Innovative Avidite Sequencing Technology

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class="bold-shift" data-text="Who We Are">Who We Are</span></a><a href="/about/team" class="header-link"><span class="bold-shift" data-text="Leadership">Leadership</span></a><a href="/about/testimonials" class="header-link"><span class="bold-shift" data-text="Elemental Insights">Elemental Insights</span></a><a href="/legal/terms" class="header-link"><span class="bold-shift" data-text="Legal">Legal</span></a></div><div class="header-feature"><picture class="header-feature__photo"><source srcset="https://www.elementbiosciences.com/uploads/header/features/_headerFeaturePhotoWebp/7895292/header-company-feature.webp" type="image/webp"><img src="https://www.elementbiosciences.com/uploads/header/features/_headerFeaturePhoto/header-company-feature.png" width="500" height="500" alt="Three Element employees wearing lab coats" ></picture><div class="header-feature__content"><h2 class="header-feature__heading">About Element</h2><div class="header-feature__text">Our mission is to empower the scientific community with more freedom and flexibility to accelerate our collective impact on humanity.</div><div class="header-feature__links"><a href="/about" class="button"> More About Element </a></div></div></div></div><div class="header-drop__column -link-group" data-ref="header-subgroup" data-id="7895377" ><div class="header-link -label -hide" data-ref="header-subgroup-label" data-subgroup="7895377" ><span class="bold-shift" data-text="Careers" >Careers</span></div><div class="header-sublinks"><a href="/careers" class="header-link"><span class="bold-shift" data-text="Working At Element">Working At Element</span></a><a href="/careers/openings" class="header-link"><span class="bold-shift" data-text="Open Positions">Open Positions</span></a></div><div class="header-feature"><picture class="header-feature__photo"><source srcset="https://www.elementbiosciences.com/uploads/header/features/_headerFeaturePhotoWebp/7895292/header-company-feature.webp" type="image/webp"><img src="https://www.elementbiosciences.com/uploads/header/features/_headerFeaturePhoto/header-company-feature.png" width="500" height="500" alt="Three Element employees wearing lab coats" ></picture><div class="header-feature__content"><h2 class="header-feature__heading">About Element</h2><div class="header-feature__text">Our mission is to empower the scientific community with more freedom and flexibility to accelerate our collective impact on humanity.</div><div class="header-feature__links"><a href="/about" class="button"> More About Element </a></div></div></div></div></div></div></div></div><a href="https://www.elementbiosciences.com/contact" class="header-action"><div class="header-action__text">Contact Us</div><svg class="header-action__icon"><use xlink:href="/assets/img/icons/glyphs.svg?v=#mail"></use></svg></a></nav></div></div></header><nav class="subnav" data-ref="subnav"><div class="subnav__wrapper"><div class="subnav__label" data-ref="subnav-toggle">Technology - Avidite Base Chemistry</div><div class="subnav__links" data-ref="subnav-links"><a href="/technology/avidite-base-chemistry" class="subnav__link -is-active" > Avidite Base Chemistry </a></div></div></nav><main class="main" role="main"><div class="hero"><div class="container"><div class="hero__row"><div class="hero__content"><ol class="breadcrumbs"><li><a href="/technology">Technology</a></li><li> Avidite Base Chemistry </li></ol><script type="application/ld+json"> { "@context": "http://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Technology", "item": "https://www.elementbiosciences.com/technology" }, { "@type": "ListItem", "position": 2, "name": "Avidite Base Chemistry" } ] } </script><h1 class="hero__heading"> Avidite Base Chemistry </h1><div class="hero__intro"><p>Breakthrough sequencing technology that resets expectations for cost, quality, and flexibility</p></div><div class="hero__links"><a href="https://www.elementbiosciences.com/resources/sequencing-rebuilt" class="button -light -white" > View Infographic </a><a href="https://go.elementbiosciences.com/aviti-sequencing-datasets" class="button -light -white" rel="noreferrer noopener" target="_blank" > Explore Datasets </a></div></div><div class="hero__photo"><picture><img src="https://www.elementbiosciences.com/uploads/heros/_heroPhoto/technology-abc-hero-photo.jpg" width="960" height="640" alt="Avidity Base Chemistry Hero Photo" ></picture></div></div></div></div><div class="technology"><div class="container"><div class="technology__row"><div class="technology__column"><div class="technology-sidebar"><a href="/technology/avidite-base-chemistry" class="technology-sidebar__link -heading" > Avidite Base Chemistry </a></div></div><div class="technology__column"><div class="technology-blocks"><div class="technology-block technology-text"><div class="article"><h2><strong>Introduction to Element technology</strong></h2><p>Avidite base chemistry (ABC) brings a radically different solution to next-generation sequencing (NGS). Unique to Element, ABC reduces run costs and improves performance through innovations across all fronts of surface chemistry, biochemistry, engineering, and data analysis. </p><h3>Low-bind surface chemistry </h3><p>A low-binding surface chemistry captures template DNA on the surface of the flow cell for amplification and sequencing. Entirely new and extensible, the chemistry enables crisp, bright images that elevate the contrast‑to‑noise ratio (CNR) and improve base detection in all four channels. </p><p>Working in tandem with surface chemistry, an optical system featuring an extra-wide field of view images the flow cell with unprecedented range and remarkable edge-to-edge quality. </p><h3>PCR-free amplification </h3><p>Leveraging rolling circle amplification (RCA) for PCR-free amplification prevents template error propagation. In contrast to PCR-based amplification methods, such as bridge amplification, RCA replicates only the original DNA template, rolling each strand into a tightly bound polony consisting of many library copies in close proximity. <br /></p><p>RCA not only provides high-fidelity amplification—it eliminates both optical duplicates and amplification-induced index hopping artifacts. </p><h3>Rebuilt sequencing steps </h3><p>ABC innovates each step of sequencing chemistry, most crucially separating base detection from strand extension to optimize enzyme conditions for each step to deliver unsurpassed accuracy by ensuring ultrapure base-calling signals while reducing costly reagent consumption. </p><p>Additionally, by forgoing modifier nucleotides and fluorescence cleaving, ABC generates scarless, natural DNA that confers superior performance over many cycles of sequencing.</p><figure><img src="https://www.elementbiosciences.com/uploads/technology/_technologyPhoto/Read-Quality-min.png" alt="" /><figcaption>Figure 1. Enzymes built to shorten cycle times also improve base quality, even at 300 bp read ends. Comparing data from human whole-genome libraries demonstrates the ABC accuracy advantage.*</figcaption></figure><h2><strong>Additional ABC advantages </strong></h2><p>ABC supports unique molecular identifiers (UMI), single- or dual-indexing, and single-read or paired-end runs to qualify a breadth of NGS capabilities on a single instrument: </p><ul><li>Short-insert sequencing </li><li>Long-insert sequencing </li><li>Synthetic long reads </li><li>DNA sequencing </li><li>RNA sequencing (RNA-Seq), including single cell </li></ul><p><a href="https://www.elementbiosciences.com/blog/abc-for-ngs-how-to-lower-costs-and-raise-quality" target="_blank" class="button" rel="noopener">Learn more about ABC sequencing</a></p><h2><strong>Cloudbreak™ advancements </strong></h2><p>Cloudbreak is the latest advancement to ABC chemistry, scaling to suit any experiment and enhancing operational efficiency in multiple ways: </p><ul><li>Increase sequencing speed with 20% faster run times reduce 2 x 150 run times to < 40 hours and single cell experiments in less than a day. </li><li>Load a linear library for automatic circularization onboard AVITI. </li><li>Sequence and demultiplex Index 1 and Index 2 before Read 1 and Read 2 for real-time quality control and performance feedback. </li><li>Improve data quality through the end of each read to enhance accuracy. </li><li>Improve sequencing performance through difficult homopolymer regions. </li></ul><p><a href="https://www.elementbiosciences.com/products/cloudbreak" target="_blank" class="button" rel="noopener">Learn more about Cloudbreak kits</a></p><figure class="article-image-center"><img src="https://www.elementbiosciences.com/uploads/technology/_technologyPhoto/Homopolymers.png" alt="" /><figcaption>Figure 2. ABC maintains high read quality after crossing a homopolymer at position 0, demonstrating an unaffected error rate versus SBS’s five-fold increase (left). This exceptional performance extends across most long polymers (> 11 bp) in the human genome (right).*</figcaption></figure><h2><strong>Complete sequencing ecosystem </strong></h2><p>The Element AVITI™ System grounds a prep-to-analysis sequencing portfolio built on ABC. </p><p><a href="https://www.elementbiosciences.com/products/aviti" target="_blank" class="button" rel="noopener">Meet AVITI</a></p><p>* Source: <a href="https://www.nature.com/articles/s41587-023-01750-7" target="_blank" rel="noopener">https://www.nature.com/articles/s41587-023-01750-7</a></p></div></div></div></div></div></div><div class="technology-cta"><div class="container -narrow"><div class="technology-cta__content"><h2 class="technology-cta__heading"> Learn More About Us </h2><div class="technology-cta__links"><a href="/about" class="technology-cta__link button -white"> Learn About Element </a><a href="/legal/patents" class="technology-cta__link button -white"> View Patents </a></div></div></div></div></div></main><footer class="footer" data-ref="footer" role="contentinfo"><div class="footer-content container"><div class="footer-row"><div class="footer-left"><div class="footer-left__wrapper"><div class="footer-tagline">Your Science Can’t Wait</div><div class="footer-social"><a href="https://www.linkedin.com/company/elembio" class="footer-social__link" target="_blank"><svg><use xlink:href="/assets/img/icons/glyphs.svg?v=#linkedin"></use></svg></a><a href="https://twitter.com/elembio" class="footer-social__link" target="_blank"><svg><use xlink:href="/assets/img/icons/glyphs.svg?v=#twitter"></use></svg></a><a href="https://www.youtube.com/@elembio" class="footer-social__link" target="_blank"><svg><use xlink:href="/assets/img/icons/glyphs.svg?v=#youtube"></use></svg></a></div></div></div><div class="footer-right"><picture class="footer-aviti"><source srcset="https://www.elementbiosciences.com/assets/img/footer-aviti-mobile.png" media="(max-width: 454px)"><img src="https://www.elementbiosciences.com/assets/img/footer-aviti-desktop.png" width="1024" height="680" alt="AVITI" ></picture><div class="footer-cta"><div class="footer-cta__wrapper"><strong class="footer-cta__heading"> Have a question? <svg><use xlink:href="/assets/img/icons/glyphs.svg?v=#mail"></use></svg></strong><div class="footer-cta__links"><a href="https://www.elementbiosciences.com/contact" class="button -white -light">Contact Us</a></div></div></div></div></div></div><div class="footer-legal"><div class="container"><div class="footer-legal__wrapper"><span class="footer-legal__copywrite">© Copyright 2024 Element Biosciences</span><div class="footer-legal__links"><a href="https://www.elementbiosciences.com/legal/terms" class="footer-legal__link"> Terms of Use </a><a href="https://www.elementbiosciences.com/uploads/legal/Element-Biosciences-Privacy-Notice-09-05-2024.pdf" class="footer-legal__link" > Privacy Notice </a><a href="https://www.elementbiosciences.com/uploads/legal/Patents-08.19.2024.pdf" class="footer-legal__link" > Patents </a><a href="#" class="footer-legal__link" data-ref="osano-cookie-preferences" > Do Not Sell or Share My Personal Information </a></div></div></div></div></footer></div></body></html>

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