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href="https://de.wikipedia.org/wiki/Piebaldismus" title="Piebaldismus – German" lang="de" hreflang="de" data-title="Piebaldismus" data-language-autonym="Deutsch" data-language-local-name="German" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Piebaldismo" title="Piebaldismo – Spanish" lang="es" hreflang="es" data-title="Piebaldismo" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D9%BE%DB%8C%D8%B3%D9%87%E2%80%8C%DA%AF%D8%B1%D8%A7%DB%8C%DB%8C" title="پیسه‌گرایی – Persian" lang="fa" hreflang="fa" data-title="پیسه‌گرایی" data-language-autonym="فارسی" data-language-local-name="Persian" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Pi%C3%A9baldisme" title="Piébaldisme – French" lang="fr" hreflang="fr" data-title="Piébaldisme" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Piebaldismo" title="Piebaldismo – Italian" lang="it" hreflang="it" data-title="Piebaldismo" data-language-autonym="Italiano" data-language-local-name="Italian" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-lt mw-list-item"><a href="https://lt.wikipedia.org/wiki/%C5%BDmoni%C5%B3_piebaldizmas" title="Žmonių piebaldizmas – Lithuanian" lang="lt" hreflang="lt" data-title="Žmonių piebaldizmas" data-language-autonym="Lietuvių" data-language-local-name="Lithuanian" class="interlanguage-link-target"><span>Lietuvių</span></a></li><li class="interlanguage-link interwiki-pl 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.infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox ib-medical-condition"><tbody><tr><th colspan="2" class="infobox-above" style="background:#ccc">Piebaldism</th></tr><tr><th scope="row" class="infobox-label">Other names</th><td class="infobox-data">PBT<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></td></tr><tr style="background-color: #f8f9fa;"><td colspan="2" class="infobox-full-data"><span class="mw-default-size" typeof="mw:File/Frameless"><a href="/wiki/File:Illu_skin02.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/d/dd/Illu_skin02.jpg/220px-Illu_skin02.jpg" decoding="async" width="220" height="167" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/dd/Illu_skin02.jpg/330px-Illu_skin02.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/d/dd/Illu_skin02.jpg 2x" data-file-width="397" data-file-height="302" /></a></span></td></tr><tr><td colspan="2" class="infobox-full-data">This condition affects melanocyte development</td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Medical_specialty" title="Medical specialty">Specialty</a></th><td class="infobox-data"><a href="/wiki/Dermatology" title="Dermatology">Dermatology</a></td></tr></tbody></table> <p><b>Piebaldism</b> refers to the absence of mature melanin-forming cells (melanocytes) in certain areas of the skin and hair. It is a rare <a href="/wiki/Mendelian_inheritance" title="Mendelian inheritance">autosomal dominant</a> disorder of <a href="/wiki/Melanocyte" title="Melanocyte">melanocyte</a> development.<sup id="cite_ref-Andrews_2-0" class="reference"><a href="#cite_note-Andrews-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup class="reference nowrap"><span title="Page / location: 867">: 867 </span></sup> Common characteristics include a congenital white <a href="/wiki/Forelock" title="Forelock">forelock</a>, scattered normal pigmented and hypopigmented <a href="/wiki/Macule" class="mw-redirect" title="Macule">macules</a> and a triangular shaped depigmented patch on the forehead. There is nevertheless great variation in the degree and pattern of presentation, even within affected families. In some cases, piebaldism occurs together with severe developmental problems, as in <a href="/wiki/Waardenburg_syndrome" title="Waardenburg syndrome">Waardenburg syndrome</a> and <a href="/wiki/Hirschsprung%27s_disease" title="Hirschsprung's disease">Hirschsprung's disease</a>. </p><p>Piebaldism has been documented to occur in all races, and is found in nearly every species of mammal. The condition is very common in mice, rabbits, dogs, sheep, deer, cattle and horses—where selective breeding has increased the incidence of the mutation—but occurs among chimpanzees and other primates only as rarely as among humans. Piebaldism is unrelated to conditions such as <a href="/wiki/Vitiligo" title="Vitiligo">vitiligo</a> or <a href="/wiki/Poliosis" title="Poliosis">poliosis</a>. </p><p>Although "partial albinism" is a synonym for piebaldism,<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> it is a fundamentally different condition from true <a href="/wiki/Albinism" title="Albinism">albinism</a>. The vision problems associated with albinism are not usually present as eye pigmentation is normal. Piebaldism differs from albinism in that the affected cells maintain the ability to produce pigment but have that specific function turned off. In albinism the cells lack the ability to produce pigment altogether. Human piebaldism has been observed to be associated with a very wide range and varying degrees of endocrine disorders, and is occasionally found together with heterochromia of the irises, congenital deafness, or incomplete gastrointestinal tract development, possibly all with the common cause of premature cutting off of human fetal growth hormone during gestation. Piebaldism is a kind of <a href="/wiki/Neurocristopathy" title="Neurocristopathy">neurocristopathy</a>, involving defects of various neural crest cell lineages that include melanocytes, but also involving many other tissues derived from the neural crest. Oncogenic factors, including mistranscription, are hypothesized to be related to the degree of phenotypic variation among affected individuals. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Genetics">Genetics</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Piebaldism&action=edit&section=1" title="Edit section: Genetics"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Piebaldism is an autosomal dominant<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> hereditary condition, which tends to produce high rates of inheritance and long chains of generational transmission. All who inherit the gene have at some time in life evidence of piebald hypopigmentation of the hair or skin, most likely both.<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (September 2021)">citation needed</span></a></i>]</sup> </p><p>Piebaldism may be associated with the genes <i><a href="/wiki/KIT_(gene)" title="KIT (gene)">KIT</a></i><sup id="cite_ref-pmid1717985_5-0" class="reference"><a href="#cite_note-pmid1717985-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> or <i><a href="/wiki/SNAI2" title="SNAI2">SNAI2</a></i>.<sup id="cite_ref-pmid12955764_6-0" class="reference"><a href="#cite_note-pmid12955764-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Diagnosis">Diagnosis</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Piebaldism&action=edit&section=2" title="Edit section: Diagnosis"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Usually diagnosed at birth with the appearance of patches of white skin on the arms, legs, stomach, forehead, and a white lock of hair.<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (November 2024)">citation needed</span></a></i>]</sup> </p> <div class="mw-heading mw-heading2"><h2 id="History">History</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Piebaldism&action=edit&section=3" title="Edit section: History"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Early photographers took many photographs of <a href="/wiki/African_people" class="mw-redirect" title="African people">African people</a> with piebaldism as a form of entertainment and exoticism, and <a href="/wiki/George_Catlin" title="George Catlin">George Catlin</a> is believed to have painted several portraits of <a href="/wiki/Native_Americans_in_the_United_States" title="Native Americans in the United States">Native Americans</a> of the <a href="/wiki/Mandan" title="Mandan">Mandan</a> tribe who were affected by piebaldism.<sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p><p>Historically, persons with extensive piebaldism have experienced abuse of the sort still suffered in the present by albinos, especially in Africa. This has ranged from display of unclothed African piebalds in "freak" shows and postcards of the early 20th century to the forcing of piebalds (as in the case of albinos) to work long hours exposed to the sun (producing high rates of lethal skin cancers), to the use of piebald humans, including children, in risky medical experiments. The National Organization of Albinism and Hypopigmentation, as well as organizations such as <a href="/wiki/Under_the_Same_Sun" title="Under the Same Sun">Under the Same Sun</a>, work to promote awareness of all forms of cutaneous variation and their medical implications, and to highlight human rights issues, especially the plight of albinos subject to extreme persecution in parts of Africa.<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Etymology">Etymology</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Piebaldism&action=edit&section=4" title="Edit section: Etymology"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The word "piebald" originates from a combination of "pie," from "<a href="/wiki/Magpie" title="Magpie">magpie</a>", and "bald", meaning "white patch" or spot.<sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> The reference is to the distinctive black-and-white plumage of the magpie.<sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Piebaldism&action=edit&section=5" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1184024115">.mw-parser-output .div-col{margin-top:0.3em;column-width:30em}.mw-parser-output .div-col-small{font-size:90%}.mw-parser-output .div-col-rules{column-rule:1px solid #aaa}.mw-parser-output .div-col dl,.mw-parser-output .div-col ol,.mw-parser-output .div-col ul{margin-top:0}.mw-parser-output .div-col li,.mw-parser-output .div-col dd{page-break-inside:avoid;break-inside:avoid-column}</style><div class="div-col" style="column-width: 30em;"> <ul><li><a href="/wiki/Albinism" title="Albinism">Albinism</a></li> <li><a href="/wiki/Amelanism" title="Amelanism">Amelanism</a></li> <li><a href="/wiki/Dyschromia" title="Dyschromia">Dyschromia</a></li> <li><a href="/wiki/Erythrism" title="Erythrism">Erythrism</a></li> <li><a href="/wiki/Mosaic_(genetics)" title="Mosaic (genetics)">Mosaic (Genetics)</a></li> <li><a href="/wiki/PAX3" title="PAX3">PAX3</a></li> <li><a href="/wiki/Heterochromia_iridum" title="Heterochromia iridum">Heterochromia iridum</a></li> <li><a href="/wiki/Leucism" title="Leucism">Leucism</a></li> <li><a href="/wiki/Melanism" title="Melanism">Melanism</a></li> <li><a href="/wiki/Piebald" title="Piebald">Piebald</a></li> <li><a href="/wiki/Poliosis" title="Poliosis">Poliosis</a></li> <li><a href="/wiki/Skewbald" title="Skewbald">Skewbald</a></li> <li><a href="/wiki/Vitiligo" title="Vitiligo">Vitiligo</a></li> <li><a href="/wiki/Waardenburg_syndrome" title="Waardenburg syndrome">Waardenburg syndrome</a></li> <li><a href="/wiki/Xanthochromism" title="Xanthochromism">Xanthochromism</a></li></ul></div> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Piebaldism&action=edit&section=6" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-1">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20190416133504/https://rarediseases.info.nih.gov/diseases/4344/disease">"Piebaldism | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program"</a>. <i>rarediseases.info.nih.gov</i>. Archived from <a rel="nofollow" class="external text" href="https://rarediseases.info.nih.gov/diseases/4344/disease">the original</a> on 16 April 2019<span class="reference-accessdate">. Retrieved <span class="nowrap">16 April</span> 2019</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=rarediseases.info.nih.gov&rft.atitle=Piebaldism+%7C+Genetic+and+Rare+Diseases+Information+Center+%28GARD%29+%E2%80%93+an+NCATS+Program&rft_id=https%3A%2F%2Frarediseases.info.nih.gov%2Fdiseases%2F4344%2Fdisease&rfr_id=info%3Asid%2Fen.wikipedia.org%3APiebaldism" class="Z3988"></span></span> </li> <li id="cite_note-Andrews-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-Andrews_2-0">^</a></b></span> <span class="reference-text">James, William; Berger, Timothy; Elston, Dirk (2005). <i>Andrews' Diseases of the Skin: Clinical Dermatology</i>. (10th ed.). Saunders. <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/0-7216-2921-0" title="Special:BookSources/0-7216-2921-0">0-7216-2921-0</a>.</span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/gtr/conditions/C0080024/">"Partial Albinism"</a><span class="reference-accessdate">. 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(1991). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC52576">"Mutation of the KIT (mast/stem cell growth factor receptor) protooncogene in human piebaldism"</a>. <i>Proceedings of the National Academy of Sciences</i>. <b>88</b> (19): 8696–9. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1991PNAS...88.8696G">1991PNAS...88.8696G</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1073%2Fpnas.88.19.8696">10.1073/pnas.88.19.8696</a></span>. <a href="/wiki/JSTOR_(identifier)" class="mw-redirect" title="JSTOR (identifier)">JSTOR</a> <a rel="nofollow" class="external text" href="https://www.jstor.org/stable/2358007">2358007</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC52576">52576</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/1717985">1717985</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences&rft.atitle=Mutation+of+the+KIT+%28mast%2Fstem+cell+growth+factor+receptor%29+protooncogene+in+human+piebaldism&rft.volume=88&rft.issue=19&rft.pages=8696-9&rft.date=1991&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC52576%23id-name%3DPMC&rft_id=https%3A%2F%2Fwww.jstor.org%2Fstable%2F2358007%23id-name%3DJSTOR&rft_id=info%3Abibcode%2F1991PNAS...88.8696G&rft_id=info%3Apmid%2F1717985&rft_id=info%3Adoi%2F10.1073%2Fpnas.88.19.8696&rft.aulast=Giebel&rft.aufirst=L.+B.&rft.au=Spritz%2C+R.+A.&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC52576&rfr_id=info%3Asid%2Fen.wikipedia.org%3APiebaldism" class="Z3988"></span></span> </li> <li id="cite_note-pmid12955764-6"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid12955764_6-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSánchez-MartínPérez-LosadaRodríguez-García2003" class="citation journal cs1">Sánchez-Martín M, Pérez-Losada J, Rodríguez-García A, et al. (October 2003). "Deletion of the SLUG (SNAI2) gene results in human piebaldism". <i>Am. J. Med. Genet. A</i>. <b>122A</b> (2): 125–32. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fajmg.a.20345">10.1002/ajmg.a.20345</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12955764">12955764</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:33811699">33811699</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Am.+J.+Med.+Genet.+A&rft.atitle=Deletion+of+the+SLUG+%28SNAI2%29+gene+results+in+human+piebaldism&rft.volume=122A&rft.issue=2&rft.pages=125-32&rft.date=2003-10&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A33811699%23id-name%3DS2CID&rft_id=info%3Apmid%2F12955764&rft_id=info%3Adoi%2F10.1002%2Fajmg.a.20345&rft.aulast=S%C3%A1nchez-Mart%C3%ADn&rft.aufirst=M&rft.au=P%C3%A9rez-Losada%2C+J&rft.au=Rodr%C3%ADguez-Garc%C3%ADa%2C+A&rfr_id=info%3Asid%2Fen.wikipedia.org%3APiebaldism" class="Z3988"></span></span> </li> <li id="cite_note-7"><span class="mw-cite-backlink"><b><a href="#cite_ref-7">^</a></b></span> <span class="reference-text">Victor A. McKusick, <i>Mendelian Inheritance in Man: A Catalog of Human Genes and Genetic Disorders</i>, Volume 1 (Johns Hopkins University Press, 1428-1429)</span> </li> <li id="cite_note-8"><span class="mw-cite-backlink"><b><a href="#cite_ref-8">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSpritz1997" class="citation journal cs1">Spritz, RA (1997). "Piebaldism, Waardenburg syndrome, and related disorders of melanocyte development". <i>Seminars in Cutaneous Medicine and Surgery</i>. <b>16</b> (1): 15–23. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fs1085-5629%2897%2980031-4">10.1016/s1085-5629(97)80031-4</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9125761">9125761</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Seminars+in+Cutaneous+Medicine+and+Surgery&rft.atitle=Piebaldism%2C+Waardenburg+syndrome%2C+and+related+disorders+of+melanocyte+development&rft.volume=16&rft.issue=1&rft.pages=15-23&rft.date=1997&rft_id=info%3Adoi%2F10.1016%2Fs1085-5629%2897%2980031-4&rft_id=info%3Apmid%2F9125761&rft.aulast=Spritz&rft.aufirst=RA&rfr_id=info%3Asid%2Fen.wikipedia.org%3APiebaldism" class="Z3988"></span></span> </li> <li id="cite_note-9"><span class="mw-cite-backlink"><b><a href="#cite_ref-9">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHarper,_Douglas" class="citation web cs1">Harper, Douglas. <a rel="nofollow" class="external text" href="http://www.etymonline.com/index.php?term=piebald&allowed_in_frame=0">"Piebald"</a>. <i>Online Etymology Dictionary</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Online+Etymology+Dictionary&rft.atitle=Piebald&rft.au=Harper%2C+Douglas&rft_id=http%3A%2F%2Fwww.etymonline.com%2Findex.php%3Fterm%3Dpiebald%26allowed_in_frame%3D0&rfr_id=info%3Asid%2Fen.wikipedia.org%3APiebaldism" class="Z3988"></span></span> </li> <li id="cite_note-10"><span class="mw-cite-backlink"><b><a href="#cite_ref-10">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSkeat,_Walter_W.1882" class="citation book cs1">Skeat, Walter W. (1882). <a rel="nofollow" class="external text" href="https://books.google.com/books?id=YAF6AAAAIAAJ&q=piebald"><i>The Concise Dictionary of English Etymology</i></a>. Hertfordshire: Clarendon Press. p. 442.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=The+Concise+Dictionary+of+English+Etymology&rft.place=Hertfordshire&rft.pages=442&rft.pub=Clarendon+Press&rft.date=1882&rft.au=Skeat%2C+Walter+W.&rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3DYAF6AAAAIAAJ%26q%3Dpiebald&rfr_id=info%3Asid%2Fen.wikipedia.org%3APiebaldism" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Piebaldism&action=edit&section=7" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1236075235">.mw-parser-output .navbox{box-sizing:border-box;border:1px solid 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dt:last-child::after,.mw-parser-output .hlist li li:last-child::after{content:")";font-weight:normal}.mw-parser-output .hlist ol{counter-reset:listitem}.mw-parser-output .hlist ol>li{counter-increment:listitem}.mw-parser-output .hlist ol>li::before{content:" "counter(listitem)"\a0 "}.mw-parser-output .hlist dd ol>li:first-child::before,.mw-parser-output .hlist dt ol>li:first-child::before,.mw-parser-output .hlist li ol>li:first-child::before{content:" ("counter(listitem)"\a0 "}</style><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"></div><div role="navigation" class="navbox" aria-label="Navbox" style="width:100%; margin:0.5em 0 0.5em 0;;padding:3px"><table class="nowraplinks navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background: #EAECF0;color:black;">Classification</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><div style="position:relative; float:right; font-size:0.8em;"><a href="https://www.wikidata.org/wiki/Q1516083" class="extiw" title="d:Q1516083">D</a></div><div class="hlist" style="text-align:left;"><ul><li><b><a href="/wiki/International_Statistical_Classification_of_Diseases_and_Related_Health_Problems" class="mw-redirect" title="International Statistical Classification of Diseases and Related Health Problems">ICD</a>-<a href="/wiki/ICD-10" title="ICD-10">10</a></b>: <a rel="nofollow" class="external text" href="https://icd.who.int/browse10/2019/en#/E70.3">E70.3</a> (<a href="/wiki/ILDS" class="mw-redirect" title="ILDS">ILDS</a> E70.350)</li><li><b><a href="/wiki/International_Statistical_Classification_of_Diseases_and_Related_Health_Problems" class="mw-redirect" title="International Statistical Classification of Diseases and Related Health Problems">ICD</a>-<a href="/wiki/List_of_ICD-9_codes" title="List of ICD-9 codes">9-CM</a></b>: <a rel="nofollow" class="external text" href="http://www.icd9data.com/getICD9Code.ashx?icd9=709.09">709.09</a></li><li><b><a href="/wiki/Online_Mendelian_Inheritance_in_Man" title="Online Mendelian Inheritance in Man">OMIM</a></b>: <a rel="nofollow" class="external text" href="https://omim.org/entry/172800">172800</a></li><li><b><a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">MeSH</a></b>: <a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?ui=D016116">D016116</a></li><li><b><a href="/wiki/Diseases_Database" title="Diseases Database">DiseasesDB</a></b>: <a rel="nofollow" class="external text" href="http://www.diseasesdatabase.com/ddb29295.htm">29295</a></li></ul></div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background: #EAECF0;color:black;">External resources</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><div class="hlist" style="text-align:left;"><ul><li><b><a href="/wiki/EMedicine" title="EMedicine">eMedicine</a></b>: <a rel="nofollow" class="external text" href="https://emedicine.medscape.com/derm/689-overview">derm/689</a></li><li><b><a href="/wiki/Orphanet" title="Orphanet">Orphanet</a></b>: <a rel="nofollow" class="external text" href="https://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=en&Expert=2884">2884</a></li></ul></div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Cell_surface_receptor_deficiencies" style="padding:3px"><table class="nowraplinks hlist mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><style data-mw-deduplicate="TemplateStyles:r1239400231">.mw-parser-output .navbar{display:inline;font-size:88%;font-weight:normal}.mw-parser-output .navbar-collapse{float:left;text-align:left}.mw-parser-output .navbar-boxtext{word-spacing:0}.mw-parser-output .navbar ul{display:inline-block;white-space:nowrap;line-height:inherit}.mw-parser-output .navbar-brackets::before{margin-right:-0.125em;content:"[ "}.mw-parser-output .navbar-brackets::after{margin-left:-0.125em;content:" ]"}.mw-parser-output .navbar li{word-spacing:-0.125em}.mw-parser-output .navbar a>span,.mw-parser-output .navbar a>abbr{text-decoration:inherit}.mw-parser-output .navbar-mini abbr{font-variant:small-caps;border-bottom:none;text-decoration:none;cursor:inherit}.mw-parser-output .navbar-ct-full{font-size:114%;margin:0 7em}.mw-parser-output .navbar-ct-mini{font-size:114%;margin:0 4em}html.skin-theme-clientpref-night .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}@media(prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}}@media print{.mw-parser-output .navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Cell_surface_receptor_deficiencies" title="Template:Cell surface receptor deficiencies"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Cell_surface_receptor_deficiencies" title="Template talk:Cell surface receptor deficiencies"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Cell_surface_receptor_deficiencies" title="Special:EditPage/Template:Cell surface receptor deficiencies"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Cell_surface_receptor_deficiencies" style="font-size:114%;margin:0 4em"><a href="/wiki/Cell_surface_receptor" title="Cell surface receptor">Cell surface receptor</a> deficiencies</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/G_protein-coupled_receptor" title="G protein-coupled receptor">G protein-coupled receptor</a><br />(including <a href="/wiki/Hormone_receptor" title="Hormone receptor">hormone</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Class A</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Thyrotropin_receptor" title="Thyrotropin receptor">TSHR</a></i> (<a href="/wiki/Congenital_hypothyroidism" title="Congenital hypothyroidism">Congenital hypothyroidism 1</a>)</li> <li><i><a href="/wiki/Luteinizing_hormone/choriogonadotropin_receptor" title="Luteinizing hormone/choriogonadotropin receptor">LHCGR</a></i> (<a href="/wiki/Luteinizing_hormone_insensitivity" class="mw-redirect" title="Luteinizing hormone insensitivity">Luteinizing hormone insensitivity</a>, <a href="/wiki/Leydig_cell_hypoplasia" title="Leydig cell hypoplasia">Leydig cell hypoplasia</a>, <a href="/wiki/Male-limited_precocious_puberty" class="mw-redirect" title="Male-limited precocious puberty">Male-limited precocious puberty</a>)</li> <li><i><a href="/wiki/FSH-receptor" class="mw-redirect" title="FSH-receptor">FSHR</a></i> (<a href="/wiki/Follicle-stimulating_hormone_insensitivity" title="Follicle-stimulating hormone insensitivity">Follicle-stimulating hormone insensitivity</a>, <a href="/wiki/XX_gonadal_dysgenesis" title="XX gonadal dysgenesis">XX gonadal dysgenesis</a>)</li> <li><i><a href="/wiki/Gonadotropin-releasing_hormone_receptor" title="Gonadotropin-releasing hormone receptor">GnRHR</a></i> (<a href="/wiki/Gonadotropin-releasing_hormone_insensitivity" title="Gonadotropin-releasing hormone insensitivity">Gonadotropin-releasing hormone insensitivity</a>)</li> <li><i><a href="/wiki/Endothelin_receptor" title="Endothelin receptor">EDNRB</a></i> (<a href="/wiki/ABCD_syndrome" title="ABCD syndrome">ABCD syndrome</a>, <a href="/wiki/Waardenburg_syndrome" title="Waardenburg syndrome">Waardenburg syndrome 4a</a>, <a href="/wiki/Hirschsprung%27s_disease" title="Hirschsprung's disease">Hirschsprung's disease 2</a>)</li> <li><i><a href="/wiki/AVPR2" class="mw-redirect" title="AVPR2">AVPR2</a></i> (<a href="/wiki/Nephrogenic_diabetes_insipidus" title="Nephrogenic diabetes insipidus">Nephrogenic diabetes insipidus 1</a>)</li> <li><i><a href="/wiki/Prostaglandin_E2_receptor" title="Prostaglandin E2 receptor">PTGER2</a></i> (<a href="/wiki/Aspirin-exacerbated_respiratory_disease" title="Aspirin-exacerbated respiratory disease">Aspirin-exacerbated respiratory disease</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Class B</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/PTH1R" class="mw-redirect" title="PTH1R">PTH1R</a></i> (<a href="/wiki/Jansen%27s_metaphyseal_chondrodysplasia" title="Jansen's metaphyseal chondrodysplasia">Jansen's metaphyseal chondrodysplasia</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Class C</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Calcium-sensing_receptor" title="Calcium-sensing receptor">CASR</a></i> (<a href="/wiki/Familial_hypocalciuric_hypercalcemia" title="Familial hypocalciuric hypercalcemia">Familial hypocalciuric hypercalcemia</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Class F</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/FZD4" class="mw-redirect" title="FZD4">FZD4</a></i> (<a href="/wiki/Familial_exudative_vitreoretinopathy" title="Familial exudative vitreoretinopathy">Familial exudative vitreoretinopathy 1</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Enzyme-linked_receptor" title="Enzyme-linked receptor">Enzyme-linked receptor</a><br />(including<br /><a href="/wiki/Growth_factor_receptor" title="Growth factor receptor">growth factor</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Receptor_tyrosine_kinase" title="Receptor tyrosine kinase">RTK</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/ROR2" title="ROR2">ROR2</a></i> (<a href="/wiki/Robinow_syndrome" title="Robinow syndrome">Robinow syndrome</a>)</li> <li><i><a href="/wiki/Fibroblast_growth_factor_receptor_1" title="Fibroblast growth factor receptor 1">FGFR1</a></i> (<a href="/wiki/Pfeiffer_syndrome" title="Pfeiffer syndrome">Pfeiffer syndrome</a>, <a href="/wiki/Kallmann_syndrome" title="Kallmann syndrome">KAL2 Kallmann syndrome</a>)</li> <li><i><a href="/wiki/Fibroblast_growth_factor_receptor_2" title="Fibroblast growth factor receptor 2">FGFR2</a></i> (<a href="/wiki/Apert_syndrome" title="Apert syndrome">Apert syndrome</a>, <a href="/wiki/Antley%E2%80%93Bixler_syndrome" title="Antley–Bixler syndrome">Antley–Bixler syndrome</a>, <a href="/wiki/Pfeiffer_syndrome" title="Pfeiffer syndrome">Pfeiffer syndrome</a>, <a href="/wiki/Crouzon_syndrome" title="Crouzon syndrome">Crouzon syndrome</a>, <a href="/wiki/Jackson%E2%80%93Weiss_syndrome" title="Jackson–Weiss syndrome">Jackson–Weiss syndrome</a>)</li> <li><i><a href="/wiki/Fibroblast_growth_factor_receptor_3" title="Fibroblast growth factor receptor 3">FGFR3</a></i> (<a href="/wiki/Achondroplasia" title="Achondroplasia">Achondroplasia</a>, <a href="/wiki/Hypochondroplasia" title="Hypochondroplasia">Hypochondroplasia</a>, <a href="/wiki/Thanatophoric_dysplasia" title="Thanatophoric dysplasia">Thanatophoric dysplasia</a>, <a href="/wiki/Muenke_syndrome" title="Muenke syndrome">Muenke syndrome</a>)</li> <li><i><a href="/wiki/Insulin_receptor" title="Insulin receptor">INSR</a></i> (<a href="/wiki/Donohue_syndrome" title="Donohue syndrome">Donohue syndrome</a></li> <li><a href="/wiki/Rabson%E2%80%93Mendenhall_syndrome" title="Rabson–Mendenhall syndrome">Rabson–Mendenhall syndrome</a>)</li> <li><i><a href="/wiki/TrkA_receptor" class="mw-redirect" title="TrkA receptor">NTRK1</a></i> (<a href="/wiki/Congenital_insensitivity_to_pain_with_anhidrosis" title="Congenital insensitivity to pain with anhidrosis">Congenital insensitivity to pain with anhidrosis</a>)</li> <li><i><a href="/wiki/CD117" class="mw-redirect" title="CD117">KIT</a></i> (<a class="mw-selflink selflink">KIT Piebaldism</a>, <a href="/wiki/Gastrointestinal_stromal_tumor" title="Gastrointestinal stromal tumor">Gastrointestinal stromal tumor</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Serine/threonine-specific_protein_kinase" title="Serine/threonine-specific protein kinase">STPK</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Anti-M%C3%BCllerian_hormone_receptor" title="Anti-Müllerian hormone receptor">AMHR2</a></i> (<a href="/wiki/Persistent_M%C3%BCllerian_duct_syndrome" title="Persistent Müllerian duct syndrome">Persistent Müllerian duct syndrome II</a>)</li></ul> <ul><li><a href="/wiki/TGF_beta_receptors" class="mw-redirect" title="TGF beta receptors">TGF beta receptors</a>: <a href="/wiki/Endoglin" title="Endoglin">Endoglin</a>/<a href="/wiki/ACVRL1" title="ACVRL1">Alk-1</a>/<a href="/wiki/Mothers_against_decapentaplegic_homolog_4" title="Mothers against decapentaplegic homolog 4">SMAD4</a> (<a href="/wiki/Hereditary_hemorrhagic_telangiectasia" title="Hereditary hemorrhagic telangiectasia">Hereditary hemorrhagic telangiectasia</a>)</li> <li><a href="/wiki/TGF_beta_receptor_1" title="TGF beta receptor 1">TGFBR1</a>/<a href="/wiki/TGF_beta_receptor_2" title="TGF beta receptor 2">TGFBR2</a> (<a href="/wiki/Loeys%E2%80%93Dietz_syndrome" title="Loeys–Dietz syndrome">Loeys–Dietz syndrome</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Guanylate_cyclase" title="Guanylate cyclase">GC</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/GUCY2D" title="GUCY2D">GUCY2D</a></i> (<a href="/wiki/Leber%27s_congenital_amaurosis" class="mw-redirect" title="Leber's congenital amaurosis">Leber's congenital amaurosis 1</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/JAK-STAT_signaling_pathway" title="JAK-STAT signaling pathway">JAK-STAT</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Type_I_cytokine_receptor" title="Type I cytokine receptor">Type I cytokine receptor</a>: <i><a href="/wiki/Growth_hormone_receptor" title="Growth hormone receptor">GH</a></i> (<a href="/wiki/Laron_syndrome" title="Laron syndrome">Laron syndrome</a>)</li> <li><i><a href="/wiki/Granulocyte_macrophage_colony-stimulating_factor_receptor" class="mw-redirect" title="Granulocyte macrophage colony-stimulating factor receptor">CSF2RA</a></i> (<a href="/wiki/Surfactant_metabolism_dysfunction" title="Surfactant metabolism dysfunction">Surfactant metabolism dysfunction 4</a>)</li></ul> <ul><li><a href="/wiki/Myeloproliferative_leukemia_virus_oncogene" class="mw-redirect" title="Myeloproliferative leukemia virus oncogene">MPL</a> (<a href="/wiki/Congenital_amegakaryocytic_thrombocytopenia" title="Congenital amegakaryocytic thrombocytopenia">Congenital amegakaryocytic thrombocytopenia</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Tumor_necrosis_factor_receptor" class="mw-redirect" title="Tumor necrosis factor receptor">TNF receptor</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/TNFRSF1A" class="mw-redirect" title="TNFRSF1A">TNFRSF1A</a></i> (<a href="/wiki/TNF_receptor_associated_periodic_syndrome" title="TNF receptor associated periodic syndrome">TNF receptor associated periodic syndrome</a>)</li> <li><i><a href="/wiki/TNFRSF13B" class="mw-redirect" title="TNFRSF13B">TNFRSF13B</a></i> (<a href="/wiki/Selective_immunoglobulin_A_deficiency" title="Selective immunoglobulin A deficiency">Selective immunoglobulin A deficiency 2</a>)</li> <li><i><a href="/wiki/CD40_(protein)" title="CD40 (protein)">TNFRSF5</a></i> (<a href="/wiki/Hyper-IgM_syndrome_type_3" title="Hyper-IgM syndrome type 3">Hyper-IgM syndrome type 3</a>)</li> <li><i><a href="/wiki/TNFRSF13C" class="mw-redirect" title="TNFRSF13C">TNFRSF13C</a></i> (<a href="/wiki/Common_variable_immunodeficiency" title="Common variable immunodeficiency">CVID4</a>)</li> <li><i><a href="/wiki/TNFRSF13B" class="mw-redirect" title="TNFRSF13B">TNFRSF13B</a></i> (<a href="/wiki/Common_variable_immunodeficiency" title="Common variable immunodeficiency">CVID2</a>)</li> <li><i><a href="/wiki/Fas_receptor" title="Fas receptor">TNFRSF6</a></i> (<a href="/wiki/Autoimmune_lymphoproliferative_syndrome" title="Autoimmune lymphoproliferative syndrome">Autoimmune lymphoproliferative syndrome 1A</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Lipid receptor</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Lipoprotein_receptor-related_protein" title="Lipoprotein receptor-related protein">LRP</a>: <i><a href="/wiki/LRP2" title="LRP2">LRP2</a></i> (<a href="/wiki/Donnai%E2%80%93Barrow_syndrome" title="Donnai–Barrow syndrome">Donnai–Barrow syndrome</a>)</li> <li><i><a href="/wiki/Low_density_lipoprotein_receptor-related_protein_4" class="mw-redirect" title="Low density lipoprotein receptor-related protein 4">LRP4</a></i> (<a href="/wiki/Cenani%E2%80%93Lenz_syndactylism" title="Cenani–Lenz syndactylism">Cenani–Lenz syndactylism</a>)</li> <li><i><a href="/wiki/LRP5" title="LRP5">LRP5</a></i> (<a href="/wiki/Worth_syndrome" title="Worth syndrome">Worth syndrome</a>, <a href="/wiki/Familial_exudative_vitreoretinopathy" title="Familial exudative vitreoretinopathy">Familial exudative vitreoretinopathy 4</a>, <a href="/wiki/Osteopetrosis" title="Osteopetrosis">Osteopetrosis 1</a>)</li></ul> <ul><li><i><a href="/wiki/LDL_receptor" title="LDL receptor">LDLR</a></i> (<a href="/wiki/Familial_hypercholesterolemia" title="Familial hypercholesterolemia">LDLR Familial hypercholesterolemia</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other/ungrouped</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Immunoglobulin_superfamily" title="Immunoglobulin superfamily">Immunoglobulin superfamily</a>: <a href="/wiki/Hypogammaglobulinemia" title="Hypogammaglobulinemia">AGM3, 6</a></li></ul> <ul><li><a href="/wiki/Integrin" title="Integrin">Integrin</a>: <a href="/wiki/Leukocyte_adhesion_deficiency-1" title="Leukocyte adhesion deficiency-1">LAD1</a></li> <li><a href="/wiki/Glanzmann%27s_thrombasthenia" title="Glanzmann's thrombasthenia">Glanzmann's thrombasthenia</a></li> <li><a href="/wiki/Junctional_epidermolysis_bullosa_with_pyloric_atresia" class="mw-redirect" title="Junctional epidermolysis bullosa with pyloric atresia">Junctional epidermolysis bullosa with pyloric atresia</a></li></ul> <p><i><a href="/wiki/EDAR" class="mw-redirect" title="EDAR">EDAR</a></i> (<a href="/wiki/Hypohidrotic_ectodermal_dysplasia" title="Hypohidrotic ectodermal dysplasia">EDAR hypohidrotic ectodermal dysplasia</a>) </p> <ul><li><i><a href="/wiki/PTCH1" title="PTCH1">PTCH1</a></i> (<a href="/wiki/Nevoid_basal-cell_carcinoma_syndrome" title="Nevoid basal-cell carcinoma syndrome">Nevoid basal-cell carcinoma syndrome</a>)</li> <li><i><a href="/wiki/BMPR1A" title="BMPR1A">BMPR1A</a></i> (<a href="/wiki/Juvenile_polyposis_syndrome" title="Juvenile polyposis syndrome">BMPR1A juvenile polyposis syndrome</a>)</li> <li><i><a href="/wiki/IL2RG" class="mw-redirect" title="IL2RG">IL2RG</a></i> (<a href="/wiki/X-linked_severe_combined_immunodeficiency" title="X-linked severe combined immunodeficiency">X-linked severe combined immunodeficiency</a>)</li></ul> <dl><dt>See also</dt> <dd><a href="/wiki/Template:Cell_surface_receptors" title="Template:Cell surface receptors">cell surface receptors</a></dd></dl> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Pigmentation_disorders/Dyschromia" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Pigmentation_disorders" title="Template:Pigmentation disorders"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Pigmentation_disorders" title="Template talk:Pigmentation disorders"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Pigmentation_disorders" title="Special:EditPage/Template:Pigmentation disorders"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Pigmentation_disorders/Dyschromia" style="font-size:114%;margin:0 4em"><a href="/wiki/Pigmentation_disorder" title="Pigmentation disorder">Pigmentation disorders</a>/<a href="/wiki/Dyschromia" title="Dyschromia">Dyschromia</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Hypopigmentation" title="Hypopigmentation">Hypo-</a>/<br /><a href="/wiki/Leucism" title="Leucism">leucism</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Loss of<br /><a href="/wiki/Melanocyte" title="Melanocyte">melanocytes</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Vitiligo" title="Vitiligo">Vitiligo</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Quadrichrome_vitiligo" title="Quadrichrome vitiligo">Quadrichrome vitiligo</a></li> <li><a href="/wiki/Vitiligo_ponctu%C3%A9" title="Vitiligo ponctué">Vitiligo ponctué</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Syndromic</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Alezzandrini_syndrome" title="Alezzandrini syndrome">Alezzandrini syndrome</a></li> <li><a href="/wiki/Vogt%E2%80%93Koyanagi%E2%80%93Harada_syndrome" class="mw-redirect" title="Vogt–Koyanagi–Harada syndrome">Vogt–Koyanagi–Harada syndrome</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Melanocyte<br />development</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a class="mw-selflink selflink">Piebaldism</a></li> <li><a href="/wiki/Waardenburg_syndrome" title="Waardenburg syndrome">Waardenburg syndrome</a></li> <li><a href="/wiki/Tietz_syndrome" title="Tietz syndrome">Tietz syndrome</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Loss of <a href="/wiki/Melanin" title="Melanin">melanin</a>/<br /><a href="/wiki/Amelanism" title="Amelanism">amelanism</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Albinism" title="Albinism">Albinism</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Oculocutaneous_albinism" title="Oculocutaneous albinism">Oculocutaneous albinism</a></li> <li><a href="/wiki/Ocular_albinism" title="Ocular albinism">Ocular albinism</a></li> <li><a href="/wiki/Albinism_in_humans" title="Albinism in humans">in humans</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Melanosome" title="Melanosome">Melanosome</a><br />transfer</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Hermansky%E2%80%93Pudlak_syndrome" title="Hermansky–Pudlak syndrome">Hermansky–Pudlak syndrome</a></li> <li><a href="/wiki/Ch%C3%A9diak%E2%80%93Higashi_syndrome" title="Chédiak–Higashi syndrome">Chédiak–Higashi syndrome</a></li> <li><a href="/wiki/Griscelli_syndrome" title="Griscelli syndrome">Griscelli syndrome</a> <ul><li><a href="/wiki/Elejalde_syndrome" title="Elejalde syndrome">Elejalde syndrome</a></li> <li><a href="/wiki/Griscelli_syndrome_type_2" title="Griscelli syndrome type 2">Griscelli syndrome type 2</a></li> <li><a href="/wiki/Griscelli_syndrome_type_3" title="Griscelli syndrome type 3">Griscelli syndrome type 3</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cross_syndrome" title="Cross syndrome">Cross syndrome</a></li> <li><a href="/wiki/ABCD_syndrome" title="ABCD syndrome">ABCD syndrome</a></li> <li><a href="/wiki/Albinism%E2%80%93deafness_syndrome" title="Albinism–deafness syndrome">Albinism–deafness syndrome</a></li> <li><a href="/wiki/Idiopathic_guttate_hypomelanosis" title="Idiopathic guttate hypomelanosis">Idiopathic guttate hypomelanosis</a></li> <li><a href="/wiki/Phylloid_hypomelanosis" title="Phylloid hypomelanosis">Phylloid hypomelanosis</a></li> <li><a href="/wiki/Progressive_macular_hypomelanosis" title="Progressive macular hypomelanosis">Progressive macular hypomelanosis</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Leukoderma" class="mw-redirect" title="Leukoderma">Leukoderma</a> w/o<br />hypomelanosis</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Vasospastic_macule" title="Vasospastic macule">Vasospastic macule</a></li> <li><a href="/wiki/Woronoff%27s_ring" title="Woronoff's ring">Woronoff's ring</a></li> <li><a href="/wiki/Nevus_anemicus" title="Nevus anemicus">Nevus anemicus</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Ungrouped</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Nevus_depigmentosus" title="Nevus depigmentosus">Nevus depigmentosus</a></li> <li><a href="/wiki/Postinflammatory_hypopigmentation" title="Postinflammatory hypopigmentation">Postinflammatory hypopigmentation</a></li> <li><a href="/wiki/Pityriasis_alba" title="Pityriasis alba">Pityriasis alba</a></li> <li><a href="/wiki/Vagabond%27s_leukomelanoderma" title="Vagabond's leukomelanoderma">Vagabond's leukomelanoderma</a></li> <li><a href="/wiki/Yemenite_deaf-blind_hypopigmentation_syndrome" title="Yemenite deaf-blind hypopigmentation syndrome">Yemenite deaf-blind hypopigmentation syndrome</a></li> <li><a href="/wiki/Wende%E2%80%93Bauckus_syndrome" title="Wende–Bauckus syndrome">Wende–Bauckus syndrome</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Hyperpigmentation" title="Hyperpigmentation">Hyper-</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Melanin" title="Melanin">Melanin</a>/<br /><a href="/wiki/Melanosis" title="Melanosis">Melanosis</a>/<br /><a href="/wiki/Melanism" title="Melanism">Melanism</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Reticulated</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Dermatopathia_pigmentosa_reticularis" title="Dermatopathia pigmentosa reticularis">Dermatopathia pigmentosa reticularis</a></li> <li><a href="/wiki/Pigmentatio_reticularis_faciei_et_colli" title="Pigmentatio reticularis faciei et colli">Pigmentatio reticularis faciei et colli</a></li> <li><a href="/wiki/Reticulate_acropigmentation_of_Kitamura" title="Reticulate acropigmentation of Kitamura">Reticulate acropigmentation of Kitamura</a></li> <li><a href="/wiki/Reticular_pigmented_anomaly_of_the_flexures" title="Reticular pigmented anomaly of the flexures">Reticular pigmented anomaly of the flexures</a></li> <li><a href="/wiki/Naegeli%E2%80%93Franceschetti%E2%80%93Jadassohn_syndrome" title="Naegeli–Franceschetti–Jadassohn syndrome">Naegeli–Franceschetti–Jadassohn syndrome</a></li> <li><a href="/wiki/Dyskeratosis_congenita" title="Dyskeratosis congenita">Dyskeratosis congenita</a></li> <li><a href="/wiki/X-linked_reticulate_pigmentary_disorder" title="X-linked reticulate pigmentary disorder">X-linked reticulate pigmentary disorder</a></li> <li><a href="/wiki/Galli%E2%80%93Galli_disease" title="Galli–Galli disease">Galli–Galli disease</a></li> <li><a href="/wiki/Revesz_syndrome" title="Revesz syndrome">Revesz syndrome</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Diffuse/<br />circumscribed</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Lentigo" title="Lentigo">Lentigo</a>/<a href="/wiki/Lentiginosis" title="Lentiginosis">Lentiginosis</a>: <a href="/wiki/Lentigo_simplex" title="Lentigo simplex">Lentigo simplex</a></li> <li><a href="/wiki/Liver_spot" title="Liver spot">Liver spot</a></li> <li><a href="/wiki/Centrofacial_lentiginosis" title="Centrofacial lentiginosis">Centrofacial lentiginosis</a></li> <li><a href="/wiki/Generalized_lentiginosis" title="Generalized lentiginosis">Generalized lentiginosis</a></li> <li><a href="/wiki/Inherited_patterned_lentiginosis_in_black_persons" class="mw-redirect" title="Inherited patterned lentiginosis in black persons">Inherited patterned lentiginosis in black persons</a></li> <li><a href="/wiki/Ink_spot_lentigo" title="Ink spot lentigo">Ink spot lentigo</a></li> <li><a href="/wiki/Lentigo_maligna" title="Lentigo maligna">Lentigo maligna</a></li> <li><a href="/wiki/Mucosal_lentigines" title="Mucosal lentigines">Mucosal lentigines</a></li> <li><a href="/wiki/Partial_unilateral_lentiginosis" title="Partial unilateral lentiginosis">Partial unilateral lentiginosis</a></li> <li><a href="/wiki/PUVA_lentigines" title="PUVA lentigines">PUVA lentigines</a></li></ul> <ul><li><a href="/wiki/Melasma" title="Melasma">Melasma</a></li> <li><a href="/wiki/Erythema_dyschromicum_perstans" title="Erythema dyschromicum perstans">Erythema dyschromicum perstans</a></li> <li><a href="/wiki/Lichen_planus_pigmentosus" class="mw-redirect" title="Lichen planus pigmentosus">Lichen planus pigmentosus</a></li> <li><a href="/wiki/Caf%C3%A9_au_lait_spot" title="Café au lait spot">Café au lait spot</a></li> <li><a href="/wiki/Poikiloderma" title="Poikiloderma">Poikiloderma</a> (<a href="/wiki/Poikiloderma_of_Civatte" title="Poikiloderma of Civatte">Poikiloderma of Civatte</a></li> <li><a href="/wiki/Poikiloderma_vasculare_atrophicans" title="Poikiloderma vasculare atrophicans">Poikiloderma vasculare atrophicans</a>)</li> <li><a href="/wiki/Riehl_melanosis" title="Riehl melanosis">Riehl melanosis</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Linear</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Incontinentia_pigmenti" title="Incontinentia pigmenti">Incontinentia pigmenti</a></li> <li><a href="/wiki/Scratch_dermatitis" title="Scratch dermatitis">Scratch dermatitis</a></li> <li><a href="/wiki/Shiitake_mushroom_dermatitis" title="Shiitake mushroom dermatitis">Shiitake mushroom dermatitis</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other/<br />ungrouped</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Acanthosis_nigricans" title="Acanthosis nigricans">Acanthosis nigricans</a></li> <li><a href="/wiki/Freckle" title="Freckle">Freckle</a></li> <li><a href="/wiki/Familial_progressive_hyperpigmentation" title="Familial progressive hyperpigmentation">Familial progressive hyperpigmentation</a></li> <li><a href="/wiki/Pallister%E2%80%93Killian_syndrome" title="Pallister–Killian syndrome">Pallister–Killian syndrome</a></li> <li><a href="/wiki/Periorbital_hyperpigmentation" title="Periorbital hyperpigmentation">Periorbital hyperpigmentation</a></li> <li><a href="/wiki/Photoleukomelanodermatitis_of_Kobori" title="Photoleukomelanodermatitis of Kobori">Photoleukomelanodermatitis of Kobori</a></li> <li><a href="/wiki/Postinflammatory_hyperpigmentation" title="Postinflammatory hyperpigmentation">Postinflammatory hyperpigmentation</a></li> <li><a href="/wiki/Transient_neonatal_pustular_melanosis" title="Transient neonatal pustular melanosis">Transient neonatal pustular melanosis</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other<br />pigments</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Iron</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Iron_overload" title="Iron overload">Hemochromatosis</a></li> <li><a href="/wiki/Iron_metallic_discoloration" title="Iron metallic discoloration">Iron metallic discoloration</a></li> <li><a href="/wiki/Pigmented_purpuric_dermatosis" title="Pigmented purpuric dermatosis">Pigmented purpuric dermatosis</a> <ul><li><a href="/wiki/Schamberg_disease" title="Schamberg disease">Schamberg disease</a></li> <li><a href="/wiki/Majocchi%27s_disease" title="Majocchi's disease">Majocchi's disease</a></li> <li><a href="/wiki/Gougerot%E2%80%93Blum_syndrome" title="Gougerot–Blum syndrome">Gougerot–Blum syndrome</a></li> <li><a href="/wiki/Doucas_and_Kapetanakis_pigmented_purpura" title="Doucas and Kapetanakis pigmented purpura">Doucas and Kapetanakis pigmented purpura</a>/<a href="/wiki/Eczematid-like_purpura_of_Doucas_and_Kapetanakis" class="mw-redirect" title="Eczematid-like purpura of Doucas and Kapetanakis">Eczematid-like purpura of Doucas and Kapetanakis</a></li> <li><a href="/wiki/Lichen_aureus" title="Lichen aureus">Lichen aureus</a></li> <li><a href="/wiki/Angioma_serpiginosum" title="Angioma serpiginosum">Angioma serpiginosum</a></li></ul></li> <li><a href="/wiki/Hemosiderin_hyperpigmentation" title="Hemosiderin hyperpigmentation">Hemosiderin hyperpigmentation</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other<br />metals</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Argyria" title="Argyria">Argyria</a></li> <li><a href="/wiki/Chrysiasis" title="Chrysiasis">Chrysiasis</a></li> <li><a href="/wiki/Arsenic_poisoning" title="Arsenic poisoning">Arsenic poisoning</a></li> <li><a href="/wiki/Lead_poisoning" title="Lead poisoning">Lead poisoning</a></li> <li><a href="/wiki/Titanium_metallic_discoloration" title="Titanium metallic discoloration">Titanium metallic discoloration</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Carotenosis" title="Carotenosis">Carotenosis</a></li> <li><a href="/wiki/Tar_melanosis" title="Tar melanosis">Tar melanosis</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Dyschromia" title="Dyschromia">Dyschromia</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Dyschromatosis_symmetrica_hereditaria" title="Dyschromatosis symmetrica hereditaria">Dyschromatosis symmetrica hereditaria</a></li> <li><a href="/wiki/Dyschromatosis_universalis_hereditaria" title="Dyschromatosis universalis hereditaria">Dyschromatosis universalis hereditaria</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">See also</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Skin_color" class="mw-redirect" title="Skin color">Skin color</a></li> <li><a href="/wiki/Skin_whitening" title="Skin whitening">Skin whitening</a></li> <li><a href="/wiki/Sun_tanning" title="Sun tanning">Tanning</a> <ul><li><a href="/wiki/Sunless_tanning" title="Sunless tanning">Sunless</a></li></ul></li> <li><a href="/wiki/Tattoo" title="Tattoo">Tattoo</a> <ul><li><a href="/wiki/Tattoo_removal" title="Tattoo removal">removal</a></li></ul></li> <li><a href="/wiki/Depigmentation" title="Depigmentation">Depigmentation</a></li></ul> </div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" href="https://en.wikipedia.org/w/index.php?title=Piebaldism&oldid=1256000378">https://en.wikipedia.org/w/index.php?title=Piebaldism&oldid=1256000378</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Help:Category" title="Help:Category">Categories</a>: <ul><li><a href="/wiki/Category:Amino_acid_metabolism_disorders" title="Category:Amino acid 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