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3.204.79.523 0 1.055-.06 1.593-.182a6.308 6.308 0 001.515-.549l.433 1.33a6.099 6.099 0 01-1.659.581c-.634.132-1.263.2-1.882.2-1.495 0-2.817-.328-3.965-.981a6.888 6.888 0 01-2.676-2.709c-.635-1.151-.953-2.46-.953-3.922 0-1.44.32-2.734.962-3.881a6.937 6.937 0 012.7-2.7c1.158-.653 2.49-.98 3.996-.98 1.453 0 2.75.31 3.893.93" id="Fill-9" fill="#FFF"/><path d="M4.869 35.513L19.88 23.764a1.38 1.38 0 011.7 0l15.012 11.749" id="Stroke-11" stroke="#FFF" stroke-width="1.5" stroke-linecap="round" stroke-linejoin="round"/></g></g></g></g></svg> </div> <div class="sticky-cta__link-wrapper"> <div class="sticky-cta__link"> <a class="btn btn--size-sm btn--style-simple has-primary-background-color is-style-Arrow-Right" href="https://www.pharmaron.com/contact-us/"> <span class="sticky-cta__link-text">Contact Us</span> </a> </div> </div> </div> <main id="main-content" class="main clearfix" role="main"> <article class="site-content clearfix"> <section class="masthead alignfull masthead--align-left masthead--quinary-xl" aria-label="Banner">  <div class="masthead__content-wrapper masthead__content-wrapper--no-triangle"> <div class="masthead__content"> <div class="breadcrumbs"><span><span><a href="https://www.pharmaron.com/">Home</a></span> » <span><a href="https://www.pharmaron.com/services/">Services</a></span> » <span><a href="https://www.pharmaron.com/services/clinical-development/">Clinical Development</a></span> » <span><a href="https://www.pharmaron.com/services/clinical-development/integrated-radiolabelled-sciences/">Integrated Radiolabelled Sciences</a></span> » <span><a href="https://www.pharmaron.com/services/clinical-development/integrated-radiolabelled-sciences/accelerator-mass-spectrometry-ams/">Accelerator Mass Spectrometry (AMS)</a></span> » <span class="breadcrumb_last" aria-current="page">AMS for Carbon-14 Non-clinical Studies</span></span></div> <h1 class="masthead__title h1">AMS for Carbon-14 Non-clinical Studies</h1> </div> </div>  <div class="masthead__media"> <picture> <source data-lazy-srcset="https://www.pharmaron.com/wp-content/uploads/2022/01/Non-Clinical-Studies-Using-Radiolabelled-Compounds-455x315.webp" media="(max-width: 480px)"> <img src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%20650%20450'%3E%3C/svg%3E" alt="Close-up of industrial equipment used in non-clinical studies with radiolabeled compounds, featuring metallic components, bolts, and precision engineering." data-lazy-srcset="https://www.pharmaron.com/wp-content/uploads/2022/01/Non-Clinical-Studies-Using-Radiolabelled-Compounds-650x450.webp 650w, https://www.pharmaron.com/wp-content/uploads/2022/01/Non-Clinical-Studies-Using-Radiolabelled-Compounds-455x315.webp 455w" width="650" height="450" data-lazy-src="https://www.pharmaron.com/wp-content/uploads/2022/01/Non-Clinical-Studies-Using-Radiolabelled-Compounds-650x450.webp" /><noscript><img src="https://www.pharmaron.com/wp-content/uploads/2022/01/Non-Clinical-Studies-Using-Radiolabelled-Compounds-650x450.webp" alt="Close-up of industrial equipment used in non-clinical studies with radiolabeled compounds, featuring metallic components, bolts, and precision engineering." srcset="https://www.pharmaron.com/wp-content/uploads/2022/01/Non-Clinical-Studies-Using-Radiolabelled-Compounds-650x450.webp 650w, https://www.pharmaron.com/wp-content/uploads/2022/01/Non-Clinical-Studies-Using-Radiolabelled-Compounds-455x315.webp 455w" width="650" height="450" /></noscript> </picture> </div> </section> <div class="wp-block-emagine-grid alignwide wp-block-emagine-grid--left-heavy em-mt--default"><div class="wp-block-emagine-grid__inner em-grid-equalHeight-alternateRows"> <div class="wp-block-emagine-column em-col-8_sm-12 em-mt--default"> <div class="wp-block-group em-mt--default"><div class="wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow"> <div id="block_b8e1450e7969aaca95ea97a64938aa0d" class="wp-block em-content-overlay em-mt--default em-mb--default alignfull"> <div class="em-content-overlay__inner alignwide"> <div class="wp-block-emagine-grid wp-block-emagine-grid--undefined em-mt--default"><div class="wp-block-emagine-grid__inner undefined-equalHeight"></div></div> </div> </div> </div></div> <h1 class="h5 em-mt--default">AMS for Carbon-14 Non-clinical Studies Services</h1> <p class="em-mt--default">The utilization of Accelerator Mass Spectrometry (AMS) in non-clinical studies is less common as high doses of <sup>14</sup>C radioactivity in animal models are generally not restricted by radiological safety concerns. AMS-enabled non-clinical applications typically focus on potent compounds where doses in animal models are correspondingly low, requiring the ultra-sensitivity for <sup>14</sup>C analysis that AMS provides.  By partnering with Pharmaron, we employ state-of-the-art AMS to generate the quantitative and qualitative data that helps to advance your development programs. </p> <p class="em-mt--default">AMS facilitates accurate quantitation of total [<sup>14</sup>C] and <sup>14</sup>C-parent/metabolite(s) in a wide range of sample types (blood, plasma, excreta, tissues, cells, biological fluids). The sensitivity of AMS analysis only requires very small (mg/µg) sample sizes. We also employ AMS in conjunction with HPLC/UPLC fractionation methods for metabolite profiling in all biological matrices.</p> <p class="em-mt--default">Radioanalysis can be integrated with Pharmaron’s radiosynthesis capabilities for radiolabelling both small and large molecules with <sup>14</sup>C.</p> </div> <div class="wp-block-emagine-column em-col-4_sm-12 em-mt--default"> <div id="block_d1e29d44b13160d779274243adc6d241" class="wp-block em-list-child-pages em-mt--default em-mb--default alignfull"> <div class="em-list-child-pages__wrapper"> <p class="h4 em-mt--default">Capabilities</p> <hr class="wp-block-separator is-style-wide em-mt--xs em-mb--xs" /> <div class="wp-block-emagine-button has-text-align-left is-style-Arrow-Right em-mt--default"> <a class="btn btn btn--size-sm btn--style-simple has-primary-background-color" href="https://www.pharmaron.com/services/clinical-development/integrated-radiolabelled-sciences/accelerator-mass-spectrometry-ams/carbon-14-microtracers/"> Carbon-14 Microtracers</a> </div> <hr class="wp-block-separator is-style-wide em-mt--xs em-mb--xs" /> <div class="wp-block-emagine-button has-text-align-left is-style-Arrow-Right em-mt--default"> <a class="btn btn btn--size-sm btn--style-simple has-primary-background-color" href="https://www.pharmaron.com/services/clinical-development/integrated-radiolabelled-sciences/accelerator-mass-spectrometry-ams/ultra-sensitive-ams/"> Ultra-sensitive AMS</a> </div> <hr class="wp-block-separator is-style-wide em-mt--xs em-mb--xs" /> <div class="wp-block-emagine-button has-text-align-left is-style-Arrow-Right em-mt--default"> <a class="btn btn btn--size-sm btn--style-simple has-primary-background-color" href="https://www.pharmaron.com/services/clinical-development/integrated-radiolabelled-sciences/accelerator-mass-spectrometry-ams/accelerated-carbon-14-clinical-programs/"> Accelerated Carbon-14 Clinical Programs</a> </div> <hr class="wp-block-separator is-style-wide em-mt--xs em-mb--xs" /> <div class="wp-block-emagine-button has-text-align-left is-style-Arrow-Right em-mt--default"> <a class="btn btn btn--size-sm btn--style-simple has-primary-background-color" href="https://www.pharmaron.com/services/clinical-development/integrated-radiolabelled-sciences/accelerator-mass-spectrometry-ams/phase-0-microdosing/"> Phase 0 Microdosing</a> </div> <hr class="wp-block-separator is-style-wide em-mt--xs em-mb--xs" /> <div class="wp-block-emagine-button has-text-align-left is-style-Arrow-Right em-mt--default"> <a class="btn btn btn--size-sm btn--style-simple has-primary-background-color" href="https://www.pharmaron.com/services/clinical-development/integrated-radiolabelled-sciences/accelerator-mass-spectrometry-ams/absolute-bioavailability-and-iv-pharmacokinetics/"> Absolute Bioavailability and IV Pharmacokinetics</a> </div> <hr class="wp-block-separator is-style-wide em-mt--xs em-mb--xs" /> <div class="wp-block-emagine-button has-text-align-left is-style-Arrow-Right em-mt--default"> <a class="btn btn btn--size-sm btn--style-simple has-primary-background-color" href="https://www.pharmaron.com/services/clinical-development/integrated-radiolabelled-sciences/accelerator-mass-spectrometry-ams/mass-balance-by-ams/"> Mass Balance by AMS</a> </div> <hr class="wp-block-separator is-style-wide em-mt--xs em-mb--xs" /> <div class="wp-block-emagine-button has-text-align-left is-style-Arrow-Right em-mt--default"> <a class="btn btn btn--size-sm btn--style-simple has-primary-background-color" href="https://www.pharmaron.com/services/clinical-development/integrated-radiolabelled-sciences/accelerator-mass-spectrometry-ams/metabolite-profiling-using-ams/"> Metabolite Profiling Using AMS</a> </div> <hr class="wp-block-separator is-style-wide em-mt--xs em-mb--xs" /> <div class="wp-block-emagine-button has-text-align-left is-style-Arrow-Right em-mt--default"> <a class="btn btn btn--size-sm btn--style-simple has-primary-background-color em-list-child-pages__current-page" href="https://www.pharmaron.com/services/clinical-development/integrated-radiolabelled-sciences/accelerator-mass-spectrometry-ams/ams-for-carbon-14-non-clinical-studies/"> AMS for Carbon-14 Non-clinical Studies</a> </div> <hr class="wp-block-separator is-style-wide em-mt--xs em-mb--xs" /> <div class="wp-block-emagine-button has-text-align-left is-style-Arrow-Right em-mt--default"> <a class="btn btn btn--size-sm btn--style-simple has-primary-background-color" href="https://www.pharmaron.com/services/clinical-development/integrated-radiolabelled-sciences/accelerator-mass-spectrometry-ams/carbon-14-radiolabels-and-ams-for-biologics/"> Carbon-14 Radiolabels and AMS for Biologics</a> </div> </div> </div> </div> </div></div> <div id="block_bd8f9b2ee751ed56fb8fdc0cdd9a0258" class="wp-block em-media-content em-mt--default em-mb--default alignwide"> <div class="em-media-content__inner em-media-content__inner--media-right"> <div class="em-media-content__media em-media-content__media--right"> <img fetchpriority="high" decoding="async" class="em-media-content__media-image" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%201120%20630'%3E%3C/svg%3E" alt="A scientist wearing a hijab, safety glasses, a white lab coat, and purple gloves is working with laboratory equipment. She holds a control panel in a lab filled with various scientific instruments and flasks, conducting preclinical ADME studies to assess genetic toxicology." data-lazy-srcset="https://www.pharmaron.com/wp-content/uploads/2022/01/scientist-ams-c14-non-clinical-studies-1120x630.webp 1120w, https://www.pharmaron.com/wp-content/uploads/2022/01/scientist-ams-c14-non-clinical-studies-2000x1125.webp 2000w, https://www.pharmaron.com/wp-content/uploads/2022/01/scientist-ams-c14-non-clinical-studies-1380x776.webp 1380w, https://www.pharmaron.com/wp-content/uploads/2022/01/scientist-ams-c14-non-clinical-studies-850x478.webp 850w, https://www.pharmaron.com/wp-content/uploads/2022/01/scientist-ams-c14-non-clinical-studies-640x360.webp 640w" width="1120" height="630" data-lazy-src="https://www.pharmaron.com/wp-content/uploads/2022/01/scientist-ams-c14-non-clinical-studies-1120x630.webp" /><noscript><img fetchpriority="high" decoding="async" class="em-media-content__media-image" src="https://www.pharmaron.com/wp-content/uploads/2022/01/scientist-ams-c14-non-clinical-studies-1120x630.webp" alt="A scientist wearing a hijab, safety glasses, a white lab coat, and purple gloves is working with laboratory equipment. She holds a control panel in a lab filled with various scientific instruments and flasks, conducting preclinical ADME studies to assess genetic toxicology." srcset="https://www.pharmaron.com/wp-content/uploads/2022/01/scientist-ams-c14-non-clinical-studies-1120x630.webp 1120w, https://www.pharmaron.com/wp-content/uploads/2022/01/scientist-ams-c14-non-clinical-studies-2000x1125.webp 2000w, https://www.pharmaron.com/wp-content/uploads/2022/01/scientist-ams-c14-non-clinical-studies-1380x776.webp 1380w, https://www.pharmaron.com/wp-content/uploads/2022/01/scientist-ams-c14-non-clinical-studies-850x478.webp 850w, https://www.pharmaron.com/wp-content/uploads/2022/01/scientist-ams-c14-non-clinical-studies-640x360.webp 640w" width="1120" height="630" /></noscript> </div> <div class="em-media-content__content em-media-content__content--left"> <div class="em-media-content__content-inner"> <h2 class="h5 em-mt--default"><strong><strong><strong>Preclinical Toxicology and Metabolism</strong></strong></strong></h2> <ul class="wp-block-list em-mt--default"> <li class="em-mt--default">ADME/PK</li> <li class="em-mt--default">Toxicokinetics – Bioanalysis of [<sup>14</sup>C]-parent compound</li> <li class="em-mt--default">Mass balance/metabolite profiling</li> </ul> <h2 class="has-white-color has-text-color h2 em-mt--default">0</h2> </div> </div> </div> </div> <div id="block_8ce9cf9a49e5f36d025d99321538894a" class="wp-block em-media-content em-mt--default em-mb--default alignwide"> <div class="em-media-content__inner em-media-content__inner--media-left"> <div class="em-media-content__media em-media-content__media--left"> <img decoding="async" class="em-media-content__media-image" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%201120%20630'%3E%3C/svg%3E" alt="Close-up of AMS equipment, focusing on the rotating wheel used in the analysis of biologics with carbon-14 radiolabels for ultra-sensitive detection." data-lazy-srcset="https://www.pharmaron.com/wp-content/uploads/2022/01/carbon-14-radiolabels-ams-biologics-2-1120x630.webp 1120w, https://www.pharmaron.com/wp-content/uploads/2022/01/carbon-14-radiolabels-ams-biologics-2-1380x776.webp 1380w, https://www.pharmaron.com/wp-content/uploads/2022/01/carbon-14-radiolabels-ams-biologics-2-850x478.webp 850w, https://www.pharmaron.com/wp-content/uploads/2022/01/carbon-14-radiolabels-ams-biologics-2-640x360.webp 640w" width="1120" height="630" data-lazy-src="https://www.pharmaron.com/wp-content/uploads/2022/01/carbon-14-radiolabels-ams-biologics-2-1120x630.webp" /><noscript><img decoding="async" class="em-media-content__media-image" src="https://www.pharmaron.com/wp-content/uploads/2022/01/carbon-14-radiolabels-ams-biologics-2-1120x630.webp" alt="Close-up of AMS equipment, focusing on the rotating wheel used in the analysis of biologics with carbon-14 radiolabels for ultra-sensitive detection." srcset="https://www.pharmaron.com/wp-content/uploads/2022/01/carbon-14-radiolabels-ams-biologics-2-1120x630.webp 1120w, https://www.pharmaron.com/wp-content/uploads/2022/01/carbon-14-radiolabels-ams-biologics-2-1380x776.webp 1380w, https://www.pharmaron.com/wp-content/uploads/2022/01/carbon-14-radiolabels-ams-biologics-2-850x478.webp 850w, https://www.pharmaron.com/wp-content/uploads/2022/01/carbon-14-radiolabels-ams-biologics-2-640x360.webp 640w" width="1120" height="630" /></noscript> </div> <div class="em-media-content__content em-media-content__content--right"> <div class="em-media-content__content-inner"> <h2 class="h5 em-mt--default"><strong><strong><strong>Target Turnover Studies</strong></strong></strong></h2> <ul class="wp-block-list em-mt--default"> <li class="em-mt--default">Assess “drugability” of therapeutic targets in preclinical models</li> <li class="em-mt--default"><sup>14</sup>C radiolabelled proteins and cytokines</li> <li class="em-mt--default">Targeting of tumor tissues in disease models</li> </ul> <h2 class="has-white-color has-text-color h2 em-mt--default">0</h2> </div> </div> </div> </div> <div id="block_98b54e4f95ca18a05ea9684d04662b87" class="wp-block em-media-content em-mt--default em-mb--default alignwide"> <div class="em-media-content__inner em-media-content__inner--media-right"> <div class="em-media-content__media em-media-content__media--right"> <img decoding="async" class="em-media-content__media-image" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%201120%20630'%3E%3C/svg%3E" alt="A gloved scientist adjusting a precision balance to measure a vial for Accelerator Mass Spectrometry (AMS) used in Carbon-14 non-clinical studies." data-lazy-srcset="https://www.pharmaron.com/wp-content/uploads/2022/01/ams-carbon14-nonclinical-studies-1120x630.webp 1120w, https://www.pharmaron.com/wp-content/uploads/2022/01/ams-carbon14-nonclinical-studies-2000x1125.webp 2000w, https://www.pharmaron.com/wp-content/uploads/2022/01/ams-carbon14-nonclinical-studies-1380x776.webp 1380w, https://www.pharmaron.com/wp-content/uploads/2022/01/ams-carbon14-nonclinical-studies-850x478.webp 850w, https://www.pharmaron.com/wp-content/uploads/2022/01/ams-carbon14-nonclinical-studies-640x360.webp 640w" width="1120" height="630" data-lazy-src="https://www.pharmaron.com/wp-content/uploads/2022/01/ams-carbon14-nonclinical-studies-1120x630.webp" /><noscript><img decoding="async" class="em-media-content__media-image" src="https://www.pharmaron.com/wp-content/uploads/2022/01/ams-carbon14-nonclinical-studies-1120x630.webp" alt="A gloved scientist adjusting a precision balance to measure a vial for Accelerator Mass Spectrometry (AMS) used in Carbon-14 non-clinical studies." srcset="https://www.pharmaron.com/wp-content/uploads/2022/01/ams-carbon14-nonclinical-studies-1120x630.webp 1120w, https://www.pharmaron.com/wp-content/uploads/2022/01/ams-carbon14-nonclinical-studies-2000x1125.webp 2000w, https://www.pharmaron.com/wp-content/uploads/2022/01/ams-carbon14-nonclinical-studies-1380x776.webp 1380w, https://www.pharmaron.com/wp-content/uploads/2022/01/ams-carbon14-nonclinical-studies-850x478.webp 850w, https://www.pharmaron.com/wp-content/uploads/2022/01/ams-carbon14-nonclinical-studies-640x360.webp 640w" width="1120" height="630" /></noscript> </div> <div class="em-media-content__content em-media-content__content--left"> <div class="em-media-content__content-inner"> <h2 class="h5 em-mt--default"><strong><strong><strong><strong>LC+AMS Bioanalysis and Total [<sup>14</sup>C] by AMS for Potent Molecules</strong></strong></strong></strong></h2> <ul class="wp-block-list is-style-two-column em-mt--default"> <li class="em-mt--default">ADCs</li> <li class="em-mt--default">Oligonucleotides</li> <li class="em-mt--default">Fusion proteins</li> <li class="em-mt--default">Peptides</li> <li class="em-mt--default">Polymers</li> </ul> <h2 class="has-white-color has-text-color h2 em-mt--default">0</h2> </div> </div> </div> </div> <div id="block_28feba9d12a462cd754894bc85d434ef" class="wp-block em-media-content em-mt--default em-mb--default alignwide"> <div class="em-media-content__inner em-media-content__inner--media-left"> <div class="em-media-content__media em-media-content__media--left"> <img decoding="async" class="em-media-content__media-image" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%201120%20630'%3E%3C/svg%3E" alt="A scientist reviews tissue distribution data on a computer screen, analyzing results from Carbon-14 non-clinical studies using AMS technology." data-lazy-srcset="https://www.pharmaron.com/wp-content/uploads/2022/01/carbon-14-nonclinical-ams-analysis-1120x630.webp 1120w, https://www.pharmaron.com/wp-content/uploads/2022/01/carbon-14-nonclinical-ams-analysis-1380x776.webp 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