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The effects of 17β-trenbolone and bisphenol A on sexual behavior and social dominance via the hypothalamic-pituitary-gonadal axis in male <span class="highlight-field">mice</span>. <em class='incite-journal-name' onclick='ShowInCiteJournal(169368);'>J Environ Sci (China)</em> 2025;<b>151</b>:54-67. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39481959' target='_blank'>39481959</a> DOI: <a href='https://dx.doi.org/10.1016/j.jes.2024.02.023' target='_blank'>10.1016/j.jes.2024.02.023</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1016%2fj.jes.2024.02.023%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 1</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1016%2fj.jes.2024.02.023')">Impact Index Per Article: 1.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.jes.2024.02.023','39481959', 'Mice')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(1);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(1);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(1);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.jes.2024.02.023' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(169368);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/24/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 02/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 02/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/03/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv1" value="10.1016/j.jes.2024.02.023" /> <div style="display: none" id="articleAbstract1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">17β-Trenbolone (17-TB) is well documented as an environmental endocrine disruptor in aquatic biological studies, but its effects on mammals remain poorly understood. Furthermore, 17-TB acts as a hormone with properties similar to testosterone, and the consequences of juvenile exposure on adult social behavior remain uncertain. Bisphenol A (BPA) acts as an estrogen-like hormone, compared to 17-TB. Three-week-old male Balb/c mice were exposed orally to 17-TB (100 µg/(kg·day)) and BPA (4 mg/(kg·day)) for 28 days. Assessments of social interactions and a three-chamber test showed that 17-TB increased virility in male mice, intensified both male and female sexual behavior, and attracted and accepted female mice. It also increased social dominance through tube tests in male mice and markedly activated the c-Fos+ immune response in the medial prefrontal cortex (mPFC) and basal amygdala (BLA). ELISA data showed that 17-TB and BPA exposure significantly affected serum gonadotropin-releasing hormone (GnRH), growth hormone (GH), estradiol (E2), and luteinizing hormone (LH) levels, as well as testicular lesions and androgen receptor (ARβ) and estrogen receptor (ERα) synthesis. Testicular transcriptomic analysis further confirmed that could disrupt steroid synthesis and linoleic acid-related biometabolic processes. These findings suggest the influence of 17-TB and BPA exposure on sexual behavior and fertility in male mice, possibly through modulation of the hypothalamic-pituitary-gonadal axis. This study provides insights relevant to human reproductive health and neuro-social behavioral research, and the potential risk of environmental disturbances should not be overlooked. </div> <a href="javascript:ShowArticleAbstract(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%2217%ce%b2-Trenbolone+(17-TB)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">17β-Trenbolone (17-TB)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bisphenol+A+(BPA)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bisphenol A (BPA)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sex+hormones%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sex hormones</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sexual+behavior%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sexual behavior</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Social+dominance%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Social dominance</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22hypothalamic-pituitary-gonadal+axis+(HPG)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">hypothalamic-pituitary-gonadal axis (HPG)</a></li></ul> <a href="javascript:ShowArticleKeywords(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Benzhydryl+Compounds%2ftoxicity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Benzhydryl Compounds/toxicity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phenols%2ftoxicity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phenols/toxicity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endocrine+Disruptors%2ftoxicity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endocrine Disruptors/toxicity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hypothalamo-Hypophyseal+System%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hypothalamo-Hypophyseal System/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+BALB+C%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred BALB C</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Social+Dominance%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Social Dominance</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Trenbolone+Acetate%2ftoxicity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Trenbolone Acetate/toxicity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sexual+Behavior%2c+Animal%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sexual Behavior, Animal/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hypothalamic-Pituitary-Gonadal+Axis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hypothalamic-Pituitary-Gonadal Axis</a></li></ul> <a href="javascript:ShowArticleMeSH(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(1);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow2"> <td style="min-width: 40px; text-align: center;"> 2 </td> <td> <div id="citation2" class="article-citation"> <b>Park SH</b>, Gye MC. Dibutyl phthalate disrupts [Ca<sup>2+</sup>]<sub>i</sub>, reactive oxygen species, [pH]<sub>i</sub>, protein kinases and mitochondrial activity, impairing sperm function. <em class='incite-journal-name' onclick='ShowInCiteJournal(169368);'>J Environ Sci (China)</em> 2025;<b>151</b>:68-78. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39481973' target='_blank'>39481973</a> DOI: <a href='https://dx.doi.org/10.1016/j.jes.2024.03.015' target='_blank'>10.1016/j.jes.2024.03.015</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.jes.2024.03.015','39481973', 'Mice')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(2);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(2);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(2);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.jes.2024.03.015' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(169368);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 11/24/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 03/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 03/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/03/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv2" value="10.1016/j.jes.2024.03.015" /> <div style="display: none" id="articleAbstract2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">To explore the mechanism of sperm dysfunction caused by dibutyl phthalate (DBP), the effects of DBP on intracellular [Ca2+] and [pH], reactive oxygen species (ROS), lipid peroxidation (LPO), mitochondrial permeability transition pore (mPTP) opening, mitochondrial membrane potential (MMP), adenosine triphosphate (ATP) levels, phosphorylation of protein kinase A (PKA) substrate proteins and phosphotyrosine (p-Tyr) proteins, sperm motility, spontaneous acrosome reaction, and tail bending were examined in mouse spermatozoa. At 100 µg/mL, DBP significantly increased tail bending and [Ca2+]i. Interestingly, DBP showed biphasic effects on [pH]i. DBP at 10-100 µg/mL significantly decreased sperm motility. Similarly, Ca2+ ionophore A23187 decreased [pH]i sperm motility, suggesting that DBP-induced excessive [Ca2+]i decreased sperm motility. DBP significantly increased ROS and LPO. DBP at 100 µg/mL significantly decreased mPTP closing, MMP, and ATP levels in spermatozoa, as did H2O2, indicative of ROS-mediated mitochondrial dysfunction caused by DBP. DBP as well as H2O2 increased p-Tyr sperm proteins and phosphorylated PKA substrate sperm proteins. DBP at 1-10 µg/mL significantly increased the spontaneous acrosome reaction, suggesting that DBP can activate sperm capacitation. Altogether, DBP showed a biphasic effect on intracellular signaling in spermatozoa. At concentrations relevant to seminal ortho-phthalate levels, DBP activates [pH]i, protein tyrosine kinases and PKA via physiological levels of ROS generation, potentiating sperm capacitation. DBP at high doses excessively raises [Ca2+]i and ROS and disrupts [pH]i, impairing the mitochondrial function, tail structural integrity, and sperm motility. </div> <a href="javascript:ShowArticleAbstract(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dibutyl+phthalate%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dibutyl phthalate</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mitochondria%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mitochondria</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+kinases%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein kinases</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reactive+oxygen+species+(ROS)+%5bCa(2%2b)%5d(i)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reactive oxygen species (ROS) [Ca(2+)](i)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sperm%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sperm</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22%5bpH%5d(i)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">[pH](i)</a></li></ul> <a href="javascript:ShowArticleKeywords(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reactive+Oxygen+Species%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reactive Oxygen Species/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Spermatozoa%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Spermatozoa/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dibutyl+Phthalate%2ftoxicity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dibutyl Phthalate/toxicity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sperm+Motility%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sperm Motility/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Calcium%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Calcium/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mitochondria%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mitochondria/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mitochondria%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mitochondria/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Membrane+Potential%2c+Mitochondrial%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Membrane Potential, Mitochondrial/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protein+Kinases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protein Kinases/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(2);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow3"> <td style="min-width: 40px; text-align: center;"> 3 </td> <td> <div id="citation3" class="article-citation"> <b>Wang K</b>, Sun Y, Zhu K, Liu Y, Zheng X, Yang Z, Man F, Huang L, Zhu Z, Huang Q, Li Y, Dong H, Zhao J, Li Y. Anti-pyroptosis biomimetic nanoplatform loading puerarin for myocardial infarction repair: From drug discovery to drug delivery. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122890. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39427429' target='_blank'>39427429</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122890' target='_blank'>10.1016/j.biomaterials.2024.122890</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122890','39427429', 'Mice')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(3);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(3);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(3);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122890' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/22/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv3" value="10.1016/j.biomaterials.2024.122890" /> <div style="display: none" id="articleAbstract3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Pyroptosis is a critical pathological mechanism implicated in myocardial damage following myocardial infarction (MI), and the crosstalk between macrophages and pyroptotic cardiomyocytes presents a formidable challenge for anti-pyroptosis therapies of MI. However, as single-target pyroptosis inhibitors frequently fail to address this crosstalk, the efficacy of anti-pyroptosis treatment post-MI remains inadequate. Therefore, the exploration of more potent anti-pyroptosis approaches is imperative for improving outcomes in MI treatment, particularly in addressing the crosstalk between macrophages and pyroptotic cardiomyocytes. Here, in response to this crosstalk, we engineered an anti-pyroptosis biomimetic nanoplatform (NM@PDA@PU), employing polydopamine (PDA) nanoparticles enveloped with neutrophil membrane (NM) for targeted delivery of puerarin (PU). Notably, network pharmacology is deployed to discern the most efficacious anti-pyroptosis drug (puerarin) among the 7 primary active monomers of TCM formulations widely applied in clinical practice and reveal the effect of puerarin on the crosstalk. Additionally, targeted delivery of puerarin could disrupt the malignant crosstalk between macrophages and pyroptotic cardiomyocytes, and enhance the effect of anti-pyroptosis by not only directly inhibiting cardiomyocytes pyroptosis through NLRP3-CASP1-IL-1β/IL-18 signal pathway, but reshaping the inflammatory microenvironment by reprogramming macrophages to anti-inflammatory M2 subtype. Overall, NM@PDA@PU could enhance anti-pyroptosis effect by disrupting the crosstalk between M1 macrophages and pyroptotic cardiomyocytes to protect cardiomyocytes, ameliorate cardiac function and improve ventricular remodeling, which providing new insights for the efficient treatment of MI. </div> <a href="javascript:ShowArticleAbstract(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Crosstalk%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Crosstalk</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophage+polarization%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophage polarization</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myocardial+infarction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myocardial infarction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Network+pharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Network pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Puerarin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Puerarin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pyroptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pyroptosis</a></li></ul> <a href="javascript:ShowArticleKeywords(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Isoflavones%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Isoflavones/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Isoflavones%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Isoflavones/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Isoflavones%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Isoflavones/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pyroptosis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pyroptosis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myocardial+Infarction%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myocardial Infarction/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myocytes%2c+Cardiac%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myocytes, Cardiac/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Delivery+Systems%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Delivery Systems</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polymers%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polymers/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Indoles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Indoles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomimetic+Materials%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomimetic Materials/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomimetic+Materials%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomimetic Materials/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RAW+264.7+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RAW 264.7 Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li></ul> <a href="javascript:ShowArticleMeSH(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(3);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow4"> <td style="min-width: 40px; text-align: center;"> 4 </td> <td> <div id="citation4" class="article-citation"> <b>Tan M</b>, Gao Z, Wang X, Wang X, Lin C, Huang Y, Chen W, Zhang Y, Hou Z. MnO<sub>2</sub>@CeO<sub>x</sub>-GAMP radiosensitizer with oxygen vacancies depended mimicking enzyme-like activities for radiosensitization-mediated STING pathway activation. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122797. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39255531' target='_blank'>39255531</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122797' target='_blank'>10.1016/j.biomaterials.2024.122797</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122797','39255531', 'Mice')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(4);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(4);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(4);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122797' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/31/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/31/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/12/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv4" value="10.1016/j.biomaterials.2024.122797" /> <div style="display: none" id="articleAbstract4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Activation of the stimulator of interferon genes (STING) pathway by radiotherapy (RT) has a significant effect on eliciting antitumor immune responses. The generation of hydroxyl radical (·OH) storm and the sensitization of STING-relative catalytic reactions could improve radiosensitization-mediated STING activation. Herein, multi-functional radiosensitizer with oxygen vacancies depended mimicking enzyme-like activities was fabricated to produce more dsDNA which benefits intracellular 2', 3'-cyclic GMP-AMP (cGAMP) generation, together with introducing exogenous cGAMP to activate immune response. MnO2@CeOx nanozymes present enhanced superoxide dismutase (SOD)-like and peroxidase (POD)-like activities due to induced oxygen vacancies accelerate the redox cycles from Ce4+ to Ce3+ via intermetallic charge transfer. CeOx shells not only serve as radiosensitizer, but also provide the conjugation site for AMP/GMP to form MnO2@CeOx-GAMP (MCG). Upon X-ray irradiation, MCG with SOD-like activity facilitates the conversion of superoxide anions generated by Ce-sensitization into H2O2 within tumor microenvironment (TME). The downstream POD-like activity catalyzes the elevated H2O2 into a profusion of ·OH for producing more damage DNA fragments. TME-responsive decomposed MCG could supply exogenous cGAMP, meanwhile the releasing Mn2+ improve the sensitivity of cyclic GMP-AMP synthase to dsDNA for producing more cGAMP, resulting in the promotion of STING pathway activation. </div> <a href="javascript:ShowArticleAbstract(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antitumor+immune+response%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antitumor immune response</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanozymes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanozymes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxygen+vacancy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxygen vacancy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Radiosensitization%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Radiosensitization</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stimulator+of+interferon+genes+pathways%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stimulator of interferon genes pathways</a></li></ul> <a href="javascript:ShowArticleKeywords(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Radiation-Sensitizing+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Radiation-Sensitizing Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Radiation-Sensitizing+Agents%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Radiation-Sensitizing Agents/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Manganese+Compounds%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Manganese Compounds/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Manganese+Compounds%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" 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effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Porphyrins%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Porphyrins/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Porphyrins%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Porphyrins/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomimetic+Materials%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomimetic Materials/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomimetic+Materials%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomimetic Materials/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nucleotides%2c+Cyclic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nucleotides, Cyclic</a></li></ul> <a href="javascript:ShowArticleMeSH(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(4);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow5"> <td style="min-width: 40px; text-align: center;"> 5 </td> <td> <div id="citation5" class="article-citation"> <b>Bhansali D</b>, Tu NH, Inoue K, Teng S, Li T, Tran HD, Kim DH, Dong J, Peach CJ, Sokrat B, Jensen DD, Dolan JC, Yamano S, Robinson VM, Bunnett NW, Albertson DG, Leong KW, Schmidt BL. PAR<sub>2</sub> on oral cancer cells and nociceptors contributes to oral cancer pain that can be relieved by nanoparticle-encapsulated AZ3451. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122874. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39418848' target='_blank'>39418848</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122874' target='_blank'>10.1016/j.biomaterials.2024.122874</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122874','39418848', 'Mice')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(5);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(5);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(5);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(5);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122874' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 09/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/19/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv5" value="10.1016/j.biomaterials.2024.122874" /> <div style="display: none" id="articleAbstract5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Oral cancer is notoriously painful. Activation of protease-activated receptor 2 (PAR2, encoded by F2RL1) by proteases in the cancer microenvironment is implicated in oral cancer pain. PAR2 is a G protein-coupled receptor (GPCR) expressed on neurons and cells in the cancer microenvironment. Sustained signaling of PAR2 from endosomes of neurons mediates sensitization and nociception. We focused on the differential contribution of PAR2 on oral cancer cells and neurons to oral cancer pain and whether encapsulation of a PAR2 inhibitor, AZ3451 in nanoparticles (NP) more effectively reverses PAR2 activation. We report that F2RL1 was overexpressed in human oral cancers and cancer cell lines. Deletion of F2RL1 on cancer cells reduced cancer-associated mechanical allodynia. A third-generation polyamidoamine dendrimer, functionalized with cholesterol was self-assembled into NPs encapsulating AZ3451. NP encapsulated AZ3451 (PAMAM-Chol-AZ NPs) more effectively reversed activation of PAR2 at the plasma membrane and early endosomes than free drug. The PAMAM-Chol-AZ NPs showed greater efficacy in reversing nociception than free drug, with respect to both level and duration, in three preclinical mouse models of oral cancer pain. The antinociceptive efficacy was confirmed with an operant orofacial assay. Genetic deletion of F2RL1 on cancer cells or F2rl1 on neurons each partially reversed mechanical cancer allodynia. The remaining nociception could be effectively reversed by PAMAM-Chol-AZ NPs. These findings suggest that PAR2 on oral cancer cells and neurons contribute to oral cancer nociception and NPs loaded with a PAR2 antagonist provide increased antinociception and improved oral function compared to free drug. </div> <a href="javascript:ShowArticleAbstract(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oral+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oral cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oral+cancer+pain%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oral cancer pain</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22PAR(2)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PAR(2)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protease-activated+receptor+2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protease-activated receptor 2</a></li></ul> <a href="javascript:ShowArticleKeywords(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+PAR-2%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, PAR-2/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mouth+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mouth Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mouth+Neoplasms%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mouth Neoplasms/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mouth+Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mouth Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cancer+Pain%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cancer Pain/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nociceptors%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nociceptors/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nociceptors%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nociceptors/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li></ul> <a href="javascript:ShowArticleMeSH(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIDCR+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 DE029694 NIDCR NIH HHS</a></li></ul> <a href="javascript:ShowArticleGrant(5);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow6"> <td style="min-width: 40px; text-align: center;"> 6 </td> <td> <div id="citation6" class="article-citation"> <b>Duong VT</b>, Dang TT, Le VP, Le TH, Nguyen CT, Phan HL, Seo J, Lin CC, Back SH, Koo KI. Direct extrusion of multifascicle prevascularized human skeletal muscle for volumetric muscle loss surgery. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122840. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39321685' target='_blank'>39321685</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122840' target='_blank'>10.1016/j.biomaterials.2024.122840</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122840','39321685', 'Mice')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(6);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(6);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(6);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122840' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/13/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/27/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv6" value="10.1016/j.biomaterials.2024.122840" /> <div style="display: none" id="articleAbstract6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Skeletal muscle is composed of multiple fascicles, which are parallel bundles of muscle fibers surrounded by connective tissues that contain blood vessels and nerves. Here, we fabricated multifascicle human skeletal muscle scaffolds that mimic the natural structure of human skeletal muscle bundles using a seven-barrel nozzle. For the core material to form the fascicle structure, human skeletal myoblasts were encapsulated in Matrigel with calcium chloride. Meanwhile, the shell that plays a role as the connective tissue, human fibroblasts and human umbilical vein endothelial cells within a mixture of porcine muscle decellularized extracellular matrix and sodium alginate at a 95:5 ratio was used. We assessed four types of extruded scaffolds monolithic-monoculture (Mo-M), monolithic-coculture (Mo-C), multifascicle-monoculture (Mu-M), and multifascicle-coculture (Mu-C) to determine the structural effect of muscle mimicking scaffold. The Mu-C scaffold outperformed other scaffolds in cell proliferation, differentiation, vascularization, mechanical properties, and functionality. In an in vivo mouse model of volumetric muscle loss, the Mu-C scaffold effectively regenerated the tibialis anterior muscle defect, demonstrating its potential for volumetric muscle transplantation. Our nozzle will be further used to produce other volumetric functional tissues, such as tendons and peripheral nerves. </div> <a href="javascript:ShowArticleAbstract(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Direct+extrusion%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Direct extrusion</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Functional+muscle+scaffold%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Functional muscle scaffold</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Human+skeletal+muscle%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Human skeletal muscle</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Multifascicle+muscle%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Multifascicle muscle</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prevascularization%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prevascularization</a></li></ul> <a href="javascript:ShowArticleKeywords(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tissue+Scaffolds%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tissue Scaffolds/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Muscle%2c+Skeletal%2fblood+supply%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Muscle, Skeletal/blood supply</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Human+Umbilical+Vein+Endothelial+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Human Umbilical Vein Endothelial Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tissue+Engineering%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tissue Engineering/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neovascularization%2c+Physiologic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neovascularization, Physiologic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Swine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Swine</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Proliferation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Proliferation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fibroblasts%2fcytology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fibroblasts/cytology</a></li></ul> <a href="javascript:ShowArticleMeSH(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(6);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow7"> <td style="min-width: 40px; text-align: center;"> 7 </td> <td> <div id="citation7" class="article-citation"> <b>Jin Z</b>, Zhang Y, Hu H, Li Q, Zhang L, Zhao K, Liu W, Li L, Gao C. Closed-loop theranostic microgels for immune microenvironment modulation and microbiota remodeling in ulcerative colitis. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122834. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39288617' target='_blank'>39288617</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122834' target='_blank'>10.1016/j.biomaterials.2024.122834</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122834','39288617', 'Mice')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(7);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(7);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(7);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122834' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/19/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv7" value="10.1016/j.biomaterials.2024.122834" /> <div style="display: none" id="articleAbstract7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Inflammatory bowel disease (IBD) is characterized by the upregulation of reactive oxygen species (ROS) and dysfunction of gut immune system, and microbiota. The conventional treatments mainly focus on symptom control with medication by overuse of drugs. There is an urgent need to develop a closed-loop strategy that combines in situ monitoring and precise treatment. Herein, we innovatively designed the 'cluster munition structure' theranostic microgels to realize the monitoring and therapy for ulcerative colitis (a subtype of IBD). The superoxide anion specific probe (tetraphenylethylene-coelenterazine, TPC) and ROS-responsive nanogels consisting of postbiotics urolithin A (UA) were loaded into alginate and ion-crosslinked to obtain the theranostic microgels. The theranostic microgels could be delivered to the inflammatory site, where the environment-triggered breakup of the microgels and release of the nanogels were achieved in sequence. The TPC-UA group had optimal results in reducing inflammation, repairing colonic epithelial tissue, and remodeling microbiota, leading to inflammation amelioration and recovery of tight junction between the colonic epithelium, and maintenance of gut microbiota. During the recovery process, the local chemiluminescence intensity, which is proportional to the degree of inflammation, was gradually inhibited. The cluster munition of theranostic microgels displayed promising outcomes in monitoring inflammation and precise therapy, and demonstrated the potential for inflammatory disease management. </div> <a href="javascript:ShowArticleAbstract(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammatory+bowel+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammatory bowel disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oral+administration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oral administration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Postbiotics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Postbiotics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ROS+monitoring%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ROS monitoring</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22theranostic+microgels%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">theranostic microgels</a></li></ul> <a href="javascript:ShowArticleKeywords(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colitis%2c+Ulcerative%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colitis, Ulcerative/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colitis%2c+Ulcerative%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colitis, Ulcerative/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Theranostic+Nanomedicine%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Theranostic Nanomedicine/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microgels%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microgels/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Microbiome%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Microbiome/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reactive+Oxygen+Species%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reactive Oxygen Species/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li></ul> <a href="javascript:ShowArticleMeSH(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(7);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow8"> <td style="min-width: 40px; text-align: center;"> 8 </td> <td> <div id="citation8" class="article-citation"> <b>Son YS</b>, Kwon YH, Lee MS, Kwon O, Jeong YJ, Mun SJ, Jeon S, Park JH, Han MH, Bae JS, Hur K, Jang AR, Park JH, Cho HS, Jung CR, Ryu CM, Son MJ, Park DS, Son MY. Helicobacter pylori VacA-induced mitochondrial damage in the gastric pit cells of the antrum and therapeutic rescue. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122842. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39383778' target='_blank'>39383778</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122842' target='_blank'>10.1016/j.biomaterials.2024.122842</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122842','39383778', 'Mice')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(8);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(8);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(8);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122842' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/15/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/13/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/11/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv8" value="10.1016/j.biomaterials.2024.122842" /> <div style="display: none" id="articleAbstract8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Exploring host cell specificity, pathogenicity, and molecular mechanisms of the vacuolating cytotoxin A (VacA), secreted by Helicobacter pylori (Hp) is crucial for developing novel treatment strategies. VacA affects subcellular events, particularly mitochondria, at a cell-type-specific level. However, the lack of reliable models that mimic VacA-induced subcellular damages and enable novel drug screening linked to the human stomach clinically limits our understanding of the mitochondrial networks in vivo. Here, human antrum gastric organoids (hAGOs) and tissue samples from Hp-infected patients were used to show the toxic effects of VacA-induced mitochondrial damage mainly in mucus-producing gastric pit cells by employing transcriptional, translational, and functional analyses. In VacA-intoxicated or Hp-infected hAGOs, robust mitochondrial fragmentation in gastric pit cells reduced ATP production during respiration, and loss of mucosal barrier integrity was first demonstrated experimentally. Using hAGOs, clinically relevant small molecules were screened for efficacy, and MLN8054, an Aurora kinase A inhibitor, reversed VacA-induced mitochondrial damage and loss of gastric epithelium integrity. MLN8054 was effective in VacA-treated and Hp-infected hAGOs and mice, highlighting hAGOs as a promising drug-screening model. These findings suggest that mitochondrial quality control may serve as a promising therapeutic target for Hp VacA-mediated toxicity and disease progression. </div> <a href="javascript:ShowArticleAbstract(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastric+pit+cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastric pit cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Helicobacter+pylori+VacA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Helicobacter pylori VacA</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Human+antrum+gastric+organoid%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Human antrum gastric organoid</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mitochondrial+dysfunction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mitochondrial dysfunction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mucus-producing+cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mucus-producing cells</a></li></ul> <a href="javascript:ShowArticleKeywords(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mitochondria%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mitochondria/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mitochondria%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mitochondria/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Helicobacter+pylori%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Helicobacter pylori</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bacterial+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bacterial Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Helicobacter+Infections%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Helicobacter Infections/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pyloric+Antrum%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pyloric Antrum/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pyloric+Antrum%2fmicrobiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pyloric Antrum/microbiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pyloric+Antrum%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pyloric Antrum/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastric+Mucosa%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastric Mucosa/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastric+Mucosa%2fmicrobiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastric Mucosa/microbiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastric+Mucosa%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastric Mucosa/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Organoids%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Organoids/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(8);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow9"> <td style="min-width: 40px; text-align: center;"> 9 </td> <td> <div id="citation9" class="article-citation"> <b>Kim HL</b>, Saravanakumar G, Lee S, Jang S, Kang S, Park M, Sobha S, Park SH, Kim SM, Lee JA, Shin E, Kim YJ, Jeong HS, Kim D, Kim WJ. Poly(β-amino ester) polymer library with monomer variation for mRNA delivery. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122896. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39426123' target='_blank'>39426123</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122896' target='_blank'>10.1016/j.biomaterials.2024.122896</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122896','39426123', 'Mice')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(9);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(9);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(9);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122896' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/24/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/15/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/21/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv9" value="10.1016/j.biomaterials.2024.122896" /> <div style="display: none" id="articleAbstract9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Non-viral vectors for mRNA delivery primarily include lipid nanoparticles (LNPs) and polymers. While LNPs are known for their high mRNA delivery efficiency, they can induce excessive immune responses and cause off-target effects, potentially leading to side effects. In this study, we aimed to explore polymer-based mRNA delivery systems as a viable alternative to LNPs, focusing on their mRNA delivery efficiency and potential application in mRNA vaccines. We created a library of poly(β-amino ester) (PBAE) polymers by combining various amine monomers and acrylate monomers. Through screening this polymer library, we identified specific polymer nanoparticles (PNPs) that demonstrated high mRNA expression efficiency, with sustained mRNA expression for up to two weeks. Furthermore, the PNPs showed mRNA expression only at the injection site and did not exhibit liver toxicity. Additionally, when assessing immune activation, the PNPs significantly induced T-cell immune activation and were effective in the plaque reduction neutralization test. These results suggest that polymer-based mRNA delivery systems not only hold potential for use in mRNA vaccines but also show promise for therapeutic applications. </div> <a href="javascript:ShowArticleAbstract(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Poly(%ce%b2-amino+ester)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Poly(β-amino ester)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polymer+library%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polymer library</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polymer+nanoparticles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polymer nanoparticles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mRNA+delivery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mRNA delivery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mRNA+vaccine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mRNA vaccine</a></li></ul> <a href="javascript:ShowArticleKeywords(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polymers%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polymers/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Messenger%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Messenger/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Transfer+Techniques%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Transfer Techniques</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li></ul> <a href="javascript:ShowArticleMeSH(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(9);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow10"> <td style="min-width: 40px; text-align: center;"> 10 </td> <td> <div id="citation10" class="article-citation"> <b>Li C</b>, Fang F, Wang E, Yang H, Yang X, Wang Q, Si L, Zhang Z, Liu X. Engineering extracellular vesicles derived from endothelial cells sheared by laminar flow for anti-atherosclerotic therapy through reprogramming macrophage. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122832. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39270628' target='_blank'>39270628</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122832' target='_blank'>10.1016/j.biomaterials.2024.122832</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122832','39270628', 'Mice')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(10);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(10);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(10);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122832' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/15/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv10" value="10.1016/j.biomaterials.2024.122832" /> <div style="display: none" id="articleAbstract10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Extracellular vesicles (EVs) secreted by endothelial cells in response to blood laminar flow play a crucial role in maintaining vascular homeostasis. However, the potential of these EVs to modulate the immune microenvironment within plaques for treating atherosclerosis remains unclear. Here, we present compelling evidence that EVs secreted by endothelial cells sheared by atheroprotective laminar shear stress (LSS-EVs) exhibit excellent immunoregulatory effects against atherosclerosis. LSS-EVs demonstrated a robust capacity to induce the conversion of M1-type macrophages into M2-type macrophages. Mechanistic investigations confirmed that LSS-EVs were enriched in miR-34c-5p and reprogrammed macrophages by targeting the TGF-β-Smad3 signaling pathway. Moreover, we employed click chemistry to modify hyaluronic acid (HA) on the surface of LSS-EVs, enabling specific binding to the CD44 receptor expressed by inflammatory macrophages within plaques. These HA-modified LSS-EVs (HA@LSS-EVs) exhibited exceptional abilities for targeting atherosclerosis and demonstrated promising therapeutic effects both in vitro and in vivo. </div> <a href="javascript:ShowArticleAbstract(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Atherosclerosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Atherosclerosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Extracellular+vesicles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Extracellular vesicles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Laminar+shear+stress%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Laminar shear stress</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophage+reprogramming%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophage reprogramming</a></li></ul> <a href="javascript:ShowArticleKeywords(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Extracellular+Vesicles%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Extracellular Vesicles/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Atherosclerosis%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Atherosclerosis/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Atherosclerosis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Atherosclerosis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Atherosclerosis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Atherosclerosis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyaluronic+Acid%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyaluronic Acid/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyaluronic+Acid%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyaluronic Acid/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cellular+Reprogramming%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cellular Reprogramming</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endothelial+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endothelial Cells/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Human+Umbilical+Vein+Endothelial+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Human Umbilical Vein Endothelial Cells/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RAW+264.7+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RAW 264.7 Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stress%2c+Mechanical%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stress, Mechanical</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transforming+Growth+Factor+beta%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transforming Growth Factor beta/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(10);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow11"> <td style="min-width: 40px; text-align: center;"> 11 </td> <td> <div id="citation11" class="article-citation"> <b>Gao M</b>, Sun Q, Zhang R, Shan G, Zhang H, Peng R, Liu M, Sun G, Qiao L, Li Y, He X. Extracellular vesicles-hitchhiking boosts the deep penetration of drugs to amplify anti-tumor efficacy. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122829. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39276410' target='_blank'>39276410</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122829' target='_blank'>10.1016/j.biomaterials.2024.122829</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122829','39276410', 'Mice')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(11);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(11);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(11);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122829' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/17/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv11" value="10.1016/j.biomaterials.2024.122829" /> <div style="display: none" id="articleAbstract11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Developing drug delivery systems capable of achieving deep tumor penetration is a challenging task, yet there is a significant demand for such systems in cancer treatment. Hitchhiking on tumor-derived extracellular vesicles (EVs) represents a promising strategy for enhancing drug penetration into tumors. However, the limited drug assembly on EVs restricts its further application. Here, we present a novel approach to efficiently attach antitumor drugs to EVs using an engineered cell membrane-based vector. This vector includes the AS1411 aptamer for tumor-specific targeting, the vesicular stomatitis virus glycoprotein (VSV-G) for tumor cell membrane fusion, and a photosensitizer as the therapeutic agent while ensuring optimal drug encapsulation and stability. Upon injection, photosensitizers are firstly transferred to the tumor cell membrane and subsequently piggybacked onto EVs with the inherent secretion process. By hitchhiking with EVs, photosensitizers can be transferred layer by layer deep into the solid tumors. The results suggest that this EVs-hitchhiking strategy enables photosensitizers to penetrate deeply into tumor tissue, thereby enhancing the efficacy of phototherapy. This study offers broad application prospects for delivering drugs deeply into tumor tissues. </div> <a href="javascript:ShowArticleAbstract(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Deep+penetration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Deep penetration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+delivery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug delivery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Engineering+cell+membrane+vesicles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Engineering cell membrane vesicles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Membrane+fusion%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Membrane fusion</a></li></ul> <a href="javascript:ShowArticleKeywords(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Extracellular+Vesicles%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Extracellular Vesicles/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Photosensitizing+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Photosensitizing Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antineoplastic+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antineoplastic Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Delivery+Systems%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Delivery Systems</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aptamers%2c+Nucleotide%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aptamers, Nucleotide/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Photochemotherapy%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Photochemotherapy/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+BALB+C%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred BALB C</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Nude%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Nude</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oligodeoxyribonucleotides%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oligodeoxyribonucleotides</a></li></ul> <a href="javascript:ShowArticleMeSH(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(11);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow12"> <td style="min-width: 40px; text-align: center;"> 12 </td> <td> <div id="citation12" class="article-citation"> <b>Jiang J</b>, Lu Y, Zheng X, Xie M, Jauković A, Gao M, Zheng H. Engineering probiotic biohydrogen micro-factories to initiate reductive stress for boosting tumor vulnerability. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122892. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39426122' target='_blank'>39426122</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122892' target='_blank'>10.1016/j.biomaterials.2024.122892</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122892','39426122', 'Mice')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(12);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(12);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122892' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/21/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv12" value="10.1016/j.biomaterials.2024.122892" /> <div style="display: none" id="articleAbstract12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Disruption of redox homeostasis profoundly affects cellular metabolism and activities. While oxidative stress is extensively studied in cancer therapies, research on reductive stress remains in its infancy. Molecular hydrogen (H2), a well-known antioxidant, holds significant potential to induce reductive stress due to its strong antioxidative properties, making it a promising candidate for cancer therapy. However, it remains a major challenge to develop a sustainable H2 delivery system in vivo. Herein, we designed a micro-factory by engineering a gel-based microcapsule that encapsulates Enterobacter aerogenes, a.k.a. probiotic biohydrogen microcapsules (PBMCs), enabling the sustained H2 generation within tumor microenvironment. Notably, PBMCs effectively suppressed the proliferation of eight tumor cell lines as well as drug-resistant cancer cells. The prolonged H2 release from PBMCs induced reductive stress, as evidenced by a significant increase in the GSH/GSSG ratio in 4T1 cells. Moreover, PBMCs displayed significant antitumor effects in breast, melanoma and liver cancer models. The inhibition of PI3K-AKT pathway and the activation of MAPK pathway were identified as key mechanisms responsible for inducing tumor cell cycle arrest and apoptosis. The PBMCs also exhibited synergistic effects in combination with chemotherapeutics, resulting in robust inhibitions of preinvasive carcinoma growth and commonly associated pulmonary metastasis. Overall, our study introduces an innovative strategy to manipulate reductive stress in the tumor microenvironment through in situ H2 generation, thereby enhancing tumor vulnerability. </div> <a href="javascript:ShowArticleAbstract(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hydrogen%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hydrogen/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Probiotics%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Probiotics/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+Stress%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative Stress/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+BALB+C%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred BALB C</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Microenvironment%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Microenvironment/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Capsules%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Capsules</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Proliferation%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Proliferation/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apoptosis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apoptosis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Enterobacter+aerogenes%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Enterobacter aerogenes/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antineoplastic+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antineoplastic Agents/pharmacology</a></li></ul> <a href="javascript:ShowArticleMeSH(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(12);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow13"> <td style="min-width: 40px; text-align: center;"> 13 </td> <td> <div id="citation13" class="article-citation"> <b>Shin Y</b>, Lee HS, Kim JU, An YH, Kim YS, Hwang NS, Kim DH. Functional-hydrogel-based electronic-skin patch for accelerated healing and monitoring of skin wounds. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122802. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39255530' target='_blank'>39255530</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122802' target='_blank'>10.1016/j.biomaterials.2024.122802</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122802','39255530', 'Mice')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(13);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(13);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122802' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/12/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv13" value="10.1016/j.biomaterials.2024.122802" /> <div style="display: none" id="articleAbstract13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Conductive hydrogels feature reasonable electrical performance as well as tissue-like mechanical softness, thus positioning them as promising material candidates for soft bio-integrated electronics. Despite recent advances in materials and their processing technologies, however, facile patterning and monolithic integration of functional hydrogels (e.g., conductive, low-impedance, adhesive, and insulative hydrogels) for all-hydrogel-based soft bioelectronics still poses significant challenges. Here, we report material design, fabrication, and integration strategies for an electronic-skin (e-skin) patch based on functional hydrogels. The e-skin patch was fabricated by using photolithography-compatible functional hydrogels, such as poly(2-hydroxyethyl acrylate) (PHEA) hydrogel (substrate), Ag flake hydrogel (interconnection; conductivity: ∼571.43 S/cm), poly(3,4-ethylenedioxythiophene:polystyrene) (PEDOT:PSS) hydrogel (working electrode; impedance: ∼69.84 Ω @ 1 Hz), polydopamine (PDA) hydrogel (tissue adhesive; shear strength: ∼725.1 kPa), and poly(vinyl alcohol) (PVA) hydrogel (encapsulation). The properties of these functional hydrogels closely resemble those of human tissues in terms of water content and Young's modulus, enabling stable tissue-device interfacing in dynamically changing physiological environments. We demonstrated the efficacy of the e-skin patch through its application to accelerated healing and monitoring of skin wounds in mouse models - efficient fibroblast migration, proliferation, and differentiation promoted by electric field (EF) stimulation and iontophoretic drug delivery, and monitoring of the accelerated healing process through impedance mapping. The all-hydrogel-based e-skin patch is expected to create new opportunities for various clinically-relevant tissue interfacing applications. </div> <a href="javascript:ShowArticleAbstract(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Wound+Healing%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Wound Healing/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hydrogels%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hydrogels/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Skin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Skin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Wearable+Electronic+Devices%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Wearable Electronic Devices</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transdermal+Patch%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transdermal Patch</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Electric+Conductivity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Electric Conductivity</a></li></ul> <a href="javascript:ShowArticleMeSH(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(13);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow14"> <td style="min-width: 40px; text-align: center;"> 14 </td> <td> <div id="citation14" class="article-citation"> <b>Luo J</b>, Shang Y, Zhao N, Lu X, Wang Z, Li X, Meng X, Zhao Y. Hypoxia-responsive <span class="highlight-field">mice</span>lles deprive cofactor of stearoyl-CoA desaturase-1 and sensitize ferroptotic ovarian cancer therapy. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122820. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39277948' target='_blank'>39277948</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122820' target='_blank'>10.1016/j.biomaterials.2024.122820</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122820','39277948', 'Mice')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(14);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(14);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(14);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122820' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/17/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv14" value="10.1016/j.biomaterials.2024.122820" /> <div style="display: none" id="articleAbstract14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Ferroptosis has been recognized as a promising therapeutic strategy for cancer due to its unique mechanism of action. However, the upregulation of stearoyl-CoA desaturase 1 (SCD1) in ovarian cancer leads to resistance to ferroptotic therapy. Zinc ion (Zn2+) serves as the cofactor of SCD1. It was hypothesized that selective deprivation of Zn2+ from SCD1 could sensitize ferroptotic ovarian cancer therapy. Here, we report a hypoxia-responsive polymer micelle for enhanced ferroptosis of ovarian cancer cells. A SCD1 inhibitor, PluriSIn 1 (Plu), and a ferroptosis inducer, Auranofin (Aur), were co-encapsulated in nitroimidazole-bearing micelles. Under the hypoxic tumor microenvironment, the conversion of nitroimidazole to aminoimidazole triggered the cargo release and induced the depletion of antioxidant molecules (e.g., glutathione, thioredoxin, and NADPH). Meanwhile, because of the strong coordination between aminoimidazole and Zn2+ compared to that of histidine and Zn2+, such conversion can deprive the metal cofactor of SCD1, hence sensitizing the action of Plu and Aur. The proof-of-concept was demonstrated in cell and animal models with minimal systemic toxicity. The current work integrates ferroptosis induction with SCD1 inhibition in a hypoxia-responsive vehicle, offering a promising strategy for addressing the ferroptosis resistance and opening novel avenues for managing the difficult-to-treat ovarian cancer. </div> <a href="javascript:ShowArticleAbstract(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ferroptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ferroptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hypoxia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hypoxia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Micelles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Micelles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanomedicine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanomedicine</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stearoyl-coA+desaturase-1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stearoyl-coA desaturase-1</a></li></ul> <a href="javascript:ShowArticleKeywords(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovarian+Neoplasms%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ovarian Neoplasms/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovarian+Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ovarian Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ovarian+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ovarian Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ferroptosis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ferroptosis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stearoyl-CoA+Desaturase%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stearoyl-CoA Desaturase/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stearoyl-CoA+Desaturase%2fantagonists+%26amp%3b+inhibitors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stearoyl-CoA Desaturase/antagonists & inhibitors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Micelles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Micelles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Nude%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Nude</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Zinc%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Zinc/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Zinc%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Zinc/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+BALB+C%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred BALB C</a></li></ul> <a href="javascript:ShowArticleMeSH(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(14);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow15"> <td style="min-width: 40px; text-align: center;"> 15 </td> <td> <div id="citation15" class="article-citation"> <b>Huang Y</b>, Xu J, Sun G, Cheng X, An Y, Yao X, Nie G, Zhang Y. Enteric-coated cerium dioxide nanoparticles for effective inflammatory bowel disease treatment by regulating the redox balance and gut microbiome. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122822. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39270625' target='_blank'>39270625</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122822' target='_blank'>10.1016/j.biomaterials.2024.122822</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122822','39270625', 'Mice')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(15);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(15);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(15);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122822' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/19/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/15/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv15" value="10.1016/j.biomaterials.2024.122822" /> <div style="display: none" id="articleAbstract15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Reactive oxygen species (ROS) play crucial roles in the pathogenesis of inflammatory bowel disease (IBD) by disrupting the mucosal barrier and subsequently leading to the dysregulation of the gut microbiome. Therefore, ROS scavengers present a promising and comprehensive strategy for the effective IBD treatment. In the current work, we explored the therapeutic potential of cerium dioxide (CeO2) nano-enzyme, which is well-known for their potent antioxidant properties and capability to mimic natural antioxidant enzymes in the regulation of oxidative stress. We developed a novel enteric-coated nanomedicine (CeO2@S100) aiming at improving the oral delivery efficacy of CeO2 in the complex gastrointestinal environment. CeO2@S100 is composed of a CeO2 nanoparticle core and a protective polyacrylic acid resin shell (Eudragit S100), ensuring targeted delivery of the core specifically at inflamed intestinal sites due to the negative surface charge. In vivo experiments revealed CeO2@S100 significantly alleviates the IBD by balancing oxidative stress and regulating gut microbiota in a dextran sulfate sodium-induced mouse colitis model. The uncomplicated synthesis of CeO2@S100 highlights its promise for clinical use, presenting an effective and safe approach to managing IBD. </div> <a href="javascript:ShowArticleAbstract(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CeO(2)+nano-enzyme%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CeO(2) nano-enzyme</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Eudragit+S100%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Eudragit S100</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammatory+bowel+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammatory bowel disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intestinal+microbiota+regulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intestinal microbiota regulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ROS+scavenger%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ROS scavenger</a></li></ul> <a href="javascript:ShowArticleKeywords(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cerium%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cerium/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cerium%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cerium/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Microbiome%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Microbiome/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammatory+Bowel+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammatory Bowel Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidation-Reduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidation-Reduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+Stress%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative Stress/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reactive+Oxygen+Species%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reactive Oxygen Species/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colitis%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colitis/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dextran+Sulfate%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dextran Sulfate</a></li></ul> <a href="javascript:ShowArticleMeSH(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(15);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow16"> <td style="min-width: 40px; text-align: center;"> 16 </td> <td> <div id="citation16" class="article-citation"> <b>Ghosh S</b>, Zheng M, He J, Wu Y, Zhang Y, Wang W, Shen J, Yeung KWK, Neelakantan P, Xu C, Qiao W. Electrically-driven drug delivery into deep cutaneous tissue by conductive microneedles for fungal infection eradication and protective immunity. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122908. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39454504' target='_blank'>39454504</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122908' target='_blank'>10.1016/j.biomaterials.2024.122908</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122908','39454504', 'Mice')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(16);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(16);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(16);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122908' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/13/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/28/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv16" value="10.1016/j.biomaterials.2024.122908" /> <div style="display: none" id="articleAbstract16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Fungal infections affect over 13 million people worldwide and are responsible for 1.5 million deaths annually. Some deep cutaneous fungal infections may extend the dermal barriers to cause systemic infection, resulting in substantial morbidity and mortality. However, the management of deep cutaneous fungal infection is challenging and yet overlooked by traditional treatments, which only offer limited drug availability within deep tissue. In this study, we have developed an electrically stimulated microneedle patch to deliver miconazole into the subcutaneous layer. We tested its antifungal efficacy using in vitro and ex vivo models that mimic fungal infection. Moreover, we confirmed its anti-fungal and wound-healing effects in a murine subcutaneous fungal infection model. Furthermore, our findings also showed that the combination of miconazole and applied current synergistically stimulated the nociceptive sensory nerves, thereby activating protective cutaneous immunity mediated by dermal dendritic and γδ-T cells. Collectively, this study provides a new strategy for minimally invasive delivery of therapeutic agents and the modulation of the neuro-immune axis in deep tissue. </div> <a href="javascript:ShowArticleAbstract(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antifungal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antifungal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Electroconductive+microneedle%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Electroconductive microneedle</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infected+wound+healing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infected wound healing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuro-immune+crosstalk%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuro-immune crosstalk</a></li></ul> <a href="javascript:ShowArticleKeywords(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Needles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Needles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antifungal+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antifungal Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antifungal+Agents%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antifungal Agents/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antifungal+Agents%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antifungal Agents/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Delivery+Systems%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Delivery Systems/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Miconazole%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Miconazole/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Miconazole%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Miconazole/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Skin%2fmicrobiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Skin/microbiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Electric+Conductivity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Electric Conductivity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Wound+Healing%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Wound Healing/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dermatomycoses%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dermatomycoses</a></li></ul> <a href="javascript:ShowArticleMeSH(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(16);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow17"> <td style="min-width: 40px; text-align: center;"> 17 </td> <td> <div id="citation17" class="article-citation"> <b>Xu Y</b>, Zhang J, Wang Z, Zhang P, Zhang Z, Yang Z, Lam JWY, Kwok RTK, Meng L, Dang D, Tang BZ. Water-soluble AIE photosensitizer in short-wave infrared region for albumin-enhanced and self-reporting phototheranostics. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122847. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39357148' target='_blank'>39357148</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122847' target='_blank'>10.1016/j.biomaterials.2024.122847</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122847','39357148', 'Mice')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(17);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(17);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(17);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122847' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/04/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/04/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv17" value="10.1016/j.biomaterials.2024.122847" /> <div style="display: none" id="articleAbstract17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Organic photosensitizers (PSs) play important roles in phototheranostics, and contribute to the fast development of precision medicine. However, water-soluble and highly emissive organic PSs, especially those emitting in the short-wave infrared region (SWIR), are still challenging. Also, it's difficult to prepare self-reporting PSs for visualizing the treatment via stimulated emission depletion (STED) nanoscopy. Thus, in this work, a water-soluble molecule of DTPAP-TBZ-I with aggregation-induced emission features is designed for the self-reporting photodynamic therapy (PDT) in an ultra-high resolution. In contrast to single molecule, its complex (DTPAP-TBZ-I@BSA) shows much enhanced fluorescence properties and reactive oxygen species (ROS) generation in SWIR window. Their photoluminescence quantum yield is determined to be ∼20.6 % and the enhancement of ROS generation is ∼18-fold. During the PDT, immigration of the complex from cytoplasm to nucleus is also observed via STED nanoscopy with a resolution of 66.11 nm, which allows self-report in the PDT treatment. DTPAP-TBZ-I@BSA is finally utilized for the imaging-guided PDT in vivo with a tumor inhibition rate of 84 %. This is the first work in albumin-enhanced water-soluble organic PSs in SWIR window for self-reporting phototheranostics at ultra-high resolutions, providing an ideal solution for the next generation of photosensitizers for precise medicine. </div> <a href="javascript:ShowArticleAbstract(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aggregation-induced+emission%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aggregation-induced emission</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Photodynamic+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Photodynamic therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Self-reporting%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Self-reporting</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Super-resolution+imaging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Super-resolution imaging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Water-soluble%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Water-soluble</a></li></ul> <a href="javascript:ShowArticleKeywords(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Photosensitizing+Agents%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Photosensitizing Agents/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Photosensitizing+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Photosensitizing Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Photochemotherapy%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Photochemotherapy/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Water%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Water/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Theranostic+Nanomedicine%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Theranostic Nanomedicine/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Solubility%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Solubility</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reactive+Oxygen+Species%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reactive Oxygen Species/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infrared+Rays%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infrared Rays</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+BALB+C%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred BALB C</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Nude%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Nude</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Serum+Albumin%2c+Bovine%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Serum Albumin, Bovine/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li></ul> <a href="javascript:ShowArticleMeSH(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(17);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow18"> <td style="min-width: 40px; text-align: center;"> 18 </td> <td> <div id="citation18" class="article-citation"> <b>Wang X</b>, Xue Y, Hao K, Peng B, Chen H, Liu H, Wang J, Cao J, Dong W, Zhang S, Yang Q, Li J, Lei W, Feng Y. Sustained therapeutic effects of self-assembled hyaluronic acid nanoparticles loaded with α-Ketoglutarate in various osteoarthritis stages. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122845. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39326362' target='_blank'>39326362</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122845' target='_blank'>10.1016/j.biomaterials.2024.122845</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122845','39326362', 'Mice')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(18);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(18);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(18);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122845' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/28/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv18" value="10.1016/j.biomaterials.2024.122845" /> <div style="display: none" id="articleAbstract18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Osteoarthritis (OA) is a prevalent degenerative disease characterized by irreversible destruction of articular cartilage, for which no current drugs are known to modify its progression. While intra-articular (IA) injections of hyaluronic acid (HA) offer temporary relief, their effectiveness and long-term benefits are debated. Alpha-ketoglutarate (αKG) has potential chondroprotective properties, but its use is limited by a short half-life and poor cartilage-targeting efficiency. Here, we developed self-assembled HA-αKG nanoparticles (NPs) to combine the benefits of both HA and αKG, showing stability, bioavailability, and sustained pH-responsive release in the knee joint. In both early and advanced OA stages in mice, HA, αKG, and HA-αKG NPs could relieve pain, enhance mobility, and reduce cartilage damage, with HA-αKG NPs demonstrating the best efficacy. Mechanistically, αKG not only promotes cartilage matrix synthesis but also inhibits degradation by activating the PERK-ATF4 signaling pathway to reduce endoplasmic reticulum stress (ERS) in chondrocytes. This study highlights the therapeutic potential of HA-αKG NPs for treating various OA stages, with efficient and sustained effects, suggesting rapid clinical adoption and high acceptability among clinicians and patients. </div> <a href="javascript:ShowArticleAbstract(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ATF4%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ATF4</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alpha-ketoglutarate%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alpha-ketoglutarate</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endoplasmic+reticulum%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endoplasmic reticulum</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyaluronic+acid%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyaluronic acid</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticle%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticle</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoarthritis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoarthritis</a></li></ul> <a href="javascript:ShowArticleKeywords(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyaluronic+Acid%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyaluronic Acid/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ketoglutaric+Acids%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ketoglutaric Acids/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ketoglutaric+Acids%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ketoglutaric Acids/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoarthritis%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoarthritis/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoarthritis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoarthritis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cartilage%2c+Articular%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cartilage, Articular/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cartilage%2c+Articular%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cartilage, Articular/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chondrocytes%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chondrocytes/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Delayed-Action+Preparations%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Delayed-Action Preparations/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li></ul> <a href="javascript:ShowArticleMeSH(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(18);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow19"> <td style="min-width: 40px; text-align: center;"> 19 </td> <td> <div id="citation19" class="article-citation"> <b>Yang H</b>, Wang W, Xiao J, Yang R, Feng L, Xu H, Xu L, Xing Y. ROS-responsive injectable hydrogels loaded with exosomes carrying miR-4500 reverse liver fibrosis. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122887. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39405826' target='_blank'>39405826</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122887' target='_blank'>10.1016/j.biomaterials.2024.122887</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122887','39405826', 'Mice')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(19);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(19);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(19);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122887' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/15/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/10/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv19" value="10.1016/j.biomaterials.2024.122887" /> <div style="display: none" id="articleAbstract19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The reversal of liver fibrosis requires effective strategies to reduce oxidative stress and inhibition of hepatic stellate cell (HSC) activation. MiR-4500 regulates pathological angiogenesis and collagen mRNA stability, with the potential to inhibit fibrosis. Herein, we explored the inhibition of HSC activation in vitro by exosomes (Exos) carrying miR-4500 and encapsulated ExosmiR-4500 in an intelligent injectable hydrogel with biological activity and reactive oxygen species (ROS) responsiveness for application in oxidative stress environments. Briefly, reversible boronic ester bonds were integrated into gelatin-based hydrogels through dynamic crosslinking of quaternized chitosan (QCS) and 4-carboxyphenylboronic acid (CPBA)-modified gelatin. The QCS-CPBA-Gelatin (QCG) hydrogel scavenged excess ROS from the local microenvironment and released ExosmiR-4500 through the dissociation of boronic ester bonds, providing a favorable microenvironment and in situ sustained-release drug delivery system for ExosmiR-4500. The results showed that QCG@ExosmiR-4500 hydrogel has biocompatibility, biodegradability, and slow-release ability, which could effectively clear ROS and inhibit HSC activation and pathological angiogenesis in vitro and in vivo. Furthermore, transcriptome analysis suggests that the pharmacological mechanism of the QCG@ExosmiR-4500 hydrogel is mainly related to anti-oxidation, anti-angiogenesis, anti-fibrosis processes, and signaling pathways. Thus, our study demonstrates that an intelligently responsive ExosmiR-4500 delivery system based on injectable hydrogels is a promising strategy for the treatment of liver fibrosis. </div> <a href="javascript:ShowArticleAbstract(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Exosomes+loading%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Exosomes loading</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Injectable+hydrogels%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Injectable hydrogels</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+fibrosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver fibrosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reactive+oxygen+species%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reactive oxygen species</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Responsive%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Responsive</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22miRNA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">miRNA</a></li></ul> <a href="javascript:ShowArticleKeywords(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hydrogels%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hydrogels/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Exosomes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Exosomes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reactive+Oxygen+Species%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reactive Oxygen Species/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Cirrhosis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Cirrhosis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver+Cirrhosis%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver Cirrhosis/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hepatic+Stellate+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hepatic Stellate Cells/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hepatic+Stellate+Cells%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hepatic Stellate Cells/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Injections%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Injections</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+Stress%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative Stress/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chitosan%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chitosan/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gelatin%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gelatin/chemistry</a></li></ul> <a href="javascript:ShowArticleMeSH(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(19);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow20"> <td style="min-width: 40px; text-align: center;"> 20 </td> <td> <div id="citation20" class="article-citation"> <b>Mahanty M</b>, Dutta B, Ou W, Zhu X, Bromberg JS, He X, Rahaman SO. Macrophage microRNA-146a is a central regulator of the foreign body response to biomaterial implants. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122855. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39362025' target='_blank'>39362025</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11560625' target='_blank'>PMC11560625</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122855' target='_blank'>10.1016/j.biomaterials.2024.122855</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122855','39362025', 'Mice')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(20);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(20);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(20);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(20);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122855' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/05/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv20" value="10.1016/j.biomaterials.2024.122855" /> <div style="display: none" id="articleAbstract20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Host recognition and immune-mediated foreign body response (FBR) to biomaterials can adversely affect the functionality of implanted materials. FBR presents a complex bioengineering and medical challenge due to the lack of current treatments, making the detailed exploration of its molecular mechanisms crucial for developing new and effective therapies. To identify key molecular targets underlying the generation of FBR, here we perform analysis of microRNAs (miR) and mRNAs responses to implanted biomaterials. We found that (a) miR-146a levels inversely affect macrophage accumulation, foreign body giant cell (FBGC) formation, and fibrosis in a murine implant model; (b) macrophage-derived miR-146a is a crucial regulator of the FBR and FBGC formation, as confirmed by global and cell-specific knockout of miR-146a; (c) miR-146a modulates genes related to inflammation, fibrosis, and mechanosensing; (d) miR-146a modulates tissue stiffness near the implant during FBR as assessed by atomic force microscopy; and (e) miR-146a is linked to F-actin production and cellular traction force induction as determined by traction force microscopy, which are vital for FBGC formation. These novel findings suggest that targeting macrophage miR-146a could be a selective strategy to inhibit FBR, potentially improving the biocompatibility of biomaterials. </div> <a href="javascript:ShowArticleAbstract(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomaterials%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomaterials</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Foreign+body+response%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Foreign body response</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Giant+cell%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Giant cell</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22miR-146a%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">miR-146a</a></li></ul> <a href="javascript:ShowArticleKeywords(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Foreign-Body+Reaction%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Foreign-Body Reaction/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biocompatible+Materials%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biocompatible Materials/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Giant+Cells%2c+Foreign-Body%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Giant Cells, Foreign-Body/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prostheses+and+Implants%2fadverse+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prostheses and Implants/adverse effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fibrosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fibrosis</a></li></ul> <a href="javascript:ShowArticleMeSH(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIAID+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 AI172086 NIAID NIH HHS</a></li></ul> <a href="javascript:ShowArticleGrant(20);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow21"> <td style="min-width: 40px; text-align: center;"> 21 </td> <td> <div id="citation21" class="article-citation"> <b>Chen W</b>, Zhang Y, Miao G, Ying Y, Ren Z, Sun X, Cai J, Shen H, Lu H. The augment effects of magnesium hydride on the lipid lowering effect of atorvastatin: an in vivo and in vitro investigation. <em class='incite-journal-name' onclick='ShowInCiteJournal(167990);'>Med Gas Res</em> 2025;<b>15</b>:148-155. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39436189' target='_blank'>39436189</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11515074' target='_blank'>PMC11515074</a> DOI: <a href='https://dx.doi.org/10.4103/mgr.medgasres-d-23-00047' target='_blank'>10.4103/mgr.medgasres-d-23-00047</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.4103/mgr.medgasres-d-23-00047','39436189', 'Mice')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(21);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(21);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(21);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.4103/mgr.medgasres-d-23-00047' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(167990);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 11/22/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 12/18/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 02/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/23/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv21" value="10.4103/mgr.medgasres-d-23-00047" /> <div style="display: none" id="articleAbstract21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">There is strong evidence connecting increased serum lipid levels to cardiovascular disorders, including atherosclerosis. Statins is prescribed as the primary medication to decrease lipid levels. Recent research has demonstrated that hydrogen possesses anti-inflammatory and antioxidant properties by modulating the expression of peroxisome proliferator-activated receptor gamma coactivator-1α, ultimately leading to the preservation of lipid homeostasis. Magnesium hydride (MgH2) is a prolonged stable hydrogen storage medium, which can be utilized to investigate its synergistic lipid-lowering effect with statins and its detailed molecular mechanism, both in vivo and in vitro. To ascertain the safety and efficacy of MgH2, we executed a comprehensive research of its influence on both physiological and pathological metrics. We noted a substantial diminution in lipid levels when MgH2 was integrated with atorvastatin, as attested by oil red staining. Furthermore, we scrutinized the regulatory effect of MgH2 on cytochrome P450 3A, which is a metabolic enzyme of statins, and discovered that it could be reduced by the MgH2. Concluding from our results, we propose that MgH2 inhibits the expression of cytochrome P450 3A in the liver and exerts an auxiliary lipid-lowering effect by increasing the blood concentration of statins. By augmenting our comprehension of MgH2's role in ameliorating lipid metabolism, we aspire to develop more promising therapies in the future. </div> <a href="javascript:ShowArticleAbstract(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22atorvastatin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">atorvastatin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22blood+lipids%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">blood lipids</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cholesterol%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cholesterol</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cyp3a%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cyp3a</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22high-fat+diet%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">high-fat diet</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22hydrogen%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">hydrogen</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22magnesium+hydride%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">magnesium hydride</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22triglycerides%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">triglycerides</a></li></ul> <a href="javascript:ShowArticleKeywords(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Atorvastatin%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Atorvastatin/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hydrogen%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hydrogen/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hydrogen%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hydrogen/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipids%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipids/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Magnesium+Compounds%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Magnesium Compounds/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Magnesium+Compounds%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Magnesium Compounds/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipid+Metabolism%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipid Metabolism/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liver%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liver/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Synergism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Synergism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hypolipidemic+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hypolipidemic Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hypolipidemic+Agents%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hypolipidemic Agents/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hypolipidemic+Agents%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hypolipidemic Agents/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li></ul> <a href="javascript:ShowArticleMeSH(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(21);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow22"> <td style="min-width: 40px; text-align: center;"> 22 </td> <td> <div id="citation22" class="article-citation"> <b>Li H</b>, Wang Z, Hu Y, He G, Huang L, Liu Y, Wang ZL, Jiang P. Enhancing CAR-T cell therapy against solid tumor by drug-free triboelectric immunotherapy. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122871. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39368275' target='_blank'>39368275</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122871' target='_blank'>10.1016/j.biomaterials.2024.122871</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122871','39368275', 'Mice')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(22);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(22);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(22);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122871' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/07/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv22" value="10.1016/j.biomaterials.2024.122871" /> <div style="display: none" id="articleAbstract22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Chimeric antigen receptor (CAR) T cell therapy is a highly effective immunotherapy for hematological tumors, but its efficacy against most solid tumors remains challenging. Herein, a novel synergistic combination therapy of drug-free triboelectric immunotherapy and CAR-T cell therapy against solid tumor was proposed. A triboelectric nanogenerator (TENG) that can generate pulsed direct-current by coupling triboelectrification effect and electrostatic breakdown effect was fabricated. The TENG can generate up to 30 pulse direct-current peaks with peak current output ≈35 μA in a single sliding to power the triboelectric immunotherapy. The pulsed direct-current stimulation induced immunogenic cell death of tumor cells (survival rate of 35.9 %), which promoted dendritic cells maturation, accelerated the process of antigen presentation to CAR-T cells and enhanced the systemic adaptive immune response. Furthermore, triboelectric immunotherapy promoted M1-like macrophage polarization, reduced regulatory T cells differentiation and reprogrammed the tumor immunosuppressive microenvironment, which ultimately enhanced the efficacy of CAR-T cells to eradicate nearly 60 % of NALM6 solid tumor mass. Notably, considering that triboelectric immunotherapy is a safe and effective drug-free antitumor strategy, the combined therapy did not increase the burden of double-medication on patients. </div> <a href="javascript:ShowArticleAbstract(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CAR-T+cell%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CAR-T cell</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunosuppressive+microenvironment%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunosuppressive microenvironment</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Solid+tumor+treatment%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Solid tumor treatment</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Triboelectric+immunotherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Triboelectric immunotherapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Triboelectric+nanogenerator%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Triboelectric nanogenerator</a></li></ul> <a href="javascript:ShowArticleKeywords(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptors%2c+Chimeric+Antigen%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptors, Chimeric Antigen/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2c+Adoptive%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy, Adoptive/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Microenvironment%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Microenvironment/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22T-Lymphocytes%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">T-Lymphocytes/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li></ul> <a href="javascript:ShowArticleMeSH(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(22);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow23"> <td style="min-width: 40px; text-align: center;"> 23 </td> <td> <div id="citation23" class="article-citation"> <b>Foo LLE</b>, Logeshwari MN, Czarny B, Ng KW. Development of keratin-based fibers fabricated by interfacial polyelectrolyte complexation for suture applications. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122878. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39393217' target='_blank'>39393217</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122878' target='_blank'>10.1016/j.biomaterials.2024.122878</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122878','39393217', 'Mice')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(23);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(23);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(23);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122878' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/13/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv23" value="10.1016/j.biomaterials.2024.122878" /> <div style="display: none" id="articleAbstract23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Interfacial Polyelectrolyte Complexation (IPC) is a convenient way to produce composite, micro-scale fibers. In this paper, we report the successful development of novel keratin-based IPC fibers and also demonstrate the feasibility of using these fibers as sutures through a proof-of-concept in vivo study. Two composite fibers were produced: chitosan-keratin (CK) and keratin-keratin (KK). These fibers were evaluated for their physico-chemical, mechanical and biochemical properties. In the dry state, the CK fiber had a greater Young's modulus of about 2 GPa while the KK fiber registered a longer strain-at-break of about 100 % due to the strain-stiffening effect. Notably, the keratins were found to assemble into amyloids within the composite fibers based on Congo red staining and Wide-Angle X-Ray Scattering. Functionally, both fibers were malleable could be weaved, braided and knotted. When used as sutures to close incisional wounds in mice over 21 days, these fibers were found to elicit minimal host tissue response and were partially degraded over the duration. Interestingly, the KK fiber evoked a lower extent of immune cell response and fibrous capsule encapsulation that was comparable to commercial, non-absorbable Dafilon® sutures. This work demonstrated the possibility of producing keratin-based IPC fibers which may find practicality as medical sutures. </div> <a href="javascript:ShowArticleAbstract(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Human+hair%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Human hair</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Interfacial+polyelectrolyte+complexation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Interfacial polyelectrolyte complexation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Keratins%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Keratins</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sutures%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sutures</a></li></ul> <a href="javascript:ShowArticleKeywords(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Keratins%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Keratins/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sutures%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sutures</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chitosan%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chitosan/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Electrolytes%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Electrolytes/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Materials+Testing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Materials Testing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tensile+Strength%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tensile Strength</a></li></ul> <a href="javascript:ShowArticleMeSH(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(23);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow24"> <td style="min-width: 40px; text-align: center;"> 24 </td> <td> <div id="citation24" class="article-citation"> <b>Liu L</b>, Ding M, Zheng M, Xu G, Gao L, Yang W, Wei Z, Shang J, Wang L, Wang H, Gao F. Transformable peptide blocks NF-κB/IκBα pathway through targeted coating IκBα against rheumatoid arthritis. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122839. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39288618' target='_blank'>39288618</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122839' target='_blank'>10.1016/j.biomaterials.2024.122839</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122839','39288618', 'Mice')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(24);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(24);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(24);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122839' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/28/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/19/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv24" value="10.1016/j.biomaterials.2024.122839" /> <div style="display: none" id="articleAbstract24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Rheumatoid arthritis (RA) is an autoimmune disease characterized by destructive effects. Although current therapies utilizing antibodies against inflammatory cytokines have shown some success, the inhibition of a single inflammatory molecule may not suffice to impede the progression of RA due to the intricate pathogenesis involving multiple molecules. In this study, we have developed an intelligent transformable peptide, namely BP-FFVLK-DSGLDSM (BFD). BFD has the ability to self-assemble into spherical nanoparticles in water or in the blood circulation to facilitate their delivery and distribution. When endocytosed into immune cells, BFD can identify and attach to phosphorylation sites on IκBα and in situ transform into a nanofibrous network coating NF-κB/IκBα complexes, blocking the phosphorylation and degradation of IκBα. As a result, BFD enables decreasing expression of proinflammatory mediators. In the present study, we demonstrate that BFD exhibits notable efficacy in alleviating arthritis-related manifestations, such as joints and tissues swelling, as well as bone and cartilage destruction on the collagen-induced arthritis (CIA) rat model. The investigation of intracellular biodistribution, phosphorylation of IκBα, and cytokine detection in culture medium supernatant, joint tissue, and serum exhibits strong associations with therapeutic outcomes. The utilization of transformable peptide presents a novel approach for the management of inflammatory diseases. </div> <a href="javascript:ShowArticleAbstract(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF-%ce%baB%2fI%ce%baB%ce%b1+pathway%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF-κB/IκBα pathway</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phosphorylation+of+I%ce%baB%ce%b1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phosphorylation of IκBα</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rheumatoid+arthritis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rheumatoid arthritis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transformable+peptide%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transformable peptide</a></li></ul> <a href="javascript:ShowArticleKeywords(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF-kappa+B%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF-kappa B/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Rheumatoid%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Rheumatoid/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Rheumatoid%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Rheumatoid/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NF-KappaB+Inhibitor+alpha%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NF-KappaB Inhibitor alpha/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Peptides%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Peptides/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phosphorylation%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phosphorylation/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Experimental%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Experimental/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Experimental%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Experimental/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Experimental%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Experimental/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cytokines%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cytokines/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RAW+264.7+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RAW 264.7 Cells</a></li></ul> <a href="javascript:ShowArticleMeSH(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(24);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow25"> <td style="min-width: 40px; text-align: center;"> 25 </td> <td> <div id="citation25" class="article-citation"> <b>Zhao F</b>, Jia Z, Zhang L, Liu G, Li J, Zhao J, Xie Y, Chen L, Jiang H, He W, Wang A, Peng J, Zheng Y. A MnO<sub>2</sub> nanosheets doping double crosslinked hydrogel for cartilage defect repair through alleviating inflammation and guiding chondrogenic differentiation. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122875. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39454507' target='_blank'>39454507</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122875' target='_blank'>10.1016/j.biomaterials.2024.122875</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122875','39454507', 'Mice')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(25);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(25);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(25);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122875' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/28/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv25" value="10.1016/j.biomaterials.2024.122875" /> <div style="display: none" id="articleAbstract25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The inflammatory microenvironment and inferior chondrogenesis are major symptoms after cartilage defect. Although various modifications strategies associated with hydrogels exhibit remarkable capacity of pro-cartilage regeneration, the adverse effect by prolonging inflammation is still formidable to hamper potential biomedical applications of different hydrogel implants. Herein, inspired by the repair microenvironment of articular cartilage defects, an injectable, immunomodulatory, and chondrogenic L-MNS-CMDA hydrogel is prepared through grafting vinyl and catechol groups to chitosan macromolecules using amide reaction, then further loading MnO2 nanosheets (MNS). The double crosslinking of photopolymerization and catechol oxidative polymerization endows L-MNS-CMDA hydrogel with preferable mechanical property, affording a suitable mechanical support for cartilage defect repair. Additionally, the robust tissue adhesion capability stemming from catechol groups guarantees the long-term retention of the hydrogel in the defect site. Meanwhile, L-MNS-CMDA hydrogel decomposes exogenous and intracellular H2O2 into O2 and H2O, to effectively alleviate cellular oxidative stress caused by long-term hypoxia. Under the synergies of catechol groups and MNS, L-MNS-CMDA hydrogel not only inhibits macrophages polarizing into M1 phenotype, but encourages them turn into M2 phenotype, thereby, reconstructing an immunization friendly microenvironment to ultimately enhance cartilage regeneration. Predictably, the hydrogel markedly induces rat bone marrow mesenchymal stem cells differentiating into chondrocytes by expressing abundant glycosaminoglycan and type II collagen. A cartilage defect model of rat knee joint indicates that L-MNS-CMDA hydrogel visually regulate the early inflammatory response of post-implantation, and facilitate cartilage regeneration and recovery of joint function after 12 weeks of post-implantation. All in all, this multifunctional L-MNS-CMDA hydrogel exhibits superior immunomodulatory and chondrogenic properties, holding immense clinical potential in the treatment of cartilage defects. </div> <a href="javascript:ShowArticleAbstract(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cartilage+defect%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cartilage defect</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chondrogenic+property%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chondrogenic property</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunomodulatory%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunomodulatory</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammatory+microenvironment%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammatory microenvironment</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MnO(2)+nanosheets%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MnO(2) nanosheets</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tissue+adhesion%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tissue adhesion</a></li></ul> <a href="javascript:ShowArticleKeywords(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chondrogenesis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chondrogenesis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Differentiation%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Differentiation/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hydrogels%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hydrogels/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxides%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxides/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammation%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammation/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Manganese+Compounds%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Manganese Compounds/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesenchymal+Stem+Cells%2fcytology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesenchymal Stem Cells/cytology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesenchymal+Stem+Cells%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesenchymal Stem Cells/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesenchymal+Stem+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesenchymal Stem Cells/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Sprague-Dawley%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Sprague-Dawley</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanostructures%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanostructures/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cartilage%2c+Articular%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cartilage, Articular/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cartilage%2c+Articular%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cartilage, Articular/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chondrocytes%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chondrocytes/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chondrocytes%2fcytology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chondrocytes/cytology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cross-Linking+Reagents%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cross-Linking Reagents/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Regeneration%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Regeneration/drug effects</a></li></ul> <a href="javascript:ShowArticleMeSH(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(25);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> </tbody></table> <div id="RootHolder_articleDisplayTip" class="article-display-tip"><span>(The first 100,000 artilces are displayed in RCA.)</span></div> <div class="search-pager-container"> <div class="dxpLite_MetropolisBlue" id="RootHolder_SearchResultPager" style="margin-top: 20px; margin-bottom: 20px;"> <b class="dxp-lead dxp-button dxp-bi dxp-disabledButton"><img class="dxWeb_pPrevDisabled_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Prev" /></b><b class="dxp-summary" style="margin-left:0px;">Page 1 of 4000 </b><b class="dxp-num dxp-current page-number" style="margin-left:0px;">1</b><a class="dxp-num page-number" href="/Search?page=2&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">2</a><a class="dxp-num page-number" href="/Search?page=3&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">3</a><a class="dxp-num page-number" href="/Search?page=4&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">4</a><a class="dxp-num page-number" href="/Search?page=5&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">5</a><b class="dxp-ellip" style="margin-left:0px;">…</b><a class="dxp-num page-number" href="/Search?page=3999&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">3999</a><a class="dxp-num page-number" href="/Search?page=4000&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">4000</a><a class="dxp-button dxp-bi" 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type="text/javascript">  </script> <div id="RootHolder_articleCitationPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:450px;width:600px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam"></span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content">    </div> </div> </div> </div><div id="RootHolder_articleCitationPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_articleCitationPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" 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</table><div id="RootHolder_chartPopupControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_420552910" type="text/javascript">  </script> <div id="RootHolder_pcImportArticlesControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:50px;width:50px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_pcImportArticlesControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Import Articles</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="RootHolder_pcImportArticlesControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcImportArticlesControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcImportArticlesControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcImportArticlesControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_365297802" type="text/javascript">  </script> <div id="RootHolder_pcEditArticleControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_pcEditArticleControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Edit My Journal Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content" style="overflow-x:hidden;overflow-y:scroll;">    </div> </div> </div> </div><div id="RootHolder_pcEditArticleControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcEditArticleControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcEditArticleControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcEditArticleControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_298765222" type="text/javascript">  </script> <div id="RootHolder_userIndexComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:400px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Article Influence Index</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle2">Article Influence Index</span></b> </p> <p> Total Citations in Crossref ÷ Total Articles = <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle3">Article Influence Index</span><sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="RootHolder_userIndexComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_userIndexComputePopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_userIndexComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1286575841" type="text/javascript">  </script> <div id="RootHolder_articleExportPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:280px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow" style="font-size:11pt;"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_articleExportPopup_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Export Articles to File</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="dxtcLite_MetropolisBlue dxtcSys dxtc-init dxtc-top dxtc-pc" id="RootHolder_articleExportPopup_ExportFilePageControl" style="width:100%;"> <ul class="dxtc-strip dxtc-row dxtc-stripContainer"> <li class="dxtc-leftIndent"> </li><li class="dxtc-tab dxtc-lead" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-activeTab dxtc-lead"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-spacer"> </li><li class="dxtc-tab dxtc-last"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-activeTab dxtc-last" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-rightIndent"> </li> </ul><div class="dxtc-content"> <div> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_SearchTermText1">Mice (1134127 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:5px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_1662381219" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailEndIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" value="600" type="text" /></td> </tr> </table><script id="dxss_616434442" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_1167331127" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_54524200" type="text/javascript">  </script><script id="dxss_1678130197" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" style="font-weight:bold;">JCR Year:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" type="hidden" value="2023" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" value="2023" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2023</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2022</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2021</td> </tr> </table> </div></td> </tr> </table><script id="dxss_830317689" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_167955898" type="text/javascript">  </script><script id="dxss_2013408041" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1062639383" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_104403608" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1973673553" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_6" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLTSys dxflItemSys dxflCheckBoxWithTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" style="font-weight:bold;">Record Content:</label></td> </tr><tr> <td class="dxflNestedControlCell_MetropolisBlue"> <table> <tr> <td style="vertical-align: middle; padding: 5px;"> <table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields" style="color:#BD4100;"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$cbSelectAllFields" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label>Select All Fields</label></td> </tr> </table><script id="dxss_1176833720" type="text/javascript">  </script> </td> </tr> <tr> <td style="padding: 5px;"> <table class="dxeCheckBoxList_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields" style="width:100%;border-collapse:separate;"> <tr> <td class="dxe"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields" /><table style="width:100%;"> <tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB0" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Author(s)</label></td> </tr> </table><script id="dxss_771536870" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB1" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Title</label></td> </tr> </table><script id="dxss_1086331335" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB2" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Keywords</label></td> </tr> </table><script id="dxss_1308541020" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB3" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">MESH Headings</label></td> </tr> </table><script id="dxss_896786043" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB4" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Journal Title</label></td> </tr> </table><script id="dxss_450242410" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB5" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Year</label></td> </tr> </table><script id="dxss_765036875" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB6" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Type</label></td> </tr> </table><script id="dxss_1629835480" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB7" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Language</label></td> </tr> </table><script id="dxss_1218080503" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB8" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Published Date</label></td> </tr> </table><script id="dxss_1428514578" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB9" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author</label></td> </tr> </table><script id="dxss_1113720113" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB10" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author’s Affiliations</label></td> </tr> </table><script id="dxss_310841941" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB11" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author</label></td> </tr> </table><script id="dxss_1301541094" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB12" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author’s Affiliations</label></td> </tr> </table><script id="dxss_675718561" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB13" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Email</label></td> </tr> </table><script id="dxss_2006865700" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB14" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">All Authors's Affiliations</label></td> </tr> </table><script id="dxss_1204905793" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB15" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Grant</label></td> </tr> </table><script id="dxss_407477242" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB16" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">ISSN</label></td> </tr> </table><script id="dxss_218345291" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB17" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Publisher</label></td> </tr> </table><script id="dxss_1394037744" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB18" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexing / Abstracting</label></td> </tr> </table><script id="dxss_319681069" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB19" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Factor</label></td> </tr> </table><script id="dxss_1292701966" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB20" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">JCR Quartile</label></td> </tr> </table><script id="dxss_1844280938" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB21" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Index Per Article</label></td> </tr> </table><script id="dxss_838303323" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB22" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Category</label></td> </tr> </table><script id="dxss_1464125856" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB23" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Times Cited in RCA</label></td> </tr> </table><script id="dxss_148257179" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB24" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Peer-Reviewed Journal</label></td> </tr> </table><script id="dxss_950217086" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB25" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Open Access</label></td> </tr> </table><script id="dxss_1732367175" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB26" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">DOI</label></td> </tr> </table><script id="dxss_1936777588" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB27" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">PMID</label></td> </tr> </table><script id="dxss_745806673" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB28" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Citation</label></td> </tr> </table><script id="dxss_1835441810" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB29" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexed in RCA</label></td> </tr> </table><script id="dxss_847142451" type="text/javascript">  </script></td><td></td><td></td> </tr> </table></td> </tr> </table><script id="dxss_1169734383" type="text/javascript">  </script> </td> </tr> </table> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_7" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportedDetailFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_1198171345" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_1960175520" type="text/javascript">  </script> </div> </div><div style="display:none;"> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_SearchTermText2">Mice (1134127 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:10px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_814491935" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportEndSIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" value="600" type="text" /></td> </tr> </table><script id="dxss_1331245653" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:10px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_2046065225" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_1926633208" type="text/javascript">  </script><script id="dxss_228619664" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:20px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" type="hidden" value="1" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" value="Excel" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1509722775" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_960798088" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_835950349" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportedFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_308093146" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_424125632" type="text/javascript">  </script> </div> </div> </div> </div><b class="dx-clear"></b><table id="RootHolder_articleExportPopup_ExportFilePageControl_LP" class="dxtcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_TL">Loading…</span></td> </tr> </table><script id="dxss_2124675053" type="text/javascript">  </script> </div> </div><div class="dxpc-footer"> <div class="popup-footer-button-container"> <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles_I" class="dxb-hb" value="Export" type="submit" name="ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnExportArticles" /><span class="dx-vam">Export</span> </div> </div><script id="dxss_77486387" type="text/javascript">  </script>    <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnCancel" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_articleExportPopup_TPCFm1_btnCancel_I" class="dxb-hb" value="Cancel" type="submit" name="ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnCancel" /><span class="dx-vam">Cancel</span> </div> </div><script id="dxss_2118985763" type="text/javascript">  </script> </div> </div> </div> </div><div id="RootHolder_articleExportPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_articleExportPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="font-size:11pt;left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="font-size:11pt;padding-left:0px;"><span id="RootHolder_articleExportPopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_578446409" type="text/javascript">  </script> </div> <div class="bottom-part cl"> © 2004-2024 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA </div> <div class="scroll"> <a href="#top" target="_self"> <img src="/Contents/Images/backtop3.png" /> </a> </div> <div id="categorySelectorPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Select the Category</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="categorySelectorPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="categorySelectorPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="categorySelectorPopup_TL">Loading…</span></td> </tr> </table><div id="categorySelectorPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_166253781" type="text/javascript">  </script> <div id="pcLoginPopUp_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:700px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="pcLoginPopUp_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="pcLoginPopUp_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="pcLoginPopUp_TL">Loading…</span></td> </tr> </table><div id="pcLoginPopUp_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_430910140" type="text/javascript">  </script> <div id="aiComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:300px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Impact Index Per Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for Impact Index Per Article</b> </p> <p> Times Cited ÷ Number of Years = Impact Index Per Article<sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="aiComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="aiComputePopup_TL">Loading…</span></td> </tr> </table><div id="aiComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_698179129" type="text/javascript">  </script> <script type="text/javascript"> //<![CDATA[ var callBackFrameUrl='/WebResource.axd?d=beToSAE3vdsL1QUQUxjWdX-3aFLejnBliGvqSCZYULGFdxZmRlcJcqs71AKVNTQEXljNmd0slFkUZ_AFaCke4Q2&t=638628207619783110'; WebForm_InitCallback();//]]> </script> </form> </body> </html>