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Journal of Neuroscience

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id="front-page-container"> <div class="panel-row-wrapper clearfix"> <div class="top-left-wrapper grid-17 suffix-1 alpha"> <div class="panel-panel panel-region-top-left panel-region-content"> <div class="inside"><div class="panel-pane pane-custom pane-1 jneuro-cover-info-below" > <div class="pane-content"> <p><a href="/content/current">Current Issue Table of Contents: 27 Nov 2024 Volume 44, Issue 48</a></p> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-panels-mini pane-sfneneuro-about-cover jneuro-cover-info" > <div class="pane-content"> <div class="panel-display panel-2col clearfix" id="mini-panel-sfneneuro_about_cover"> <div class="panel-panel panel-col-first"> <div class="inside"><div class="panel-pane pane-highwire-issue-cover" > <div class="pane-content"> <div class = "cover-issue"><div class = "cover-issue-image"><a href="/content/44/48.toc" class="" data-icon-position="" data-hide-link-title="0"><img src="https://www.jneurosci.org/sites/default/files/styles/large/public/highwire/jneuro/44/48.cover-source.jpg?itok=CjIRIFvd" alt="The Journal of Neuroscience: 44 (48)" /></a></div></div> </div> </div> </div> </div> <div class="panel-panel panel-col-last"> <div class="inside"><div class="panel-pane pane-highwire-markup" > <h2 class="pane-title">About the Cover</h2> <div class="pane-content"> <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" id="content-block" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div><span class="highwire-journal-article-marker-start"></span><div class="caption cover-img"><p id="p-1">Shown is a cortical neuron with CD2AP tagged with green fluorescent protein to show its expression. Fluorescence was color-coded from blue (at its brightest) to yellow (dimmer) to highlight where CD2AP is expressed in dendritic spines. Loss of function variants of the CD2AP gene may contribute to late-onset Alzheimer's disease. The technique used in this image helped uncover whether loss of CD2AP function contributes to synaptic dysfunction, which is one of the causal mechanisms for late-onset Alzheimer's disease. See <a href="https://doi.org/10.1523/JNEUROSCI.1734-23.2024">Farzaneh S. Mirfakhar et al.</a> for more information on how a variant of this gene contributes to synapse dysfunction. 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