":"http://www.sciencedirect.com/science/article/pii/S0014299906000112"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="16698254"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/16698254/Dialysis_related_genotoxicity_sister_chromatid_exchanges_and_DNA_lesions_in_T_and_B_lymphocytes_of_uremic_patients_Genomic_damage_in_patients_on_hemodiafiltration"><img alt="Research paper thumbnail of Dialysis-related genotoxicity: sister chromatid exchanges and DNA lesions in T and B lymphocytes of uremic patients. Genomic damage in patients on hemodiafiltration" class="work-thumbnail" src="https://attachments.academia-assets.com/39125778/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/16698254/Dialysis_related_genotoxicity_sister_chromatid_exchanges_and_DNA_lesions_in_T_and_B_lymphocytes_of_uremic_patients_Genomic_damage_in_patients_on_hemodiafiltration">Dialysis-related genotoxicity: sister chromatid exchanges and DNA lesions in T and B lymphocytes of uremic patients. Genomic damage in patients on hemodiafiltration</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8a606d49a3f1b70bfe812e7e060db405" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39125778,"asset_id":16698254,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39125778/download_file?st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="16698254"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="16698254"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16698254; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16698254]").text(description); $(".js-view-count[data-work-id=16698254]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16698254; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='16698254']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 16698254, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8a606d49a3f1b70bfe812e7e060db405" } } $('.js-work-strip[data-work-id=16698254]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":16698254,"title":"Dialysis-related genotoxicity: sister chromatid exchanges and DNA lesions in T and B lymphocytes of uremic patients. Genomic damage in patients on hemodiafiltration","translated_title":"","metadata":{"grobid_abstract":"Background/Aims: Patients with chronic renal failure show the presence of massive oxidative genome damage but the role played by dialysis is still a controversial issue. The aim of our study was to verify the genomic damage in B-and T-lymphocyte subpopulations of uremic patients after a single hemodiafiltration session. Methods: We enrolled 30 patients on maintenance acetate-free biofiltration and 25 agematched healthy volunteers and studied chromosomal alterations. Results: Our data show that the basal levels of DNA damage, the number of sister chromatid exchanges and basal high-frequency cells levels are significantly higher in patients on hemodiafiltration than in controls and in T lymphocytes than in B cells. Conclusions: These findings suggest that hemodialytic treatment could represent a potential source of damage, maybe through the oxidative action of the extracorporeal circuit components, which might explain the well-known T-specific immunodeficiency correlated with uremia.","publication_date":{"day":null,"month":null,"year":2006,"errors":{}},"grobid_abstract_attachment_id":39125778},"translated_abstract":null,"internal_url":"https://www.academia.edu/16698254/Dialysis_related_genotoxicity_sister_chromatid_exchanges_and_DNA_lesions_in_T_and_B_lymphocytes_of_uremic_patients_Genomic_damage_in_patients_on_hemodiafiltration","translated_internal_url":"","created_at":"2015-10-12T07:38:50.838-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36080295,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":39125778,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/39125778/thumbnails/1.jpg","file_name":"09e41509d0a1e4c317000000.pdf","download_url":"https://www.academia.edu/attachments/39125778/download_file?st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Dialysis_related_genotoxicity_sister_chr.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/39125778/09e41509d0a1e4c317000000-libre.pdf?1444660762=\u0026response-content-disposition=attachment%3B+filename%3DDialysis_related_genotoxicity_sister_chr.pdf\u0026Expires=1732394066\u0026Signature=btyrTmrkNffbCjvnGcX4R2yN9MukKTC5Ice9BzlHCH469I2u8aNwyXa31z9QO11jojULJUOXYK-ihKm4dN-nk9GR57DKO0sMeTT-gvrUDeOuDBhWFgV4GVPe96dOryGn7FbtZjcDJ40w8GHdXvZ4MHXMc32e5UVme8fJ8kb87-z-WtGmZglePElkX6o-6yj0nf3ERKtPi4cuSdaBIu1YMrhRgsR6H65d~TRPBnQOv537p31VzfP7FV0g60hwYiCf~mMi~sJBWYadeg~XRe5B6C6BrMfwrISbrSqkfrKiBqHgGQilDyMiPs~9ERxPddDiXKY0jWqP6ODO1omUrnvzRg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Dialysis_related_genotoxicity_sister_chromatid_exchanges_and_DNA_lesions_in_T_and_B_lymphocytes_of_uremic_patients_Genomic_damage_in_patients_on_hemodiafiltration","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":36080295,"first_name":"Michele","middle_initials":null,"last_name":"Buemi","page_name":"MicheleBuemi","domain_name":"independent","created_at":"2015-10-12T07:37:32.970-07:00","display_name":"Michele Buemi","url":"https://independent.academia.edu/MicheleBuemi"},"attachments":[{"id":39125778,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/39125778/thumbnails/1.jpg","file_name":"09e41509d0a1e4c317000000.pdf","download_url":"https://www.academia.edu/attachments/39125778/download_file?st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Dialysis_related_genotoxicity_sister_chr.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/39125778/09e41509d0a1e4c317000000-libre.pdf?1444660762=\u0026response-content-disposition=attachment%3B+filename%3DDialysis_related_genotoxicity_sister_chr.pdf\u0026Expires=1732394066\u0026Signature=btyrTmrkNffbCjvnGcX4R2yN9MukKTC5Ice9BzlHCH469I2u8aNwyXa31z9QO11jojULJUOXYK-ihKm4dN-nk9GR57DKO0sMeTT-gvrUDeOuDBhWFgV4GVPe96dOryGn7FbtZjcDJ40w8GHdXvZ4MHXMc32e5UVme8fJ8kb87-z-WtGmZglePElkX6o-6yj0nf3ERKtPi4cuSdaBIu1YMrhRgsR6H65d~TRPBnQOv537p31VzfP7FV0g60hwYiCf~mMi~sJBWYadeg~XRe5B6C6BrMfwrISbrSqkfrKiBqHgGQilDyMiPs~9ERxPddDiXKY0jWqP6ODO1omUrnvzRg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":23066,"name":"DNA damage","url":"https://www.academia.edu/Documents/in/DNA_damage"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":279382,"name":"Comet Assay","url":"https://www.academia.edu/Documents/in/Comet_Assay"},{"id":280237,"name":"T lymphocytes","url":"https://www.academia.edu/Documents/in/T_lymphocytes"},{"id":295155,"name":"Middle Aged","url":"https://www.academia.edu/Documents/in/Middle_Aged"},{"id":678853,"name":"B Lymphocytes","url":"https://www.academia.edu/Documents/in/B_Lymphocytes"},{"id":1106287,"name":"Chronic Kidney Failure","url":"https://www.academia.edu/Documents/in/Chronic_Kidney_Failure"}],"urls":[{"id":5938398,"url":"http://content.karger.com/ProdukteDB/produkte.asp?doi=10.1159/000097080"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13476932"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13476932/C010_The_serum_of_patients_treated_with_fluvastatin_induces_apoptosis_in_human_monocitoid_cells"><img alt="Research paper thumbnail of C010 The serum of patients treated with fluvastatin induces apoptosis in human monocitoid cells" class="work-thumbnail" src="https://attachments.academia-assets.com/45295297/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13476932/C010_The_serum_of_patients_treated_with_fluvastatin_induces_apoptosis_in_human_monocitoid_cells">C010 The serum of patients treated with fluvastatin induces apoptosis in human monocitoid cells</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MicheleBuemi">Michele Buemi</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/CarmelaAloisi">Carmela Aloisi</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/FCorica">Francesco Corica</a></span></div><div class="wp-workCard_item"><span>American Journal of Hypertension</span><span>, 1998</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7897b8aae675b9d26aa4994f8572f4e1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":45295297,"asset_id":13476932,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/45295297/download_file?st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13476932"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13476932"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13476932; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="16698251"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/16698251/Vitamin_D_Receptor_Polymorphism_in_Chronic_Kidney_Disease_Patients_With_Complicated_Cardiovascular_Disease"><img alt="Research paper thumbnail of Vitamin D Receptor Polymorphism in Chronic Kidney Disease Patients With Complicated Cardiovascular Disease" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/16698251/Vitamin_D_Receptor_Polymorphism_in_Chronic_Kidney_Disease_Patients_With_Complicated_Cardiovascular_Disease">Vitamin D Receptor Polymorphism in Chronic Kidney Disease Patients With Complicated Cardiovascular Disease</a></div><div class="wp-workCard_item"><span>Journal of Renal Nutrition</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Several studies indicate a relationship between vitamin D and cardiovascular disease. Pleiotropic...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Several studies indicate a relationship between vitamin D and cardiovascular disease. Pleiotropic actions of vitamin D and its analogs are mediated by vitamin D receptor (VDR). VDRs have been identified in almost all tissues, including vascular smooth muscle cells, cardiomyocytes, and endothelial cells. The FokI and BsmI polymorphisms of the VDR gene are regarded as strong markers of disturbed vitamin D signaling pathway. Studies investigating the relationship between VDR genotypes and left ventricular hypertrophy revealed a highly significant association with the BsmI Bb heterozygous genotype. There are conflicting data on the action of vitamin D in left ventricular hypertrophy. Experimental as well as observational studies and small clinical trials have suggested that vitamin D administration may favorably influence left ventricular hypertrophy, whereas large randomized clinical trials have shown negative results. However, a beneficial effect on the left atrial volume index and the duration of hospitalization were observed in patients treated with vitamin D analogs. Larger clinical trials with robust clinical end points are needed to confirm that vitamin D is effective in preventing cardiovascular disease in chronic kidney disease patients and in general population.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="16698251"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="16698251"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16698251; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16698251]").text(description); $(".js-view-count[data-work-id=16698251]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16698251; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='16698251']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 16698251, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=16698251]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":16698251,"title":"Vitamin D Receptor Polymorphism in Chronic Kidney Disease Patients With Complicated Cardiovascular Disease","translated_title":"","metadata":{"abstract":"Several studies indicate a relationship between vitamin D and cardiovascular disease. Pleiotropic actions of vitamin D and its analogs are mediated by vitamin D receptor (VDR). VDRs have been identified in almost all tissues, including vascular smooth muscle cells, cardiomyocytes, and endothelial cells. The FokI and BsmI polymorphisms of the VDR gene are regarded as strong markers of disturbed vitamin D signaling pathway. Studies investigating the relationship between VDR genotypes and left ventricular hypertrophy revealed a highly significant association with the BsmI Bb heterozygous genotype. There are conflicting data on the action of vitamin D in left ventricular hypertrophy. Experimental as well as observational studies and small clinical trials have suggested that vitamin D administration may favorably influence left ventricular hypertrophy, whereas large randomized clinical trials have shown negative results. However, a beneficial effect on the left atrial volume index and the duration of hospitalization were observed in patients treated with vitamin D analogs. Larger clinical trials with robust clinical end points are needed to confirm that vitamin D is effective in preventing cardiovascular disease in chronic kidney disease patients and in general population.","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Journal of Renal Nutrition"},"translated_abstract":"Several studies indicate a relationship between vitamin D and cardiovascular disease. Pleiotropic actions of vitamin D and its analogs are mediated by vitamin D receptor (VDR). VDRs have been identified in almost all tissues, including vascular smooth muscle cells, cardiomyocytes, and endothelial cells. The FokI and BsmI polymorphisms of the VDR gene are regarded as strong markers of disturbed vitamin D signaling pathway. Studies investigating the relationship between VDR genotypes and left ventricular hypertrophy revealed a highly significant association with the BsmI Bb heterozygous genotype. There are conflicting data on the action of vitamin D in left ventricular hypertrophy. Experimental as well as observational studies and small clinical trials have suggested that vitamin D administration may favorably influence left ventricular hypertrophy, whereas large randomized clinical trials have shown negative results. However, a beneficial effect on the left atrial volume index and the duration of hospitalization were observed in patients treated with vitamin D analogs. Larger clinical trials with robust clinical end points are needed to confirm that vitamin D is effective in preventing cardiovascular disease in chronic kidney disease patients and in general population.","internal_url":"https://www.academia.edu/16698251/Vitamin_D_Receptor_Polymorphism_in_Chronic_Kidney_Disease_Patients_With_Complicated_Cardiovascular_Disease","translated_internal_url":"","created_at":"2015-10-12T07:38:50.199-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36080295,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Vitamin_D_Receptor_Polymorphism_in_Chronic_Kidney_Disease_Patients_With_Complicated_Cardiovascular_Disease","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":36080295,"first_name":"Michele","middle_initials":null,"last_name":"Buemi","page_name":"MicheleBuemi","domain_name":"independent","created_at":"2015-10-12T07:37:32.970-07:00","display_name":"Michele Buemi","url":"https://independent.academia.edu/MicheleBuemi"},"attachments":[],"research_interests":[{"id":591,"name":"Nutrition and Dietetics","url":"https://www.academia.edu/Documents/in/Nutrition_and_Dietetics"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":408710,"name":"Renal Nutrition","url":"https://www.academia.edu/Documents/in/Renal_Nutrition"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="3732407" id="papers"><div class="js-work-strip profile--work_container" data-work-id="16698280"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/16698280/Neurokinin_B_and_nitric_oxide_plasma_levels_in_pre_eclampsia_and_isolated_intrauterine_growth_restriction"><img alt="Research paper thumbnail of Neurokinin B and nitric oxide plasma levels in pre-eclampsia and isolated intrauterine growth restriction" class="work-thumbnail" src="https://attachments.academia-assets.com/42414150/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/16698280/Neurokinin_B_and_nitric_oxide_plasma_levels_in_pre_eclampsia_and_isolated_intrauterine_growth_restriction">Neurokinin B and nitric oxide plasma levels in pre-eclampsia and isolated intrauterine growth restriction</a></div><div class="wp-workCard_item"><span>Bjog-an International Journal of Obstetrics and Gynaecology</span><span>, 2004</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9939c9edf7930059391126e80122dc40" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42414150,"asset_id":16698280,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42414150/download_file?st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="16698280"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="16698280"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16698280; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16698280]").text(description); $(".js-view-count[data-work-id=16698280]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16698280; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='16698280']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 16698280, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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Also, to ascertain if there is a correlation between neurokinin B plasma level and nitric oxide production. Design A total of 90 pregnant women were studied. Thirty had a gestation complicated by pre-eclampsia and 30 by isolated IUGR; the other 30 were controls. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13476935"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13476935/Is_apoptosis_cause_of_pre_eclampsia"><img alt="Research paper thumbnail of Is apoptosis cause of pre-eclampsia?" class="work-thumbnail" src="https://attachments.academia-assets.com/38057511/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13476935/Is_apoptosis_cause_of_pre_eclampsia">Is apoptosis cause of pre-eclampsia?</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MicheleBuemi">Michele Buemi</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/CarmelaAloisi">Carmela Aloisi</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/FCorica">Francesco Corica</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RosarioDAnna">Rosario D'Anna</a></span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Pre-eclampsia is the main cause of fetal and maternal morbidity and death associated with hyperte...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Pre-eclampsia is the main cause of fetal and maternal morbidity and death associated with hypertension during complicat- ing pregnancy. During physiological pregnancy, the immuno- logical system undergoes secondary modifica- tions, with an &quot;exchange&quot; between mother and fetus. Cytokines play an important role in the com- plex condition of partial fetal &quot;rejection&quot;. It has suggested that the condition depend on im-</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8397bf3298cf1bed33eb52d62264d2af" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":38057511,"asset_id":13476935,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/38057511/download_file?st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13476935"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13476935"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13476935; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13476935]").text(description); $(".js-view-count[data-work-id=13476935]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13476935; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13476935']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13476935, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8397bf3298cf1bed33eb52d62264d2af" } } $('.js-work-strip[data-work-id=13476935]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13476935,"title":"Is apoptosis cause of pre-eclampsia?","translated_title":"","metadata":{"abstract":"Pre-eclampsia is the main cause of fetal and maternal morbidity and death associated with hypertension during complicat- ing pregnancy. 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src="https://attachments.academia-assets.com/42414161/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/16698277/Impaired_antiviral_activity_of_monocytes_from_patients_on_hemodiafiltration">Impaired antiviral activity of monocytes from patients on hemodiafiltration</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c6cf66a70fa1cef7673a47bc9894ba03" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42414161,"asset_id":16698277,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42414161/download_file?st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa 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cytokines such as interleukin-12 (IL-12), tumor necrosis factor-α (TNF-α) and interferon-α (IFN-α) by the same cells. Methods: We enrolled 25 patients undergoing HDF for 3.5-4 hours 3 times a week (12 men, 13 women; mean age 58 ± 6.7 years) and 25 healthy donors (ND) (12 men, 13 women; mean age 57 ± 8 years). Monocytes from peripheral blood mononuclear cells were isolated with a Monocyte Isolation Kit II. Monocytic cells were infected with herpes simplex virus type 2 (HSV-2). Cytokines were assayed in supernatants. Results: The in vitro antiviral activity of monocytes from HDF patients was significantly impaired with respect to ND. Furthermore, monocytes from post-HDF patients were more prone to viral infection.","publication_date":{"day":null,"month":null,"year":2007,"errors":{}},"grobid_abstract_attachment_id":42414161},"translated_abstract":null,"internal_url":"https://www.academia.edu/16698277/Impaired_antiviral_activity_of_monocytes_from_patients_on_hemodiafiltration","translated_internal_url":"","created_at":"2015-10-12T07:38:56.643-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36080295,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":42414161,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42414161/thumbnails/1.jpg","file_name":"Impaired_antiviral_activity_of_monocytes20160208-16427-1f0cs86.pdf","download_url":"https://www.academia.edu/attachments/42414161/download_file?st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Impaired_antiviral_activity_of_monocytes.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42414161/Impaired_antiviral_activity_of_monocytes20160208-16427-1f0cs86-libre.pdf?1454976472=\u0026response-content-disposition=attachment%3B+filename%3DImpaired_antiviral_activity_of_monocytes.pdf\u0026Expires=1732394066\u0026Signature=gG0m6YCydAlZRN8xY4sgvHYeIcXJpg3e~8d1eIDfpgpb74peI9e2DtTUoZ8oAgYj7mjTWqvRiyJ6t~hrYdvUPtpK2TxMqvOtkyDTeS-2AAsra~vD4myOOjCEHDrr3rZYr6YOuv1zN1l4DJrQTN56GsV3~gb16k2f3c2tKyKviNhGFPwj31qJsvY~oea-LI0EuzJc4MSNEElpfsGaqyX2Jz3U-P5rZfeRNasCotCmgglIRKRSTtEDnFydtrtGmSMi14vHd2xQTDFgzgnww0-ML8uIvOkoIaIFqZvw3KS4H6Q1QHSX8CH0a1r8-frbR2ulF8BIfEN4eZbjM9UdPEuEig__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Impaired_antiviral_activity_of_monocytes_from_patients_on_hemodiafiltration","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":36080295,"first_name":"Michele","middle_initials":null,"last_name":"Buemi","page_name":"MicheleBuemi","domain_name":"independent","created_at":"2015-10-12T07:37:32.970-07:00","display_name":"Michele 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diseases","url":"https://www.academia.edu/Documents/in/Kidney_diseases"},{"id":9111,"name":"Cytokines","url":"https://www.academia.edu/Documents/in/Cytokines"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":295155,"name":"Middle Aged","url":"https://www.academia.edu/Documents/in/Middle_Aged"},{"id":335983,"name":"Lipopolysaccharides","url":"https://www.academia.edu/Documents/in/Lipopolysaccharides"},{"id":402972,"name":"Monocytes","url":"https://www.academia.edu/Documents/in/Monocytes"},{"id":474029,"name":"Tumor necrosis factor-alpha","url":"https://www.academia.edu/Documents/in/Tumor_necrosis_factor-alpha"},{"id":902999,"name":"Antiviral 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class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/16698275/Interplay_of_Vitamin_D_Erythropoiesis_and_the_Renin_Angiotensin_System"><img alt="Research paper thumbnail of Interplay of Vitamin D, Erythropoiesis, and the Renin-Angiotensin System" class="work-thumbnail" src="https://attachments.academia-assets.com/39125785/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/16698275/Interplay_of_Vitamin_D_Erythropoiesis_and_the_Renin_Angiotensin_System">Interplay of Vitamin D, Erythropoiesis, and the Renin-Angiotensin System</a></div><div class="wp-workCard_item"><span>BioMed Research International</span><span>, 2015</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="95f789ec8251c16e13c162ce47397d8b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39125785,"asset_id":16698275,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39125785/download_file?st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="16698275"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="16698275"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16698275; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16698275]").text(description); $(".js-view-count[data-work-id=16698275]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16698275; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='16698275']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 16698275, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "95f789ec8251c16e13c162ce47397d8b" } } $('.js-work-strip[data-work-id=16698275]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":16698275,"title":"Interplay of Vitamin D, Erythropoiesis, and the Renin-Angiotensin System","translated_title":"","metadata":{"grobid_abstract":"For many years deficiency of vitamin D was merely identified and assimilated to the presence of bone rickets. It is now clear that suboptimal vitamin D status may be correlated with several disorders and that the expression of 1--hydroxylase in tissues other than the kidney is widespread and of clinical relevance. Recently, evidence has been collected to suggest that, beyond the traditional involvement in mineral metabolism, vitamin D may interact with other kidney hormones such as renin and erythropoietin. This interaction would be responsible for some of the systemic and renal effects evoked for the therapy with vitamin D. The administration of analogues of vitamin D has been associated with an improvement of anaemia and reduction in ESA requirements. Moreover, vitamin D deficiency could contribute to an inappropriately activated or unsuppressed RAS, as a mechanism for progression of CKD and/or cardiovascular disease. Experimental data on the anti-RAS and anti-inflammatory effects treatment with active vitamin D analogues suggest a therapeutic option particularly in proteinuric CKD patients. This option should be considered for those subjects that are intolerant to anti-RAS agents or, as add-on therapy, in those already treated with anti-RAS but not reaching the safe threshold level of proteinuria.","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"BioMed Research International","grobid_abstract_attachment_id":39125785},"translated_abstract":null,"internal_url":"https://www.academia.edu/16698275/Interplay_of_Vitamin_D_Erythropoiesis_and_the_Renin_Angiotensin_System","translated_internal_url":"","created_at":"2015-10-12T07:38:56.117-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36080295,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":39125785,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/39125785/thumbnails/1.jpg","file_name":"553f83770cf2574dcf629bcd.pdf","download_url":"https://www.academia.edu/attachments/39125785/download_file?st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Interplay_of_Vitamin_D_Erythropoiesis_an.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/39125785/553f83770cf2574dcf629bcd-libre.pdf?1444660762=\u0026response-content-disposition=attachment%3B+filename%3DInterplay_of_Vitamin_D_Erythropoiesis_an.pdf\u0026Expires=1732394066\u0026Signature=a~GdcLlOEKFz3e07bHdbDQ2cm47taNSRiO9mBFoaBKhU7jBMQH7M8CCX~knkSugpTBJKCjKvgMQK-q7QLtbnzvtVDmzsZv6xE0i40~iYr6VUvuh~4AmlcE2nEMDjI2~4Js83NUPeqHW9wCDuKSjult8JyxVdmq7sqiDSr~GBDWIZkpkdJXHWgW89VNSzoKLvJnrHC5yXHGEDdOubwBe4qrVk2Zhxe-zWWCpgzpFLsaNtCbtZToNlKRWnb6DnUOJoNrFsBIsHQFYSEImHKTpjJVBi4-Y-GkzRVBWu502Z6vDHxePqGOidruE4vYGgz7HXeVbL~T9coKlLBzVSCIOBkA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Interplay_of_Vitamin_D_Erythropoiesis_and_the_Renin_Angiotensin_System","translated_slug":"","page_count":12,"language":"en","content_type":"Work","owner":{"id":36080295,"first_name":"Michele","middle_initials":null,"last_name":"Buemi","page_name":"MicheleBuemi","domain_name":"independent","created_at":"2015-10-12T07:37:32.970-07:00","display_name":"Michele Buemi","url":"https://independent.academia.edu/MicheleBuemi"},"attachments":[{"id":39125785,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/39125785/thumbnails/1.jpg","file_name":"553f83770cf2574dcf629bcd.pdf","download_url":"https://www.academia.edu/attachments/39125785/download_file?st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Interplay_of_Vitamin_D_Erythropoiesis_an.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/39125785/553f83770cf2574dcf629bcd-libre.pdf?1444660762=\u0026response-content-disposition=attachment%3B+filename%3DInterplay_of_Vitamin_D_Erythropoiesis_an.pdf\u0026Expires=1732394066\u0026Signature=a~GdcLlOEKFz3e07bHdbDQ2cm47taNSRiO9mBFoaBKhU7jBMQH7M8CCX~knkSugpTBJKCjKvgMQK-q7QLtbnzvtVDmzsZv6xE0i40~iYr6VUvuh~4AmlcE2nEMDjI2~4Js83NUPeqHW9wCDuKSjult8JyxVdmq7sqiDSr~GBDWIZkpkdJXHWgW89VNSzoKLvJnrHC5yXHGEDdOubwBe4qrVk2Zhxe-zWWCpgzpFLsaNtCbtZToNlKRWnb6DnUOJoNrFsBIsHQFYSEImHKTpjJVBi4-Y-GkzRVBWu502Z6vDHxePqGOidruE4vYGgz7HXeVbL~T9coKlLBzVSCIOBkA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":923,"name":"Technology","url":"https://www.academia.edu/Documents/in/Technology"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":222543,"name":"Biomed","url":"https://www.academia.edu/Documents/in/Biomed"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13476934"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13476934/Neurobiological_model_and_quality_of_life_in_discovering_personality_of_the_uremic_patient"><img alt="Research paper thumbnail of Neurobiological model and quality of life in discovering personality of the uremic patient" class="work-thumbnail" src="https://attachments.academia-assets.com/45295287/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13476934/Neurobiological_model_and_quality_of_life_in_discovering_personality_of_the_uremic_patient">Neurobiological model and quality of life in discovering personality of the uremic patient</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/CarmelaAloisi">Carmela Aloisi</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MicheleBuemi">Michele Buemi</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/AlessioSturiale">Alessio Sturiale</a></span></div><div class="wp-workCard_item"><span>Journal of nephrology</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The Short Form-36 Health Survey (SF-36) questionnaire is designed to measure the patient&#39;s fu...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The Short Form-36 Health Survey (SF-36) questionnaire is designed to measure the patient&#39;s functional capacity and well-being. It was created to reach a compromise between lengthy investigation methods and one dimensional, overly simple tools for measuring quality of life (QoL). In 1987, the psychiatrist Robert Cloninger proposed a psycho-biological model hinged upon three principal and independent dimensions of the human personality: novelty seeking (NS), harm avoidance (HA) and reward dependence (RD), linked with dopaminergic, serotoninergic and noradrenergic activity, respectively. According to Cloninger, each dimension is the expression of the integration of a hereditary condition, characterized by biologic substrates, in response to specific environmental stimuli. We furthermore searched for any interference between the SF-36 scores and plasmatic dopamine, serotonin and noradrenaline concentrations, in an attempt to identify eventual correlations between the condition of th...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7cde378f65c176ffc507c86158396c9f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":45295287,"asset_id":13476934,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/45295287/download_file?st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13476934"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13476934"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13476934; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13476934]").text(description); $(".js-view-count[data-work-id=13476934]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13476934; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13476934']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13476934, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7cde378f65c176ffc507c86158396c9f" } } $('.js-work-strip[data-work-id=13476934]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13476934,"title":"Neurobiological model and quality of life in discovering personality of the uremic patient","translated_title":"","metadata":{"abstract":"The Short Form-36 Health Survey (SF-36) questionnaire is designed to measure the patient\u0026#39;s functional capacity and well-being. It was created to reach a compromise between lengthy investigation methods and one dimensional, overly simple tools for measuring quality of life (QoL). In 1987, the psychiatrist Robert Cloninger proposed a psycho-biological model hinged upon three principal and independent dimensions of the human personality: novelty seeking (NS), harm avoidance (HA) and reward dependence (RD), linked with dopaminergic, serotoninergic and noradrenergic activity, respectively. According to Cloninger, each dimension is the expression of the integration of a hereditary condition, characterized by biologic substrates, in response to specific environmental stimuli. We furthermore searched for any interference between the SF-36 scores and plasmatic dopamine, serotonin and noradrenaline concentrations, in an attempt to identify eventual correlations between the condition of th...","publication_name":"Journal of nephrology"},"translated_abstract":"The Short Form-36 Health Survey (SF-36) questionnaire is designed to measure the patient\u0026#39;s functional capacity and well-being. It was created to reach a compromise between lengthy investigation methods and one dimensional, overly simple tools for measuring quality of life (QoL). In 1987, the psychiatrist Robert Cloninger proposed a psycho-biological model hinged upon three principal and independent dimensions of the human personality: novelty seeking (NS), harm avoidance (HA) and reward dependence (RD), linked with dopaminergic, serotoninergic and noradrenergic activity, respectively. 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href="https://www.academia.edu/13383387/Aquaporin_2_water_channels_in_spontaneously_hypertensive_rats">Aquaporin-2 water channels in spontaneously hypertensive rats</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MicheleBuemi">Michele Buemi</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://magaraibleo.academia.edu/GioacchinoCalapai">Gioacchino Calapai</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/FCorica">Francesco Corica</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/CarmelaAloisi">Carmela Aloisi</a></span></div><div class="wp-workCard_item"><span>American journal of hypertension</span><span>, 2004</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Vasopressin (AVP), an antidiuretic hormone, is known to induce hypervolemia and to regulate the r...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Vasopressin (AVP), an antidiuretic hormone, is known to induce hypervolemia and to regulate the renal expression of aquaporin-2 (AQP2) water channels, but it is not yet known whether the latter are involved in the pathogenesis of essential hypertension. The aim of the present study was therefore to make a comparative study of blood pressure (BP), urinary volume (UV), urinary osmolarity (uOsm), urinary AQP2 (uAQP2), and plasma AVP levels (PAVP) in male spontaneously hypertensive rats (SHR; n = 30) at 3, 7, and 12 weeks of age and in male Wistar-Kyoto rats (WKY, n = 30), also after the subcutaneous administration of OPC-31260 (OPC), a human AVP V(2) receptor antagonist. At 3 weeks, SHR had markedly higher uOsm and lower UV levels than WKY. At 7 weeks, SHR were hypertensive, showing increased uAQP2, PAVP, and uOsm levels and a decreased UV. At 12 weeks, no significant changes were observed in this condition. At 7 and 12 weeks of age, OPC-treated WKY rats showed significant reduction in...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="795eefa7b0a04b51b95d2ac22f7bd008" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":45401125,"asset_id":13383387,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/45401125/download_file?st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13383387"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13383387"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13383387; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13383387]").text(description); $(".js-view-count[data-work-id=13383387]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13383387; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13383387']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13383387, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "795eefa7b0a04b51b95d2ac22f7bd008" } } $('.js-work-strip[data-work-id=13383387]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13383387,"title":"Aquaporin-2 water channels in spontaneously hypertensive rats","translated_title":"","metadata":{"abstract":"Vasopressin (AVP), an antidiuretic hormone, is known to induce hypervolemia and to regulate the renal expression of aquaporin-2 (AQP2) water channels, but it is not yet known whether the latter are involved in the pathogenesis of essential hypertension. The aim of the present study was therefore to make a comparative study of blood pressure (BP), urinary volume (UV), urinary osmolarity (uOsm), urinary AQP2 (uAQP2), and plasma AVP levels (PAVP) in male spontaneously hypertensive rats (SHR; n = 30) at 3, 7, and 12 weeks of age and in male Wistar-Kyoto rats (WKY, n = 30), also after the subcutaneous administration of OPC-31260 (OPC), a human AVP V(2) receptor antagonist. At 3 weeks, SHR had markedly higher uOsm and lower UV levels than WKY. At 7 weeks, SHR were hypertensive, showing increased uAQP2, PAVP, and uOsm levels and a decreased UV. At 12 weeks, no significant changes were observed in this condition. 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wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13383374/RECOMBINANT_HUMAN_ERYTHROPOIETIN_STIMULATES_ANGIOGENESIS_AND_HEALING_OF_ISCHEMIC_SKIN_WOUNDS">RECOMBINANT HUMAN ERYTHROPOIETIN STIMULATES ANGIOGENESIS AND HEALING OF ISCHEMIC SKIN WOUNDS</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MicheleBuemi">Michele Buemi</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://magaraibleo.academia.edu/GioacchinoCalapai">Gioacchino Calapai</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/CarmelaAloisi">Carmela Aloisi</a></span></div><div class="wp-workCard_item"><span>Shock</span><span>, 2004</span></div><div 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Adequate tissue perfusion is particularly important in wound healing. We investigated the effects of recombinant human erythropoietin (rHuEPO) on wound healing in an ischemic skin wound model. Sixty-three Sprague-Dawley rats were used. Normal incisional wound and H-shaped double flaps were used as the wound models. Animals were treated with rHuEPO (400 IU/kg) or its vehicle. Rats were killed on different days (3, 5, and 10 days after skin injury) and the wounded skin tissues were used for immunohistochemistry and for analysis of vascular endothelial growth factor content and collagen content. Tissue transglutaminase immunostaining of histological specimens was used as a vascular marker to determine the level of microvessel density. The results showed a higher level of vascular endothelial growth factor protein and an increased microvessel density in ischemic wounds with rHuEPO treatment than the normal incisional wounds and ischemic control wounds. 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class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/16698270/Relationship_between_plasma_leptin_levels_and_the_tumor_necrosis_factor_alpha_system_in_obese_subjects">Relationship between plasma leptin levels and the tumor necrosis factor-alpha system in obese subjects</a></div><div class="wp-workCard_item"><span>International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity</span><span>, 1999</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To evaluate the relationship between plasma leptin and the tumor necrosis factor-alpha (TNFalpha)...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To evaluate the relationship between plasma leptin and the tumor necrosis factor-alpha (TNFalpha), TNF receptor p60 (TNF-R1) and TNF receptor p80 (TNF-R2) concentrations in obese subjects. Case-control study. Outpatient&#39;s Service for Prevention and Treatment of Obesity at the University Hospital. Body mass index (BMI), waist circumference, hip circumference, waist-to-hip ratio (WHR), fasting plasma glucose, fasting plasma insulin, homeostasis model assessment of insulin resistance (HOMA IR), plasma leptin, TNFalpha, TNF-R1 and TNF-R2 concentrations were evaluated in obese subjects (n = 42) and in age- and gender-matched, lean healthy controls (n = 16). In obese subjects, fasting plasma glucose and insulin, HOMA IR, plasma leptin, TNFalpha, TNF-R1 and TNF-R2 concentrations were significantly higher than in controls. Furthermore, females showed higher leptin, TNF-R1 and TNF-R2 plasma concentrations compared to males, in both control and obese subjects. In control subjects, plasma ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="72297ed99a4d07f228b0f9f7703ceb38" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42414158,"asset_id":16698270,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42414158/download_file?st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="16698270"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="16698270"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16698270; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16698270]").text(description); $(".js-view-count[data-work-id=16698270]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16698270; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='16698270']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 16698270, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "72297ed99a4d07f228b0f9f7703ceb38" } } $('.js-work-strip[data-work-id=16698270]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":16698270,"title":"Relationship between plasma leptin levels and the tumor necrosis factor-alpha system in obese subjects","translated_title":"","metadata":{"abstract":"To evaluate the relationship between plasma leptin and the tumor necrosis factor-alpha (TNFalpha), TNF receptor p60 (TNF-R1) and TNF receptor p80 (TNF-R2) concentrations in obese subjects. 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Fibers","translated_title":"","metadata":{"grobid_abstract":"Dramatic removal of potassium during hemodialysis sessions can induce changes in the electrical properties of nerve cells or muscle fibers, which may underlie neuromuscular symptoms referred by end-stage renal disease patients. The primary aim of our study was to investigate the effects of acetate-free biofiltration (AFB) on the amplitude of compound motor action potential (cMAP) obtained after stimulation of the ulnar nerve at the wrist. The secondary aim was to compare the effect of two different potassium removal modalities on cMAP amplitude and to analyze the effects on muscular force by specific dynamometric tests. Twenty-eight patients received dialysis for 4 h, 3 times per week, first with standard AFB with constant potassium (AFB) and then with AFB with a variable concentration of potassium in the dialysis bath (AFBK). The amplitude of cMAP was determined after ulnar nerve stimulation at the wrist at different time intervals: at the start of dialysis; at 15, 45, 90, and 120 min after beginning the session; and at the end of treatment. At the same time intervals, muscle force generation was determined using a","publication_date":{"day":null,"month":null,"year":2007,"errors":{}},"grobid_abstract_attachment_id":39125784},"translated_abstract":null,"internal_url":"https://www.academia.edu/16698268/Experimental_Therapies_in_Renal_Replacement_The_Effect_of_Two_Different_Potassium_Acetate_free_Biofiltration_Protocols_on_Striated_Muscle_Fibers","translated_internal_url":"","created_at":"2015-10-12T07:38:54.020-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36080295,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":39125784,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/39125784/thumbnails/1.jpg","file_name":"09e41509d0750325d8000000.pdf","download_url":"https://www.academia.edu/attachments/39125784/download_file?st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Experimental_Therapies_in_Renal_Replacem.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/39125784/09e41509d0750325d8000000-libre.pdf?1444660760=\u0026response-content-disposition=attachment%3B+filename%3DExperimental_Therapies_in_Renal_Replacem.pdf\u0026Expires=1732394066\u0026Signature=GYi92BuJ5nam8v~AFBCxBbd6cY4irLngefPTjSfRorqzXHW3~xPzM9zzkX0lEBePxpJMcj6I5D7xditfbRIXWO1m0kgiKNxpwdoIhY2wtKHAP0M50fPWYLvcdZEQZ-TIm0lFpGwRc230t1uVVdxQP30iO1v3IV06d0vvIrH8uUvqQadQJX7XyOCvU3hqYIwz0PBnxfn~2qPD2gZJsSuAie2iRnhjra2WBClMpeyOgxwzSBW15SPvD5KEb6cgAwQY88MQKV3nKG3TwduaCObhTs534dq-Ky1elCvCLdxRICvjJMOl5Cds0W-9i6A3aQNotws-87niwwdmAOCAfufaBw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Experimental_Therapies_in_Renal_Replacement_The_Effect_of_Two_Different_Potassium_Acetate_free_Biofiltration_Protocols_on_Striated_Muscle_Fibers","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":36080295,"first_name":"Michele","middle_initials":null,"last_name":"Buemi","page_name":"MicheleBuemi","domain_name":"independent","created_at":"2015-10-12T07:37:32.970-07:00","display_name":"Michele Buemi","url":"https://independent.academia.edu/MicheleBuemi"},"attachments":[{"id":39125784,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/39125784/thumbnails/1.jpg","file_name":"09e41509d0750325d8000000.pdf","download_url":"https://www.academia.edu/attachments/39125784/download_file?st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Experimental_Therapies_in_Renal_Replacem.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/39125784/09e41509d0750325d8000000-libre.pdf?1444660760=\u0026response-content-disposition=attachment%3B+filename%3DExperimental_Therapies_in_Renal_Replacem.pdf\u0026Expires=1732394066\u0026Signature=GYi92BuJ5nam8v~AFBCxBbd6cY4irLngefPTjSfRorqzXHW3~xPzM9zzkX0lEBePxpJMcj6I5D7xditfbRIXWO1m0kgiKNxpwdoIhY2wtKHAP0M50fPWYLvcdZEQZ-TIm0lFpGwRc230t1uVVdxQP30iO1v3IV06d0vvIrH8uUvqQadQJX7XyOCvU3hqYIwz0PBnxfn~2qPD2gZJsSuAie2iRnhjra2WBClMpeyOgxwzSBW15SPvD5KEb6cgAwQY88MQKV3nKG3TwduaCObhTs534dq-Ky1elCvCLdxRICvjJMOl5Cds0W-9i6A3aQNotws-87niwwdmAOCAfufaBw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":39000,"name":"Electrocardiography","url":"https://www.academia.edu/Documents/in/Electrocardiography"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":160656,"name":"Potassium","url":"https://www.academia.edu/Documents/in/Potassium"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":295155,"name":"Middle Aged","url":"https://www.academia.edu/Documents/in/Middle_Aged"},{"id":373249,"name":"Electrolytes","url":"https://www.academia.edu/Documents/in/Electrolytes"},{"id":955727,"name":"Action Potentials","url":"https://www.academia.edu/Documents/in/Action_Potentials"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13613377"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13613377/Effect_of_a_Prostacyclin_Analogue_Iloprost_on_Urinary_Aquaporin_2_Excretion_in_Humans"><img alt="Research paper thumbnail of Effect of a Prostacyclin Analogue, Iloprost, on Urinary Aquaporin-2 Excretion in Humans" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13613377/Effect_of_a_Prostacyclin_Analogue_Iloprost_on_Urinary_Aquaporin_2_Excretion_in_Humans">Effect of a Prostacyclin Analogue, Iloprost, on Urinary Aquaporin-2 Excretion in Humans</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/AlessioSturiale">Alessio Sturiale</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MicheleBuemi">Michele Buemi</a></span></div><div class="wp-workCard_item"><span>Nephron</span><span>, 2002</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The regulation of aquaporin-2 (AQP2) water channel excretion in the collecting duct depends mainl...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The regulation of aquaporin-2 (AQP2) water channel excretion in the collecting duct depends mainly on the action of vasopressin (AVP). Recently, however, other regulatory factors have been identified: atrial natriuretic factor, oxytocin and prostaglandins. In healthy volunteers (5 males, 5 females; mean age 23 +/- 3 years) we therefore evaluated the effect of a stable analogue of prostacyclin-2 (PGI(2)), iloprost, on renal function and on the urinary excretion of AQP2 (U-AQP2). After 6 h of iloprost infusion, U-AQP2 increased from 0.8 +/- 0.15 to 1.8 +/- 0.2 pmol/mg creatinine (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001), while the urinary flow rate increased from 1.4 +/- 0.2 to 1.8 +/- 4 (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.01). No significant change was found in the AVP serum concentration, with a basal value of 3.17 +/- 0.12 vs. 3.15 +/- 0.12 pg/ml after 6 h of prostacyclin infusion. All the values returned to pre-study levels after a recovery period of 6 h. In conclusion, the PGI(2) analogue, iloprost, can induce U-AQP2 excretion independent of AVP.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13613377"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13613377"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13613377; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13613377]").text(description); $(".js-view-count[data-work-id=13613377]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13613377; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13613377']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13613377, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=13613377]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13613377,"title":"Effect of a Prostacyclin Analogue, Iloprost, on Urinary Aquaporin-2 Excretion in Humans","translated_title":"","metadata":{"abstract":"The regulation of aquaporin-2 (AQP2) water channel excretion in the collecting duct depends mainly on the action of vasopressin (AVP). Recently, however, other regulatory factors have been identified: atrial natriuretic factor, oxytocin and prostaglandins. In healthy volunteers (5 males, 5 females; mean age 23 +/- 3 years) we therefore evaluated the effect of a stable analogue of prostacyclin-2 (PGI(2)), iloprost, on renal function and on the urinary excretion of AQP2 (U-AQP2). After 6 h of iloprost infusion, U-AQP2 increased from 0.8 +/- 0.15 to 1.8 +/- 0.2 pmol/mg creatinine (p \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001), while the urinary flow rate increased from 1.4 +/- 0.2 to 1.8 +/- 4 (p \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.01). No significant change was found in the AVP serum concentration, with a basal value of 3.17 +/- 0.12 vs. 3.15 +/- 0.12 pg/ml after 6 h of prostacyclin infusion. All the values returned to pre-study levels after a recovery period of 6 h. In conclusion, the PGI(2) analogue, iloprost, can induce U-AQP2 excretion independent of AVP.","publication_date":{"day":null,"month":null,"year":2002,"errors":{}},"publication_name":"Nephron"},"translated_abstract":"The regulation of aquaporin-2 (AQP2) water channel excretion in the collecting duct depends mainly on the action of vasopressin (AVP). Recently, however, other regulatory factors have been identified: atrial natriuretic factor, oxytocin and prostaglandins. In healthy volunteers (5 males, 5 females; mean age 23 +/- 3 years) we therefore evaluated the effect of a stable analogue of prostacyclin-2 (PGI(2)), iloprost, on renal function and on the urinary excretion of AQP2 (U-AQP2). After 6 h of iloprost infusion, U-AQP2 increased from 0.8 +/- 0.15 to 1.8 +/- 0.2 pmol/mg creatinine (p \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001), while the urinary flow rate increased from 1.4 +/- 0.2 to 1.8 +/- 4 (p \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.01). No significant change was found in the AVP serum concentration, with a basal value of 3.17 +/- 0.12 vs. 3.15 +/- 0.12 pg/ml after 6 h of prostacyclin infusion. All the values returned to pre-study levels after a recovery period of 6 h. In conclusion, the PGI(2) analogue, iloprost, can induce U-AQP2 excretion independent of AVP.","internal_url":"https://www.academia.edu/13613377/Effect_of_a_Prostacyclin_Analogue_Iloprost_on_Urinary_Aquaporin_2_Excretion_in_Humans","translated_internal_url":"","created_at":"2015-07-04T04:49:38.023-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32784653,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":2214349,"work_id":13613377,"tagging_user_id":32784653,"tagged_user_id":32694920,"co_author_invite_id":null,"email":"c***i@unime.it","display_order":0,"name":"Carmela Aloisi","title":"Effect of a Prostacyclin Analogue, Iloprost, on Urinary Aquaporin-2 Excretion in Humans"},{"id":2214400,"work_id":13613377,"tagging_user_id":32784653,"tagged_user_id":36080295,"co_author_invite_id":497662,"email":"b***m@unime.it","display_order":4194304,"name":"Michele Buemi","title":"Effect of a Prostacyclin Analogue, Iloprost, on Urinary Aquaporin-2 Excretion in Humans"}],"downloadable_attachments":[],"slug":"Effect_of_a_Prostacyclin_Analogue_Iloprost_on_Urinary_Aquaporin_2_Excretion_in_Humans","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":32784653,"first_name":"Alessio","middle_initials":null,"last_name":"Sturiale","page_name":"AlessioSturiale","domain_name":"independent","created_at":"2015-07-04T04:48:10.611-07:00","display_name":"Alessio Sturiale","url":"https://independent.academia.edu/AlessioSturiale"},"attachments":[],"research_interests":[{"id":53735,"name":"Oxytocin","url":"https://www.academia.edu/Documents/in/Oxytocin"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":66880,"name":"Aquaporins (AQP)","url":"https://www.academia.edu/Documents/in/Aquaporins_AQP_"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology"},{"id":227354,"name":"Renal Function","url":"https://www.academia.edu/Documents/in/Renal_Function"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":325753,"name":"Water Channel","url":"https://www.academia.edu/Documents/in/Water_Channel"},{"id":382075,"name":"Adult","url":"https://www.academia.edu/Documents/in/Adult"},{"id":443927,"name":"Aquaporin","url":"https://www.academia.edu/Documents/in/Aquaporin"},{"id":898062,"name":"Flow Rate","url":"https://www.academia.edu/Documents/in/Flow_Rate"},{"id":1438730,"name":"Creatinine","url":"https://www.academia.edu/Documents/in/Creatinine"},{"id":1626168,"name":"Prostaglandin E2","url":"https://www.academia.edu/Documents/in/Prostaglandin_E2"},{"id":2015813,"name":"Atrial Natriuretic Factor","url":"https://www.academia.edu/Documents/in/Atrial_Natriuretic_Factor"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13476933"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13476933/Reduced_bcl_2_concentrations_in_hypertensive_patients_after_lisinopril_or_nifedipine_administration"><img alt="Research paper thumbnail of Reduced bcl-2 concentrations in hypertensive patients after lisinopril or nifedipine administration" class="work-thumbnail" src="https://attachments.academia-assets.com/45295326/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13476933/Reduced_bcl_2_concentrations_in_hypertensive_patients_after_lisinopril_or_nifedipine_administration">Reduced bcl-2 concentrations in hypertensive patients after lisinopril or nifedipine administration</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MicheleBuemi">Michele Buemi</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/CarmelaAloisi">Carmela Aloisi</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/FCorica">Francesco Corica</a></span></div><div class="wp-workCard_item"><span>American Journal of Hypertension</span><span>, 1999</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="afbf87fd2b4efd859a978d779ed24adc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":45295326,"asset_id":13476933,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/45295326/download_file?st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13476933"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13476933"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13476933; 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$a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="16698264"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/16698264/Intravenous_recombinant_erythropoietin_does_not_lead_to_an_increase_in_cerebrospinal_fluid_erythropoietin_concentration"><img alt="Research paper thumbnail of Intravenous recombinant erythropoietin does not lead to an increase in cerebrospinal fluid erythropoietin concentration" class="work-thumbnail" src="https://attachments.academia-assets.com/42414151/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" 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Patients undergoing hemodialysis show a reduced number and an impaired function of endothelial progenitor cells (EPCs), which in physiological conditions contribute to repair the vascular damage. In patients with ESRD, massive oxidative genome damage has been demonstrated but the role of HD in causing it is still a controversial issue. The aim of our study was to analyze the effects of a single HD session on the number of cells marked with CD34 (including sub-type cells known to be EPCs); we then evaluated the genomic damage in these cells using COMET assay. We quantified CD34(+) cells in blood samples in 30 patients in hemodiafiltration treatment for 3.5 to 4 hours 3 times/week and in 30 healthy volunteers. 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In HD patients, blood samples were drawn at different time intervals: start of dialysis (T(0)), at the end of the treatment (T(end)) and 24 hours afterwards in the interdialy...","publication_name":"Journal of nephrology"},"translated_abstract":"End stage renal disease (ESRD) is associated with a high incidence of cardiovascular disease and cancer. Patients undergoing hemodialysis show a reduced number and an impaired function of endothelial progenitor cells (EPCs), which in physiological conditions contribute to repair the vascular damage. In patients with ESRD, massive oxidative genome damage has been demonstrated but the role of HD in causing it is still a controversial issue. The aim of our study was to analyze the effects of a single HD session on the number of cells marked with CD34 (including sub-type cells known to be EPCs); we then evaluated the genomic damage in these cells using COMET assay. 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In HD patients, blood samples were drawn at different time intervals: start of dialysis (T(0)), at the end of the treatment (T(end)) and 24 hours afterwards in the interdialy...","internal_url":"https://www.academia.edu/16698258/Genomic_damage_in_endothelial_progenitor_cells_from_uremic_patients_in_hemodialysis","translated_internal_url":"","created_at":"2015-10-12T07:38:51.858-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36080295,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":39125781,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/39125781/thumbnails/1.jpg","file_name":"0fcfd509cdfa8b8b8a000000.pdf","download_url":"https://www.academia.edu/attachments/39125781/download_file?st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Genomic_damage_in_endothelial_progenitor.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/39125781/0fcfd509cdfa8b8b8a000000-libre.pdf?1444660805=\u0026response-content-disposition=attachment%3B+filename%3DGenomic_damage_in_endothelial_progenitor.pdf\u0026Expires=1732394066\u0026Signature=UVE2HmDUmv7THc9CRcYv~Z5nACJtjm0LrfcA1rT7qtrpwRjSdJYHSNjI6TxZzsjsRtSgTdwazJ9w6ej7MEMD5oZF6nb5gmBiLNMMtvZH~h2GdmttDlGVgeSogx-lRiyZA2i1OlPICbZlB5CxpoTtwkryvxrvjeGffxBsuR-dL90xLVi2c~57mYQvqBxk21gD1RIDHEutdbzXSMysp4yPXhC3EyuT-WUI4Zy-rbRO5NpmJFrgUdKyWBUV8zViYDQviXO4H9CUsrb0JcNLA7MBhklCKKtEx8f3qlYZHQ0hQqz6MXazH0jpCU~7XF6l2wYWrzCXOHfjrMqZ3Eja8Wb03w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Genomic_damage_in_endothelial_progenitor_cells_from_uremic_patients_in_hemodialysis","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":36080295,"first_name":"Michele","middle_initials":null,"last_name":"Buemi","page_name":"MicheleBuemi","domain_name":"independent","created_at":"2015-10-12T07:37:32.970-07:00","display_name":"Michele Buemi","url":"https://independent.academia.edu/MicheleBuemi"},"attachments":[{"id":39125781,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/39125781/thumbnails/1.jpg","file_name":"0fcfd509cdfa8b8b8a000000.pdf","download_url":"https://www.academia.edu/attachments/39125781/download_file?st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Genomic_damage_in_endothelial_progenitor.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/39125781/0fcfd509cdfa8b8b8a000000-libre.pdf?1444660805=\u0026response-content-disposition=attachment%3B+filename%3DGenomic_damage_in_endothelial_progenitor.pdf\u0026Expires=1732394066\u0026Signature=UVE2HmDUmv7THc9CRcYv~Z5nACJtjm0LrfcA1rT7qtrpwRjSdJYHSNjI6TxZzsjsRtSgTdwazJ9w6ej7MEMD5oZF6nb5gmBiLNMMtvZH~h2GdmttDlGVgeSogx-lRiyZA2i1OlPICbZlB5CxpoTtwkryvxrvjeGffxBsuR-dL90xLVi2c~57mYQvqBxk21gD1RIDHEutdbzXSMysp4yPXhC3EyuT-WUI4Zy-rbRO5NpmJFrgUdKyWBUV8zViYDQviXO4H9CUsrb0JcNLA7MBhklCKKtEx8f3qlYZHQ0hQqz6MXazH0jpCU~7XF6l2wYWrzCXOHfjrMqZ3Eja8Wb03w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":622,"name":"Nephrology","url":"https://www.academia.edu/Documents/in/Nephrology"},{"id":3642,"name":"Stem Cells","url":"https://www.academia.edu/Documents/in/Stem_Cells"},{"id":23066,"name":"DNA damage","url":"https://www.academia.edu/Documents/in/DNA_damage"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":71510,"name":"Endothelial Cells","url":"https://www.academia.edu/Documents/in/Endothelial_Cells"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":101212,"name":"Hemodialysis","url":"https://www.academia.edu/Documents/in/Hemodialysis"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":279382,"name":"Comet Assay","url":"https://www.academia.edu/Documents/in/Comet_Assay"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":295155,"name":"Middle Aged","url":"https://www.academia.edu/Documents/in/Middle_Aged"},{"id":382075,"name":"Adult","url":"https://www.academia.edu/Documents/in/Adult"},{"id":956026,"name":"Somatic Cell Count","url":"https://www.academia.edu/Documents/in/Somatic_Cell_Count"},{"id":1611680,"name":"Renal Dialysis","url":"https://www.academia.edu/Documents/in/Renal_Dialysis"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="16698257"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/16698257/Chromosomal_damage_and_atherosclerosis_A_protective_effect_from_simvastatin"><img alt="Research paper thumbnail of Chromosomal damage and atherosclerosis. A protective effect from simvastatin" class="work-thumbnail" src="https://attachments.academia-assets.com/42414180/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/16698257/Chromosomal_damage_and_atherosclerosis_A_protective_effect_from_simvastatin">Chromosomal damage and atherosclerosis. A protective effect from simvastatin</a></div><div class="wp-workCard_item"><span>European Journal of Pharmacology</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In uremic patients, the frequency of sister chromatid exchanges appears markedly higher than in t...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In uremic patients, the frequency of sister chromatid exchanges appears markedly higher than in the general population. Statins are well known for their pleiotropic effects, which are independent of any reduction in cholesterol circulating levels. The aim of the present study was to determine the effects of exposure to escalating doses of simvastatin on the sister chromatid exchange rate in</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4bd557752843729e92d428f417d1f564" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42414180,"asset_id":16698257,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42414180/download_file?st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="16698257"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="16698257"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16698257; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16698257]").text(description); $(".js-view-count[data-work-id=16698257]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16698257; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='16698257']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 16698257, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4bd557752843729e92d428f417d1f564" } } $('.js-work-strip[data-work-id=16698257]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":16698257,"title":"Chromosomal damage and atherosclerosis. A protective effect from simvastatin","translated_title":"","metadata":{"abstract":"In uremic patients, the frequency of sister chromatid exchanges appears markedly higher than in the general population. Statins are well known for their pleiotropic effects, which are independent of any reduction in cholesterol circulating levels. The aim of the present study was to determine the effects of exposure to escalating doses of simvastatin on the sister chromatid exchange rate in","publication_date":{"day":null,"month":null,"year":2006,"errors":{}},"publication_name":"European Journal of Pharmacology"},"translated_abstract":"In uremic patients, the frequency of sister chromatid exchanges appears markedly higher than in the general population. Statins are well known for their pleiotropic effects, which are independent of any reduction in cholesterol circulating levels. The aim of the present study was to determine the effects of exposure to escalating doses of simvastatin on the sister chromatid exchange rate in","internal_url":"https://www.academia.edu/16698257/Chromosomal_damage_and_atherosclerosis_A_protective_effect_from_simvastatin","translated_internal_url":"","created_at":"2015-10-12T07:38:51.340-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36080295,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":42414180,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42414180/thumbnails/1.jpg","file_name":"j.ejphar.2006.01.003.pdf20160208-1144-1jsqlvo","download_url":"https://www.academia.edu/attachments/42414180/download_file?st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Chromosomal_damage_and_atherosclerosis_A.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42414180/j.ejphar.2006.01.003-libre.pdf20160208-1144-1jsqlvo?1454976471=\u0026response-content-disposition=attachment%3B+filename%3DChromosomal_damage_and_atherosclerosis_A.pdf\u0026Expires=1732416356\u0026Signature=YWEUaHZmLwLxGfIltGi8waVByInEI3KZWpzE6-pMCpPTHR7ggyDO1cO0iL9kFzBQFhu7NhnRUZWWF2cNNfXV7dQii4auuWhlHvslBj24pMFktmVaQXqRYCRRap9fU64wIHISocy07RGP28Lcj6gv63V8aTFeuPwxbfHqHk~2tuu0ECccSBtGTuGfBpwIKJHiJS2kcilVqFwD0sBnTyfsDmRO0c~~jGKxlNPH7nthzF18lEJdeV7CVKuBoIeW4WfW6V8yd~GQMl6dn76Ll6aBk0~M4Wst6ZzRUFRC-qKOMBmTA-f6dtIO6YHF7S2T5t-PiNCx4LMSWmS4mGrb8AN99g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Chromosomal_damage_and_atherosclerosis_A_protective_effect_from_simvastatin","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":36080295,"first_name":"Michele","middle_initials":null,"last_name":"Buemi","page_name":"MicheleBuemi","domain_name":"independent","created_at":"2015-10-12T07:37:32.970-07:00","display_name":"Michele Buemi","url":"https://independent.academia.edu/MicheleBuemi"},"attachments":[{"id":42414180,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42414180/thumbnails/1.jpg","file_name":"j.ejphar.2006.01.003.pdf20160208-1144-1jsqlvo","download_url":"https://www.academia.edu/attachments/42414180/download_file?st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Chromosomal_damage_and_atherosclerosis_A.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42414180/j.ejphar.2006.01.003-libre.pdf20160208-1144-1jsqlvo?1454976471=\u0026response-content-disposition=attachment%3B+filename%3DChromosomal_damage_and_atherosclerosis_A.pdf\u0026Expires=1732416356\u0026Signature=YWEUaHZmLwLxGfIltGi8waVByInEI3KZWpzE6-pMCpPTHR7ggyDO1cO0iL9kFzBQFhu7NhnRUZWWF2cNNfXV7dQii4auuWhlHvslBj24pMFktmVaQXqRYCRRap9fU64wIHISocy07RGP28Lcj6gv63V8aTFeuPwxbfHqHk~2tuu0ECccSBtGTuGfBpwIKJHiJS2kcilVqFwD0sBnTyfsDmRO0c~~jGKxlNPH7nthzF18lEJdeV7CVKuBoIeW4WfW6V8yd~GQMl6dn76Ll6aBk0~M4Wst6ZzRUFRC-qKOMBmTA-f6dtIO6YHF7S2T5t-PiNCx4LMSWmS4mGrb8AN99g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":8015,"name":"Atherosclerosis","url":"https://www.academia.edu/Documents/in/Atherosclerosis"},{"id":48458,"name":"High Frequency","url":"https://www.academia.edu/Documents/in/High_Frequency"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":85188,"name":"End Stage Renal Disease","url":"https://www.academia.edu/Documents/in/End_Stage_Renal_Disease"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European"},{"id":295155,"name":"Middle Aged","url":"https://www.academia.edu/Documents/in/Middle_Aged"},{"id":868560,"name":"Lymphocytes","url":"https://www.academia.edu/Documents/in/Lymphocytes"},{"id":1106287,"name":"Chronic Kidney Failure","url":"https://www.academia.edu/Documents/in/Chronic_Kidney_Failure"},{"id":1168109,"name":"Mitotic Index","url":"https://www.academia.edu/Documents/in/Mitotic_Index"},{"id":1315270,"name":"Simvastatin","url":"https://www.academia.edu/Documents/in/Simvastatin"},{"id":1423006,"name":"General Population","url":"https://www.academia.edu/Documents/in/General_Population"}],"urls":[{"id":5938399,"url":"http://www.sciencedirect.com/science/article/pii/S0014299906000112"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="16698254"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/16698254/Dialysis_related_genotoxicity_sister_chromatid_exchanges_and_DNA_lesions_in_T_and_B_lymphocytes_of_uremic_patients_Genomic_damage_in_patients_on_hemodiafiltration"><img alt="Research paper thumbnail of Dialysis-related genotoxicity: sister chromatid exchanges and DNA lesions in T and B lymphocytes of uremic patients. Genomic damage in patients on hemodiafiltration" class="work-thumbnail" src="https://attachments.academia-assets.com/39125778/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/16698254/Dialysis_related_genotoxicity_sister_chromatid_exchanges_and_DNA_lesions_in_T_and_B_lymphocytes_of_uremic_patients_Genomic_damage_in_patients_on_hemodiafiltration">Dialysis-related genotoxicity: sister chromatid exchanges and DNA lesions in T and B lymphocytes of uremic patients. Genomic damage in patients on hemodiafiltration</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8a606d49a3f1b70bfe812e7e060db405" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39125778,"asset_id":16698254,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39125778/download_file?st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="16698254"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="16698254"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16698254; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16698254]").text(description); $(".js-view-count[data-work-id=16698254]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16698254; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='16698254']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 16698254, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8a606d49a3f1b70bfe812e7e060db405" } } $('.js-work-strip[data-work-id=16698254]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":16698254,"title":"Dialysis-related genotoxicity: sister chromatid exchanges and DNA lesions in T and B lymphocytes of uremic patients. Genomic damage in patients on hemodiafiltration","translated_title":"","metadata":{"grobid_abstract":"Background/Aims: Patients with chronic renal failure show the presence of massive oxidative genome damage but the role played by dialysis is still a controversial issue. The aim of our study was to verify the genomic damage in B-and T-lymphocyte subpopulations of uremic patients after a single hemodiafiltration session. Methods: We enrolled 30 patients on maintenance acetate-free biofiltration and 25 agematched healthy volunteers and studied chromosomal alterations. Results: Our data show that the basal levels of DNA damage, the number of sister chromatid exchanges and basal high-frequency cells levels are significantly higher in patients on hemodiafiltration than in controls and in T lymphocytes than in B cells. Conclusions: These findings suggest that hemodialytic treatment could represent a potential source of damage, maybe through the oxidative action of the extracorporeal circuit components, which might explain the well-known T-specific immunodeficiency correlated with uremia.","publication_date":{"day":null,"month":null,"year":2006,"errors":{}},"grobid_abstract_attachment_id":39125778},"translated_abstract":null,"internal_url":"https://www.academia.edu/16698254/Dialysis_related_genotoxicity_sister_chromatid_exchanges_and_DNA_lesions_in_T_and_B_lymphocytes_of_uremic_patients_Genomic_damage_in_patients_on_hemodiafiltration","translated_internal_url":"","created_at":"2015-10-12T07:38:50.838-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36080295,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":39125778,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/39125778/thumbnails/1.jpg","file_name":"09e41509d0a1e4c317000000.pdf","download_url":"https://www.academia.edu/attachments/39125778/download_file?st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Dialysis_related_genotoxicity_sister_chr.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/39125778/09e41509d0a1e4c317000000-libre.pdf?1444660762=\u0026response-content-disposition=attachment%3B+filename%3DDialysis_related_genotoxicity_sister_chr.pdf\u0026Expires=1732394066\u0026Signature=btyrTmrkNffbCjvnGcX4R2yN9MukKTC5Ice9BzlHCH469I2u8aNwyXa31z9QO11jojULJUOXYK-ihKm4dN-nk9GR57DKO0sMeTT-gvrUDeOuDBhWFgV4GVPe96dOryGn7FbtZjcDJ40w8GHdXvZ4MHXMc32e5UVme8fJ8kb87-z-WtGmZglePElkX6o-6yj0nf3ERKtPi4cuSdaBIu1YMrhRgsR6H65d~TRPBnQOv537p31VzfP7FV0g60hwYiCf~mMi~sJBWYadeg~XRe5B6C6BrMfwrISbrSqkfrKiBqHgGQilDyMiPs~9ERxPddDiXKY0jWqP6ODO1omUrnvzRg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Dialysis_related_genotoxicity_sister_chromatid_exchanges_and_DNA_lesions_in_T_and_B_lymphocytes_of_uremic_patients_Genomic_damage_in_patients_on_hemodiafiltration","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":36080295,"first_name":"Michele","middle_initials":null,"last_name":"Buemi","page_name":"MicheleBuemi","domain_name":"independent","created_at":"2015-10-12T07:37:32.970-07:00","display_name":"Michele Buemi","url":"https://independent.academia.edu/MicheleBuemi"},"attachments":[{"id":39125778,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/39125778/thumbnails/1.jpg","file_name":"09e41509d0a1e4c317000000.pdf","download_url":"https://www.academia.edu/attachments/39125778/download_file?st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Dialysis_related_genotoxicity_sister_chr.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/39125778/09e41509d0a1e4c317000000-libre.pdf?1444660762=\u0026response-content-disposition=attachment%3B+filename%3DDialysis_related_genotoxicity_sister_chr.pdf\u0026Expires=1732394066\u0026Signature=btyrTmrkNffbCjvnGcX4R2yN9MukKTC5Ice9BzlHCH469I2u8aNwyXa31z9QO11jojULJUOXYK-ihKm4dN-nk9GR57DKO0sMeTT-gvrUDeOuDBhWFgV4GVPe96dOryGn7FbtZjcDJ40w8GHdXvZ4MHXMc32e5UVme8fJ8kb87-z-WtGmZglePElkX6o-6yj0nf3ERKtPi4cuSdaBIu1YMrhRgsR6H65d~TRPBnQOv537p31VzfP7FV0g60hwYiCf~mMi~sJBWYadeg~XRe5B6C6BrMfwrISbrSqkfrKiBqHgGQilDyMiPs~9ERxPddDiXKY0jWqP6ODO1omUrnvzRg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":23066,"name":"DNA damage","url":"https://www.academia.edu/Documents/in/DNA_damage"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":279382,"name":"Comet Assay","url":"https://www.academia.edu/Documents/in/Comet_Assay"},{"id":280237,"name":"T lymphocytes","url":"https://www.academia.edu/Documents/in/T_lymphocytes"},{"id":295155,"name":"Middle Aged","url":"https://www.academia.edu/Documents/in/Middle_Aged"},{"id":678853,"name":"B Lymphocytes","url":"https://www.academia.edu/Documents/in/B_Lymphocytes"},{"id":1106287,"name":"Chronic Kidney Failure","url":"https://www.academia.edu/Documents/in/Chronic_Kidney_Failure"}],"urls":[{"id":5938398,"url":"http://content.karger.com/ProdukteDB/produkte.asp?doi=10.1159/000097080"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13476932"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13476932/C010_The_serum_of_patients_treated_with_fluvastatin_induces_apoptosis_in_human_monocitoid_cells"><img alt="Research paper thumbnail of C010 The serum of patients treated with fluvastatin induces apoptosis in human monocitoid cells" class="work-thumbnail" src="https://attachments.academia-assets.com/45295297/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13476932/C010_The_serum_of_patients_treated_with_fluvastatin_induces_apoptosis_in_human_monocitoid_cells">C010 The serum of patients treated with fluvastatin induces apoptosis in human monocitoid cells</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MicheleBuemi">Michele Buemi</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/CarmelaAloisi">Carmela Aloisi</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/FCorica">Francesco Corica</a></span></div><div class="wp-workCard_item"><span>American Journal of Hypertension</span><span>, 1998</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7897b8aae675b9d26aa4994f8572f4e1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":45295297,"asset_id":13476932,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/45295297/download_file?st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&st=MTczMjQxMjc1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13476932"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13476932"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13476932; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="16698251"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/16698251/Vitamin_D_Receptor_Polymorphism_in_Chronic_Kidney_Disease_Patients_With_Complicated_Cardiovascular_Disease"><img alt="Research paper thumbnail of Vitamin D Receptor Polymorphism in Chronic Kidney Disease Patients With Complicated Cardiovascular Disease" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/16698251/Vitamin_D_Receptor_Polymorphism_in_Chronic_Kidney_Disease_Patients_With_Complicated_Cardiovascular_Disease">Vitamin D Receptor Polymorphism in Chronic Kidney Disease Patients With Complicated Cardiovascular Disease</a></div><div class="wp-workCard_item"><span>Journal of Renal Nutrition</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Several studies indicate a relationship between vitamin D and cardiovascular disease. Pleiotropic...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Several studies indicate a relationship between vitamin D and cardiovascular disease. Pleiotropic actions of vitamin D and its analogs are mediated by vitamin D receptor (VDR). VDRs have been identified in almost all tissues, including vascular smooth muscle cells, cardiomyocytes, and endothelial cells. The FokI and BsmI polymorphisms of the VDR gene are regarded as strong markers of disturbed vitamin D signaling pathway. Studies investigating the relationship between VDR genotypes and left ventricular hypertrophy revealed a highly significant association with the BsmI Bb heterozygous genotype. There are conflicting data on the action of vitamin D in left ventricular hypertrophy. Experimental as well as observational studies and small clinical trials have suggested that vitamin D administration may favorably influence left ventricular hypertrophy, whereas large randomized clinical trials have shown negative results. However, a beneficial effect on the left atrial volume index and the duration of hospitalization were observed in patients treated with vitamin D analogs. Larger clinical trials with robust clinical end points are needed to confirm that vitamin D is effective in preventing cardiovascular disease in chronic kidney disease patients and in general population.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="16698251"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="16698251"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16698251; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16698251]").text(description); $(".js-view-count[data-work-id=16698251]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16698251; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='16698251']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 16698251, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=16698251]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":16698251,"title":"Vitamin D Receptor Polymorphism in Chronic Kidney Disease Patients With Complicated Cardiovascular Disease","translated_title":"","metadata":{"abstract":"Several studies indicate a relationship between vitamin D and cardiovascular disease. Pleiotropic actions of vitamin D and its analogs are mediated by vitamin D receptor (VDR). VDRs have been identified in almost all tissues, including vascular smooth muscle cells, cardiomyocytes, and endothelial cells. The FokI and BsmI polymorphisms of the VDR gene are regarded as strong markers of disturbed vitamin D signaling pathway. Studies investigating the relationship between VDR genotypes and left ventricular hypertrophy revealed a highly significant association with the BsmI Bb heterozygous genotype. There are conflicting data on the action of vitamin D in left ventricular hypertrophy. Experimental as well as observational studies and small clinical trials have suggested that vitamin D administration may favorably influence left ventricular hypertrophy, whereas large randomized clinical trials have shown negative results. However, a beneficial effect on the left atrial volume index and the duration of hospitalization were observed in patients treated with vitamin D analogs. Larger clinical trials with robust clinical end points are needed to confirm that vitamin D is effective in preventing cardiovascular disease in chronic kidney disease patients and in general population.","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Journal of Renal Nutrition"},"translated_abstract":"Several studies indicate a relationship between vitamin D and cardiovascular disease. Pleiotropic actions of vitamin D and its analogs are mediated by vitamin D receptor (VDR). VDRs have been identified in almost all tissues, including vascular smooth muscle cells, cardiomyocytes, and endothelial cells. The FokI and BsmI polymorphisms of the VDR gene are regarded as strong markers of disturbed vitamin D signaling pathway. Studies investigating the relationship between VDR genotypes and left ventricular hypertrophy revealed a highly significant association with the BsmI Bb heterozygous genotype. 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Larger clinical trials with robust clinical end points are needed to confirm that vitamin D is effective in preventing cardiovascular disease in chronic kidney disease patients and in general population.","internal_url":"https://www.academia.edu/16698251/Vitamin_D_Receptor_Polymorphism_in_Chronic_Kidney_Disease_Patients_With_Complicated_Cardiovascular_Disease","translated_internal_url":"","created_at":"2015-10-12T07:38:50.199-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36080295,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Vitamin_D_Receptor_Polymorphism_in_Chronic_Kidney_Disease_Patients_With_Complicated_Cardiovascular_Disease","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":36080295,"first_name":"Michele","middle_initials":null,"last_name":"Buemi","page_name":"MicheleBuemi","domain_name":"independent","created_at":"2015-10-12T07:37:32.970-07:00","display_name":"Michele Buemi","url":"https://independent.academia.edu/MicheleBuemi"},"attachments":[],"research_interests":[{"id":591,"name":"Nutrition and Dietetics","url":"https://www.academia.edu/Documents/in/Nutrition_and_Dietetics"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":408710,"name":"Renal Nutrition","url":"https://www.academia.edu/Documents/in/Renal_Nutrition"}],"urls":[]}, dispatcherData: dispatcherData }); 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