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style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="doctor and patient | Image Credit: © Halfpoint - stock.adobe.com" title="doctor and patient | Image Credit: © Halfpoint - stock.adobe.com" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F691ecebc9ecf2884c4a59c490d9e0a67cdbf995f-5388x3592.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=75 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F691ecebc9ecf2884c4a59c490d9e0a67cdbf995f-5388x3592.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=75 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F691ecebc9ecf2884c4a59c490d9e0a67cdbf995f-5388x3592.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=75 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F691ecebc9ecf2884c4a59c490d9e0a67cdbf995f-5388x3592.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=75 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F691ecebc9ecf2884c4a59c490d9e0a67cdbf995f-5388x3592.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=75 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F691ecebc9ecf2884c4a59c490d9e0a67cdbf995f-5388x3592.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=75 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F691ecebc9ecf2884c4a59c490d9e0a67cdbf995f-5388x3592.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F691ecebc9ecf2884c4a59c490d9e0a67cdbf995f-5388x3592.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F691ecebc9ecf2884c4a59c490d9e0a67cdbf995f-5388x3592.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="responsive" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="shrink-0" loading="lazy"/></noscript></span></div></div></a><div class="flex-auto w-auto sm:ml-8 flex-1"><span class="text-sm text-gray-500 italic sm:pl-4">November 20th 2024</span><p class="font-bold text-[1rem] sm:pl-4 text-undefined" style="font-size:1.125rem"><a href="/view/understanding-patient-perspectives-around-myasthenia-gravis-treatment-may-help-optimize-care">Understanding Patient Perspectives Around Myasthenia Gravis Treatment May Help Optimize Care</a></p><div class=" sm:pl-4"><a class="text-sm text-[#00ADEF] underline italic" href="/authors/karen-jacobson-sive">Karen Jacobson-Sive</a></div><a href="/view/understanding-patient-perspectives-around-myasthenia-gravis-treatment-may-help-optimize-care"><div class="mt-2 ml-4"></div><div class="flex flex-row gap-2"></div><p class=" text-sm text-gray-500 py-1 sm:pl-4">Patients with myasthenia gravis (MG) largely expressed negative emotions around MG treatment and symptom burden in patient focus groups and on MG social media discussion boards. </p><div class="pl-4"></div></a><div class="flex flex-col sm:flex-row pl-2 mt-4"></div></div></div></div></div></div><div class="w-full h-full"><hr class="mt-1 w-full " style="border-top-width:2px;border-top-color:#F3F4F6"/><div class="w-full h-full"><div class="flex flex-col sm:flex-row justify-center align-center w-100% "><div class="flex flex-col justify-center sm:flex-row py-4 " style="background-color:transparent;border-color:#F3F4F6;border-width:0;border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem"><a href="/view/poor-sleep-quality-associated-with-pulmonary-arterial-hypertension"><div class="sm:w-[288px] h-100% mt-2"><div class=""><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;padding-top:66.66666666666666%"></span><img alt="Patients with PAH may experience issues with sleep | image credit: princeoflove - stock.adobe.com" title="Patients with PAH may experience issues with sleep | image credit: princeoflove - stock.adobe.com" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="responsive" class="shrink-0" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="Patients with PAH may experience issues with sleep | image credit: princeoflove - stock.adobe.com" title="Patients with PAH may experience issues with sleep | image credit: princeoflove - stock.adobe.com" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fc64aba3fe6a6af601ec52548d146d692aca94792-6000x4000.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=75 640w, 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/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fc64aba3fe6a6af601ec52548d146d692aca94792-6000x4000.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fc64aba3fe6a6af601ec52548d146d692aca94792-6000x4000.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fc64aba3fe6a6af601ec52548d146d692aca94792-6000x4000.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="responsive" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="shrink-0" loading="lazy"/></noscript></span></div></div></a><div class="flex-auto w-auto sm:ml-8 flex-1"><span class="text-sm text-gray-500 italic sm:pl-4">November 14th 2024</span><p class="font-bold text-[1rem] sm:pl-4 text-undefined" style="font-size:1.125rem"><a href="/view/poor-sleep-quality-associated-with-pulmonary-arterial-hypertension">Poor Sleep Quality Associated With Pulmonary Arterial Hypertension </a></p><div class=" sm:pl-4"><a class="text-sm text-[#00ADEF] underline italic" href="/authors/karen-jacobson-sive">Karen Jacobson-Sive</a></div><a href="/view/poor-sleep-quality-associated-with-pulmonary-arterial-hypertension"><div class="mt-2 ml-4"></div><div class="flex flex-row gap-2"></div><p class=" text-sm text-gray-500 py-1 sm:pl-4">Most patients with pulmonary arterial hypertension (PAH) suffered from poor sleep quality, and dyspnea was a significant predictor of sleep quality, independent of disease severity, according to this study. </p><div class="pl-4"></div></a><div class="flex flex-col sm:flex-row pl-2 mt-4"></div></div></div></div></div></div><div class="w-full h-full"><hr class="mt-1 w-full " style="border-top-width:2px;border-top-color:#F3F4F6"/><div class="flex md:hidden justify-center items-center"></div><div class="w-full h-full"><div class="flex flex-col sm:flex-row justify-center align-center w-100% "><div class="flex flex-col justify-center sm:flex-row py-4 " style="background-color:transparent;border-color:#F3F4F6;border-width:0;border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem"><a href="/view/increased-surveillance-recommended-for-children-at-risk-for-hematopoietic-malignancy-predisposition"><div class="sm:w-[288px] h-100% mt-2"><div class=""><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;padding-top:52.75%"></span><img alt="Pediatrician test results tablet parent child | Image Credit: © nimito - stock.adobe.com" title="Pediatrician test results tablet parent child | Image Credit: © nimito - stock.adobe.com" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="responsive" class="shrink-0" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="Pediatrician test results tablet parent child | Image Credit: © nimito - stock.adobe.com" title="Pediatrician test results tablet parent child | Image Credit: © nimito - stock.adobe.com" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F5d76916c9fd2ced44e0d9a2b80ddff3abb308121-1200x633.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=75 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F5d76916c9fd2ced44e0d9a2b80ddff3abb308121-1200x633.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=75 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F5d76916c9fd2ced44e0d9a2b80ddff3abb308121-1200x633.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=75 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F5d76916c9fd2ced44e0d9a2b80ddff3abb308121-1200x633.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=75 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F5d76916c9fd2ced44e0d9a2b80ddff3abb308121-1200x633.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=75 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F5d76916c9fd2ced44e0d9a2b80ddff3abb308121-1200x633.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=75 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F5d76916c9fd2ced44e0d9a2b80ddff3abb308121-1200x633.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F5d76916c9fd2ced44e0d9a2b80ddff3abb308121-1200x633.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F5d76916c9fd2ced44e0d9a2b80ddff3abb308121-1200x633.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="responsive" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="shrink-0" loading="lazy"/></noscript></span></div></div></a><div class="flex-auto w-auto sm:ml-8 flex-1"><span class="text-sm text-gray-500 italic sm:pl-4">November 11th 2024</span><p class="font-bold text-[1rem] sm:pl-4 text-undefined" style="font-size:1.125rem"><a href="/view/increased-surveillance-recommended-for-children-at-risk-for-hematopoietic-malignancy-predisposition">Increased Surveillance Recommended for Children at Risk for Hematopoietic Malignancy Predisposition</a></p><div class=" sm:pl-4"><a class="text-sm text-[#00ADEF] underline italic" href="/authors/karen-jacobson-sive">Karen Jacobson-Sive</a></div><a href="/view/increased-surveillance-recommended-for-children-at-risk-for-hematopoietic-malignancy-predisposition"><div class="mt-2 ml-4"></div><div class="flex flex-row gap-2"></div><p class=" text-sm text-gray-500 py-1 sm:pl-4">Rigorous surveillance of children at high risk for developing myelodysplastic syndrome (MDS) is especially warranted, according to researchers.</p><div class="pl-4"></div></a><div class="flex flex-col sm:flex-row pl-2 mt-4"></div></div></div></div></div></div><div class="w-full h-full"><hr class="mt-1 w-full " style="border-top-width:2px;border-top-color:#F3F4F6"/><div class="w-full h-full"><div class="flex flex-col sm:flex-row justify-center align-center w-100% "><div class="flex flex-col justify-center sm:flex-row py-4 " style="background-color:transparent;border-color:#F3F4F6;border-width:0;border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem"><a href="/view/shared-decision-making-is-essential-prior-to-sma-enhancing-treatments"><div class="sm:w-[288px] h-100% mt-2"><div class=""><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;padding-top:56.043956043956044%"></span><img alt="Patients with SMA and their caregivers stand to benefit from shared decision-making processes | image credit: Intelligent Horizons - stock.adobe.com" title="Patients with SMA and their caregivers stand to benefit from shared decision-making processes | image credit: Intelligent Horizons - stock.adobe.com" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="responsive" class="shrink-0" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="Patients with SMA and their caregivers stand to benefit from shared decision-making processes | image credit: Intelligent Horizons - stock.adobe.com" title="Patients with SMA and their caregivers stand to benefit from shared decision-making processes | image credit: Intelligent Horizons - stock.adobe.com" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fc1d55c1da583552c0e48f503451a8d335189057a-8736x4896.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=75 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fc1d55c1da583552c0e48f503451a8d335189057a-8736x4896.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=75 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fc1d55c1da583552c0e48f503451a8d335189057a-8736x4896.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=75 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fc1d55c1da583552c0e48f503451a8d335189057a-8736x4896.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=75 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fc1d55c1da583552c0e48f503451a8d335189057a-8736x4896.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=75 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fc1d55c1da583552c0e48f503451a8d335189057a-8736x4896.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=75 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fc1d55c1da583552c0e48f503451a8d335189057a-8736x4896.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fc1d55c1da583552c0e48f503451a8d335189057a-8736x4896.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fc1d55c1da583552c0e48f503451a8d335189057a-8736x4896.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="responsive" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="shrink-0" loading="lazy"/></noscript></span></div></div></a><div class="flex-auto w-auto sm:ml-8 flex-1"><span class="text-sm text-gray-500 italic sm:pl-4">November 8th 2024</span><p class="font-bold text-[1rem] sm:pl-4 text-undefined" style="font-size:1.125rem"><a href="/view/shared-decision-making-is-essential-prior-to-sma-enhancing-treatments">Shared Decision-Making Is Essential Prior to SMA-Enhancing Treatments </a></p><div class=" sm:pl-4"><a class="text-sm text-[#00ADEF] underline italic" href="/authors/karen-jacobson-sive">Karen Jacobson-Sive</a></div><a href="/view/shared-decision-making-is-essential-prior-to-sma-enhancing-treatments"><div class="mt-2 ml-4"></div><div class="flex flex-row gap-2"></div><p class=" text-sm text-gray-500 py-1 sm:pl-4">Perspectives of patients with spinal muscular atrophy (SMA) and their caregivers should be weighed before making decisions around SMA-enhancing treatments. </p><div class="pl-4"></div></a><div class="flex flex-col sm:flex-row pl-2 mt-4"></div></div></div></div></div></div><div class="w-full h-full"><hr class="mt-1 w-full " style="border-top-width:2px;border-top-color:#F3F4F6"/><div class="w-full h-full"><div class="flex flex-col sm:flex-row justify-center align-center w-100% "><div class="flex flex-col justify-center sm:flex-row py-4 " style="background-color:transparent;border-color:#F3F4F6;border-width:0;border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem"><a href="/view/research-reveals-common-types-of-rituximab-induced-interstitial-lung-disease-in-patients-with-lymphoma"><div class="sm:w-[288px] h-100% mt-2"><div class=""><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;padding-top:60.66666666666667%"></span><img alt="doc reviewing lung report | Image Credit: © meeboonstudio - stock.adobe.com" title="doc reviewing lung report | Image Credit: © meeboonstudio - stock.adobe.com" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="responsive" class="shrink-0" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="doc reviewing lung report | Image Credit: © meeboonstudio - stock.adobe.com" title="doc reviewing lung report | Image Credit: © meeboonstudio - stock.adobe.com" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F877b0bbc24b826cebff91a2ed1be5d858fe976a1-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=75 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F877b0bbc24b826cebff91a2ed1be5d858fe976a1-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=75 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F877b0bbc24b826cebff91a2ed1be5d858fe976a1-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=75 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F877b0bbc24b826cebff91a2ed1be5d858fe976a1-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=75 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F877b0bbc24b826cebff91a2ed1be5d858fe976a1-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=75 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F877b0bbc24b826cebff91a2ed1be5d858fe976a1-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=75 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F877b0bbc24b826cebff91a2ed1be5d858fe976a1-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F877b0bbc24b826cebff91a2ed1be5d858fe976a1-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F877b0bbc24b826cebff91a2ed1be5d858fe976a1-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="responsive" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="shrink-0" loading="lazy"/></noscript></span></div></div></a><div class="flex-auto w-auto sm:ml-8 flex-1"><span class="text-sm text-gray-500 italic sm:pl-4">November 8th 2024</span><p class="font-bold text-[1rem] sm:pl-4 text-undefined" style="font-size:1.125rem"><a href="/view/research-reveals-common-types-of-rituximab-induced-interstitial-lung-disease-in-patients-with-lymphoma">Research Reveals Common Types of Rituximab-Induced Interstitial Lung Disease in Patients With Lymphoma</a></p><div class=" sm:pl-4"><a class="text-sm text-[#00ADEF] underline italic" href="/authors/karen-jacobson-sive">Karen Jacobson-Sive</a></div><a href="/view/research-reveals-common-types-of-rituximab-induced-interstitial-lung-disease-in-patients-with-lymphoma"><div class="mt-2 ml-4"></div><div class="flex flex-row gap-2"></div><p class=" text-sm text-gray-500 py-1 sm:pl-4">Rituximab-induced interstitial lung disease in patients with non-Hodgkin lymphoma presents with distinct clinical characteristics and bronchoalveolar lavage results.</p><div class="pl-4"></div></a><div class="flex flex-col sm:flex-row pl-2 mt-4"></div></div></div></div></div></div><div class="w-full h-full"><hr class="mt-1 w-full " style="border-top-width:2px;border-top-color:#F3F4F6"/><div class="w-full h-full"><div class="flex flex-col sm:flex-row justify-center align-center w-100% "><div class="flex flex-col justify-center sm:flex-row py-4 " style="background-color:transparent;border-color:#F3F4F6;border-width:0;border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem"><a href="/view/zanubrutinib-more-effective-than-ibrutinib-in-treating-patients-with-relapsed-refractory-cll-sll"><div class="sm:w-[288px] h-100% mt-2"><div class=""><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;padding-top:66.66666666666666%"></span><img alt="Stethoscope chart graph data | Image Credit: © amazing studio - stock.adobe.com" title="Stethoscope chart graph data | Image Credit: © amazing studio - stock.adobe.com" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="responsive" class="shrink-0" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="Stethoscope chart graph data | Image Credit: © amazing studio - stock.adobe.com" title="Stethoscope chart graph data | Image Credit: © amazing studio - stock.adobe.com" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fe825022f10d04a8c8b873d06455d4327ec5a3449-1200x800.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=75 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fe825022f10d04a8c8b873d06455d4327ec5a3449-1200x800.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=75 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fe825022f10d04a8c8b873d06455d4327ec5a3449-1200x800.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=75 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fe825022f10d04a8c8b873d06455d4327ec5a3449-1200x800.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=75 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fe825022f10d04a8c8b873d06455d4327ec5a3449-1200x800.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=75 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fe825022f10d04a8c8b873d06455d4327ec5a3449-1200x800.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=75 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fe825022f10d04a8c8b873d06455d4327ec5a3449-1200x800.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fe825022f10d04a8c8b873d06455d4327ec5a3449-1200x800.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fe825022f10d04a8c8b873d06455d4327ec5a3449-1200x800.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="responsive" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="shrink-0" loading="lazy"/></noscript></span></div></div></a><div class="flex-auto w-auto sm:ml-8 flex-1"><span class="text-sm text-gray-500 italic sm:pl-4">October 30th 2024</span><p class="font-bold text-[1rem] sm:pl-4 text-undefined" style="font-size:1.125rem"><a href="/view/zanubrutinib-more-effective-than-ibrutinib-in-treating-patients-with-relapsed-refractory-cll-sll">Zanubrutinib More Effective Than Ibrutinib in Treating Patients With Relapsed/Refractory CLL, SLL</a></p><div class=" sm:pl-4"><a class="text-sm text-[#00ADEF] underline italic" href="/authors/karen-jacobson-sive">Karen Jacobson-Sive</a></div><a href="/view/zanubrutinib-more-effective-than-ibrutinib-in-treating-patients-with-relapsed-refractory-cll-sll"><div class="mt-2 ml-4"></div><div class="flex flex-row gap-2"></div><p class=" text-sm text-gray-500 py-1 sm:pl-4">The long-term response rate for zanubrutinib was better than ibrutinib in patients with relapsed/refractory chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). </p><div class="pl-4"></div></a><div class="flex flex-col sm:flex-row pl-2 mt-4"></div></div></div></div></div></div><div class="w-full h-full"><hr class="mt-1 w-full " style="border-top-width:2px;border-top-color:#F3F4F6"/><div class="w-full h-full"><div class="flex flex-col sm:flex-row justify-center align-center w-100% "><div class="flex flex-col justify-center sm:flex-row py-4 " style="background-color:transparent;border-color:#F3F4F6;border-width:0;border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem"><a href="/view/oral-function-impairment-varies-across-adult-patients-with-sma"><div class="sm:w-[288px] h-100% mt-2"><div class=""><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;padding-top:66.67985753858329%"></span><img alt="SMA type is a strong predictor of some oral functioning in affected patients | image credit: RTimages - stock.adobe.com" title="SMA type is a strong predictor of some oral functioning in affected patients | image credit: RTimages - stock.adobe.com" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="responsive" class="shrink-0" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="SMA type is a strong predictor of some oral functioning in affected patients | image credit: RTimages - stock.adobe.com" title="SMA type is a strong predictor of some oral functioning in affected patients | image credit: RTimages - stock.adobe.com" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F98dc89c3c2a5e376594135bf100d2a45ee3df751-5054x3370.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=75 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F98dc89c3c2a5e376594135bf100d2a45ee3df751-5054x3370.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=75 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F98dc89c3c2a5e376594135bf100d2a45ee3df751-5054x3370.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=75 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F98dc89c3c2a5e376594135bf100d2a45ee3df751-5054x3370.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=75 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F98dc89c3c2a5e376594135bf100d2a45ee3df751-5054x3370.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=75 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F98dc89c3c2a5e376594135bf100d2a45ee3df751-5054x3370.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=75 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F98dc89c3c2a5e376594135bf100d2a45ee3df751-5054x3370.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F98dc89c3c2a5e376594135bf100d2a45ee3df751-5054x3370.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F98dc89c3c2a5e376594135bf100d2a45ee3df751-5054x3370.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="responsive" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="shrink-0" loading="lazy"/></noscript></span></div></div></a><div class="flex-auto w-auto sm:ml-8 flex-1"><span class="text-sm text-gray-500 italic sm:pl-4">October 28th 2024</span><p class="font-bold text-[1rem] sm:pl-4 text-undefined" style="font-size:1.125rem"><a href="/view/oral-function-impairment-varies-across-adult-patients-with-sma">Oral Function Impairment Varies Across Adult Patients With SMA</a></p><div class=" sm:pl-4"><a class="text-sm text-[#00ADEF] underline italic" href="/authors/karen-jacobson-sive">Karen Jacobson-Sive</a></div><a href="/view/oral-function-impairment-varies-across-adult-patients-with-sma"><div class="mt-2 ml-4"></div><div class="flex flex-row gap-2"></div><p class=" text-sm text-gray-500 py-1 sm:pl-4">Oral function should be measured routinely to determine individual bulbar involvement stages in spinal muscular atrophy (SMA). </p><div class="pl-4"></div></a><div class="flex flex-col sm:flex-row pl-2 mt-4"></div></div></div></div></div></div><div class="w-full h-full"><hr class="mt-1 w-full " style="border-top-width:2px;border-top-color:#F3F4F6"/><div class="w-full h-full"><div class="flex flex-col sm:flex-row justify-center align-center w-100% "><div class="flex flex-col justify-center sm:flex-row py-4 " style="background-color:transparent;border-color:#F3F4F6;border-width:0;border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem"><a href="/view/melanoma-risk-doubled-for-monoclonal-b-cell-lymphocytosis"><div class="sm:w-[288px] h-100% mt-2"><div class=""><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;padding-top:66.66666666666666%"></span><img alt="Skin Cancer Potential | Image Credit: © Monstar Studio-stock.adobe.com" title="Skin Cancer Potential | Image Credit: © Monstar Studio-stock.adobe.com" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="responsive" class="shrink-0" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="Skin Cancer Potential | Image Credit: © Monstar Studio-stock.adobe.com" title="Skin Cancer Potential | Image Credit: © Monstar Studio-stock.adobe.com" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F739c7a6180c80ee48c24f41b112dab5177075f4e-5184x3456.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=75 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F739c7a6180c80ee48c24f41b112dab5177075f4e-5184x3456.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=75 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F739c7a6180c80ee48c24f41b112dab5177075f4e-5184x3456.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=75 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F739c7a6180c80ee48c24f41b112dab5177075f4e-5184x3456.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=75 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F739c7a6180c80ee48c24f41b112dab5177075f4e-5184x3456.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=75 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F739c7a6180c80ee48c24f41b112dab5177075f4e-5184x3456.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=75 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F739c7a6180c80ee48c24f41b112dab5177075f4e-5184x3456.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F739c7a6180c80ee48c24f41b112dab5177075f4e-5184x3456.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F739c7a6180c80ee48c24f41b112dab5177075f4e-5184x3456.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="responsive" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="shrink-0" loading="lazy"/></noscript></span></div></div></a><div class="flex-auto w-auto sm:ml-8 flex-1"><span class="text-sm text-gray-500 italic sm:pl-4">October 16th 2024</span><p class="font-bold text-[1rem] sm:pl-4 text-undefined" style="font-size:1.125rem"><a href="/view/melanoma-risk-doubled-for-monoclonal-b-cell-lymphocytosis">Melanoma Risk Doubled for Monoclonal B-Cell Lymphocytosis</a></p><div class=" sm:pl-4"><a class="text-sm text-[#00ADEF] underline italic" href="/authors/karen-jacobson-sive">Karen Jacobson-Sive</a></div><a href="/view/melanoma-risk-doubled-for-monoclonal-b-cell-lymphocytosis"><div class="mt-2 ml-4"></div><div class="flex flex-row gap-2"></div><p class=" text-sm text-gray-500 py-1 sm:pl-4">Patients with low-count chronic lymphocytic leukemia phenotype monoclonal B-cell lymphocytosis had a 1.86-fold greater risk of melanoma. </p><div class="pl-4"></div></a><div class="flex flex-col sm:flex-row pl-2 mt-4"></div></div></div></div></div></div><div class="w-full h-full"><hr class="mt-1 w-full " style="border-top-width:2px;border-top-color:#F3F4F6"/><div class="flex md:hidden justify-center items-center"></div><div class="w-full h-full"><div class="flex flex-col sm:flex-row justify-center align-center w-100% "><div class="flex flex-col justify-center sm:flex-row py-4 " style="background-color:transparent;border-color:#F3F4F6;border-width:0;border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem"><a href="/view/breaking-novel-prognostic-biomarkers-discovered-for-sma"><div class="sm:w-[288px] h-100% mt-2"><div class=""><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;padding-top:66.66666666666666%"></span><img alt="Biomarker identification has the potential to transform screening, early identification and treatment for diseases like SMA | image credit: Катерина Євтехова - stock.adobe.com" title="Biomarker identification has the potential to transform screening, early identification and treatment for diseases like SMA | image credit: Катерина Євтехова - stock.adobe.com" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="responsive" class="shrink-0" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="Biomarker identification has the potential to transform screening, early identification and treatment for diseases like SMA | image credit: Катерина Євтехова - stock.adobe.com" title="Biomarker identification has the potential to transform screening, early identification and treatment for diseases like SMA | image credit: Катерина Євтехова - stock.adobe.com" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fd3eea8b1d68140d8cbdd9ad2d33f356568e44816-5376x3584.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=75 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fd3eea8b1d68140d8cbdd9ad2d33f356568e44816-5376x3584.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=75 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fd3eea8b1d68140d8cbdd9ad2d33f356568e44816-5376x3584.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=75 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fd3eea8b1d68140d8cbdd9ad2d33f356568e44816-5376x3584.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=75 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fd3eea8b1d68140d8cbdd9ad2d33f356568e44816-5376x3584.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=75 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fd3eea8b1d68140d8cbdd9ad2d33f356568e44816-5376x3584.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=75 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fd3eea8b1d68140d8cbdd9ad2d33f356568e44816-5376x3584.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fd3eea8b1d68140d8cbdd9ad2d33f356568e44816-5376x3584.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fd3eea8b1d68140d8cbdd9ad2d33f356568e44816-5376x3584.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="responsive" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="shrink-0" loading="lazy"/></noscript></span></div></div></a><div class="flex-auto w-auto sm:ml-8 flex-1"><span class="text-sm text-gray-500 italic sm:pl-4">October 9th 2024</span><p class="font-bold text-[1rem] sm:pl-4 text-undefined" style="font-size:1.125rem"><a href="/view/breaking-novel-prognostic-biomarkers-discovered-for-sma">Novel Prognostic Biomarkers Discovered for SMA</a></p><div class=" sm:pl-4"><a class="text-sm text-[#00ADEF] underline italic" href="/authors/karen-jacobson-sive">Karen Jacobson-Sive</a></div><a href="/view/breaking-novel-prognostic-biomarkers-discovered-for-sma"><div class="mt-2 ml-4"></div><div class="flex flex-row gap-2"></div><p class=" text-sm text-gray-500 py-1 sm:pl-4">CNTN1 and NRXN3 clearly differentiated severe and milder forms of spinal muscular atrophy (SMA). </p><div class="pl-4"></div></a><div class="flex flex-col sm:flex-row pl-2 mt-4"></div></div></div></div></div></div><div class="w-full h-full"><hr class="mt-1 w-full " style="border-top-width:2px;border-top-color:#F3F4F6"/><div class="w-full h-full"><div class="flex flex-col sm:flex-row justify-center align-center w-100% "><div class="flex flex-col justify-center sm:flex-row py-4 " style="background-color:transparent;border-color:#F3F4F6;border-width:0;border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem"><a href="/view/voretigene-neparvovec-helps-patients-with-rpe65-related-retinopathy-regain-bilateral-function"><div class="sm:w-[288px] h-100% mt-2"><div class=""><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;padding-top:52.416666666666664%"></span><img alt="eye computer | Image Credit: © eevi - stock.adobe.com" title="eye computer | Image Credit: © eevi - stock.adobe.com" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="responsive" class="shrink-0" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="eye computer | Image Credit: © eevi - stock.adobe.com" title="eye computer | Image Credit: © eevi - stock.adobe.com" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F58ebe9965752c640b53e33522ef233409ac2c4cf-1200x629.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=75 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F58ebe9965752c640b53e33522ef233409ac2c4cf-1200x629.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=75 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F58ebe9965752c640b53e33522ef233409ac2c4cf-1200x629.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=75 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F58ebe9965752c640b53e33522ef233409ac2c4cf-1200x629.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=75 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F58ebe9965752c640b53e33522ef233409ac2c4cf-1200x629.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=75 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F58ebe9965752c640b53e33522ef233409ac2c4cf-1200x629.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=75 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F58ebe9965752c640b53e33522ef233409ac2c4cf-1200x629.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F58ebe9965752c640b53e33522ef233409ac2c4cf-1200x629.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F58ebe9965752c640b53e33522ef233409ac2c4cf-1200x629.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="responsive" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="shrink-0" loading="lazy"/></noscript></span></div></div></a><div class="flex-auto w-auto sm:ml-8 flex-1"><span class="text-sm text-gray-500 italic sm:pl-4">October 9th 2024</span><p class="font-bold text-[1rem] sm:pl-4 text-undefined" style="font-size:1.125rem"><a href="/view/voretigene-neparvovec-helps-patients-with-rpe65-related-retinopathy-regain-bilateral-function">Voretigene Neparvovec Helps Patients With RPE65-Related Retinopathy Regain Bilateral Function</a></p><div class=" sm:pl-4"><a class="text-sm text-[#00ADEF] underline italic" href="/authors/karen-jacobson-sive">Karen Jacobson-Sive</a></div><a href="/view/voretigene-neparvovec-helps-patients-with-rpe65-related-retinopathy-regain-bilateral-function"><div class="mt-2 ml-4"></div><div class="flex flex-row gap-2"></div><p class=" text-sm text-gray-500 py-1 sm:pl-4">Three patients with RPE65-related retinopathy showed improved function in both eyes following gene augmentation therapy treatment with voretigene neparvovec.</p><div class="pl-4"></div></a><div class="flex flex-col sm:flex-row pl-2 mt-4"></div></div></div></div></div></div><div class="w-full h-full"><hr class="mt-1 w-full " style="border-top-width:2px;border-top-color:#F3F4F6"/><div class="w-full h-full"><div class="flex flex-col sm:flex-row justify-center align-center w-100% "><div class="flex flex-col justify-center sm:flex-row py-4 " style="background-color:transparent;border-color:#F3F4F6;border-width:0;border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem"><a href="/view/preclinical-model-suggests-efficacy-of-combining-capivasertib-with-venetoclax-against-dlbcl"><div class="sm:w-[288px] h-100% mt-2"><div class=""><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;padding-top:66.640625%"></span><img alt="Microbiologist conducts research in laboratory | Image Credit: © Seventyfour - stock.adobe.com" title="Microbiologist conducts research in laboratory | Image Credit: © Seventyfour - stock.adobe.com" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="responsive" class="shrink-0" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="Microbiologist conducts research in laboratory | Image Credit: © Seventyfour - stock.adobe.com" title="Microbiologist conducts research in laboratory | Image Credit: © Seventyfour - stock.adobe.com" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fa329387e322ca781d0a66405a3ad00034bd346e8-1280x853.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=75 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fa329387e322ca781d0a66405a3ad00034bd346e8-1280x853.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=75 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fa329387e322ca781d0a66405a3ad00034bd346e8-1280x853.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=75 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fa329387e322ca781d0a66405a3ad00034bd346e8-1280x853.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=75 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fa329387e322ca781d0a66405a3ad00034bd346e8-1280x853.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=75 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fa329387e322ca781d0a66405a3ad00034bd346e8-1280x853.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=75 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fa329387e322ca781d0a66405a3ad00034bd346e8-1280x853.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fa329387e322ca781d0a66405a3ad00034bd346e8-1280x853.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fa329387e322ca781d0a66405a3ad00034bd346e8-1280x853.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="responsive" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="shrink-0" loading="lazy"/></noscript></span></div></div></a><div class="flex-auto w-auto sm:ml-8 flex-1"><span class="text-sm text-gray-500 italic sm:pl-4">October 8th 2024</span><p class="font-bold text-[1rem] sm:pl-4 text-undefined" style="font-size:1.125rem"><a href="/view/preclinical-model-suggests-efficacy-of-combining-capivasertib-with-venetoclax-against-dlbcl">Preclinical Model Suggests Efficacy of Combining Capivasertib With Venetoclax Against DLBCL</a></p><div class=" sm:pl-4"><a class="text-sm text-[#00ADEF] underline italic" href="/authors/karen-jacobson-sive">Karen Jacobson-Sive</a></div><a href="/view/preclinical-model-suggests-efficacy-of-combining-capivasertib-with-venetoclax-against-dlbcl"><div class="mt-2 ml-4"></div><div class="flex flex-row gap-2"></div><p class=" text-sm text-gray-500 py-1 sm:pl-4">Capivasertib, in combination with venetoclax, produced promising responses in preclinical models of diffuse large B-cell lymphoma (DLBCL).</p><div class="pl-4"></div></a><div class="flex flex-col sm:flex-row pl-2 mt-4"></div></div></div></div></div></div><div class="w-full h-full"><hr class="mt-1 w-full " style="border-top-width:2px;border-top-color:#F3F4F6"/><div class="w-full h-full"><div class="flex flex-col sm:flex-row justify-center align-center w-100% "><div class="flex flex-col justify-center sm:flex-row py-4 " style="background-color:transparent;border-color:#F3F4F6;border-width:0;border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem"><a href="/view/b-cell-activating-factor-receptor-car-t-therapy-holds-promise-for-cll"><div class="sm:w-[288px] h-100% mt-2"><div class=""><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;padding-top:61.5%"></span><img alt="CAR T cell | Image Credit: © Christoph Burgstedt - stock.adobe.com" title="CAR T cell | Image Credit: © Christoph Burgstedt - stock.adobe.com" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="responsive" class="shrink-0" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="CAR T cell | Image Credit: © Christoph Burgstedt - stock.adobe.com" title="CAR T cell | Image Credit: © Christoph Burgstedt - stock.adobe.com" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F8221a6bc7f23de994c5e2045cd76cd6eb0bb6393-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=75 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F8221a6bc7f23de994c5e2045cd76cd6eb0bb6393-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=75 750w, 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/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F8221a6bc7f23de994c5e2045cd76cd6eb0bb6393-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F8221a6bc7f23de994c5e2045cd76cd6eb0bb6393-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="responsive" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="shrink-0" loading="lazy"/></noscript></span></div></div></a><div class="flex-auto w-auto sm:ml-8 flex-1"><span class="text-sm text-gray-500 italic sm:pl-4">October 3rd 2024</span><p class="font-bold text-[1rem] sm:pl-4 text-undefined" style="font-size:1.125rem"><a href="/view/b-cell-activating-factor-receptor-car-t-therapy-holds-promise-for-cll">B-Cell Activating Factor Receptor CAR T Therapy Holds Promise for CLL</a></p><div class=" sm:pl-4"><a class="text-sm text-[#00ADEF] underline italic" href="/authors/karen-jacobson-sive">Karen Jacobson-Sive</a></div><a href="/view/b-cell-activating-factor-receptor-car-t-therapy-holds-promise-for-cll"><div class="mt-2 ml-4"></div><div class="flex flex-row gap-2"></div><p class=" text-sm text-gray-500 py-1 sm:pl-4">B-cell activating factor receptor chimeric antigen receptor (CAR) T-cell therapy caused cytotoxic effects on all chronic lymphocytic leukemia (CLL) cell lines.</p><div class="pl-4"></div></a><div class="flex flex-col sm:flex-row pl-2 mt-4"></div></div></div></div></div></div><div class="w-full h-full"><hr class="mt-1 w-full " style="border-top-width:2px;border-top-color:#F3F4F6"/><div class="w-full h-full"><div class="flex flex-col sm:flex-row justify-center align-center w-100% "><div class="flex flex-col justify-center sm:flex-row py-4 " style="background-color:transparent;border-color:#F3F4F6;border-width:0;border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem"><a href="/view/urinary-angiotensinogen-predicts-persistent-albuminuria-in-sickle-cell-anemia"><div class="sm:w-[288px] h-100% mt-2"><div class=""><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;padding-top:56.14035087719298%"></span><img alt="Sickle cell anemia affects an estimated 100,000 people in the US | image credit: Studios - stock.adobe.com" title="Sickle cell anemia affects an estimated 100,000 people in the US | image credit: Studios - stock.adobe.com" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="responsive" class="shrink-0" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="Sickle cell anemia affects an estimated 100,000 people in the US | image credit: Studios - stock.adobe.com" title="Sickle cell anemia affects an estimated 100,000 people in the US | image credit: Studios - stock.adobe.com" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F84d5192793bf6c0f52bb7fedba2532f15ff5e440-5472x3072.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=75 640w, 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/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F84d5192793bf6c0f52bb7fedba2532f15ff5e440-5472x3072.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F84d5192793bf6c0f52bb7fedba2532f15ff5e440-5472x3072.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F84d5192793bf6c0f52bb7fedba2532f15ff5e440-5472x3072.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="responsive" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="shrink-0" loading="lazy"/></noscript></span></div></div></a><div class="flex-auto w-auto sm:ml-8 flex-1"><span class="text-sm text-gray-500 italic sm:pl-4">September 20th 2024</span><p class="font-bold text-[1rem] sm:pl-4 text-undefined" style="font-size:1.125rem"><a href="/view/urinary-angiotensinogen-predicts-persistent-albuminuria-in-sickle-cell-anemia">Urinary Angiotensinogen Predicts Persistent Albuminuria in Sickle Cell Anemia </a></p><div class=" sm:pl-4"><a class="text-sm text-[#00ADEF] underline italic" href="/authors/karen-jacobson-sive">Karen Jacobson-Sive</a></div><a href="/view/urinary-angiotensinogen-predicts-persistent-albuminuria-in-sickle-cell-anemia"><div class="mt-2 ml-4"></div><div class="flex flex-row gap-2"></div><p class=" text-sm text-gray-500 py-1 sm:pl-4">Patients with sickle cell anemia (SCA) and persistent albuminuria (PA) exhibited significantly higher levels of urinary angiotensinogen (AGT). </p><div class="pl-4"></div></a><div class="flex flex-col sm:flex-row pl-2 mt-4"></div></div></div></div></div></div><div class="w-full h-full"><hr class="mt-1 w-full " style="border-top-width:2px;border-top-color:#F3F4F6"/><div class="w-full h-full"><div class="flex flex-col sm:flex-row justify-center align-center w-100% "><div class="flex flex-col justify-center sm:flex-row py-4 " style="background-color:transparent;border-color:#F3F4F6;border-width:0;border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem"><a href="/view/meta-study-analyzes-immunosuppressive-protocols-for-aav-gene-therapy-for-monogenic-disorders"><div class="sm:w-[288px] h-100% mt-2"><div class=""><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;padding-top:66.64956387891226%"></span><img alt="Gene editing | Image Credit: © Degimages - stock.adobe.com" title="Gene editing | Image Credit: © Degimages - stock.adobe.com" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="responsive" class="shrink-0" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="Gene editing | Image Credit: © Degimages - stock.adobe.com" title="Gene editing | Image Credit: © Degimages - stock.adobe.com" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fdf17be9ab7803f252c60bc1d6eea8586c27dcc08-3898x2598.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=75 640w, 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/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fdf17be9ab7803f252c60bc1d6eea8586c27dcc08-3898x2598.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fdf17be9ab7803f252c60bc1d6eea8586c27dcc08-3898x2598.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fdf17be9ab7803f252c60bc1d6eea8586c27dcc08-3898x2598.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="responsive" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="shrink-0" loading="lazy"/></noscript></span></div></div></a><div class="flex-auto w-auto sm:ml-8 flex-1"><span class="text-sm text-gray-500 italic sm:pl-4">September 18th 2024</span><p class="font-bold text-[1rem] sm:pl-4 text-undefined" style="font-size:1.125rem"><a href="/view/meta-study-analyzes-immunosuppressive-protocols-for-aav-gene-therapy-for-monogenic-disorders">Meta-Study Analyzes Immunosuppressive Protocols for AAV Gene Therapy for Monogenic Disorders </a></p><div class=" sm:pl-4"><a class="text-sm text-[#00ADEF] underline italic" href="/authors/karen-jacobson-sive">Karen Jacobson-Sive</a></div><a href="/view/meta-study-analyzes-immunosuppressive-protocols-for-aav-gene-therapy-for-monogenic-disorders"><div class="mt-2 ml-4"></div><div class="flex flex-row gap-2"></div><p class=" text-sm text-gray-500 py-1 sm:pl-4">Immunosuppressants used in adeno-associated virus (AAV) gene therapy for monogenic disorders present an adverse effect profile that is consistent with high-dose steroid use in other conditions, according to a meta-study that analyzed immunosuppressive protocols.</p><div class="pl-4"></div></a><div class="flex flex-col sm:flex-row pl-2 mt-4"></div></div></div></div></div></div><div class="w-full h-full"><hr class="mt-1 w-full " style="border-top-width:2px;border-top-color:#F3F4F6"/><div class="w-full h-full"><div class="flex flex-col sm:flex-row justify-center align-center w-100% "><div class="flex flex-col justify-center sm:flex-row py-4 " style="background-color:transparent;border-color:#F3F4F6;border-width:0;border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem"><a href="/view/celiac-disease-associated-with-varying-risks-for-cancers"><div class="sm:w-[288px] h-100% mt-2"><div class=""><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;padding-top:61.5%"></span><img alt="Celiac disease and the body | Image Credit: reineg-stock.adobe.com" title="Celiac disease and the body | Image Credit: reineg-stock.adobe.com" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="responsive" class="shrink-0" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="Celiac disease and the body | Image Credit: reineg-stock.adobe.com" title="Celiac disease and the body | Image Credit: reineg-stock.adobe.com" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F8e2e6fd33c8007a04fbc52416154436ea411119a-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=75 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F8e2e6fd33c8007a04fbc52416154436ea411119a-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=75 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F8e2e6fd33c8007a04fbc52416154436ea411119a-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=75 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F8e2e6fd33c8007a04fbc52416154436ea411119a-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=75 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F8e2e6fd33c8007a04fbc52416154436ea411119a-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=75 1200w, 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style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="shrink-0" loading="lazy"/></noscript></span></div></div></a><div class="flex-auto w-auto sm:ml-8 flex-1"><span class="text-sm text-gray-500 italic sm:pl-4">September 13th 2024</span><p class="font-bold text-[1rem] sm:pl-4 text-undefined" style="font-size:1.125rem"><a href="/view/celiac-disease-associated-with-varying-risks-for-cancers">Celiac Disease Associated With Varying Risks for Cancers</a></p><div class=" sm:pl-4"><a class="text-sm text-[#00ADEF] underline italic" href="/authors/karen-jacobson-sive">Karen Jacobson-Sive</a></div><a href="/view/celiac-disease-associated-with-varying-risks-for-cancers"><div class="mt-2 ml-4"></div><div class="flex flex-row gap-2"></div><p class=" text-sm text-gray-500 py-1 sm:pl-4">Celiac disease presents a higher risk for developing malignant neoplasms, including small intestine, lymphoma, and skin cancers, but presents a lower risk for respiratory malignancies.</p><div class="pl-4"></div></a><div class="flex flex-col sm:flex-row pl-2 mt-4"></div></div></div></div></div></div><div class="w-full h-full"><hr class="mt-1 w-full " style="border-top-width:2px;border-top-color:#F3F4F6"/><div class="w-full h-full"><div class="flex flex-col sm:flex-row justify-center align-center w-100% "><div class="flex flex-col justify-center sm:flex-row py-4 " style="background-color:transparent;border-color:#F3F4F6;border-width:0;border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem"><a href="/view/key-biomarker-monitoring-improves-outcomes-in-asct-recipients-with-aml-mds"><div class="sm:w-[288px] h-100% mt-2"><div class=""><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;padding-top:52.33333333333333%"></span><img alt="AML | Image Credit: © Dzmitry - stock.adobe.com" title="AML | Image Credit: © Dzmitry - stock.adobe.com" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="responsive" class="shrink-0" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="AML | Image Credit: © Dzmitry - stock.adobe.com" title="AML | Image Credit: © Dzmitry - stock.adobe.com" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F81dec5b17e89f1a797ecfbc3293ad0c4e34bb3f4-1200x628.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=75 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F81dec5b17e89f1a797ecfbc3293ad0c4e34bb3f4-1200x628.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=75 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F81dec5b17e89f1a797ecfbc3293ad0c4e34bb3f4-1200x628.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=75 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F81dec5b17e89f1a797ecfbc3293ad0c4e34bb3f4-1200x628.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=75 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F81dec5b17e89f1a797ecfbc3293ad0c4e34bb3f4-1200x628.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=75 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F81dec5b17e89f1a797ecfbc3293ad0c4e34bb3f4-1200x628.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=75 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F81dec5b17e89f1a797ecfbc3293ad0c4e34bb3f4-1200x628.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F81dec5b17e89f1a797ecfbc3293ad0c4e34bb3f4-1200x628.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F81dec5b17e89f1a797ecfbc3293ad0c4e34bb3f4-1200x628.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="responsive" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="shrink-0" loading="lazy"/></noscript></span></div></div></a><div class="flex-auto w-auto sm:ml-8 flex-1"><span class="text-sm text-gray-500 italic sm:pl-4">September 9th 2024</span><p class="font-bold text-[1rem] sm:pl-4 text-undefined" style="font-size:1.125rem"><a href="/view/key-biomarker-monitoring-improves-outcomes-in-asct-recipients-with-aml-mds">Key Biomarker Monitoring Improves Outcomes in ASCT Recipients With AML, MDS</a></p><div class=" sm:pl-4"><a class="text-sm text-[#00ADEF] underline italic" href="/authors/karen-jacobson-sive">Karen Jacobson-Sive</a></div><a href="/view/key-biomarker-monitoring-improves-outcomes-in-asct-recipients-with-aml-mds"><div class="mt-2 ml-4"></div><div class="flex flex-row gap-2"></div><p class=" text-sm text-gray-500 py-1 sm:pl-4">Donor lymphocyte infusion, both alone and in combination with azacitidine, restored CD34 levels in two-thirds of patients with a baseline CD34 donor chimerism of less than 80%. </p><div class="pl-4"></div></a><div class="flex flex-col sm:flex-row pl-2 mt-4"></div></div></div></div></div></div><div class="w-full h-full"><hr class="mt-1 w-full " style="border-top-width:2px;border-top-color:#F3F4F6"/><div class="flex md:hidden justify-center items-center"></div><div class="w-full h-full"><div class="flex flex-col sm:flex-row justify-center align-center w-100% "><div class="flex flex-col justify-center sm:flex-row py-4 " style="background-color:transparent;border-color:#F3F4F6;border-width:0;border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem"><a href="/view/two-leukemia-stem-cell-subtypes-identified"><div class="sm:w-[288px] h-100% mt-2"><div class=""><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;padding-top:60.333333333333336%"></span><img alt="Enhanced image of leukemia | Image Credit: © freshidea - stock.adobe.com" title="Enhanced image of leukemia | Image Credit: © freshidea - stock.adobe.com" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="responsive" class="shrink-0" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="Enhanced image of leukemia | Image Credit: © freshidea - stock.adobe.com" title="Enhanced image of leukemia | Image Credit: © freshidea - stock.adobe.com" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F82bee2e7922cbccc67bfe1fca1c22fc317db5f15-1200x724.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=75 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F82bee2e7922cbccc67bfe1fca1c22fc317db5f15-1200x724.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=75 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F82bee2e7922cbccc67bfe1fca1c22fc317db5f15-1200x724.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=75 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F82bee2e7922cbccc67bfe1fca1c22fc317db5f15-1200x724.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=75 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F82bee2e7922cbccc67bfe1fca1c22fc317db5f15-1200x724.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=75 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F82bee2e7922cbccc67bfe1fca1c22fc317db5f15-1200x724.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=75 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F82bee2e7922cbccc67bfe1fca1c22fc317db5f15-1200x724.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F82bee2e7922cbccc67bfe1fca1c22fc317db5f15-1200x724.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F82bee2e7922cbccc67bfe1fca1c22fc317db5f15-1200x724.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="responsive" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="shrink-0" loading="lazy"/></noscript></span></div></div></a><div class="flex-auto w-auto sm:ml-8 flex-1"><span class="text-sm text-gray-500 italic sm:pl-4">September 6th 2024</span><p class="font-bold text-[1rem] sm:pl-4 text-undefined" style="font-size:1.125rem"><a href="/view/two-leukemia-stem-cell-subtypes-identified">Two Leukemia Stem Cell Subtypes Identified </a></p><div class=" sm:pl-4"><a class="text-sm text-[#00ADEF] underline italic" href="/authors/karen-jacobson-sive">Karen Jacobson-Sive</a></div><a href="/view/two-leukemia-stem-cell-subtypes-identified"><div class="mt-2 ml-4"></div><div class="flex flex-row gap-2"></div><p class=" text-sm text-gray-500 py-1 sm:pl-4">Researchers have discovered 2 leukemia stem cell subtypes with distinct epigenetic and transcriptional signatures.</p><div class="pl-4"></div></a><div class="flex flex-col sm:flex-row pl-2 mt-4"></div></div></div></div></div></div><div class="w-full h-full"><hr class="mt-1 w-full " style="border-top-width:2px;border-top-color:#F3F4F6"/><div class="w-full h-full"><div class="flex flex-col sm:flex-row justify-center align-center w-100% "><div class="flex flex-col justify-center sm:flex-row py-4 " style="background-color:transparent;border-color:#F3F4F6;border-width:0;border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem"><a href="/view/recombinant-hirudin-may-help-treat-diffuse-large-b-cell-lymphoma"><div class="sm:w-[288px] h-100% mt-2"><div class=""><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;padding-top:56.26339969372128%"></span><img alt="Recombinant Hirudin shows promise in the treament of DLBCL | image credit: David A Litman - stock.adobe.com" title="Recombinant Hirudin shows promise in the treament of DLBCL | image credit: David A Litman - stock.adobe.com" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="responsive" class="shrink-0" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="Recombinant Hirudin shows promise in the treament of DLBCL | image credit: David A Litman - stock.adobe.com" title="Recombinant Hirudin shows promise in the treament of DLBCL | image credit: David A Litman - stock.adobe.com" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F1ba373f5a004b284e540407fa01abbcee009de21-3265x1837.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=75 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F1ba373f5a004b284e540407fa01abbcee009de21-3265x1837.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=75 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F1ba373f5a004b284e540407fa01abbcee009de21-3265x1837.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=75 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F1ba373f5a004b284e540407fa01abbcee009de21-3265x1837.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=75 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F1ba373f5a004b284e540407fa01abbcee009de21-3265x1837.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=75 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F1ba373f5a004b284e540407fa01abbcee009de21-3265x1837.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=75 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F1ba373f5a004b284e540407fa01abbcee009de21-3265x1837.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F1ba373f5a004b284e540407fa01abbcee009de21-3265x1837.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F1ba373f5a004b284e540407fa01abbcee009de21-3265x1837.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="responsive" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="shrink-0" loading="lazy"/></noscript></span></div></div></a><div class="flex-auto w-auto sm:ml-8 flex-1"><span class="text-sm text-gray-500 italic sm:pl-4">September 5th 2024</span><p class="font-bold text-[1rem] sm:pl-4 text-undefined" style="font-size:1.125rem"><a href="/view/recombinant-hirudin-may-help-treat-diffuse-large-b-cell-lymphoma">Recombinant Hirudin May Help Treat Diffuse Large B-Cell Lymphoma  </a></p><div class=" sm:pl-4"><a class="text-sm text-[#00ADEF] underline italic" href="/authors/karen-jacobson-sive">Karen Jacobson-Sive</a></div><a href="/view/recombinant-hirudin-may-help-treat-diffuse-large-b-cell-lymphoma"><div class="mt-2 ml-4"></div><div class="flex flex-row gap-2"></div><p class=" text-sm text-gray-500 py-1 sm:pl-4">Recombinant Hirudin (rH) inhibited the polarization of M2-type macrophages and protease-activated receptor-1 (PAR-1) in diffuse large B-cell lymphoma (DLBCL). </p><div class="pl-4"></div></a><div class="flex flex-col sm:flex-row pl-2 mt-4"></div></div></div></div></div></div><div class="w-full h-full"><hr class="mt-1 w-full " style="border-top-width:2px;border-top-color:#F3F4F6"/><div class="w-full h-full"><div class="flex flex-col sm:flex-row justify-center align-center w-100% "><div class="flex flex-col justify-center sm:flex-row py-4 " style="background-color:transparent;border-color:#F3F4F6;border-width:0;border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem"><a href="/view/proximal-muscles-show-earlier-rns-response-in-mg-als"><div class="sm:w-[288px] h-100% mt-2"><div class=""><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;padding-top:61.5%"></span><img alt="concept of myasthenia gravis | Image Credit: syahrir-stock.adobe.com" title="concept of myasthenia gravis | Image Credit: syahrir-stock.adobe.com" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="responsive" class="shrink-0" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="concept of myasthenia gravis | Image Credit: syahrir-stock.adobe.com" title="concept of myasthenia gravis | Image Credit: syahrir-stock.adobe.com" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fa03f634f7e72aba0c27ffd91a254dc139df51993-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=75 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fa03f634f7e72aba0c27ffd91a254dc139df51993-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=75 750w, 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/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fa03f634f7e72aba0c27ffd91a254dc139df51993-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fa03f634f7e72aba0c27ffd91a254dc139df51993-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="responsive" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="shrink-0" loading="lazy"/></noscript></span></div></div></a><div class="flex-auto w-auto sm:ml-8 flex-1"><span class="text-sm text-gray-500 italic sm:pl-4">August 17th 2024</span><p class="font-bold text-[1rem] sm:pl-4 text-undefined" style="font-size:1.125rem"><a href="/view/proximal-muscles-show-earlier-rns-response-in-mg-als">Proximal Muscles Show Earlier RNS Response in MG, ALS</a></p><div class=" sm:pl-4"><a class="text-sm text-[#00ADEF] underline italic" href="/authors/karen-jacobson-sive">Karen Jacobson-Sive</a></div><a href="/view/proximal-muscles-show-earlier-rns-response-in-mg-als"><div class="mt-2 ml-4"></div><div class="flex flex-row gap-2"></div><p class=" text-sm text-gray-500 py-1 sm:pl-4">The decremental response follows repetitive nerve stimulation (RNS) completed earlier in proximal muscles compared with distal muscles in a study of patients with myasthenia gravis (MG) and amyotrophic lateral sclerosis (ALS). </p><div class="pl-4"></div></a><div class="flex flex-col sm:flex-row pl-2 mt-4"></div></div></div></div></div></div><div class="w-full h-full"><hr class="mt-1 w-full " style="border-top-width:2px;border-top-color:#F3F4F6"/><div class="w-full h-full"><div class="flex flex-col sm:flex-row justify-center align-center w-100% "><div class="flex flex-col justify-center sm:flex-row py-4 " style="background-color:transparent;border-color:#F3F4F6;border-width:0;border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem"><a href="/view/assessments-help-identify-patients-with-myasthenia-gravis-at-risk-for-respiratory-distress"><div class="sm:w-[288px] h-100% mt-2"><div class=""><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;padding-top:61.5%"></span><img alt="Patient in resp distress | Image Credit: New Africa-stock.adobe.com" title="Patient in resp distress | Image Credit: New Africa-stock.adobe.com" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="responsive" class="shrink-0" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="Patient in resp distress | Image Credit: New Africa-stock.adobe.com" title="Patient in resp distress | Image Credit: New Africa-stock.adobe.com" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F0ef4b8214ac2b19ec0e21533a366d6dd9d0402fe-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=75 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F0ef4b8214ac2b19ec0e21533a366d6dd9d0402fe-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=75 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F0ef4b8214ac2b19ec0e21533a366d6dd9d0402fe-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=75 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F0ef4b8214ac2b19ec0e21533a366d6dd9d0402fe-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=75 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F0ef4b8214ac2b19ec0e21533a366d6dd9d0402fe-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=75 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F0ef4b8214ac2b19ec0e21533a366d6dd9d0402fe-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=75 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F0ef4b8214ac2b19ec0e21533a366d6dd9d0402fe-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F0ef4b8214ac2b19ec0e21533a366d6dd9d0402fe-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F0ef4b8214ac2b19ec0e21533a366d6dd9d0402fe-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="responsive" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="shrink-0" loading="lazy"/></noscript></span></div></div></a><div class="flex-auto w-auto sm:ml-8 flex-1"><span class="text-sm text-gray-500 italic sm:pl-4">August 13th 2024</span><p class="font-bold text-[1rem] sm:pl-4 text-undefined" style="font-size:1.125rem"><a href="/view/assessments-help-identify-patients-with-myasthenia-gravis-at-risk-for-respiratory-distress">Assessments Help Identify Patients With Myasthenia Gravis at Risk for Respiratory Distress</a></p><div class=" sm:pl-4"><a class="text-sm text-[#00ADEF] underline italic" href="/authors/karen-jacobson-sive">Karen Jacobson-Sive</a></div><a href="/view/assessments-help-identify-patients-with-myasthenia-gravis-at-risk-for-respiratory-distress"><div class="mt-2 ml-4"></div><div class="flex flex-row gap-2"></div><p class=" text-sm text-gray-500 py-1 sm:pl-4">A series of portable respiratory function tests for patients with mild to moderate myasthenia gravis (MG) were found to be useful methods to diagnose previously unidentified at-risk cases for respiratory deterioration. </p><div class="pl-4"></div></a><div class="flex flex-col sm:flex-row pl-2 mt-4"></div></div></div></div></div></div><div class="w-full h-full"><hr class="mt-1 w-full " style="border-top-width:2px;border-top-color:#F3F4F6"/><div class="w-full h-full"><div class="flex flex-col sm:flex-row justify-center align-center w-100% "><div class="flex flex-col justify-center sm:flex-row py-4 " style="background-color:transparent;border-color:#F3F4F6;border-width:0;border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem"><a href="/view/fruit-and-vegetables-outperform-medication-and-baking-soda-to-treat-hypertension"><div class="sm:w-[288px] h-100% mt-2"><div class=""><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;padding-top:56.25355315520182%"></span><img alt="Fruits and vegetable intake provides proven benefits for patients with hypertension | image credit: peangdao - stock.adobe.com" title="Fruits and vegetable intake provides proven benefits for patients with hypertension | image credit: peangdao - stock.adobe.com" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="responsive" class="shrink-0" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="Fruits and vegetable intake provides proven benefits for patients with hypertension | image credit: peangdao - stock.adobe.com" title="Fruits and vegetable intake provides proven benefits for patients with hypertension | image credit: peangdao - stock.adobe.com" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F09611c2abe336f9106591bacc303fa1b4bb261b5-7036x3958.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=75 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F09611c2abe336f9106591bacc303fa1b4bb261b5-7036x3958.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=75 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F09611c2abe336f9106591bacc303fa1b4bb261b5-7036x3958.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=75 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F09611c2abe336f9106591bacc303fa1b4bb261b5-7036x3958.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=75 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F09611c2abe336f9106591bacc303fa1b4bb261b5-7036x3958.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=75 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F09611c2abe336f9106591bacc303fa1b4bb261b5-7036x3958.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=75 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F09611c2abe336f9106591bacc303fa1b4bb261b5-7036x3958.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F09611c2abe336f9106591bacc303fa1b4bb261b5-7036x3958.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F09611c2abe336f9106591bacc303fa1b4bb261b5-7036x3958.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="responsive" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="shrink-0" loading="lazy"/></noscript></span></div></div></a><div class="flex-auto w-auto sm:ml-8 flex-1"><span class="text-sm text-gray-500 italic sm:pl-4">August 13th 2024</span><p class="font-bold text-[1rem] sm:pl-4 text-undefined" style="font-size:1.125rem"><a href="/view/fruit-and-vegetables-outperform-medication-and-baking-soda-to-treat-hypertension">Fruit and Vegetables Outperform Medication and Baking Soda to Treat Hypertension </a></p><div class=" sm:pl-4"><a class="text-sm text-[#00ADEF] underline italic" href="/authors/karen-jacobson-sive">Karen Jacobson-Sive</a></div><a href="/view/fruit-and-vegetables-outperform-medication-and-baking-soda-to-treat-hypertension"><div class="mt-2 ml-4"></div><div class="flex flex-row gap-2"></div><p class=" text-sm text-gray-500 py-1 sm:pl-4">Patients with hypertension-related chronic kidney disease who increased daily fruit and vegetable consumption showed improved cardiovascular health and reduced blood pressure compared with participants who added baking soda to their diet or who received pharmacological-only treatment. </p><div class="pl-4"></div></a><div class="flex flex-col sm:flex-row pl-2 mt-4"></div></div></div></div></div></div><div class="w-full h-full"><hr class="mt-1 w-full " style="border-top-width:2px;border-top-color:#F3F4F6"/><div class="w-full h-full"><div class="flex flex-col sm:flex-row justify-center align-center w-100% "><div class="flex flex-col justify-center sm:flex-row py-4 " style="background-color:transparent;border-color:#F3F4F6;border-width:0;border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem"><a href="/view/crispr-cas9-gene-therapy-holds-promise-to-treat-epidermolysis-bullosa"><div class="sm:w-[288px] h-100% mt-2"><div class=""><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;padding-top:61.5%"></span><img alt="epidermolysis bullosa | Image Credit: Yurii Kibalnik-stock.adobe.com" title="epidermolysis bullosa | Image Credit: Yurii Kibalnik-stock.adobe.com" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="responsive" class="shrink-0" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="epidermolysis bullosa | Image Credit: Yurii Kibalnik-stock.adobe.com" title="epidermolysis bullosa | Image Credit: Yurii Kibalnik-stock.adobe.com" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fb4db9eee75fd88b300f5a6df4aa74dc6ea845477-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=75 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fb4db9eee75fd88b300f5a6df4aa74dc6ea845477-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=75 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fb4db9eee75fd88b300f5a6df4aa74dc6ea845477-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=75 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fb4db9eee75fd88b300f5a6df4aa74dc6ea845477-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=75 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fb4db9eee75fd88b300f5a6df4aa74dc6ea845477-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=75 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fb4db9eee75fd88b300f5a6df4aa74dc6ea845477-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=75 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fb4db9eee75fd88b300f5a6df4aa74dc6ea845477-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fb4db9eee75fd88b300f5a6df4aa74dc6ea845477-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fb4db9eee75fd88b300f5a6df4aa74dc6ea845477-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="responsive" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="shrink-0" loading="lazy"/></noscript></span></div></div></a><div class="flex-auto w-auto sm:ml-8 flex-1"><span class="text-sm text-gray-500 italic sm:pl-4">August 2nd 2024</span><p class="font-bold text-[1rem] sm:pl-4 text-undefined" style="font-size:1.125rem"><a href="/view/crispr-cas9-gene-therapy-holds-promise-to-treat-epidermolysis-bullosa">CRISPR/Cas9 Gene Therapy Holds Promise to Treat Epidermolysis Bullosa </a></p><div class=" sm:pl-4"><a class="text-sm text-[#00ADEF] underline italic" href="/authors/karen-jacobson-sive">Karen Jacobson-Sive</a></div><a href="/view/crispr-cas9-gene-therapy-holds-promise-to-treat-epidermolysis-bullosa"><div class="mt-2 ml-4"></div><div class="flex flex-row gap-2"></div><p class=" text-sm text-gray-500 py-1 sm:pl-4">An exon-skipping technique using dual single-guide RNA/Cas9 ribonucleoproteins targeted at 3 novel COL7A1 exons with pathogenic heterozygous mutations achieved exon deletion rates of up to 95%. </p><div class="pl-4"></div></a><div class="flex flex-col sm:flex-row pl-2 mt-4"></div></div></div></div></div></div><div class="w-full h-full"><hr class="mt-1 w-full " style="border-top-width:2px;border-top-color:#F3F4F6"/><div class="w-full h-full"><div class="flex flex-col sm:flex-row justify-center align-center w-100% "><div class="flex flex-col justify-center sm:flex-row py-4 " style="background-color:transparent;border-color:#F3F4F6;border-width:0;border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem"><a href="/view/hct-outcomes-show-improvement-with-posttransplant-cyclophosphamide"><div class="sm:w-[288px] h-100% mt-2"><div class=""><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;padding-top:60.66666666666667%"></span><img alt="stem cell transplant | Image Credit: Vadim-stock.adobe.com.jpeg" title="stem cell transplant | Image Credit: Vadim-stock.adobe.com.jpeg" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="responsive" class="shrink-0" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="stem cell transplant | Image Credit: Vadim-stock.adobe.com.jpeg" title="stem cell transplant | Image Credit: Vadim-stock.adobe.com.jpeg" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F901a62354603f2ad67527c22f772f5a12a3bf928-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=75 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F901a62354603f2ad67527c22f772f5a12a3bf928-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=75 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F901a62354603f2ad67527c22f772f5a12a3bf928-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=75 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F901a62354603f2ad67527c22f772f5a12a3bf928-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=75 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F901a62354603f2ad67527c22f772f5a12a3bf928-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=75 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F901a62354603f2ad67527c22f772f5a12a3bf928-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=75 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F901a62354603f2ad67527c22f772f5a12a3bf928-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F901a62354603f2ad67527c22f772f5a12a3bf928-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F901a62354603f2ad67527c22f772f5a12a3bf928-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="responsive" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="shrink-0" loading="lazy"/></noscript></span></div></div></a><div class="flex-auto w-auto sm:ml-8 flex-1"><span class="text-sm text-gray-500 italic sm:pl-4">July 28th 2024</span><p class="font-bold text-[1rem] sm:pl-4 text-undefined" style="font-size:1.125rem"><a href="/view/hct-outcomes-show-improvement-with-posttransplant-cyclophosphamide">HCT Outcomes Show Improvement With Posttransplant Cyclophosphamide</a></p><div class=" sm:pl-4"><a class="text-sm text-[#00ADEF] underline italic" href="/authors/karen-jacobson-sive">Karen Jacobson-Sive</a></div><a href="/view/hct-outcomes-show-improvement-with-posttransplant-cyclophosphamide"><div class="mt-2 ml-4"></div><div class="flex flex-row gap-2"></div><p class=" text-sm text-gray-500 py-1 sm:pl-4">Post–hematopoietic cell transplantation (HCT) prophylaxis using cyclophosphamide to stave off graft-vs-host disease had positive results compared with calcineurin inhibitor–based prophylaxis, regardless of whether the patient had a matched or unmatched donor.</p><div class="pl-4"></div></a><div class="flex flex-col sm:flex-row pl-2 mt-4"></div></div></div></div></div></div><div class="w-full h-full"><hr class="mt-1 w-full " style="border-top-width:2px;border-top-color:#F3F4F6"/><div class="w-full h-full"><div class="flex flex-col sm:flex-row justify-center align-center w-100% "><div class="flex flex-col justify-center sm:flex-row py-4 " style="background-color:transparent;border-color:#F3F4F6;border-width:0;border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem"><a href="/view/high-costs-hospitalizations-linked-to-ph-ild"><div class="sm:w-[288px] h-100% mt-2"><div class=""><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;padding-top:60.66666666666667%"></span><img alt="doc reviewing lung report | Image Credit: meeboonstudio-stock.adobe.com" title="doc reviewing lung report | Image Credit: meeboonstudio-stock.adobe.com" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="responsive" class="shrink-0" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="doc reviewing lung report | Image Credit: meeboonstudio-stock.adobe.com" title="doc reviewing lung report | Image Credit: meeboonstudio-stock.adobe.com" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F877b0bbc24b826cebff91a2ed1be5d858fe976a1-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=75 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F877b0bbc24b826cebff91a2ed1be5d858fe976a1-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=75 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F877b0bbc24b826cebff91a2ed1be5d858fe976a1-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=75 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F877b0bbc24b826cebff91a2ed1be5d858fe976a1-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=75 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F877b0bbc24b826cebff91a2ed1be5d858fe976a1-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=75 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F877b0bbc24b826cebff91a2ed1be5d858fe976a1-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=75 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F877b0bbc24b826cebff91a2ed1be5d858fe976a1-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F877b0bbc24b826cebff91a2ed1be5d858fe976a1-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F877b0bbc24b826cebff91a2ed1be5d858fe976a1-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="responsive" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="shrink-0" loading="lazy"/></noscript></span></div></div></a><div class="flex-auto w-auto sm:ml-8 flex-1"><span class="text-sm text-gray-500 italic sm:pl-4">July 28th 2024</span><p class="font-bold text-[1rem] sm:pl-4 text-undefined" style="font-size:1.125rem"><a href="/view/high-costs-hospitalizations-linked-to-ph-ild">High Costs, Hospitalizations Linked to PH, ILD</a></p><div class=" sm:pl-4"><a class="text-sm text-[#00ADEF] underline italic" href="/authors/karen-jacobson-sive">Karen Jacobson-Sive</a></div><a href="/view/high-costs-hospitalizations-linked-to-ph-ild"><div class="mt-2 ml-4"></div><div class="flex flex-row gap-2"></div><p class=" text-sm text-gray-500 py-1 sm:pl-4">The hospitalization rate for patients with pulmonary hypertension (PH) and interstitial lung disease (ILD) doubled over a 2-year period, and total health care costs more than doubled over the same period. </p><div class="pl-4"></div></a><div class="flex flex-col sm:flex-row pl-2 mt-4"></div></div></div></div></div></div><div class="w-full h-full"><hr class="mt-1 w-full " style="border-top-width:2px;border-top-color:#F3F4F6"/><div class="flex md:hidden justify-center items-center"></div><div class="w-full h-full"><div class="flex flex-col sm:flex-row justify-center align-center w-100% "><div class="flex flex-col justify-center sm:flex-row py-4 " style="background-color:transparent;border-color:#F3F4F6;border-width:0;border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem"><a href="/view/cpx-351-effective-in-aml-possibly-with-reduced-cardiotoxicity-vs-standard-anthracyclines"><div class="sm:w-[288px] h-100% mt-2"><div class=""><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;padding-top:66.015625%"></span><img alt="AML cells | Image credit: Laszlo - stock.adobe.com" title="AML cells | Image credit: Laszlo - stock.adobe.com" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="responsive" class="shrink-0" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="AML cells | Image credit: Laszlo - stock.adobe.com" title="AML cells | Image credit: Laszlo - stock.adobe.com" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fdf1dffa221627f6732548de65c9b71846a304970-1280x845.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=75 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fdf1dffa221627f6732548de65c9b71846a304970-1280x845.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=75 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fdf1dffa221627f6732548de65c9b71846a304970-1280x845.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=75 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fdf1dffa221627f6732548de65c9b71846a304970-1280x845.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=75 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fdf1dffa221627f6732548de65c9b71846a304970-1280x845.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=75 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fdf1dffa221627f6732548de65c9b71846a304970-1280x845.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=75 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fdf1dffa221627f6732548de65c9b71846a304970-1280x845.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fdf1dffa221627f6732548de65c9b71846a304970-1280x845.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fdf1dffa221627f6732548de65c9b71846a304970-1280x845.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="responsive" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="shrink-0" loading="lazy"/></noscript></span></div></div></a><div class="flex-auto w-auto sm:ml-8 flex-1"><span class="text-sm text-gray-500 italic sm:pl-4">July 15th 2024</span><p class="font-bold text-[1rem] sm:pl-4 text-undefined" style="font-size:1.125rem"><a href="/view/cpx-351-effective-in-aml-possibly-with-reduced-cardiotoxicity-vs-standard-anthracyclines">CPX-351 Effective in AML, Possibly With Reduced Cardiotoxicity vs Standard Anthracyclines</a></p><div class=" sm:pl-4"><a class="text-sm text-[#00ADEF] underline italic" href="/authors/karen-jacobson-sive">Karen Jacobson-Sive</a></div><a href="/view/cpx-351-effective-in-aml-possibly-with-reduced-cardiotoxicity-vs-standard-anthracyclines"><div class="mt-2 ml-4"></div><div class="flex flex-row gap-2"></div><p class=" text-sm text-gray-500 py-1 sm:pl-4">Liposomal daunorubicin and cytarabine (CPX-351) was effective in relapsed acute myeloid leukemia, but long-term follow-up is needed to determine the extent of the agent's cardiotoxicity. </p><div class="pl-4"></div></a><div class="flex flex-col sm:flex-row pl-2 mt-4"></div></div></div></div></div></div><div class="w-full h-full"><hr class="mt-1 w-full " style="border-top-width:2px;border-top-color:#F3F4F6"/><div class="w-full h-full"><div class="flex flex-col sm:flex-row justify-center align-center w-100% "><div class="flex flex-col justify-center sm:flex-row py-4 " style="background-color:transparent;border-color:#F3F4F6;border-width:0;border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem"><a href="/view/study-finds-pirtobrutinib-associated-with-improved-outcomes-vs-venetoclax-in-relapsed-cll"><div class="sm:w-[288px] h-100% mt-2"><div class=""><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;padding-top:66.66666666666666%"></span><img alt="CLL cells | Image credit: Laszlo - stock.adobe.com" title="CLL cells | Image credit: Laszlo - stock.adobe.com" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="responsive" class="shrink-0" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="CLL cells | Image credit: Laszlo - stock.adobe.com" title="CLL cells | Image credit: Laszlo - stock.adobe.com" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F25522052a2c51d8713921072b1256a81c1576daf-1200x800.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=75 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F25522052a2c51d8713921072b1256a81c1576daf-1200x800.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=75 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F25522052a2c51d8713921072b1256a81c1576daf-1200x800.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=75 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F25522052a2c51d8713921072b1256a81c1576daf-1200x800.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=75 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F25522052a2c51d8713921072b1256a81c1576daf-1200x800.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=75 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F25522052a2c51d8713921072b1256a81c1576daf-1200x800.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=75 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F25522052a2c51d8713921072b1256a81c1576daf-1200x800.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F25522052a2c51d8713921072b1256a81c1576daf-1200x800.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F25522052a2c51d8713921072b1256a81c1576daf-1200x800.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="responsive" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="shrink-0" loading="lazy"/></noscript></span></div></div></a><div class="flex-auto w-auto sm:ml-8 flex-1"><span class="text-sm text-gray-500 italic sm:pl-4">July 13th 2024</span><p class="font-bold text-[1rem] sm:pl-4 text-undefined" style="font-size:1.125rem"><a href="/view/study-finds-pirtobrutinib-associated-with-improved-outcomes-vs-venetoclax-in-relapsed-cll">Study Finds Pirtobrutinib Associated With Improved Outcomes vs Venetoclax in Relapsed CLL</a></p><div class=" sm:pl-4"><a class="text-sm text-[#00ADEF] underline italic" href="/authors/karen-jacobson-sive">Karen Jacobson-Sive</a></div><a href="/view/study-finds-pirtobrutinib-associated-with-improved-outcomes-vs-venetoclax-in-relapsed-cll"><div class="mt-2 ml-4"></div><div class="flex flex-row gap-2"></div><p class=" text-sm text-gray-500 py-1 sm:pl-4">Pirtobrutinib led to improved outcomes compared with venetoclax in patients with relapsed chronic lymphocytic leukemia (CLL) following covalent Bruton tyrosine kinase inhibitor therapy. </p><div class="pl-4"></div></a><div class="flex flex-col sm:flex-row pl-2 mt-4"></div></div></div></div></div></div><div class="w-full h-full"><hr class="mt-1 w-full " style="border-top-width:2px;border-top-color:#F3F4F6"/><div class="w-full h-full"><div class="flex flex-col sm:flex-row justify-center align-center w-100% "><div class="flex flex-col justify-center sm:flex-row py-4 " style="background-color:transparent;border-color:#F3F4F6;border-width:0;border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem"><a href="/view/zanubrutinib-safer-than-ibrutinib-in-patients-with-b-cell-malignancies"><div class="sm:w-[288px] h-100% mt-2"><div class=""><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;padding-top:60.66666666666667%"></span><img alt="zanubrutinib | Image Credit: molekuul.be-stock.adobe.com" title="zanubrutinib | Image Credit: molekuul.be-stock.adobe.com" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="responsive" class="shrink-0" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="zanubrutinib | Image Credit: molekuul.be-stock.adobe.com" title="zanubrutinib | Image Credit: molekuul.be-stock.adobe.com" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F3aecd6dec992ed0c9147f4fc93e5c2c50623fa9d-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=75 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F3aecd6dec992ed0c9147f4fc93e5c2c50623fa9d-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=75 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F3aecd6dec992ed0c9147f4fc93e5c2c50623fa9d-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=75 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F3aecd6dec992ed0c9147f4fc93e5c2c50623fa9d-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=75 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F3aecd6dec992ed0c9147f4fc93e5c2c50623fa9d-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=75 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F3aecd6dec992ed0c9147f4fc93e5c2c50623fa9d-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=75 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F3aecd6dec992ed0c9147f4fc93e5c2c50623fa9d-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F3aecd6dec992ed0c9147f4fc93e5c2c50623fa9d-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F3aecd6dec992ed0c9147f4fc93e5c2c50623fa9d-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="responsive" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="shrink-0" loading="lazy"/></noscript></span></div></div></a><div class="flex-auto w-auto sm:ml-8 flex-1"><span class="text-sm text-gray-500 italic sm:pl-4">July 10th 2024</span><p class="font-bold text-[1rem] sm:pl-4 text-undefined" style="font-size:1.125rem"><a href="/view/zanubrutinib-safer-than-ibrutinib-in-patients-with-b-cell-malignancies">Zanubrutinib Safer Than Ibrutinib in Patients With B-Cell Malignancies</a></p><div class=" sm:pl-4"><a class="text-sm text-[#00ADEF] underline italic" href="/authors/karen-jacobson-sive">Karen Jacobson-Sive</a></div><a href="/view/zanubrutinib-safer-than-ibrutinib-in-patients-with-b-cell-malignancies"><div class="mt-2 ml-4"></div><div class="flex flex-row gap-2"></div><p class=" text-sm text-gray-500 py-1 sm:pl-4">A post-hoc analysis showed that zanubrutinib resulted in fewer adverse events compared with ibrutinib. </p><div class="pl-4"></div></a><div class="flex flex-col sm:flex-row pl-2 mt-4"></div></div></div></div></div></div><div class="w-full h-full"><hr class="mt-1 w-full " style="border-top-width:2px;border-top-color:#F3F4F6"/><div class="w-full h-full"><div class="flex flex-col sm:flex-row justify-center align-center w-100% "><div class="flex flex-col justify-center sm:flex-row py-4 " style="background-color:transparent;border-color:#F3F4F6;border-width:0;border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem"><a href="/view/study-to-quantify-non-hodgkin-lymphoma-risk-in-hiv"><div class="sm:w-[288px] h-100% mt-2"><div class=""><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;padding-top:60.66666666666667%"></span><img alt="non-Hodgkin lymphoma | Image Credit: MQ-Illustrations-stock.adobe.com" title="non-Hodgkin lymphoma | Image Credit: MQ-Illustrations-stock.adobe.com" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="responsive" class="shrink-0" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="non-Hodgkin lymphoma | Image Credit: MQ-Illustrations-stock.adobe.com" title="non-Hodgkin lymphoma | Image Credit: MQ-Illustrations-stock.adobe.com" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F010ed192a482703b2eb80f0fcb19407b06ab504b-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=75 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F010ed192a482703b2eb80f0fcb19407b06ab504b-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=75 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F010ed192a482703b2eb80f0fcb19407b06ab504b-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=75 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F010ed192a482703b2eb80f0fcb19407b06ab504b-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=75 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F010ed192a482703b2eb80f0fcb19407b06ab504b-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=75 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F010ed192a482703b2eb80f0fcb19407b06ab504b-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=75 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F010ed192a482703b2eb80f0fcb19407b06ab504b-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F010ed192a482703b2eb80f0fcb19407b06ab504b-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F010ed192a482703b2eb80f0fcb19407b06ab504b-1200x728.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="responsive" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="shrink-0" loading="lazy"/></noscript></span></div></div></a><div class="flex-auto w-auto sm:ml-8 flex-1"><span class="text-sm text-gray-500 italic sm:pl-4">July 6th 2024</span><p class="font-bold text-[1rem] sm:pl-4 text-undefined" style="font-size:1.125rem"><a href="/view/study-to-quantify-non-hodgkin-lymphoma-risk-in-hiv">Study to Quantify Non-Hodgkin Lymphoma Risk in HIV</a></p><div class=" sm:pl-4"><a class="text-sm text-[#00ADEF] underline italic" href="/authors/karen-jacobson-sive">Karen Jacobson-Sive</a></div><a href="/view/study-to-quantify-non-hodgkin-lymphoma-risk-in-hiv"><div class="mt-2 ml-4"></div><div class="flex flex-row gap-2"></div><p class=" text-sm text-gray-500 py-1 sm:pl-4">This meta-analysis study will estimate the global and regional burden of HIV-associated non-Hodgkin lymphoma to aid the development of prevention and control strategies.</p><div class="pl-4"></div></a><div class="flex flex-col sm:flex-row pl-2 mt-4"></div></div></div></div></div></div><div class="w-full h-full"><hr class="mt-1 w-full " style="border-top-width:2px;border-top-color:#F3F4F6"/><div class="w-full h-full"><div class="flex flex-col sm:flex-row justify-center align-center w-100% "><div class="flex flex-col justify-center sm:flex-row py-4 " style="background-color:transparent;border-color:#F3F4F6;border-width:0;border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem"><a href="/view/treatment-patterns-in-patients-with-myasthenia-gravis-are-consistent-between-us-and-italy"><div class="sm:w-[288px] h-100% mt-2"><div class=""><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;padding-top:66.640625%"></span><img alt="Doctor speaking with patient | Image credit: Liudmila Dutko - stock.adobe.com" title="Doctor speaking with patient | Image credit: Liudmila Dutko - stock.adobe.com" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="responsive" class="shrink-0" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="Doctor speaking with patient | Image credit: Liudmila Dutko - stock.adobe.com" title="Doctor speaking with patient | Image credit: Liudmila Dutko - stock.adobe.com" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F63d55e2174626ac71418b0c1519594ab8b211fdd-1280x853.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=75 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F63d55e2174626ac71418b0c1519594ab8b211fdd-1280x853.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=75 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F63d55e2174626ac71418b0c1519594ab8b211fdd-1280x853.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=75 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F63d55e2174626ac71418b0c1519594ab8b211fdd-1280x853.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=75 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F63d55e2174626ac71418b0c1519594ab8b211fdd-1280x853.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=75 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F63d55e2174626ac71418b0c1519594ab8b211fdd-1280x853.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=75 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F63d55e2174626ac71418b0c1519594ab8b211fdd-1280x853.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F63d55e2174626ac71418b0c1519594ab8b211fdd-1280x853.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F63d55e2174626ac71418b0c1519594ab8b211fdd-1280x853.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="responsive" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="shrink-0" loading="lazy"/></noscript></span></div></div></a><div class="flex-auto w-auto sm:ml-8 flex-1"><span class="text-sm text-gray-500 italic sm:pl-4">July 4th 2024</span><p class="font-bold text-[1rem] sm:pl-4 text-undefined" style="font-size:1.125rem"><a href="/view/treatment-patterns-in-patients-with-myasthenia-gravis-are-consistent-between-us-and-italy">Treatment Patterns in Patients With Myasthenia Gravis Are Consistent Between US and Italy</a></p><div class=" sm:pl-4"><a class="text-sm text-[#00ADEF] underline italic" href="/authors/karen-jacobson-sive">Karen Jacobson-Sive</a></div><a href="/view/treatment-patterns-in-patients-with-myasthenia-gravis-are-consistent-between-us-and-italy"><div class="mt-2 ml-4"></div><div class="flex flex-row gap-2"></div><p class=" text-sm text-gray-500 py-1 sm:pl-4">Patients with myasthenia gravis who received treatment within a year from diagnosis were generally in accordance with guideline suggestions.</p><div class="pl-4"></div></a><div class="flex flex-col sm:flex-row pl-2 mt-4"></div></div></div></div></div></div><div class="w-full h-full"><hr class="mt-1 w-full " style="border-top-width:2px;border-top-color:#F3F4F6"/><div class="w-full h-full"><div class="flex flex-col sm:flex-row justify-center align-center w-100% "><div class="flex flex-col justify-center sm:flex-row py-4 " style="background-color:transparent;border-color:#F3F4F6;border-width:0;border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem"><a href="/view/study-finds-ravulizumab-effective-in-treating-acetylcholine-receptor-positive-generalized-mg"><div class="sm:w-[288px] h-100% mt-2"><div class=""><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;padding-top:60.333333333333336%"></span><img alt="Myasthenia gravis | Image Credit: © Andrii - stock.adobe.com" title="Myasthenia gravis | Image Credit: © Andrii - stock.adobe.com" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="responsive" class="shrink-0" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="Myasthenia gravis | Image Credit: © Andrii - stock.adobe.com" title="Myasthenia gravis | Image Credit: © Andrii - stock.adobe.com" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F3399bc86d3cb7d98424f2d54457106359d3b74a2-1200x724.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=75 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F3399bc86d3cb7d98424f2d54457106359d3b74a2-1200x724.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=75 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F3399bc86d3cb7d98424f2d54457106359d3b74a2-1200x724.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=75 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F3399bc86d3cb7d98424f2d54457106359d3b74a2-1200x724.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=75 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F3399bc86d3cb7d98424f2d54457106359d3b74a2-1200x724.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=75 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F3399bc86d3cb7d98424f2d54457106359d3b74a2-1200x724.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=75 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F3399bc86d3cb7d98424f2d54457106359d3b74a2-1200x724.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F3399bc86d3cb7d98424f2d54457106359d3b74a2-1200x724.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F3399bc86d3cb7d98424f2d54457106359d3b74a2-1200x724.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="responsive" style="border-top-left-radius:0rem;border-top-right-radius:0rem;border-bottom-left-radius:0rem;border-bottom-right-radius:0rem;position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="shrink-0" loading="lazy"/></noscript></span></div></div></a><div class="flex-auto w-auto sm:ml-8 flex-1"><span class="text-sm text-gray-500 italic sm:pl-4">July 2nd 2024</span><p class="font-bold text-[1rem] sm:pl-4 text-undefined" style="font-size:1.125rem"><a href="/view/study-finds-ravulizumab-effective-in-treating-acetylcholine-receptor-positive-generalized-mg">Study Finds Ravulizumab Effective in Treating Acetylcholine Receptor–Positive Generalized MG</a></p><div class=" sm:pl-4"><a class="text-sm text-[#00ADEF] underline italic" href="/authors/karen-jacobson-sive">Karen Jacobson-Sive</a></div><a href="/view/study-finds-ravulizumab-effective-in-treating-acetylcholine-receptor-positive-generalized-mg"><div class="mt-2 ml-4"></div><div class="flex flex-row gap-2"></div><p class=" text-sm text-gray-500 py-1 sm:pl-4">More than 60% of complement inhibitor–naive patients with acetylcholine receptor–positive generalized myasthenia gravis (MG) in diverse clinical populations had a clinically meaningful reduction in MG activities of daily living scores.</p><div class="pl-4"></div></a><div class="flex flex-col sm:flex-row pl-2 mt-4"></div></div></div></div></div></div></div><div class="w-full text-center flex justify-center pb-24"><a class="px-4 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","_key":"ab19c0597360"}],"_type":"block","style":"normal","_key":"75a54d3e9100"},{"widthP":30,"disableTextWrap":false,"alt":"FDA approval with stamp. | Image Credit: Surendra - stock.adobe.com","alignment":"right","asset":{"_ref":"image-ca845f7e6dfc35ab2f006b74744bb6c3a34fff11-5500x4093-jpg","_type":"reference"},"disableLightBox":true,"_type":"figure","imgcaption":[{"_type":"block","style":"normal","_key":"a067baf383a9","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The AUGMENT-101 study showed a 21.2% complete remission rate with a median duration of 6.4 months.","_key":"fc66d38024f00"}]},{"children":[{"_type":"span","marks":[],"text":"Image Credit: Surendra - stock.adobe.com","_key":"7383d15cd9ce0"}],"_type":"block","style":"normal","_key":"fca696b1ae87","markDefs":[]}],"_key":"7ee0b2c1ded7"},{"_type":"block","style":"normal","_key":"b1b9e2f40530","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The FDA has approved revumenib (Revuforj) for the treatment of adult and pediatric patients aged 1 year and older with relapsed or refractory acute leukemia and a ","_key":"64a870eb73c20"},{"_type":"span","marks":["em"],"text":"KMT2A","_key":"64a870eb73c21"},{"_type":"span","marks":[],"text":" translocation.","_key":"64a870eb73c22"},{"_type":"span","marks":["superscript"],"text":"1,2","_key":"481cf1ebac26"}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Data from the phase 1/2 AUGMENT-101 study (SNDX-5613-0700; NCT04065399) showed that the menin inhibitor (n = 104) led to a complete remission (CR) plus CR with partial hematologic recovery (CRh; CR+CRh) rate of 21.2% (95% CI, 13.8%-30.3%) with a median duration of CR+CRh of 6.4 months (95% CI, 2.7-not estimable [NE]). In the patients who achieved a CR or CRh with revumenib (n = 22), the median time to response was 1.9 months (range, 0.9-5.6).","_key":"5fbd664ed9790"}],"_type":"block","style":"normal","_key":"88fafc22b989"},{"markDefs":[],"children":[{"marks":[],"text":"Moreover, 14% of 83 patients who were dependent on red blood cell (RBC) and platelet transfusions at baseline achieved independence during any 56-day post-baseline period, and 48% of 21 patients who were independent at baseline remained independent.","_key":"58283f709cee0","_type":"span"}],"_type":"block","style":"normal","_key":"ea2a79ce7b2f"},{"_key":"01303d417a94","markDefs":[],"children":[{"_type":"span","marks":[],"text":"\"The FDA approval of the first menin inhibitor is a major breakthrough for patients with R/R acute leukemia with a KMT2A translocation, a genetic alteration associated with a very poor prognosis,\" Ghayas C. Issa, MD, associate professor of leukemia at The University of Texas MD Anderson Cancer Center, stated in a news release.","_key":"7f590bcc55210"},{"_key":"03a636a59bd9","_type":"span","marks":["superscript"],"text":"3"},{"_type":"span","marks":[],"text":" \"The significant clinical benefit and robust efficacy seen with Revuforj represents a substantial improvement over what has been historically observed in these patients with previously available therapies and has the potential to be an important new treatment option for patients.\"","_key":"3e163ccac259"}],"_type":"block","style":"normal"},{"style":"h2","_key":"caf56161dc85","markDefs":[],"children":[{"_type":"span","marks":[],"text":"About AUGMENT-101: Eligibility, Treatment, Objectives","_key":"c5baa97694080"}],"_type":"block"},{"style":"normal","_key":"4be4a82a9b71","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The single-arm cohort of an open-label, multicenter trial enrolled adult and pediatric patients at least 30 days old who had relapsed or refractory acute leukemia harboring a ","_key":"60efbe4b7b400"},{"_type":"span","marks":["em"],"text":"KMT2A","_key":"60efbe4b7b401"},{"_type":"span","marks":[],"text":" translocation.","_key":"60efbe4b7b402"},{"_type":"span","marks":["superscript"],"text":"2","_key":"3fc3c488e08a"},{"_type":"span","marks":[],"text":" To be eligible, patients needed to have a corrected QT interval of less than 450 milliseconds. Those with an 11q23 partial tandem duplication were not permitted.","_key":"1ce489011e54"}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Revumenib was administered at a dose that was approximately equivalent to 160 mg in adults orally twice daily with a strong CYP3A4 inhibitor. Treatment continued until progressive disease, intolerable toxicity, failure to achieve a morphological leukemia-free state by 4 cycles of treatment, or hematopoietic stem cell transplantation.","_key":"d01dd4e423a70"}],"_type":"block","style":"normal","_key":"d0ab137320ee"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"The primary end point was CR+CRh rate.","_key":"86a8313307100"}],"_type":"block","style":"normal","_key":"1e5889fb6f65"},{"children":[{"_key":"94a09963addd0","_type":"span","marks":[],"text":"Diving Into Demographic and Disease Characteristics"}],"_type":"block","style":"h2","_key":"eccf2043bd64","markDefs":[]},{"_type":"block","style":"normal","_key":"4c9d30a6a9d4","markDefs":[],"children":[{"_type":"span","marks":[],"text":"In the cohort (n = 114) median patient age was 37 years (range, 1-79), with 24% younger than 17 years. More than half of the patients (64%) were female and most were White (72%) and not Hispanic or Latino (73%). Eighty-three percent of patients had AML, 15% had acute lymphoblastic leukemia, and 2% had mixed phenotype acute leukemia.","_key":"31ccd06ff1bd0"}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Moreover, 22%, 19%, 10%, 10%, 7%, 3%, 2%, 2%, and 1% of patients had t(9;11), t(11;19), t(6;11), t(10;11), t(4;11), t(1;11), t(11;17), t(11;22), and t(11;16), respectively. Twenty-five percent of patients had an unknown ","_key":"403fe5978d4d0"},{"_type":"span","marks":["em"],"text":"KMT2A","_key":"403fe5978d4d1"},{"_key":"403fe5978d4d2","_type":"span","marks":[],"text":" fusion partner. 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Additional findings showed that 12.5% (95% CI, 6.8%-20.4%) of patients achieved a CR and the median duration of CR was 4.3 months (95% CI, 1.0-NE). The CRh rate was 8.7% (95% CI, 4.0%-15.8%) and the median duration of CRh was 6.4 months (95% CI, 1.9-NE).","_key":"cdb806484d0c0","_type":"span"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_key":"6e0c2b23b6950","_type":"span","marks":[],"text":"Subgroup analysis revealed that CR+CRh was achieved in 21%, 19%, and 50% of patients with AML (n = 18/86), ALL (n = 3/16), and MPAL (n = 1/2), respectively."}],"_type":"block","style":"normal","_key":"c6611d7571c6"},{"_key":"4d84d2fec6e5","markDefs":[],"children":[{"text":"Shedding Light on Safety","_key":"1d36479124190","_type":"span","marks":[]}],"_type":"block","style":"h2"},{"_type":"block","style":"normal","_key":"cf2f62aae15b","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The safety of revumenib was examined in 104 adult patients and 31 pediatric patients with relapsed or refractory acute leukemia and a ","_key":"ff02a9a9125c0"},{"_type":"span","marks":["em"],"text":"KMT2A","_key":"ff02a9a9125c1"},{"marks":[],"text":" translocation. 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Accessed November 15, 2024. https://ir.syndax.com/news-releases/news-release-details/syndax-announces-fda-approval-revuforjr-revumenib-first-and-only"}]}],"authors":[{"displayName":"Kristi Rosa","url":"kristi-rosa"}],"factCheckAuthors":null,"contentCategory":{"_ref":"3f4b3ced-7c9d-4fc4-967f-fe993087cce2","_type":"reference"},"gptSummary":"The FDA has approved revumenib for treating relapsed or refractory acute leukemia with KMT2A translocation in patients aged 1 year and older. The phase 1/2 AUGMENT-101 study demonstrated a 21.2% complete remission rate with a median duration of 6.4 months. Additionally, 14% of patients achieved independence from red blood cell and platelet transfusions. Common adverse effects included hemorrhage, nausea, increased phosphate levels, and musculoskeletal pain. 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Although critics have argued this exacerbates primary care shortages and inflates health care costs, hospitals have found financial incentives in attracting wealthy patients and securing referrals. With patients willing to pay for personalized care, concierge physician care has raised questions about health care equity and access for underserved populations."}]},{"children":[{"_type":"span","marks":[],"text":"","_key":"1c6fe15ee5050"}],"_type":"block","style":"normal","_key":"1efe86acc6d7","markDefs":[]},{"_type":"block","style":"normal","_key":"126afcde543e","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"Kaiser Permanente Backs Venture Habitat Health","_key":"63ec7b5b042b0"}]},{"style":"normal","_key":"adb305b9b0d4","markDefs":[{"nofollow":true,"blank":true,"_type":"link","href":"https://www.fiercehealthcare.com/providers/kaiser-permanente-backed-habitat-health-offer-pace-services-2025","_key":"edd67f1a9a60"}],"children":[{"_type":"span","marks":[],"text":"Habitat Health, a joint venture between Kaiser Permanente, Town Hall Ventures, and New Enterprise Associates, plans to utilize the Program of All-inclusive Care for the Elderly (PACE) model to offer capitated payments from Medicare and Medicaid for elderly care at home, ","_key":"6348541edeb70"},{"marks":["edd67f1a9a60"],"text":"according to Fierce Healthcare","_key":"6348541edeb71","_type":"span"},{"_type":"span","marks":[],"text":". Habitat Health will not begin operating as a PACE organization until it receives full approval from CMS and the California Department of Health Care Services; if it does, it could begin its services in Sacramento and Los Angeles in 2025. 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In this practice, clinicians work 7-day rotations, with handoffs to the oncoming physician conducted via telephone.","_key":"165ffbc9f8710"}],"_type":"block","style":"normal","_key":"3155fc8a729e"},{"_type":"block","style":"normal","_key":"9581ca45a268","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"3bffddc1f7c50"}]},{"children":[{"_type":"span","marks":[],"text":"Those assuming care received an electronic questionnaire on day 2 of their service week, identifying 1 to 2 randomly selected patients who had been admitted 2 to 5 days before their transition. The questionnaire asked whether any diagnoses had changed, and subsequently about descriptions of the original and new diagnoses, respectively.","_key":"38f040345c5b0"}],"_type":"block","style":"normal","_key":"6b138df5fa80","markDefs":[]},{"markDefs":[],"children":[{"_key":"e01d5772ff6c0","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"fbf52149b50b"},{"markDefs":[{"nofollow":true,"blank":true,"_type":"link","href":"https://www.degruyter.com/document/doi/10.1515/dx-2019-0012/html","_key":"ade04150cb9f"}],"children":[{"_type":"span","marks":[],"text":"Cases with a diagnostic change were independently reviewed by 2 physicians using the ","_key":"3de72e51ccca0"},{"_type":"span","marks":["ade04150cb9f"],"text":"Revised Safer Dx Instrument","_key":"3de72e51ccca1"},{"_type":"span","marks":[],"text":" to determine if the changes may be attributed to a diagnostic error.","_key":"3de72e51ccca2"},{"_type":"span","marks":["superscript"],"text":"4 ","_key":"aa9972c961ba"},{"_type":"span","marks":[],"text":"The reviewers also used the National Coordinating Council for Medication Error Reporting and Prevention Index to classify potential harm.","_key":"d342be321972"},{"_type":"span","marks":["superscript"],"text":"1","_key":"4e0542e4f064"}],"_type":"block","style":"normal","_key":"ba635a5476b0"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"3b1cb9b41bcd0"}],"_type":"block","style":"normal","_key":"a97a4da9c190"},{"style":"normal","_key":"9df59dbcff41","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Overall, the reviewers reported the number of diagnostic changes, errors, and the severity of harm. Each study team member independently reviewed the cases and provided open-ended descriptions of the causes of errors. The team members then met to discuss these assessments and generated 4 final labels for the causes of diagnostic errors: missed information from the electronic health record, missed examination finding, failure to order a test or consultation, and failure to consider a diagnosis.","_key":"e7e09cccc8e00"}],"_type":"block"},{"children":[{"_type":"span","marks":[],"text":"","_key":"600d45549c430"}],"_type":"block","style":"normal","_key":"60a0597667df","markDefs":[]},{"style":"normal","_key":"789a0c172c59","markDefs":[],"children":[{"marks":[],"text":"Of 641 questionnaires, 621 (96.9%) were completed by 36 clinicians. Among 1011 patients, 184 (18.2%) had a diagnostic change and 59 (5.8%) were associated with a diagnostic error. The researchers found that the most common cause of error was missed information from the electronic health record (34 of 68; 50.0%).","_key":"51cb5e528d380","_type":"span"}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"d32bf0bef83a0"}],"_type":"block","style":"normal","_key":"baafb27f528b"},{"_key":"bff52bf6f644","markDefs":[],"children":[{"_type":"span","marks":[],"text":"They noted that few errors were associated with harm (10 of 59; 16.9%), and only 1 likely contributed to death. Conversely, most missed diagnoses involved infectious diseases (16 of 59; 27.1%), followed by cardiovascular (15 of 59; 25.4%) and neurologic (7 of 59; 11.8%) conditions.","_key":"dd0abf99e1270"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"d2f68dbbe7390"}],"_type":"block","style":"normal","_key":"f2409297da17"},{"style":"normal","_key":"cf2a85714a71","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The percentage of patients experiencing diagnostic errors was lower than previously reported. The researchers suggested that this discrepancy may stem from the triggers used in previous studies, which may have overestimated error rates. 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With hurricane season fast approaching the states bordering the Gulf of Mexico and Atlantic Ocean, health care professionals need to prepare for treating patients who may not be able to access health care for an indeterminate amount of time. Collaboration and preparation among multiple teams is of paramount importance to addressing natural disasters when it comes to health care.","_key":"42e8009116d80"}],"_type":"block","style":"normal","_key":"2b340d371209","markDefs":[]},{"_key":"2332b789a869","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"8c25fef1e6460"}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"ea20207528cb","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The period from June through December is usually regarded as hurricane season in the Atlantic Ocean and acts as the primary natural disaster that affects the east and southeastern coasts. Hurricanes can leave residents stranded without means of receiving their health care due to flooding, structural damage to their home, or downed trees and cable lines that make streets dangerous to drive on, assuming the patient has a means of transportation at all. According to an article from Texas A\u0026M, it is estimated that only 35% of people in South Carolina who were recommended to evacuate for Hurricane Matthew in 2016 actually left their home.","_key":"0224ef158c700"},{"text":"1","_key":"b68adf7a6233","_type":"span","marks":["superscript"]},{"_type":"span","marks":[],"text":" This can leave a significant number of people in vulnerable situations once a hurricane actually hits, and can lead to a greater number of fatalities.","_key":"948c7db1b403"}]},{"markDefs":[],"children":[{"text":"With so many people likely to be vulnerable, not only to the after effects of the hurricane itself but also when it comes to getting the health care and treatments that they need, with a 33% higher death rate following a hurricane due to contributing factors,","_key":"82b2ce33a1060","_type":"span","marks":[]},{"_key":"159c713914db","_type":"span","marks":["superscript"],"text":"2"},{"_type":"span","marks":[],"text":" it is important that health care officials, government, and health care facilities work together to figure out ways to address the needs of as many people as possible.","_key":"e04443fedd81"}],"_type":"block","style":"normal","_key":"b3a18afe8c82"},{"markDefs":[],"children":[{"text":"Oncology Practices’ Preparations","_key":"be073c97c685","_type":"span","marks":[]}],"_type":"block","style":"h3","_key":"e4de6eb3f3ac"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"After Hurricane Helene moved through the Southeastern US in late September, bringing devastating flooding, Chris Elder, PharmD, BCOP, associate director of pharmacy clinical services at Florida Cancer Specialists \u0026 Research Institute, told ","_key":"588430fad03f"},{"text":"The American Journal of Managed Care","_key":"0937b9e3dad1","_type":"span","marks":["em"]},{"_type":"span","marks":["superscript"],"text":"®","_key":"5dfce5c63d66"},{"text":" (","_key":"d2303c934d4c","_type":"span","marks":[]},{"_type":"span","marks":["em"],"text":"AJMC®","_key":"3c6ff1fc8489"},{"_type":"span","marks":[],"text":") that hurricanes can be hard to prepare for because even if staff know that the storm is coming, fear of the storm is something that both patients and staff have to overcome. Creating proper plans and preparing for the storm is the best form of overcoming that fear.","_key":"479f9c8a3fc5"}],"_type":"block","style":"normal","_key":"5067acabf8c6"},{"_key":"b9ceedaa3edc","markDefs":[],"children":[{"_type":"span","marks":[],"text":"\"That [emergency prep] team is getting together and meeting well in advance of a storm actually coming and walking through strategies and making sure teams are in place,\" said Elder. \"Everyone has their roles established and what they're accountable for, really to help minimize an impact. So that's really our goal: protecting our patients, protecting our staff, as well as our assets, our buildings, and our medications we have stored on site.\"","_key":"4fb0c5f4a482"}],"_type":"block","style":"normal"},{"children":[{"_type":"span","marks":[],"text":"Darrin Owen, pharmacy operations solutions manager at Florida Cancer Specialists \u0026 Research Institute, said that emergency operations plans start to form even before the 96-hour mark, as hurricanes can sometimes make unexpected turns that leave different parts of the state affected compared with what was planned. Generator clinics and battery backups act as assurance to keeping the stock within the clinics safe and prevent them from perishing.","_key":"35445961b025"}],"_type":"block","style":"normal","_key":"da7baa472c95","markDefs":[]},{"_key":"c3ec0a71fa13","markDefs":[],"children":[{"text":"\"We have plans in place for our clinics that do not have generators to transfer their drugs to these locations so we know these drugs are safe during the storm,\" Owen told ","_key":"e0e72fa3f084","_type":"span","marks":[]},{"_type":"span","marks":["em"],"text":"AJMC","_key":"234b0d45caad"},{"_type":"span","marks":[],"text":". \"We won't delay patient care once we're able to assess damage and contact patients and get them back into the clinics.\"","_key":"57ce4f07afa7"}],"_type":"block","style":"normal"},{"style":"normal","_key":"7d9319d23cd4","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Owen emphasized that oncology clinics, such as the one he works in, work together with multiple departments within their organization to get patients to their closest clinic to receive their treatment. The ability to move drugs from one place to another is also a beneficial practice in these situations.","_key":"133d7d2030cb"}],"_type":"block"},{"style":"normal","_key":"f3b223c8e821","markDefs":[],"children":[{"_type":"span","marks":[],"text":"\"This past hurricane [Helene], we had a list of drugs that FedEx and UPS had a no-ship zip list so we knew where drugs weren't going to be able to be delivered,\" he said. \"So in an event like that, we can always plan to have it delivered to a different zip code so that way we can get someone to go to that location, pick up the medication, and bring it to wherever we can get the patient.\"","_key":"7bd1eb12b64e"}],"_type":"block"},{"markDefs":[],"children":[{"marks":[],"text":"Elder stated that, with Hurricane Helene, about 70% of clinics were open on Thursday and all returned to fully operational by Monday due to the preparation put in before each hurricane. However, Elder emphasized that they want to make sure patients are not putting themselves in danger when attempting to get to a clinic to get their treatment, stating that patients are often more fearful of the storm than they are about missing treatments.","_key":"b01636295eb1","_type":"span"}],"_type":"block","style":"normal","_key":"192184ea7cf6"},{"_type":"block","style":"normal","_key":"2d6774a1d66c","markDefs":[],"children":[{"_key":"0427d521d8c8","_type":"span","marks":[],"text":"\"We need to empathize with that, recognize that fear that patients may have, and communicate effectively and appropriately to let them know that it's more important that they stay safe and may, at the very worst case, miss a day or so of treatment vs being placed in a dangerous scenario,\" said Elder. \"We want to protect the patients, keep them safe, keep them on schedule as much as we can...but knowing if we need to move them a few days out, that's not going to impact their care.\""}]},{"_key":"a1b56f19b8ce","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Strategies for the Underserved","_key":"3cd495c36579"}],"_type":"block","style":"h3"},{"markDefs":[],"children":[{"marks":[],"text":"Federally qualified health centers (FQHCs) and other clinics that provide care throughout the country are an important resource when it comes to helping patients in low-income areas. FQHCs and other clinics can give extended supplies of medications to their patients to ensure that their patients have enough to last through the natural disaster, even providing methods of keeping perishable medications cool in case of a power outage.","_key":"0f741a24d05d","_type":"span"},{"_type":"span","marks":["superscript"],"text":"2","_key":"c303678b8fea"},{"marks":[],"text":" ","_key":"65b5d4613a27","_type":"span"}],"_type":"block","style":"normal","_key":"7d3b5e6e71c3"},{"markDefs":[],"children":[{"marks":[],"text":"Other methods of making sure patients can maintain contact with their providers included distributing smartphones and remote monitoring tools for patients in the area to ensure the patient is able to request help if they need it. The clinics can also help serve patients that are not their own in case of flooding and other emergencies.","_key":"a46e574afea6","_type":"span"}],"_type":"block","style":"normal","_key":"87e03d866ddf"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Another aspect of care that the FQHCs specifically can address is the care of undocumented immigrants during these emergencies. Undocumented immigrants are less likely to go to clinics for care during emergencies due to a fear of deportation. FQHC staff can attempt travel to areas with the most need in order to encourage patients to get care and give care themselves in order to care for the patients as quickly and effectively as possible.","_key":"07592c0248690"},{"_key":"28db560a946f","_type":"span","marks":["superscript"],"text":"2"}],"_type":"block","style":"normal","_key":"8ee7c4c678a1"},{"_key":"68f5c055342d","markDefs":[],"children":[{"marks":[],"text":"Keeping Hospitals Safe","_key":"758b25e9d96e","_type":"span"}],"_type":"block","style":"h3"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Hospitals also act as facilities that have to prepare for natural disaster. All hospitals require an emergency plan in case of disaster, approved by the hospital’s accrediting body.","_key":"5613c273c2020"},{"_type":"span","marks":["superscript"],"text":"3","_key":"f425f30ec760"},{"_type":"span","marks":[],"text":" These plans are implemented before natural disasters such as hurricanes, with coordination occurring between local government, first responders, and patients. Decisions include deciding whether to evacuate the hospital or have staff remain the hospital throughout the storm. However, transferring patients can have health consequences so these decisions are not taken lightly and are done only in extreme emergencies.","_key":"b9dfc5971cce"}],"_type":"block","style":"normal","_key":"5a791059f87d"},{"style":"normal","_key":"3e770c1a8cce","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Right before natural disasters, patients needing elective surgery will have to wait, as these surgeries are often shut down in favor of utilizing resources solely on disaster relief and taking care of patients already admitted to the hospital.","_key":"1e24e30bd40f0"},{"_type":"span","marks":["superscript"],"text":"3","_key":"9382c5f0a91e"},{"text":" This includes making sure that there are 2 teams of health care professionals available to treat patients and able to relieve each other of work.","_key":"4aa7b43c3fb6","_type":"span","marks":[]}],"_type":"block"},{"markDefs":[],"children":[{"text":"Emergency plans for hurricanes include making sure that there is air conditioning for patient comfort, backup power for equipment keeping patients alive, and having enough food, water, and medicine in case of supply chain issues or difficulty in getting supplies to the hospital. This is vital when it comes to continuing to care for the patients within the care of the hospital.","_key":"e79c7ce1d5bc0","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"54205f2639ae"},{"_type":"block","style":"normal","_key":"a7aa433ac922","markDefs":[],"children":[{"text":"\"Knowing that [hurricanes] are eventually going to happen during hurricane season for us, it's always best to have a plan in place,\" said Owen. \"We know, in most cases, health care providers and patients are most likely to be displaced after natural disaster, so it's in our best interest to be prepared for them and have a solution ready.\"","_key":"0a8effd81dd8","_type":"span","marks":[]}]},{"_key":"b821fa94b5d1","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Looking Forward","_key":"3b4d750b12e80"}],"_type":"block","style":"h3"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"An important factor when considering preparation in the future is the effect of climate change when it comes to both the extremity of the storms as well as the frequency of the storms. This can include the rising sea level or more frequent wildfires in some areas that can affect the way that residential patients live. Patients who are at a higher risk of being effected by extreme weather events were identified through a dashboard created in 2021.","_key":"1c7b549545e40"},{"marks":["superscript"],"text":"2","_key":"165b8c1d808d","_type":"span"},{"_type":"span","marks":[],"text":" This dashboard includes patients who have cancer, asthma, chronic obstructive pulmonary disease, dementia, and mental illness. The dashboard is able to indicate which regions are most at risk by assessing weather, climate, and air quality data in each region. This can allow for health centers and providers to narrow down who they need to target when it comes to preparation.","_key":"bc5c61294fe6"}],"_type":"block","style":"normal","_key":"2c222a1719f1"},{"_key":"c0535201fc63","asset":{"_ref":"image-6f6723ca96a1ccfd82d7c53cfb0a53bb6f6a2685-6708x4472-jpg","_type":"reference"},"alt":"Hospitals, clinics, and health care workers prepare for hurricanes in advance to make sure all patients receive the care that they need | Image credit: Satoshi Kina - stock.adobe.com","disableLightBox":true,"widthP":40,"_type":"figure","imgcaption":[{"children":[{"_type":"span","marks":[],"text":"Hospitals, clinics, and health care workers prepare for hurricanes in advance to make sure all patients receive the care that they need | Image credit: Satoshi Kina - stock.adobe.com","_key":"1c8102a63b740"}],"_type":"block","style":"normal","_key":"61de1fc1d586","markDefs":[]}],"alignment":"right","disableTextWrap":false},{"_key":"fd1ce511610b","markDefs":[],"children":[{"marks":[],"text":"Climate change is also likely to affect areas of low health equity, due to poorer air quality and lower funding in the area. Targeting these areas as regions to focus on during and outside of natural disasters should be a priority going forward, as reducing the disparities found in these areas could improve overall mortality and strain on health care resources during natural disasters.","_key":"2b720a0503fb0","_type":"span"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"14683fec99ea"}],"_type":"block","style":"normal","_key":"c06bad989c2a"},{"children":[{"_key":"cd8dc004bd81","_type":"span","marks":[],"text":"Elder stated that making sure that all clinics in the state are prepared for the storm, regardless of whether they initially think the storm will affect them or not, is a way for them to keep vigilant and take all of the hurricanes seriously."}],"_type":"block","style":"normal","_key":"a4b3e81307f6","markDefs":[]},{"markDefs":[],"children":[{"_key":"2488b2b4ddc1","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"692eecf1efcc"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Owen addressed this by saying that, for them, the severity of the future hurricanes doesn't materially affect the way that they will prepare for hurricanes in the future. \"We may have to pivot based off of different outliers with the storm...But I really feel that if we just continue moving forward with the plan that we have in place, in improving that plan, I think that's the most we can do,\" he said.","_key":"2131fd4705b3"}],"_type":"block","style":"normal","_key":"e53af4cc38bd"},{"style":"normal","_key":"28a38d39f26c","markDefs":[],"children":[{"text":"","_key":"f1fcb4656110","_type":"span","marks":[]}],"_type":"block"},{"_type":"block","style":"normal","_key":"f753d70e43c5","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Elder said that there are aspects of emergency planning and disaster preparation that can help in day-to-day medical treatment, including effective communication, strategic planning, establishing accountability, and establishing clear roles and responsibilities. ","_key":"ef8dabca839f"}]},{"_type":"block","style":"normal","_key":"f35a1ac2476d","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"2bb809872be2"}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"\"As we know, unfortunately we go through storm season every year and we just had Hurricane Helene. We're already on the lookout for the next storm coming. So any way that we can make improvements will be beneficial,\" said Elder. \"So being able to take those processes and key strategies, we can apply those to the day to day operations to streamline care and be even more effective in delivering cancer care to our patients.\"","_key":"c689a200f909"}],"_type":"block","style":"normal","_key":"98abfdacb30b"},{"_key":"0741cf913d0a","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"9356bfcae116"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"marks":[],"text":"Improving on their plans, according to Owen, could involve doing more outreach in the days following a hurricane, specifically the idea of mobile units being dispatched that could help to administer medication. Pop-up areas around a community could be 1 such option. \"If we could come across something like that in the future to help with this, I think it would definitely improve patient care...During times like this, FEMA goes out and they do their pop-up things for just regular assistance. I could see health care helping with something like that as well,\" he said.","_key":"f8dfdf5d251d","_type":"span"}],"_type":"block","style":"normal","_key":"e90f9e3979ff"},{"_key":"e164514fd535","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"2943b454d98b0"}],"_type":"block","style":"normal"},{"style":"normal","_key":"12017b284804","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Overall, a great deal of preparation is required to get the proper mechanizations in place to care for patients during a natural disaster. Preparing patients by giving them extra supplies of necessary medication, addressing patients who have stayed during a call for evacuation, and helping patients who live in particular areas of need are paramount in making sure that natural disasters do not worsen the health care of patients in affected areas.","_key":"bbee72f3ec6a0"}],"_type":"block"},{"_key":"1218e0c19238","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"618f0922e54d0"}],"_type":"block","style":"normal"},{"style":"normal","_key":"fa98b049767a","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"References","_key":"ece070d7ee560"}],"_type":"block"},{"listItem":"number","markDefs":[],"children":[{"text":"Horney J. Why don’t more people evacuate before hurricanes? Texas A\u0026M Today. October 19, 2016. Accessed September 25, 2024. https://today.tamu.edu/2016/10/19/why-dont-more-people-evacuate-before-hurricanes/","_key":"a86bc96b11870","_type":"span","marks":[]}],"level":1,"_type":"block","style":"normal","_key":"4e9d3ac3dae3"},{"markDefs":[],"children":[{"text":"Hostetter M, Klein S. How health care organizations are preparing for climate shocks and protecting vulnerable patients. The Commonwealth Fund. October 20, 2022. Accessed September 25, 2024. https://www.commonwealthfund.org/publications/2022/oct/how-health-care-organizations-are-preparing-for-climate-shocks","_key":"4d53a72d283a0","_type":"span","marks":[]}],"level":1,"_type":"block","style":"normal","_key":"e9f23b6f775b","listItem":"number"},{"style":"normal","_key":"d551ee8734dc","listItem":"number","markDefs":[],"children":[{"_key":"a06fde1d5e5f0","_type":"span","marks":[],"text":"Hess DB. How do hospitals prepare for hurricanes. CNN Health. September 2, 2019. Accessed September 25, 2024. https://www.cnn.com/2019/09/02/health/hurricane-hospital-prep-partner/index.html"}],"level":1,"_type":"block"}],"is_visible":true,"_createdAt":"2024-09-25T17:29:29Z","ExcludeFromPubMedXML":false,"_type":"article","url":"addressing-natural-disaster-takes-cooperation-preparation-to-ensure-patient-health","summary":"As hurricane season approaches, doctors, pharmacists, and clinics prepare for treating their patients when accessibility is limited.","authorMapping":[{"_type":"reference","_key":"b647ef184b67","_ref":"15b1de57-6a71-4655-ba17-eeaa1c733634"}],"updatedOn":"2024-10-01T14:29:49.147Z","title":"Addressing Natural Disaster Takes Cooperation, Preparation to Ensure Patient Health","articleType":"News","_updatedAt":"2024-10-01T15:09:28Z","thumbnail":{"asset":{"_ref":"image-6f6723ca96a1ccfd82d7c53cfb0a53bb6f6a2685-6708x4472-jpg","_type":"reference"},"_type":"mainImage","alt":"Hurricane | Image credit: Satoshi Kina - stock.adobe.com","caption":"Hurricane | 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packaging | Image credit: Bristol Myers Squibb","caption":"Opdivo packaging | Image credit: Bristol Myers Squibb","asset":{"_ref":"image-020de2a739acebd5b1504eaae11472ee817989eb-880x588-webp","_type":"reference"}},"_rev":"m9zO7fOEUWAduYt5irqLdA","_type":"article","_id":"296e2e2c-9ac3-4e08-9010-08dbb6568960","authors":[{"displayName":"Mary Caffrey","url":"mary-caffrey"}],"ExcludeFromPubMedXML":false,"is_visible":true,"published":"2024-05-09T14:47:58.291Z","summary":"Some experts believe offering a subcutaneous version of nivolumab could make PD-1 inhibitors available to new groups of patients who currently lack access, such as those in rural areas.","factCheckAuthors":null,"seoTag":["nivolumab","subcutaneous","patient access","PD-1 inhibitors"],"contentCategory":{"_ref":"3f4b3ced-7c9d-4fc4-967f-fe993087cce2","_type":"reference"},"_updatedAt":"2024-05-21T13:40:20Z","body":[{"style":"normal","_key":"41703c5983b8","markDefs":[],"children":[{"_type":"span","marks":["em"],"text":"This article has been updated to reflect a revised target action date.","_key":"3d1048e4c5c30"}],"_type":"block"},{"_type":"block","style":"normal","_key":"7f370f4ff381","markDefs":[],"children":[{"_type":"span","marks":[],"text":"FDA has accepted Bristol Myer Squibb’s biologics license application (BLA) for its subcutaneous (SC) formulation of the nivolumab, which company officials say has the “potential” to be the first PD-1 inhibitor administered by subcutaneous injection if approved by its target action date, which has been advanced to December 29, 2024.","_key":"7f7ef136297e"},{"_type":"span","marks":["superscript"],"text":"1,2","_key":"5e1ac0420814"}]},{"_type":"block","style":"normal","_key":"18e69fbb5220","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Sold as Opdivo, the therapy is formulated with hyaluronidase to create subcutaneous (SC) nivolumab. According to a BMS statement, the BLA covers all previously approved indications for use of intravenous (IV) nivolumab as a monotherapy in adult solid tumors, and all approvals for monotherapy as a maintenance therapy following use of the combination nivolumab plus ipilimumab (Yervoy) or combinations with chemotherapy or cabozantinib (Cabometyx).","_key":"982e953e0bc9"}]},{"markDefs":[],"children":[{"marks":[],"text":"Although some warn it’s too soon to say whether the shift to SC nivolumab will be a game-changer, leaders from BMS are enthusiastic about the BLA.","_key":"1a9e7e7466fa","_type":"span"}],"_type":"block","style":"normal","_key":"3d5f65f07a1c"},{"alignment":"left","asset":{"_ref":"image-0e20514b3f4fc8c570e965e47c4c6f01add5d233-500x500-jpg","_type":"reference"},"widthP":15,"_type":"figure","alt":"Gina Fusaro, PhD | Image credit: LinkedIn","imgcaption":[{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Gina Fusaro, PhD | Image credit: LinkedIn","_key":"51e126ab2c89"}],"_type":"block","style":"normal","_key":"e144f8a21dc0"}],"_key":"478d53c3a3cf"},{"_key":"07542976be2c","markDefs":[],"children":[{"_type":"span","marks":[],"text":"“We believe subcutaneous nivolumab has the potential to make a significant difference in the lives of patients, which is reinforced by the FDA’s acceptance of our application,” Gina Fusaro, PhD, vice president, global program lead, BMS, said in the statement. “[Nivolumab] is a foundational PD-1 inhibitor approved for many different types of cancer, and our continued investment in research that puts patients first remains a priority.","_key":"5f1970eb80770"},{"_type":"span","marks":["superscript"],"text":"2","_key":"27ad0cd7acc5"}],"_type":"block","style":"normal"},{"_key":"e3d1c66b344e","markDefs":[],"children":[{"_key":"80e54e1627200","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"marks":[],"text":"“If approved by the FDA, the subcutaneous administration of nivolumab would provide patients and their physicians with a new option that delivers the same well-known benefits as IV [nivolumab] but with the improved convenience of an injection administered in 3-5 minutes rather than a 30-to-60-minute infusion.”","_key":"8f5a196ce910","_type":"span"},{"text":"2","_key":"05c892576860","_type":"span","marks":["superscript"]}],"_type":"block","style":"normal","_key":"9735bb9abae7"},{"_key":"0db4a068b7c7","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The BLA is based on results from CheckMate-67T (NCT04810078), a phase 3 randomized trial that compared SC nivolumab and IV nivolumab in patients with advanced or metastatic clear cell renal cell carcinoma who had received prior systemic therapy. A total of 495 patients were evaluated. Coprimary endpoints are time-averaged serum concentration over 28 days and trough serum concentration at steady-state of SC nivolumab vs IV nivolumab. A key secondary endpoint is objective response rate (ORR).","_key":"f996b9172876"}],"_type":"block","style":"normal"},{"style":"normal","_key":"1b22c24d4e81","markDefs":[{"_type":"link","href":"https://news.bms.com/news/corporate-financial/2024/Bristol-Myers-Squibb-Data-at-ASCO-GU-2024-Showcase-Transformative-Research-in-the-Treatment-of-Genitourinary-Cancers/default.aspx","_key":"2a939bb4d4f7"}],"children":[{"_type":"span","marks":[],"text":"Results were presented earlier this year at the 2024 ","_key":"e75d856725d9"},{"_type":"span","marks":["2a939bb4d4f7"],"text":"American Society of Clinical Oncology Genitourinary Cancers Symposium","_key":"a90c8d4615441"},{"_type":"span","marks":[],"text":" (ASCO GU), where data showed the study met both coprimary pharmacokinetic endpoints and its secondary endpoint of ORR, with response rates of 24.2% (95% CI, 19.0%-30.0%) for subcutaneous nivolumab vs 18.2% (95% CI, 13.6%-23.6%) for IV nivolumab.","_key":"a90c8d4615442"},{"_key":"a81685dca7b2","_type":"span","marks":["superscript"],"text":"3"}],"_type":"block"},{"_type":"block","style":"normal","_key":"95be91e2212c","markDefs":[],"children":[{"_type":"span","marks":[],"text":"A key advantage of subcutaneous nivolumab, and this administration route generally, is the rapid time to give patients the drug. It only takes an average of 5 minutes to administer subcutaneous nivolumab, compared with 30 minutes for IV administration.","_key":"936de3e6729e"}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"The possibility of faster administration times—without the need for an infusion center—could make the PD-1 inhibitor available to patients for whom access is difficult, including those in rural areas, an expert told the National Cancer Institute (NCI) earlier this year.","_key":"9eeb5e9d9c7f"},{"_type":"span","marks":["superscript"],"text":"4","_key":"af13550df66b"}],"_type":"block","style":"normal","_key":"c3765aa36046"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"“Subcutaneous immunotherapy is exciting on many fronts,” Mark Ball, MD, a kidney cancer expert in NCI’s Center for Cancer Research said in March. “We don't know if this is going to end up being a game changer or not, but it definitely has potential.”","_key":"13a92d3cad59"}],"_type":"block","style":"normal","_key":"edee96be7c7a"},{"style":"normal","_key":"9cdfca719c36","markDefs":[],"children":[{"marks":[],"text":"","_key":"e12becc812160","_type":"span"}],"_type":"block"},{"_type":"block","style":"normal","_key":"32e8df0da4c8","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"References","_key":"2fec478258c6"}]},{"_key":"b5da34a7c769","markDefs":[{"_type":"link","href":"https://bit.ly/3K7DO3s","_key":"269afbafbc93"}],"children":[{"text":"1. Bristol Myers Squibb announced updated action date by the U.S. Food and Drug Administration for subcutaneous nivolumab (nivolumab and hyaluronidase). News release. BMS website. Updated and accessed May 21, 2024. ","_key":"4fea97b340cf0","_type":"span","marks":[]},{"text":"https://bit.ly/3K7DO3s","_key":"4fea97b340cf1","_type":"span","marks":["269afbafbc93"]}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"2. U.S. Food and Drug Administration accepts Bristol Myers Squibb’s application for subcutaneous nivolumab (nivolumab and hyaluronidase). News Release. Bristol Myers Squibb. May 8, 2024. Accessed May 6, 2024. https://news.bms.com/news/details/2024/U.S.-Food-and-Drug-Administration-Accepts-Bristol-Myers-Squibbs-Application-for-Subcutaneous-Nivolumab-nivolumab-and-hyaluronidase/default.aspx","_key":"cdbba63c3806"}],"_type":"block","style":"normal","_key":"bb16c3871a55"},{"children":[{"_type":"span","marks":[],"text":"3. George S, Bourlon MT, Chacon MR, et al. Subcutaneous nivolumab (NIVO SC) vs intravenous nivolumab (NIVO IV) in patients with previously treated advanced or metastatic clear cell renal cell carcinoma (ccRCC): pharmacokinetics (PK), efficacy, and safety results from CheckMate 67T. J Clin Oncol. 2024;42(suppl 4). doi:0.1200/JCO.2024.42.4_suppl.LBA360","_key":"2f0e17ecb2f9"}],"_type":"block","style":"normal","_key":"32059f310c10","markDefs":[{"_type":"link","href":"https://www.cancer.gov/news-events/cancer-currents-blog/2024/kidney-cancer-subcutaneous-nivolumab","_key":"0e45310abdd0"}]},{"_type":"block","style":"normal","_key":"82d47c43c516","markDefs":[{"href":"https://www.cancer.gov/news-events/cancer-currents-blog/2024/kidney-cancer-subcutaneous-nivolumab","_key":"0e45310abdd0","_type":"link"}],"children":[{"text":"4. Jaber N. Nivolumab injections could make treatment easier for more people with cancer. National Cancer Institute. March 13, 2024. Accessed May 9, 2024. ","_key":"2f4b7bf1caae","_type":"span","marks":[]},{"text":"https://www.cancer.gov/news-events/cancer-currents-blog/2024/kidney-cancer-subcutaneous-nivolumab","_key":"5bd9cecb00851","_type":"span","marks":["0e45310abdd0"]}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"0efde54391e40"}],"_type":"block","style":"normal","_key":"b3f6d6ce474f"}],"url":"fda-accepts-nivolumab-subcutaneous-injection-application-with-potential-to-boost-access-to-pd-1-inhibitors","title":"FDA Accepts Nivolumab Subcutaneous Injection Application, With Potential to Boost Access to PD-1 Inhibitors","_createdAt":"2024-05-09T14:12:09Z"},{"drugMentions":"{\"drug_mentions\": []}","taxonomyMapping":[{"_updatedAt":"2022-01-19T10:20:16Z","identifier":"news","_createdAt":"2020-03-30T18:05:45Z","parent":null,"_rev":"OU32WOWh4YetHW0RkWbkso","_type":"taxonomy","name":"News","_id":"39be7351-bd4c-4e98-82b3-0d675ae4671b"},{"cmeType":"per","_id":"compendium_ophthalmology","_updatedAt":"2023-11-03T18:18:13Z","summary":[{"_key":"5e609b8c817c","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The ","_key":"173f36e0f212"},{"_key":"af3dae194a6a","_type":"span","marks":["em"],"text":"AJMC"},{"_type":"span","marks":["superscript"],"text":"®","_key":"0cf3c424cf92"},{"_type":"span","marks":[],"text":" Ophthalmology compendium is a comprehensive resource for clinical news and expert insights for treatment of disorders of the eye.","_key":"9148ec8626cd"}],"_type":"block","style":"normal"}],"identifier":"ophthalmology","name":"Ophthalmology","_createdAt":"2020-04-14T15:02:13Z","_rev":"J9E0v654gKdSlGLhTDCoTo","_type":"taxonomy","parent":{"identifier":"compendium","isMainTopic":true,"_createdAt":"2020-03-30T18:16:46Z","_rev":"oruil6rlosjyltJbhrNMGF","_type":"taxonomy","_updatedAt":"2024-04-09T09:14:18Z","name":"Compendium","_id":"297fa3d1-5216-46eb-bf51-66c5f77c3c8a","parent":null},"perKeywordMapping":["Ophthalmology","Health Equity Diversity \u0026 Inclusion"]}],"_updatedAt":"2024-11-22T21:58:57Z","authors":[{"displayName":"Julia Bonavitacola","url":"julia-bonavitacola"}],"ExcludeFromPubMedXML":false,"title":"Polygenic Risk Scores Can Identify Patients Who Should Receive IOP-Lowering Treatment","seoTag":["IOP","PRS","VCDR","glaucoma"],"articleType":"News","updatedOn":null,"gptTakeaways":"• Polygenic risk scores for IOP and VCDR significantly enhance glaucoma risk prediction, especially for primary open-angle glaucoma.\n\n• The study utilized data from multiple cohorts, including the Canadian Longitudinal Study on Aging and UK Biobank.\n\n• PRS explained a substantial variance in IOP and VCDR phenotypes, improving prediction accuracy.\n\n• The PRS was less effective in non-European ancestries, highlighting the need for further research in diverse populations.","is_visible":true,"timeAgo":107900.283,"thumbnail":{"_type":"mainImage","alt":"Glaucoma | Image credit: Alessandro Grandini - stock.adobe.com","caption":"Glaucoma | Image credit: Alessandro Grandini - stock.adobe.com","asset":{"_ref":"image-b20a6f121504080b81c7aaef4069db75606e501c-4415x2077-jpg","_type":"reference"}},"_type":"article","_rev":"qMZkEXqBAV3IRERLMB0rp3","_id":"c147900c-cfbe-4b1d-8aad-45d2dcac4691","published":"2024-11-21T16:00:36.717Z","_createdAt":"2024-11-21T15:50:34Z","summary":"Glaucoma risk can be managed more effectively with the ability to use polygenic risk scores to identify individuals who can benefit from more intense treatment.","authorMapping":[{"_ref":"15b1de57-6a71-4655-ba17-eeaa1c733634","_type":"reference","_key":"e61c5123dda5"}],"factCheckAuthors":null,"gptSummary":"Polygenic risk scores (PRS) for intraocular pressure (IOP) and vertical cup-disc ratio (VCDR) can enhance glaucoma risk prediction, particularly for primary open-angle glaucoma (POAG). The study utilized data from the Canadian Longitudinal Study on Aging, Busselton Healthy Aging Study, and UK Biobank, revealing that PRS significantly explained variance in IOP and VCDR phenotypes. However, the PRS was less predictive in non-European ancestries, indicating a need for further research in diverse populations. The findings suggest PRS could improve early glaucoma diagnosis and management strategies.","url":"polygenic-risk-scores-can-identify-patients-who-should-receive-iop-lowering-treatment","contentCategory":{"_ref":"3f4b3ced-7c9d-4fc4-967f-fe993087cce2","_type":"reference"},"body":[{"markDefs":[{"_type":"link","href":"https://www.ajmc.com/compendium/ophthalmology","_key":"604440543c88","nofollow":false,"blank":true}],"children":[{"_type":"span","marks":[],"text":"An intraocular pressure (IOP) polygenic risk score (PRS) could identify which patients would benefit the most from intensive treatment to lower IOP and manage their risk of ","_key":"452f402cbf7c0"},{"_type":"span","marks":["604440543c88"],"text":"glaucoma","_key":"7cab263ba064"},{"text":", according to a study published in ","_key":"96920c6afff6","_type":"span","marks":[]},{"text":"JAMA Ophthalmology","_key":"452f402cbf7c1","_type":"span","marks":["em"]},{"_key":"452f402cbf7c2","_type":"span","marks":[],"text":"."},{"_type":"span","marks":["superscript"],"text":"1","_key":"4e352fba678a"},{"marks":[],"text":" Vertical cup-disc ratio (VCDR) PRS can also be used to determine the risk of glaucoma, even in patients with normal IOP.","_key":"89d377a2c056","_type":"span"}],"_type":"block","style":"normal","_key":"a27a6e39826f"},{"_key":"ca039f74e1da","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"a2939c2dff270"}],"_type":"block","style":"normal"},{"_key":"47bdcc617935","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Glaucoma is an eye condition that can lead to vision loss and blindness, with the most prevalent form of glaucoma being primary open-angle glaucoma (POAG)","_key":"a598eba7d7370"},{"text":"2","_key":"8cec5a3509a5","_type":"span","marks":["superscript"]},{"text":" at 2.4% global prevalence. IOP and VCDR are 2 of the risk factors for POAG and are necessary in attempting to diagnose the condition early to prevent the worst outcomes in patients. Due to the heritability of IOP and VCDR, a PRS could be beneficial in identifying individuals who are most at risk. This study aimed to assess how PRS can help to identify patients who are at highest risk based ont heir OP and VCDR scores.","_key":"f0107a68c1b4","_type":"span","marks":[]}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"2954d48a54090"}],"_type":"block","style":"normal","_key":"3840269b9a63"},{"children":[{"_type":"span","marks":[],"text":"This study used multiple cohorts from previous studies, including the Canadian Longitudinal Study on Aging (CLSA), the Busselton Healthy Aging Study (BHAS) and the UK Biobank. The CLSA contained data from Canadians aged between 45 and 85 years collected between 2010 and 2015. IOP measurements that compensated for the cornea were calculated for baseline and follow-up in this dataset. Any participant who did not have IOP measurements was excluded.","_key":"71ad2ac800fa0"}],"_type":"block","style":"normal","_key":"6d7f3835e6ed","markDefs":[]},{"_type":"figure","alt":"A PRS may be able to predict the incidence of glaucoma in individuals, allowing for more targeted treatment for these patients | Image credit: Alessandro Grandini - stock.adobe.com","imgcaption":[{"_type":"block","style":"normal","_key":"26d84f7005ea","markDefs":[],"children":[{"_type":"span","marks":[],"text":"A PRS may be able to predict the incidence of glaucoma in individuals, allowing for more targeted treatment for these patients | Image credit: Alessandro Grandini - stock.adobe.com","_key":"682c7441c1840"}]}],"asset":{"_ref":"image-b20a6f121504080b81c7aaef4069db75606e501c-4415x2077-jpg","_type":"reference"},"disableTextWrap":false,"_key":"8ce074520216","alignment":"left","widthP":40,"disableLightBox":true},{"children":[{"_type":"span","marks":[],"text":"The BHAS included participants from Busselton, Western Australia, with data collected from individuals aged 46 to 64 years between 2010 and 2015. There were 4839 individuals for IOP PRS validation and 1588 individuals who had VCDR PRS validation. The UK Biobank was also used for this study and collected data on individuals aged 40 to 69 years from 2006 to 2010 who lived in the UK. Patients with African, East Asian, and South Asian ancestry were included.","_key":"30814a63e47f0"}],"_type":"block","style":"normal","_key":"3a9b9e46d9e4","markDefs":[]},{"_type":"block","style":"normal","_key":"cb95fda56133","markDefs":[],"children":[{"marks":[],"text":"","_key":"f6e0e895f80c0","_type":"span"}]},{"style":"normal","_key":"0ccfcb5e774f","markDefs":[],"children":[{"_type":"span","marks":[],"text":"There were 5890 samples from the CLSA used to assess the association between VCDR and IOP and PRS. The researchers found that the baseline model accounted for 3.8% (95% CI, 2.9-4.8) of the variance in unadjusted VCDR and 2.5% (95% CI, 1.8-3.4) in adjusted VCDR. The new PRS was able to explain 22.0% (95% CI, 20.1-23.9) of the variance in phenotypes within the adjusted VCDR and 21.9% (95% CI, 20.1-23.8) in the unadjusted VCDR, both in the CLSA dataset. Variance in phenotypes for IOP was also able to be explained at a rate of 12.9% (95% CI, 11.3-14.6). A total of 3.1% (95% CI, 2.3-4.0) of the variance in phenotypes was accounted for in the baseline model.","_key":"f5f452e25bfb0"}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"33c845647c800"}],"_type":"block","style":"normal","_key":"a5736b4dd160"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"There were 1588 samples in the BHAS dataset that were used to perform a PRS validation. The variance was explained in 0.98% (95% CI, 0.3-2.2) of the adjusted VCDR and 0.79% (95% CI, 0.2-1.9) of the unadjusted VCDR. The PRS was able to explain 19.7% of the variance and 18.3% of the variance in adjusted and unadjusted VCDR respectively. The IOP PRS was able to explain 9.6% of the variance in phenotype.","_key":"930813125b9a0"}],"_type":"block","style":"normal","_key":"02c8c8603bf2"},{"_type":"block","style":"normal","_key":"caaba898e18a","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"0c9b75272a210"}]},{"_type":"block","style":"normal","_key":"dda6d5f007f3","markDefs":[],"children":[{"_key":"46d4c2f6522f0","_type":"span","marks":[],"text":"Using the UK Biobank, the VCDR PRS variance explained in 5.2%, 12.1%, and 14.3% for African, East Asian, and South Asian populations, respectively; IOP PRS variance explained 2.3%, 3.2%, and 7.5% in those same populations."}]},{"children":[{"marks":[],"text":"","_key":"04a78f2b647b0","_type":"span"}],"_type":"block","style":"normal","_key":"213a552c37af","markDefs":[]},{"style":"normal","_key":"50dc4c8a5683","markDefs":[],"children":[{"marks":[],"text":"There were some limitations to this study. The PRS was drawn from samples of individuals with European ancestry and was less predictive in people without European ancestry because of this. Future studies for African individuals may be needed in this field to account for differences in IOP in this subgroup. These results have also not affected clinically relevant outcomes for glaucoma.","_key":"e0deafb898610","_type":"span"}],"_type":"block"},{"children":[{"text":"","_key":"4e0e4b3f8a4c0","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"c64585f13b1b","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"The researchers concluded that a new PRS based on the latest genome-wide association studies, which was able to predict VCDR or IOP more accurately compared with previous data. This can be used to help predict glaucoma in these patients.","_key":"0c3b3eb89de70"}],"_type":"block","style":"normal","_key":"728778586a7f"},{"_type":"block","style":"normal","_key":"50122bb8dee3","markDefs":[],"children":[{"text":"","_key":"f180f3f2b3d80","_type":"span","marks":[]}]},{"_type":"block","style":"normal","_key":"883895790dd6","markDefs":[],"children":[{"_key":"26be2a5de4dd0","_type":"span","marks":[],"text":""}]},{"_key":"000d4a45ae22","markDefs":[],"children":[{"marks":[],"text":"","_key":"ff85dadfd2450","_type":"span"}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"b2f9764b35a6","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"References","_key":"8ca96352537b0"}]},{"level":1,"_type":"block","style":"normal","_key":"4f42f7b3c3dc","listItem":"number","markDefs":[],"children":[{"_type":"span","marks":[],"text":"He W, Lee SSY, Diaz Torres S, et al. 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