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class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Immunohistochemistry"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.1</span> <span>Immunohistochemistry</span> </div> </a> <ul id="toc-Immunohistochemistry-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Function" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Function"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Function</span> </div> </a> <button aria-controls="toc-Function-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Function subsection</span> </button> <ul id="toc-Function-sublist" class="vector-toc-list"> <li id="toc-Role_in_signaling" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Role_in_signaling"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.1</span> <span>Role in signaling</span> </div> </a> <ul id="toc-Role_in_signaling-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Leukocyte_transmigration" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Leukocyte_transmigration"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.2</span> <span>Leukocyte transmigration</span> </div> </a> <ul id="toc-Leukocyte_transmigration-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Angiogenesis" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Angiogenesis"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.3</span> <span>Angiogenesis</span> </div> </a> <ul id="toc-Angiogenesis-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Role_of_CD31_in_diseases" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Role_of_CD31_in_diseases"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Role of CD31 in diseases</span> </div> </a> <button aria-controls="toc-Role_of_CD31_in_diseases-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Role of CD31 in diseases subsection</span> </button> <ul id="toc-Role_of_CD31_in_diseases-sublist" class="vector-toc-list"> <li id="toc-Cancer" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Cancer"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.1</span> <span>Cancer</span> </div> </a> <ul id="toc-Cancer-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Atherosclerosis" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Atherosclerosis"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.2</span> <span>Atherosclerosis</span> </div> </a> <ul id="toc-Atherosclerosis-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Disseminated_intravascular_coagulation" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Disseminated_intravascular_coagulation"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.3</span> <span>Disseminated intravascular coagulation</span> </div> </a> <ul id="toc-Disseminated_intravascular_coagulation-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Neuroinflammation" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Neuroinflammation"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.4</span> <span>Neuroinflammation</span> </div> </a> <ul id="toc-Neuroinflammation-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>References</span> </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Further_reading" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Further_reading"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>Further reading</span> </div> </a> <ul id="toc-Further_reading-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-External_links" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#External_links"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>External links</span> </div> </a> <ul id="toc-External_links-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header 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</div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">CD31</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. 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class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/CD31" title="CD31 – Portuguese" lang="pt" hreflang="pt" data-title="CD31" data-language-autonym="Português" data-language-local-name="Portuguese" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/PECAM-1" title="PECAM-1 – Russian" lang="ru" hreflang="ru" data-title="PECAM-1" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/PECAM1" title="PECAM1 – Ukrainian" lang="uk" hreflang="uk" data-title="PECAM1" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target"><span>Українська</span></a></li><li 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</div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Mammalian protein found in humans</div> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">PECAM1</th></tr><tr><td colspan="4" style="text-align:center"><span typeof="mw:File"><a href="/wiki/File:PECAM1.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/4/4f/PECAM1.png/250px-PECAM1.png" decoding="async" width="250" height="127" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/4f/PECAM1.png/375px-PECAM1.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/4f/PECAM1.png/500px-PECAM1.png 2x" data-file-width="1920" data-file-height="975" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Available structures</th></tr><tr><th rowspan="2" style="background-color:#c3fdb8;width:43px"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td colspan="2" style="background-color:#eee">Ortholog search: <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/searchResults.html?display=both&term=Q08481%20or%20P16284%20or%20A0A075B727">PDBe</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_name:UniProt%20AND%20rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_accession:Q08481,P16284,A0A075B727">RCSB</a> </span></td></tr><tr><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr style="background-color:#ddd;text-align:center"><th colspan="2">List of PDB id codes</th></tr><tr><td colspan="2" style="background-color:#eee"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2KY5">2KY5</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/5C14">5C14</a></span></p></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><th colspan="4" style="text-align:center;background-color:#ddd">Identifiers</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/8823">PECAM1</a></span>, CD31, CD31/EndoCAM, GPIIA', PECA1, PECAM-1, endoCAM, platelet and endothelial cell adhesion molecule 1, PCAM-1</td></tr><tr><th scope="row" style="background-color:#c3fdb8">External IDs</th><td colspan="3" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/173445">173445</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:97537">97537</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=47925">47925</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=PECAM1">PECAM1</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000261371">PECAM1 - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_17.svg" class="mw-file-description" title="Chromosome 17 (human)"><img alt="Chromosome 17 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/0/00/Ideogram_human_chromosome_17.svg/300px-Ideogram_human_chromosome_17.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/00/Ideogram_human_chromosome_17.svg/450px-Ideogram_human_chromosome_17.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/00/Ideogram_human_chromosome_17.svg/600px-Ideogram_human_chromosome_17.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Chromosome_17_(human)" class="mw-redirect" title="Chromosome 17 (human)">Chromosome 17 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_17_ideogram.svg" class="mw-file-description" title="Chromosome 17 (human)"><img alt="Chromosome 17 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/c7/Human_chromosome_17_ideogram.svg/300px-Human_chromosome_17_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/c7/Human_chromosome_17_ideogram.svg/450px-Human_chromosome_17_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/c7/Human_chromosome_17_ideogram.svg/600px-Human_chromosome_17_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 221.99532323028px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for PECAM1"><img alt="Genomic location for PECAM1" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 228px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for PECAM1"><img alt="Genomic location for PECAM1" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">17q23.3</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">64,319,415 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">64,413,776 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_11.svg" class="mw-file-description" title="Chromosome 11 (mouse)"><img alt="Chromosome 11 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a5/Ideogram_house_mouse_chromosome_11.svg/260px-Ideogram_house_mouse_chromosome_11.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a5/Ideogram_house_mouse_chromosome_11.svg/390px-Ideogram_house_mouse_chromosome_11.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a5/Ideogram_house_mouse_chromosome_11.svg/520px-Ideogram_house_mouse_chromosome_11.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks">Chromosome 11 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_11.svg" class="mw-file-description" title="Chromosome 11 (mouse)"><img alt="Chromosome 11 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/2/2a/Ideogram_of_house_mouse_chromosome_11.svg/300px-Ideogram_of_house_mouse_chromosome_11.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/2a/Ideogram_of_house_mouse_chromosome_11.svg/450px-Ideogram_of_house_mouse_chromosome_11.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/2a/Ideogram_of_house_mouse_chromosome_11.svg/600px-Ideogram_of_house_mouse_chromosome_11.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 251.41487712539px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for PECAM1"><img alt="Genomic location for PECAM1" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 257.4px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for PECAM1"><img alt="Genomic location for PECAM1" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">11|11 E1</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">106,545,043 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">106,641,454 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000261371">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">tendon of biceps brachii</li><br /><li style="line-height: 137%;">visceral pleura</li><br /><li style="line-height: 137%;">lower lobe of lung</li><br /><li style="line-height: 137%;">pericardium</li><br /><li style="line-height: 137%;">right lung</li><br /><li style="line-height: 137%;">parietal pleura</li><br /><li style="line-height: 137%;">monocyte</li><br /><li style="line-height: 137%;">upper lobe of lung</li><br /><li style="line-height: 137%;">epithelium of colon</li><br /><li style="line-height: 137%;">upper lobe of left lung</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000020717">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">right lung lobe</li><br /><li style="line-height: 137%;">left lung</li><br /><li style="line-height: 137%;">left lung lobe</li><br /><li style="line-height: 137%;">vasculature of trunk</li><br /><li style="line-height: 137%;">mesenteric lymph nodes</li><br /><li style="line-height: 137%;">muscle of thigh</li><br /><li style="line-height: 137%;">ascending aorta</li><br /><li style="line-height: 137%;">aortic valve</li><br /><li style="line-height: 137%;">glomerular capillary</li><br /><li style="line-height: 137%;">digastric muscle</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000261371">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:PBB_GE_PECAM1_208982_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/b/b4/PBB_GE_PECAM1_208982_at_fs.png/250px-PBB_GE_PECAM1_208982_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/b4/PBB_GE_PECAM1_208982_at_fs.png/375px-PBB_GE_PECAM1_208982_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/b4/PBB_GE_PECAM1_208982_at_fs.png/500px-PBB_GE_PECAM1_208982_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span><br /><br /><span typeof="mw:File"><a href="/wiki/File:PBB_GE_PECAM1_208983_s_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/9/96/PBB_GE_PECAM1_208983_s_at_fs.png/250px-PBB_GE_PECAM1_208983_s_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/96/PBB_GE_PECAM1_208983_s_at_fs.png/375px-PBB_GE_PECAM1_208983_s_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/96/PBB_GE_PECAM1_208983_s_at_fs.png/500px-PBB_GE_PECAM1_208983_s_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span><br /><br /><span typeof="mw:File"><a href="/wiki/File:PBB_GE_PECAM1_208981_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/3/3c/PBB_GE_PECAM1_208981_at_fs.png/250px-PBB_GE_PECAM1_208981_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/3c/PBB_GE_PECAM1_208981_at_fs.png/375px-PBB_GE_PECAM1_208981_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/3c/PBB_GE_PECAM1_208981_at_fs.png/500px-PBB_GE_PECAM1_208981_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="http://biogps.org/gene/5175/">More reference expression data</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Molecular function</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005515">protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042803">protein homodimerization activity</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Cellular component</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016021">integral component of membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031092">platelet alpha granule membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045121">membrane raft</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030054">cell junction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005886">plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070062">extracellular exosome</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016020">membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005615">extracellular space</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030667">secretory granule membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005737">cytoplasm</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009897">external side of plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030485">smooth muscle contractile fiber</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0044291">cell-cell contact zone</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071944">cell periphery</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Biological process</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050904">diapedesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0072011">glomerular endothelium development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0002576">platelet degranulation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007155">cell adhesion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030198">extracellular matrix organization</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008037">cell recognition</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050900">leukocyte migration</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007165">signal transduction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006909">phagocytosis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043312">neutrophil degranulation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007159">leukocyte cell-cell adhesion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0072672">neutrophil extravasation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0098742">cell-cell adhesion via plasma-membrane adhesion molecules</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001525">angiogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001886">endothelial cell morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007156">homophilic cell adhesion via plasma membrane adhesion molecules</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007266">Rho protein signal transduction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030334">regulation of cell migration</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0035696">monocyte extravasation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042060">wound healing</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042531">positive regulation of tyrosine phosphorylation of STAT protein</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043542">endothelial cell migration</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0090673">endothelial cell-matrix adhesion</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:#eee;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:#c3fdb8">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=5175&rn=1">5175</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=18613&rn=1">18613</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000261371;db=core">ENSG00000261371</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000020717;db=core">ENSMUSG00000020717</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P16284">P16284</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q08481">Q08481</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_000442">NM_000442</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001032378">NM_001032378</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_008816">NM_008816</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001305157">NM_001305157</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001305158">NM_001305158</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_000433">NP_000433</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001027550">NP_001027550</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001292086">NP_001292086</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001292087">NP_001292087</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_032842">NP_032842</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr17:64319415-64413776">Chr 17: 64.32 – 64.41 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr11:106545043-106641454">Chr 11: 106.55 – 106.64 Mb</a></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14878833" class="extiw" title="d:Q14878833">View/Edit Human</a></td><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14878839" class="extiw" title="d:Q14878839">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>Platelet endothelial cell adhesion molecule</b> (PECAM-1) also known as <b>cluster of differentiation 31</b> (CD31) is a <a href="/wiki/Protein" title="Protein">protein</a> that in humans is encoded by the <i>PECAM1</i> <a href="/wiki/Gene" title="Gene">gene</a> found on <a href="/wiki/Chromosome_17" title="Chromosome 17">chromosome17q23.3</a>.<sup id="cite_ref-entrez_5-0" class="reference"><a href="#cite_note-entrez-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid1690453_6-0" class="reference"><a href="#cite_note-pmid1690453-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid8661055_7-0" class="reference"><a href="#cite_note-pmid8661055-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid8921400_8-0" class="reference"><a href="#cite_note-pmid8921400-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> PECAM-1 plays a key role in removing aged neutrophils from the body. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Structure">Structure</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CD31&action=edit&section=1" title="Edit section: Structure"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>PECAM-1 is a highly glycosylated <a href="/wiki/Protein" title="Protein">protein</a> with a mass of approximately 130 kDa.<sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> The structure of this protein was determined by <a href="/wiki/Molecular_cloning" title="Molecular cloning">molecular cloning</a> in 1990, when it was found out that PECAM-1 has an N-terminal domain with 574 amino acids, a transmembrane domain with 19 amino acids and a C-terminal cytoplasmic domain with 118 amino acids. The N-terminal domain consists of six extracellular <a href="/wiki/Ig-like_fold" class="mw-redirect" title="Ig-like fold">Ig-like</a> domains.<sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Interactions">Interactions</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CD31&action=edit&section=2" title="Edit section: Interactions"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>PECAM-1 is a cell-cell adhesion protein<sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> which interacts with other PECAM-1 molecules through homophilic interactions or with non-PECAM-1 molecules through heterophilic interactions<i>.</i><sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> Homophilic interactions between PECAM-1 molecules are mediated by antiparallel interactions between extracellular Ig-like domain 1 and Ig-like domain 2. These interactions are regulated by the level of PECAM-1 expression. Homophilic interactions occur, only when the surface expression of PECAM-1 is high. Otherwise, when expression is low, heterophilic interactions occur.<sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Tissue_distribution">Tissue distribution</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CD31&action=edit&section=3" title="Edit section: Tissue distribution"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>CD31 is normally found on endothelial cells, platelets, macrophages and Kupffer cells, granulocytes, lymphocytes (T cells, B cells, and NK cells), megakaryocytes, and osteoclasts. </p> <div class="mw-heading mw-heading3"><h3 id="Immunohistochemistry">Immunohistochemistry</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CD31&action=edit&section=4" title="Edit section: Immunohistochemistry"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-default-size mw-halign-left" typeof="mw:File/Thumb"><a href="/wiki/File:Epithelioid_angiosarcoma_-_CD31_-_intermed_mag.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/4/4c/Epithelioid_angiosarcoma_-_CD31_-_intermed_mag.jpg/220px-Epithelioid_angiosarcoma_-_CD31_-_intermed_mag.jpg" decoding="async" width="220" height="147" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/4c/Epithelioid_angiosarcoma_-_CD31_-_intermed_mag.jpg/330px-Epithelioid_angiosarcoma_-_CD31_-_intermed_mag.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/4c/Epithelioid_angiosarcoma_-_CD31_-_intermed_mag.jpg/440px-Epithelioid_angiosarcoma_-_CD31_-_intermed_mag.jpg 2x" data-file-width="4272" data-file-height="2848" /></a><figcaption><a href="/wiki/Micrograph" title="Micrograph">Micrograph</a> of an <a href="/wiki/Angiosarcoma" title="Angiosarcoma">angiosarcoma</a> stained with a CD31 <a href="/wiki/Immunohistochemistry" title="Immunohistochemistry">immunostain</a> (dark brown).</figcaption></figure> <p>In <a href="/wiki/Immunohistochemistry" title="Immunohistochemistry">immunohistochemistry</a>, CD31 is used primarily to demonstrate the presence of <a href="/wiki/Endothelium" title="Endothelium">endothelial cells</a> in histological tissue sections. This can help to evaluate the degree of tumor <a href="/wiki/Angiogenesis" title="Angiogenesis">angiogenesis</a>, which can imply a rapidly growing tumor. Malignant endothelial cells also commonly retain the antigen, so that CD31 immunohistochemistry can also be used to demonstrate both <a href="/wiki/Angioma" title="Angioma">angiomas</a> and <a href="/wiki/Angiosarcoma" title="Angiosarcoma">angiosarcomas</a>. It can also be demonstrated in <a href="/wiki/Small_lymphocytic_lymphoma" class="mw-redirect" title="Small lymphocytic lymphoma">small lymphocytic</a> and <a href="/wiki/Lymphoblastic_lymphoma" class="mw-redirect" title="Lymphoblastic lymphoma">lymphoblastic lymphomas</a>, although more specific markers are available for these conditions.<sup id="cite_ref-Leong_14-0" class="reference"><a href="#cite_note-Leong-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> </p> <div style="clear:left;" class=""></div> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CD31&action=edit&section=5" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>PECAM-1 is found on the surface of <a href="/wiki/Platelet" title="Platelet">platelets</a>, <a href="/wiki/Monocyte" title="Monocyte">monocytes</a>, <a href="/wiki/Neutrophil" title="Neutrophil">neutrophils</a>, and some types of <a href="/wiki/T-cell" class="mw-redirect" title="T-cell">T-cells</a>, and makes up a large portion of <a href="/wiki/Endothelium" title="Endothelium">endothelial</a> cell <a href="/wiki/Cell_junction" title="Cell junction">intercellular junctions</a>. The encoded protein is a member of the <a href="/wiki/Immunoglobulin" class="mw-redirect" title="Immunoglobulin">immunoglobulin</a> superfamily and is likely involved in <a href="/wiki/Leukocyte" class="mw-redirect" title="Leukocyte">leukocyte</a> transmigration, <a href="/wiki/Angiogenesis" title="Angiogenesis">angiogenesis</a>, and <a href="/wiki/Integrin" title="Integrin">integrin</a> activation.<sup id="cite_ref-entrez_5-1" class="reference"><a href="#cite_note-entrez-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> CD31 on <a href="/wiki/Endothelial_cell" class="mw-redirect" title="Endothelial cell">endothelial cells</a> binds to the <a href="/wiki/CD38" title="CD38">CD38</a> receptor on <a href="/wiki/Natural_killer_cell" title="Natural killer cell">natural killer cells</a> for those cells to attach to the <a href="/wiki/Endothelium" title="Endothelium">endothelium</a>.<sup id="cite_ref-pmid32245149_15-0" class="reference"><a href="#cite_note-pmid32245149-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid31963337_16-0" class="reference"><a href="#cite_note-pmid31963337-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Role_in_signaling">Role in signaling</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CD31&action=edit&section=6" title="Edit section: Role in signaling"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>PECAM-1 plays a role in <a href="/wiki/Cell_signaling" title="Cell signaling">cell signaling</a>. In the cytoplasmic domain of PECAM-1 are serine and tyrosine residues which are suitable for <a href="/wiki/Phosphorylation" title="Phosphorylation">phosphorylation</a>. After the tyrosine is phosphorylated, PECAM-1 recruits Src homology 2 (SH2) domain–containing signaling proteins. These proteins can then initiate signaling pathways. Of all these proteins, the protein most widely reported as interacting with the PECAM-1 cytoplasmic domain is SH2 domain–containing protein-tyrosine phosphatase <a href="/wiki/SHP-2" class="mw-redirect" title="SHP-2">SHP-2</a>.<sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> Signaling through PECAM-1 leads to the activation of <a href="/wiki/Neutrophil" title="Neutrophil">neutrophils</a>, <a href="/wiki/Monocyte" title="Monocyte">monocytes</a> and <a href="/wiki/Leukocyte" class="mw-redirect" title="Leukocyte">leukocytes</a>.<sup id="cite_ref-18" class="reference"><a href="#cite_note-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Leukocyte_transmigration">Leukocyte transmigration</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CD31&action=edit&section=7" title="Edit section: Leukocyte transmigration"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>PECAM-1 is involved in migration of <a href="/wiki/Monocyte" title="Monocyte">monocytes</a> and <a href="/wiki/Neutrophil" title="Neutrophil">neutrophils</a>,<sup id="cite_ref-19" class="reference"><a href="#cite_note-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Natural_killer_cell" title="Natural killer cell">natural killer cells</a>,<sup id="cite_ref-20" class="reference"><a href="#cite_note-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> Vδ1+ γδ T lymphocytes<sup id="cite_ref-21" class="reference"><a href="#cite_note-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> and CD34+ <a href="/wiki/Hematopoietic_progenitor_cell" class="mw-redirect" title="Hematopoietic progenitor cell">hematopoietic progenitor cells</a><sup id="cite_ref-22" class="reference"><a href="#cite_note-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup> through the endothelial cells. Moreover, PECAM-1 is involved in transendothelial migration of recent thymic emigrants to the secondary lymphoid organs.<sup id="cite_ref-23" class="reference"><a href="#cite_note-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> Mechanism of leukocyte transmigration can be explained by creating a homophilic interaction. In this interaction migrating leukocytes express PECAM-1 on the surface and then they react with PECAM-1 on the surface of endothelial cell.<sup id="cite_ref-24" class="reference"><a href="#cite_note-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Angiogenesis">Angiogenesis</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CD31&action=edit&section=8" title="Edit section: Angiogenesis"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>PECAM-1 is also important for <a href="/wiki/Angiogenesis" title="Angiogenesis">angiogenesis</a> because it enables the formation of new <a href="/wiki/Blood_vessel" title="Blood vessel">blood vessels</a> through the cell-cell adhesion.<sup id="cite_ref-25" class="reference"><a href="#cite_note-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Role_of_CD31_in_diseases">Role of CD31 in diseases</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CD31&action=edit&section=9" title="Edit section: Role of CD31 in diseases"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Cancer">Cancer</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CD31&action=edit&section=10" title="Edit section: Cancer"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>PECAM-1 is expressed by many <a href="/wiki/Solid_tumor" class="mw-redirect" title="Solid tumor">solid tumor</a> cell lines such as <a href="/wiki/Hemangioma" title="Hemangioma">hemangioma</a>, <a href="/wiki/Angiosarcoma" title="Angiosarcoma">angiosarcoma</a>, <a href="/wiki/Kaposi%27s_sarcoma" title="Kaposi's sarcoma">Kaposi’s sarcoma</a>, <a href="/wiki/Breast_cancer" title="Breast cancer">breast carcinoma</a>, <a href="/wiki/Glioblastoma" title="Glioblastoma">glioblastoma</a>, <a href="/wiki/Colorectal_cancer" title="Colorectal cancer">colon carcinoma</a>, skin carcinoma and other tumor cell lines.<sup id="cite_ref-26" class="reference"><a href="#cite_note-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup> On the surface of these tumor cells PECAM-1 mediates the adhesion to endothelial cells.<sup id="cite_ref-27" class="reference"><a href="#cite_note-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup> PECAM-1 modulates tumor growth by the formation of new endothelial cell tubes. In mice, this process can be inhibited using an anti-PECAM-1 <a href="/wiki/Antibody" title="Antibody">antibody</a>.<sup id="cite_ref-28" class="reference"><a href="#cite_note-28"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup> </p><p>Recently, it was found out that elderly patients with <a href="/wiki/Stomach_cancer" title="Stomach cancer">gastric cancer</a> have high concentration of PECAM-1 in the <a href="/wiki/Serum_(blood)" title="Serum (blood)">serum</a>. That suggests that the use of a serum PECAM-1 level can be a good prognostic marker.<sup id="cite_ref-29" class="reference"><a href="#cite_note-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Atherosclerosis">Atherosclerosis</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CD31&action=edit&section=11" title="Edit section: Atherosclerosis"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Inhibition of PECAM-1 leads to a reduction of atherosclerotic lesions in mice.<sup id="cite_ref-30" class="reference"><a href="#cite_note-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup> That means that PECAM-1 is involved in <a href="/wiki/Atherosclerosis" title="Atherosclerosis">atherosclerosis</a>. The exact mechanism, how PECAM-1 contributes to <a href="/wiki/Atherosclerosis" title="Atherosclerosis">atherosclerosis</a> is not known, but there are some theories. PECAM-1 can act as a mechanoresponsive molecule. Or the pathogenesis can be caused by the infiltration of leukocytes mediated by PECAM-1. Finally, <a href="/wiki/Polymorphism_(biology)" title="Polymorphism (biology)">polymorphisms</a> in the PECAM-1 gene can lead to the progression of atherosclerosis.<sup id="cite_ref-31" class="reference"><a href="#cite_note-31"><span class="cite-bracket">[</span>31<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Disseminated_intravascular_coagulation">Disseminated intravascular coagulation</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CD31&action=edit&section=12" title="Edit section: Disseminated intravascular coagulation"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Extensive microvascular <a href="/wiki/Thrombosis" title="Thrombosis">thrombosis</a> and increased microvascular permeability are main characteristics of <a href="/wiki/Disseminated_intravascular_coagulation" title="Disseminated intravascular coagulation">disseminated intravascular coagulation</a>, a fatal complication of sepsis. Patients with this devastating condition have high levels of PECAM-1 in the serum indicating PECAM-1 as a good diagnostic marker. Moreover, PECAM-1 can protect from the development of <a href="/wiki/Disseminated_intravascular_coagulation" title="Disseminated intravascular coagulation">disseminated intravascular coagulation</a> by inhibiting macrophage <a href="/wiki/Pyroptosis" title="Pyroptosis">pyroptosis</a>.<sup id="cite_ref-32" class="reference"><a href="#cite_note-32"><span class="cite-bracket">[</span>32<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Neuroinflammation">Neuroinflammation</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CD31&action=edit&section=13" title="Edit section: Neuroinflammation"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>PECAM-1 contributes to at least two of the nervous system diseases, <a href="/wiki/Multiple_sclerosis" title="Multiple sclerosis">multiple sclerosis</a> and <a href="/wiki/Cerebral_ischaemia" class="mw-redirect" title="Cerebral ischaemia">cerebral ischaemia</a>. First signs of multiple sclerosis are defects in the <a href="/wiki/Blood%E2%80%93brain_barrier" title="Blood–brain barrier">blood brain barrier</a> and leukocyte migration mediated by adhesion molecules such as PECAM-1. Moreover, monocytes in patients with multiple sclerosis express high level of PECAM-1. Cerebral ischaemia is caused by the accumulation of <a href="/wiki/Leukocytes" class="mw-redirect" title="Leukocytes">leukocytes</a>, which then infiltrate brain <a href="/wiki/Parenchyma" title="Parenchyma">parenchyma</a> and release toxic compounds such as oxygen radicals. Interactions between leukocyte and endothelium are mediated by PECAM-1. High levels of soluble PECAM-1 can be used to diagnose both diseases. Increased PECAM-1 levels indicate damage in the blood brain barrier in patients with multiple sclerosis and high PECAM-1 levels can be used as a short-term prediction of a stroke in patients with cerebral ischaemia.<sup id="cite_ref-33" class="reference"><a href="#cite_note-33"><span class="cite-bracket">[</span>33<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CD31&action=edit&section=14" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-refGRCh38Ensembl-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCh38Ensembl_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000261371">GRCh38: Ensembl release 89: ENSG00000261371</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-refGRCm38Ensembl-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCm38Ensembl_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000020717">GRCm38: Ensembl release 89: ENSMUSG00000020717</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome 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no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=5175">"Human PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span 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"PECAM-1 protects against DIC by dampening inflammatory responses via inhibiting macrophage pyroptosis and restoring vascular barrier integrity". <i>Translational Research</i>. <b>222</b>: 1–16. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.trsl.2020.04.005">10.1016/j.trsl.2020.04.005</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/32417429">32417429</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:218678428">218678428</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Translational+Research&rft.atitle=PECAM-1+protects+against+DIC+by+dampening+inflammatory+responses+via+inhibiting+macrophage+pyroptosis+and+restoring+vascular+barrier+integrity&rft.volume=222&rft.pages=1-16&rft.date=2020-08&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A218678428%23id-name%3DS2CID&rft_id=info%3Apmid%2F32417429&rft_id=info%3Adoi%2F10.1016%2Fj.trsl.2020.04.005&rft.aulast=Luo&rft.aufirst=L&rft.au=Xu%2C+M&rft.au=Liao%2C+D&rft.au=Deng%2C+J&rft.au=Mei%2C+H&rft.au=Hu%2C+Y&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACD31" class="Z3988"></span></span> </li> <li id="cite_note-33"><span class="mw-cite-backlink"><b><a href="#cite_ref-33">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKalinowskaLosy2006" class="citation journal cs1">Kalinowska A, Losy J (December 2006). 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"The unfolding tale of PECAM-1". <i>FEBS Letters</i>. <b>540</b> (1–3): 7–14. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0014-5793%2803%2900224-2">10.1016/S0014-5793(03)00224-2</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12681475">12681475</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:21470915">21470915</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=FEBS+Letters&rft.atitle=The+unfolding+tale+of+PECAM-1&rft.volume=540&rft.issue=1%E2%80%933&rft.pages=7-14&rft.date=2003-04&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A21470915%23id-name%3DS2CID&rft_id=info%3Apmid%2F12681475&rft_id=info%3Adoi%2F10.1016%2FS0014-5793%2803%2900224-2&rft.aulast=Jackson&rft.aufirst=DE&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACD31" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFNewmanNewman2003" class="citation journal cs1">Newman PJ, Newman DK (June 2003). <a rel="nofollow" class="external text" href="https://doi.org/10.1161%2F01.ATV.0000071347.69358.D9">"Signal transduction pathways mediated by PECAM-1: new roles for an old molecule in platelet and vascular cell biology"</a>. <i>Arteriosclerosis, Thrombosis, and Vascular Biology</i>. <b>23</b> (6): 953–964. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1161%2F01.ATV.0000071347.69358.D9">10.1161/01.ATV.0000071347.69358.D9</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12689916">12689916</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Arteriosclerosis%2C+Thrombosis%2C+and+Vascular+Biology&rft.atitle=Signal+transduction+pathways+mediated+by+PECAM-1%3A+new+roles+for+an+old+molecule+in+platelet+and+vascular+cell+biology&rft.volume=23&rft.issue=6&rft.pages=953-964&rft.date=2003-06&rft_id=info%3Adoi%2F10.1161%2F01.ATV.0000071347.69358.D9&rft_id=info%3Apmid%2F12689916&rft.aulast=Newman&rft.aufirst=PJ&rft.au=Newman%2C+DK&rft_id=https%3A%2F%2Fdoi.org%2F10.1161%252F01.ATV.0000071347.69358.D9&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACD31" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFIlanMadri2003" class="citation journal cs1">Ilan N, Madri JA (October 2003). 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(November 2010). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984185">"Ig gene-like molecule CD31 plays a nonredundant role in the regulation of T-cell immunity and tolerance"</a>. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. <b>107</b> (45): 19461–19466. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2010PNAS..10719461M">2010PNAS..10719461M</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1073%2Fpnas.1011748107">10.1073/pnas.1011748107</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984185">2984185</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/20978210">20978210</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Ig+gene-like+molecule+CD31+plays+a+nonredundant+role+in+the+regulation+of+T-cell+immunity+and+tolerance&rft.volume=107&rft.issue=45&rft.pages=19461-19466&rft.date=2010-11&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2984185%23id-name%3DPMC&rft_id=info%3Apmid%2F20978210&rft_id=info%3Adoi%2F10.1073%2Fpnas.1011748107&rft_id=info%3Abibcode%2F2010PNAS..10719461M&rft.aulast=Ma&rft.aufirst=L&rft.au=Mauro%2C+C&rft.au=Cornish%2C+GH&rft.au=Chai%2C+JG&rft.au=Coe%2C+D&rft.au=Fu%2C+H&rft.au=Patton%2C+D&rft.au=Okkenhaug%2C+K&rft.au=Franzoso%2C+G&rft.au=Dyson%2C+J&rft.au=Nourshargh%2C+S&rft.au=Marelli-Berg%2C+FM&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2984185&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACD31" class="Z3988"></span></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CD31&action=edit&section=16" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a rel="nofollow" class="external text" href="http://us.ebioscience.com/resources/human-cd-chart.htm">Human CD Antigen Chart (eBioscience)</a></li> <li><a rel="nofollow" class="external text" href="http://us.ebioscience.com/resources/mouse-cd-chart.htm">Mouse CD Antigen Chart (eBioscience)</a></li> <li>Human <a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=PECAM1"><i>PECAM1</i></a> genome location and <a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=PECAM1"><i>PECAM1</i></a> gene details page in the <a href="/wiki/UCSC_Genome_Browser" title="UCSC Genome Browser">UCSC Genome Browser</a>.</li> <li>Overview of all the structural information available in the <a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a> for <a href="/wiki/UniProt" title="UniProt">UniProt</a>: <i><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/P16284">P16284</a></i> (Platelet endothelial cell adhesion molecule) at the <a href="/wiki/PDBe-KB" title="PDBe-KB">PDBe-KB</a>.</li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output .hlist 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differentiation"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Clusters_of_differentiation" title="Template talk:Clusters of differentiation"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Clusters_of_differentiation" title="Special:EditPage/Template:Clusters of differentiation"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Proteins:_clusters_of_differentiation_(see_also_list_of_human_clusters_of_differentiation)" style="font-size:114%;margin:0 4em"><a href="/wiki/Protein" title="Protein">Proteins</a>: <a href="/wiki/Cluster_of_differentiation" title="Cluster of differentiation">clusters of differentiation</a> (see also <a href="/wiki/List_of_human_clusters_of_differentiation" title="List of human clusters of differentiation">list of human clusters of differentiation</a>)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">1–50</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CD1" title="CD1">CD1</a> <ul><li><a href="/wiki/Group_1_CD1" class="mw-redirect" title="Group 1 CD1">a-c</a></li> <li><a href="/wiki/CD1A" title="CD1A">1A</a></li> <li><a href="/wiki/CD1b" title="CD1b">1B</a></li> <li><a href="/wiki/CD1D" title="CD1D">1D</a></li> <li><a href="/wiki/CD1E" title="CD1E">1E</a></li></ul></li> <li><a href="/wiki/CD2" title="CD2">CD2</a></li> <li><a href="/wiki/CD3_(immunology)" title="CD3 (immunology)">CD3</a> <ul><li><a href="/wiki/CD3G" title="CD3G">γ</a></li> <li><a href="/wiki/CD3D" title="CD3D">δ</a></li> <li><a href="/wiki/CD3E" class="mw-redirect" title="CD3E">ε</a></li></ul></li> <li><a href="/wiki/CD4" title="CD4">CD4</a></li> <li><a href="/wiki/CD5_(protein)" title="CD5 (protein)">CD5</a></li> <li><a href="/wiki/CD6" title="CD6">CD6</a></li> <li><a href="/wiki/CD7" title="CD7">CD7</a></li> <li><a href="/wiki/CD8" title="CD8">CD8</a> <ul><li><a href="/wiki/CD8A" title="CD8A">a</a></li></ul></li> <li><a href="/wiki/CD9" title="CD9">CD9</a></li> <li><a href="/wiki/Neprilysin" title="Neprilysin">CD10</a></li> <li><i>CD11</i> <ul><li><a href="/wiki/CD11a" class="mw-redirect" title="CD11a">a</a></li> <li><a href="/wiki/Integrin_alpha_M" title="Integrin alpha M">b</a></li> <li><a href="/wiki/CD11c" class="mw-redirect" title="CD11c">c</a></li> <li><a href="/wiki/ITGAD" class="mw-redirect" title="ITGAD">d</a></li></ul></li> <li><a href="/wiki/Alanine_aminopeptidase" title="Alanine aminopeptidase">CD13</a></li> <li><a href="/wiki/CD14" title="CD14">CD14</a></li> <li><a href="/wiki/CD15" class="mw-redirect" title="CD15">CD15</a></li> <li><a href="/wiki/CD16" title="CD16">CD16</a> <ul><li><a href="/wiki/FCGR3A" title="FCGR3A">A</a></li> <li><a href="/wiki/FCGR3B" title="FCGR3B">B</a></li></ul></li> <li><a href="/wiki/CD18" class="mw-redirect" title="CD18">CD18</a></li> <li><a href="/wiki/CD19" title="CD19">CD19</a></li> <li><a href="/wiki/CD20" title="CD20">CD20</a></li> <li><a href="/wiki/Complement_receptor_2" title="Complement receptor 2">CD21</a></li> <li><a href="/wiki/CD22" title="CD22">CD22</a></li> <li><a href="/wiki/CD23" title="CD23">CD23</a></li> <li><a href="/wiki/CD24" title="CD24">CD24</a></li> <li><a href="/wiki/IL2RA" title="IL2RA">CD25</a></li> <li><a href="/wiki/Dipeptidyl_peptidase-4" title="Dipeptidyl peptidase-4">CD26</a></li> <li><a href="/wiki/CD27" title="CD27">CD27</a></li> <li><a href="/wiki/CD28" title="CD28">CD28</a></li> <li><a href="/wiki/Integrin_beta_1" title="Integrin beta 1">CD29</a></li> <li><a href="/wiki/CD30" title="CD30">CD30</a></li> <li><a class="mw-selflink selflink">CD31</a></li> <li><a href="/wiki/CD32" title="CD32">CD32</a> <ul><li><a href="/wiki/FCGR2A" title="FCGR2A">A</a></li> <li><a href="/wiki/FCGR2B" title="FCGR2B">B</a></li></ul></li> <li><a href="/wiki/CD33" title="CD33">CD33</a></li> <li><a href="/wiki/CD34" title="CD34">CD34</a></li> <li><a href="/wiki/Complement_receptor_1" title="Complement receptor 1">CD35</a></li> <li><a href="/wiki/CD36" title="CD36">CD36</a></li> <li><a href="/wiki/CD37" title="CD37">CD37</a></li> <li><a href="/wiki/CD38" title="CD38">CD38</a></li> <li><a href="/wiki/ENTPD1" title="ENTPD1">CD39</a></li> <li><a href="/wiki/CD40_(protein)" title="CD40 (protein)">CD40</a></li> <li><a href="/wiki/ITGA2B" class="mw-redirect" title="ITGA2B">CD41</a></li> <li><a href="/wiki/Glycoprotein_Ib" title="Glycoprotein Ib">CD42</a> <ul><li><a href="/wiki/Glycoprotein_IX" title="Glycoprotein IX">a</a></li> <li><a href="/wiki/GP1BA" title="GP1BA">b</a></li> <li><a href="/wiki/GP1BB" title="GP1BB">c</a></li> <li><a href="/wiki/GP5_(gene)" title="GP5 (gene)">d</a></li></ul></li> <li><a href="/wiki/CD43" title="CD43">CD43</a></li> <li><a href="/wiki/CD44" title="CD44">CD44</a></li> <li><a href="/wiki/PTPRC" title="PTPRC">CD45</a></li> <li><a href="/wiki/CD46" title="CD46">CD46</a></li> <li><a href="/wiki/CD47" title="CD47">CD47</a></li> <li><a href="/wiki/CD48" title="CD48">CD48</a></li> <li><i>CD49</i> <ul><li><a href="/wiki/CD49a" class="mw-redirect" title="CD49a">a</a></li> <li><a href="/wiki/CD49b" class="mw-redirect" title="CD49b">b</a></li> <li><a href="/wiki/CD49c" class="mw-redirect" title="CD49c">c</a></li> <li><a href="/wiki/CD49d" class="mw-redirect" title="CD49d">d</a></li> <li><a href="/wiki/ITGA5" class="mw-redirect" title="ITGA5">e</a></li> <li><a href="/wiki/ITGA6" class="mw-redirect" title="ITGA6">f</a></li></ul></li> <li><a href="/wiki/ICAM3" title="ICAM3">CD50</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">51–100</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/ITGAV" class="mw-redirect" title="ITGAV">CD51</a></li> <li><a href="/wiki/CD52" title="CD52">CD52</a></li> <li><a href="/wiki/CD53" title="CD53">CD53</a></li> <li><a href="/wiki/ICAM-1" title="ICAM-1">CD54</a></li> <li><a href="/wiki/Decay-accelerating_factor" title="Decay-accelerating factor">CD55</a></li> <li><a href="/wiki/Neural_cell_adhesion_molecule" title="Neural cell adhesion molecule">CD56</a></li> <li><a href="/wiki/B3GAT1" title="B3GAT1">CD57</a></li> <li><a href="/wiki/CD58" title="CD58">CD58</a></li> <li><a href="/wiki/CD59" title="CD59">CD59</a></li> <li><a href="/wiki/CD61" class="mw-redirect" title="CD61">CD61</a></li> <li><a href="/wiki/Selectin" title="Selectin">CD62</a> <ul><li><a href="/wiki/E-selectin" title="E-selectin">E</a></li> <li><a href="/wiki/L-selectin" title="L-selectin">L</a></li> <li><a href="/wiki/P-selectin" title="P-selectin">P</a></li></ul></li> <li><a href="/wiki/CD63" title="CD63">CD63</a></li> <li><a href="/wiki/CD64_(biology)" title="CD64 (biology)">CD64</a> <ul><li><a href="/wiki/FCGR1A" title="FCGR1A">A</a></li> <li><a href="/wiki/FCGR1B" class="mw-redirect" title="FCGR1B">B</a></li> <li><a href="/wiki/FCGR1C" class="mw-redirect" title="FCGR1C">C</a></li></ul></li> <li><a href="/wiki/Carcinoembryonic_antigen" title="Carcinoembryonic antigen">CD66</a> <ul><li><a href="/wiki/CEACAM1" title="CEACAM1">a</a></li> <li><a href="/wiki/CEACAM8" title="CEACAM8">b</a></li> <li><a href="/wiki/CEACAM6" title="CEACAM6">c</a></li> <li><a href="/wiki/CEACAM3" title="CEACAM3">d</a></li> <li><a href="/wiki/CEACAM5" title="CEACAM5">e</a></li> <li><a href="/wiki/PSG1_(gene)" class="mw-redirect" title="PSG1 (gene)">f</a></li></ul></li> <li><a href="/wiki/CD68" title="CD68">CD68</a></li> <li><a href="/wiki/CD69" title="CD69">CD69</a></li> <li><a href="/wiki/CD70" title="CD70">CD70</a></li> <li><a href="/wiki/TFRC" class="mw-redirect" title="TFRC">CD71</a></li> <li><a href="/wiki/CD72" title="CD72">CD72</a></li> <li><a href="/wiki/NT5E" title="NT5E">CD73</a></li> <li><a href="/wiki/CD74" title="CD74">CD74</a></li> <li><a href="/wiki/CD78" title="CD78">CD78</a></li> <li><a href="/wiki/CD79" title="CD79">CD79</a> <ul><li><a href="/wiki/CD79A" title="CD79A">a</a></li> <li><a href="/wiki/CD79B" title="CD79B">b</a></li></ul></li> <li><a href="/wiki/CD80" title="CD80">CD80</a></li> <li><a href="/wiki/CD81" title="CD81">CD81</a></li> <li><a href="/wiki/CD82_(gene)" title="CD82 (gene)">CD82</a></li> <li><a href="/wiki/CD83" title="CD83">CD83</a></li> <li><a href="/wiki/CD84" title="CD84">CD84</a></li> <li><i>CD85</i> <ul><li><a href="/wiki/LILRB3" title="LILRB3">a</a></li> <li><a href="/wiki/LILRB2" title="LILRB2">d</a></li> <li><a href="/wiki/LILRA3" title="LILRA3">e</a></li> <li><a href="/wiki/LILRA2" title="LILRA2">h</a></li> <li><a href="/wiki/LILRB1" title="LILRB1">j</a></li> <li><a href="/wiki/LILRB4" title="LILRB4">k</a></li></ul></li> <li><a href="/wiki/CD86" title="CD86">CD86</a></li> <li><a href="/wiki/Urokinase_receptor" title="Urokinase receptor">CD87</a></li> <li><a href="/wiki/C5a_receptor" title="C5a receptor">CD88</a></li> <li><a href="/wiki/FCAR" title="FCAR">CD89</a></li> <li><a href="/wiki/CD90" title="CD90">CD90</a></li> <li><a href="/wiki/LRP1" title="LRP1">CD91</a> - <a href="/wiki/SLC44A1" class="mw-redirect" title="SLC44A1">CD92</a></li> <li><a href="/wiki/CD93" title="CD93">CD93</a></li> <li><a href="/wiki/KLRD1" title="KLRD1">CD94</a></li> <li><a href="/wiki/Fas_receptor" title="Fas receptor">CD95</a></li> <li><a href="/wiki/CD96" title="CD96">CD96</a></li> <li><a href="/wiki/CD97" title="CD97">CD97</a></li> <li><a href="/wiki/CD98" title="CD98">CD98</a></li> <li><a href="/wiki/CD99" title="CD99">CD99</a></li> <li><a href="/wiki/SEMA4D" title="SEMA4D">CD100</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">101–150</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/IGSF2" title="IGSF2">CD101</a></li> <li><a href="/wiki/ICAM2" title="ICAM2">CD102</a></li> <li><a href="/wiki/ITGAE" title="ITGAE">CD103</a></li> <li><a href="/wiki/ITGB4" class="mw-redirect" title="ITGB4">CD104</a></li> <li><a href="/wiki/Endoglin" title="Endoglin">CD105</a></li> <li><a href="/wiki/VCAM-1" title="VCAM-1">CD106</a></li> <li><i>CD107</i> <ul><li><a href="/wiki/LAMP1" title="LAMP1">a</a></li> <li><a href="/wiki/LAMP2" title="LAMP2">b</a></li></ul></li> <li><a href="/wiki/SEMA7A" title="SEMA7A">CD108</a></li> <li><a href="/wiki/CD109" title="CD109">CD109</a></li> <li><a href="/wiki/Myeloproliferative_leukemia_virus_oncogene" class="mw-redirect" title="Myeloproliferative leukemia virus oncogene">CD110</a></li> <li><a href="/wiki/PVRL1" class="mw-redirect" title="PVRL1">CD111</a></li> <li><a href="/wiki/PVRL2" class="mw-redirect" title="PVRL2">CD112</a></li> <li><a href="/wiki/PVRL3" class="mw-redirect" title="PVRL3">CD113</a></li> <li><a href="/wiki/Granulocyte_colony-stimulating_factor_receptor" title="Granulocyte colony-stimulating factor receptor">CD114</a></li> <li><a href="/wiki/Colony_stimulating_factor_1_receptor" title="Colony stimulating factor 1 receptor">CD115</a></li> <li><a href="/wiki/Granulocyte_macrophage_colony-stimulating_factor_receptor" class="mw-redirect" title="Granulocyte macrophage colony-stimulating factor receptor">CD116</a></li> <li><a href="/wiki/KIT_(gene)" title="KIT (gene)">CD117</a></li> <li><a href="/wiki/Leukemia_inhibitory_factor_receptor" title="Leukemia inhibitory factor receptor">CD118</a></li> <li><a href="/wiki/Interferon_gamma_receptor_1" title="Interferon gamma receptor 1">CD119</a></li> <li><a href="/wiki/CD120" title="CD120">CD120</a> <ul><li><a href="/wiki/TNFRSF1A" class="mw-redirect" title="TNFRSF1A">a</a></li> <li><a href="/wiki/TNFRSF1B" class="mw-redirect" title="TNFRSF1B">b</a></li></ul></li> <li><i>CD121</i> <ul><li><a href="/wiki/Interleukin_1_receptor,_type_I" title="Interleukin 1 receptor, type I">a</a></li> <li><a href="/wiki/Interleukin_1_receptor,_type_II" title="Interleukin 1 receptor, type II">b</a></li></ul></li> <li><a href="/wiki/IL2RB" title="IL2RB">CD122</a></li> <li><a href="/wiki/IL3RA" title="IL3RA">CD123</a></li> <li><a href="/wiki/Interleukin-4_receptor" title="Interleukin-4 receptor">CD124</a></li> <li><a href="/wiki/Interleukin_5_receptor_alpha_subunit" title="Interleukin 5 receptor alpha subunit">CD125</a></li> <li><a href="/wiki/Interleukin-6_receptor" title="Interleukin-6 receptor">CD126</a></li> <li><a href="/wiki/Interleukin-7_receptor" title="Interleukin-7 receptor">CD127</a></li> <li><a href="/wiki/Interleukin-9_receptor" title="Interleukin-9 receptor">CD129</a></li> <li><a href="/wiki/Glycoprotein_130" title="Glycoprotein 130">CD130</a></li> <li><a href="/wiki/CSF2RB" title="CSF2RB">CD131</a></li> <li><a href="/wiki/Common_gamma_chain" title="Common gamma chain">CD132</a></li> <li><a href="/wiki/CD133" title="CD133">CD133</a></li> <li><a href="/wiki/CD134" title="CD134">CD134</a></li> <li><a href="/wiki/CD135" title="CD135">CD135</a></li> <li><a href="/wiki/MST1R" title="MST1R">CD136</a></li> <li><a href="/wiki/CD137" title="CD137">CD137</a></li> <li><a href="/wiki/Syndecan_1" title="Syndecan 1">CD138</a></li> <li><a href="/wiki/PDGFRB" title="PDGFRB">CD140b</a></li> <li><a href="/wiki/Thrombomodulin" title="Thrombomodulin">CD141</a></li> <li><a href="/wiki/Tissue_factor" title="Tissue factor">CD142</a></li> <li><a href="/wiki/Angiotensin-converting_enzyme" title="Angiotensin-converting enzyme">CD143</a></li> <li><a href="/wiki/VE-cadherin" title="VE-cadherin">CD144</a></li> <li><a href="/wiki/CD146" title="CD146">CD146</a></li> <li><a href="/wiki/Basigin" title="Basigin">CD147</a></li> <li><a href="/wiki/PTPRJ" title="PTPRJ">CD148</a></li> <li><a href="/wiki/SLAMF1" title="SLAMF1">CD150</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">151–200</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CD151" title="CD151">CD151</a></li> <li><a href="/wiki/CTLA-4" class="mw-redirect" title="CTLA-4">CD152</a></li> <li><a href="/wiki/CD153" title="CD153">CD153</a></li> <li><a href="/wiki/CD154" title="CD154">CD154</a></li> <li><a href="/wiki/CD155" title="CD155">CD155</a></li> <li><i>CD156</i> <ul><li><a href="/wiki/ADAM8" title="ADAM8">a</a></li> <li><a href="/wiki/ADAM17" title="ADAM17">b</a></li> <li><a href="/wiki/ADAM10" title="ADAM10">c</a></li></ul></li> <li><a href="/wiki/BST1" title="BST1">CD157</a></li> <li><i>CD158</i> (<a href="/wiki/KIR2DL1" title="KIR2DL1">a</a></li> <li><a href="/wiki/KIR2DL4" title="KIR2DL4">d</a></li> <li><a href="/wiki/KIR3DL1" title="KIR3DL1">e</a></li> <li><a href="/wiki/KIR2DS4" title="KIR2DS4">i</a></li> <li><a href="/wiki/KIR3DL2" title="KIR3DL2">k</a>)</li> <li><i>CD159</i> <ul><li><a href="/wiki/NKG2" title="NKG2">a</a></li> <li><a href="/wiki/KLRC2" title="KLRC2">c</a></li></ul></li> <li><a href="/wiki/CD160" title="CD160">CD160</a></li> <li><a href="/wiki/KLRB1" title="KLRB1">CD161</a></li> <li><a href="/wiki/P-selectin_glycoprotein_ligand-1" title="P-selectin glycoprotein ligand-1">CD162</a></li> <li><a href="/wiki/CD163" title="CD163">CD163</a></li> <li><a href="/wiki/CD164" title="CD164">CD164</a></li> <li><a href="/wiki/ALCAM" title="ALCAM">CD166</a></li> <li><i>CD167</i> <ul><li><a href="/wiki/DDR1" title="DDR1">a</a></li> <li><a href="/wiki/Discoidin_domain-containing_receptor_2" title="Discoidin domain-containing receptor 2">b</a></li></ul></li> <li><a href="/wiki/Hyaluronan-mediated_motility_receptor" title="Hyaluronan-mediated motility receptor">CD168</a></li> <li><a href="/wiki/Sialoadhesin" title="Sialoadhesin">CD169</a></li> <li><a href="/wiki/SIGLEC5" title="SIGLEC5">CD170</a></li> <li><a href="/wiki/L1_(protein)" title="L1 (protein)">CD171</a></li> <li><i>CD172</i> <ul><li><a href="/wiki/Signal-regulatory_protein_alpha" title="Signal-regulatory protein alpha">a</a></li> <li><a href="/wiki/SIRPB1" title="SIRPB1">b</a></li> <li><a href="/wiki/SIRPG" title="SIRPG">g</a></li></ul></li> <li><a href="/wiki/Fucosyltransferase_3" title="Fucosyltransferase 3">CD174</a></li> <li><a href="/wiki/CD177" title="CD177">CD177</a></li> <li><a href="/wiki/Fas_ligand" title="Fas ligand">CD178</a></li> <li><i>CD179</i> <ul><li><a href="/wiki/VPREB1" title="VPREB1">a</a></li> <li><a href="/wiki/IGLL1" title="IGLL1">b</a></li></ul></li> <li><a href="/wiki/CD180" title="CD180">CD180</a></li> <li><a href="/wiki/Interleukin_8_receptor,_alpha" title="Interleukin 8 receptor, alpha">CD181</a></li> <li><a href="/wiki/Interleukin_8_receptor,_beta" title="Interleukin 8 receptor, beta">CD182</a></li> <li><a href="/wiki/CXCR3" title="CXCR3">CD183</a></li> <li><a href="/wiki/CXCR4" title="CXCR4">CD184</a></li> <li><a href="/wiki/CXCR5" title="CXCR5">CD185</a></li> <li><a href="/wiki/CXCR6" title="CXCR6">CD186</a></li> <li><a href="/wiki/CCR1" title="CCR1">CD191</a></li> <li><a href="/wiki/CCR2" title="CCR2">CD192</a></li> <li><a href="/wiki/CCR3_(gene)" title="CCR3 (gene)">CD193</a></li> <li><a href="/wiki/CCR4" title="CCR4">CD194</a></li> <li><a href="/wiki/CCR5" title="CCR5">CD195</a></li> <li><a href="/wiki/C-C_chemokine_receptor_type_6" title="C-C chemokine receptor type 6">CD196</a></li> <li><a href="/wiki/C-C_chemokine_receptor_type_7" title="C-C chemokine receptor type 7">CD197</a></li> <li><a href="/wiki/CCR8_(gene)" title="CCR8 (gene)">CDw198</a></li> <li><a href="/wiki/CCR9" title="CCR9">CDw199</a></li> <li><a href="/wiki/CD200" title="CD200">CD200</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">201–250</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Endothelial_protein_C_receptor" title="Endothelial protein C receptor">CD201</a></li> <li><a href="/wiki/TEK_tyrosine_kinase" title="TEK tyrosine kinase">CD202b</a></li> <li><a href="/wiki/MSR1" title="MSR1">CD204</a></li> <li><a href="/wiki/LY75" class="mw-redirect" title="LY75">CD205</a></li> <li><a href="/wiki/Mannose_receptor" title="Mannose receptor">CD206</a></li> <li><a href="/wiki/CD207" class="mw-redirect" title="CD207">CD207</a></li> <li><a href="/wiki/LAMP3" title="LAMP3">CD208</a></li> <li><a href="/wiki/DC-SIGN" title="DC-SIGN">CD209</a></li> <li><i>CDw210</i> <ul><li><a href="/wiki/Interleukin_10_receptor,_alpha_subunit" title="Interleukin 10 receptor, alpha subunit">a</a></li> <li><a href="/wiki/Interleukin_10_receptor,_beta_subunit" title="Interleukin 10 receptor, beta subunit">b</a></li></ul></li> <li><a href="/wiki/Interleukin_12_receptor,_beta_1_subunit" title="Interleukin 12 receptor, beta 1 subunit">CD212</a></li> <li><i>CD213a</i> <ul><li><a href="/wiki/IL13RA1" class="mw-redirect" title="IL13RA1">1</a></li> <li><a href="/wiki/IL13RA2" title="IL13RA2">2</a></li></ul></li> <li><a href="/wiki/IL17RA" title="IL17RA">CD217</a></li> <li><i>CD218</i> (<a href="/wiki/IL18R1" title="IL18R1">a</a></li> <li><a href="/wiki/IL18RAP" title="IL18RAP">b</a>)</li> <li><a href="/wiki/Insulin_receptor" title="Insulin receptor">CD220</a></li> <li><a href="/wiki/Insulin-like_growth_factor_1_receptor" title="Insulin-like growth factor 1 receptor">CD221</a></li> <li><a href="/wiki/Insulin-like_growth_factor_2_receptor" title="Insulin-like growth factor 2 receptor">CD222</a></li> <li><a href="/wiki/LAG3" class="mw-redirect" title="LAG3">CD223</a></li> <li><a href="/wiki/GGT1" class="mw-redirect" title="GGT1">CD224</a></li> <li><a href="/wiki/IFITM1" title="IFITM1">CD225</a></li> <li><a href="/wiki/CD226" title="CD226">CD226</a></li> <li><a href="/wiki/MUC1" class="mw-redirect" title="MUC1">CD227</a></li> <li><a href="/wiki/MFI2" class="mw-redirect" title="MFI2">CD228</a></li> <li><a href="/wiki/LY9" title="LY9">CD229</a></li> <li><a href="/wiki/PRNP" class="mw-redirect" title="PRNP">CD230</a></li> <li><a href="/wiki/Band_3" class="mw-redirect" title="Band 3">CD233</a></li> <li><a href="/wiki/Duffy_antigen_system" title="Duffy antigen system">CD234</a></li> <li><i>CD235</i> <ul><li><a href="/wiki/GYPA" class="mw-redirect" title="GYPA">a</a></li> <li><a href="/wiki/GYPB" title="GYPB">b</a></li></ul></li> <li><a href="/wiki/Glycophorin_C" title="Glycophorin C">CD236</a></li> <li><a href="/wiki/Kell_antigen_system" title="Kell antigen system">CD238</a></li> <li><a href="/wiki/Basal_cell_adhesion_molecule" title="Basal cell adhesion molecule">CD239</a></li> <li><a href="/wiki/RHCE_(gene)" title="RHCE (gene)">CD240CE</a></li> <li><a href="/wiki/RHD_(gene)" title="RHD (gene)">CD240D</a></li> <li><a href="/wiki/RHAG" title="RHAG">CD241</a></li> <li><a href="/wiki/P-glycoprotein" title="P-glycoprotein">CD243</a></li> <li><a href="/wiki/CD244" title="CD244">CD244</a></li> <li><a href="/wiki/Anaplastic_lymphoma_kinase" title="Anaplastic lymphoma kinase">CD246</a></li> <li><a href="/wiki/CD247" class="mw-redirect" title="CD247">CD247</a> - <a href="/wiki/CD248" title="CD248">CD248</a></li> <li><a href="/wiki/Glutamyl_aminopeptidase" title="Glutamyl aminopeptidase">CD249</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">251–300</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/OX40L" class="mw-redirect" title="OX40L"> CD252</a></li> <li><a href="/wiki/TRAIL" title="TRAIL">CD253</a></li> <li><a href="/wiki/RANKL" title="RANKL">CD254</a></li> <li><a href="/wiki/TNFSF13" class="mw-redirect" title="TNFSF13">CD256</a></li> <li><a href="/wiki/B-cell_activating_factor" title="B-cell activating factor">CD257</a></li> <li><a href="/wiki/TNFSF14" class="mw-redirect" title="TNFSF14">CD258</a></li> <li><a href="/wiki/TNFRSF10A" class="mw-redirect" title="TNFRSF10A">CD261</a></li> <li><a href="/wiki/TNFRSF10B" class="mw-redirect" title="TNFRSF10B">CD262</a></li> <li><a href="/wiki/TNFRSF10C" class="mw-redirect" title="TNFRSF10C">CD263</a></li> <li><a href="/wiki/TNFRSF10D" class="mw-redirect" title="TNFRSF10D">CD264</a></li> <li><a href="/wiki/RANK" title="RANK">CD265</a></li> <li><a href="/wiki/TNFRSF12A" title="TNFRSF12A">CD266</a></li> <li><a href="/wiki/TNFRSF13B" class="mw-redirect" title="TNFRSF13B">CD267</a></li> <li><a href="/wiki/TNFRSF13C" class="mw-redirect" title="TNFRSF13C">CD268</a></li> <li><a href="/wiki/TNFRSF17" class="mw-redirect" title="TNFRSF17">CD269</a></li> <li><a href="/wiki/Low-affinity_nerve_growth_factor_receptor" title="Low-affinity nerve growth factor receptor">CD271</a></li> <li><a href="/wiki/BTLA" title="BTLA">CD272</a></li> <li><a href="/wiki/PDCD1LG2" title="PDCD1LG2">CD273</a></li> <li><a href="/wiki/CD274" class="mw-redirect" title="CD274">CD274</a></li> <li><a href="/wiki/ICOSLG" title="ICOSLG">CD275</a></li> <li><a href="/wiki/CD276" title="CD276">CD276</a></li> <li><a href="/wiki/CD278" title="CD278">CD278</a></li> <li><a href="/wiki/Programmed_cell_death_protein_1" title="Programmed cell death protein 1">CD279</a></li> <li><a href="/wiki/Mannose_receptor" title="Mannose receptor">CD280</a></li> <li><a href="/wiki/TLR_1" class="mw-redirect" title="TLR 1">CD281</a></li> <li><a href="/wiki/TLR2" class="mw-redirect" title="TLR2">CD282</a></li> <li><a href="/wiki/TLR3" class="mw-redirect" title="TLR3">CD283</a></li> <li><a href="/wiki/TLR4" class="mw-redirect" title="TLR4">CD284</a></li> <li><a href="/wiki/TLR6" class="mw-redirect" title="TLR6">CD286</a></li> <li><a href="/wiki/TLR8" class="mw-redirect" title="TLR8">CD288</a></li> <li><a href="/wiki/TLR9" class="mw-redirect" title="TLR9">CD289</a></li> <li><a href="/wiki/TLR10" class="mw-redirect" title="TLR10">CD290</a></li> <li><a href="/wiki/BMPR1A" title="BMPR1A">CD292</a></li> <li><a href="/wiki/BMPR1B" title="BMPR1B">CDw293</a></li> <li><a href="/wiki/CD294" class="mw-redirect" title="CD294">CD294</a></li> <li><a href="/wiki/Leptin_receptor" title="Leptin receptor">CD295</a></li> <li><a href="/wiki/ART4" title="ART4">CD297</a></li> <li><a href="/wiki/ATP1B3" title="ATP1B3">CD298</a></li> <li><a href="/wiki/CLEC4M" title="CLEC4M">CD299</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">301–350</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CD300A" title="CD300A">CD300A</a></li> <li><a href="/wiki/CLEC10A" title="CLEC10A">CD301</a></li> <li><a href="/wiki/CD302" title="CD302">CD302</a></li> <li><a href="/wiki/CLEC4C" title="CLEC4C">CD303</a></li> <li><a href="/wiki/Neuropilin" title="Neuropilin">CD304</a></li> <li><a href="/wiki/LAIR1" title="LAIR1">CD305</a></li> <li><a href="/wiki/LAIR2" title="LAIR2">CD306</a></li> <li><a href="/wiki/FCRL5" title="FCRL5">CD307</a></li> <li><a href="/wiki/Kinase_insert_domain_receptor" title="Kinase insert domain receptor">CD309</a></li> <li><a href="/wiki/EMR2" title="EMR2">CD312</a></li> <li><a href="/wiki/NKG2D" title="NKG2D">CD314</a></li> <li><a href="/wiki/PTGFRN" title="PTGFRN">CD315</a></li> <li><a href="/wiki/IGSF8" title="IGSF8">CD316</a></li> <li><a href="/wiki/Tetherin" title="Tetherin">CD317</a></li> <li><a href="/wiki/CDCP1" title="CDCP1">CD318</a></li> <li><a href="/wiki/CD320" title="CD320">CD320</a></li> <li><a href="/wiki/F11_receptor" title="F11 receptor">CD321</a></li> <li><a href="/wiki/JAM2" title="JAM2">CD322</a></li> <li><a href="/wiki/CDH1_(gene)" class="mw-redirect" title="CDH1 (gene)">CD324</a></li> <li><a href="/wiki/CDH2" class="mw-redirect" title="CDH2">CD325</a></li> <li><a href="/wiki/Epithelial_cell_adhesion_molecule" title="Epithelial cell adhesion molecule">CD326</a></li> <li><a href="/wiki/SIGLEC6" title="SIGLEC6">CD327</a></li> <li><a href="/wiki/SIGLEC7" title="SIGLEC7">CD328</a></li> <li><a href="/wiki/SIGLEC9" title="SIGLEC9">CD329</a></li> <li><a href="/wiki/Fibroblast_growth_factor_receptor_1" title="Fibroblast growth factor receptor 1">CD331</a></li> <li><a href="/wiki/Fibroblast_growth_factor_receptor_2" title="Fibroblast growth factor receptor 2">CD332</a></li> <li><a href="/wiki/Fibroblast_growth_factor_receptor_3" title="Fibroblast growth factor receptor 3">CD333</a></li> <li><a href="/wiki/Fibroblast_growth_factor_receptor_4" title="Fibroblast growth factor receptor 4">CD334</a></li> <li><a href="/wiki/NCR1" title="NCR1">CD335</a></li> <li><a href="/wiki/NCR2" title="NCR2">CD336</a></li> <li><a href="/wiki/NCR3" title="NCR3">CD337</a></li> <li><a href="/wiki/ABCG2" title="ABCG2">CD338</a></li> <li><a href="/wiki/JAG1" title="JAG1">CD339</a></li> <li><a href="/wiki/HER2/neu" class="mw-redirect" title="HER2/neu">CD340</a></li> <li><a href="/wiki/FZD4" class="mw-redirect" title="FZD4">CD344</a></li> <li><a href="/wiki/FZD9" class="mw-redirect" title="FZD9">CD349</a></li> <li><a href="/wiki/FZD10" class="mw-redirect" title="FZD10">CD350</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Membrane_proteins:_cell_adhesion_molecules" style="padding:3px"><table class="nowraplinks hlist mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Cell_adhesion_molecules" title="Template:Cell adhesion molecules"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Cell_adhesion_molecules" title="Template talk:Cell adhesion molecules"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Cell_adhesion_molecules" title="Special:EditPage/Template:Cell adhesion molecules"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Membrane_proteins:_cell_adhesion_molecules" style="font-size:114%;margin:0 4em"><a href="/wiki/Membrane_protein" title="Membrane protein">Membrane proteins</a>: <a href="/wiki/Cell_adhesion_molecule" title="Cell adhesion molecule">cell adhesion molecules</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Cell_adhesion_molecule#Calcium-independent" title="Cell adhesion molecule">Calcium-independent</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/IgSF_CAM" title="IgSF CAM">IgSF CAM</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Neural_cell_adhesion_molecule" title="Neural cell adhesion molecule">N-CAM</a> (<a href="/wiki/Myelin_protein_zero" title="Myelin protein zero">Myelin protein zero</a>)</li> <li><a href="/wiki/Intercellular_adhesion_molecule" title="Intercellular adhesion molecule">ICAM</a> (<a href="/wiki/ICAM-1" title="ICAM-1">1</a>, <a href="/wiki/ICAM5" title="ICAM5">5</a>)</li> <li><a href="/wiki/VCAM-1" title="VCAM-1">VCAM-1</a></li> <li><a class="mw-selflink selflink">PE-CAM</a></li> <li><a href="/wiki/L1_family" title="L1 family">L1 family</a> <ul><li><a href="/wiki/L1_(protein)" title="L1 (protein)">L1-CAM</a></li> <li><a href="/wiki/NRCAM" title="NRCAM">NRCAM</a></li> <li><a href="/wiki/NFASC" title="NFASC">NFASC</a></li> <li><a href="/wiki/CHL1" title="CHL1">CHL1</a></li></ul></li> <li><a href="/wiki/Nectin" title="Nectin">Nectin</a> <ul><li><a href="/wiki/PVRL1" class="mw-redirect" title="PVRL1">PVRL1</a></li> <li><a href="/wiki/PVRL2" class="mw-redirect" title="PVRL2">PVRL2</a></li> <li><a href="/wiki/PVRL3" class="mw-redirect" title="PVRL3">PVRL3</a></li> <li><a href="/wiki/CADM1" class="mw-redirect" title="CADM1">CADM1</a></li> <li><a href="/wiki/CADM3" title="CADM3">CADM3</a></li> <li><a href="/wiki/CD155" title="CD155">CD155</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Integrin" title="Integrin">Integrins</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Lymphocyte_function-associated_antigen_1" title="Lymphocyte function-associated antigen 1">LFA-1</a> (<a href="/wiki/CD11a" class="mw-redirect" title="CD11a">CD11a</a>+<a href="/wiki/CD18" class="mw-redirect" title="CD18">CD18</a>)</li> <li><a href="/wiki/Integrin_alphaXbeta2" title="Integrin alphaXbeta2">Integrin alphaXbeta2</a> (<a href="/wiki/CD11c" class="mw-redirect" title="CD11c">CD11c</a>+<a href="/wiki/CD18" class="mw-redirect" title="CD18">CD18</a>)</li> <li><a href="/wiki/Macrophage-1_antigen" title="Macrophage-1 antigen">Macrophage-1 antigen</a> (<a href="/wiki/CD11b" class="mw-redirect" title="CD11b">CD11b</a>+<a href="/wiki/CD18" class="mw-redirect" title="CD18">CD18</a>)</li> <li><a href="/wiki/VLA-4" title="VLA-4">VLA-4</a> (<a href="/wiki/CD49d" class="mw-redirect" title="CD49d">CD49d</a>+<a href="/wiki/CD29" class="mw-redirect" title="CD29">CD29</a>)</li> <li><a href="/wiki/Glycoprotein_IIb/IIIa" title="Glycoprotein IIb/IIIa">Glycoprotein IIb/IIIa</a> (<a href="/wiki/ITGA2B" class="mw-redirect" title="ITGA2B">ITGA2B</a>+<a href="/wiki/ITGB3" class="mw-redirect" title="ITGB3">ITGB3</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Cell_adhesion_molecule#Calcium-dependent" title="Cell adhesion molecule">Calcium-dependent</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Cadherin" title="Cadherin">Cadherins</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Classical</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CDH1_(gene)" class="mw-redirect" title="CDH1 (gene)">CDH1</a></li> <li><a href="/wiki/CDH2" class="mw-redirect" title="CDH2">CDH2</a></li> <li><a href="/wiki/CDH3_(gene)" title="CDH3 (gene)">CDH3</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Desmosome" title="Desmosome">Desmosomal</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Desmoglein" title="Desmoglein">Desmoglein</a> (<a href="/wiki/Desmoglein-1" title="Desmoglein-1">DSG1</a>, <a href="/wiki/Desmoglein-2" title="Desmoglein-2">DSG2</a>, <a href="/wiki/Desmoglein-3" title="Desmoglein-3">DSG3</a>, <a href="/wiki/Desmoglein-4" title="Desmoglein-4">DSG4</a>)</li> <li><a href="/wiki/Desmocollin" title="Desmocollin">Desmocollin</a> (<a href="/wiki/DSC1" title="DSC1">DSC1</a>, <a href="/wiki/DSC2" title="DSC2">DSC2</a>, <a href="/wiki/DSC3" title="DSC3">DSC3</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Protocadherin" title="Protocadherin">Protocadherin</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/PCDH1" title="PCDH1">PCDH1</a></li> <li><a href="/wiki/PCDH15" title="PCDH15">PCDH15</a></li> <li><a href="/wiki/Protocadherin_19" title="Protocadherin 19">PCDH19</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Unconventional/ungrouped</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/T-cadherin" title="T-cadherin">T-cadherin</a></li> <li><a href="/wiki/CDH4" title="CDH4">CDH4</a></li> <li><a href="/wiki/VE-cadherin" title="VE-cadherin">CDH5</a></li> <li><a href="/wiki/CDH6" title="CDH6">CDH6</a></li> <li><a href="/wiki/CDH8" title="CDH8">CDH8</a></li> <li><a href="/wiki/CDH11" title="CDH11">CDH11</a></li> <li><a href="/wiki/CDH12" title="CDH12">CDH12</a></li> <li><a href="/wiki/CDH15" title="CDH15">CDH15</a></li> <li><a href="/wiki/CDH16" title="CDH16">CDH16</a></li> <li><a href="/wiki/CDH17" title="CDH17">CDH17</a></li> <li><a href="/wiki/CDH9" title="CDH9">CDH9</a></li> <li><a href="/wiki/CDH10" title="CDH10">CDH10</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Selectin" title="Selectin">Selectins</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/E-selectin" title="E-selectin">E-selectin</a></li> <li><a href="/wiki/L-selectin" title="L-selectin">L-selectin</a></li> <li><a href="/wiki/P-selectin" title="P-selectin">P-selectin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Lymphocyte_homing_receptor" title="Lymphocyte homing receptor">Lymphocyte homing receptor</a>: <a href="/wiki/CD44" title="CD44">CD44</a></li> <li><a href="/wiki/L-selectin" title="L-selectin">L-selectin</a></li> <li><i><a href="/wiki/Integrin" title="Integrin">integrin</a></i> (<a href="/wiki/VLA-4" title="VLA-4">VLA-4</a>, <a href="/wiki/LFA-1" class="mw-redirect" title="LFA-1">LFA-1</a>)</li></ul> <ul><li><a href="/wiki/Carcinoembryonic_antigen" title="Carcinoembryonic antigen">Carcinoembryonic antigen</a></li> <li><a href="/wiki/CD24" title="CD24">CD24</a></li> <li><a href="/wiki/CD44" title="CD44">CD44</a></li> <li><a href="/wiki/CD146" title="CD146">CD146</a></li> <li><a href="/wiki/Epithelial_cell_adhesion_molecule" title="Epithelial cell adhesion molecule">EpCAM</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Cluster_of_differentiation_by_lineage" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background:#e7dcc3"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Clusters_of_differentiation_by_lineage" title="Template:Clusters of differentiation by lineage"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Clusters_of_differentiation_by_lineage" title="Template talk:Clusters of differentiation by lineage"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Clusters_of_differentiation_by_lineage" title="Special:EditPage/Template:Clusters of differentiation by lineage"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Cluster_of_differentiation_by_lineage" style="font-size:114%;margin:0 4em"><a href="/wiki/Cluster_of_differentiation" title="Cluster of differentiation">Cluster of differentiation</a> by lineage</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Lymphocyte" title="Lymphocyte">Lymphoid</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/B_cell" title="B cell">B cell</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Pre-B_cell" class="mw-redirect" title="Pre-B cell">Pre-B cell</a>: <a href="/wiki/Neprilysin" title="Neprilysin">CD10/CALLA</a></li> <li><a href="/wiki/CD79A" title="CD79A">CD79A</a></li></ul> <ul><li>mature: <a href="/wiki/CD19" title="CD19">CD19</a></li> <li><a href="/wiki/CD20" title="CD20">CD20</a></li> <li><a href="/wiki/Complement_receptor_2" title="Complement receptor 2">CD21/CR2</a></li> <li><a href="/wiki/CD23" title="CD23">CD23/FcεRII</a></li> <li><a href="/wiki/Interleukin-7_receptor" title="Interleukin-7 receptor">CD127</a></li> <li><a href="/wiki/CD40_(protein)" title="CD40 (protein)">CD40</a></li></ul> <ul><li><a href="/wiki/Plasma_cell" title="Plasma cell">plasma cell</a>: <a href="/wiki/CD38" title="CD38">CD38</a></li> <li><a href="/wiki/Syndecan_1" title="Syndecan 1">CD138</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">T/NK</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/T_cell" title="T cell">T cell</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Pan-T_antigens" title="Pan-T antigens">Pan-T antigens</a>: <a href="/wiki/CD3_(immunology)" title="CD3 (immunology)">CD3</a></li> <li><a href="/wiki/CD7" title="CD7">CD7</a></li></ul> <ul><li><a href="/wiki/CD1" title="CD1">CD1</a></li> <li><a href="/wiki/CD4" title="CD4">CD4</a></li> <li><a href="/wiki/CD8" title="CD8">CD8</a></li> <li><a href="/wiki/Alanine_aminopeptidase" title="Alanine aminopeptidase">CD13</a></li> <li><a href="/wiki/CD18" class="mw-redirect" title="CD18">CD18</a></li> <li><a href="/wiki/Dipeptidyl_peptidase-4" title="Dipeptidyl peptidase-4">CD26</a></li> <li><a href="/wiki/CD27" title="CD27">CD27</a></li> <li><a href="/wiki/CD28" title="CD28">CD28</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/NK_cell" class="mw-redirect" title="NK cell">NK cell</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CD16" title="CD16">CD16</a></li> <li><a href="/wiki/Neural_cell_adhesion_molecule" title="Neural cell adhesion molecule">CD56/NCAM</a></li> <li><a href="/wiki/CD57" class="mw-redirect" title="CD57">CD57</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">All</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CD2" title="CD2">CD2</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">All</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CD5_(protein)" title="CD5 (protein)">CD5</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Myeloid" class="mw-redirect" title="Myeloid">Myeloid</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/CFU-GM" title="CFU-GM">CFU-GM</a>/<br /><a href="/wiki/Myelomonocyte" title="Myelomonocyte">Myelomonocyte</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CD11c" class="mw-redirect" title="CD11c">CD11c</a></li> <li><a href="/wiki/CD14" title="CD14">CD14</a></li> <li><a href="/wiki/CD15" class="mw-redirect" title="CD15">CD15</a></li> <li><a class="mw-selflink selflink">CD31</a></li> <li><a href="/wiki/CD64_(biology)" title="CD64 (biology)">CD64</a></li> <li><a href="/wiki/CD68" title="CD68">CD68</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Megakaryocyte-erythroid_progenitor_cell" class="mw-redirect" title="Megakaryocyte-erythroid progenitor cell">MEP</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/CFU-Meg" title="CFU-Meg">CFU-Meg</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CD34" title="CD34">CD34</a>/<a href="/wiki/CD36" title="CD36">CD36</a></li> <li><a href="/wiki/CD42" class="mw-redirect" title="CD42">CD42</a></li> <li><a href="/wiki/CD41" class="mw-redirect" title="CD41">CD41</a>/<a href="/wiki/CD61" class="mw-redirect" title="CD61">CD61</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/CFU-E" title="CFU-E">CFU-E</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CD36" title="CD36">CD36</a></li> <li><a href="/wiki/CD71" class="mw-redirect" title="CD71">CD71</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">All (pan-myeloid)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Alanine_aminopeptidase" title="Alanine aminopeptidase">CD13</a></li> <li><a href="/wiki/CD33" title="CD33">CD33</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Hematopoietic_stem_cell" title="Hematopoietic stem cell">Stem cell</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CD34" title="CD34">CD34</a></li></ul> </div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" href="https://en.wikipedia.org/w/index.php?title=CD31&oldid=1251265368">https://en.wikipedia.org/w/index.php?title=CD31&oldid=1251265368</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Help:Category" title="Help:Category">Categories</a>: <ul><li><a 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