The Tyrosinase and Cyclooxygenase Inhibitory Activities and Cytotoxicity Screening of Tamarindus indica Seeds

<!DOCTYPE html> <html lang="en" dir="ltr"> <head>  <script async src="https://www.googletagmanager.com/gtag/js?id=G-P63WKM1TM1"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-P63WKM1TM1'); </script>  <script type="text/javascript" > (function(m,e,t,r,i,k,a){m[i]=m[i]||function(){(m[i].a=m[i].a||[]).push(arguments)}; m[i].l=1*new Date(); for (var j = 0; j < document.scripts.length; j++) {if (document.scripts[j].src === r) { return; }} k=e.createElement(t),a=e.getElementsByTagName(t)[0],k.async=1,k.src=r,a.parentNode.insertBefore(k,a)}) (window, document, "script", "https://mc.yandex.ru/metrika/tag.js", "ym"); ym(55165297, "init", { clickmap:false, trackLinks:true, accurateTrackBounce:true, webvisor:false }); </script> <noscript><div><img src="https://mc.yandex.ru/watch/55165297" style="position:absolute; left:-9999px;" alt="" /></div></noscript>    <title>The Tyrosinase and Cyclooxygenase Inhibitory Activities and Cytotoxicity Screening of Tamarindus indica Seeds</title> <meta name="description" content="The Tyrosinase and Cyclooxygenase Inhibitory Activities and Cytotoxicity Screening of Tamarindus indica Seeds"> <meta name="keywords" content="Tamarindus indica, anti-melanogenic, antiinflammatotion, cytotoxicity, seed, phenolic compounds."> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <meta name="citation_title" content="The Tyrosinase and Cyclooxygenase Inhibitory Activities and Cytotoxicity Screening of Tamarindus indica Seeds"> <meta name="citation_author" content="P. Thongmuang"> <meta name="citation_author" content="Y. Sudjaroen"> <meta name="citation_publication_date" content="2013/01/24"> <meta name="citation_journal_title" content="International Journal of Agricultural and Biosystems Engineering"> <meta name="citation_volume" content="7"> <meta name="citation_issue" content="1"> <meta name="citation_firstpage" content="11"> <meta name="citation_lastpage" content="13"> <meta name="citation_pdf_url" content="https://publications.waset.org/2655/pdf"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" type="button" data-toggle="collapse" data-target="#navbarMenu" aria-controls="navbarMenu" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button> <div class="w-100"> <div class="d-none d-lg-flex flex-row-reverse"> <form method="get" action="https://waset.org/search" class="form-inline my-2 my-lg-0"> <input class="form-control mr-sm-2" type="search" placeholder="Search Conferences" value="" name="q" aria-label="Search"> <button class="btn btn-light my-2 my-sm-0" type="submit"><i class="fas fa-search"></i></button> </form> </div> <div class="collapse navbar-collapse mt-1" id="navbarMenu"> <ul class="navbar-nav ml-auto align-items-center" id="mainNavMenu"> <li class="nav-item"> <a class="nav-link" href="https://waset.org/conferences" title="Conferences in 2024/2025/2026">Conferences</a> </li> <li class="nav-item"> <a class="nav-link" href="https://waset.org/disciplines" title="Disciplines">Disciplines</a> </li> <li class="nav-item"> <a class="nav-link" href="https://waset.org/committees" rel="nofollow">Committees</a> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdownPublications" role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> Publications </a> <div class="dropdown-menu" aria-labelledby="navbarDropdownPublications"> <a class="dropdown-item" href="https://publications.waset.org/abstracts">Abstracts</a> <a class="dropdown-item" href="https://publications.waset.org">Periodicals</a> <a class="dropdown-item" href="https://publications.waset.org/archive">Archive</a> </div> </li> <li class="nav-item"> <a class="nav-link" href="https://waset.org/page/support" title="Support">Support</a> </li> </ul> </div> </div> </nav> </div> </header> <main> <div class="container mt-4"> <div class="row"> <div class="col-md-9 mx-auto"> <form method="get" action="https://publications.waset.org/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value=""> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 33093</div> </div> </div> </div> <div class="card publication-listing mt-3 mb-3"> <h5 class="card-header" style="font-size:.9rem">The Tyrosinase and Cyclooxygenase Inhibitory Activities and Cytotoxicity Screening of Tamarindus indica Seeds</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=P.%20Thongmuang">P. Thongmuang</a>, <a href="https://publications.waset.org/search?q=Y.%20Sudjaroen"> Y. Sudjaroen</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The methanolic extracts from seeds of tamarind (Tamarindus indica) was prepared by Soxhlet apparatus extraction and evaluated for total phenolic content by Folin-Ciocalteu method. Then, methanolic extract was screened biological activities (In vitro) for anti-melanogenic activity by tyrosinase inhibition test, antiinflammation activity by cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2) inhibition test, and cytotoxic screening test with Vero cells. The results showed that total phenolic content, which contained in extract, was contained 27.72 mg of gallic acid equivalent per g of dry weight. The ability to inhibit tyrosinase enzyme, which exerted by Tamarind seed extracts (1 mg/ml) was 52.13 卤 0.42 %. The extract was not possessed inhibitory effect to COX-1 and COX-2 enzymes and cytotoxic effect to Vero cells. The finding is concludes that tested seed extract was possessed antimelanogenic activity with non-toxic effects. However, there was not exhibited anti-inflammatory activity. Further studies include the use of advance biological models to confirm this biological activity, as well as, the isolation and characterization of the purified compounds that it was contained. <iframe src="https://publications.waset.org/2655.pdf" style="width:100%; height:400px;" frameborder="0"></iframe> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Tamarindus%20indica" title="Tamarindus indica">Tamarindus indica</a>, <a href="https://publications.waset.org/search?q=anti-melanogenic" title=" anti-melanogenic"> anti-melanogenic</a>, <a href="https://publications.waset.org/search?q=antiinflammatotion" title=" antiinflammatotion"> antiinflammatotion</a>, <a href="https://publications.waset.org/search?q=cytotoxicity" title=" cytotoxicity"> cytotoxicity</a>, <a href="https://publications.waset.org/search?q=seed" title=" seed"> seed</a>, <a href="https://publications.waset.org/search?q=phenolic%20compounds." title=" phenolic compounds."> phenolic compounds.</a> </p> <p class="card-text"><strong>Digital Object Identifier (DOI):</strong> <a href="https://doi.org/10.5281/zenodo.1057645" target="_blank">doi.org/10.5281/zenodo.1057645</a> </p> <a href="https://publications.waset.org/2655/the-tyrosinase-and-cyclooxygenase-inhibitory-activities-and-cytotoxicity-screening-of-tamarindus-indica-seeds" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/2655/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/2655/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/2655/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/2655/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/2655/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/2655/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/2655/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/2655/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/2655/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/2655/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/2655.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">2941</span> </span> <p class="card-text"><strong>References:</strong></p> <br>[1] S. Briganti, E. Camera, and M. Picado, "Chemical and instrumental approachs to treat hyperpigmentation," Pigment Cell Res, vol. 16, 2003, pp. 101-110. <br>[2] D. Jang, B. Lee, C. Jeon et al, "Melanogenesis inhibitor form Paper Mulberry," Cosmetics & Toiletries Magazine, vol. 112, 1997, pp. 59-62. <br>[3] O. Lee, H. Kang and S. Han, "Oriental herbs in cosmetics," Cosmetics & Toiletries Magazine, vol. 112, Jan. 1997, pp. 57-64. <br>[4] T. Piamphongsant, "Problems in developing cosmetic in dustry," in Conf. 2003 Aug, 14 The development of cosmetic industry for selfreliance" organized by the office of the National Research Council of Thailand,. <br>[5] P. L. Olliaro and Y. Yuthavong, "An overview of chemotherapeutic targets for antimalarial drug discovery," Pharmacol Ther, vol. 81, 1999, pp. 91-110. <br>[6] T, Phakruschaphan, "Comparison of peeling and extraction methods in the production of Tamarind seed gum," The Kasetsart Journal of Natural Sciences, vol. 16, 1982, pp. 74-81. <br>[7] T. Tsuda, M. Watanabe, K. Ohshima, A. Yamamoto, S. Kawakishi and T. Osawa, "Antioxidative components isolated from the seed of Tamarind (Tamarindus indica L.)," Journal Agricultural and Food Chemistry, vol. 42, 1994, pp. 2671-2674. <br>[8] T. Tsuda, T. Osawa, Y. Makino, H. Kato and S. Kawakishi, "Screening for antioxidant activity of edible pulses," Bioscientific Biotechnological Biochemistry, vol. 57, 1993, pp. 1606-1608. <br>[9] M. De, A. Krishna and A.B. Baneerjee , "Antimicrobial screening of some Indian spices," Phytotherapy Research, vol. 13, 1999, pp. 616- 618. <br>[10] Y. Sudjaroen, R. Haubner, G. Wurtele, W.E. Hull, G. Erben, B. Spiegelhalder, S. Changbumrung, H. Bartsch and R.W. Owen, "Isolation and structure elucidation of phenolic antioxidants from Tamarind (Tamarindus indica L.) seeds and pericarp," Food and Chemical Toxicology, vol. 43, 2005, pp. 1673-1682. <br>[11] V.L. Singleton, R. Orthofer and R.M. Lamuela-Ravent鈹溾攤s, "Analysis of Total Phenols and Other Oxidation Substrates and Antioxidants by Means of Folin-ciocalteu Reagent," Methods in Enzymology, vol. 299, 1999, pp. 152-178. <br>[12] V. J. Hearing and K. Tsukamoto, "Enzymatic control of pigmentation in mammals," FASEB J., vol. 5, Nov. 1991, pp. 2902脭脟枚2909. <br>[13] Y.J. Kim, "Antimelanogenic and antioxidant properties of gallic acid," Biol. Pharm. Bull. vol. 30, Jun. 2007, pp. 1052脭脟枚1055. <br>[14] K. Kirtikara, S.G. Morham, R. Raghow, S.J.F. Laulederkind, T. Kanekura, S. Goorha and L.R. Ballou, "Compensatory protaglandin E2 biosynthesis in cyclooxygenase1 or 2 null cells," J Exp Med, vol. 187, 1998, pp. 517-23. <br>[15] K. Kirtikara, S. Swangkul and L.R. Ballou, "The analysis of nonsteroidal anti-inflammatory drug selectivity in prostaglandin G/H synthase (PGHS)-null cells," Inflamm Res, vol. 50, 2001, pp. 327-32. <br>[16] P. Skehan, R. Storeng, D. Scudiero, et al, "New colorimetric cytotoxicity assay for anticancer-drug screening," J Natl Cancer Inst, vol. 82, 1990, pp. 1107-12. <br>[17] M. Naczk and F. Shahidi, "Phenolics in cereals, fruits and vegetables: occurrence, extraction and analysis," J Pharm Biomed Anal, vol. 41, Jan. 2006, pp. 1523-1542. <br>[18] H-J. Yoon and S.J. Baek, "Molecular targets of dietary polyphenols with anti-inflammatory properties," Yonsei Med J, vol. 46, 2005, pp. 585-596. </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational anniversary</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Account <li><a href="https://waset.org/profile">My Account</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Explore <li><a href="https://waset.org/disciplines">Disciplines</a></li> <li><a href="https://waset.org/conferences">Conferences</a></li> <li><a href="https://waset.org/conference-programs">Conference Program</a></li> <li><a href="https://waset.org/committees">Committees</a></li> <li><a href="https://publications.waset.org">Publications</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Research <li><a href="https://publications.waset.org/abstracts">Abstracts</a></li> <li><a href="https://publications.waset.org">Periodicals</a></li> <li><a href="https://publications.waset.org/archive">Archive</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Open Science <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Philosophy.pdf">Open Science Philosophy</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Award.pdf">Open Science Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Society-Open-Science-and-Open-Innovation.pdf">Open Innovation</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Postdoctoral-Fellowship-Award.pdf">Postdoctoral Fellowship Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Scholarly-Research-Review.pdf">Scholarly Research Review</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Support <li><a href="https://waset.org/page/support">Support</a></li> <li><a href="https://waset.org/profile/messages/create">Contact Us</a></li> <li><a href="https://waset.org/profile/messages/create">Report Abuse</a></li> </ul> </div> </div> </div> </div> </div> <div class="container text-center"> <hr style="margin-top:0;margin-bottom:.3rem;"> <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" class="text-muted small">Creative Commons Attribution 4.0 International License</a> <div id="copy" class="mt-2">© 2024 World Academy of Science, Engineering and Technology</div> </div> </footer> <a href="javascript:" id="return-to-top"><i class="fas fa-arrow-up"></i></a> <div class="modal" id="modal-template"> <div class="modal-dialog"> <div class="modal-content"> <div class="row m-0 mt-1"> <div class="col-md-12"> <button type="button" class="close" data-dismiss="modal" aria-label="Close"><span aria-hidden="true">×</span></button> </div> </div> <div class="modal-body"></div> </div> </div> </div> <script src="https://cdn.waset.org/static/plugins/jquery-3.3.1.min.js"></script> <script src="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/js/bootstrap.bundle.min.js"></script> <script src="https://cdn.waset.org/static/js/site.js?v=150220211556"></script> <script> jQuery(document).ready(function() { /*jQuery.get("https://publications.waset.org/xhr/user-menu", function (response) { jQuery('#mainNavMenu').append(response); });*/ jQuery.get({ url: "https://publications.waset.org/xhr/user-menu", cache: false }).then(function(response){ jQuery('#mainNavMenu').append(response); }); }); </script> </body> </html>

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The Tyrosinase and Cyclooxygenase Inhibitory Activities and Cytotoxicity Screening of Tamarindus indica Seeds