Tompa Lab - Home

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<div class="node__content"> <div class="layout--layout-onecol tocbotized"> <div class="layout__region layout__region--content"> <div class="block block--layout-builder block--inline-blockbreadcrumbs" id="breadcrumbs-e1c"> </div> <div class="block block--entityone-layout-builder block--layout-builder-entity-labelnodepage container container--large block-layout-builder-entity-label page-title--hidden" id=""> <h1 class="page-title visually-hidden">Home</h1> </div> <div class="small-banner block-header-banner-block text-white no-overlay image-focus--" id="banner-block-3c4"> <div class="text-wrapper"> <div class="header-title"> <h1 class="spoof-h2 field field--name-field-title field--type-string title field__item">Tompa Lab</h1> </div> <div class="clearfix text-formatted field field--name-field-banner-intro field--type-text-long field--label-hidden field__item"><p>Laboratory of intrinsically disordered proteins (IDPs)<br> and liquid-liquid phase separation (LLPS)</p></div> </div> <div class="image-background"> <picture> <source srcset="/sites/tompalab.sites.vib.be/files/styles/small_header_image/public/2021-07/thul-A1800516-AE3A-444B-9488D1F84746CBF7.png.webp?itok=hG91-wS0 1x, /sites/tompalab.sites.vib.be/files/styles/small_header_image_x2/public/2021-07/thul-A1800516-AE3A-444B-9488D1F84746CBF7.png.webp?itok=HvfifLKC 2x" media="(min-width: 1024px)" type="image/webp" width="1340" height="250"/> <source srcset="/sites/tompalab.sites.vib.be/files/styles/small_header_image_small/public/2021-07/thul-A1800516-AE3A-444B-9488D1F84746CBF7.png.webp?itok=yzqYcOEB 1x, /sites/tompalab.sites.vib.be/files/styles/small_header_image/public/2021-07/thul-A1800516-AE3A-444B-9488D1F84746CBF7.png.webp?itok=hG91-wS0 2x" media="(min-width: 768px)" type="image/webp" width="670" height="125"/> <img src="/sites/tompalab.sites.vib.be/files/styles/small_header_image_small/public/2021-07/thul-A1800516-AE3A-444B-9488D1F84746CBF7.png.webp?itok=yzqYcOEB" width="670" height="125" alt="i" title="" loading="lazy" /> </picture> </div> </div> <div class="block block--layout-builder block--inline-blockimage-with-text media-position--left media-width--one-third has-text" id="image-with-text-943"> <div class="layout"> <div class="layout__item layout__item-image aos-init" data-aos=fade-right> <div class="blazy blazy--field blazy--field-image blazy--field-image--full field field--name-field-image field--type-entity-reference field--label-hidden field__items" data-blazy=""> <div class="field__item"> <div data-b-token="b-8878ec5cd3f" class="media media--blazy media--bundle--image media--image media--responsive media--ratio media--ratio--32 is-b-loading"> <picture> <source srcset="about:blank" media="(min-width: 768px)" type="image/webp" width="950" height="633" data-srcset="/sites/tompalab.sites.vib.be/files/styles/3_2_medium/public/2021-09/Peter_Tompa_3-2_0.jpg.webp?itok=qheJrmpC 1x"/> <source srcset="about:blank" media="(min-width: 0px)" type="image/webp" width="768" height="512" data-srcset="/sites/tompalab.sites.vib.be/files/styles/3_2_small/public/2021-09/Peter_Tompa_3-2_0.jpg.webp?itok=kJBOJgtb 1x"/> <img decoding="async" class="media__element b-lazy b-responsive" loading="auto" data-src="/sites/tompalab.sites.vib.be/files/2021-09/Peter_Tompa_3-2_0.jpg" src="data:image/svg+xml;charset=utf-8,%3Csvg%20xmlns%3D'http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg'%20viewBox%3D'0%200%201%201'%2F%3E" width="768" height="512" alt="Peter-Tompa" /> </picture> </div> </div> </div> <div class="field field--name-field-footnote field--type-string field--label-hidden note field__items"> <div class="field__item">Prof. Peter Tompa</div> </div> </div> <div class="layout__item layout__item-text aos-init" > <h2 class="field field--name-field-title field--type-string title field__item">Prof. Peter Tompa</h2> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p><strong>Short CV</strong></p> <ul> <li>Group leader at VIB and professor at VUB, since 2011</li> <li>Director of VIB-VUB CSB, 2011-2015</li> <li>Deputy director of Inst. Enzymology, Hungary, 2007-2009</li> <li>Group leader at Inst. Enzymology, Hungary, 2006-2011</li> <li>D.Sc. Hungarian Academy of Sciences, Budapest, Hungary, 2006</li> <li>Postdoc in ECUST Uni. (China) - Weizmann Inst. (Israel) - St. Jude Children's Hosp. (US) - Tokyo Uni. (Japan)</li> </ul></div> <div class="field field--name-field-link field--type-link field--label-hidden btn-wrapper field__item"> <a href="mailto: peter.tompa@vib.be" class="btn btn--dark btn--invert">Send an email</a> <a href="https://tompalab.sites.vib.be/en/contact" class="btn btn--dark btn--invert">Where we are</a> <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Tompa%20P%5BAuthor%5D&sort=date" class="btn btn--dark btn--invert">Full publication list</a> </div> </div> </div> </div> <div class="block block--layout-builder block--inline-blocktext-one-col aos-init" id="text-one-col-eee"> <h2 class="field field--name-field-title field--type-string title field__item">Our team</h2> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p><strong>Principal investigator:</strong> Peter Tompa<br> <strong>Postdoctoral subgroup leader:</strong> Tam谩s L谩z谩r<br> <strong>PhD researchers:</strong> Attila M茅sz谩ros, Kevin Muwonge, Giorgio Russo, Fernando Dur谩n Armenta, Nazanin Farahi<br> <strong>Co-superivised PhD researchers:</strong> Margot Van Nerom<br> <strong>Master students: </strong>Evagelos Efremidis, Bedri Batuhan Yaman<br> <strong>Lab manager:</strong> Mark Lackey</p></div> <div class="field field--name-field-link field--type-link field--label-hidden btn-wrapper field__item"> <a href="/en/team" class="btn btn--dark btn--invert">Meet our team</a> <a href="/en/alumni" class="btn btn--dark btn--invert">Click for alumni</a> <a href="/en/news" class="btn btn--dark btn--invert">News about our team</a> </div> </div> <div class="block block--layout-builder block--inline-blocktext-one-col aos-init" id="text-one-col-8c3"> <h2 class="field field--name-field-title field--type-string title field__item">Research focus in brief</h2> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p><span lang="EN">The study of structural disorder has already progressed way beyond simply establishing the disordered status of a protein. The current idea is that detailed experimental and theoretical characterization of the structural ensemble of disordered proteins in isolation, their structure in complex with their physiological partner(s), and the thermodynamics and kinetics of their interactions with their partners, whether stable (like in complexes) or fuzzy and transient (like in phase-separated bodies), hold the key to understanding these proteins and extending the structure鈥揻unction paradigm to the disordered state. In this spirit, we undertake three different lines of research to push the frontiers of the field of structural disorder. Our </span>studies have shown that structural disorder is prevalent in eukaryotic proteomes, disordered proteins carry out unique functions and they play important roles in serious diseases, such as cancer and neurodegeneration.</p> <p>Recently, the focus of the lab turned to understanding the role of structural disorder in liquid-liquid phase separation (LLPS) of proteins in cell physiology and disease, with a primary focus on amyotrophic lateral sclerosis (ALS).</p></div> <div class="field field--name-field-link field--type-link field--label-hidden btn-wrapper field__item"> <a href="https://tompalab.sites.vib.be/en/research" class="btn btn--dark btn--invert">Read more</a> <a href="https://tompalab.sites.vib.be/en/publications" class="btn btn--dark btn--invert">Publications</a> </div> </div> <div class="block block--layout-builder block--inline-blocktext-one-col aos-init" id="text-one-col-24d"> <h2 class="field field--name-field-title field--type-string title field__item">Sub-groups of the Tompa lab</h2> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p><em><strong>Experimental characterization of IDPs driving diseases and </strong></em><strong><span lang="EN-US"><em>biomolecular condensation</em></span></strong><br> led by <a href="/en"><strong>Peter Tompa</strong></a><br> current members: Attila Meszaros, Kevin Muwonge, Giorgio Russo, Fernando Dur谩n Armenta, Nazanin Farahi, Margot Van Nerom, Bedri Batuhan Yaman</p> <p><em><strong>Bio- and chemoinformatics analysis and computational modeling of proteins and protein complexes</strong></em><br> led by <a href="/en/team/tamas-lazar"><strong>Tam谩s L谩z谩r</strong></a><br> current members: Nazanin Farahi, Evagelos Efremidis, 脕lvaro Navarro (visiting), Galo E. Balatti (visiting)</p> <p> </p></div> </div> <div class="block block--layout-builder block--inline-blocktext-one-col aos-init" id="text-one-col-b69"> <h2 class="field field--name-field-title field--type-string title field__item">Applied experimental and computational techniques</h2> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><ul> <li><strong>Cloning / Protein expression / Protein purification</strong></li> <li><strong>Absorbance measurements / Microscopy / FRAP</strong></li> <li><strong>BLI / MST / ITC</strong></li> <li><strong>DLS / SAXS</strong></li> <li><strong>CD / NMR / X-ray crystallography</strong><br>  </li> <li><strong>Structure prediction / Docking / MD / Macromolecular modeling</strong></li> <li><strong>Chemoinformatics analysis of HTS data / QSAR modeling</strong></li> <li><strong>Systems biology data integration / Short linear peptide motif analysis</strong></li> <li><strong>Explorative analysis of biodata including clustering and machine learning</strong></li> </ul></div> </div> <div class="block block--layout-builder block--inline-blockseparator" id="separator-671"> <div class="separator"></div> </div> <div class="block block--layout-builder block--inline-blocktext-one-col aos-init" id="text-one-col-ced"> <h2 class="field field--name-field-title field--type-string title field__item">Consortia</h2> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>Besides our own research projects, our lab is member of several large consortium projects and international collaborations.</p></div> </div> <div class="block block--layout-builder block--inline-blockimage-with-text media-position--left media-width--one-fourth has-text" id="image-with-text-1df"> <div class="layout"> <div class="layout__item layout__item-image aos-init" > <div class="blazy blazy--field blazy--field-image blazy--field-image--full field field--name-field-image field--type-entity-reference field--label-hidden field__items" data-blazy=""> <div class="field__item"> <div data-b-token="b-fe364c4e132" class="media media--blazy media--bundle--image media--image media--responsive media--ratio media--ratio--32 is-b-loading"> <picture> <source srcset="about:blank" media="(min-width: 768px)" type="image/webp" width="950" height="633" data-srcset="/sites/tompalab.sites.vib.be/files/styles/3_2_medium/public/2021-09/Screenshot%202021-09-20%20at%2011.57.14.png.webp?itok=fkde2x1M 1x"/> <source srcset="about:blank" media="(min-width: 0px)" type="image/webp" width="768" height="512" data-srcset="/sites/tompalab.sites.vib.be/files/styles/3_2_small/public/2021-09/Screenshot%202021-09-20%20at%2011.57.14.png.webp?itok=AhUqW3dQ 1x"/> <img decoding="async" class="media__element b-lazy b-responsive" loading="auto" data-src="/sites/tompalab.sites.vib.be/files/2021-09/Screenshot%202021-09-20%20at%2011.57.14.png" src="data:image/svg+xml;charset=utf-8,%3Csvg%20xmlns%3D'http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg'%20viewBox%3D'0%200%201%201'%2F%3E" width="768" height="512" alt="PhasAGE" /> </picture> </div> </div> </div> </div> <div class="layout__item layout__item-text aos-init" > <h2 class="field field--name-field-title field--type-string title field__item">PhasAGE</h2> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>Excellence Hub on Phase Transitions in Aging and Age-Related Disorders</p> <p>Age-related diseases such as cancer and neurodegenerative disorders have become a public concern in Europe today due to the ageing population. The field of molecular biology is very promising for shedding light on late-onset diseases with a focus on incapacitating, age-related conditions. Portugal鈥檚 Instituto de Biologia Molecular e Celular (IBMC/i3S) has attracted international attention for its work in this domain. However, its scientists need to increase their competitivity in systems biology, bioinformatics and advanced biophysics. The EU-funded PhasAGE project will organise practical courses at the IBMC/i3S to offer the available knowledge in the field of phase transitions in ageing and age-related disorders. A unique collaborative network will be established between the IBMC/i3S, the Universities of Padua and Barcelona and the Vlaams Instituut voor Biotechnologie. Moreover, a European excellence hub will contribute to research and teaching quality.</p></div> <div class="field field--name-field-link field--type-link field--label-hidden btn-wrapper field__item"> <a href="https://phasage.eu/" class="btn btn--dark btn--invert">PhasAGE website</a> </div> </div> </div> </div> <div class="block block--layout-builder block--inline-blockimage-with-text media-position--left media-width--one-fourth has-text" id="image-with-text-6ea"> <div class="layout"> <div class="layout__item layout__item-image aos-init" > <div class="blazy blazy--field blazy--field-image blazy--field-image--full field field--name-field-image field--type-entity-reference field--label-hidden field__items" data-blazy=""> <div class="field__item"> <div data-b-token="b-deb1b70059f" class="media media--blazy media--bundle--image media--image media--responsive media--ratio media--ratio--32 is-b-loading"> <picture> <source srcset="about:blank" media="(min-width: 768px)" type="image/webp" width="950" height="633" data-srcset="/sites/tompalab.sites.vib.be/files/styles/3_2_medium/public/2022-07/cost-logo_0.jpg.webp?itok=1yYp2Goi 1x"/> <source srcset="about:blank" media="(min-width: 0px)" type="image/webp" width="768" height="512" data-srcset="/sites/tompalab.sites.vib.be/files/styles/3_2_small/public/2022-07/cost-logo_0.jpg.webp?itok=NoaijPzR 1x"/> <img decoding="async" class="media__element b-lazy b-responsive" loading="auto" data-src="/sites/tompalab.sites.vib.be/files/2022-07/cost-logo_0.jpg" src="data:image/svg+xml;charset=utf-8,%3Csvg%20xmlns%3D'http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg'%20viewBox%3D'0%200%201%201'%2F%3E" width="768" height="512" alt="COST" /> </picture> </div> </div> </div> </div> <div class="layout__item layout__item-text aos-init" > <h2 class="field field--name-field-title field--type-string title field__item">Non-globular proteins in the era of machine learning</h2> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>COST ACTION <a href="https://www.cost.eu/actions/CA21160">CA21160 - Non-globular proteins in the era of machine learning (ML4NGP)</a> aims to establish an interdisciplinary pan-European network to favour this interplay, fostering experimental frameworks designed to provide information to computational methods, and novel computational methods developed, trained and benchmarked with experimental data. ML4NGP will enhance the primary experimental data generation, promote integrative structural biology approaches, benchmark the state-of-the-art ML methods and improve the functional characterization of NGPs. The Action will support its scientific objectives through policies that sustain free knowledge exchange, inclusiveness and training of young researchers who will lead future innovations in this field.</p></div> </div> </div> </div> <div class="block block--layout-builder block--inline-blockimage-with-text media-position--left media-width--one-fourth has-text" id="image-with-text-53a"> <div class="layout"> <div class="layout__item layout__item-image aos-init" > <div class="blazy blazy--field blazy--field-image blazy--field-image--full field field--name-field-image field--type-entity-reference field--label-hidden field__items" data-blazy=""> <div class="field__item"> <div data-b-token="b-e0988dc0038" class="media media--blazy media--bundle--image media--image media--responsive media--ratio media--ratio--32 is-b-loading"> <picture> <source srcset="about:blank" media="(min-width: 768px)" type="image/webp" width="950" height="633" data-srcset="/sites/tompalab.sites.vib.be/files/styles/3_2_medium/public/2021-09/Elixir-Europe-logo-1.png.webp?itok=473tlePu 1x"/> <source srcset="about:blank" media="(min-width: 0px)" type="image/webp" width="768" height="512" data-srcset="/sites/tompalab.sites.vib.be/files/styles/3_2_small/public/2021-09/Elixir-Europe-logo-1.png.webp?itok=4OgSRpg0 1x"/> <img decoding="async" class="media__element b-lazy b-responsive" loading="auto" data-src="/sites/tompalab.sites.vib.be/files/2021-09/Elixir-Europe-logo-1.png" src="data:image/svg+xml;charset=utf-8,%3Csvg%20xmlns%3D'http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg'%20viewBox%3D'0%200%201%201'%2F%3E" width="768" height="512" alt="Elixir" /> </picture> </div> </div> </div> </div> <div class="layout__item layout__item-text aos-init" > <h2 class="field field--name-field-title field--type-string title field__item">ELIXIR - IDP Community</h2> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>The major goal of ELIXIR's IDP Community is to support the development of standards, tools and resources to accelerate the identification, analysis and functional characterisation of IDPs. Given their therapeutic relevance, IDR-mediated interactions are now seen as potential drug targets. A better understanding of their structure and function will help in developing new strategies to treat human diseases.</p></div> <div class="field field--name-field-link field--type-link field--label-hidden btn-wrapper field__item"> <a href="https://elixir-europe.org/communities/intrinsically-disordered-proteins" class="btn btn--dark btn--invert">ELIXIR - IDP Community webpage</a> </div> </div> </div> </div> <div class="block block--layout-builder block--inline-blockimage-with-text media-position--left media-width--one-fourth has-text" id="image-with-text-0a3"> <div class="layout"> <div class="layout__item layout__item-image aos-init" > <div class="blazy blazy--field blazy--field-image blazy--field-image--full field field--name-field-image field--type-entity-reference field--label-hidden field__items" data-blazy=""> <div class="field__item"> <div data-b-token="b-f0e95119eff" class="media media--blazy media--bundle--image media--image media--responsive media--ratio media--ratio--32 is-b-loading"> <picture> <source srcset="about:blank" media="(min-width: 768px)" type="image/webp" width="950" height="633" data-srcset="/sites/tompalab.sites.vib.be/files/styles/3_2_medium/public/2021-09/index.png.webp?itok=uHDjK6tX 1x"/> <source srcset="about:blank" media="(min-width: 0px)" type="image/webp" width="768" height="512" data-srcset="/sites/tompalab.sites.vib.be/files/styles/3_2_small/public/2021-09/index.png.webp?itok=MSchTbWK 1x"/> <img decoding="async" class="media__element b-lazy b-responsive" loading="auto" data-src="/sites/tompalab.sites.vib.be/files/2021-09/index.png" src="data:image/svg+xml;charset=utf-8,%3Csvg%20xmlns%3D'http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg'%20viewBox%3D'0%200%201%201'%2F%3E" width="768" height="512" alt="VUB" /> </picture> </div> </div> </div> </div> <div class="layout__item layout__item-text aos-init" > <h2 class="field field--name-field-title field--type-string title field__item">Dynamics of biocondensates</h2> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>The project entitled "<a href="https://researchportal.vub.be/en/projects/srp-onderzoekszwaartepunt-optical-and-microfluidic-tools-to-unrav">Optical and microfluidic tools to unravel the dynamics of bio-condensates</a>" was funded by the VUB Spearhead programme in the Strategic Research Project (SRP) category.<br> <span>Building on our prior experience with an SRP Growth funding project, we plan to combine state-of-the-art microfluidic approaches and optical detection for studying the phenomenon of biological condensation. We aim to develop novel chip designs for i) manipulating and visualizing sub- 渭 m particles, ii) creating special mixing regimes for studying equilibrium transient phenomena, and iii) observing nucleation phenomena on the surface or within droplets. These tools will help us to gain fundamental insight into the formation and evolution of liquid condensates and aggregates of proteins (e.g. TDP-43, hnRNP A2) related to amyotrophic lateral sclerosis (ALS) at the single-particle level. The synergy arising from this multidisciplinary approach will have a broad impact on various application domains. Not only will it provide a better understanding of the phenomenon of phase separation creating membraneless organelles (MLOs) in biology, it will also result in the development of generic microfluidic tools that can be used in studying a broad range of chemical and biological problems. Further, given the biomedical relevance of the molecular transitions under study, the novel insight will also foster the development of novel therapeutic approaches for treating age-related disorders.<br> The consortium is made up of four VUB groups, of Prof. Wim De Malsche, Prof. Heidi Ottevaere, Prof. Dominique Maes and Prof. Peter Tompa.</span></p></div> </div> </div> </div> <div class="block block--layout-builder block--inline-blockimage-with-text media-position--left media-width--one-fourth has-text" id="image-with-text-6cd"> <div class="layout"> <div class="layout__item layout__item-image aos-init" > <div class="blazy blazy--field blazy--field-image blazy--field-image--full field field--name-field-image field--type-entity-reference field--label-hidden field__items" data-blazy=""> <div class="field__item"> <div data-b-token="b-c90b00fa203" class="media media--blazy media--bundle--image media--image media--responsive media--ratio media--ratio--32 is-b-loading"> <picture> <source srcset="about:blank" media="(min-width: 768px)" type="image/webp" width="950" height="633" data-srcset="/sites/tompalab.sites.vib.be/files/styles/3_2_medium/public/2021-09/idpfun-padded-darkblue.png.webp?itok=-gwCfGLA 1x"/> <source srcset="about:blank" media="(min-width: 0px)" type="image/webp" width="768" height="512" data-srcset="/sites/tompalab.sites.vib.be/files/styles/3_2_small/public/2021-09/idpfun-padded-darkblue.png.webp?itok=CLtzIUo2 1x"/> <img decoding="async" class="media__element b-lazy b-responsive" loading="auto" data-src="/sites/tompalab.sites.vib.be/files/2021-09/idpfun-padded-darkblue.png" src="data:image/svg+xml;charset=utf-8,%3Csvg%20xmlns%3D'http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg'%20viewBox%3D'0%200%201%201'%2F%3E" width="768" height="512" alt="IDPfun" /> </picture> </div> </div> </div> </div> <div class="layout__item layout__item-text aos-init" > <h2 class="field field--name-field-title field--type-string title field__item">IDPfun (running out in 2023)</h2> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>Driving the functional characterization of intrinsically disordered proteins</p> <p>IDPfun is an international consortium aiming to extend our knowledge on the functions of IDPs. Starting from available state of the art computational tools and databases, which have been mostly developed by IDPfun participants, it aims drive a new level of IDP characterization leverage the complementary expertise of 5 EU MS and 3 TC institutions in Argentina, the latter providing useful complementary expertises. IDPfun will create a collaborative environment for research on novel ways to detect and characterize different IDP phenomena in their evolutionary context. It will develop an ontology and classification facilitating the comprehension of IDP complexity and aims to understand IDP functional mechanisms. The gained knowledge will be translated into major international protein databases for the benefit of the wider scientific community. Periodic meetings and symposia will generate a continuous knowledge exchange to be disseminated by open training schools and conferences. IDPfun will foster particularly young researchers, through dedicated activities and by ensuring adherence to the highest quality, ethics and gender balance standards. It is expected that IDPfun will strengthen overseas collaborations, focusing and coordinating research, leading to the creation of a sustainable international IDP community, driving knowledge and infrastructure in bioinformatics.</p></div> <div class="field field--name-field-link field--type-link field--label-hidden btn-wrapper field__item"> <a href="https://idpfun.eu/" class="btn btn--dark btn--invert">IDPfun website</a> </div> </div> </div> </div> <div class="block block--layout-builder block--inline-blockseparator" id="separator-109"> <div class="separator"></div> </div> <div class="block block--layout-builder block--inline-blocklogos logo" id="logos-e5b"> <div class="layout slider-off"> <div class="layout__item"> <h2 class="field field--name-field-title field--type-string title field__item">Funding and acknowledgements</h2> <div class="field field--name-field-logo field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div 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