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style="min-height:800px;aspect-ratio:unset;"><span aria-hidden="true" class="wp-block-cover__background has-background-dim-30 has-background-dim" style="background-color:#544e50"></span><img fetchpriority="high" decoding="async" width="1079" height="720" class="wp-block-cover__image-background wp-image-289" alt="" src="https://atuka.com/wp-content/uploads/2024/07/1715356691132.jpeg" style="object-position:21% 90%" data-object-fit="cover" data-object-position="21% 90%" srcset="https://atuka.com/wp-content/uploads/2024/07/1715356691132.jpeg 1079w, https://atuka.com/wp-content/uploads/2024/07/1715356691132-300x200.jpeg 300w, https://atuka.com/wp-content/uploads/2024/07/1715356691132-1024x683.jpeg 1024w, https://atuka.com/wp-content/uploads/2024/07/1715356691132-768x512.jpeg 768w" sizes="(max-width: 1079px) 100vw, 1079px" /><div class="wp-block-cover__inner-container is-layout-flow wp-block-cover-is-layout-flow"> <h2 class="wp-block-heading alignwide is-style-balanced-wrap has-alabaster-20-color has-text-color has-xx-large-font-size core-heading with-font-size core-heading-67b4cbef39c7f" style="padding-right:var(--wp--preset--spacing--40);padding-left:var(--wp--preset--spacing--40)">Advancing your therapeutic program</h2> <div class="wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-1 wp-block-columns-is-layout-flex"> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow" style="flex-basis:55%"> <div style="height:12px" aria-hidden="true" class="wp-block-spacer"></div> <p class="has-alabaster-20-color has-text-color has-medium-font-size core-paragraph with-font-size core-paragraph-67b4cbef3f8c9" style="padding-right:var(--wp--preset--spacing--40);padding-left:var(--wp--preset--spacing--40);line-height:1.3">With as much experience in Parkinson’s disease as anyone else in our space, an unsurpassed range of preclinical models, and expertise in gene therapy, Atuka is at the forefront of research that is helping to make new, life-changing therapeutics a reality.</p> </div> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow"></div> </div> </div></div> <div class="wp-block-columns is-layout-flex wp-container-core-columns-is-layout-2 wp-block-columns-is-layout-flex" style="padding-top:var(--wp--preset--spacing--30);padding-right:var(--wp--preset--spacing--60);padding-bottom:var(--wp--preset--spacing--30);padding-left:var(--wp--preset--spacing--60)"> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow"> <figure class="wp-block-image alignright size-large is-resized"><img decoding="async" width="1024" height="578" src="https://atuka.com/wp-content/uploads/2024/07/1717080993243-2-1024x578.jpeg" alt="" class="wp-image-281" style="width:583px;height:auto" srcset="https://atuka.com/wp-content/uploads/2024/07/1717080993243-2-1024x578.jpeg 1024w, https://atuka.com/wp-content/uploads/2024/07/1717080993243-2-300x169.jpeg 300w, https://atuka.com/wp-content/uploads/2024/07/1717080993243-2-768x433.jpeg 768w, https://atuka.com/wp-content/uploads/2024/07/1717080993243-2.jpeg 1276w" sizes="(max-width: 1024px) 100vw, 1024px" /></figure> </div> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow"> <p style="padding-right:var(--wp--preset--spacing--30);padding-left:var(--wp--preset--spacing--30)">We provide the best-tailored preclinical program to evaluate any potential therapeutic, whether for Parkinson’s, or the numerous other indications in which we have expertise, including cognitive disorders, ALS, and other movement disorders such as dystonia and dyskinesia—across multiple modalities, such as biologics (including gene therapy) and small molecules. </p> <p style="padding-right:var(--wp--preset--spacing--30);padding-left:var(--wp--preset--spacing--30)">Unlike other organizations that offer standardized approaches, each preclinical study is designed according to the unique mode of action and potential indication of a partner’s therapeutic to ensure the highest degree of translatability to Phase II clinical proof-of-concept—whether for overall efficacy or target engagement.</p> </div> </div> <div class="wp-block-columns is-layout-flex wp-container-core-columns-is-layout-3 wp-block-columns-is-layout-flex" style="padding-top:var(--wp--preset--spacing--10);padding-bottom:var(--wp--preset--spacing--10)"> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow" style="flex-basis:15%"></div> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow" style="flex-basis:60%"> <p class="has-jacarta-50-color has-text-color has-link-color has-x-large-font-size wp-elements-5445bbb1a7e1cf01da13ee689f53a290" style="padding-top:0;padding-right:var(--wp--preset--spacing--30);padding-bottom:0;padding-left:var(--wp--preset--spacing--30)">+ <a href="https://atuka.com/parkinsons-disease-models/" data-type="page" data-id="708">Our Parkinson’s disease models</a></p> <p class="has-jacarta-50-color has-text-color has-link-color has-x-large-font-size wp-elements-a8f4785b4127035a67950ca343c563aa" style="padding-top:0;padding-right:var(--wp--preset--spacing--30);padding-bottom:0;padding-left:var(--wp--preset--spacing--30)">+ <a href="https://atuka.com/gene-therapy/" data-type="page" data-id="1265">Gene therapy</a></p> </div> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow" style="flex-basis:25%"></div> </div> <div class="wp-block-columns is-layout-flex wp-container-core-columns-is-layout-4 wp-block-columns-is-layout-flex" style="padding-top:var(--wp--preset--spacing--40);padding-right:var(--wp--preset--spacing--60);padding-bottom:var(--wp--preset--spacing--40);padding-left:var(--wp--preset--spacing--60)"> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow"> <div style="height:12px" aria-hidden="true" class="wp-block-spacer"></div> <p class="has-jacarta-50-color has-text-color has-link-color has-small-font-size wp-elements-70562a5f10ed8014f4290a63d07584ae">SERVICES & CAPABILITIES</p> <div style="height:12px" aria-hidden="true" class="wp-block-spacer"></div> <p>In addition to our industry-leading suite of rodent and non-human primate (NHP) models, our extensive preclinical expertise in Parkinson’s and other disorders includes everything needed to keep your project under one roof—ensuring your therapeutic program gets the most out of its engagement with our highly respected team of neuroscientists. </p> <p>Atuka is also a world expert in NHP research and has the capacity to conduct both small and large studies that use up to 150 macaques at our newly renovated, AAALAC-accredited facility in Suzhou, China. As a result we are able to perform studies no other CRO can, while adhering to the highest standards of animal welfare.</p> <div style="height:6px" aria-hidden="true" class="wp-block-spacer"></div> <ul class="wp-block-list is-style-plus-list has-jacarta-50-color has-text-color has-link-color wp-elements-49e85cbfa99dfa45e4c5a59c7afdb3cb"> <li><strong>More about our services</strong></li> </ul> </div> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow"> <ul style="padding-top:var(--wp--preset--spacing--30);padding-right:var(--wp--preset--spacing--50);padding-bottom:var(--wp--preset--spacing--30);padding-left:var(--wp--preset--spacing--50)" class="wp-block-list is-style-dash-list has-bluebell-5-background-color has-background"> <li class="has-medium-font-size">Specialists in rodent and NHP preclinical efficacy and translational pharmacology studies</li> <li class="has-medium-font-size">Pharmacokinetic and biodistribution studies for small molecules and biologics, including gene therapies</li> <li class="has-medium-font-size">Support services, such as imaging, bioanalysis, etc</li> <li class="has-medium-font-size">Surgical excellence supporting model development, gene therapy/biologic evaluation, targeting of brain structures, PM tissue collection</li> <li class="has-medium-font-size">Bespoke endpoint assay development in addition to endpoints commonly employed in our models</li> </ul> </div> </div> <div class="wp-block-columns has-tangerine-20-background-color has-background is-layout-flex wp-container-core-columns-is-layout-5 wp-block-columns-is-layout-flex" style="padding-top:var(--wp--preset--spacing--30);padding-right:var(--wp--preset--spacing--60);padding-bottom:var(--wp--preset--spacing--30);padding-left:var(--wp--preset--spacing--60)"> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow" style="flex-basis:25%"></div> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow" style="flex-basis:50%"> <p class="has-large-font-size">“Atuka is a preclinical CRO that really stands out, having supported us on multiple preclinical studies. Their expertise in Parkinson’s disease and deep knowledge of the field, insight and feedback on the design of a study, as well as their reliable execution and attention to detail have been critical in supporting our drug discovery and development activities.”</p> <p><strong>– Iman Famili, CEO & President<br>Sinopia Biosciences</strong></p> </div> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow" style="flex-basis:25%"></div> </div> <div class="wp-block-columns animated fadeIn is-layout-flex wp-container-core-columns-is-layout-6 wp-block-columns-is-layout-flex" style="padding-top:var(--wp--preset--spacing--40);padding-right:var(--wp--preset--spacing--60);padding-bottom:var(--wp--preset--spacing--40);padding-left:var(--wp--preset--spacing--60)"> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow"> <p class="has-jacarta-50-color has-text-color has-link-color has-small-font-size wp-elements-f8d34b95f3d6bec8122fbb407f3d3dfc" style="padding-right:var(--wp--preset--spacing--20);padding-left:var(--wp--preset--spacing--20)">OUR PROMISE</p> <div style="height:8px" aria-hidden="true" class="wp-block-spacer"></div> <p class="animated fadeIn has-medium-font-size" style="padding-right:var(--wp--preset--spacing--20);padding-left:var(--wp--preset--spacing--20)">We support our partners in making informed, critical decisions at the interface between the preclinical and clinical—backed by our commitment to provide:</p> </div> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow" style="padding-right:var(--wp--preset--spacing--10);padding-left:var(--wp--preset--spacing--10)"> <div style="height:20px" aria-hidden="true" class="wp-block-spacer"></div> <div class="wp-block-group has-border-color has-jacarta-border-color wp-container-content-5 is-layout-flow wp-block-group-is-layout-flow" style="border-width:1px;padding-top:var(--wp--preset--spacing--10);padding-right:var(--wp--preset--spacing--10);padding-bottom:var(--wp--preset--spacing--10);padding-left:var(--wp--preset--spacing--10)"> <p class="animated fadeIn delay-1s has-large-font-size" style="padding-top:var(--wp--preset--spacing--10);padding-right:0;padding-bottom:var(--wp--preset--spacing--10);padding-left:0">Close collaboration with our partners’ scientists, putting Atuka’s unsurpassed expertise and knowledge at the service of their therapeutic development program.</p> </div> <div class="wp-block-group has-border-color has-jacarta-border-color wp-container-content-6 is-layout-flow wp-block-group-is-layout-flow" style="border-width:1px;padding-top:var(--wp--preset--spacing--10);padding-right:var(--wp--preset--spacing--10);padding-bottom:var(--wp--preset--spacing--10);padding-left:var(--wp--preset--spacing--10)"> <p class="animated fadeIn delay-2s has-large-font-size" style="padding-top:var(--wp--preset--spacing--10);padding-bottom:var(--wp--preset--spacing--10)">The widest range of industry-leading preclinical rodent and non-human primate models, enabling us to deliver the best-tailored approach for any therapeutic program.</p> </div> <div class="wp-block-group has-border-color has-jacarta-border-color wp-container-content-7 is-layout-flow wp-block-group-is-layout-flow" style="border-width:1px;padding-top:var(--wp--preset--spacing--10);padding-right:var(--wp--preset--spacing--10);padding-bottom:var(--wp--preset--spacing--10);padding-left:var(--wp--preset--spacing--10)"> <p class="animated fadeIn delay-2s has-large-font-size" style="padding-top:var(--wp--preset--spacing--10);padding-bottom:var(--wp--preset--spacing--10)">The highest-quality studies and data, as designed and interpreted by world-leading neuroscientists, to ensure results that are consistently predictive and translatable.</p> </div> </div> </div> <div class="wp-block-group has-tangerine-20-background-color has-background is-layout-flow wp-block-group-is-layout-flow" style="margin-top:0px;margin-bottom:0px;padding-top:var(--wp--preset--spacing--20);padding-right:var(--wp--preset--spacing--60);padding-bottom:var(--wp--preset--spacing--20);padding-left:var(--wp--preset--spacing--60)"> <div class="wp-block-query is-layout-flow wp-block-query-is-layout-flow"> <div style="height:6px" aria-hidden="true" class="wp-block-spacer"></div> <p class="has-jacarta-50-color has-text-color has-link-color has-small-font-size wp-elements-93c2499385c1ebf0f4bded3fa276ef40">ADDITIONAL INFORMATION ABOUT OUR SERVICES</p> <div class="wp-block-group is-layout-flow wp-block-group-is-layout-flow" style="margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--30);padding-right:0;padding-bottom:var(--wp--preset--spacing--30);padding-left:0"><ul class="columns-1 wp-block-post-template is-layout-grid wp-container-core-post-template-is-layout-1 wp-block-post-template-is-layout-grid"><li class="wp-block-post post-745 fact-sheet type-fact-sheet status-publish has-post-thumbnail hentry"> <div class="wp-block-group is-layout-flow wp-block-group-is-layout-flow" style="border-top-style:none;border-top-width:0px;border-right-style:none;border-right-width:0px;border-bottom-color:var(--wp--preset--color--jacarta);border-bottom-width:1px;border-left-style:none;border-left-width:0px;margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--10);padding-right:var(--wp--preset--spacing--30);padding-bottom:var(--wp--preset--spacing--10);padding-left:var(--wp--preset--spacing--30)"> <p class="align wp-block-atuka-factsheet"><a target="_blank" href="https://atuka.com/wp-content/uploads/2023/05/A4-handout-biodistribution_new-logo-1.pdf">Biodistribution in rodent and non-human primate</a></p> </div> </li><li class="wp-block-post post-747 fact-sheet type-fact-sheet status-publish has-post-thumbnail hentry tag-models"> <div class="wp-block-group is-layout-flow wp-block-group-is-layout-flow" style="border-top-style:none;border-top-width:0px;border-right-style:none;border-right-width:0px;border-bottom-color:var(--wp--preset--color--jacarta);border-bottom-width:1px;border-left-style:none;border-left-width:0px;margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--10);padding-right:var(--wp--preset--spacing--30);padding-bottom:var(--wp--preset--spacing--10);padding-left:var(--wp--preset--spacing--30)"> <p class="align wp-block-atuka-factsheet"><a target="_blank" href="https://atuka.com/wp-content/uploads/2023/05/A4-handout-6-OHDA-rodent_new-logo-2.pdf">Parkinson’s disease – Unilateral 6-OHDA-lesioned rodent models of dyskinesia</a></p> </div> </li><li class="wp-block-post post-749 fact-sheet type-fact-sheet status-publish has-post-thumbnail hentry tag-primates"> <div class="wp-block-group is-layout-flow wp-block-group-is-layout-flow" style="border-top-style:none;border-top-width:0px;border-right-style:none;border-right-width:0px;border-bottom-color:var(--wp--preset--color--jacarta);border-bottom-width:1px;border-left-style:none;border-left-width:0px;margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--10);padding-right:var(--wp--preset--spacing--30);padding-bottom:var(--wp--preset--spacing--10);padding-left:var(--wp--preset--spacing--30)"> <p class="align wp-block-atuka-factsheet"><a target="_blank" href="https://atuka.com/wp-content/uploads/2023/05/A4-handout-primate-services_V2_new-logo.pdf">Atuka’s Primate Services</a></p> </div> </li><li class="wp-block-post post-751 fact-sheet type-fact-sheet status-publish has-post-thumbnail hentry tag-models"> <div class="wp-block-group is-layout-flow wp-block-group-is-layout-flow" 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