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class="vector-toc-list"> <li id="toc-Etesevimab" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Etesevimab"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.1</span> <span>Etesevimab</span> </div> </a> <ul id="toc-Etesevimab-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Bamlanivimab" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Bamlanivimab"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.2</span> <span>Bamlanivimab</span> </div> </a> <ul id="toc-Bamlanivimab-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Trials" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Trials"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Trials</span> </div> </a> <ul id="toc-Trials-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Economics" class="vector-toc-list-item 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class="firstHeading mw-first-heading"><span class="mw-page-title-main">Bamlanivimab/etesevimab</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. 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<div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Monoclonal antibody combination treatment for COVID-19</div> <p class="mw-empty-elt"> </p> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox" style="border-spacing:2px;"><caption class="infobox-title"><span title="International nonproprietary name (INN): Bamlanivimab/etesevimab">Bamlanivimab/etesevimab</span></caption><tbody><tr><th colspan="2" class="infobox-header" style="background:#ddd">Combination of</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Bamlanivimab" title="Bamlanivimab">Bamlanivimab</a></th><td class="infobox-data"><a href="/wiki/Monoclonal_antibody" title="Monoclonal antibody">Monoclonal antibody</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Etesevimab" class="mw-redirect" title="Etesevimab">Etesevimab</a></th><td class="infobox-data"><a href="/wiki/Monoclonal_antibody" title="Monoclonal antibody">Monoclonal antibody</a></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Clinical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Regulation_of_therapeutic_goods" title="Regulation of therapeutic goods">License data</a></th><td class="infobox-data"><style data-mw-deduplicate="TemplateStyles:r1126788409">.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}</style><div class="plainlist"> <ul><li><small><abbr class="country-name" title="United States">US</abbr></small> <a href="/wiki/DailyMed" title="DailyMed">DailyMed</a>: <span title="dailymed.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=Bamlanivimab">Bamlanivimab</a></span></li></ul></div> </td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Route_of_administration" title="Route of administration">Routes of<br />administration</a></th><td class="infobox-data"><a href="/wiki/Intravenous" class="mw-redirect" title="Intravenous">Intravenous</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Anatomical_Therapeutic_Chemical_Classification_System" title="Anatomical Therapeutic Chemical Classification System">ATC code</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li>None</li></ul></div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Legal status</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Regulation_of_therapeutic_goods" title="Regulation of therapeutic goods">Legal status</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"> <ul><li><small><abbr class="country-name" title="United States">US</abbr>:</small> <a href="/wiki/Prescription_drug" title="Prescription drug">℞-only</a> via emergency use authorization<sup id="cite_ref-Bamlanivimab_FDA_label_1-0" class="reference"><a href="#cite_note-Bamlanivimab_FDA_label-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Etesevimab_FDA_label_2-0" class="reference"><a href="#cite_note-Etesevimab_FDA_label-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FDA_PR_20210209_3-0" class="reference"><a href="#cite_note-FDA_PR_20210209-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FDA_20210916_4-0" class="reference"><a href="#cite_note-FDA_20210916-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FDA_EUA_5-0" class="reference"><a href="#cite_note-FDA_EUA-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup></li></ul></div> </td></tr></tbody></table> <p><b>Bamlanivimab/etesevimab</b> is a combination of two <a href="/wiki/Monoclonal_antibody" title="Monoclonal antibody">monoclonal antibodies</a>, <a href="/wiki/Bamlanivimab" title="Bamlanivimab">bamlanivimab</a> and <b><a href="/wiki/Etesevimab" class="mw-redirect" title="Etesevimab">etesevimab</a></b>, administered together via intravenous infusion as a treatment for <a href="/wiki/COVID-19" title="COVID-19">COVID-19</a>.<sup id="cite_ref-FDA_PR_20210209_3-1" class="reference"><a href="#cite_note-FDA_PR_20210209-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Lilly_PR_20210209_6-0" class="reference"><a href="#cite_note-Lilly_PR_20210209-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid33916927_8-0" class="reference"><a href="#cite_note-pmid33916927-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> Both types of antibody target the <a href="/wiki/Coronavirus_spike_protein" title="Coronavirus spike protein">surface spike protein</a> of <a href="/wiki/SARS%E2%80%91CoV%E2%80%912" class="mw-redirect" title="SARS‑CoV‑2">SARS‑CoV‑2</a>.<sup id="cite_ref-Guide_9-0" class="reference"><a href="#cite_note-Guide-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Lilly_PR_2020-10-28_10-0" class="reference"><a href="#cite_note-Lilly_PR_2020-10-28-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p><p>Bamlanivimab and etesevimab, administered together, are authorized in the United States for the treatment of mild-to-moderate COVID-19 in people aged twelve years of age and older weighing at least 40 kilograms (88 lb) with positive results of direct SARS-CoV-2 viral testing, and who are at high risk for progression to severe COVID-19, including hospitalization or death.<sup id="cite_ref-FDA_20210916_4-1" class="reference"><a href="#cite_note-FDA_20210916-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FDA_EUA_5-1" class="reference"><a href="#cite_note-FDA_EUA-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> They are also authorized, when administered together, for use after exposure to the SARS-CoV-2 virus for <a href="/wiki/Post-exposure_prophylaxis" title="Post-exposure prophylaxis">post-exposure prophylaxis</a> (PEP) for COVID-19 and are not authorized for pre-exposure prophylaxis to prevent COVID-19 before being exposed to the SARS-CoV-2 virus.<sup id="cite_ref-FDA_20210916_4-2" class="reference"><a href="#cite_note-FDA_20210916-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FDA_EUA_5-2" class="reference"><a href="#cite_note-FDA_EUA-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p><p>In January 2022, the U.S. <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> (FDA) revised the authorizations for two monoclonal antibody treatments – bamlanivimab/etesevimab (administered together) and <a href="/wiki/Casirivimab/imdevimab" title="Casirivimab/imdevimab">casirivimab/imdevimab</a> – to limit their use to only when the recipients are likely to have been infected with or exposed to a variant that is susceptible to these treatments.<sup id="cite_ref-FDA_PR_20220124_11-0" class="reference"><a href="#cite_note-FDA_PR_20220124-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> Because data show these treatments are highly unlikely to be active against the <a href="/wiki/SARS-CoV-2_Omicron_variant" title="SARS-CoV-2 Omicron variant">omicron variant</a>, which is circulating at a very high frequency throughout the United States, these treatments are not authorized for use in any U.S. states, territories, and jurisdictions at this time.<sup id="cite_ref-FDA_PR_20220124_11-1" class="reference"><a href="#cite_note-FDA_PR_20220124-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Contents">Contents</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Bamlanivimab/etesevimab&action=edit&section=1" title="Edit section: Contents"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Etesevimab">Etesevimab</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Bamlanivimab/etesevimab&action=edit&section=2" title="Edit section: Etesevimab"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox" style="border-spacing:2px;"><caption class="infobox-title"><span title="International nonproprietary name (INN): Etesevimab">Etesevimab</span></caption><tbody><tr><th colspan="2" class="infobox-header" style="background:#ddd"><a href="/wiki/Monoclonal_antibody" title="Monoclonal antibody">Monoclonal antibody</a></th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/File:Engineered_monoclonal_antibodies.svg" title="File:Engineered monoclonal antibodies.svg">Type</a></th><td class="infobox-data">Whole antibody</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Monoclonal_antibody#Production" title="Monoclonal antibody">Source</a></th><td class="infobox-data"><a href="/wiki/Human" title="Human">Human</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Antigen" title="Antigen">Target</a></th><td class="infobox-data"><a href="/wiki/Coronavirus_spike_protein" title="Coronavirus spike protein">Spike protein</a> of <a href="/wiki/Severe_acute_respiratory_syndrome_coronavirus_2" class="mw-redirect" title="Severe acute respiratory syndrome coronavirus 2">SARS-CoV-2</a></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Clinical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;">Other names</th><td class="infobox-data">LY3832479, LY-CoV016</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Regulation_of_therapeutic_goods" title="Regulation of therapeutic goods">License data</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"> <ul><li><small><abbr class="country-name" title="United States">US</abbr></small> <a href="/wiki/DailyMed" title="DailyMed">DailyMed</a>: <span title="dailymed.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=Etesevimab">Etesevimab</a></span></li></ul></div> </td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Route_of_administration" title="Route of administration">Routes of<br />administration</a></th><td class="infobox-data"><a href="/wiki/Intravenous" class="mw-redirect" title="Intravenous">Intravenous</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Anatomical_Therapeutic_Chemical_Classification_System" title="Anatomical Therapeutic Chemical Classification System">ATC code</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li>None</li></ul></div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CAS_Registry_Number" title="CAS Registry Number">CAS Number</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="commonchemistry.cas.org"><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=2423948-94-9">2423948-94-9</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/DrugBank" title="DrugBank">DrugBank</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.drugbank.ca"><a rel="nofollow" class="external text" href="https://www.drugbank.ca/drugs/DB15897">DB15897</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Unique_Ingredient_Identifier" title="Unique Ingredient Identifier">UNII</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="precision.fda.gov"><a rel="nofollow" class="external text" href="https://precision.fda.gov/uniisearch/srs/unii/N7Q9NLF11I">N7Q9NLF11I</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/KEGG" title="KEGG">KEGG</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.kegg.jp"><a rel="nofollow" class="external text" href="https://www.kegg.jp/entry/D11944">D11944</a></span></li></ul></div></td></tr></tbody></table> <p>Etesevimab is a monoclonal antibody against the <a href="/wiki/Peplomer" class="mw-redirect" title="Peplomer">surface spike protein</a> of SARS‑CoV‑2.<sup id="cite_ref-Lilly_PR_20210209_6-1" class="reference"><a href="#cite_note-Lilly_PR_20210209-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Guide_9-1" class="reference"><a href="#cite_note-Guide-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p><p>Eli Lilly licensed etesevimab from Junshi Biosciences.<sup id="cite_ref-Lilly_PR_20210209_6-2" class="reference"><a href="#cite_note-Lilly_PR_20210209-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Bamlanivimab">Bamlanivimab</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Bamlanivimab/etesevimab&action=edit&section=3" title="Edit section: Bamlanivimab"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1236090951">.mw-parser-output .hatnote{font-style:italic}.mw-parser-output div.hatnote{padding-left:1.6em;margin-bottom:0.5em}.mw-parser-output .hatnote i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Bamlanivimab" title="Bamlanivimab">Bamlanivimab</a></div> <p>Bamlanivimab is an IgG1 monoclonal antibody (mAb) directed against the spike protein of <a href="/wiki/SARS%E2%80%91CoV%E2%80%912" class="mw-redirect" title="SARS‑CoV‑2">SARS‑CoV‑2</a>. The aim is to block viral attachment and entry into human cells, thus neutralizing the virus, and help preventing and treating COVID-19.<sup id="cite_ref-Lilly_PR_2020-10-28_10-1" class="reference"><a href="#cite_note-Lilly_PR_2020-10-28-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Trials">Trials</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Bamlanivimab/etesevimab&action=edit&section=4" title="Edit section: Trials"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The data supporting the emergency use authorization (EUA) for bamlanivimab and etesevimab are based on a randomized, double-blind, placebo-controlled clinical trial in 1,035 non-hospitalized participants with mild to moderate COVID-19 symptoms who were at high risk for progressing to severe COVID-19.<sup id="cite_ref-FDA_PR_20210209_3-2" class="reference"><a href="#cite_note-FDA_PR_20210209-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> Of these participants, 518 received a single infusion of bamlanivimab 2,800 milligrams and etesevimab 2,800 milligrams together, and 517 received placebo.<sup id="cite_ref-FDA_PR_20210209_3-3" class="reference"><a href="#cite_note-FDA_PR_20210209-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> The primary endpoint was COVID-19 related hospitalizations or death by any cause during 29 days of follow-up.<sup id="cite_ref-FDA_PR_20210209_3-4" class="reference"><a href="#cite_note-FDA_PR_20210209-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> Hospitalization or death occurred in 36 (7%) participants who received placebo compared to 11 (2%) participants treated with bamlanivimab 2,800 milligrams and etesevimab 2,800 milligrams administered together, a 70% reduction.<sup id="cite_ref-FDA_PR_20210209_3-5" class="reference"><a href="#cite_note-FDA_PR_20210209-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> All ten deaths (2%) occurred in the placebo group.<sup id="cite_ref-FDA_PR_20210209_3-6" class="reference"><a href="#cite_note-FDA_PR_20210209-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> Thus, all-cause death was significantly lower in the bamlanivimab 2,800-milligram and etesevimab 2,800-milligram group than the placebo group.<sup id="cite_ref-FDA_PR_20210209_3-7" class="reference"><a href="#cite_note-FDA_PR_20210209-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Economics">Economics</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Bamlanivimab/etesevimab&action=edit&section=5" title="Edit section: Economics"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>In February 2021, the United States government agreed to purchase 100,000 doses of the drug for $210 million, at $2,100 per dose.<sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Research">Research</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Bamlanivimab/etesevimab&action=edit&section=6" title="Edit section: Research"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="COVID-19">COVID-19</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Bamlanivimab/etesevimab&action=edit&section=7" title="Edit section: COVID-19"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>In February 2021, the FDA issued an emergency use authorization (EUA) for bamlanivimab and <a href="/wiki/Etesevimab" class="mw-redirect" title="Etesevimab">etesevimab</a> administered together for the treatment of mild to moderate COVID-19 in people twelve years of age or older weighing at least 40 kilograms (88 lb) who test positive for SARS‑CoV‑2 and who are at high risk for progressing to severe COVID-19.<sup id="cite_ref-FDA_20210916_4-3" class="reference"><a href="#cite_note-FDA_20210916-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FDA_EUA_5-3" class="reference"><a href="#cite_note-FDA_EUA-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> The authorized use includes treatment for those who are 65 years of age or older or who have certain chronic medical conditions. While bamlanivimab and etesevimab administered together resulted in a lower risk of resistant viruses developing during treatment compared with bamlanivimab administered alone, both treatments are available under an EUA and are expected to benefit people at high risk of disease progression.<sup id="cite_ref-FDA_PR_20210209_3-8" class="reference"><a href="#cite_note-FDA_PR_20210209-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> On 16 April 2021, the FDA revoked the emergency use authorization (EUA) that allowed for the investigational monoclonal antibody therapy bamlanivimab, when administered alone, to be used for the treatment of mild-to-moderate COVID-19 in adults and certain pediatric patients.<sup id="cite_ref-FDA_PR_20210416_13-0" class="reference"><a href="#cite_note-FDA_PR_20210416-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> The EUA was issued to Eli Lilly and Co.<sup id="cite_ref-FDA_PR_20210209_3-9" class="reference"><a href="#cite_note-FDA_PR_20210209-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p><p>In February 2021, the <a href="/wiki/Committee_for_Medicinal_Products_for_Human_Use" title="Committee for Medicinal Products for Human Use">Committee for Medicinal Products for Human Use</a> (CHMP) of the <a href="/wiki/European_Medicines_Agency" title="European Medicines Agency">European Medicines Agency</a> (EMA) started rolling reviews of data on the use of the monoclonal antibodies <a href="/wiki/Casirivimab/imdevimab" title="Casirivimab/imdevimab">casirivimab/imdevimab</a>, bamlanivimab/etesevimab, and <a href="/wiki/Bamlanivimab" title="Bamlanivimab">bamlanivimab</a> for the treatment of COVID-19.<sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> In March 2021, the CHMP concluded that bamlanivimab and etesevimab can be used together to treat confirmed COVID-19 in people who do not require supplemental oxygen and who are at high risk of their COVID-19 disease becoming severe.<sup id="cite_ref-CHMP_20210305_15-0" class="reference"><a href="#cite_note-CHMP_20210305-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> The CHMP also looked at the use of bamlanivimab alone and concluded that, despite uncertainties around the benefits of monotherapy, it can be considered a treatment option.<sup id="cite_ref-CHMP_20210305_15-1" class="reference"><a href="#cite_note-CHMP_20210305-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> In October 2021, the CHMP ended the rolling review of bamlanivimab/etesevimab.<sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Bamlanivimab/etesevimab&action=edit&section=8" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-Bamlanivimab_FDA_label-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-Bamlanivimab_FDA_label_1-0">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c7e9d8a6-e8c2-4681-9362-51d5bdbae00d">"Bamlanivimab injection, solution"</a>. <i>DailyMed</i><span class="reference-accessdate">. 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Archived from <span class="id-lock-registration" title="Free registration required"><a rel="nofollow" class="external text" href="https://www.nytimes.com/2021/02/26/world/bamlanivimab-etesevimab-eli-lilly-monoclonal-antibodies.html">the original</a></span> on 20 September 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">30 September</span> 2021</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+New+York+Times&rft.atitle=The+Biden+administration+buys+100%2C000+doses+of+a+combination+antibody+treatment+for+high-risk+Covid-19+patients&rft.date=2021-02-26&rft_id=https%3A%2F%2Fwww.nytimes.com%2F2021%2F02%2F26%2Fworld%2Fbamlanivimab-etesevimab-eli-lilly-monoclonal-antibodies.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABamlanivimab%2Fetesevimab" class="Z3988"></span></span> </li> <li id="cite_note-FDA_PR_20210416-13"><span class="mw-cite-backlink"><b><a href="#cite_ref-FDA_PR_20210416_13-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation pressrelease cs1"><a rel="nofollow" class="external text" href="https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-revokes-emergency-use-authorization-monoclonal-antibody-bamlanivimab">"Coronavirus (COVID-19) Update: FDA Revokes Emergency Use Authorization for Monoclonal Antibody Bamlanivimab"</a>. <i>U.S. <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> (FDA)</i> (Press release). 16 April 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">16 April</span> 2021</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Coronavirus+%28COVID-19%29+Update%3A+FDA+Revokes+Emergency+Use+Authorization+for+Monoclonal+Antibody+Bamlanivimab&rft.date=2021-04-16&rft_id=https%3A%2F%2Fwww.fda.gov%2Fnews-events%2Fpress-announcements%2Fcoronavirus-covid-19-update-fda-revokes-emergency-use-authorization-monoclonal-antibody-bamlanivimab&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABamlanivimab%2Fetesevimab" class="Z3988"></span> <span class="noviewer" typeof="mw:File"><span><img alt="Public Domain" src="//upload.wikimedia.org/wikipedia/en/thumb/6/62/PD-icon.svg/12px-PD-icon.svg.png" decoding="async" width="12" height="12" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/6/62/PD-icon.svg/18px-PD-icon.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/6/62/PD-icon.svg/24px-PD-icon.svg.png 2x" data-file-width="196" data-file-height="196" /></span></span> This article incorporates text from this source, which is in the <a href="/wiki/Public_domain" title="Public domain">public domain</a>.</span> </li> <li id="cite_note-14"><span class="mw-cite-backlink"><b><a href="#cite_ref-14">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation pressrelease cs1"><a rel="nofollow" class="external text" href="https://www.ema.europa.eu/en/news/ema-reviewing-data-monoclonal-antibody-use-covid-19">"EMA reviewing data on monoclonal antibody use for COVID-19"</a> (Press release). <a href="/wiki/European_Medicines_Agency" title="European Medicines Agency">European Medicines Agency</a> (EMA). 4 February 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">4 March</span> 2021</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=EMA+reviewing+data+on+monoclonal+antibody+use+for+COVID-19&rft.pub=European+Medicines+Agency+%28EMA%29&rft.date=2021-02-04&rft_id=https%3A%2F%2Fwww.ema.europa.eu%2Fen%2Fnews%2Fema-reviewing-data-monoclonal-antibody-use-covid-19&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABamlanivimab%2Fetesevimab" class="Z3988"></span></span> </li> <li id="cite_note-CHMP_20210305-15"><span class="mw-cite-backlink">^ <a href="#cite_ref-CHMP_20210305_15-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-CHMP_20210305_15-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation pressrelease cs1"><a rel="nofollow" class="external text" href="https://www.ema.europa.eu/en/news/ema-issues-advice-use-antibody-combination-bamlanivimab-etesevimab">"EMA issues advice on use of antibody combination (bamlanivimab / etesevimab)"</a> (Press release). <a href="/wiki/European_Medicines_Agency" title="European Medicines Agency">European Medicines Agency</a> (EMA). 5 March 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">5 March</span> 2021</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=EMA+issues+advice+on+use+of+antibody+combination+%28bamlanivimab+%2F+etesevimab%29&rft.pub=European+Medicines+Agency+%28EMA%29&rft.date=2021-03-05&rft_id=https%3A%2F%2Fwww.ema.europa.eu%2Fen%2Fnews%2Fema-issues-advice-use-antibody-combination-bamlanivimab-etesevimab&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABamlanivimab%2Fetesevimab" class="Z3988"></span> Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.</span> </li> <li id="cite_note-16"><span class="mw-cite-backlink"><b><a href="#cite_ref-16">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ema.europa.eu/en/medicines/human/withdrawn-applications/bamlanivimab-etesevimab-covid-19">"Bamlanivimab and etesevimab for COVID-19: Withdrawn application"</a>. <i>European Medicines Agency</i>. 2 November 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">4 November</span> 2021</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=European+Medicines+Agency&rft.atitle=Bamlanivimab+and+etesevimab+for+COVID-19%3A+Withdrawn+application&rft.date=2021-11-02&rft_id=https%3A%2F%2Fwww.ema.europa.eu%2Fen%2Fmedicines%2Fhuman%2Fwithdrawn-applications%2Fbamlanivimab-etesevimab-covid-19&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABamlanivimab%2Fetesevimab" class="Z3988"></span></span> </li> <li id="cite_note-17"><span class="mw-cite-backlink"><b><a href="#cite_ref-17">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation pressrelease cs1"><a rel="nofollow" class="external text" href="https://www.ema.europa.eu/en/news/ema-ends-rolling-review-antibodies-bamlanivimab-etesevimab-covid-19-following-withdrawal-lilly">"EMA ends rolling review of the antibodies bamlanivimab and etesevimab for COVID-19 following withdrawal by Lilly"</a>. <i><a href="/wiki/European_Medicines_Agency" title="European Medicines Agency">European Medicines Agency</a> (EMA)</i> (Press release). 2 November 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">4 November</span> 2021</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=EMA+ends+rolling+review+of+the+antibodies+bamlanivimab+and+etesevimab+for+COVID-19+following+withdrawal+by+Lilly&rft.date=2021-11-02&rft_id=https%3A%2F%2Fwww.ema.europa.eu%2Fen%2Fnews%2Fema-ends-rolling-review-antibodies-bamlanivimab-etesevimab-covid-19-following-withdrawal-lilly&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABamlanivimab%2Fetesevimab" class="Z3988"></span></span> </li> </ol></div></div> <p><span class="noviewer" typeof="mw:File"><span><img alt="Public Domain" src="//upload.wikimedia.org/wikipedia/en/thumb/6/62/PD-icon.svg/12px-PD-icon.svg.png" decoding="async" width="12" height="12" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/6/62/PD-icon.svg/18px-PD-icon.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/6/62/PD-icon.svg/24px-PD-icon.svg.png 2x" data-file-width="196" data-file-height="196" /></span></span> This article incorporates <a href="/wiki/Copyright_status_of_works_by_the_federal_government_of_the_United_States" title="Copyright status of works by the federal government of the United States">public domain material</a> from the <a rel="nofollow" class="external text" href="https://www.fda.gov/">United States Department of Health and Human Services</a> </p> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Bamlanivimab/etesevimab&action=edit&section=9" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a rel="nofollow" class="external text" href="https://www.fda.gov/media/144118/download">Emergency Use Authorization (EUA) review for bamlanivimab</a></li> <li><a rel="nofollow" class="external text" href="https://www.fda.gov/media/145801/download">Emergency Use Authorization (EUA) for bamlanivimab/etesevimab</a></li> <li><a rel="nofollow" class="external text" href="https://www.fda.gov/media/145802/download">Frequently Asked Questions on the Emergency Use Authorization for bamlanivimab and etesevimab</a></li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output .hlist dl ol,.mw-parser-output .hlist dl ul,.mw-parser-output .hlist ol dl,.mw-parser-output .hlist ol ol,.mw-parser-output .hlist ol ul,.mw-parser-output .hlist ul dl,.mw-parser-output .hlist ul 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navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="Human" scope="row" class="navbox-group" style="width:1%">Human</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Efungumab" title="Efungumab">Efungumab</a><sup>†</sup></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Virus" title="Virus">Viral</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Human</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Ansuvimab" title="Ansuvimab">Ansuvimab</a></li> <li><a href="/wiki/Atoltivimab" title="Atoltivimab">Atoltivimab</a> (<a href="/wiki/Atoltivimab/maftivimab/odesivimab" title="Atoltivimab/maftivimab/odesivimab">+maftivimab/odesivimab</a>)</li> <li><a href="/w/index.php?title=Avdoralimab&action=edit&redlink=1" class="new" title="Avdoralimab (page does not exist)">Avdoralimab</a><sup>§</sup></li> <li><a href="/wiki/Bamlanivimab" title="Bamlanivimab">Bamlanivimab</a><sup>†</sup> (<a class="mw-selflink selflink">+etesevimab</a>)<sup>†</sup></li> <li><a href="/wiki/Bebtelovimab" title="Bebtelovimab">Bebtelovimab</a><sup>§</sup></li> <li><a href="/wiki/Casirivimab" class="mw-redirect" title="Casirivimab">Casirivimab</a><sup>†</sup> (<a href="/wiki/Casirivimab/imdevimab" title="Casirivimab/imdevimab">+imdevimab</a>)</li> <li><a href="/wiki/Cilgavimab" class="mw-redirect" title="Cilgavimab">Cilgavimab</a><sup>†</sup> (<a href="/wiki/Tixagevimab/cilgavimab" title="Tixagevimab/cilgavimab">+tixagevimab</a>)<sup>†</sup></li> <li><a href="/wiki/Diridavumab" title="Diridavumab">Diridavumab</a><sup>§</sup></li> <li><a href="/wiki/Etesevimab" class="mw-redirect" title="Etesevimab">Etesevimab</a><sup>†</sup></li> <li><a href="/wiki/Exbivirumab" title="Exbivirumab">Exbivirumab</a><sup>§</sup></li> <li><a href="/wiki/Foravirumab" title="Foravirumab">Foravirumab</a><sup>§</sup></li> <li><a href="/wiki/Imdevimab" class="mw-redirect" title="Imdevimab">Imdevimab</a><sup>†</sup> (<a href="/wiki/Casirivimab/imdevimab" title="Casirivimab/imdevimab">+casirivimab</a>)</li> <li><a href="/wiki/Libivirumab" title="Libivirumab">Libivirumab</a><sup>§</sup></li> <li><a href="/wiki/Maftivimab" title="Maftivimab">Maftivimab</a></li> <li><a href="/wiki/Nirsevimab" title="Nirsevimab">Nirsevimab</a><sup>†</sup></li> <li><a href="/wiki/Odesivimab" title="Odesivimab">Odesivimab</a></li> <li><a href="/wiki/Pemivibart" title="Pemivibart">Pemivibart</a></li> <li><a href="/wiki/Rafivirumab" title="Rafivirumab">Rafivirumab</a><sup>§</sup></li> <li><a href="/wiki/Regavirumab" title="Regavirumab">Regavirumab</a><sup>§</sup></li> <li><a href="/wiki/Regdanvimab" title="Regdanvimab">Regdanvimab</a></li> <li><a href="/wiki/Sevirumab" title="Sevirumab">Sevirumab</a><sup>†</sup></li> <li><a href="/wiki/Sotrovimab" title="Sotrovimab">Sotrovimab</a></li> <li><a href="/wiki/Suptavumab" title="Suptavumab">Suptavumab</a></li> <li><a href="/wiki/Tixagevimab" class="mw-redirect" title="Tixagevimab">Tixagevimab</a><sup>†</sup> (<a href="/wiki/Tixagevimab/cilgavimab" title="Tixagevimab/cilgavimab">+cilgavimab</a>)<sup>†</sup></li> <li><a href="/wiki/Tuvirumab" title="Tuvirumab">Tuvirumab</a><sup>§</sup></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Chimeric_antibody" class="mw-redirect" title="Chimeric antibody">Chimeric</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/ZMapp" title="ZMapp">Cosfroviximab</a></li> <li><a href="/wiki/ZMapp" title="ZMapp">Larcaviximab</a></li> <li><a href="/wiki/ZMapp" title="ZMapp">Porgaviximab</a></li> <li><a href="/wiki/Vilobelimab" title="Vilobelimab">Vilobelimab</a><sup>†</sup></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Humanized_antibody" title="Humanized antibody">Humanized</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Felvizumab" title="Felvizumab">Felvizumab</a><sup>§</sup></li> <li><a href="/wiki/Lenvervimab" title="Lenvervimab">Lenvervimab</a><sup>†</sup></li> <li><a href="/wiki/Motavizumab" title="Motavizumab">Motavizumab</a><sup>†</sup></li> <li><a href="/wiki/Palivizumab" title="Palivizumab">Palivizumab</a></li> <li><a href="/wiki/Suvizumab" title="Suvizumab">Suvizumab</a><sup>§</sup></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Bacterial" class="mw-redirect" title="Bacterial">Bacterial</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Human</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Nebacumab" title="Nebacumab">Nebacumab</a></li> <li><a href="/wiki/Panobacumab" title="Panobacumab">Panobacumab</a><sup>§</sup></li> <li><a href="/wiki/Raxibacumab" title="Raxibacumab">Raxibacumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Mouse</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Edobacomab" title="Edobacomab">Edobacomab</a><sup>§</sup></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Chimeric_antibody" class="mw-redirect" title="Chimeric antibody">Chimeric</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Pagibaximab" title="Pagibaximab">Pagibaximab</a><sup>†</sup></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Humanized</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Tefibazumab" title="Tefibazumab">Tefibazumab</a><sup>†</sup></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Toxin" title="Toxin">Toxin</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Human</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Actoxumab" title="Actoxumab">Actoxumab</a><sup>§</sup></li> <li><a href="/wiki/Bezlotoxumab" title="Bezlotoxumab">Bezlotoxumab</a></li> <li><a href="/wiki/Suvratoxumab" title="Suvratoxumab">Suvratoxumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Chimeric</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Obiltoxaximab" title="Obiltoxaximab">Obiltoxaximab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Humanized</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Urtoxazumab" title="Urtoxazumab">Urtoxazumab</a><sup>§</sup></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div><div class="hlist"> <ul><li><sup>#</sup><a href="/wiki/WHO_Model_List_of_Essential_Medicines" title="WHO Model List of Essential Medicines">WHO-EM</a></li> <li><sup>‡</sup><a href="/wiki/List_of_withdrawn_drugs" title="List of withdrawn drugs">Withdrawn</a> from market</li> <li><a href="/wiki/Clinical_trial" title="Clinical trial">Clinical trials</a>: <ul><li><sup>†</sup><a href="/wiki/Phases_of_clinical_research#Phase_III" title="Phases of clinical research">Phase III</a></li> <li><sup>§</sup>Never to phase III</li></ul></li></ul> </div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Eli_Lilly_and_Company" style="padding:3px"><table class="nowraplinks hlist mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Eli_Lilly_and_Company" title="Template:Eli Lilly and Company"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Eli_Lilly_and_Company" title="Template talk:Eli Lilly and Company"><abbr title="Discuss this 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Lechleiter">John C. Lechleiter</a></li> <li><a href="/wiki/Ralph_Alvarez" title="Ralph Alvarez">Ralph Alvarez</a></li> <li><a href="/wiki/Winfried_Bischoff" title="Winfried Bischoff">Sir Winfried Bischoff</a></li> <li><a href="/wiki/Michael_L._Eskew" title="Michael L. Eskew">Michael L. Eskew</a></li> <li><a href="/wiki/Martin_Feldstein" title="Martin Feldstein">Martin S. Feldstein</a></li> <li><a href="/w/index.php?title=J._Erik_Fyrwald&action=edit&redlink=1" class="new" title="J. Erik Fyrwald (page does not exist)">J. Erik Fyrwald</a></li> <li><a href="/wiki/Alfred_G._Gilman" title="Alfred G. Gilman">Alfred G. Gilman</a></li> <li><a href="/wiki/Karen_N._Horn" title="Karen N. Horn">Karen N. Horn</a></li> <li><a href="/w/index.php?title=Ellen_R._Marram&action=edit&redlink=1" class="new" title="Ellen R. Marram (page does not exist)">Ellen R. Marram</a></li> <li><a href="/wiki/Douglas_R._Oberhelman" class="mw-redirect" title="Douglas R. Oberhelman">Douglas R. Oberhelman</a></li> <li><a href="/w/index.php?title=Franklyn_G._Prendergast&action=edit&redlink=1" class="new" title="Franklyn G. Prendergast (page does not exist)">Franklyn G. Prendergast</a></li> <li><a href="/wiki/Kathi_Seifert" title="Kathi Seifert">Kathi P. 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