CINXE.COM

<!doctype html> <html xmlns="http://www.w3.org/1999/xhtml" lang="en" xml:lang="en" itemscope itemtype="http://schema.org/Article" class="no-js"> <head prefix="og: http://ogp.me/ns#"> <base href="https://journals.plos.org/plosone/s/editorial-and-publishing-policies"> <link rel="stylesheet" href="/resource/css/site-content.css?79f248ebefa43b7800a14562e5049ab4">  <link rel="stylesheet" type="text/css" href="https://fonts.googleapis.com/css?family=Open+Sans:400,400i,600"> <link media="print" rel="stylesheet" type="text/css" href="/resource/css/print.css"> <script type="text/javascript"> var siteUrlPrefix = "/plosone/"; </script> <script src="/resource/js/vendor/modernizr-v2.7.1.js" type="text/javascript"></script> <script src="/resource/js/vendor/detectizr.min.js" type="text/javascript"></script> <link rel="shortcut icon" href="/resource/img/favicon.ico" type="image/x-icon"> <meta http-equiv="Content-Type" content="text/html; charset=utf-8"> <script type="text/javascript"> var googletag = googletag || {}; googletag.cmd = googletag.cmd || []; (function() { var gads = document.createElement('script'); gads.async = true; gads.type = 'text/javascript'; var useSSL = 'https:' == document.location.protocol; gads.src = (useSSL ? 'https:' : 'http:') + '//www.googletagservices.com/tag/js/gpt.js'; var node = document.getElementsByTagName('script')[0]; node.parentNode.insertBefore(gads, node); })(); </script> <script id="doubleClickSetupScript" type="text/javascript"> googletag.cmd.push(function() { googletag.defineSlot('/75507958/PONE_728x90_ATF', [728, 90], 'div-gpt-ad-1458247671871-0').addService(googletag.pubads()); googletag.defineSlot('/75507958/PONE_160x600_BTF', [160, 600], 'div-gpt-ad-1458247671871-1').addService(googletag.pubads()); var personalizedAds = window.plosCookieConsent && window.plosCookieConsent.hasConsented('advertising'); googletag.pubads().setRequestNonPersonalizedAds(personalizedAds ? 0 : 1); googletag.pubads().enableSingleRequest(); googletag.enableServices(); }); </script> <script type="text/javascript"> var WombatConfig = WombatConfig || {}; WombatConfig.journalKey = "PLoSONE"; WombatConfig.journalName = "PLOS ONE"; WombatConfig.figurePath = "/plosone/article/figure/image"; WombatConfig.figShareInstitutionString = "plos"; WombatConfig.doiResolverPrefix = "https://dx.plos.org/"; </script> <script type="text/javascript"> var WombatConfig = WombatConfig || {}; WombatConfig.metrics = WombatConfig.metrics || {}; WombatConfig.metrics.referenceUrl = "http://lagotto.io/plos"; WombatConfig.metrics.googleScholarUrl = "https://scholar.google.com/scholar"; WombatConfig.metrics.googleScholarCitationUrl = WombatConfig.metrics.googleScholarUrl + "?hl=en&lr=&q="; WombatConfig.metrics.crossrefUrl = "https://www.crossref.org"; </script> <script defer src="/resource/js/defer.js?13928eb59791c3cc61cf"></script> <script src="/resource/js/sync.js?13928eb59791c3cc61cf"></script> <script src="/resource/js/vendor/jquery.min.js" type="text/javascript"></script> <script src="/resource/js/vendor/fastclick/lib/fastclick.js" type="text/javascript"></script> <script src="/resource/js/vendor/foundation/foundation.js" type="text/javascript"></script> <script src="/resource/js/vendor/underscore-min.js" type="text/javascript"></script> <script src="/resource/js/vendor/underscore.string.min.js" type="text/javascript"></script> <script src="/resource/js/vendor/moment.js" type="text/javascript"></script> <script src="/resource/js/vendor/jquery-ui-effects.min.js" type="text/javascript"></script> <script src="/resource/js/vendor/foundation/foundation.tooltip.js" type="text/javascript"></script> <script src="/resource/js/vendor/foundation/foundation.dropdown.js" type="text/javascript"></script> <script src="/resource/js/vendor/foundation/foundation.tab.js" type="text/javascript"></script> <script src="/resource/js/vendor/foundation/foundation.reveal.js" type="text/javascript"></script> <script src="/resource/js/vendor/foundation/foundation.slider.js" type="text/javascript"></script> <script src="/resource/js/util/utils.js" type="text/javascript"></script> <script src="/resource/js/components/toggle.js" type="text/javascript"></script> <script src="/resource/js/components/truncate_elem.js" type="text/javascript"></script> <script src="/resource/js/components/tooltip_hover.js" type="text/javascript"></script> <script src="/resource/js/vendor/jquery.dotdotdot.js" type="text/javascript"></script> <script> dataLayer = [{ 'mobileSite': 'false', 'desktopSite': 'true' }]; </script> <title>PLOS ONE</title> <script> $(document).ready(()=> { let lemurTitle = $('article > h1').text(); if (lemurTitle && lemurTitle != '') { $('title').text(lemurTitle + ' | ' + 'PLOS ONE'); } }); </script> <meta http-equiv="X-Translated-By" content="Google"> <meta http-equiv="X-Translated-To" content="ru"> <script type="text/javascript" src="https://www.gstatic.com/_/translate_http/_/js/k=translate_http.tr.en_GB.1hbgkFx4Qn8.O/am=DgY/d=1/rs=AN8SPfqlmAPxwfG457BPbRXwNq39oSMGHg/m=corsproxy" data-sourceurl="https://journals.plos.org/plosone/s/editorial-and-publishing-policies"></script> <link href="https://fonts.googleapis.com/css2?family=Material+Symbols+Outlined:opsz,wght,FILL,GRAD@20..48,100..700,0..1,-50..200" rel="stylesheet"> <script type="text/javascript" src="https://www.gstatic.com/_/translate_http/_/js/k=translate_http.tr.en_GB.1hbgkFx4Qn8.O/am=DgY/d=1/exm=corsproxy/ed=1/rs=AN8SPfqlmAPxwfG457BPbRXwNq39oSMGHg/m=phishing_protection" data-phishing-protection-enabled="false" data-forms-warning-enabled="true" data-source-url="https://journals.plos.org/plosone/s/editorial-and-publishing-policies"></script> <meta name="robots" content="none"> </head> <body class="static plosone"> <script type="text/javascript" src="https://www.gstatic.com/_/translate_http/_/js/k=translate_http.tr.en_GB.1hbgkFx4Qn8.O/am=DgY/d=1/exm=corsproxy,phishing_protection/ed=1/rs=AN8SPfqlmAPxwfG457BPbRXwNq39oSMGHg/m=navigationui" data-environment="prod" data-proxy-url="https://journals-plos-org.translate.goog" data-proxy-full-url="https://journals-plos-org.translate.goog/plosone/s/editorial-and-publishing-policies?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB" data-source-url="https://journals.plos.org/plosone/s/editorial-and-publishing-policies" data-source-language="pl" data-target-language="ru" data-display-language="en-GB" data-detected-source-language="" data-is-source-untranslated="false" data-source-untranslated-url="https://translate.google.com/website?sl=pl&tl=ru&hl=en-GB&u=https://journals.plos.org/plosone/s/editorial-and-publishing-policies&anno=2" data-client="tr"></script> <noscript> <iframe src="//www.googletagmanager.com/ns.html?id=GTM-TP26BH" height="0" width="0" style="display:none;visibility:hidden"></iframe> </noscript> <script> (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= '//www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer','GTM-TP26BH'); </script> <noscript> <iframe src="//www.googletagmanager.com/ns.html?id=GTM-MQQMGF" height="0" width="0" style="display:none;visibility:hidden"></iframe> </noscript> <script>(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= '//www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer','GTM-MQQMGF');</script>  <script type="text/javascript"> ;window.NREUM||(NREUM={});NREUM.init={distributed_tracing:{enabled:true},privacy:{cookies_enabled:true},ajax:{deny_list:["bam.nr-data.net"]}}; window.NREUM||(NREUM={}),__nr_require=function(t,e,n){function r(n){if(!e[n]){var o=e[n]={exports:{}};t[n][0].call(o.exports,function(e){var o=t[n][1][e];return r(o||e)},o,o.exports)}return e[n].exports}if("function"==typeof __nr_require)return __nr_require;for(var o=0;o<n.length;o++)r(n[o]);return r}({1:[function(t,e,n){function r(t){try{s.console&&console.log(t)}catch(e){}}var o,i=t("ee"),a=t(32),s={};try{o=localStorage.getItem("__nr_flags").split(","),console&&"function"==typeof console.log&&(s.console=!0,o.indexOf("dev")!==-1&&(s.dev=!0),o.indexOf("nr_dev")!==-1&&(s.nrDev=!0))}catch(c){}s.nrDev&&i.on("internal-error",function(t){r(t.stack)}),s.dev&&i.on("fn-err",function(t,e,n){r(n.stack)}),s.dev&&(r("NR AGENT IN DEVELOPMENT MODE"),r("flags: "+a(s,function(t,e){return t}).join(", ")))},{}],2:[function(t,e,n){function r(t,e,n,r,s){try{l?l-=1:o(s||new UncaughtException(t,e,n),!0)}catch(f){try{i("ierr",[f,c.now(),!0])}catch(d){}}return"function"==typeof u&&u.apply(this,a(arguments))}function UncaughtException(t,e,n){this.message=t||"Uncaught error with no additional information",this.sourceURL=e,this.line=n}function o(t,e){var n=e?null:c.now();i("err",[t,n])}var i=t("handle"),a=t(33),s=t("ee"),c=t("loader"),f=t("gos"),u=window.onerror,d=!1,p="nr@seenError";if(!c.disabled){var l=0;c.features.err=!0,t(1),window.onerror=r;try{throw new Error}catch(h){"stack"in h&&(t(14),t(13),"addEventListener"in window&&t(7),c.xhrWrappable&&t(15),d=!0)}s.on("fn-start",function(t,e,n){d&&(l+=1)}),s.on("fn-err",function(t,e,n){d&&!n[p]&&(f(n,p,function(){return!0}),this.thrown=!0,o(n))}),s.on("fn-end",function(){d&&!this.thrown&&l>0&&(l-=1)}),s.on("internal-error",function(t){i("ierr",[t,c.now(),!0])})}},{}],3:[function(t,e,n){var r=t("loader");r.disabled||(r.features.ins=!0)},{}],4:[function(t,e,n){function r(){U++,L=g.hash,this[u]=y.now()}function o(){U--,g.hash!==L&&i(0,!0);var t=y.now();this[h]=~~this[h]+t-this[u],this[d]=t}function i(t,e){E.emit("newURL",[""+g,e])}function a(t,e){t.on(e,function(){this[e]=y.now()})}var s="-start",c="-end",f="-body",u="fn"+s,d="fn"+c,p="cb"+s,l="cb"+c,h="jsTime",m="fetch",v="addEventListener",w=window,g=w.location,y=t("loader");if(w[v]&&y.xhrWrappable&&!y.disabled){var x=t(11),b=t(12),E=t(9),R=t(7),O=t(14),T=t(8),P=t(15),S=t(10),M=t("ee"),N=M.get("tracer"),C=t(23);t(17),y.features.spa=!0;var L,U=0;M.on(u,r),b.on(p,r),S.on(p,r),M.on(d,o),b.on(l,o),S.on(l,o),M.buffer([u,d,"xhr-resolved"]),R.buffer([u]),O.buffer(["setTimeout"+c,"clearTimeout"+s,u]),P.buffer([u,"new-xhr","send-xhr"+s]),T.buffer([m+s,m+"-done",m+f+s,m+f+c]),E.buffer(["newURL"]),x.buffer([u]),b.buffer(["propagate",p,l,"executor-err","resolve"+s]),N.buffer([u,"no-"+u]),S.buffer(["new-jsonp","cb-start","jsonp-error","jsonp-end"]),a(T,m+s),a(T,m+"-done"),a(S,"new-jsonp"),a(S,"jsonp-end"),a(S,"cb-start"),E.on("pushState-end",i),E.on("replaceState-end",i),w[v]("hashchange",i,C(!0)),w[v]("load",i,C(!0)),w[v]("popstate",function(){i(0,U>1)},C(!0))}},{}],5:[function(t,e,n){function r(){var t=new PerformanceObserver(function(t,e){var n=t.getEntries();s(v,[n])});try{t.observe({entryTypes:["resource"]})}catch(e){}}function o(t){if(s(v,[window.performance.getEntriesByType(w)]),window.performance["c"+p])try{window.performance[h](m,o,!1)}catch(t){}else try{window.performance[h]("webkit"+m,o,!1)}catch(t){}}function i(t){}if(window.performance&&window.performance.timing&&window.performance.getEntriesByType){var a=t("ee"),s=t("handle"),c=t(14),f=t(13),u=t(6),d=t(23),p="learResourceTimings",l="addEventListener",h="removeEventListener",m="resourcetimingbufferfull",v="bstResource",w="resource",g="-start",y="-end",x="fn"+g,b="fn"+y,E="bstTimer",R="pushState",O=t("loader");if(!O.disabled){O.features.stn=!0,t(9),"addEventListener"in window&&t(7);var T=NREUM.o.EV;a.on(x,function(t,e){var n=t[0];n instanceof T&&(this.bstStart=O.now())}),a.on(b,function(t,e){var n=t[0];n instanceof T&&s("bst",[n,e,this.bstStart,O.now()])}),c.on(x,function(t,e,n){this.bstStart=O.now(),this.bstType=n}),c.on(b,function(t,e){s(E,[e,this.bstStart,O.now(),this.bstType])}),f.on(x,function(){this.bstStart=O.now()}),f.on(b,function(t,e){s(E,[e,this.bstStart,O.now(),"requestAnimationFrame"])}),a.on(R+g,function(t){this.time=O.now(),this.startPath=location.pathname+location.hash}),a.on(R+y,function(t){s("bstHist",[location.pathname+location.hash,this.startPath,this.time])}),u()?(s(v,[window.performance.getEntriesByType("resource")]),r()):l in window.performance&&(window.performance["c"+p]?window.performance[l](m,o,d(!1)):window.performance[l]("webkit"+m,o,d(!1))),document[l]("scroll",i,d(!1)),document[l]("keypress",i,d(!1)),document[l]("click",i,d(!1))}}},{}],6:[function(t,e,n){e.exports=function(){return"PerformanceObserver"in window&&"function"==typeof window.PerformanceObserver}},{}],7:[function(t,e,n){function r(t){for(var e=t;e&&!e.hasOwnProperty(u);)e=Object.getPrototypeOf(e);e&&o(e)}function o(t){s.inPlace(t,[u,d],"-",i)}function i(t,e){return t[1]}var a=t("ee").get("events"),s=t("wrap-function")(a,!0),c=t("gos"),f=XMLHttpRequest,u="addEventListener",d="removeEventListener";e.exports=a,"getPrototypeOf"in Object?(r(document),r(window),r(f.prototype)):f.prototype.hasOwnProperty(u)&&(o(window),o(f.prototype)),a.on(u+"-start",function(t,e){var n=t[1];if(null!==n&&("function"==typeof n||"object"==typeof n)){var r=c(n,"nr@wrapped",function(){function t(){if("function"==typeof n.handleEvent)return n.handleEvent.apply(n,arguments)}var e={object:t,"function":n}[typeof n];return e?s(e,"fn-",null,e.name||"anonymous"):n});this.wrapped=t[1]=r}}),a.on(d+"-start",function(t){t[1]=this.wrapped||t[1]})},{}],8:[function(t,e,n){function r(t,e,n){var r=t[e];"function"==typeof r&&(t[e]=function(){var t=i(arguments),e={};o.emit(n+"before-start",[t],e);var a;e[m]&&e[m].dt&&(a=e[m].dt);var s=r.apply(this,t);return o.emit(n+"start",[t,a],s),s.then(function(t){return o.emit(n+"end",[null,t],s),t},function(t){throw o.emit(n+"end",[t],s),t})})}var o=t("ee").get("fetch"),i=t(33),a=t(32);e.exports=o;var s=window,c="fetch-",f=c+"body-",u=["arrayBuffer","blob","json","text","formData"],d=s.Request,p=s.Response,l=s.fetch,h="prototype",m="nr@context";d&&p&&l&&(a(u,function(t,e){r(d[h],e,f),r(p[h],e,f)}),r(s,"fetch",c),o.on(c+"end",function(t,e){var n=this;if(e){var r=e.headers.get("content-length");null!==r&&(n.rxSize=r),o.emit(c+"done",[null,e],n)}else o.emit(c+"done",[t],n)}))},{}],9:[function(t,e,n){var r=t("ee").get("history"),o=t("wrap-function")(r);e.exports=r;var i=window.history&&window.history.constructor&&window.history.constructor.prototype,a=window.history;i&&i.pushState&&i.replaceState&&(a=i),o.inPlace(a,["pushState","replaceState"],"-")},{}],10:[function(t,e,n){function r(t){function e(){f.emit("jsonp-end",[],l),t.removeEventListener("load",e,c(!1)),t.removeEventListener("error",n,c(!1))}function n(){f.emit("jsonp-error",[],l),f.emit("jsonp-end",[],l),t.removeEventListener("load",e,c(!1)),t.removeEventListener("error",n,c(!1))}var r=t&&"string"==typeof t.nodeName&&"script"===t.nodeName.toLowerCase();if(r){var o="function"==typeof t.addEventListener;if(o){var a=i(t.src);if(a){var d=s(a),p="function"==typeof d.parent[d.key];if(p){var l={};u.inPlace(d.parent,[d.key],"cb-",l),t.addEventListener("load",e,c(!1)),t.addEventListener("error",n,c(!1)),f.emit("new-jsonp",[t.src],l)}}}}}function o(){return"addEventListener"in window}function i(t){var e=t.match(d);return e?e[1]:null}function a(t,e){var n=t.match(l),r=n[1],o=n[3];return o?a(o,e[r]):e[r]}function s(t){var e=t.match(p);return e&&e.length>=3?{key:e[2],parent:a(e[1],window)}:{key:t,parent:window}}var c=t(23),f=t("ee").get("jsonp"),u=t("wrap-function")(f);if(e.exports=f,o()){var d=/[?&](?:callback|cb)=([^&#]+)/,p=/(.*)\.([^.]+)/,l=/^(\w+)(\.|$)(.*)$/,h=["appendChild","insertBefore","replaceChild"];Node&&Node.prototype&&Node.prototype.appendChild?u.inPlace(Node.prototype,h,"dom-"):(u.inPlace(HTMLElement.prototype,h,"dom-"),u.inPlace(HTMLHeadElement.prototype,h,"dom-"),u.inPlace(HTMLBodyElement.prototype,h,"dom-")),f.on("dom-start",function(t){r(t[0])})}},{}],11:[function(t,e,n){var r=t("ee").get("mutation"),o=t("wrap-function")(r),i=NREUM.o.MO;e.exports=r,i&&(window.MutationObserver=function(t){return this instanceof i?new i(o(t,"fn-")):i.apply(this,arguments)},MutationObserver.prototype=i.prototype)},{}],12:[function(t,e,n){function r(t){var e=i.context(),n=s(t,"executor-",e,null,!1),r=new f(n);return i.context(r).getCtx=function(){return e},r}var o=t("wrap-function"),i=t("ee").get("promise"),a=t("ee").getOrSetContext,s=o(i),c=t(32),f=NREUM.o.PR;e.exports=i,f&&(window.Promise=r,["all","race"].forEach(function(t){var e=f[t];f[t]=function(n){function r(t){return function(){i.emit("propagate",[null,!o],a,!1,!1),o=o||!t}}var o=!1;c(n,function(e,n){Promise.resolve(n).then(r("all"===t),r(!1))});var a=e.apply(f,arguments),s=f.resolve(a);return s}}),["resolve","reject"].forEach(function(t){var e=f[t];f[t]=function(t){var n=e.apply(f,arguments);return t!==n&&i.emit("propagate",[t,!0],n,!1,!1),n}}),f.prototype["catch"]=function(t){return this.then(null,t)},f.prototype=Object.create(f.prototype,{constructor:{value:r}}),c(Object.getOwnPropertyNames(f),function(t,e){try{r[e]=f[e]}catch(n){}}),o.wrapInPlace(f.prototype,"then",function(t){return function(){var e=this,n=o.argsToArray.apply(this,arguments),r=a(e);r.promise=e,n[0]=s(n[0],"cb-",r,null,!1),n[1]=s(n[1],"cb-",r,null,!1);var c=t.apply(this,n);return r.nextPromise=c,i.emit("propagate",[e,!0],c,!1,!1),c}}),i.on("executor-start",function(t){t[0]=s(t[0],"resolve-",this,null,!1),t[1]=s(t[1],"resolve-",this,null,!1)}),i.on("executor-err",function(t,e,n){t[1](n)}),i.on("cb-end",function(t,e,n){i.emit("propagate",[n,!0],this.nextPromise,!1,!1)}),i.on("propagate",function(t,e,n){this.getCtx&&!e||(this.getCtx=function(){if(t instanceof Promise)var e=i.context(t);return e&&e.getCtx?e.getCtx():this})}),r.toString=function(){return""+f})},{}],13:[function(t,e,n){var r=t("ee").get("raf"),o=t("wrap-function")(r),i="equestAnimationFrame";e.exports=r,o.inPlace(window,["r"+i,"mozR"+i,"webkitR"+i,"msR"+i],"raf-"),r.on("raf-start",function(t){t[0]=o(t[0],"fn-")})},{}],14:[function(t,e,n){function r(t,e,n){t[0]=a(t[0],"fn-",null,n)}function o(t,e,n){this.method=n,this.timerDuration=isNaN(t[1])?0:+t[1],t[0]=a(t[0],"fn-",this,n)}var i=t("ee").get("timer"),a=t("wrap-function")(i),s="setTimeout",c="setInterval",f="clearTimeout",u="-start",d="-";e.exports=i,a.inPlace(window,[s,"setImmediate"],s+d),a.inPlace(window,[c],c+d),a.inPlace(window,[f,"clearImmediate"],f+d),i.on(c+u,r),i.on(s+u,o)},{}],15:[function(t,e,n){function r(t,e){d.inPlace(e,["onreadystatechange"],"fn-",s)}function o(){var t=this,e=u.context(t);t.readyState>3&&!e.resolved&&(e.resolved=!0,u.emit("xhr-resolved",[],t)),d.inPlace(t,y,"fn-",s)}function i(t){x.push(t),m&&(E?E.then(a):w?w(a):(R=-R,O.data=R))}function a(){for(var t=0;t<x.length;t++)r([],x[t]);x.length&&(x=[])}function s(t,e){return e}function c(t,e){for(var n in t)e[n]=t[n];return e}t(7);var f=t("ee"),u=f.get("xhr"),d=t("wrap-function")(u),p=t(23),l=NREUM.o,h=l.XHR,m=l.MO,v=l.PR,w=l.SI,g="readystatechange",y=["onload","onerror","onabort","onloadstart","onloadend","onprogress","ontimeout"],x=[];e.exports=u;var b=window.XMLHttpRequest=function(t){var e=new h(t);try{u.emit("new-xhr",[e],e),e.addEventListener(g,o,p(!1))}catch(n){try{u.emit("internal-error",[n])}catch(r){}}return e};if(c(h,b),b.prototype=h.prototype,d.inPlace(b.prototype,["open","send"],"-xhr-",s),u.on("send-xhr-start",function(t,e){r(t,e),i(e)}),u.on("open-xhr-start",r),m){var E=v&&v.resolve();if(!w&&!v){var R=1,O=document.createTextNode(R);new m(a).observe(O,{characterData:!0})}}else f.on("fn-end",function(t){t[0]&&t[0].type===g||a()})},{}],16:[function(t,e,n){function r(t){if(!s(t))return null;var e=window.NREUM;if(!e.loader_config)return null;var n=(e.loader_config.accountID||"").toString()||null,r=(e.loader_config.agentID||"").toString()||null,f=(e.loader_config.trustKey||"").toString()||null;if(!n||!r)return null;var h=l.generateSpanId(),m=l.generateTraceId(),v=Date.now(),w={spanId:h,traceId:m,timestamp:v};return(t.sameOrigin||c(t)&&p())&&(w.traceContextParentHeader=o(h,m),w.traceContextStateHeader=i(h,v,n,r,f)),(t.sameOrigin&&!u()||!t.sameOrigin&&c(t)&&d())&&(w.newrelicHeader=a(h,m,v,n,r,f)),w}function o(t,e){return"00-"+e+"-"+t+"-01"}function i(t,e,n,r,o){var i=0,a="",s=1,c="",f="";return o+"@nr="+i+"-"+s+"-"+n+"-"+r+"-"+t+"-"+a+"-"+c+"-"+f+"-"+e}function a(t,e,n,r,o,i){var a="btoa"in window&&"function"==typeof window.btoa;if(!a)return null;var s={v:[0,1],d:{ty:"Browser",ac:r,ap:o,id:t,tr:e,ti:n}};return i&&r!==i&&(s.d.tk=i),btoa(JSON.stringify(s))}function s(t){return f()&&c(t)}function c(t){var e=!1,n={};if("init"in NREUM&&"distributed_tracing"in NREUM.init&&(n=NREUM.init.distributed_tracing),t.sameOrigin)e=!0;else if(n.allowed_origins instanceof Array)for(var r=0;r<n.allowed_origins.length;r++){var o=h(n.allowed_origins[r]);if(t.hostname===o.hostname&&t.protocol===o.protocol&&t.port===o.port){e=!0;break}}return e}function f(){return"init"in NREUM&&"distributed_tracing"in NREUM.init&&!!NREUM.init.distributed_tracing.enabled}function u(){return"init"in NREUM&&"distributed_tracing"in NREUM.init&&!!NREUM.init.distributed_tracing.exclude_newrelic_header}function d(){return"init"in NREUM&&"distributed_tracing"in NREUM.init&&NREUM.init.distributed_tracing.cors_use_newrelic_header!==!1}function p(){return"init"in NREUM&&"distributed_tracing"in NREUM.init&&!!NREUM.init.distributed_tracing.cors_use_tracecontext_headers}var l=t(29),h=t(18);e.exports={generateTracePayload:r,shouldGenerateTrace:s}},{}],17:[function(t,e,n){function r(t){var e=this.params,n=this.metrics;if(!this.ended){this.ended=!0;for(var r=0;r<p;r++)t.removeEventListener(d[r],this.listener,!1);e.aborted||(n.duration=a.now()-this.startTime,this.loadCaptureCalled||4!==t.readyState?null==e.status&&(e.status=0):i(this,t),n.cbTime=this.cbTime,s("xhr",[e,n,this.startTime,this.endTime,"xhr"],this))}}function o(t,e){var n=c(e),r=t.params;r.hostname=n.hostname,r.port=n.port,r.protocol=n.protocol,r.host=n.hostname+":"+n.port,r.pathname=n.pathname,t.parsedOrigin=n,t.sameOrigin=n.sameOrigin}function i(t,e){t.params.status=e.status;var n=v(e,t.lastSize);if(n&&(t.metrics.rxSize=n),t.sameOrigin){var r=e.getResponseHeader("X-NewRelic-App-Data");r&&(t.params.cat=r.split(", ").pop())}t.loadCaptureCalled=!0}var a=t("loader");if(a.xhrWrappable&&!a.disabled){var s=t("handle"),c=t(18),f=t(16).generateTracePayload,u=t("ee"),d=["load","error","abort","timeout"],p=d.length,l=t("id"),h=t(24),m=t(22),v=t(19),w=t(23),g=NREUM.o.REQ,y=window.XMLHttpRequest;a.features.xhr=!0,t(15),t(8),u.on("new-xhr",function(t){var e=this;e.totalCbs=0,e.called=0,e.cbTime=0,e.end=r,e.ended=!1,e.xhrGuids={},e.lastSize=null,e.loadCaptureCalled=!1,e.params=this.params||{},e.metrics=this.metrics||{},t.addEventListener("load",function(n){i(e,t)},w(!1)),h&&(h>34||h<10)||t.addEventListener("progress",function(t){e.lastSize=t.loaded},w(!1))}),u.on("open-xhr-start",function(t){this.params={method:t[0]},o(this,t[1]),this.metrics={}}),u.on("open-xhr-end",function(t,e){"loader_config"in NREUM&&"xpid"in NREUM.loader_config&&this.sameOrigin&&e.setRequestHeader("X-NewRelic-ID",NREUM.loader_config.xpid);var n=f(this.parsedOrigin);if(n){var r=!1;n.newrelicHeader&&(e.setRequestHeader("newrelic",n.newrelicHeader),r=!0),n.traceContextParentHeader&&(e.setRequestHeader("traceparent",n.traceContextParentHeader),n.traceContextStateHeader&&e.setRequestHeader("tracestate",n.traceContextStateHeader),r=!0),r&&(this.dt=n)}}),u.on("send-xhr-start",function(t,e){var n=this.metrics,r=t[0],o=this;if(n&&r){var i=m(r);i&&(n.txSize=i)}this.startTime=a.now(),this.listener=function(t){try{"abort"!==t.type||o.loadCaptureCalled||(o.params.aborted=!0),("load"!==t.type||o.called===o.totalCbs&&(o.onloadCalled||"function"!=typeof e.onload))&&o.end(e)}catch(n){try{u.emit("internal-error",[n])}catch(r){}}};for(var s=0;s<p;s++)e.addEventListener(d[s],this.listener,w(!1))}),u.on("xhr-cb-time",function(t,e,n){this.cbTime+=t,e?this.onloadCalled=!0:this.called+=1,this.called!==this.totalCbs||!this.onloadCalled&&"function"==typeof n.onload||this.end(n)}),u.on("xhr-load-added",function(t,e){var n=""+l(t)+!!e;this.xhrGuids&&!this.xhrGuids[n]&&(this.xhrGuids[n]=!0,this.totalCbs+=1)}),u.on("xhr-load-removed",function(t,e){var n=""+l(t)+!!e;this.xhrGuids&&this.xhrGuids[n]&&(delete this.xhrGuids[n],this.totalCbs-=1)}),u.on("xhr-resolved",function(){this.endTime=a.now()}),u.on("addEventListener-end",function(t,e){e instanceof y&&"load"===t[0]&&u.emit("xhr-load-added",[t[1],t[2]],e)}),u.on("removeEventListener-end",function(t,e){e instanceof y&&"load"===t[0]&&u.emit("xhr-load-removed",[t[1],t[2]],e)}),u.on("fn-start",function(t,e,n){e instanceof y&&("onload"===n&&(this.onload=!0),("load"===(t[0]&&t[0].type)||this.onload)&&(this.xhrCbStart=a.now()))}),u.on("fn-end",function(t,e){this.xhrCbStart&&u.emit("xhr-cb-time",[a.now()-this.xhrCbStart,this.onload,e],e)}),u.on("fetch-before-start",function(t){function e(t,e){var n=!1;return e.newrelicHeader&&(t.set("newrelic",e.newrelicHeader),n=!0),e.traceContextParentHeader&&(t.set("traceparent",e.traceContextParentHeader),e.traceContextStateHeader&&t.set("tracestate",e.traceContextStateHeader),n=!0),n}var n,r=t[1]||{};"string"==typeof t[0]?n=t[0]:t[0]&&t[0].url?n=t[0].url:window.URL&&t[0]&&t[0]instanceof URL&&(n=t[0].href),n&&(this.parsedOrigin=c(n),this.sameOrigin=this.parsedOrigin.sameOrigin);var o=f(this.parsedOrigin);if(o&&(o.newrelicHeader||o.traceContextParentHeader))if("string"==typeof t[0]||window.URL&&t[0]&&t[0]instanceof URL){var i={};for(var a in r)i[a]=r[a];i.headers=new Headers(r.headers||{}),e(i.headers,o)&&(this.dt=o),t.length>1?t[1]=i:t.push(i)}else t[0]&&t[0].headers&&e(t[0].headers,o)&&(this.dt=o)}),u.on("fetch-start",function(t,e){this.params={},this.metrics={},this.startTime=a.now(),this.dt=e,t.length>=1&&(this.target=t[0]),t.length>=2&&(this.opts=t[1]);var n,r=this.opts||{},i=this.target;"string"==typeof i?n=i:"object"==typeof i&&i instanceof g?n=i.url:window.URL&&"object"==typeof i&&i instanceof URL&&(n=i.href),o(this,n);var s=(""+(i&&i instanceof g&&i.method||r.method||"GET")).toUpperCase();this.params.method=s,this.txSize=m(r.body)||0}),u.on("fetch-done",function(t,e){this.endTime=a.now(),this.params||(this.params={}),this.params.status=e?e.status:0;var n;"string"==typeof this.rxSize&&this.rxSize.length>0&&(n=+this.rxSize);var r={txSize:this.txSize,rxSize:n,duration:a.now()-this.startTime};s("xhr",[this.params,r,this.startTime,this.endTime,"fetch"],this)})}},{}],18:[function(t,e,n){var r={};e.exports=function(t){if(t in r)return r[t];var e=document.createElement("a"),n=window.location,o={};e.href=t,o.port=e.port;var i=e.href.split("://");!o.port&&i[1]&&(o.port=i[1].split("/")[0].split("@").pop().split(":")[1]),o.port&&"0"!==o.port||(o.port="https"===i[0]?"443":"80"),o.hostname=e.hostname||n.hostname,o.pathname=e.pathname,o.protocol=i[0],"/"!==o.pathname.charAt(0)&&(o.pathname="/"+o.pathname);var a=!e.protocol||":"===e.protocol||e.protocol===n.protocol,s=e.hostname===document.domain&&e.port===n.port;return o.sameOrigin=a&&(!e.hostname||s),"/"===o.pathname&&(r[t]=o),o}},{}],19:[function(t,e,n){function r(t,e){var n=t.responseType;return"json"===n&&null!==e?e:"arraybuffer"===n||"blob"===n||"json"===n?o(t.response):"text"===n||""===n||void 0===n?o(t.responseText):void 0}var o=t(22);e.exports=r},{}],20:[function(t,e,n){function r(){}function o(t,e,n,r){return function(){return u.recordSupportability("API/"+e+"/called"),i(t+e,[f.now()].concat(s(arguments)),n?null:this,r),n?void 0:this}}var i=t("handle"),a=t(32),s=t(33),c=t("ee").get("tracer"),f=t("loader"),u=t(25),d=NREUM;"undefined"==typeof window.newrelic&&(newrelic=d);var p=["setPageViewName","setCustomAttribute","setErrorHandler","finished","addToTrace","inlineHit","addRelease"],l="api-",h=l+"ixn-";a(p,function(t,e){d[e]=o(l,e,!0,"api")}),d.addPageAction=o(l,"addPageAction",!0),d.setCurrentRouteName=o(l,"routeName",!0),e.exports=newrelic,d.interaction=function(){return(new r).get()};var m=r.prototype={createTracer:function(t,e){var n={},r=this,o="function"==typeof e;return i(h+"tracer",[f.now(),t,n],r),function(){if(c.emit((o?"":"no-")+"fn-start",[f.now(),r,o],n),o)try{return e.apply(this,arguments)}catch(t){throw c.emit("fn-err",[arguments,this,t],n),t}finally{c.emit("fn-end",[f.now()],n)}}}};a("actionText,setName,setAttribute,save,ignore,onEnd,getContext,end,get".split(","),function(t,e){m[e]=o(h,e)}),newrelic.noticeError=function(t,e){"string"==typeof t&&(t=new Error(t)),u.recordSupportability("API/noticeError/called"),i("err",[t,f.now(),!1,e])}},{}],21:[function(t,e,n){function r(t){if(NREUM.init){for(var e=NREUM.init,n=t.split("."),r=0;r<n.length-1;r++)if(e=e[n[r]],"object"!=typeof e)return;return e=e[n[n.length-1]]}}e.exports={getConfiguration:r}},{}],22:[function(t,e,n){e.exports=function(t){if("string"==typeof t&&t.length)return t.length;if("object"==typeof t){if("undefined"!=typeof ArrayBuffer&&t instanceof ArrayBuffer&&t.byteLength)return t.byteLength;if("undefined"!=typeof Blob&&t instanceof Blob&&t.size)return t.size;if(!("undefined"!=typeof FormData&&t instanceof FormData))try{return JSON.stringify(t).length}catch(e){return}}}},{}],23:[function(t,e,n){var r=!1;try{var o=Object.defineProperty({},"passive",{get:function(){r=!0}});window.addEventListener("testPassive",null,o),window.removeEventListener("testPassive",null,o)}catch(i){}e.exports=function(t){return r?{passive:!0,capture:!!t}:!!t}},{}],24:[function(t,e,n){var r=0,o=navigator.userAgent.match(/Firefox[\/\s](\d+\.\d+)/);o&&(r=+o[1]),e.exports=r},{}],25:[function(t,e,n){function r(t,e){var n=[a,t,{name:t},e];return i("storeMetric",n,null,"api"),n}function o(t,e){var n=[s,t,{name:t},e];return i("storeEventMetrics",n,null,"api"),n}var i=t("handle"),a="sm",s="cm";e.exports={constants:{SUPPORTABILITY_METRIC:a,CUSTOM_METRIC:s},recordSupportability:r,recordCustom:o}},{}],26:[function(t,e,n){function r(){return s.exists&&performance.now?Math.round(performance.now()):(i=Math.max((new Date).getTime(),i))-a}function o(){return i}var i=(new Date).getTime(),a=i,s=t(34);e.exports=r,e.exports.offset=a,e.exports.getLastTimestamp=o},{}],27:[function(t,e,n){function r(t){return!(!t||!t.protocol||"file:"===t.protocol)}e.exports=r},{}],28:[function(t,e,n){function r(t,e){var n=t.getEntries();n.forEach(function(t){"first-paint"===t.name?p("timing",["fp",Math.floor(t.startTime)]):"first-contentful-paint"===t.name&&p("timing",["fcp",Math.floor(t.startTime)])})}function o(t,e){var n=t.getEntries();if(n.length>0){var r=n[n.length-1];if(c&&c<r.startTime)return;p("lcp",[r])}}function i(t){t.getEntries().forEach(function(t){t.hadRecentInput||p("cls",[t])})}function a(t){if(t instanceof v&&!g){var e=Math.round(t.timeStamp),n={type:t.type};e<=l.now()?n.fid=l.now()-e:e>l.offset&&e<=Date.now()?(e-=l.offset,n.fid=l.now()-e):e=l.now(),g=!0,p("timing",["fi",e,n])}}function s(t){"hidden"===t&&(c=l.now(),p("pageHide",[c]))}if(!("init"in NREUM&&"page_view_timing"in NREUM.init&&"enabled"in NREUM.init.page_view_timing&&NREUM.init.page_view_timing.enabled===!1)){var c,f,u,d,p=t("handle"),l=t("loader"),h=t(31),m=t(23),v=NREUM.o.EV;if("PerformanceObserver"in window&&"function"==typeof window.PerformanceObserver){f=new PerformanceObserver(r);try{f.observe({entryTypes:["paint"]})}catch(w){}u=new PerformanceObserver(o);try{u.observe({entryTypes:["largest-contentful-paint"]})}catch(w){}d=new PerformanceObserver(i);try{d.observe({type:"layout-shift",buffered:!0})}catch(w){}}if("addEventListener"in document){var g=!1,y=["click","keydown","mousedown","pointerdown","touchstart"];y.forEach(function(t){document.addEventListener(t,a,m(!1))})}h(s)}},{}],29:[function(t,e,n){function r(){function t(){return e?15&e[n++]:16*Math.random()|0}var e=null,n=0,r=window.crypto||window.msCrypto;r&&r.getRandomValues&&(e=r.getRandomValues(new Uint8Array(31)));for(var o,i="xxxxxxxx-xxxx-4xxx-yxxx-xxxxxxxxxxxx",a="",s=0;s<i.length;s++)o=i[s],"x"===o?a+=t().toString(16):"y"===o?(o=3&t()|8,a+=o.toString(16)):a+=o;return a}function o(){return a(16)}function i(){return a(32)}function a(t){function e(){return n?15&n[r++]:16*Math.random()|0}var n=null,r=0,o=window.crypto||window.msCrypto;o&&o.getRandomValues&&Uint8Array&&(n=o.getRandomValues(new Uint8Array(31)));for(var i=[],a=0;a<t;a++)i.push(e().toString(16));return i.join("")}e.exports={generateUuid:r,generateSpanId:o,generateTraceId:i}},{}],30:[function(t,e,n){function r(t,e){if(!o)return!1;if(t!==o)return!1;if(!e)return!0;if(!i)return!1;for(var n=i.split("."),r=e.split("."),a=0;a<r.length;a++)if(r[a]!==n[a])return!1;return!0}var o=null,i=null,a=/Version\/(\S+)\s+Safari/;if(navigator.userAgent){var s=navigator.userAgent,c=s.match(a);c&&s.indexOf("Chrome")===-1&&s.indexOf("Chromium")===-1&&(o="Safari",i=c[1])}e.exports={agent:o,version:i,match:r}},{}],31:[function(t,e,n){function r(t){function e(){t(s&&document[s]?document[s]:document[i]?"hidden":"visible")}"addEventListener"in document&&a&&document.addEventListener(a,e,o(!1))}var o=t(23);e.exports=r;var i,a,s;"undefined"!=typeof document.hidden?(i="hidden",a="visibilitychange",s="visibilityState"):"undefined"!=typeof document.msHidden?(i="msHidden",a="msvisibilitychange"):"undefined"!=typeof document.webkitHidden&&(i="webkitHidden",a="webkitvisibilitychange",s="webkitVisibilityState")},{}],32:[function(t,e,n){function r(t,e){var n=[],r="",i=0;for(r in t)o.call(t,r)&&(n[i]=e(r,t[r]),i+=1);return n}var o=Object.prototype.hasOwnProperty;e.exports=r},{}],33:[function(t,e,n){function r(t,e,n){e||(e=0),"undefined"==typeof n&&(n=t?t.length:0);for(var r=-1,o=n-e||0,i=Array(o<0?0:o);++r<o;)i[r]=t[e+r];return i}e.exports=r},{}],34:[function(t,e,n){e.exports={exists:"undefined"!=typeof window.performance&&window.performance.timing&&"undefined"!=typeof window.performance.timing.navigationStart}},{}],ee:[function(t,e,n){function r(){}function o(t){function e(t){return t&&t instanceof r?t:t?f(t,c,a):a()}function n(n,r,o,i,a){if(a!==!1&&(a=!0),!l.aborted||i){t&&a&&t(n,r,o);for(var s=e(o),c=m(n),f=c.length,u=0;u<f;u++)c[u].apply(s,r);var p=d[y[n]];return p&&p.push([x,n,r,s]),s}}function i(t,e){g[t]=m(t).concat(e)}function h(t,e){var n=g[t];if(n)for(var r=0;r<n.length;r++)n[r]===e&&n.splice(r,1)}function m(t){return g[t]||[]}function v(t){return p[t]=p[t]||o(n)}function w(t,e){l.aborted||u(t,function(t,n){e=e||"feature",y[n]=e,e in d||(d[e]=[])})}var g={},y={},x={on:i,addEventListener:i,removeEventListener:h,emit:n,get:v,listeners:m,context:e,buffer:w,abort:s,aborted:!1};return x}function i(t){return f(t,c,a)}function a(){return new r}function s(){(d.api||d.feature)&&(l.aborted=!0,d=l.backlog={})}var c="nr@context",f=t("gos"),u=t(32),d={},p={},l=e.exports=o();e.exports.getOrSetContext=i,l.backlog=d},{}],gos:[function(t,e,n){function r(t,e,n){if(o.call(t,e))return t[e];var r=n();if(Object.defineProperty&&Object.keys)try{return Object.defineProperty(t,e,{value:r,writable:!0,enumerable:!1}),r}catch(i){}return t[e]=r,r}var o=Object.prototype.hasOwnProperty;e.exports=r},{}],handle:[function(t,e,n){function r(t,e,n,r){o.buffer([t],r),o.emit(t,e,n)}var o=t("ee").get("handle");e.exports=r,r.ee=o},{}],id:[function(t,e,n){function r(t){var e=typeof t;return!t||"object"!==e&&"function"!==e?-1:t===window?0:a(t,i,function(){return o++})}var o=1,i="nr@id",a=t("gos");e.exports=r},{}],loader:[function(t,e,n){function r(){if(!P++){var t=T.info=NREUM.info,e=v.getElementsByTagName("script")[0];if(setTimeout(f.abort,3e4),!(t&&t.licenseKey&&t.applicationID&&e))return f.abort();c(R,function(e,n){t[e]||(t[e]=n)});var n=a();s("mark",["onload",n+T.offset],null,"api"),s("timing",["load",n]);var r=v.createElement("script");0===t.agent.indexOf("http://")||0===t.agent.indexOf("https://")?r.src=t.agent:r.src=h+"://"+t.agent,e.parentNode.insertBefore(r,e)}}function o(){"complete"===v.readyState&&i()}function i(){s("mark",["domContent",a()+T.offset],null,"api")}var a=t(26),s=t("handle"),c=t(32),f=t("ee"),u=t(30),d=t(27),p=t(21),l=t(23),h=p.getConfiguration("ssl")===!1?"http":"https",m=window,v=m.document,w="addEventListener",g="attachEvent",y=m.XMLHttpRequest,x=y&&y.prototype,b=!d(m.location);NREUM.o={ST:setTimeout,SI:m.setImmediate,CT:clearTimeout,XHR:y,REQ:m.Request,EV:m.Event,PR:m.Promise,MO:m.MutationObserver};var E=""+location,R={beacon:"bam.nr-data.net",errorBeacon:"bam.nr-data.net",agent:"js-agent.newrelic.com/nr-spa-1212.min.js"},O=y&&x&&x[w]&&!/CriOS/.test(navigator.userAgent),T=e.exports={offset:a.getLastTimestamp(),now:a,origin:E,features:{},xhrWrappable:O,userAgent:u,disabled:b};if(!b){t(20),t(28),v[w]?(v[w]("DOMContentLoaded",i,l(!1)),m[w]("load",r,l(!1))):(v[g]("onreadystatechange",o),m[g]("onload",r)),s("mark",["firstbyte",a.getLastTimestamp()],null,"api");var P=0}},{}],"wrap-function":[function(t,e,n){function r(t,e){function n(e,n,r,c,f){function nrWrapper(){var i,a,u,p;try{a=this,i=d(arguments),u="function"==typeof r?r(i,a):r||{}}catch(l){o([l,"",[i,a,c],u],t)}s(n+"start",[i,a,c],u,f);try{return p=e.apply(a,i)}catch(h){throw s(n+"err",[i,a,h],u,f),h}finally{s(n+"end",[i,a,p],u,f)}}return a(e)?e:(n||(n=""),nrWrapper[p]=e,i(e,nrWrapper,t),nrWrapper)}function r(t,e,r,o,i){r||(r="");var s,c,f,u="-"===r.charAt(0);for(f=0;f<e.length;f++)c=e[f],s=t[c],a(s)||(t[c]=n(s,u?c+r:r,o,c,i))}function s(n,r,i,a){if(!h||e){var s=h;h=!0;try{t.emit(n,r,i,e,a)}catch(c){o([c,n,r,i],t)}h=s}}return t||(t=u),n.inPlace=r,n.flag=p,n}function o(t,e){e||(e=u);try{e.emit("internal-error",t)}catch(n){}}function i(t,e,n){if(Object.defineProperty&&Object.keys)try{var r=Object.keys(t);return r.forEach(function(n){Object.defineProperty(e,n,{get:function(){return t[n]},set:function(e){return t[n]=e,e}})}),e}catch(i){o([i],n)}for(var a in t)l.call(t,a)&&(e[a]=t[a]);return e}function a(t){return!(t&&t instanceof Function&&t.apply&&!t[p])}function s(t,e){var n=e(t);return n[p]=t,i(t,n,u),n}function c(t,e,n){var r=t[e];t[e]=s(r,n)}function f(){for(var t=arguments.length,e=new Array(t),n=0;n<t;++n)e[n]=arguments[n];return e}var u=t("ee"),d=t(33),p="nr@original",l=Object.prototype.hasOwnProperty,h=!1;e.exports=r,e.exports.wrapFunction=s,e.exports.wrapInPlace=c,e.exports.argsToArray=f},{}]},{},["loader",2,17,5,3,4]); ;NREUM.loader_config={accountID:"804283",trustKey:"804283",agentID:"402703674",licenseKey:"cf99e8d2a3",applicationID:"402703674"} ;NREUM.info={beacon:"bam.nr-data.net",errorBeacon:"bam.nr-data.net",licenseKey:"cf99e8d2a3", // Modified this value from the generated script, to pass prod vs dev applicationID: window.location.hostname.includes('journals.plos.org') ? "402703674" : "402694889", sa:1} </script> <header> <div id="topslot" class="head-top"><a id="skip-to-content" tabindex="0" class="button" href="https://journals-plos-org.translate.goog/plosone/s/editorial-and-publishing-policies?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB#main-content"> Skip to main content </a> <div class="center"> <div class="title"> Advertisement </div> <div class="advertisement" id="div-gpt-ad-1458247671871-0" style="width:728px; height:90px;"> <script type="text/javascript"> googletag.cmd.push(function() { googletag.display('div-gpt-ad-1458247671871-0'); }); </script> </div> </div> </div> <div id="user" class="nav" data-user-management-url="https://community.plos.org"> </div> <div id="pagehdr"> <nav class="nav-main"> <h1 class="logo"><a href="https://journals-plos-org.translate.goog/plosone/?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">PLOS ONE</a></h1> <section class="top-bar-section"> <ul class="nav-elements"> <li class="multi-col-parent menu-section-header has-dropdown" id="publish">Publish <div class="dropdown mega "> <ul class="multi-col" id="publish-dropdown-list"> <li class="menu-section-header " id="submissions"><span class="menu-section-header-title"> Submissions </span> <ul class="menu-section " id="submissions-dropdown-list"> <li><a href="https://journals-plos-org.translate.goog/plosone/s/getting-started?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Getting Started</a></li> <li><a href="https://journals-plos-org.translate.goog/plosone/s/submission-guidelines?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Submission Guidelines</a></li> <li><a href="https://journals-plos-org.translate.goog/plosone/s/figures?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Figures</a></li> <li><a href="https://journals-plos-org.translate.goog/plosone/s/tables?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Tables</a></li> <li><a href="https://journals-plos-org.translate.goog/plosone/s/supporting-information?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Supporting Information</a></li> <li><a href="https://journals-plos-org.translate.goog/plosone/s/latex?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">LaTeX</a></li> <li><a href="https://journals-plos-org.translate.goog/plosone/s/what-we-publish?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">What We Publish</a></li> <li><a href="https://journals-plos-org.translate.goog/plosone/s/preprints?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Preprints</a></li> <li><a href="https://journals-plos-org.translate.goog/plosone/s/revising-your-manuscript?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Revising Your Manuscript</a></li> <li><a href="https://journals-plos-org.translate.goog/plosone/s/submit-now?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Submit Now</a></li> <li><a href="https://translate.google.com/website?sl=pl&tl=ru&hl=en-GB&u=https://collections.plos.org/s/calls-for-papers">Calls for Papers</a></li> </ul></li> <li class="menu-section-header " id="policies"><span class="menu-section-header-title"> Policies </span> <ul class="menu-section " id="policies-dropdown-list"> <li><a href="https://journals-plos-org.translate.goog/plosone/s/best-practices-in-research-reporting?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Best Practices in Research Reporting</a></li> <li><a href="https://journals-plos-org.translate.goog/plosone/s/human-subjects-research?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Human Subjects Research</a></li> <li><a href="https://journals-plos-org.translate.goog/plosone/s/animal-research?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Animal Research</a></li> <li><a href="https://journals-plos-org.translate.goog/plosone/s/competing-interests?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Competing Interests</a></li> <li><a href="https://journals-plos-org.translate.goog/plosone/s/disclosure-of-funding-sources?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Disclosure of Funding Sources</a></li> <li><a href="https://journals-plos-org.translate.goog/plosone/s/licenses-and-copyright?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Licenses and Copyright</a></li> <li><a href="https://journals-plos-org.translate.goog/plosone/s/data-availability?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Data Availability</a></li> <li><a href="https://journals-plos-org.translate.goog/plosone/s/complementary-research?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Complementary Research</a></li> <li><a href="https://journals-plos-org.translate.goog/plosone/s/materials-software-and-code-sharing?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Materials, Software and Code Sharing</a></li> <li><a href="https://journals-plos-org.translate.goog/plosone/s/ethical-publishing-practice?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Ethical Publishing Practice</a></li> <li><a href="https://journals-plos-org.translate.goog/plosone/s/authorship?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Authorship</a></li> <li><a href="https://journals-plos-org.translate.goog/plosone/s/corrections-expressions-of-concern-and-retractions?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Corrections, Expressions of Concern, and Retractions</a></li> </ul></li> <li class="menu-section-header " id="manuscript-review-and-publication"><span class="menu-section-header-title"> Manuscript Review and Publication </span> <ul class="menu-section " id="manuscript-review-and-publication-dropdown-list"> <li><a href="https://journals-plos-org.translate.goog/plosone/s/criteria-for-publication?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Criteria for Publication</a></li> <li><a href="https://journals-plos-org.translate.goog/plosone/s/editorial-and-peer-review-process?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Editorial and Peer Review Process</a></li> <li><a href="https://translate.google.com/website?sl=pl&tl=ru&hl=en-GB&u=https://plos.org/resources/editor-center">Editor Center</a></li> <li><a href="https://journals-plos-org.translate.goog/plosone/s/resources-for-editors?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Resources for Editors</a></li> <li><a href="https://journals-plos-org.translate.goog/plosone/s/reviewer-guidelines?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Guidelines for Reviewers</a></li> <li><a href="https://journals-plos-org.translate.goog/plosone/s/accepted-manuscripts?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Accepted Manuscripts</a></li> <li><a href="https://journals-plos-org.translate.goog/plosone/s/comments?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Comments</a></li> </ul></li> </ul> <div class="calloutcontainer"> <h3 class="callout-headline">Submit Your Manuscript</h3> <div class="action-contain"> <p class="callout-content">Discover a faster, simpler path to publishing in a high-quality journal. <em>PLOS ONE</em> promises fair, rigorous peer review, broad scope, and wide readership – a perfect fit for your research every time.</p> <p class="button-contain special"><a class="button button-default" href="https://journals-plos-org.translate.goog/plosone/static/publish?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB"> Learn More </a> <a class="button-link" href="https://translate.google.com/website?sl=pl&tl=ru&hl=en-GB&u=https://www.editorialmanager.com/pone/default.asp"> Submit Now </a></p> </div> </div> </div></li> <li class="menu-section-header has-dropdown " id="about"><span class="menu-section-header-title"> About </span> <ul class="menu-section dropdown " id="about-dropdown-list"> <li><a href="https://journals-plos-org.translate.goog/plosone/static/publish?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Why Publish with PLOS ONE</a></li> <li><a href="https://journals-plos-org.translate.goog/plosone/s/journal-information?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Journal Information</a></li> <li><a href="https://journals-plos-org.translate.goog/plosone/s/staff-editors?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Staff Editors</a></li> <li><a href="https://journals-plos-org.translate.goog/plosone/static/editorial-board?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Editorial Board</a></li> <li><a href="https://journals-plos-org.translate.goog/plosone/s/section-editors?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Section Editors</a></li> <li><a href="https://journals-plos-org.translate.goog/plosone/s/advisory-groups?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Advisory Groups</a></li> <li><a href="https://journals-plos-org.translate.goog/plosone/s/find-and-read-articles?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Find and Read Articles</a></li> <li><a href="https://journals-plos-org.translate.goog/plosone/s/publishing-information?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Publishing Information</a></li> <li><a href="https://translate.google.com/website?sl=pl&tl=ru&hl=en-GB&u=https://plos.org/publication-fees">Publication Fees</a></li> <li><a href="https://translate.google.com/website?sl=pl&tl=ru&hl=en-GB&u=https://plos.org/press-and-media">Press and Media</a></li> <li><a href="https://journals-plos-org.translate.goog/plosone/s/contact?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Contact</a></li> </ul></li> <li data-js-tooltip-hover="trigger" class="subject-area menu-section-header">Browse</li> <script src="/resource/js/vendor/jquery.hoverIntent.js" type="text/javascript"></script> <script src="/resource/js/components/menu_drop.js" type="text/javascript"></script> <script src="/resource/js/components/hover_delay.js" type="text/javascript"></script> <li id="navsearch" class="head-search"> <form name="searchForm" action="/plosone/search" method="get"> <fieldset><legend>Search</legend> <label for="search">Search</label> <div class="search-contain"><input id="search" type="text" name="q" placeholder="SEARCH" required> <button id="headerSearchButton" type="submit" aria-label="Submit search"> <i title="Submit search" class="search-icon"></i> </button> </div> </fieldset><input type="hidden" name="filterJournals" value="PLoSONE"> </form><a id="advSearch" href="https://journals-plos-org.translate.goog/plosone/search?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB"> advanced search </a> <script src="/resource/js/components/placeholder_style.js" type="text/javascript"></script></li> </ul> </section> </nav> </div> </header> <section id="taxonomyContainer"> <script src="/resource/js/taxonomy-browser.js" type="text/javascript"></script> <div id="taxonomy-browser" class="areas" data-search-url="/plosone/browse"> <div class="wrapper"> <div class="taxonomy-header"> Browse Subject Areas <div id="subjInfo"> ? </div> <div id="subjInfoText"> <p>Click through the PLOS taxonomy to find articles in your field.</p> <p>For more information about PLOS Subject Areas, click <a href="https://translate.google.com/website?sl=pl&tl=ru&hl=en-GB&u=https://github.com/PLOS/plos-thesaurus/blob/master/README.md" target="_blank" title="Link opens in new window">here</a>.</p> </div> </div> <div class="levels"> <div class="levels-container cf"> <div class="levels-position"></div> </div><a href="https://journals-plos-org.translate.goog/plosone/s/editorial-and-publishing-policies?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB#" class="prev"></a> <a href="https://journals-plos-org.translate.goog/plosone/s/editorial-and-publishing-policies?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB#" class="next active"></a> </div> </div> <div class="taxonomy-browser-border-bottom"></div> </div> </section> <main id="main-content"> <div class="lemur-content full-width"> <article> <h1>Editorial and Publishing Policies</h1> <div data-section-id="445"> <div class="block-global-alert"> The following editorial and publishing policies apply to all of PLOS journals, unless otherwise noted.  </div> <table class="table-basic"> <tbody> <tr> <td><h4><a href="https://journals-plos-org.translate.goog/plosone/s/best-practices-in-research-reporting?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Best Practices in Research Reporting</a></h4></td> </tr> <tr> <td><h4><a href="https://journals-plos-org.translate.goog/plosone/s/animal-research?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Animal Research</a></h4></td> </tr> <tr> <td><h4><a href="https://journals-plos-org.translate.goog/plosone/s/human-subjects-research?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Human Subjects Research</a></h4></td> </tr> <tr> <td><h4><a href="https://journals-plos-org.translate.goog/plosone/s/competing-interests?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Competing Interests</a></h4></td> </tr> <tr> <td><h4><a href="https://journals-plos-org.translate.goog/plosone/s/disclosure-of-funding-sources?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Disclosure of Funding Sources</a></h4></td> </tr> <tr> <td><h4><a href="https://journals-plos-org.translate.goog/plosone/s/licenses-and-copyright?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Licenses and Copyright</a></h4></td> </tr> <tr> <td><h4><a href="https://journals-plos-org.translate.goog/plosone/s/data-availability?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Data Availability</a></h4></td> </tr> <tr> <td><h4><a href="https://journals-plos-org.translate.goog/plosone/s/materials-software-and-code-sharing?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Materials, Software and Code Sharing</a></h4></td> </tr> <tr> <td><h4><a href="https://journals-plos-org.translate.goog/plosone/s/ethical-publishing-practice?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Ethical Publishing Practice</a></h4></td> </tr> <tr> <td><h4><a data-parent-id="undefined" href="https://journals-plos-org.translate.goog/plosone/s/authorship?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Authorship</a></h4></td> </tr> <tr> <td><h4> </h4></td> </tr> </tbody> </table> </div> </article> </div> <script defer src="/resource/js/components/scroll.js" type="text/javascript"></script> <script defer src="/resource/js/components/floating_nav.js" type="text/javascript"></script> <script defer src="/resource/js/pages/site_content.js" type="text/javascript"></script> </main> <footer id="pageftr"> <div class="row"> <div class="block x-small"> <ul class="nav nav-secondary"> <li class="ftr-header"><a href="https://translate.google.com/website?sl=pl&tl=ru&hl=en-GB&u=https://plos.org/publications/journals/">Publications</a></li> <li><a href="https://journals-plos-org.translate.goog/plosbiology/?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB" id="ftr-bio">PLOS Biology</a></li> <li><a href="https://journals-plos-org.translate.goog/climate/?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB" id="ftr-climate">PLOS Climate</a></li> <li><a href="https://journals-plos-org.translate.goog/complexsystems/?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB" id="ftr-complex-systems">PLOS Complex Systems</a></li> <li><a href="https://journals-plos-org.translate.goog/ploscompbiol/?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB" id="ftr-compbio">PLOS Computational Biology</a></li> <li><a href="https://journals-plos-org.translate.goog/digitalhealth/?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB" id="ftr-digitalhealth">PLOS Digital Health</a></li> <li><a href="https://journals-plos-org.translate.goog/plosgenetics/?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB" id="ftr-gen">PLOS Genetics</a></li> <li><a href="https://journals-plos-org.translate.goog/globalpublichealth/?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB" id="ftr-globalpublichealth">PLOS Global Public Health</a></li> </ul> </div> <div class="block x-small"> <ul class="nav nav-secondary"> <li class="ftr-header"> </li> <li><a href="https://journals-plos-org.translate.goog/plosmedicine/?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB" id="ftr-med">PLOS Medicine</a></li> <li><a href="https://journals-plos-org.translate.goog/mentalhealth/?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB" id="ftr-mental-health">PLOS Mental Health</a></li> <li><a href="https://journals-plos-org.translate.goog/plosntds/?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB" id="ftr-ntds">PLOS Neglected Tropical Diseases</a></li> <li><a href="https://journals-plos-org.translate.goog/plosone/?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB" id="ftr-one">PLOS ONE</a></li> <li><a href="https://journals-plos-org.translate.goog/plospathogens/?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB" id="ftr-path">PLOS Pathogens</a></li> <li><a href="https://journals-plos-org.translate.goog/sustainabilitytransformation/?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB" id="ftr-sustainabilitytransformation">PLOS Sustainability and Transformation</a></li> <li><a href="https://journals-plos-org.translate.goog/water/?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB" id="ftr-water">PLOS Water</a></li> </ul> </div> <div class="block xx-small"> <ul class="nav nav-tertiary"> <li><a href="https://translate.google.com/website?sl=pl&tl=ru&hl=en-GB&u=https://plos.org" id="ftr-home">Home</a></li> <li><a href="https://translate.google.com/website?sl=pl&tl=ru&hl=en-GB&u=https://blogs.plos.org" id="ftr-blog">Blogs</a></li> <li><a href="https://translate.google.com/website?sl=pl&tl=ru&hl=en-GB&u=https://collections.plos.org/" id="ftr-collections">Collections</a></li> <li><a href="mailto:webmaster@plos.org?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB" id="ftr-feedback">Give feedback</a></li> <li><a href="https://journals-plos-org.translate.goog/plosone/lockss-manifest?_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB" id="ftr-lockss">LOCKSS</a></li> </ul> </div> <div class="block xx-small"> <ul class="nav nav-primary"> <li><a href="https://translate.google.com/website?sl=pl&tl=ru&hl=en-GB&u=https://plos.org/privacy-policy" id="ftr-privacy">Privacy Policy</a></li> <li><a href="https://translate.google.com/website?sl=pl&tl=ru&hl=en-GB&u=https://plos.org/terms-of-use" id="ftr-terms">Terms of Use</a></li> <li><a href="https://translate.google.com/website?sl=pl&tl=ru&hl=en-GB&u=https://plos.org/advertise/" id="ftr-advertise">Advertise</a></li> <li><a href="https://translate.google.com/website?sl=pl&tl=ru&hl=en-GB&u=https://plos.org/media-inquiries" id="ftr-media">Media Inquiries</a></li> <li><a href="https://translate.google.com/website?sl=pl&tl=ru&hl=en-GB&u=https://plos.org/contact" id="ftr-contact">Contact</a></li> </ul> </div> </div> <div class="row"> <p><img src="/resource/img/logo-plos-footer.png" alt="PLOS" class="logo-footer"> <span class="footer-non-profit-statement">PLOS is a nonprofit 501(c)(3) corporation, #C2354500, based in San Francisco, California, US</span></p> <div class="block"> </div> </div> <script src="/resource/js/global.js" type="text/javascript"></script> </footer> <script>function gtElInit() {var lib = new google.translate.TranslateService();lib.translatePage('pl', 'ru', function () {});}</script> <script src="https://translate.google.com/translate_a/element.js?cb=gtElInit&hl=en-GB&client=wt" type="text/javascript"></script> </body> </html>