Human Mesenchymal Stem Cell Functional Identification Kit (SC006) by R&D Systems, Part of Bio-Techne

<!DOCTYPE html> <html lang="en" dir="ltr" prefix="og: https://ogp.me/ns#"> <head> <meta charset="utf-8" /> <noscript><style>form.antibot * :not(.antibot-message) { display: none !important; }</style> </noscript><meta name="applicable-device" content="pc,mobile" /> <link rel="canonical" href="https://www.bio-techne.com/p/stem-cell/human-mesenchymal-stem-cell-functional-identification-kit_sc006" /> <meta property="og:site_name" content="Bio-Techne" /> <meta property="og:type" content="Website" /> <meta property="og:url" content="https://www.bio-techne.com/" /> <meta property="og:title" content="Human Mesenchymal Stem Cell Functional Identification Kit (SC006) by R&D Systems, Part of Bio-Techne" /> <meta name="Generator" content="Drupal 10 (https://www.drupal.org)" /> <meta name="MobileOptimized" content="width" /> <meta name="HandheldFriendly" content="true" /> <meta name="viewport" content="width=device-width, initial-scale=1.0" /> <script type="application/ld+json">{ "@context": "https://schema.org", "@graph": [ { "@type": "WebPage", "@id": "https://www.bio-techne.com/p/stem-cell/human-mesenchymal-stem-cell-functional-identification-kit_sc006", "breadcrumb": { "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bio-techne.com/" }, { "@type": "ListItem", "position": 2, "name": "Mesenchymal Stem Cells", "item": "https://www.bio-techne.com/t/mesenchymal-stem-cells" }, { "@type": "ListItem", "position": 3, "name": "Mesenchymal Stem Cells Stem Cell Products", "item": "https://www.bio-techne.com/t/mesenchymal-stem-cells/stem-cell" } ] } } ] }</script> <meta http-equiv="x-dns-prefetch-control" content="on" /> <meta http-equiv="x-ua-compatible" content="ie=edge" /> <meta name="keywords" content="SC006, hMesenchymal Func Ident Kit, SCOO6, trilineage, tri-lineage, pluritest, MSC" /> <meta name="description" content="View Human Mesenchymal Stem Cell Functional Identification Kit for Stem Cell Products. Used in 69 publications." /> <script type="application/ld+json" id="json-ld">[{"@context":"http://schema.org","@type":"Product","additionalProperty":[],"aggregateRating":{"@type":"AggregateRating","ratingValue":5,"reviewCount":1,"worstRating":"1","bestRating":"5"},"alternateName":"","brand":{"@type":"Brand","name":"R&D Systems"},"description":"Human Mesenchymal Stem Cell Functional Identification Kit","image":[{"@type":"ImageObject","url":"https://resources.bio-techne.com/images/products/Human_Mesenchymal_Stem_Cell_Functional_Identification_Kit_SC006_Verification_of_Multipotency_ICC_Large.jpg","description":"Verification of Multipotency using the Human Mesenchymal Stem Cell Functional Identification Kit.\u00a0"}],"isRelatedTo":[{"@type":"Product","brand":{"@type":"Brand","name":"R&D Systems"},"description":"MycoProbe Mycoplasma Detection Kit","image":[{"@type":"ImageObject","url":"https://resources.bio-techne.com/images/products/MycoProbe_Mycoplasma_Detection_Kit_CUL001B_Detection_in_Cell_Line_Supernates_and_Lysates_Large_540.png","description":"Mycoplasma Detection in Cell Line Supernates and Cell Lysates.\u00a0"}],"mpn":"CUL001B","name":"MycoProbe Mycoplasma Detection Kit","sku":"CUL001B","url":"https://www.bio-techne.com/p/cell-culture/mycoprobe-mycoplasma-detection-kit_cul001b"}],"itemcondition":"new","mpn":"SC006","name":"Human Mesenchymal Stem Cell Functional Identification Kit","productID":"SC006","review":[{"@type":"Review","author":{"@type":"Person","name":"Anonymous"},"datePublished":"Oct 17 2016 1:51PM","name":"Human Mesenchymal Stem Cell Functional Identification Kit","reviewRating":{"@type":"Rating","bestRating":"5","ratingValue":5,"worstRating":"1"}}],"sku":"SC006","url":"https://www.bio-techne.com/p/stem-cell/human-mesenchymal-stem-cell-functional-identification-kit_sc006"},{"@context":"http://schema.org","@type":"AskAction","question":[{"@context":"http://schema.org","@type":"Question","name":"Can the Human Mesenchymal Stem Cell Functional Identification Kit (Catalog # SC006) be used with non-human primate mesenchymal stem cells?","identifier":{"@type":"PropertyValue","propertyID":"FaqId","value":33469},"acceptedAnswer":{"@type":"Answer","text":"It is likely that the antibodies included in the kit are cross-reactive to other primates. The supplements included in the kit are not intended to be species-specific. However, the kit has not been tested with primate mesenchymal stem cells"}},{"@context":"http://schema.org","@type":"Question","name":"For the Human Mesenchymal Stem Cell Functional Identification Kit (Catalog # SC006), how can induction of differentiation be monitored?","identifier":{"@type":"PropertyValue","propertyID":"FaqId","value":33471},"acceptedAnswer":{"@type":"Answer","text":"For adipogenic differentiation, the appearance of vacuoles in cells after 5-7 days is a sign of differentiation and can be monitored by microscopic examination of the cells. For osteogenic differentiation, the beginning of cell detachment after about 14 days is a sign of differentiation. Cell detachment should be monitored in this case. For chondrogenic differentiation, there isn't an exact marker to look for other than fixing and staining the frozen pellet between differentiation days 14 - 21. The exact choice of time may take some empirical testing."}},{"@context":"http://schema.org","@type":"Question","name":"In the Human Mesenchymal Stem Cell Functional Identification Kit (Catalog # SC006), are Part #'s 90415, 390416, and 390417 the same as the StemXVivo® Human Adipogenic Supplement (Catalog # CCM011), StemXVivo® Human Osteogenic Supplement (Catalog # CCM008), and StemXVivo® Human Chondrogenic Supplement (Catalog # CCM006), respectively?","identifier":{"@type":"PropertyValue","propertyID":"FaqId","value":33470},"acceptedAnswer":{"@type":"Answer","text":"Yes, the StemXVivo® Human Adipogenic Supplement (Catalog # CCM011), StemXVivo®  Human Osteogenic Supplement (Catalog # CCM008), and StemXVivo® Human Chondrogenic Supplement (Catalog # CCM006) are the same as Part #'s 390415, 390416, and 390417, respectively, in the Human Mesenchymal Stem Cell Functional Identification Kit (Catalog # SC006)."}},{"@context":"http://schema.org","@type":"Question","name":"Are there any experimental tips/hints for successful chondrogenic differentiation of mesenchymal stem cells?","identifier":{"@type":"PropertyValue","propertyID":"FaqId","value":33472},"acceptedAnswer":{"@type":"Answer","text":"The following tips/hints are useful for chondrogenic differentiation:a) The mesenchymal stem cells (MSCs) should not be from a late passage (passage 8 or less), b) if using the Human Mesenchymal Stem Cell Functional Identification Kit (Catalog # SC006) or the StemXVivo® Chondrogenic Supplement (Catalog # CCM006), use the starting MSC cell number that is indicated in the protocol, c) Early during chondrogenic differentiation a pellet should form. As differentiation progresses, the pellet will grow and take up a ball-like appearance. d) The pellet should not attach to the tube, therefore care should be taken to not dislodge it while changing media."}}]}]</script> <link rel="alternate" hreflang="en" href="https://www.bio-techne.com/p/stem-cell/human-mesenchymal-stem-cell-functional-identification-kit_sc006" /> <link rel="alternate" hreflang="zh-hans" href="https://www.bio-techne.com/cn/p/stem-cell/human-mesenchymal-stem-cell-functional-identification-kit_sc006" /> <link rel="icon" href="/themes/custom/bio_techne_global/favicon.ico" type="image/vnd.microsoft.icon" /> <link rel="preconnect" href="https://resources.bio-techne.com" /> <link rel="preconnect" href="https://resources.tocris.com" /> <link rel="preconnect" href="https://i.icomoon.io" /> <link rel="preconnect" href="https://cdn.icomoon.io" /> <link rel="dns-prefetch" href="https://connect.facebook.net" /> <link rel="dns-prefetch" href="https://resources.bio-techne.com" /> 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<div class="sub-menu-header"> Instruments<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/brands/proteinsimple" class="dropdown-item text-wrap" data-drupal-link-system-path="node/3281">ProteinSimple Instruments</a> <a href="/instruments/ice" title="Our capillary electrophoresis instruments (icIEF and CE-SDS) provide reproducible quantitative analysis for thorough therapeutic protein characterization." class="dropdown-item text-wrap" data-drupal-link-system-path="node/256">iCE Maurice</a> <a href="/instruments/imagers" class="dropdown-item text-wrap" data-drupal-link-system-path="node/536">Imagers</a> <a href="/instruments/luminex" class="dropdown-item text-wrap" data-drupal-link-system-path="node/241">Luminex</a> <a href="/instruments/micro-flow-imaging" class="dropdown-item text-wrap" data-drupal-link-system-path="node/526">Micro-Flow Imaging</a> <a href="/instruments/simple-plex" class="dropdown-item text-wrap" data-drupal-link-system-path="node/541">Simple Plex Ella</a> <a href="/instruments/simple-western" class="dropdown-item text-wrap" data-drupal-link-system-path="node/521">Simple Western</a> <a href="/instruments/single-cell-dispensers" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6361">Single Cell Dispensers</a> <a href="/instruments/single-cell-western" class="dropdown-item text-wrap" data-drupal-link-system-path="node/531">Single-Cell Western</a> <a href="/instruments" class="dropdown-item text-wrap" data-drupal-link-system-path="node/13391">View All Instruments</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Applications<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/methods/bioprocessing" class="dropdown-item text-wrap">Bioprocessing</a> <a href="/applications/crispr" class="dropdown-item text-wrap" 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Proteins</a> <a href="/gmp-products/gmp-small-molecules" class="dropdown-item text-wrap" data-drupal-link-system-path="node/366">GMP Small Molecules</a> <a href="/gmp-products/gmp-antibodies" class="dropdown-item text-wrap" data-drupal-link-system-path="node/13266">GMP Antibodies</a> <a href="/gmp-products/gmp-capabilities" class="dropdown-item text-wrap" title="GMP Capabilities" data-drupal-link-system-path="node/1071">GMP Capabilities</a> <a href="/gmp-products/ruo-to-gmp" class="dropdown-item text-wrap" data-drupal-link-system-path="node/3421">Transition to GMP </a> <a href="/gmp-products/loa-request" class="dropdown-item text-wrap" data-drupal-link-system-path="node/13326">DMF/LOA Request</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Instruments<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/brands/proteinsimple" class="dropdown-item text-wrap" data-drupal-link-system-path="node/3281">ProteinSimple Instruments</a> <a href="/instruments/ice" class="dropdown-item text-wrap" data-drupal-link-system-path="node/256">iCE Maurice</a> <a href="/instruments/imagers" class="dropdown-item text-wrap" data-drupal-link-system-path="node/536">Imagers</a> <a href="/instruments/luminex" class="dropdown-item text-wrap" data-drupal-link-system-path="node/241">Luminex</a> <a href="/instruments/micro-flow-imaging" class="dropdown-item text-wrap" data-drupal-link-system-path="node/526">Micro-Flow Imaging</a> <a href="/instruments/simple-plex" class="dropdown-item text-wrap" data-drupal-link-system-path="node/541">Simple Plex Ella</a> <a href="/instruments/simple-western" class="dropdown-item text-wrap" data-drupal-link-system-path="node/521">Simple Western</a> <a href="/instruments/single-cell-dispensers" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6361">Single Cell Dispensers</a> <a href="/instruments/single-cell-western" class="dropdown-item text-wrap" data-drupal-link-system-path="node/531">Single Cell Western</a> <a href="/instruments" class="dropdown-item text-wrap" data-drupal-link-system-path="node/13391">View All Instruments</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Applications<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/methods/bioprocessing" class="dropdown-item text-wrap">Bioprocessing</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Research Areas<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/research-areas/cell-and-gene-therapy" class="dropdown-item text-wrap" data-drupal-link-system-path="node/51">Cell & Gene Therapy</a> <a href="/applications/immuno-oncology-clinical" class="dropdown-item text-wrap" data-drupal-link-system-path="node/2066">Immuno-Oncology</a> </div> </div> </div> </div> </div> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdown-diagnostics" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false"> Diagnostics <span class="icon-bt-icon-caret-cropped menu-caret js-caret d-inline-block"></span> </a> <div class="dropdown-menu dropdown-menu-diagnostics" aria-labelledby="navbarDropdown-diagnostics"> <div class="row"> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Controls & Reagents<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/diagnostics/clinical-quality-controls" class="dropdown-item text-wrap" data-drupal-link-system-path="node/7606">Clinical Quality Controls</a> <a href="/diagnostics/molecular-quality-controls" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5596">Molecular Controls</a> <a href="/diagnostics/controls-reagents/rnascope-ish-probe-high-risk-hpv" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5981">RNAscope™ ISH Probe High Risk HPV</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Kits<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/diagnostics/amplidex-genetic-testing-kits" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5581">Genetics</a> <a href="/diagnostics/quantidex-oncology-testing-kits" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5586">Oncology</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Technology<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/diagnostics/exosome" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5486">Exosome Platform</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> OEM Services<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/diagnostics/ivd-assay-development" class="dropdown-item text-wrap" data-drupal-link-system-path="node/10881">IVD Assay Development</a> <a href="/diagnostics/ivd-contract-manufacturing" class="dropdown-item text-wrap" data-drupal-link-system-path="node/7381">IVD Contract Manufacturing</a> <a href="/diagnostics/molecular-quality-controls/oem-and-commercial-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6781">Molecular Diagnostic OEM Services</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Companion Diagnostics<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/diagnostics/companion-diagnostics" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5631">Companion Diagnostics Services</a> <a href="/diagnostics/companion-diagnostics/multiomics" class="dropdown-item text-wrap" data-drupal-link-system-path="node/10616">Multiomics Platform</a> </div> </div> </div> </div> </div> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdown-services" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false"> Services <span class="icon-bt-icon-caret-cropped menu-caret js-caret d-inline-block"></span> </a> <div class="dropdown-menu dropdown-menu-services" aria-labelledby="navbarDropdown-services"> <div class="row"> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Custom Quotes<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/services/bulk-quotes" class="dropdown-item text-wrap" data-drupal-link-system-path="services/bulk-quotes">Bulk Quote Discounts</a> <a href="/services/custom-formulation" class="dropdown-item text-wrap" data-drupal-link-system-path="services/custom-formulation">Custom Formulation Quotes</a> <a href="/reagents/rnascope-ish-technology/probes/custom" class="dropdown-item text-wrap" data-drupal-link-system-path="node/12571">RNAscope Custom Probe Design Quote</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Custom Services<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/services/custom-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/1891">All Custom Services</a> <a href="/services/custom-antibody-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/906">Custom Antibody Services</a> <a href="/services/custom-cell-and-gene-therapy-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/1281">Custom Cell & Gene Therapy Services</a> <a href="/services/custom-compound-library-service" class="dropdown-item text-wrap" data-drupal-link-system-path="node/2126">Custom Compound Library Services</a> <a href="/services/custom-elisa-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/261">Custom ELISA Services</a> <a href="/services/gene-engineering-services-tcbuster" class="dropdown-item text-wrap" title="Gene Engineering Services: Bio-Techne" data-drupal-link-system-path="node/1136">Custom Gene Engineering Services</a> <a href="/services/custom-luminex-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/271">Custom Luminex Services</a> <a href="/services/custom-protein-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/1441">Custom Protein Services</a> <a href="/services/custom-simple-plex-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6296">Custom Simple Plex Services</a> <a href="/services/custom-targeted-protein-degradation-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/861">Custom Targeted Protein Degradation Services</a> <a href="/services/professional-assay-services-rnascope" class="dropdown-item text-wrap" data-drupal-link-system-path="node/12306">RNAscope Professional Assay Services</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Instrument Services<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/services/certified-service-provider-program" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5446">Certified Service Provider (CSP) Program</a> <a href="/resources/instrument-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5471">Contract Services</a> <a href="/services/instrument-services/simple-western-service-plans" class="dropdown-item text-wrap" data-drupal-link-system-path="node/3181">Simple Western Service Plans</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Licensing<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/services/biotechnology-licensing-partnering" class="dropdown-item text-wrap" data-drupal-link-system-path="node/1101">Biotechnology Licensing and Partnering</a> </div> </div> </div> </div> </div> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdown-resources" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false"> Resources <span class="icon-bt-icon-caret-cropped menu-caret js-caret d-inline-block"></span> </a> <div class="dropdown-menu dropdown-menu-resources" aria-labelledby="navbarDropdown-resources"> <div class="row"> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Product & Instrument Tools<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/resources/cofa-finder-tool" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/cofa-finder-tool">Certificate of Analysis (COA) Finder Tool</a> <a href="/resources/calculators" class="dropdown-item text-wrap" data-drupal-link-system-path="node/7416">Calculators</a> <a href="/resources/flow-cytometry-panel-builder" class="dropdown-item text-wrap" data-drupal-link-system-path="node/8821">Flow Cytometry Panel Builder</a> <a href="/luminex-assay-customization-tool" class="dropdown-item text-wrap" data-drupal-link-system-path="luminex-assay-customization-tool">Luminex Assay Customization Tool</a> <a href="/resources/product-insert-lookup-tool" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/product-insert-lookup-tool">Product Insert Lookup Tool</a> <a href="/resources/rnascope-citations" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/rnascope-citations">RNAscope Citations</a> <a href="/resources/simple-plex-panel-builder" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/simple-plex-panel-builder">Simple Plex Panel Builder</a> <a href="/resources/simple-western-kit-builder" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/simple-western-kit-builder">Simple Western Kit Builder</a> <a href="/resources/simple-western-antibody-database" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/simple-western-antibody-database">Simple Western Antibody Database</a> <a href="/resources/single-cell-western-antibody-database" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/single-cell-western-antibody-database">Single-Cell Western Antibody Database</a> <a href="/resources/spectra-viewer" class="dropdown-item text-wrap" 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" title="Verification of Multipotency using the Human Mesenchymal Stem Cell Functional Identification Kit. " data-caption="Human mesenchymal stem cells were cultured in StemXVivo<sup>®</sup>Mesenchymal Stem Cell Expansion Media (Catalog # <a class="NoLineLink" href="/p/cell-culture/stemxvivo-mesenchymal-stem-cell-expansion-media_ccm004" target="_self">CCM004</a>) and differentiation was induced as indicated using the media supplements included in the Human Mesenchymal Stem Cell Functional Identification Kit (Catalog # SC006). The kit also contains a Goat Anti-Mouse FABP-4 Antigen Affinity-purified Polyclonal Antibody (adipocytes), a Goat Anti-Human Aggrecan Antigen Affinity-purified Polyclonal Antibody (chondrocytes), and a Mouse Anti-Human Osteocalcin Monoclonal Antibody (osteocytes) for the confirmation of differentiation status. The cells were stained using the NorthernLightsTM 557-conjugated Donkey Anti-Goat (Catalog # <a class="NoLineLink" href="/p/secondary-antibodies/goat-igg-northernlights-nl557-conjugated-antibody_nl001" target="_self">NL001</a>; red) or Anti-Mouse (Catalog # <a class="NoLineLink" href="/p/secondary-antibodies/mouse-igg-northernlights-nl557-conjugated-antibody_nl007" target="_self">NL007</a>; red) IgG Secondary Antibodies, and the nuclei were counterstained with DAPI (blue)." data-badges="" data-application="Cell Proliferation" width="250" height="250" fetchpriority=high as=image class="search_result_thumbnail_image" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </article> </div> <div class="col-xl-8" id="atc_wrapper"><article class="product-data-wrapper"> <div class="atc-container"> <div class="atc-block" data-type="ds" 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data-catalog="SC006" data-hidden=""> <div class="commerce-atc-catnum col-3 col-md-3 pl-0 m-0">SC006</div> <div class="commerce-atc-availability col-md-4 pl-0 m-0 d-none d-md-block"> </div> <div class="commerce-atc-price col-4 col-md-3 pl-0 m-0"> </div> <div class="commerce-atc-quantity col-4 col-md-2 text-right px-0 m-0"> </div> </div> </div> <div class="atc-control ProductCart-control text-right"> <div class="row container d-flex justify-content-end mx-0 mb-3 p-0"> <div class="order-md-last m___button-atc mx-1"> <button type="submit" value="Add To Cart" class="atc-add-button btn a___button-atc m-1 col-xs-4 order-last btn-md-block w-100"> Add To Cart </button> </div> <div class="m___button-atc mx-1"> <a href="" class="atc-print-quote-button btn btn-secondary m-1 col-xs-4 btn-md-block w-100">Print Quote</a> </div> <div class="m___button-atc mx-1"> <a href="/services/bulk-quotes?product_code=SC006" class="atc-bulk-button btn btn-secondary m-1 col-xs-4 btn-md-block w-100" rel="nofollow">Bulk Order</a> </div> </div> </div> </div> </form> </div> </div> </article> </div> </div> <div class="row datapoint_list border-top" id="key_details_wrapper"><div class="col-xl-12 mt-2" id="key_details_col_wrapper"></div> </div> </div> <div class="col-xl-3 mt-2" id="orderinfo_guarantee_wrapper"><div id="order_information_wrapper"><div id="product_shipping_block_wrapper" data-brand="rnd" data-shipping="" data-source="ep-data" data-sub_category_id="109"> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"><span class="sr-only">Loading...</span></div> </div> </div> <div id="video-tile-wrapper"><article class="product-data-wrapper"> <div class="video_tile_wrapper"> <article> <div> <lite-youtube videoid="9QE6w3gImsM" style="background-image: url('https://img.youtube.com/vi/9QE6w3gImsM/maxresdefault.jpg');"> <a href="https://www.youtube.com/embed/9QE6w3gImsM?autoplay=1" class="lty-playbtn" title="Setting the standard in quality research reagents"> <span class="lyt-visually-hidden">Setting the standard in quality research reagents</span> </a> </lite-youtube> </div> </article> </div> </article> </div> <div id="product_ads_wrapper"><article class="product-data-wrapper"> </article> </div> </div> </div> </div> <div class="tab-content rounded-bottom border-0 mb-3 shadow"><div id="about-data-tab-tab"></div> <ul class="nav nav-tabs nav-fill " id="productTab" role="tablist"> <li class="nav-item"> <a class="nav-link active" id="technical-data-tab-tab" href="#technical-data-tab" data-toggle="tab" role="tab" aria-controls="region-4821584720927" aria-selected="true" >Technical Data</a> </li> <li class="nav-item"> <a class="nav-link" id="procedure-tab-tab" href="#procedure-tab" data-toggle="tab" role="tab" aria-controls="region-2811585257724" aria-selected="false" >Procedure</a> </li> <li class="nav-item"> <a class="nav-link" id="citations-reviews-faqs-tab-tab" href="#citations-reviews-faqs-tab" data-toggle="tab" role="tab" aria-controls="region-7631584720992" aria-selected="false" >Citations / Reviews (1) / FAQs</a> </li> </ul> <div class="tab-content rounded-bottom border-left border-right border-bottom mb-3" id="ProductTabContent"><div class="tab-pane fade show active mx-4 cell-culture-gpp" id="technical-data-tab" data-tab-label="Technical Data" role="tabpanel" aria-labelledby="technical-data-tab-tab"><div class="product_details_anchors"><div class="product-pages-anchors nav mx-0 pt-4 pb-2 m___nav-anchors d-none d-lg-flex"><li id="product-summary_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 jump-anchor active" href="#product-summary" id="product-summary_li" >Product Summary</a> </li> <li id="product-specifications_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 jump-anchor" href="#product-specifications" id="product-specifications_li" >Product Specifications</a> </li> <li id="scientific-data_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 jump-anchor" href="#scientific-data" id="scientific-data_li" >Scientific Data</a> </li> <li id="preparation--storage_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 jump-anchor" href="#preparation--storage" id="preparation--storage_li" >Preparation & Storage</a> </li> <li id="product-documents_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 product-documents datasheet_static_link" href="#product-documents" id="product-documents_li" >Product Datasheets</a> </li> </div> <div id="product-summary" class="nav-link px-0" data-anchor-label="Product Summary"><div id="product_title_summary"><h3>Summary for Human Mesenchymal Stem Cell Functional Identification Kit</h3><article class="product-data-wrapper"> <html><body><div class="ds_lightBlueBar">Kit Summary</div> <p>To verify multipotency of human mesenchymal stem cells by in vitro functional differentiation.</p> <div class="grid_6"> <h3>Key Benefits</h3> <ul> <li>Confirms that the starting MSC population is multipotent</li> <li>Can be used with the <a href="/p/flow-cytometry-kits/human-mesenchymal-stem-cell-verification-flow-kit_fmc020">Human MSC Verification Flow Kit</a> to define MSCs according to the ISCT recommendations</li> <li>Reliably induces MSC trilineage differentiation using defined supplements</li> <li>Includes premium quality antibodies to confirm differentiation</li> </ul> </div> <p> </p> <h3>Why Funtionally Verify Human MSC Multipotency <em>In Vitro</em>?</h3> <p>Mesenchymal stem/stromal cells (MSCs) can be characterized based on the expression of specific cell surface markers, the absence of hematopoietic markers, and adherence to plastic <em>in vitro</em>.</p> <p>To more rigorously determine if a cell is truly an MSC, it is important to also verify its ability to differentiate into adipocytes, chondrocytes, and osteocytes.</p> <h4>Functional verification of MSC multipotency <em>in vitro</em>:</h4> <ul> <li>Uses defined supplements to drive reproducible trilineage differentiation.</li> <li>Verifies a healthy, multipotent starting MSC population to increase consistency between studies and reduce unwanted experimental variability.</li> <li>Meets one of the three recommended minimal criteria for MSC identification.</li> </ul> <p> </p> <h4 class="ds_lightBlueBar">Mesenchymal Stromal Cells or Mesenchymal Stem Cells?</h4> <p>The term ‘mesenchymal stromal cells’ is commonly used to describe a heterogeneous population of cultured cells that are adherent to plastic, have a distinct morphology, and express a specific set of marker proteins. Within this heterogeneous population are cells referred to as ‘mesenchymal stem cells.’</p> <p>Mesenchymal stem cells are multipotent, self-renewing cells that have the ability to differentiate into adipocytes, chondrocytes, and osteoblasts when cultured <em>in vitro</em>. <a href="#msc-nomenclature">Read More about MSC Nomenclature</a></p> <p> </p> <h4 class="ds_lightBlueBar">Kit Components</h4> <p>This kit contains the following reagents to drive MSC differentiation and a marker to analyze each of the three differentiated derivatives:</p> <ul> <li>Adipogenic Supplement</li> <li>Chondrogenic Supplement</li> <li>Osteogenic Supplement</li> <li>ITS Supplement</li> <li><em>Adipocyte marker:</em> Goat Anti-Mouse FABP4 Antigen Affinity-purified Polyclonal Antibody</li> <li><em>Chondrocyte marker:</em> Goat Anti-Human Aggrecan Antigen Affinity-purified Polyclonal Antibody</li> <li><em>Osteocyte marker:</em> Mouse Anti-Human Osteocalcin Monoclonal Antibody</li> </ul> <p><em>This kit requires media (not included), such as Human/Mouse/Rat StemXVivo Osteogenic/Adipogenic Base Media (<a href="/p/cell-culture/stemxvivo-osteogenic-adipogenic-base-media_ccm007">CCM007</a>) or equivalent.</em></p> <p>The quantity of each media supplement in this kit is sufficient to make 50 mL of media for differentiation. This is enough media for the differentiation of 16 wells of a 24-well plate for osteogenic and adipogenic lineages and 10 chondrocyte pellets.</p> <h4>Precautions</h4> <a id="data-examples" name="data-examples"></a> <ul> <li>The Adipogenic Supplement contains 95% ethanol and is highly flammable. Keep the container tightly closed, and keep it away from sources of ignition.</li> <li>The acute and chronic effects of over-exposure to the reagents in this kit are unknown. Safe laboratory handling procedures should be followed and protective clothing should be worn when handling kit reagents.</li> <li>The ITS Supplement contains human transferrin. This transferrin was purified from donor plasma and tested at the donor level using an FDA licensed method and found to be non-reactive for anti-HIV-1/2 and Hepatitis B surface antigen. </li> </ul> <h4>2006 Proposed Change to MSC Nomenclature</h4> <p>Although mesenchymal stromal cells were once referred to as ‘mesenchymal stem cells’, a change to ‘mesenchymal stromal cells’ was proposed by the International Society for Cellular Therapy in 2006.<sup id="fnref:fn1"><a href="#fn:fn1" rel="footnote">1</a></sup></p> <p>The change in nomenclature originates from two important factors:</p> <ul> <li>Methods used to isolate mesenchymal stem cells yield a heterogeneous population of cells with only a fraction of these cells demonstrating multipotency.</li> <li>The absence of direct evidence that mesenchymal stem cells can self-renew and differentiate <em>in vivo</em>.</li> </ul> <h4>Use of Mesenchymal Stem and Stromal Cell Terminology</h4> <p>Data supporting MSC self-renewal and multipotency have been obtained using <em>in vitro</em> conditions, which does not adequately reflect the in vivo environment. The lack of <em>in vivo</em> data has led some researchers to question the validity of the term ‘mesenchymal stem cell’ providing further support for the use of ‘mesenchymal stromal cells’ to describe MSCs.<sup id="fnref:fn2"><a href="#fn:fn2" rel="footnote">2</a></sup> While ‘mesenchymal stromal cells’ may be the more scientifically accurate term for MSCs, the two terms are often used interchangeably in the literature. R&D Systems recognizes the use of both mesenchymal stem cells and mesenchymal stromal cells and uses ‘MSC’ to indicate mesenchymal stem/stromal cells to account for both designations.</p> <h4>Definitions of Mesenchymal Stromal Cells and Mesenchymal Stem Cells</h4> <ul> <li>Mesenchymal Stromal Cells – A heterogeneous population of cultured cells with similar characteristics such as the ability to adhere to plastic and the expression of specific marker proteins.</li> <li>Mesenchymal Stem Cells – A subpopulation of mesenchymal stromal cells that have the capacity to self-renew and differentiate into mesodermal lineages when cultured <em>in vitro</em>. The capacity to self-renew and differentiate <em>in vivo</em> has yet to be clearly demonstrated for mesenchymal stem cells.</li> </ul> <h4>References</h4> <ul> <li id="fn:fn1">Dominici, M.<em> et al.</em> (2006) Cytotherapy<strong> 8</strong>:315.</li> <li id="fn:fn2">Keating, A. (2012) Cell Stem Cell <strong>10</strong>:709.</li> </ul></body></html> </article> <article class="product-data-wrapper"> <p>The term 'mesenchymal stem cells' (MSCs) is most commonly used to describe multipotent self-renewing cells that can be differentiated in vitro to generate adipocytes, chondrocytes, and osteoblasts. However, because these biological properties and hierarchical relationships remain to be clearly demonstrated in vivo, the term 'multipotent mesenchymal stromal cells' is often used to distinguish cultured cells from their in vivo precursors. Originally discovered in mouse bone marrow, multipotent mesenchymal stromal cells cultured from a variety of species and tissue types, have been shown to differentiate into progeny of additional lineages including, cardiomyocytes, endothelial cells, hepatocytes, and neural cells. Again, the physiological relevance of these findings remains to be determined.</p><p></p> </article> </div> </div> <div id="product-specifications" class="nav-link px-0" data-anchor-label="Product Specifications"><table class="tablesaw tablesaw-stack table-bordered table" id="product_specification_wrapper"><h3>Product Specifications for Human Mesenchymal Stem Cell Functional Identification Kit</h3><tr class="product-data"> <td class="product-data-label font-weight-bold p-3 align-top text-md-right w-25">Species</td> <td class="product-data-value p-3 px-4 text-break"> Human </td> </tr> <tr class="product-data"> <td class="product-data-label font-weight-bold p-3 align-top text-md-right w-25">Source</td> <td class="product-data-value p-3 px-4 text-break"> N/A </td> </tr> </table> </div> <div id="scientific-data" class="nav-link px-0" data-anchor-label="Scientific Data"><table class="product-data-wrapper tablesaw tablesaw-stack table" id="data_image_table_wrapper"><h3>Scientific Data Examples for Human Mesenchymal Stem Cell Functional Identification Kit</h3><article class="product-data-wrapper"> <tr class="row m___product-data-examples"> <td class="border-0"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand=""> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/Human_Mesenchymal_Stem_Cell_Functional_Identification_Kit_SC006_Verification_of_Multipotency_ICC_Large.jpg" data-srcset="https://resources.bio-techne.com/images/products/Human_Mesenchymal_Stem_Cell_Functional_Identification_Kit_SC006_Verification_of_Multipotency_ICC_Large.jpg" alt="Verification of Multipotency using the Human Mesenchymal Stem Cell Functional Identification Kit. " title="Verification of Multipotency using the Human Mesenchymal Stem Cell Functional Identification Kit. " data-caption="Human mesenchymal stem cells were cultured in StemXVivo<sup>®</sup>Mesenchymal Stem Cell Expansion Media (Catalog # <a class="NoLineLink" href="/p/cell-culture/stemxvivo-mesenchymal-stem-cell-expansion-media_ccm004" target="_self">CCM004</a>) and differentiation was induced as indicated using the media supplements included in the Human Mesenchymal Stem Cell Functional Identification Kit (Catalog # SC006). The kit also contains a Goat Anti-Mouse FABP-4 Antigen Affinity-purified Polyclonal Antibody (adipocytes), a Goat Anti-Human Aggrecan Antigen Affinity-purified Polyclonal Antibody (chondrocytes), and a Mouse Anti-Human Osteocalcin Monoclonal Antibody (osteocytes) for the confirmation of differentiation status. The cells were stained using the NorthernLightsTM 557-conjugated Donkey Anti-Goat (Catalog # <a class="NoLineLink" href="/p/secondary-antibodies/goat-igg-northernlights-nl557-conjugated-antibody_nl001" target="_self">NL001</a>; red) or Anti-Mouse (Catalog # <a class="NoLineLink" href="/p/secondary-antibodies/mouse-igg-northernlights-nl557-conjugated-antibody_nl007" target="_self">NL007</a>; red) IgG Secondary Antibodies, and the nuclei were counterstained with DAPI (blue)." data-badges="" data-application="Cell Proliferation" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </td> <td class="w-75 border-0 align-top"> <p> <strong>Verification of Multipotency using the Human Mesenchymal Stem Cell Functional Identification Kit. </strong> Human mesenchymal stem cells were cultured in StemXVivo<sup>®</sup>Mesenchymal Stem Cell Expansion Media (Catalog # <a href="/p/cell-culture/stemxvivo-mesenchymal-stem-cell-expansion-media_ccm004" target="_self">CCM004</a>) and differentiation was induced as indicated using the media supplements included in the Human Mesenchymal Stem Cell Functional Identification Kit (Catalog # SC006). The kit also contains a Goat Anti-Mouse FABP-4 Antigen Affinity-purified Polyclonal Antibody (adipocytes), a Goat Anti-Human Aggrecan Antigen Affinity-purified Polyclonal Antibody (chondrocytes), and a Mouse Anti-Human Osteocalcin Monoclonal Antibody (osteocytes) for the confirmation of differentiation status. The cells were stained using the NorthernLightsTM 557-conjugated Donkey Anti-Goat (Catalog # <a href="/p/secondary-antibodies/goat-igg-northernlights-nl557-conjugated-antibody_nl001" target="_self">NL001</a>; red) or Anti-Mouse (Catalog # <a href="/p/secondary-antibodies/mouse-igg-northernlights-nl557-conjugated-antibody_nl007" target="_self">NL007</a>; red) IgG Secondary Antibodies, and the nuclei were counterstained with DAPI (blue). </p> </td> </tr> </article> </table> </div> <div id="preparation--storage" class="nav-link px-0" data-anchor-label="Preparation & Storage"><div id="cc_prep_storage"><h3>Preparation & Storage</h3><table class="table-bordered table" id="prep_storage_wrapper"><tr class="product-data"> <td class="product-data-label font-weight-bold p-3 align-top text-md-right w-25">Shipping Conditions</td> <td class="product-data-value p-3 px-4 text-break"> The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below. </td> </tr> <tr class="product-data"> <td class="product-data-label font-weight-bold p-3 align-top text-md-right w-25">Storage</td> <td class="product-data-value p-3 px-4 text-break"> Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date. </td> </tr> </table> </div> </div> <div id="product-datasheets-anchor" class="nav-link static-anchor p-0" data-anchor-label="Product Datasheets"></div> </div> </div> <div class="tab-pane fade mx-4 py-4 show" id="procedure-tab" data-tab-label="Procedure" role="tabpanel" aria-labelledby="procedure-tab-tab"><div id="cell_culture_assay_procedure"><h3>Assay Procedure</h3><article class="product-data-wrapper"> <html><head><style type="text/css">.psp-procedure {margin:20px 0; clear:both; border-top:1px solid #efefef;} .psp-procedure > div {float:left; width:48%; padding:5px;} .psp-step .clear {clear:both;} </style> </head><body><p><strong>Refer to the product <a href="//resources.rndsystems.com/pdfs/datasheets/SC006.pdf" target="_blank" class="a___link-external">datasheet</a> for complete product details.</strong></p> <div class="grid_7"> <p>Briefly, human MSC multipotency is verified using the following in vitro differentiation procedure:</p> <ul> <li>Culture multipotent cells of interest</li> <li>Induce adipocyte, chondrocyte, and osteocyte differentiation using media supplements</li> <li>Evaluate differentiation using mature phenotype marker antibodies and fluorescent ICC</li> </ul> </div> <div class="grid_4 text_center"><a href="//resources.rndsystems.com/images/site/sc006-protocol-overlay.png" target="_blank" title="View SC006 Protocol Graphic Summary" class="a___link-external"><img alt="SC006 Protocol Graphic Summary" src="https://resources.rndsystems.com/images/site/sc006-protocol-tn.png" width="232"><br> View Graphic Procedure</a></div> <div class="clear"> </div> <p> </p> <h3 class="ds_lightBlueBar">Reagents Provided</h3> <h4>Reagents supplied in the Human Mesenchymal Stem Cell Functional Identification Kit (Catalog # SC006):</h4> <ul> <li>Adipogenic Supplement</li> <li>Chondrogenic Supplement</li> <li>Osteogenic Supplement</li> <li>ITS Supplement</li> <li><em>Adipocyte marker:</em> Goat Anti-Mouse FABP4 Antigen-affinity Purified Polyclonal Antibody</li> <li><em>Chondrocyte marker:</em> Goat Anti-Human Aggrecan Antigen-affinity Purified Polyclonal Antibody</li> <li><em>Osteocyte marker:</em> Mouse Anti-Human Osteocalcin Antigen-affinity Purified Monoclonal Antibody</li> </ul> <p><strong>Note:</strong> <em>The quantity of each media supplement in this kit is sufficient to make 50 mL of media for differentiation. 50 mL can be used for 16 wells of a 24-well plate for osteogenic and adipogenic lineages and 10 chondrocyte pellets.</em></p> <p> </p> <h3 class="ds_lightBlueBar">Other Supplies Required</h3> <h4>Reagents</h4> <ul> <li>StemXVivo<sup>®</sup> Osteogenic/Adipogenic Base Media (Catalog # <a href="/p/cell-culture/stemxvivo-osteogenic-adipogenic-base-media_ccm007">CCM007</a> or equivalent)</li> <li>D-MEM/F-12 (1X)</li> <li>Phosphate Buffered Saline (PBS)</li> <li>Penicillin-Streptomycin-Glutamate (100X)</li> <li>4% Paraformaldehyde in PBS</li> <li>1% BSA in PBS</li> <li>Triton<sup>®</sup> X-100</li> <li>10% normal donkey serum</li> <li>Fibronectin (optional; Human Fibronectin, Catalog # <a href="/p/proteins-enzymes/human-fibronectin-protein-cf_1918-fn">1918-FN</a>, Bovine Fibronectin, Catalog # <a href="/p/proteins-enzymes/bovine-fibronectin-protein-cf_1030-fn">1030-FN</a>, or equivalent)</li> <li>Mounting medium (Catalog # <a href="/p/staining-kits-reagents/mounting-medium_cts011">CTS011</a> or equivalent)</li> <li>NorthernLightsTM 557-conjugated Donkey Anti-Goat IgG Secondary Antibody (Catalog # <a href="/p/secondary-antibodies/goat-igg-northernlights-nl557-conjugated-antibody_nl001">NL001</a> or equivalent)</li> <li>Deionized or distilled water</li> </ul> <h4>Materials</h4> <ul> <li>Human MSCs</li> <li>24-well culture plates</li> <li>12 mm coverslips (Carolina Biologicals, Catalog # 633009 or equivalent)</li> <li>15 mL centrifuge tubes</li> <li>Pipettes and pipette tips</li> <li>Serological pipettes</li> <li>Glass slides</li> <li>Fine pointed curved forceps</li> <li>Liquid barrier pen</li> </ul> <h4>Equipment</h4> <ul> <li>37 <sup>°</sup>C and 5% CO<sub>2</sub> incubator</li> <li>Centrifuge</li> <li>Hemocytometer</li> <li>Inverted microscope</li> <li>2 <sup>°</sup>C to 8 <sup>°</sup>C refrigerator</li> <li>37 <sup>°</sup>C water bath</li> <li>Fluorescence microscope</li> <li>Cryostat</li> </ul> <div class="clear"> </div> <h3 class="ds_lightBlueBar">Procedure Overview</h3> <p>This protocol has been tested using bone marrow- and/or adipose tissue-derived MSCs. If using a different tissue source or cell line, the protocol below may need to be optimized.</p> <h4><strong>Adipogenic Differentiation</strong></h4> <div class="psp-procedure"> <div class="psp-step"> <p><strong>Plate</strong> 2.1 x 10<sup>4</sup> MSCs/cm<sup>2</sup> in StemXVivo<sup>®</sup> Osteogenic/Adipogenic Base Media.</p> <p><strong>Culture</strong> cells to 100% confluency.</p> </div> <div><img alt="Culture cells to 100% confluency." src="//resources.rndsystems.com/images/site/sc006-protocol-adipoandosteo-step1.png"></div> </div> <div class="psp-procedure"> <div class="psp-step"> <p><strong>Replace</strong> the medium with Adipogenic Differentiation Medium to induce adipogenesis.</p> </div> <div><img alt="Replace the medium with Adipogenic Differentiation Medium to induce adipogenesis." src="//resources.rndsystems.com/images/site/sc006-protocol-adipo-step2.png"></div> </div> <div class="psp-procedure"> <div class="psp-step"> <p><strong>Every 2-3 days</strong>, replace with fresh Adipogenic Differentiation Medium.</p> <p><strong>After 14-21 days</strong>, adipocytes can be fixed.</p> </div> <div> </div> </div> <div class="psp-procedure"> <div class="psp-step"> <p><strong>ICC detection</strong> of FABP4.</p> </div> <div><img alt="ICC detection of FABP4." src="//resources.rndsystems.com/images/site/sc006-protocol-adipo-step3.png"></div> </div> <div class="psp-procedure"> <div class="psp-step"> <h4><strong>Osteogenic Differentiation</strong></h4> </div> <div> </div> </div> <div class="psp-procedure"> <div class="psp-step"> <p><strong>Plate</strong> 4.2 x 10<sup>3</sup> MSCs/cm<sup>2</sup> in StemXVivo<sup>®</sup> Osteogenic/Adipogenic Base Media.</p> <p><strong>Culture</strong> cells to 50-70% confluency.</p> </div> <div><img alt="Plate 4.2 x 103 MSCs/cm 2 in StemXVivo Osteogenic/Adipogenic Base Media. " src="//resources.rndsystems.com/images/site/sc006-protocol-adipoandosteo-step1.png"></div> </div> <div class="psp-procedure"> <div class="psp-step"> <p><strong>Replace</strong> the medium with Osteogenic Differentiation Medium to induce osteogenesis.</p> </div> <div><img alt="Replace the medium with Osteogenic Differentiation Medium to induce osteogenesis." src="//resources.rndsystems.com/images/site/sc006-protocol-chondro-step2.png"></div> </div> <div class="psp-procedure"> <div class="psp-step"> <p><strong>Every 3-4 days</strong>, replace with fresh Osteogenic Differentiation Medium.</p> <p><strong>After 14-21 days</strong>, osteocytes can be fixed.</p> </div> <div> </div> </div> <div class="psp-procedure"> <div class="psp-step"> <p><strong>ICC detection</strong> of Osteocalcin.</p> </div> <div><img alt="ICC detection of Osteocalcin." src="//resources.rndsystems.com/images/site/sc006-protocol-osteo-step3.png"></div> </div> <div class="psp-procedure"> <div class="psp-step"> <h4><strong>Chondrogenic Differentiation</strong></h4> </div> <div> </div> </div> <div class="psp-procedure"> <div class="psp-step"> <p><strong>Transfer</strong> 2.5 x 10<sup>4</sup> MSCs to a 15 mL conical tube.</p> <p><strong>Centrifuge</strong> and <strong>resuspend</strong> the cells in Chondrogenic Differentiation Media.</p> <p><strong>Centrifuge</strong> the cells but do not remove the medium.</p> </div> <div><img alt="Transfer 2.5 x 104 MSCs to a 15 mL conical tube." src="//resources.rndsystems.com/images/site/sc006-protocol-chondro-step1.png"></div> </div> <div class="psp-procedure"> <div class="psp-step"> <p><strong>Every 2-3 days</strong>, replace with fresh Chondrogenic Differentiation Media.</p> <p><strong>After 14-21 days</strong>, the chondrogenic pellet can be fixed.</p> </div> <div><img alt="Every 2-3 days, replace with fresh Chondrogenic Differentiation Media." src="//resources.rndsystems.com/images/site/sc006-protocol-chondro-step2.png"></div> </div> <div class="psp-procedure"> <div class="psp-step"> <p><strong>Cryosection</strong> the chondrogenic pellet.</p> </div> <div> </div> </div> <div class="psp-procedure"> <div class="psp-step"> <p><strong>ICC detection</strong> of Aggrecan.</p> </div> <div><img alt="ICC detection of Aggrecan." src="//resources.rndsystems.com/images/site/sc006-protocol-chondro-step3.png"></div> </div></body></html> </article> </div> </div> <div class="tab-pane fade mx-4 py-4 show" id="citations-reviews-faqs-tab" data-tab-label="Citations / Reviews (1) / FAQs" role="tabpanel" aria-labelledby="citations-reviews-faqs-tab-tab"><div class="product_details_anchors mb-2"> <div class="nav mx-0 pt-4 pb-2 m___nav-anchors d-none d-lg-flex"> <li class="nav-item m-0"> <a class="nav-link jump-anchor active" href="#citations"> Citations </a> </li> <li class="nav-item m-0"> <a class="nav-link jump-anchor active" href="#reviews"> Reviews </a> </li> <li class="nav-item m-0"> <a class="nav-link jump-anchor active" href="#faqs"> 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Human Mesenchymal Stem Cell Functional Identification Kit (SC006) by R&D Systems, Part of Bio-Techne