CINXE.COM

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id="content_column"> <div class="ds_title_table"> <h1 class="ds_title">Recombinant Human 5'-Nucleotidase/CD73 Fc Avi-tag, CF </h1> <div class="dsSprite_rnd ds_brand_logo ds_rnd_logo"></div> </div> <div class="product_meta"> <span class="category_number">Catalog #: AVI11377</span> <a href="/reviews/AVI11377" rel="nofollow"><span class="submit_review"><button class="btn btn-quaternary">Submit a Review</button></span></a> <span class="datasheet_link"> <a href="#product-datasheets">Datasheet / COA / SDS</a> </span> </div> <div class="product_info">Fc Chimera</div>  <div class="product_wrapper row"> <div class="product_ordering_wrapper col-xs-12 col-md-8 col-md-push-4"> <div class="product_ordering"> <form action="/products/recombinant-human-5-nucleotidase-cd73-fc-avi-tag-cf_avi11377" method="post" id="atc-datasheet-form" accept-charset="UTF-8"><div><div id="atc_datasheet_block">     <table class="add_to_cart"> <thead> <tr> <th class="ds_catalog">Catalog #</th> <th 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Up to 30% off + FREE shipping. <a href="/promotions#reagents25" target="_blank">See Details</a>.</p> </div> <div class="ds_atc_pre_buttons"></div> <div class="ds_atc_buttons"> <a href="/quote/instruments/ella-automated-immunoassay-system" class="btn btn-secondary atc_request_quote_simple_plex_assay" style="display:none" rel="nofollow">Request a Quote</a> <a href="/services/bulk-quote-request?catnum=AVI11377&product=Recombinant Human 5'-Nucleotidase/CD73 Fc Avi-tag, CF" class="btn btn-secondary atc_hidden bulk_btn" style="display:none;" rel="nofollow" title="Competitive discounts on products purchased in bulk quantities">Bulk Orders</a> <button class="btn btn-primary atc_hidden atc_btn form-submit icon-before" style="display:none;" title="Enter quantities above and click to add to cart" type="submit" id="edit-add-to-cart" name="add_to_cart_btn" value="Add to Cart"><span class="icon glyphicon glyphicon-plus" aria-hidden="true"></span> Add to Cart</button> </div> <div class="ds_atc_post_buttons"></div> </div> <input type="hidden" name="form_build_id" value="form-cziVhoeLigEwvhzWAFk-vbfJ41n49pTh6jNDaciG9Jk" /> <input type="hidden" name="form_id" value="atc_datasheet_form" /> </div></form> </div> </div> <div class="product_image_wrapper col-xs-12 col-md-4 col-md-pull-8"> <div class="product_image"> <span class="product_image_label"> </span> <a class="ds-image overview-images" data-toggle="lightbox" data-gallery="overview-images" onClick="event.preventDefault();" data-title="Biotinylated Recombinant Human 5'‑Nucleotidase/CD73 Fc Chimera Avi-tag Protein Binding Activity." data-footer="Biotinylated Recombinant Human 5'‑Nucleotidase/CD73 Fc Chimera Avi-tag Protein Binding Activity." title="Cat. No. AVI11377 - Recombinant Human 5'-Nucleotidase/CD73 Fc Avi-tag, CF" href="https://resources.rndsystems.com/images/datasheets/avi11377_recombinant-human-5-nucleotidase-cd73-fc-avi-tag-cf-binding-activity-1492023101649..jpg"> <img fetchpriority="high" src="https://resources.rndsystems.com/images/datasheets/avi11377_recombinant-human-5-nucleotidase-cd73-fc-avi-tag-cf-binding-activity-1492023101649..jpg" class="img-fluid" alt="Biotinylated Recombinant Human 5'‑Nucleotidase/CD73 Fc Chimera Avi-tag Protein Binding Activity." title="Biotinylated Recombinant Human 5'‑Nucleotidase/CD73 Fc Chimera Avi-tag Protein Binding Activity."> </a> <div class="search_image_other_count"> <span class="search_more_images">1 Image</span> </div> </div> </div> <div id="extra_images overview-images" class="hidden"> </div> </div> <div class="product_info_wrapper"> </div> <div id="view-more-target" class="datasheet_section_element"> <a href="/target/5-nucleotidase-cd73?category=Proteins and Enzymes" class="btn btn-secondary">All 5'-Nucleotidase/CD73 Proteins and Enzymes</a> </div> </div> <div class="tabbed_content" id="rnd_protein"> <div id="ds_tabs" class="tab_menu"> <div class="tab tab_1 tab_open" data-tab="1" data-tabname="product-details" id="dsTabs_product-details"> <span>Product Details</span> </div> <div class="tab tab_4" data-tab="4" data-tabname="faqs" id="dsTabs_faqs"> <span>FAQs</span> </div> <div class="tab tab_5" data-tab="5" data-tabname="supplemental-products" id="dsTabs_supplemental-products"> <span>Supplemental Products</span> </div> <div class="tab tab_6" data-tab="6" data-tabname="product-reviews" id="dsTabs_product-reviews"> <span> Reviews </span> </div> </div> <div class="tab_content tab_1 tab_open" data-tab="1" data-tabname="product-details" id="product-details"> <div class="datasheet_section_element"> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_summary" id="product-anchor-ds_summary">Summary</a> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_datasheets" id="product-anchor-ds_datasheets">Product Datasheets</a> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_carrier_free" id="product-anchor-ds_carrier_free">Carrier Free</a> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_data_examples" id="product-anchor-ds_data_examples">Data Images</a> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_calculator" id="product-anchor-ds_calculator">Reconstitution Calculator</a> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_background" id="product-anchor-ds_background">Background</a> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_related_research_areas" id="product-anchor-ds_related_research_areas">Related Research Areas</a> </div> <div id="ds_summary" class="datasheet_section"> <h2>Recombinant Human 5'-Nucleotidase/CD73 Fc Avi-tag, CF Summary</h2> <div class="what-statement-container"> </div> <div class="why-statement-container"> </div> <h4 class="mt-3">Product Specifications</h4> <div class="ds_table summary_table"> <div class="ds_table_body"> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Purity</div> <div class="ds_table_cell summary_table_data">>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.</div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Endotoxin Level</div> <div class="ds_table_cell summary_table_data"><1.0 EU per 1 μg of the protein by the LAL method.</div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Activity</div> <div class="ds_table_cell summary_table_data">Measured by its ability to hydrolyze the 5’-phosphate group from the substrate adenosine-5’-monophosphate (AMP). The orthophosphate product is measured by a Malachite Green Phosphate Detection Kit (Catalog # <a class=NoLineLink href='http://www.rndsystems.com/product_results.aspx?k=DY996'>DY996</a>). The specific activity is >5500 pmol/min/μg, as measured under the described conditions. Measured by its binding ability in a functional ELISA. Biotinylated Recombinant Human 5'-Nucleotidase/CD73 Fc Chimera Avi-tag (Catalog # AVI11377) binds Human/Equine 5'-Nucleotidase/CD73 Antibody (Catalog # <a class="NoLineLink" href="http://www.rndsystems.com/product_results.aspx?k=MAB5795">MAB5795</a>) with an ED<sub>50</sub> of 3.00-30.0 ng/mL.</div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Source</div> <div class="ds_table_cell summary_table_data">Human embryonic kidney cell, HEK293-derived human 5'-Nucleotidase/CD73 protein<br /><table><tbody><tr><td class="TableText7" style="BORDER-RIGHT: black 1pt solid; BORDER-TOP: black 1pt solid; BORDER-LEFT: black 1pt solid; WIDTH: 192px; BORDER-BOTTOM: black 1pt solid" align="middle">Human 5'-Nucleotidase/CD73<br style="font-family: sans-serif;">(Trp27-Lys547)<br style="font-family: sans-serif;">Accession # AAH65937.1</td><td class="TableText7" style="BORDER-RIGHT: black 1pt solid; BORDER-TOP: black 1pt solid; BORDER-LEFT: black 1pt solid; WIDTH: 192px; BORDER-BOTTOM: black 1pt solid" align="middle">GGIEGRMD</td><td class="TableText7" style="BORDER-RIGHT: black 1pt solid; BORDER-TOP: black 1pt solid; BORDER-LEFT: black 1pt solid; WIDTH: 192px; BORDER-BOTTOM: black 1pt solid" align="middle">Human IgG<sub style="font-family: sans-serif;">1</sub><br style="font-family: sans-serif;">(Pro100-Lys330)</td><td class="TableText7" style="BORDER-RIGHT: black 1pt solid; BORDER-TOP: black 1pt solid; BORDER-LEFT: black 1pt solid; WIDTH: 192px; BORDER-BOTTOM: black 1pt solid" align="middle">Avi-tag</td></tr><tr><td class="TableText7" style="BORDER-LEFT: black 0pt solid; WIDTH: 192px" align="left">N-terminus</td><td class="TableText7" style="BORDER-RIGHT: black 0pt solid; WIDTH: 192px" align="left"></td><td class="TableText7" style="BORDER-RIGHT: black 0pt solid; WIDTH: 192px" align="left"></td><td class="TableText7" style="BORDER-RIGHT: black 0pt solid; WIDTH: 192px" align="right">C-terminus </td></tr><tr></tr></tbody></table></div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Accession #</div> <div class="ds_table_cell summary_table_data"><a href="http://www.ncbi.nlm.nih.gov/protein/AAH65937.1" target="_blank" rel="noreferrer nofollow">AAH65937.1</a></div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">N-terminal Sequence<br />Analysis</div> <div class="ds_table_cell summary_table_data">Trp27</div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Structure / Form</div> <div class="ds_table_cell summary_table_data">Biotinylated via Avi-tag</div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Predicted Molecular Mass</div> <div class="ds_table_cell summary_table_data">86 kDa</div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">SDS-PAGE</div> <div class="ds_table_cell summary_table_data">88-98 kDa, under reducing conditions</div> </div> </div> </div> </div> <div id="customer_also_purchased_block" class="loader" data-catalogId="AVI11377"></div> <div class="datasheet_section" id="product-datasheets"> <h2 id="ds_datasheets">Product Datasheets</h2> <div class="product_datasheets"> <span class="sds-message hide"> <p class="sds-label">You must select a language.</p> <span class="close_sds_message">x</span> </span> <h2>AVI11377 </h2> <div class="ds_document"> <a id="cfpdf" href="//resources.rndsystems.com/pdfs/datasheets/avi11377.pdf?v=20250207" class="datasheets-link " target="_blank" rel="noreferrer nofollow">Product Datasheet</a> </div> <div class="ds_document"> <div class="ds_pdfData"><a class="datasheets-link" href="https://www.rndsystems.com/cofas/recombinant-human-5-nucleotidase-cd73-fc-avi-tag-cf_avi11377">COA</a> </div> </div> <div class="ds_document sds_link"> <a class="sds_non_cf datasheets-link non_cf_download_link" target="_blank" rel="noreferrer" data-path="//aero.bio-techne.com/sds/pdf/avi11377?v=20250207">SDS</a> </div> </div> </div> <div id="ds_carrier_free" class="datasheet_section"> <h2>Carrier Free</h2> <div class="highlight">What does CF mean?</div> <p>CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA. </p> <div class="highlight">What formulation is right for me?</div> <p>In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere. </p> <div class="cf_tables row"> <div class="cf_table_1 col-xs-12"> <h4 class="cf_table_name">AVI11377</h4> <table class="ds_table_html carrier_free_table"> <tbody> <tr> <td class="cf_key_name">Formulation</td> <td>Supplied as a 0.2 μm filtered solution in Tris, NaCl, CaCl<sub>2</sub> and Glycerol.</td> </tr> <tr> <td class="cf_key_name">Shipping</td> <td>The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.</td> </tr> <tr> <td class="cf_key_name">Stability & Storage:</td> <td><b>Use a manual defrost freezer and avoid repeated freeze-thaw cycles.</b><UL><LI>6 months from date of receipt, -20 to -70 °C as supplied.</LI><LI>3 months, -20 to -70 °C under sterile conditions after opening.</LI></UL></td> </tr> </tbody> </table> </div> </div> </div> <div id="pd_assay_procedure" class="datasheet_section"> <h2>Assay Procedure</h2> <div><strong>Materials</strong></div> <div><div><ul><li>Assay Buffer:  25 mM Tris, 5 mM MgCl<sub>2</sub>, pH 7.5</li><li>Biotinylated Recombinant Human 5'‑Nucleotidase/CD73 Fc Chimera Avi-tag (rhCD73/Fc) (Catalog # AVI11397)</li><li>Substrate: Adenosine monophosphate (AMP), 5 mM stock in deionized water</li><li>Malachite Green Phosphate Detection Kit (Catalog # <a class="NoLineLink" href="http://www.rndsystems.com/product_results.aspx?k=DY996">DY996</a>)</li><li>96-well Clear Plate (Catalog # <a class="NoLineLink" href="http://www.rndsystems.com/product_results.aspx?k=DY990">DY990</a>)</li><li>Plate Reader with Absorbance Read Capability</li></ul></div> <div><ol><li>Prepare a standard curve from the 1 M Phosphate Standard by adding 10 µL of the 1 M Phosphate Standard to 990 µL of Assay Buffer for a 10 mM stock. Continue by adding 10 µL of the 10 mM Phosphate stock to 990 µL of Assay Buffer for a 100 µM stock (this is the first dilution to use as a standard).</li><li>Perform six additional one-half serial dilutions of the 100 µM Phosphate stock using Assay Buffer. The standard curve has a range of 0.078 to 5 nmol per well.</li><li>Dilute rhCD73/Fc to 0.16 µg/mL in Assay Buffer.</li><li>Dilute AMP to 100 µM in Assay Buffer.</li><li>Load 50 µL of each dilution of the standard curve into a plate. Include a curve blank containing 50 μL of Assay Buffer.</li><li>Load 25 µL of 0.16 µg/mL rhCD73/Fc into empty wells of the same plate as the curve. Include a Control containing 25 μL of Assay Buffer.</li><li>Start the reactions by adding 25 µL of 100 µM AMP to all wells, excluding the standard curve and curve blank.  </li><li>Seal plate and incubate at 37 °C for 20 minutes.</li><li>Add 30 µL of the Malachite Green Reagent A to all wells used, including standard curve. Mix briefly.</li><li>Add 100 µL of deionized water to all wells used, including standard curve. Mix briefly.</li><li>Add 30 µL of the Malachite Green Reagent B to all wells used, including standard curve. Mix briefly.</li><li>Seal plate and incubate at room temperature for 20 minutes.</li><li>Read plate at 620 nm (absorbance) in endpoint mode.</li><li>Calculate specific activity:</li></ol></div><div><table><tbody><tr><td align="right" rowspan="2"><p>     Specific Activity (pmol/min/µg) =</p></td><td align="middle" style="padding-bottom: 2px; border-bottom: 1pt solid black;">Phosphate released* (nmol) x (1000 pmol/nmol)</td></tr><tr><td align="middle" style="border-bottom: 0pt solid black;">Incubation time (min) x amount of enzyme (µg)</td></tr></tbody></table><p>     </p></div><div>*Derived from the phosphate standard curve using linear or 4-parameter fitting and adjusted for Control.</div> <div>Per Reaction:</div><div><ul><li>rhCD73/Fc: 0.004 µg </li><li>Substrate: 50 µM</li></ul></div></div> </div> <div id="ds_scientific_data" class="datasheet_section"> <div id="ds_data_examples"> <h2>Scientific Data</h2> <div id="data_examples"> <div class="row data_ex_row"> <a id="ds_image_0" class="pageAnchor"></a> <div class="data_ex_image_wrapper col-xs-12 col-sm-5 col-md-4"> <div class="data_ex_image"> <span class="data_ex_image_label"> Binding Activity </span> <a class="ds-image overview-images data_ex_image_link" data-toggle="lightbox" data-gallery="overview-images-0" data-title="Biotinylated Recombinant Human 5'‑Nucleotidase/CD73 Fc Chimera Avi-tag Protein Binding Activity." data-footer="" title="Cat. No. - " href="https://resources.rndsystems.com/images/datasheets/avi11377_recombinant-human-5-nucleotidase-cd73-fc-avi-tag-cf-binding-activity-1492023101649..jpg"> <img loading="lazy" src="https://resources.rndsystems.com/images/datasheets/avi11377_recombinant-human-5-nucleotidase-cd73-fc-avi-tag-cf-binding-activity-1492023101649..jpg" class="img-fluid" alt="" title=""> <span class="data_ex_image_larger">View Larger</span> </a> </div> </div> <div class="data_ex_description col-xs-12 col-sm-7 col-md-8"> <p> Biotinylated Recombinant Human 5'-Nucleotidase/CD73 Fc Chimera Avi-tag Protein (Catalog # AVI11377) binds Human/Equine 5'-Nucleotidase/CD73 Antibody (<a class="NoLineLink" href="https://www.rndsystems.com/products/human-equine-5-nucleotidase-cd73-antibody-606112_mab5795">MAB5795</a>) with an ED<sub>50</sub> of 3.00-30.0 ng/mL. </p> </div> </div> </div> </div> </div> <div id="ds_calculator" class="datasheet_section"> <div id="btn_calculator_wrapper"><div class="datasheet_calculator_toggle btn btn-secondary" id="btn_reconstitution">Reconstitution Calculator</div></div><div id="datasheet_calculators"><div id="btn_reconstitution_calc" class="datasheet_calculator"><h2>Reconstitution Calculator</h2><div id="reconstitution_calculator" class="calculator"> <form id="recCalc"> <div class="reconstitution_calculator_text" id="reconstitution_calculator_instructions"> <p>The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.</p> </div> <div class="calc_section"> <label for="reconstitution_calculator_volume" class="calculator_label">Volume (to add to vial)</label> <input id="reconstitution_calculator_volume" name="reconstitution_calculator_volume" type="text" maxlength="16" placeholder="volume" class="calculator_input calculator_text"/> <span class="select_wrapper"> <select id="reconstitution_calculator_volume_unit" class="calculator_input calculator_select"> <option value="ml">ml</option> <option value="ul" selected="selected">ul</option> </select> </span> </div> <span class="calculator_equals calculator_operator">=</span> <div class="calc_section"> <label for="reconstitution_calculator_mass" class="calculator_label">Mass (in vial)</label> <input id="reconstitution_calculator_mass" name="reconstitution_calculator_mass" type="text" maxlength="16" placeholder="mass" class="calculator_input calculator_text"/> <span class="select_wrapper"> <select id="reconstitution_calculator_mass_unit" class="calculator_input calculator_select"> <option value="mg">mg</option> <option value="ug" selected="selected">ug</option> <option value="ng">ng</option> </select> </span> </div> <span class="calculator_divide calculator_operator">÷</span> <div class="calc_section"> <label for="reconstitution_calculator_concentration" class="calculator_label">Desired Reconstitution Concentration</label> <input id="reconstitution_calculator_concentration" name="reconstitution_calculator_concentration" type="text" maxlength="16" placeholder="conc." class="calculator_input calculator_text"/> <span class="select_wrapper"> <select id="reconstitution_calculator_concentration_unit" class="calculator_input calculator_select"> <option value="mg/ml">mg/ml</option> <option value="ug/ml" selected="selected">ug/ml</option> <option value="ng/ml">ng/ml</option> </select> </span> </div> <div id="reconstitution_foot" class="calc_section"> <input type="submit" value="Calculate" id="button_reconstitution_calculator_calculate" class="calculator_button btn btn-secondary"/> </div> </form> </div> </div></div> </div> <div id="ds_background" class="datasheet_section"> <h2>Background: 5'-Nucleotidase/CD73</h2> <p>CD73, known as ecto-5'-Nucleotidase, converts extracellular nucleoside 5' monophosphates to nucleosides, with AMP as its preferred substrate (1). CD73 is a zinc-dependent, homodimeric enzyme bound to the cell membrane through a glycosyl phosphatidylinositol (GPI) anchor. It is composed of an N-terminal domain containing metal binding sites linked via small hinge region to a C-terminal domain containing the substrate binding site and dimerization interface (2). It is expressed by most cell types (3) and is widely expressed in tumor cell lines as well as upregulated in cancerous tissues (4, 5). CD73 is a key enzyme responsible for a rate-limiting step in the generation of extracellular adenosine. Adenosine is a molecule that signals through activation of purinergic receptors and results in an immunosuppressive role in the tumor microenvironment (4, 6). CD73 has been implicated in many pathological processes including immunomodulation and inflammation (7,8) tumor growth and metastasis (9-13) making CD73 a potential drug target in cancer. Targeting CD73 inhibition has resulted in numerous reports of favorable antitumor effects (4, 5, 12). Consequently, therapeutic approaches have been tested using knockdown, gene silencing and anti-CD73 therapies (11, 14) as well as small molecule inhibitors (14, 15).</p> <div class="ds_table background_table"> <div class="ds_table_body"> <div class="ds_table_row"> <div class="ds_table_cell background_table_name"><a id="reftop"></a>References</div> <div class="ds_table_cell background_table_data"><div><ol><li>Zimmermann, H. <i>et. al.</i> (2012) Purinergic Signal. <b>8</b>:437.</li><li>Knapp, K. <i>et. al.</i> (2012) Structure. <b>20</b>:2161.</li><li>Resta, R. <i>et. al.</i> (1998) Immunol. Rev. <b>161</b>:95. </li><li>Jin, D. <i>et. al. </i>(2010) Cancer Res. <b>70</b>:2245.</li><li>Zhang, B. (2010) Cancer Res. <b>70</b>:6407.</li><li>Picher, M. <i>et. al.</i> (2003) J. Biol. Chem. <b>278</b>:13468. </li><li>Antonioli, L. <i>et. al.</i> (2012) Curr. Drug Targets <b>13</b>:842.</li><li>Eltzchig, H.K. <i>et. al.</i> (2012) N. Engl. J. Med. <b>367</b>:2322.</li><li>Bavaresco, L. <i>et. al.</i> (2008) Mol. Cell Biochem. <b>319</b>:61.</li><li>Yegutkin, G.G. <i>et. al.</i> (2011) Eur. J. Immunol. <b>41</b>:1231.</li><li>Stagg, J. <i>et. al.</i> (2012) Cancer Res. <b>72</b>:2190.</li><li>Ghalamfarsa, G. <i>et. al.</i> (2019) Expert Opin. Ther. Targets. <b>23</b>:127.</li><li>Gao, Z.W. <i>et. al. </i>(2014) Biomed. Res. Int.<b> 2014</b>:460654.</li><li>Young, A. <i>et. al.</i> (2014) Cancer Discov.<b> 4</b>:879.</li><li>McManus, J. <i>et. al.</i> (2018) SLAS Discov. <b>23</b>:264.</li></ol></div></div> </div> <div class="ds_table_row"> <div class="ds_table_cell background_table_name">Entrez Gene IDs</div> <div class="ds_table_cell background_table_data">4907 (Human); 23959 (Mouse); 58813 (Rat); 102114976 (Cynomolgus Monkey)</div> </div> <div class="ds_table_row"> <div class="ds_table_cell background_table_name">Alternate Names</div> <div class="ds_table_cell background_table_data">5' nucleotidase (CD73); 5'-NT; 5-NT; 5'-Nucleotidase; 5'-nucleotidase, ecto (CD73); CD73 antigen; CD73; E5NT; EC 3.1.3.5; ecto-5'-nucleotidase; eN; eNT; NT; NT55'-nucleotidase; NT5E; NTE; Purine 5-Prime-Nucleotidase</div> </div> </div> </div> </div> <div id="ds_related_research_areas" class="datasheet_section"> <h2>Related Research Areas</h2> <ul class="ds_details"> <li> <a href="/research-area/acute-lymphoblastic-leukemia">Acute Lymphoblastic Leukemia</a> </li> <li> <a href="/research-area/mesenchymal-stem-cell-markers">Mesenchymal Stem Cell Markers</a> </li> <li> <a href="/research-area/osteoblast-and-osteoclast-markers">Osteoblast and Osteoclast Markers</a> </li> <li> <a href="/research-area/phosphatases-and-regulators">Phosphatases and Regulators</a> </li> <li> <a href="/research-area/regulatory-t-cells--tregs">Regulatory T Cells (Tregs)</a> </li> <li> <a href="/research-area/renal-markers">Renal Markers</a> </li> <li> <a href="/research-area/search-immunotherapy--related-enzymes">Search Immunotherapy-related Enzymes</a> </li> <li> <a href="/research-area/search-kinases-and-phosphatases">Search Kinases and Phosphatases</a> </li> </ul> </div> </div> <div class="tab_content tab_4" data-tab="4" data-tabname="product-faqs" id="product-faqs"> <h2>FAQs</h2> <div class="row"> <div class="col-xs-12"> <p>No product specific FAQs exist for this product, however you may</p> <a class="btn btn-quinary view_all_faqs_btn" href="/resources/faqs/proteins-and-enzymes"> View all Proteins and Enzyme FAQs </a> </div> </div> </div> <div class="tab_content tab_5" data-tab="5" data-tabname="product-supplemental" id="supplemental-products"> <div id="supplemental-products-tab-content-placeholder" class="tab-content-placeholder" data-id="supplemental-products" data-catalog_number="avi11377" data-language="en"> <div class="et_spinner_small"></div> Loading... </div> </div> <div class="tab_content tab_6" data-tab="6" data-tabname="product-reviews" id="reviews"> <h3>Reviews for Recombinant Human 5'-Nucleotidase/CD73 Fc Avi-tag, CF</h3> <div class="row"> <div class="col-xs-12"> <div> <div class="row"> <div class="col-md-6"> <p>There are currently no reviews for this product. 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