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class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Inmunoglobulina_antitet%C3%A1nica" title="Inmunoglobulina antitetánica – Spanish" lang="es" hreflang="es" data-title="Inmunoglobulina antitetánica" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Immunoglobuline_antit%C3%A9tanique" title="Immunoglobuline antitétanique – French" lang="fr" hreflang="fr" data-title="Immunoglobuline antitétanique" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-hy mw-list-item"><a href="https://hy.wikipedia.org/wiki/%D5%80%D5%A1%D5%AF%D5%A1%D6%83%D5%A1%D5%B5%D5%BF%D5%A1%D6%81%D5%B4%D5%A1%D5%B6_%D5%AB%D5%B4%D5%B8%D6%82%D5%B6%D5%B8%D5%A3%D5%AC%D5%B8%D5%A2%D5%B8%D6%82%D5%AC%D5%AB%D5%B6" title="Հակափայտացման իմունոգլոբուլին – Armenian" lang="hy" hreflang="hy" data-title="Հակափայտացման իմունոգլոբուլին" data-language-autonym="Հայերեն" data-language-local-name="Armenian" class="interlanguage-link-target"><span>Հայերեն</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Imunoglobulin_anti-tetanus" title="Imunoglobulin anti-tetanus – Indonesian" lang="id" hreflang="id" data-title="Imunoglobulin anti-tetanus" data-language-autonym="Bahasa Indonesia" data-language-local-name="Indonesian" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E6%8A%97%E7%A0%B4%E5%82%B7%E9%A2%A8%E5%85%8D%E7%96%AB%E3%82%B0%E3%83%AD%E3%83%96%E3%83%AA%E3%83%B3" title="抗破傷風免疫グロブリン – Japanese" lang="ja" hreflang="ja" data-title="抗破傷風免疫グロブリン" data-language-autonym="日本語" data-language-local-name="Japanese" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-or mw-list-item"><a href="https://or.wikipedia.org/wiki/%E0%AC%86%E0%AC%A3%E0%AD%8D%E0%AC%9F%E0%AC%BF%E0%AC%9F%E0%AD%87%E0%AC%9F%E0%AC%BE%E0%AC%A8%E0%AC%B8_%E0%AC%87%E0%AC%AE%E0%AD%8D%E0%AC%AE%E0%AD%8D%E0%AD%9F%E0%AD%81%E0%AC%A8%E0%AD%8B%E0%AC%97%E0%AD%8D%E0%AC%B2%E0%AD%8B%E0%AC%AC%E0%AD%8D%E0%AD%9F%E0%AD%81%E0%AC%B2%E0%AC%BF%E0%AC%A8" title="ଆଣ୍ଟିଟେଟାନସ ଇମ୍ମ୍ୟୁନୋଗ୍ଲୋବ୍ୟୁଲିନ – Odia" lang="or" hreflang="or" data-title="ଆଣ୍ଟିଟେଟାନସ ଇମ୍ମ୍ୟୁନୋଗ୍ଲୋବ୍ୟୁଲିନ" data-language-autonym="ଓଡ଼ିଆ" data-language-local-name="Odia" class="interlanguage-link-target"><span>ଓଡ଼ିଆ</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Imunoglobulina_antitet%C3%A2nica" title="Imunoglobulina antitetânica – Portuguese" lang="pt" hreflang="pt" data-title="Imunoglobulina antitetânica" data-language-autonym="Português" data-language-local-name="Portuguese" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Stelkrampsantitoxin" title="Stelkrampsantitoxin – Swedish" lang="sv" hreflang="sv" data-title="Stelkrampsantitoxin" data-language-autonym="Svenska" data-language-local-name="Swedish" class="interlanguage-link-target"><span>Svenska</span></a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/Globulin_mi%E1%BB%85n_d%E1%BB%8Bch_u%E1%BB%91n_v%C3%A1n" title="Globulin miễn dịch uốn ván – Vietnamese" lang="vi" hreflang="vi" data-title="Globulin miễn dịch uốn ván" data-language-autonym="Tiếng Việt" 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.infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox" style="border-spacing:2px;"><caption class="infobox-title"><span title="International nonproprietary name (INN): Anti-tetanus immunoglobulin">Anti-tetanus immunoglobulin</span></caption><tbody><tr><td colspan="2" class="infobox-image notheme" style="background-color: #f8f9fa;"><span class="mw-default-size" typeof="mw:File/Frameless"><a href="/wiki/File:Bottle_of_tetanus_antitoxin,_Germany._Full_view,_graduated_g_Wellcome_L0058962_(cropped).jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/8/8f/Bottle_of_tetanus_antitoxin%2C_Germany._Full_view%2C_graduated_g_Wellcome_L0058962_%28cropped%29.jpg/220px-Bottle_of_tetanus_antitoxin%2C_Germany._Full_view%2C_graduated_g_Wellcome_L0058962_%28cropped%29.jpg" decoding="async" width="220" height="301" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/8f/Bottle_of_tetanus_antitoxin%2C_Germany._Full_view%2C_graduated_g_Wellcome_L0058962_%28cropped%29.jpg/330px-Bottle_of_tetanus_antitoxin%2C_Germany._Full_view%2C_graduated_g_Wellcome_L0058962_%28cropped%29.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/8f/Bottle_of_tetanus_antitoxin%2C_Germany._Full_view%2C_graduated_g_Wellcome_L0058962_%28cropped%29.jpg/440px-Bottle_of_tetanus_antitoxin%2C_Germany._Full_view%2C_graduated_g_Wellcome_L0058962_%28cropped%29.jpg 2x" data-file-width="2856" data-file-height="3912" /></a></span><div class="infobox-caption">A vintage single-dose bottle of tetanus antitoxin manufactured by Sächsisches Serumwerk Dresden (now <a href="/wiki/GlaxoSmithKline" class="mw-redirect" title="GlaxoSmithKline">GlaxoSmithKline</a>)</div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Clinical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Drug_nomenclature#Trade_names" title="Drug nomenclature">Trade names</a></th><td class="infobox-data">HyperTET S/D, others</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;">Other names</th><td class="infobox-data">tetanus immune globulin, tetanus antitoxin</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/American_Society_of_Health-System_Pharmacists" title="American Society of Health-System Pharmacists">AHFS</a>/<a href="/wiki/Drugs.com" title="Drugs.com">Drugs.com</a></th><td class="infobox-data"><span title="www.drugs.com"><a rel="nofollow" class="external text" href="https://www.drugs.com/monograph/tetanus-immune-globulin.html">Monograph</a></span></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Route_of_administration" title="Route of administration">Routes of<br />administration</a></th><td class="infobox-data">IM</td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CAS_Registry_Number" title="CAS Registry Number">CAS Number</a></th><td class="infobox-data"><style data-mw-deduplicate="TemplateStyles:r1126788409">.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}</style><div class="plainlist"><ul><li><span title="commonchemistry.cas.org"><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=1698057-17-8">1698057-17-8</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChemSpider" title="ChemSpider">ChemSpider</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li>none</li></ul></div></td></tr></tbody></table> <p><b>Anti-tetanus immunoglobulin</b>, also known as <b>tetanus immune globulin</b> (<b>TIG</b>) and <b>tetanus antitoxin</b>, is a medication made up of <a href="/wiki/Antibodies" class="mw-redirect" title="Antibodies">antibodies</a> against the <a href="/wiki/Tetanus_toxin" title="Tetanus toxin">tetanus toxin</a>.<sup id="cite_ref-AHFS2017_1-0" class="reference"><a href="#cite_note-AHFS2017-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> It is used to prevent <a href="/wiki/Tetanus" title="Tetanus">tetanus</a> in those who have a wound that is at high risk, have not been fully <a href="/wiki/Vaccinated" class="mw-redirect" title="Vaccinated">vaccinated</a> with <a href="/wiki/Tetanus_toxoid" class="mw-redirect" title="Tetanus toxoid">tetanus toxoid</a>, or have <a href="/wiki/HIV/AIDS" title="HIV/AIDS">HIV/AIDS</a>.<sup id="cite_ref-AHFS2017_1-1" class="reference"><a href="#cite_note-AHFS2017-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:0_2-0" class="reference"><a href="#cite_note-:0-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> It is used to treat tetanus along with <a href="/wiki/Antibiotics" class="mw-redirect" title="Antibiotics">antibiotics</a> and <a href="/wiki/Muscle_relaxants" class="mw-redirect" title="Muscle relaxants">muscle relaxants</a>.<sup id="cite_ref-AHFS2017_1-2" class="reference"><a href="#cite_note-AHFS2017-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> It is given by <a href="/wiki/Intramuscular" class="mw-redirect" title="Intramuscular">injection into a muscle</a>.<sup id="cite_ref-AHFS2017_1-3" class="reference"><a href="#cite_note-AHFS2017-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> Part of the dose is injected at the site of the wound.<sup id="cite_ref-:0_2-1" class="reference"><a href="#cite_note-:0-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> </p><p>Common side effects include pain at the site of injection and fever.<sup id="cite_ref-AHFS2017_1-4" class="reference"><a href="#cite_note-AHFS2017-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Allergic_reactions" class="mw-redirect" title="Allergic reactions">Allergic reactions</a> including <a href="/wiki/Anaphylaxis" title="Anaphylaxis">anaphylaxis</a> may rarely occur.<sup id="cite_ref-AHFS2017_1-5" class="reference"><a href="#cite_note-AHFS2017-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> There is also a very low risk of the spread of infections such as <a href="/wiki/Viral_hepatitis" title="Viral hepatitis">viral hepatitis</a> and <a href="/wiki/HIV/AIDS" title="HIV/AIDS">HIV/AIDS</a> with the human version.<sup id="cite_ref-AHFS2017_1-6" class="reference"><a href="#cite_note-AHFS2017-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> Use during <a href="/wiki/Pregnancy" title="Pregnancy">pregnancy</a> and <a href="/wiki/Lactation" title="Lactation">lactation</a> is acceptable.<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:1_4-0" class="reference"><a href="#cite_note-:1-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> It is made from either human or horse <a href="/wiki/Blood_plasma" title="Blood plasma">blood plasma</a>.<sup id="cite_ref-AHFS2017_1-7" class="reference"><a href="#cite_note-AHFS2017-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-IE2016_5-0" class="reference"><a href="#cite_note-IE2016-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p><p>The immunoglobulin is categorized as <a href="/wiki/Immunoglobulin_G" title="Immunoglobulin G">immunoglobulin G</a> (IgG).<sup id="cite_ref-:1_4-1" class="reference"><a href="#cite_note-:1-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> Since the tetanus toxin permanently binds to human tissues, only unbounded molecules can be neutralized by the immunoglobulin.<sup id="cite_ref-:0_2-2" class="reference"><a href="#cite_note-:0-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> </p><p>Use of the horse version became common in the 1910s, while the human version came into frequent use in the 1960s.<sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> It is on the <a href="/wiki/WHO_Model_List_of_Essential_Medicines" title="WHO Model List of Essential Medicines">World Health Organization's List of Essential Medicines</a>.<sup id="cite_ref-WHO21st_7-0" class="reference"><a href="#cite_note-WHO21st-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-WHO22nd_8-0" class="reference"><a href="#cite_note-WHO22nd-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> The human version may be unavailable in the developing world.<sup id="cite_ref-IE2016_5-1" class="reference"><a href="#cite_note-IE2016-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> The horse version is not typically used in the <a href="/wiki/Developed_world" class="mw-redirect" title="Developed world">developed world</a> due to the risk of <a href="/wiki/Serum_sickness" title="Serum sickness">serum sickness</a>.<sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Anti-tetanus_immunoglobulin&action=edit&section=1" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-AHFS2017-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-AHFS2017_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-AHFS2017_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-AHFS2017_1-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-AHFS2017_1-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-AHFS2017_1-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-AHFS2017_1-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-AHFS2017_1-6"><sup><i><b>g</b></i></sup></a> <a href="#cite_ref-AHFS2017_1-7"><sup><i><b>h</b></i></sup></a></span> <span class="reference-text"><style 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no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output 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License: CC BY-NC-SA 3.0 IGO.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=World+Health+Organization+model+list+of+essential+medicines%3A+21st+list+2019&rft.place=Geneva&rft.pub=World+Health+Organization&rft.date=2019&rft_id=info%3Ahdl%2F10665%2F325771&rft.au=World+Health+Organization&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAnti-tetanus+immunoglobulin" class="Z3988"></span></span> </li> <li id="cite_note-WHO22nd-8"><span class="mw-cite-backlink"><b><a href="#cite_ref-WHO22nd_8-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWorld_Health_Organization2021" class="citation book cs1"><a href="/wiki/World_Health_Organization" title="World Health Organization">World Health Organization</a> (2021). <i>World Health Organization model list of essential medicines: 22nd list (2021)</i>. 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McGraw Hill Professional. p. 773. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/9780071641142" title="Special:BookSources/9780071641142"><bdi>9780071641142</bdi></a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20170109113127/https://books.google.ca/books?id=_YqKAwAAQBAJ&q">Archived</a> from the original on 2017-01-09.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Harrison%27s+Principles+of+Internal+Medicine%2C+17th+Edition&rft.pages=773&rft.pub=McGraw+Hill+Professional&rft.date=2008&rft.isbn=9780071641142&rft.aulast=Fauci&rft.aufirst=AS&rft.au=Braunwald%2C+E&rft.au=Kasper%2C+DL&rft.au=Hauser%2C+S&rft.au=Longo%2C+D&rft.au=Jameson%2C+JL&rft.au=Loscalzo%2C+J&rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3D_YqKAwAAQBAJ&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAnti-tetanus+immunoglobulin" class="Z3988"></span></span> </li> </ol></div></div> <style data-mw-deduplicate="TemplateStyles:r1130092004">.mw-parser-output .portal-bar{font-size:88%;font-weight:bold;display:flex;justify-content:center;align-items:baseline}.mw-parser-output .portal-bar-bordered{padding:0 2em;background-color:#fdfdfd;border:1px solid #a2a9b1;clear:both;margin:1em auto 0}.mw-parser-output .portal-bar-related{font-size:100%;justify-content:flex-start}.mw-parser-output .portal-bar-unbordered{padding:0 1.7em;margin-left:0}.mw-parser-output .portal-bar-header{margin:0 1em 0 0.5em;flex:0 0 auto;min-height:24px}.mw-parser-output .portal-bar-content{display:flex;flex-flow:row wrap;flex:0 1 auto;padding:0.15em 0;column-gap:1em;align-items:baseline;margin:0;list-style:none}.mw-parser-output .portal-bar-content-related{margin:0;list-style:none}.mw-parser-output .portal-bar-item{display:inline-block;margin:0.15em 0.2em;min-height:24px;line-height:24px}@media screen and (max-width:768px){.mw-parser-output .portal-bar{font-size:88%;font-weight:bold;display:flex;flex-flow:column wrap;align-items:baseline}.mw-parser-output .portal-bar-header{text-align:center;flex:0;padding-left:0.5em;margin:0 auto}.mw-parser-output .portal-bar-related{font-size:100%;align-items:flex-start}.mw-parser-output .portal-bar-content{display:flex;flex-flow:row wrap;align-items:center;flex:0;column-gap:1em;border-top:1px solid #a2a9b1;margin:0 auto;list-style:none}.mw-parser-output .portal-bar-content-related{border-top:none;margin:0;list-style:none}}.mw-parser-output .navbox+link+.portal-bar,.mw-parser-output .navbox+style+.portal-bar,.mw-parser-output .navbox+link+.portal-bar-bordered,.mw-parser-output .navbox+style+.portal-bar-bordered,.mw-parser-output .sister-bar+link+.portal-bar,.mw-parser-output .sister-bar+style+.portal-bar,.mw-parser-output .portal-bar+.navbox-styles+.navbox,.mw-parser-output .portal-bar+.navbox-styles+.sister-bar{margin-top:-1px}</style><div class="portal-bar noprint metadata noviewer portal-bar-bordered" role="navigation" aria-label="Portals"><span class="portal-bar-header"><a href="/wiki/Wikipedia:Contents/Portals" title="Wikipedia:Contents/Portals">Portal</a>:</span><ul class="portal-bar-content"><li class="portal-bar-item"><span class="nowrap"><span typeof="mw:File"><span><img alt="icon" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/WHO_Rod.svg/8px-WHO_Rod.svg.png" decoding="async" width="8" height="19" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/WHO_Rod.svg/12px-WHO_Rod.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d6/WHO_Rod.svg/16px-WHO_Rod.svg.png 2x" data-file-width="107" data-file-height="250" /></span></span> </span><a href="/wiki/Portal:Medicine" title="Portal:Medicine">Medicine</a></li></ul></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; 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