CINXE.COM
KEGG DRUG: Mifepristone
<!doctype html> <html><head> <title>KEGG DRUG: Mifepristone</title> <link type="text/css" rel="stylesheet" href="/css/gn2.css?1746525059"> <link type="text/css" rel="stylesheet" href="/css/bget.css?1746525059"> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <link type="text/css" rel="stylesheet" href="/css/bgetm.css?1746525059" media="only screen and (max-width: 768px)"> <style>.kcfd{display:none;}</style> <script> <!-- var getElementsByClassName = document.getElementsByClassName ? function (cl){ return document.getElementsByClassName(cl); } : function (cl){ var elms = []; var objs = document.getElementsByTagName('*'); for(var i=0;i<objs.length;i++){ var obj = objs[i]; if(obj.className == cl){ elms.push(obj); } } return elms; }; function toggleField(clk,cl,show,hide){ var objs = getElementsByClassName(cl); for(var i=0;i<objs.length;i++){ var obj = objs[i]; if(!obj.style.display||obj.style.display == 'none'){ obj.style.display = 'block'; clk.innerHTML = ' « '+hide; } else{ obj.style.display = 'none'; clk.innerHTML = ' » '+show; } } } function toggleData(bobj,e){ var id = bobj.id.replace(/[^0-9]/g,''); var dt = document.getElementById('kcfd'+id); e.preventDefault(); if(!dt.style.display||dt.style.display == 'none'){ document.getElementById('kcfb'+id).innerHTML = 'Hide'; dt.style.display = 'block'; } else{ document.getElementById('kcfb'+id).innerHTML = 'Show'; dt.style.display = 'none'; } } function btn(bobj,img) { bobj.src = "/Fig/bget/button_" + img + ".gif"; } function btn_e(e) { e = e || event; var obj = e.target; var img = e.target.src; var img_base = img.replace(/\\/g,'/').replace(/(b|bd|bh)\.gif$/,''); if(e.type == 'mousedown'||e.type == 'touchstart'){ obj.src = img_base +'bd.gif'; } else if(e.type == 'mouseover'){ obj.src = img_base +'bh.gif'; } else if(e.type == 'mouseup'||e.type == 'touchend'){ obj.src = img_base +'b.gif'; } else if(e.type == 'mouseout'){ obj.src = img_base +'b.gif'; } } function init(){ for(var i=1;i<=1;i++){ if(document.getElementById('kcfb'+i)){ document.getElementById('kcfb'+i).onclick = function(e){toggleData(this,e);}; } } } function Link_XtrctSeq2(form) { var dna_from; var dna_to; var dna_len; var plus_up = Number(form.XtrctSeq_UP.value) ; var plus_down = Number(form.XtrctSeq_DOWN.value); var vector = Number(form.VECTOR.value); var org = form.ORG.value; var chr = form.CHR.value; var kid = form.KEGGID.value; var url; if (plus_up == 0 && plus_down == 0) { url = "/entry/-f+-n+n+" + kid; } else { if (vector == 1) { dna_from = Number(form.FROM.value) - plus_up; dna_to = Number(form.TO.value) + plus_down; } else { dna_from = Number(form.FROM.value) - plus_down; dna_to = Number(form.TO.value) + plus_up; } url = "/dbget-bin/cut_sequence_genes.pl?FROM=" + dna_from + "&TO=" + dna_to +"&VECTOR=" + vector + "&ORG=" + org; if (chr) url += "&CHR=" + chr; } //window.open( url, "_self" ); location.href = url; } function go_taxonomy(form,params){ for(var key in params){ if(form[key]){ form.setAttribute(key,params[key]); } else{ var obj = document.createElement('input'); obj.setAttribute('type','hidden'); obj.setAttribute('name',key); obj.setAttribute('value',params[key]); form.appendChild(obj); } } form.submit(); } window.onload=function(){window.focus();init();}; //---> </script> </head> <body> <div> <table border=0 cellpadding=0 cellspacing=0><tr><td> <table border=0 cellpadding=0 cellspacing=0 width="668"><tr><td width=70><a href="/kegg/drug"><img align="middle" alt="KEGG" border=0 src="/Fig/bget/kegg5.gif"></a></td><td> </td><td><a name="drug:D00585"></a><font class="title5">DRUG: Mifepristone</font></td><td class="tar vbot"><button class="btn" onclick="javascript:void(window.open('/kegg/document/help_bget_drug.html','KEGG_Help','toolbar=no,location=no,directories=no,width=720,height=640,resizable=yes,scrollbars=yes'));return false;">Help</button></td></tr></table><form method="post" action="/entry/" enctype="application/x-www-form-urlencoded" id="form1" name="form1"></form><table class="w1" width="650"> <tr> <td class="fr5 w1"> <table width="650" class="w2"> <tr><th class="th50 deft tal vmid"><span class="nowrap">Entry</span></th> <td class="td50 defd"><table class="w1" width="100%"><tr><td class="tal pd0"><code><span class="nowrap">D00585 Drug <br> </span></code></td></tr></table></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Name</span></th> <td class="td51 defd"><div class="cel">Mifepristone (JAN/USAN/INN);<br>Korlym (TN);<br>Mifeprex (TN)</div></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Product</span></th> <td class="td50 defd"><div class="cel"><a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=542f3fae-8bc8-4f00-9228-e4b66c9ad6a9">KORLYM (Corcept Therapeutics Incorporated)</a>, <a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=63c068cd-9370-460f-829b-70e8c7ebe91e">MIFEPRISTONE (Corcept Therapeutics Incorporated)</a></div></td></tr> <tr><th class="th51 rept tal vtop"><span class="nowrap"> Generic</span></th> <td class="td51 repd"><div class="cel"><a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=5e09acc0-fd26-4722-b8b3-46e560390d47">MIFEPRISTONE (Actavis Pharma)</a>, <a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=b63fad9b-7f12-4400-9019-b0586054e534">MIFEPRISTONE (GenBioPro)</a></div></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Formula</span></th> <td class="td50 defd"><div class="cel">C29H35NO2<br> </div></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Exact mass</span></th> <td class="td51 defd"><div class="cel">429.2668<br> </div></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Mol weight</span></th> <td class="td50 defd"><div class="cel">429.59<br> </div></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Structure</span></th> <td class="td51 defd"><a href="/Fig/drug/D00585.gif"><img name="img0" src="/Fig/drug/D00585.gif" style="max-width:600px" border=0></a><br> <button class="btn" onclick="location.href='/entry/-f+m+D00585';return false;">Mol file</button><button class="btn" onclick="location.href='/entry/-f+k+D00585';return false;">KCF file</button><button class="btn" onclick="location.href='https://www.genome.jp/tools-bin/strsearch_view?ENTRY=D00585&PROGRAM=simcomp&DATABASE=drug';return false;">DB search</button></td></tr> <tr><th class="th50 deft tal vmid"><span class="nowrap">Simcomp</span></th> <td class="td50 defd"><button class="btn" onclick="location.href='/kegg-bin/simcomp_list?id=D00585';return false;">Neighbor</button></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Class</span></th> <td class="td51 defd"><div class="cel"><span class="nowrap">Hormonal agent<br> <a href="/entry/DG01667">DG01667</a> Progesterone receptor antagonist<br> Metabolizing enzyme substrate<br> <a href="/entry/DG01633">DG01633</a> CYP3A/CYP3A4 substrate<br> <a href="/entry/DG02913">DG02913</a> CYP3A4 substrate<br> Metabolizing enzyme inhibitor<br> <a href="/entry/DG02852">DG02852</a> CYP3A/CYP3A4 inhibitor<br> </span></div></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Remark</span></th> <td class="td50 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">Same as: </span></td><td><a href="/entry/C07652">C07652</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">ATC code: </span></td><td><a href="/brite/br08303+D00585">G03XB01</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">Product: </span></td><td>D00585<US> </td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">Product (mixture): </span></td><td>D12586<<a href="/entry/dr_ja:D12586">JP</a>> </td></tr></table></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Efficacy</span></th> <td class="td51 defd"><div class="cel">Abortifacient, Contraceptive, Progesterone receptor antagonist</div></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Comment</span></th> <td class="td50 defd"><div class="cel">Treatment of gynecological disorders<br> </div></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Target</span></th> <td class="td51 defd"><div class="cel">NR3C3 (PGR) [HSA:<a href="/entry/hsa:5241">5241</a>] [KO:<a href="/entry/K08556">K08556</a>]<br>NR3C1 (GR) [HSA:<a href="/entry/hsa:2908">2908</a>] [KO:<a href="/entry/K05771">K05771</a>]</div></td></tr> <tr><th class="th50 rept tal vtop"><span class="nowrap"> Pathway</span></th> <td class="td50 repd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/hsa04080+2908">hsa04080</a> </span></td><td>Neuroactive ligand-receptor interaction</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/hsa04114+5241">hsa04114</a> </span></td><td>Oocyte meiosis</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/hsa04914+5241">hsa04914</a> </span></td><td>Progesterone-mediated oocyte maturation</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/hsa04915+5241">hsa04915</a> </span></td><td>Estrogen signaling pathway</td></tr></table></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Metabolism</span></th> <td class="td51 defd"><div class="cel">Enzyme: CYP3A4 [HSA:<a href="/entry/hsa:1576">1576</a>]<br> </div></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Interaction</span></th> <td class="td50 defd"><div class="cel">CYP inhibition: CYP3A [HSA:<a href="/entry/hsa:1576">1576</a> <a href="/entry/hsa:1577">1577</a> <a href="/entry/hsa:1551">1551</a>]<br> <button class="btn" onclick="location.href='/kegg-bin/ddi_list?drug=D00585';return false;">DDI search</button></div></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Structure map</span></th> <td class="td51 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/map07226+D00585">map07226</a> </span></td><td>Progesterone, androgen and estrogen receptor agonists/antagonists</td></tr></table></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Brite</span></th> <td class="td50 defd"><div class="cel"><span class="nowrap">Anatomical Therapeutic Chemical (ATC) classification [BR:<a href="/brite/br08303+D00585">br08303</a>]<br> G GENITO URINARY SYSTEM AND SEX HORMONES<br> G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM<br> G03X OTHER SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM<br> G03XB Progesterone receptor modulators<br> G03XB01 Mifepristone<br> D00585 Mifepristone (JAN/USAN/INN) <US><br> USP drug classification [BR:<a href="/brite/br08302+D00585">br08302</a>]<br> Hormonal Agents, Stimulant/Replacement/Modifying (Sex Hormones/Modifiers)<br> Hormonal Agents, Stimulant/Replacement/Modifying (Sex Hormones/Modifiers), Other<br> Mifepristone<br> D00585 Mifepristone (JAN/USAN/INN)<br> Drug groups [BR:<a href="/brite/br08330+D00585+DG01667">br08330</a>]<br> Hormonal agent<br> DG01667 Progesterone receptor antagonist<br> D00585 Mifepristone<br> Metabolizing enzyme substrate<br> DG01633 CYP3A/CYP3A4 substrate<br> DG02913 CYP3A4 substrate<br> D00585 Mifepristone<br> Metabolizing enzyme inhibitor<br> DG02852 CYP3A/CYP3A4 inhibitor<br> D00585 Mifepristone<br> Target-based classification of drugs [BR:<a href="/brite/br08310+D00585">br08310</a>]<br> Nuclear receptors<br> Estrogen like receptors<br> 3-Ketosteroid receptor<br> NR3C1 (GR)<br> D00585 Mifepristone (JAN/USAN/INN) <US><br> NR3C3 (PGR)<br> D00585 Mifepristone (JAN/USAN/INN) <US><br> New drug approvals in the USA [<a href="/kegg/drug/br08319.html?id=D00585">br08319.html</a>]<br> New molecular entities and new therapeutic biological products<br> D00585<br> New drug approvals in the USA, Europe and Japan [<a href="/kegg/drug/br08328.html?id=D00585">br08328.html</a>]<br> Approval dates by FDA, EMA and PMDA<br> D00585<br> Drug metabolizing enzymes and transporters [<a href="/kegg/drug/br08309.html?id=D00585">br08309.html</a>]<br> Drug metabolizing enzymes<br> D00585<br> </span></div><button class="btn" onclick="location.href='/kegg-bin/search_brite?option=-a&search_string=D00585';return false;">BRITE hierarchy</button></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Other DBs</span></th> <td class="td51 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">CAS: </span></td><td>84371-65-3</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">PubChem: </span></td><td><a href="https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=7847651">7847651</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">ChEBI: </span></td><td><a href="https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:50692">50692</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">PDB-CCD: </span></td><td><a href="https://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/486">486</a>[<a href="https://pdbj.org/mine/summary/486">PDBj</a>] </td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">LigandBox: </span></td><td><a href="http://www.mypresto5.com/ligandbox202210/cgi-bin/liginf.cgi?id=D00585&source=KEGG_DRUG">D00585</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">NIKKAJI: </span></td><td><a href="https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J23.743D">J23.743D</a></td></tr></table></td></tr> <tr><th class="th50 deft tal vmid"><span class="nowrap">LinkDB</span></th> <td class="td50 defd"><button class="btn" onclick="location.href='https://www.genome.jp/dbget-bin/get_linkdb?drug+D00585';return false;">All DBs</button></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">KCF data</span></th> <td class="td51 defd"><button class="btn" id="kcfb1">Show</button><div class="kcfd" id="kcfd1"><br>ATOM 32<br> 1 C2y C 24.5408 -18.3925<br> 2 C1y C 25.7249 -19.0925<br> 3 C1y C 24.5467 -17.0217<br> 4 C2y C 23.3450 -19.0808<br> 5 C1y C 26.9791 -18.4099<br> 6 C1x C 25.7249 -20.4632<br> 7 C1x C 25.7483 -16.3508<br> 8 C8y C 23.3683 -16.3275<br> 9 C2y C 23.3392 -20.4515<br> 10 C1x C 22.1551 -18.3867<br> 11 C1z C 26.9267 -17.0451<br> 12 C1x C 29.2774 -18.4392<br> 13 C1x C 24.5234 -21.1458<br> 14 C8x C 23.3859 -14.9625<br> 15 C8x C 22.1725 -17.0101<br> 16 C2x C 22.1551 -21.1399<br> 17 C1x C 20.9650 -19.0808<br> 18 C1z C 28.1225 -16.3799<br> 19 C1a C 26.9500 -15.7500<br> 20 C1x C 29.2950 -17.0742<br> 21 C8x C 22.1959 -14.2625<br> 22 C8x C 20.9884 -16.3158<br> 23 C5x C 20.9650 -20.4515<br> 24 C3b C 29.2483 -15.6801<br> 25 C8y C 21.0000 -14.9451<br> 26 O5x O 19.7751 -21.1399<br> 27 C3b C 30.4208 -14.9625<br> 28 N1c N 19.8159 -14.2392<br> 29 C1a C 31.5932 -14.2392<br> 30 C1a C 19.8276 -12.8684<br> 31 C1a C 18.6201 -14.9217<br> 32 O1a O 28.1225 -14.8399<br> BOND 36<br> 1 1 2 1<br> 2 1 3 1<br> 3 1 4 2<br> 4 2 5 1<br> 5 2 6 1<br> 6 3 7 1<br> 7 3 8 1 #Up<br> 8 4 9 1<br> 9 4 10 1<br> 10 5 11 1<br> 11 5 12 1<br> 12 6 13 1<br> 13 8 14 2<br> 14 8 15 1<br> 15 9 16 2<br> 16 10 17 1<br> 17 11 18 1<br> 18 11 19 1 #Up<br> 19 12 20 1<br> 20 14 21 1<br> 21 15 22 2<br> 22 16 23 1<br> 23 18 24 1 #Down<br> 24 21 25 2<br> 25 23 26 2<br> 26 24 27 3<br> 27 25 28 1<br> 28 27 29 1<br> 29 28 30 1<br> 30 28 31 1<br> 31 7 11 1<br> 32 9 13 1<br> 33 17 23 1<br> 34 18 20 1<br> 35 22 25 1<br> 36 18 32 1 #Up<br> </div></td></tr> </table></td></tr></table> <br><span style="font-size:12px"><a href="/entry/dr_ja:D00585">» Japanese version</a> <a href="javascript:history.back();">» Back</a></span><br><br></td></tr></table> <a href="/dbget/">DBGET</a> integrated database retrieval system</div> </body> </html>