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illumination</title> <meta name="description" content="Search results for: tumor illumination"> <meta name="keywords" content="tumor illumination"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none 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action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="tumor illumination"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 975</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: tumor illumination</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">975</span> Targeted Photodynamic Therapy for Intraperitoneal Ovarian Cancer, A Way to Stimulate Anti-Tumoral Immune Response</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Lea%20Boidin">Lea Boidin</a>, <a href="https://publications.waset.org/abstracts/search?q=Martha%20Baydoun"> Martha Baydoun</a>, <a href="https://publications.waset.org/abstracts/search?q=Bertrand%20Leroux"> Bertrand Leroux</a>, <a href="https://publications.waset.org/abstracts/search?q=Olivier%20Morales"> Olivier Morales</a>, <a href="https://publications.waset.org/abstracts/search?q=Samir%20Acherar"> Samir Acherar</a>, <a href="https://publications.waset.org/abstracts/search?q=Celine%20Frochot"> Celine Frochot</a>, <a href="https://publications.waset.org/abstracts/search?q=Nadira%20Delhem"> Nadira Delhem</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Ovarian cancer (OC) is one of the most defying diseases in gynecologic oncology. Even though surgery remains crucial in the therapy of patients with primary ovarian cancer, recurrent recidivism calls for the development of new therapy protocols to propose for patients dealing with this cancer. FRα is described as a tumor‐associated antigen in OC, where FRα expression is usually linked with more poorly differentiated, aggressive tumors. The Photodynamic treatment (PDT) available data have shown improvements in the uptake of small tumors and in the induction of a proper anti-tumoral immune response. In order to target specifically peritoneal metastatis, which overexpress FRα, a new-patented PS coupled with folic acid has been developed in our team. Herein we propose PDT using this new patented PS for PDT applied in an in vivo mice model. The efficacy of the treatment was evaluated in mice without and with PBMC reconstitution. Mice were divided into four groups: Non-Treated, PS, Light Only, and PDT Treated and subjected to illumination by laser set at 668nm with a duration of illumination of 45 minutes (or 1 min of illumination followed by 2 minutes of pause repeated 45 times). When mice were not reconstituted and after fractionized PDT protocol, a significant decrease in the tumor volume was noticed. An induction in the anti-tumoral cytokine IFNγ chaperoned this decrease while a subsequent inhibition in the cytokine TGFβ. Even more crucial, when mice were reconstituted and upon PDT, the fold of tumor decrease was even higher. An immune response was activated decoded with an increase in NK, CD3 +, LT helper and Cytotoxic T cells. Thereafter, an increase in the expression of the cytokines IFNγ and TNFα were noticed while an inhibition in TGFβ, IL8 and IL10 accompanied this immune response activation. Therefore, our work has shown for the first time that a fractionized PDT protocol using a folate-targeted PDT is effective for treatment of ovarian cancer. The interest in using PDT in this case, goes beyond the local induction of tumor apoptosis only, but can promote subsequent anti-tumor response. Most of the therapies currently used to treat ovarian cancer, have an uncooperative outcomes on the host immune response. The readiness of a tumor adjuvant treatment like PDT adequate in eliminating the tumor and in concert stimulating anti-tumor immunity would be weighty. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=folate%20receptor" title="folate receptor">folate receptor</a>, <a href="https://publications.waset.org/abstracts/search?q=ovarian%20cancer" title=" ovarian cancer"> ovarian cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=photodynamic%20therapy" title=" photodynamic therapy"> photodynamic therapy</a>, <a href="https://publications.waset.org/abstracts/search?q=humanized%20mice%20model" title=" humanized mice model"> humanized mice model</a> </p> <a href="https://publications.waset.org/abstracts/151346/targeted-photodynamic-therapy-for-intraperitoneal-ovarian-cancer-a-way-to-stimulate-anti-tumoral-immune-response" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/151346.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">110</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">974</span> Vascular Targeted Photodynamic Therapy Monitored by Real-Time Laser Speckle Imaging</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ruth%20Goldschmidt">Ruth Goldschmidt</a>, <a href="https://publications.waset.org/abstracts/search?q=Vyacheslav%20Kalchenko"> Vyacheslav Kalchenko</a>, <a href="https://publications.waset.org/abstracts/search?q=Lilah%20Agemy"> Lilah Agemy</a>, <a href="https://publications.waset.org/abstracts/search?q=Rachel%20Elmoalem"> Rachel Elmoalem</a>, <a href="https://publications.waset.org/abstracts/search?q=Avigdor%20Scherz"> Avigdor Scherz</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Vascular Targeted Photodynamic therapy (VTP) is a new modality for selective cancer treatment that leads to the complete tumor ablation. A photosensitizer, a bacteriochlorophyll derivative in our case, is first administered to the patient and followed by the illumination of the tumor area, by a near-IR laser for its photoactivation. The photoactivated drug releases reactive oxygen species (ROS) in the circulation, which reacts with blood cells and the endothelium leading to the occlusion of the blood vasculature. If the blood vessels are only partially closed, the tumor may recover, and cancer cells could survive. On the other hand, excessive treatment may lead to toxicity of healthy tissues nearby. Simultaneous VTP monitoring and image processing independent of the photoexcitation laser has not yet been reported, to our knowledge. Here we present a method for blood flow monitoring, using a real-time laser speckle imaging (RTLSI) in the tumor during VTP. We have synthesized over the years a library of bacteriochlorophyll derivatives, among them WST11 and STL-6014. Both are water soluble derivatives that are retained in the blood vasculature through their partial binding to HSA. WST11 has been approved in Mexico for VTP treatment of prostate cancer at a certain drug dose, and time/intensity of illumination. Application to other bacteriochlorophyll derivatives or other cancers may require different treatment parameters (such as light/drug administration). VTP parameters for STL-6014 are still under study. This new derivative mainly differs from WST11 by its lack of the central Palladium, and its conjugation to an Arg-Gly-Asp (RGD) sequence. RGD is a tumor-specific ligand that is used for targeting the necrotic tumor domains through its affinity to αVβ3 integrin receptors. This enables the study of cell-targeted VTP. We developed a special RTLSI module, based on Labview software environment for data processing. The new module enables to acquire raw laser speckle images and calculate the values of the laser temporal statistics of time-integrated speckles in real time, without additional off-line processing. Using RTLSI, we could monitor the tumor’s blood flow following VTP in a CT26 colon carcinoma ear model. VTP with WST11 induced an immediate slow down of the blood flow within the tumor and a complete final flow arrest, after some sporadic reperfusions. If the irradiation continued further, the blood flow stopped also in the blood vessels of the surrounding healthy tissue. This emphasizes the significance of light dose control. Using our RTLSI system, we could prevent any additional healthy tissue damage by controlling the illumination time and restrict blood flow arrest within the tumor only. In addition, we found that VTP with STL-6014 was the most effective when the photoactivation was conducted 4h post-injection, in terms of tumor ablation success in-vivo and blood vessel flow arrest. In conclusion, RTSLI application should allow to optimize VTP efficacy vs. toxicity in both the preclinical and clinical arenas. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=blood%20vessel%20occlusion" title="blood vessel occlusion">blood vessel occlusion</a>, <a href="https://publications.waset.org/abstracts/search?q=cancer%20treatment" title=" cancer treatment"> cancer treatment</a>, <a href="https://publications.waset.org/abstracts/search?q=photodynamic%20therapy" title=" photodynamic therapy"> photodynamic therapy</a>, <a href="https://publications.waset.org/abstracts/search?q=real%20time%20imaging" title=" real time imaging"> real time imaging</a> </p> <a href="https://publications.waset.org/abstracts/71243/vascular-targeted-photodynamic-therapy-monitored-by-real-time-laser-speckle-imaging" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/71243.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">223</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">973</span> PCR Based DNA Analysis in Detecting P53 Mutation in Human Breast Cancer (MDA-468)</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Debbarma%20Asis">Debbarma Asis</a>, <a href="https://publications.waset.org/abstracts/search?q=Guha%20Chandan"> Guha Chandan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Tumor Protein-53 (P53) is one of the tumor suppressor proteins. P53 regulates the cell cycle that conserves stability by preventing genome mutation. It is named so as it runs as 53-kilodalton (kDa) protein on Polyacrylamide gel electrophoresis although the actual mass is 43.7 kDa. Experimental evidence has indicated that P53 cancer mutants loses tumor suppression activity and subsequently gain oncogenic activities to promote tumourigenesis. Tumor-specific DNA has recently been detected in the plasma of breast cancer patients. Detection of tumor-specific genetic materials in cancer patients may provide a unique and valuable tumor marker for diagnosis and prognosis. Commercially available MDA-468 breast cancer cell line was used for the proposed study. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=tumor%20protein%20%28P53%29" title="tumor protein (P53)">tumor protein (P53)</a>, <a href="https://publications.waset.org/abstracts/search?q=cancer%20mutants" title=" cancer mutants"> cancer mutants</a>, <a href="https://publications.waset.org/abstracts/search?q=MDA-468" title=" MDA-468"> MDA-468</a>, <a href="https://publications.waset.org/abstracts/search?q=tumor%20suppressor%20gene" title=" tumor suppressor gene"> tumor suppressor gene</a> </p> <a href="https://publications.waset.org/abstracts/43690/pcr-based-dna-analysis-in-detecting-p53-mutation-in-human-breast-cancer-mda-468" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/43690.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">480</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">972</span> Ultra Wideband Breast Cancer Detection by Using SAR for Indication the Tumor Location</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Wittawat%20Wasusathien">Wittawat Wasusathien</a>, <a href="https://publications.waset.org/abstracts/search?q=Samran%20Santalunai"> Samran Santalunai</a>, <a href="https://publications.waset.org/abstracts/search?q=Thanaset%20Thosdeekoraphat"> Thanaset Thosdeekoraphat</a>, <a href="https://publications.waset.org/abstracts/search?q=Chanchai%20Thongsopa"> Chanchai Thongsopa</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This paper presents breast cancer detection by observing the specific absorption rate (SAR) intensity for identification tumor location, the tumor is identified in coordinates (x,y,z) system. We examined the frequency between 4-8 GHz to look for the most appropriate frequency. Results are simulated in frequency 4-8 GHz, the model overview include normal breast with 50 mm radian, 5 mm diameter of tumor, and ultra wideband (UWB) bowtie antenna. The models are created and simulated in CST Microwave Studio. For this simulation, we changed antenna to 5 location around the breast, the tumor can be detected when an antenna is close to the tumor location, which the coordinate of maximum SAR is approximated the tumor location. For reliable, we experiment by random tumor location to 3 position in the same size of tumor and simulation the result again by varying the antenna position in 5 position again, and it also detectable the tumor position from the antenna that nearby tumor position by maximum value of SAR, which it can be detected the tumor with precision in all frequency between 4-8 GHz. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=specific%20absorption%20rate%20%28SAR%29" title="specific absorption rate (SAR)">specific absorption rate (SAR)</a>, <a href="https://publications.waset.org/abstracts/search?q=ultra%20wideband%20%28UWB%29" title=" ultra wideband (UWB)"> ultra wideband (UWB)</a>, <a href="https://publications.waset.org/abstracts/search?q=coordinates" title=" coordinates"> coordinates</a>, <a href="https://publications.waset.org/abstracts/search?q=cancer%20detection" title=" cancer detection"> cancer detection</a> </p> <a href="https://publications.waset.org/abstracts/10465/ultra-wideband-breast-cancer-detection-by-using-sar-for-indication-the-tumor-location" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/10465.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">403</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">971</span> Energy Efficient Lighting in Educational Buildings through the Example of a High School in Istanbul</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nihan%20Gurel%20Ulusan">Nihan Gurel Ulusan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> It is obvious that electrical energy, which is an inseparable part of modern day’s human and also the most important power source of our age, should be generated on a level that will suffice the nation’s requirements. The electrical energy used for a sustainable architectural design should be reduced as much as possible. Designing the buildings as energy efficient systems which aim at reducing the artificial illumination loads has been a current subject of our times as a result of concepts gaining importance like conscious consumption of energy sources, environment-friendly designs and sustainability. Reducing the consumption of electrical energy regarding the artificial lighting carries great significance, especially in the volumes which are used all day long like the educational buildings. Starting out with such an aim in this paper, the educational buildings are explored in terms of energy efficient lighting. Firstly, illumination techniques, illumination systems, light sources, luminaries, illumination controls and 'efficient energy' usage in lighting are mentioned. In addition, natural and artificial lighting systems used in educational buildings and also the spaces building up these kind buildings are examined in terms of energy efficient lighting. Lastly, the illumination properties of the school sample chosen for this study, Kağıthane Anadolu Lisesi, a typical high school in Istanbul, is observed. Suggestions are made in order to improve the system by evaluating the illumination properties of the classes with the survey carried out with the users. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=educational%20buildings" title="educational buildings">educational buildings</a>, <a href="https://publications.waset.org/abstracts/search?q=energy%20efficient" title=" energy efficient"> energy efficient</a>, <a href="https://publications.waset.org/abstracts/search?q=illumination%20techniques" title=" illumination techniques"> illumination techniques</a>, <a href="https://publications.waset.org/abstracts/search?q=lighting" title=" lighting"> lighting</a> </p> <a href="https://publications.waset.org/abstracts/64601/energy-efficient-lighting-in-educational-buildings-through-the-example-of-a-high-school-in-istanbul" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/64601.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">282</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">970</span> Optimising Light Conditions for Recombinant Protein Production in the Microalgal Chlamydomonas reinhardtii Chloroplast</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Saskya%20E.%20Carrera%20P.">Saskya E. Carrera P.</a>, <a href="https://publications.waset.org/abstracts/search?q=Ben%20Hankamer"> Ben Hankamer</a>, <a href="https://publications.waset.org/abstracts/search?q=Melanie%20Oey"> Melanie Oey</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The green alga C. reinhardtii provides a platform for the cheap, scalable, and safe production of complex proteins. Despite gene expression in photosynthetic organisms being tightly regulated by light, most expression studies have analysed chloroplast recombinant protein production under constant light. Here the influence of illumination time and intensity on GFP and a GFP-PlyGBS (bacterial-lysin) fusion protein expression was investigated. The expression of both proteins was strongly influenced by the light regime (6-24 hr illumination per day), the light intensity (0-450 E m⁻²s⁻¹) and growth condition (photoautotrophic, mixotrophic and heterotrophic). Heterotrophic conditions resulted in relatively low recombinant protein yields per unit volume, despite high protein yields per cell, due to low growth rates. Mixotrophic conditions exhibited the highest yields at 6 hrs illumination at 200µE m⁻²s⁻¹ and under continuous low light illumination (13-16 mg L⁻¹ GFP and 1.2-1.6 mg L⁻¹ GFP-PlyGBS), as these conditions supported good cell growth and cellular protein yields. A ~23-fold increase in protein accumulation per cell and ~9-fold increase L⁻¹ culture was observed compared to standard constant 24 hr illumination for GFP-PlyGBS. The highest yields under photoautotrophic conditions were obtained under 9 hrs illumination (6 mg L⁻¹ GFP and 2.1 mg L⁻¹ GFP-PlyGBS). This represents a ~4-fold increase in cellular protein accumulation for GFP-PlyGBS. On a volumetric basis the highest yield was at 15 hrs illumination (~2-fold increase L⁻¹ over the constant light for GFP-PlyGBS). Optimising illumination conditions to balance growth and protein expression can thus significantly enhance overall recombinant protein production in C. reinhardtii cultures. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=chlamydomonas%20reinhardtii" title="chlamydomonas reinhardtii">chlamydomonas reinhardtii</a>, <a href="https://publications.waset.org/abstracts/search?q=light" title=" light"> light</a>, <a href="https://publications.waset.org/abstracts/search?q=mixotrophic" title=" mixotrophic"> mixotrophic</a>, <a href="https://publications.waset.org/abstracts/search?q=recombinant%20protein" title=" recombinant protein"> recombinant protein</a> </p> <a href="https://publications.waset.org/abstracts/84908/optimising-light-conditions-for-recombinant-protein-production-in-the-microalgal-chlamydomonas-reinhardtii-chloroplast" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/84908.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">255</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">969</span> Maximizing Nitrate Absorption of Agricultural Waste Water in a Tubular Microalgae Reactor by Adapting the Illumination Spectrum</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=J.%20Martin">J. Martin</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Dannenberg"> A. Dannenberg</a>, <a href="https://publications.waset.org/abstracts/search?q=G.%20Detrell"> G. Detrell</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20Ewald"> R. Ewald</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Fasoulas"> S. Fasoulas</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Microalgae-based photobioreactors (PBR) for Life Support Systems (LSS) are currently being investigated for future space missions such as a crewed base on planets or moons. Biological components may help reducing resupply masses by closing material mass flows with the help of regenerative components. Via photosynthesis, the microalgae use CO<sub>2</sub>, water, light and nutrients to provide oxygen and biomass for the astronauts. These capabilities could have synergies with Earth applications that tackle current problems and the developed technologies can be transferred. For example, a current worldwide discussed issue is the increased nitrate and phosphate pollution of ground water from agricultural waste waters. To investigate the potential use of a biological system based on the ability of the microalgae to extract and use nitrate and phosphate for the treatment of polluted ground water from agricultural applications, a scalable test stand is being developed. This test stand investigates the maximization of intake rates of nitrate and quantifies the produced biomass and oxygen. To minimize the required energy, for the uptake of nitrate from artificial waste water (AWW) the Flashing Light Effect (FLE) and the adaption of the illumination spectrum were realized. This paper describes the composition of the AWW, the development of the illumination unit and the possibility of non-invasive process optimization and control via the adaption of the illumination spectrum and illumination cycles. The findings were a doubling of the energy related growth rate by adapting the illumination setting. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=microalgae" title="microalgae">microalgae</a>, <a href="https://publications.waset.org/abstracts/search?q=illumination" title=" illumination"> illumination</a>, <a href="https://publications.waset.org/abstracts/search?q=nitrate%20uptake" title=" nitrate uptake"> nitrate uptake</a>, <a href="https://publications.waset.org/abstracts/search?q=flashing%20light%20effect" title=" flashing light effect"> flashing light effect</a> </p> <a href="https://publications.waset.org/abstracts/117448/maximizing-nitrate-absorption-of-agricultural-waste-water-in-a-tubular-microalgae-reactor-by-adapting-the-illumination-spectrum" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/117448.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">112</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">968</span> Evaluation of Tumor-Infiltrating Lymphocytes in Breast Carcinoma: Correlation with Molecular Subtypes and Clinicopathological Parameters</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Arundhathi%20S.">Arundhathi S.</a>, <a href="https://publications.waset.org/abstracts/search?q=Poongodi%20R."> Poongodi R.</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Tumor-infiltrating lymphocytes (TILs) are indicative of the local immune response against tumor proliferation and metastasis. Emerging as a significant marker of immune reactivity, TILs are utilized to evaluate prognostic outcomes across various malignancies, including colon, ovarian, lung, bladder, and breast cancers. In breast cancer (BC), TILs are particularly relevant for assessing tumor response to therapy in both adjuvant and neoadjuvant settings, with a prominent role in triple-negative breast cancer (TNBC), where they have been associated with improved outcomes. As such, TILs are recognized as an independent marker of favorable prognosis in several tumor types, underscoring their potential as a tool in personalized cancer therapy. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=breast%20cancer" title="breast cancer">breast cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=intratumoral%20TIL" title=" intratumoral TIL"> intratumoral TIL</a>, <a href="https://publications.waset.org/abstracts/search?q=stromal%20TIL" title=" stromal TIL"> stromal TIL</a>, <a href="https://publications.waset.org/abstracts/search?q=tumor%20infiltrating%20lymphocytes" title=" tumor infiltrating lymphocytes"> tumor infiltrating lymphocytes</a> </p> <a href="https://publications.waset.org/abstracts/194529/evaluation-of-tumor-infiltrating-lymphocytes-in-breast-carcinoma-correlation-with-molecular-subtypes-and-clinicopathological-parameters" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/194529.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">8</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">967</span> MicroRNA Expression Distinguishes Neutrophil Subtypes</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=R.%20I.%20You">R. I. You</a>, <a href="https://publications.waset.org/abstracts/search?q=C.%20L.%20Ho"> C. L. Ho</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20S.%20Dai"> M. S. Dai</a>, <a href="https://publications.waset.org/abstracts/search?q=H.%20M.%20Hung"> H. M. Hung</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20F.%20Yen"> S. F. Yen</a>, <a href="https://publications.waset.org/abstracts/search?q=C.%20S.%20Chen"> C. S. Chen</a>, <a href="https://publications.waset.org/abstracts/search?q=T.%20Y.%20Chao"> T. Y. Chao</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Neutrophils are the most abundant innate immune cells to against invading microorganisms. Numerous data shown neutrophils have plasticity in response to physiological and pathological conditions. Tumor-associated neutrophils (TAN) exist in distinct types of tumor and play an important role in cancer biology. Different transcriptomic profiles of neutrophils in tumor and non-tumor samples have been identified. Several miRNAs have been recognized as regulators of gene expression in neutrophil, which may have key roles in neutrophil activation. However, the miRNAs expression patterns in TAN are not well known. To address this question, magnetic bead isolated neutrophils from tumor-bearing mice were used in this study. We analyzed production of reactive oxygen species (ROS) by luminol-dependent chemiluminescence assay. The expression of miRNAs targeting NADPH oxidase, ROS generation and autophagy was explored using quantitative real-time polymerase chain reaction. Our data suggest that tumor environment influence neutrophil develop to differential states of activation via miRNAs regulation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=tumor-associated%20neutrophil" title="tumor-associated neutrophil">tumor-associated neutrophil</a>, <a href="https://publications.waset.org/abstracts/search?q=miRNAs" title=" miRNAs"> miRNAs</a>, <a href="https://publications.waset.org/abstracts/search?q=neutrophil" title=" neutrophil"> neutrophil</a>, <a href="https://publications.waset.org/abstracts/search?q=ROS" title=" ROS "> ROS </a> </p> <a href="https://publications.waset.org/abstracts/13682/microrna-expression-distinguishes-neutrophil-subtypes" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/13682.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">470</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">966</span> Recent Advancement in Dendrimer Based Nanotechnology for the Treatment of Brain Tumor</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nitin%20Dwivedi">Nitin Dwivedi</a>, <a href="https://publications.waset.org/abstracts/search?q=Jigna%20Shah"> Jigna Shah</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Brain tumor is metastatic neoplasm of central nervous system, in most of cases it is life threatening disease with low survival rate. Despite of enormous efforts in the development of therapeutics and diagnostic tools, the treatment of brain tumors and gliomas remain a considerable challenge in the area of neuro-oncology. The most reason behind of this the presence of physiological barriers including blood brain barrier and blood brain tumor barrier, lead to insufficient reach ability of therapeutic agents at the site of tumor, result of inadequate destruction of gliomas. So there is an indeed need empowerment of brain tumor imaging for better characterization and delineation of tumors, visualization of malignant tissue during surgery, and tracking of response to chemotherapy and radiotherapy. Multifunctional different generations of dendrimer offer an improved effort for potentiate drug delivery at the site of brain tumor and gliomas. So this article emphasizes the innovative dendrimer approaches in tumor targeting, tumor imaging and delivery of therapeutic agent. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=blood%20brain%20barrier" title="blood brain barrier">blood brain barrier</a>, <a href="https://publications.waset.org/abstracts/search?q=dendrimer" title=" dendrimer"> dendrimer</a>, <a href="https://publications.waset.org/abstracts/search?q=gliomas" title=" gliomas"> gliomas</a>, <a href="https://publications.waset.org/abstracts/search?q=nanotechnology" title=" nanotechnology"> nanotechnology</a> </p> <a href="https://publications.waset.org/abstracts/30047/recent-advancement-in-dendrimer-based-nanotechnology-for-the-treatment-of-brain-tumor" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/30047.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">561</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">965</span> Computer Aided Diagnostic System for Detection and Classification of a Brain Tumor through MRI Using Level Set Based Segmentation Technique and ANN Classifier</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Atanu%20K%20Samanta">Atanu K Samanta</a>, <a href="https://publications.waset.org/abstracts/search?q=Asim%20Ali%20Khan"> Asim Ali Khan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Due to the acquisition of huge amounts of brain tumor magnetic resonance images (MRI) in clinics, it is very difficult for radiologists to manually interpret and segment these images within a reasonable span of time. Computer-aided diagnosis (CAD) systems can enhance the diagnostic capabilities of radiologists and reduce the time required for accurate diagnosis. An intelligent computer-aided technique for automatic detection of a brain tumor through MRI is presented in this paper. The technique uses the following computational methods; the Level Set for segmentation of a brain tumor from other brain parts, extraction of features from this segmented tumor portion using gray level co-occurrence Matrix (GLCM), and the Artificial Neural Network (ANN) to classify brain tumor images according to their respective types. The entire work is carried out on 50 images having five types of brain tumor. The overall classification accuracy using this method is found to be 98% which is significantly good. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=brain%20tumor" title="brain tumor">brain tumor</a>, <a href="https://publications.waset.org/abstracts/search?q=computer-aided%20diagnostic%20%28CAD%29%20system" title=" computer-aided diagnostic (CAD) system"> computer-aided diagnostic (CAD) system</a>, <a href="https://publications.waset.org/abstracts/search?q=gray-level%20co-occurrence%20matrix%20%28GLCM%29" title=" gray-level co-occurrence matrix (GLCM)"> gray-level co-occurrence matrix (GLCM)</a>, <a href="https://publications.waset.org/abstracts/search?q=tumor%20segmentation" title=" tumor segmentation"> tumor segmentation</a>, <a href="https://publications.waset.org/abstracts/search?q=level%20set%20method" title=" level set method"> level set method</a> </p> <a href="https://publications.waset.org/abstracts/61237/computer-aided-diagnostic-system-for-detection-and-classification-of-a-brain-tumor-through-mri-using-level-set-based-segmentation-technique-and-ann-classifier" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/61237.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">512</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">964</span> Synthesis of Highly Stable Near-Infrared FAPbI₃ Perovskite Doped with 5-AVA and Its Applications in NIR Light-Emitting Diodes for Bioimaging</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nasrud%20Din">Nasrud Din</a>, <a href="https://publications.waset.org/abstracts/search?q=Fawad%20Saeed"> Fawad Saeed</a>, <a href="https://publications.waset.org/abstracts/search?q=Sajid%20Hussain"> Sajid Hussain</a>, <a href="https://publications.waset.org/abstracts/search?q=Rai%20Muhammad%20Dawood%20Sultan"> Rai Muhammad Dawood Sultan</a>, <a href="https://publications.waset.org/abstracts/search?q=Premkumar%20Sellan"> Premkumar Sellan</a>, <a href="https://publications.waset.org/abstracts/search?q=Qasim%20Khan"> Qasim Khan</a>, <a href="https://publications.waset.org/abstracts/search?q=Wei%20Lei"> Wei Lei</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The continuously increasing external quantum efficiencies of Perovskite light-emitting diodes (LEDs) have received significant interest in the scientific community. The need for monitoring and medical diagnostics has experienced a steady growth in recent years, primarily caused by older people and an increasing number of heart attacks, tumors, and cancer disorders among patients. The application of Perovskite near-infrared light-emitting diode (PeNIRLEDs) has exhibited considerable efficacy in bioimaging, particularly in the visualization and examination of blood arteries, blood clots, and tumors. PeNIRLEDs exhibit exciting potential in the field of blood vessel imaging because of their advantageous attributes, including improved depth penetration and less scattering in comparison to visible light. In this study, we synthesized FAPbI₃ Perovskite doped with different concentrations of 5-Aminovaleric acid (5-AVA) 1-6 mg. The incorporation of 5-AVA as a dopant during the FAPbI₃ Perovskite formation influences the FAPbI3 Perovskite’s structural and optical properties, improving its stability, photoluminescence efficiency, and charge transport characteristics. We found a resulting PL emission peak wavelength of 850 nm and bandwidth of 44 nm, along with a calculated quantum yield of 75%. The incorporation of 5-AVA-modified FAPbI₃ Perovskite into LEDs will show promising results, enhancing device efficiency, color purity, and stability. Making it suitable for various medical applications, including subcutaneous deep vein imaging, blood flow visualization, and tumor illumination. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=perovskite%20light-emitting%20diodes" title="perovskite light-emitting diodes">perovskite light-emitting diodes</a>, <a href="https://publications.waset.org/abstracts/search?q=deep%20vein%20imaging" title=" deep vein imaging"> deep vein imaging</a>, <a href="https://publications.waset.org/abstracts/search?q=blood%20flow%20visualization" title=" blood flow visualization"> blood flow visualization</a>, <a href="https://publications.waset.org/abstracts/search?q=tumor%20illumination" title=" tumor illumination"> tumor illumination</a> </p> <a href="https://publications.waset.org/abstracts/186722/synthesis-of-highly-stable-near-infrared-fapbi3-perovskite-doped-with-5-ava-and-its-applications-in-nir-light-emitting-diodes-for-bioimaging" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/186722.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">56</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">963</span> Multi-Layer Multi-Feature Background Subtraction Using Codebook Model Framework</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yun-Tao%20Zhang">Yun-Tao Zhang</a>, <a href="https://publications.waset.org/abstracts/search?q=Jong-Yeop%20Bae"> Jong-Yeop Bae</a>, <a href="https://publications.waset.org/abstracts/search?q=Whoi-Yul%20Kim"> Whoi-Yul Kim</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background modeling and subtraction in video analysis has been widely proved to be an effective method for moving objects detection in many computer vision applications. Over the past years, a large number of approaches have been developed to tackle different types of challenges in this field. However, the dynamic background and illumination variations are two of the most frequently occurring issues in the practical situation. This paper presents a new two-layer model based on codebook algorithm incorporated with local binary pattern (LBP) texture measure, targeted for handling dynamic background and illumination variation problems. More specifically, the first layer is designed by block-based codebook combining with LBP histogram and mean values of RGB color channels. Because of the invariance of the LBP features with respect to monotonic gray-scale changes, this layer can produce block-wise detection results with considerable tolerance of illumination variations. The pixel-based codebook is employed to reinforce the precision from the outputs of the first layer which is to eliminate false positives further. As a result, the proposed approach can greatly promote the accuracy under the circumstances of dynamic background and illumination changes. Experimental results on several popular background subtraction datasets demonstrate a very competitive performance compared to previous models. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=background%20subtraction" title="background subtraction">background subtraction</a>, <a href="https://publications.waset.org/abstracts/search?q=codebook%20model" title=" codebook model"> codebook model</a>, <a href="https://publications.waset.org/abstracts/search?q=local%20binary%20pattern" title=" local binary pattern"> local binary pattern</a>, <a href="https://publications.waset.org/abstracts/search?q=dynamic%20background" title=" dynamic background"> dynamic background</a>, <a href="https://publications.waset.org/abstracts/search?q=illumination%20change" title=" illumination change"> illumination change</a> </p> <a href="https://publications.waset.org/abstracts/43011/multi-layer-multi-feature-background-subtraction-using-codebook-model-framework" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/43011.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">217</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">962</span> Mage Fusion Based Eye Tumor Detection</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ahmed%20Ashit">Ahmed Ashit</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Image fusion is a significant and efficient image processing method used for detecting different types of tumors. This method has been used as an effective combination technique for obtaining high quality images that combine anatomy and physiology of an organ. It is the main key in the huge biomedical machines for diagnosing cancer such as PET-CT machine. This thesis aims to develop an image analysis system for the detection of the eye tumor. Different image processing methods are used to extract the tumor and then mark it on the original image. The images are first smoothed using median filtering. The background of the image is subtracted, to be then added to the original, results in a brighter area of interest or tumor area. The images are adjusted in order to increase the intensity of their pixels which lead to clearer and brighter images. once the images are enhanced, the edges of the images are detected using canny operators results in a segmented image comprises only of the pupil and the tumor for the abnormal images, and the pupil only for the normal images that have no tumor. The images of normal and abnormal images are collected from two sources: “Miles Research” and “Eye Cancer”. The computerized experimental results show that the developed image fusion based eye tumor detection system is capable of detecting the eye tumor and segment it to be superimposed on the original image. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=image%20fusion" title="image fusion">image fusion</a>, <a href="https://publications.waset.org/abstracts/search?q=eye%20tumor" title=" eye tumor"> eye tumor</a>, <a href="https://publications.waset.org/abstracts/search?q=canny%20operators" title=" canny operators"> canny operators</a>, <a href="https://publications.waset.org/abstracts/search?q=superimposed" title=" superimposed"> superimposed</a> </p> <a href="https://publications.waset.org/abstracts/30750/mage-fusion-based-eye-tumor-detection" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/30750.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">363</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">961</span> Effects of Aerobic Training on MicroRNA Let-7a Expression and Levels of Tumor Tissue IL-6 in Mice With Breast Cancer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Leila%20Anoosheh">Leila Anoosheh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Aim: The aim of this study was to assess The effects of aerobic training on microRNA let-7a expression and levels of tumor tissue IL-6 in mice with breast cancer. Method: Twenty BALB/c c mice (4-5 weeks,17 gr mass) were cancerous by injection of estrogen-dependent receptor breast cancer cells MC4-L2 and divided into two groups: tumor-training(TT) and tumor-control(TC) group. Then TT group completed aerobic training for 6 weeks, 5 days per week (14-18 m/min). After tumor emersion, tumor width and length were measured by digital caliper every week. 48 hours after the last exercise subjects were killed. Tissue sampling were collected and stored in -70ᵒ. Tumor tissue was homogenized and let-7a expression and IL-6 levels were accounted with Real time-PCR and ELISA Kit respectively. Statistical analysis of let-7a was conducted by the REST software. Repeated measures and independent tests were used to assess tumor size and IL-6, respectively. Results: Tumor size and IL-6 levels were significantly decreased in TT group compare with TC group (p<0.05). microRNA let-7a was increased significantly in TT against control group respectively (p=0/000). Conclusion: Reduction in tumor size, followed by aerobic exercise can be attributed to the loss of inflammatory factors such as IL-6; It seems that regarding to up regulation effects of aerobic exercise training on let-7a and down regulation effects of that on IL-6 in mice with breast cancer, This type of training can be used as adjuvant therapy in conjunction with other therapies for breast cancer. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=breast%20cancer" title="breast cancer">breast cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=aerobic%20training" title=" aerobic training"> aerobic training</a>, <a href="https://publications.waset.org/abstracts/search?q=microRNA%20%20let-7a" title=" microRNA let-7a"> microRNA let-7a</a>, <a href="https://publications.waset.org/abstracts/search?q=IL-6" title=" IL-6"> IL-6</a> </p> <a href="https://publications.waset.org/abstracts/16519/effects-of-aerobic-training-on-microrna-let-7a-expression-and-levels-of-tumor-tissue-il-6-in-mice-with-breast-cancer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/16519.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">432</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">960</span> An Insight into Early Stage Detection of Malignant Tumor by Microwave Imaging </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Muhammad%20Hassan%20Khalil">Muhammad Hassan Khalil</a>, <a href="https://publications.waset.org/abstracts/search?q=Xu%20Jiadong"> Xu Jiadong</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Detection of malignant tumor inside the breast of women is a challenging field for the researchers. MWI (Microwave imaging) for breast cancer diagnosis has been of interest for last two decades, newly it suggested for finding cancerous tissues of women breast. A simple and basic idea of the mathematical modeling is used throughout this paper for imaging of malignant tumor. In this paper, the authors explained inverse scattering method in the microwave imaging and also present some simulation results. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=breast%20cancer%20detection" title="breast cancer detection">breast cancer detection</a>, <a href="https://publications.waset.org/abstracts/search?q=microwave%20imaging" title=" microwave imaging"> microwave imaging</a>, <a href="https://publications.waset.org/abstracts/search?q=tomography" title=" tomography"> tomography</a>, <a href="https://publications.waset.org/abstracts/search?q=tumor" title=" tumor"> tumor</a> </p> <a href="https://publications.waset.org/abstracts/2718/an-insight-into-early-stage-detection-of-malignant-tumor-by-microwave-imaging" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/2718.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">411</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">959</span> Metastatic Ovarian Tumor Discovered Accidentally during Cesarean Section in a 34 Year Old Woman: A Case Report</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ghada%20E.%20Esheba">Ghada E. Esheba</a>, <a href="https://publications.waset.org/abstracts/search?q=Ghufran%20Kheshaifaty"> Ghufran Kheshaifaty</a>, <a href="https://publications.waset.org/abstracts/search?q=Kholoud%20%20Al-Harbi"> Kholoud Al-Harbi</a>, <a href="https://publications.waset.org/abstracts/search?q=Wafa%27a%20Al-Harbi"> Wafa'a Al-Harbi</a>, <a href="https://publications.waset.org/abstracts/search?q=Ala%27a%20Al-Orabi"> Ala'a Al-Orabi</a>, <a href="https://publications.waset.org/abstracts/search?q=Moayad%20Turkistani"> Moayad Turkistani</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Krukenberg tumor is a rare metastatic ovarian carcinoma that usually occurs in female between 30 - 40 year old and rarely seen after menopause. Stomach is the most common primary site. Histopathological features of krukenberg tumors appear as diffuse stromal proliferation, mucus-production, and numerous signet-cells and these tumors spread mostly by lymphatic route. Treatment and prognostic factors are not well established. This study describes a 34 year old female with a unilateral ovarian mass discovered accidentally during cesarean section delivery and it was misdiagnosed as luteoma of pregnancy, but histopathological examination showed a diffuse infiltration of the ovary and omentum by signet ring cells. These findings were not correlated with luteoma of pregnancy or any other types of primary ovarian tumors like surface epithelial tumor, sex cord stromal tumor or germ cell tumor. However, after the analysis of immunohistochemical results (negative CK7, positive CK20 and CDX-2), the finding was the diagnostic of metastatic krukenberg tumor. Two weeks later, the patient was evaluated and a large gastric tumor was found in her stomach and she underwent gastrectomy. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=CK7" title="CK7">CK7</a>, <a href="https://publications.waset.org/abstracts/search?q=CK20" title=" CK20"> CK20</a>, <a href="https://publications.waset.org/abstracts/search?q=CDX-2" title=" CDX-2"> CDX-2</a>, <a href="https://publications.waset.org/abstracts/search?q=Krukenburg%20tumor" title=" Krukenburg tumor"> Krukenburg tumor</a>, <a href="https://publications.waset.org/abstracts/search?q=metastatic%20ovarian%20tumor" title=" metastatic ovarian tumor"> metastatic ovarian tumor</a> </p> <a href="https://publications.waset.org/abstracts/59354/metastatic-ovarian-tumor-discovered-accidentally-during-cesarean-section-in-a-34-year-old-woman-a-case-report" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/59354.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">315</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">958</span> Liver Tumor Detection by Classification through FD Enhancement of CT Image</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=N.%20Ghatwary">N. Ghatwary</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Ahmed"> A. Ahmed</a>, <a href="https://publications.waset.org/abstracts/search?q=H.%20Jalab"> H. Jalab</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this paper, an approach for the liver tumor detection in computed tomography (CT) images is represented. The detection process is based on classifying the features of target liver cell to either tumor or non-tumor. Fractional differential (FD) is applied for enhancement of Liver CT images, with the aim of enhancing texture and edge features. Later on, a fusion method is applied to merge between the various enhanced images and produce a variety of feature improvement, which will increase the accuracy of classification. Each image is divided into NxN non-overlapping blocks, to extract the desired features. Support vector machines (SVM) classifier is trained later on a supplied dataset different from the tested one. Finally, the block cells are identified whether they are classified as tumor or not. Our approach is validated on a group of patients’ CT liver tumor datasets. The experiment results demonstrated the efficiency of detection in the proposed technique. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=fractional%20differential%20%28FD%29" title="fractional differential (FD)">fractional differential (FD)</a>, <a href="https://publications.waset.org/abstracts/search?q=computed%20tomography%20%28CT%29" title=" computed tomography (CT)"> computed tomography (CT)</a>, <a href="https://publications.waset.org/abstracts/search?q=fusion" title=" fusion"> fusion</a>, <a href="https://publications.waset.org/abstracts/search?q=aplha" title=" aplha"> aplha</a>, <a href="https://publications.waset.org/abstracts/search?q=texture%20features." title=" texture features."> texture features.</a> </p> <a href="https://publications.waset.org/abstracts/39719/liver-tumor-detection-by-classification-through-fd-enhancement-of-ct-image" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/39719.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">359</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">957</span> Stability Analysis of Tumor-Immune Fractional Order Model</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sadia%20Arshad">Sadia Arshad</a>, <a href="https://publications.waset.org/abstracts/search?q=Yifa%20Tang"> Yifa Tang</a>, <a href="https://publications.waset.org/abstracts/search?q=Dumitru%20Baleanu"> Dumitru Baleanu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A fractional order mathematical model is proposed that incorporate CD8+ cells, natural killer cells, cytokines and tumor cells. The tumor cells growth in the absence of an immune response is modeled by logistic law as it was the simplest form for which predictions also agreed with the experimental data. Natural Killer Cells are our first line of defense. NK cells directly kill tumor cells through several mechanisms, including the release of cytoplasmic granules containing perforin and granzyme, expression of tumor necrosis factor (TNF) family members. The effect of the NK cells on the tumor cell population is expressed with the product term. Rational form is used to describe interaction between CD8+ cells and tumor cells. A number of cytokines are produced by NKs, including tumor necrosis factor TNF, IFN, and interleukin (IL-10). Source term for cytokines is modeled by Michaelis-Menten form to indicate the saturated effects of the immune response. Stability of the equilibrium points is discussed for biologically significant values of bifurcation parameters. We studied the treatment of fractional order system by investigating analytical conditions of tumor eradication. Numerical simulations are presented to illustrate the analytical results. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cancer%20model" title="cancer model">cancer model</a>, <a href="https://publications.waset.org/abstracts/search?q=fractional%20calculus" title=" fractional calculus"> fractional calculus</a>, <a href="https://publications.waset.org/abstracts/search?q=numerical%20simulations" title=" numerical simulations"> numerical simulations</a>, <a href="https://publications.waset.org/abstracts/search?q=stability%20analysis" title=" stability analysis"> stability analysis</a> </p> <a href="https://publications.waset.org/abstracts/52821/stability-analysis-of-tumor-immune-fractional-order-model" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/52821.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">315</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">956</span> Evaluation of Tumor Microenvironment Using Molecular Imaging</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Fakhrosadat%20Sajjadian">Fakhrosadat Sajjadian</a>, <a href="https://publications.waset.org/abstracts/search?q=Ramin%20Ghasemi%20Shayan"> Ramin Ghasemi Shayan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The tumor microenvironment plays an fundamental part in tumor start, movement, metastasis, and treatment resistance. It varies from ordinary tissue in terms of its extracellular network, vascular and lymphatic arrange, as well as physiological conditions. The clinical application of atomic cancer imaging is regularly prevented by the tall commercialization costs of focused on imaging operators as well as the constrained clinical applications and little showcase measure of a few operators. . Since numerous cancer types share comparable characteristics of the tumor microenvironment, the capacity to target these biomarkers has the potential to supply clinically translatable atomic imaging advances for numerous types encompassing cancer and broad clinical applications. Noteworthy advance has been made in focusing on the tumor microenvironment for atomic cancer imaging. In this survey, we summarize the standards and methodologies of later progresses in atomic imaging of the tumor microenvironment, utilizing distinctive imaging modalities for early discovery and conclusion of cancer. To conclude, The tumor microenvironment (TME) encompassing tumor cells could be a profoundly energetic and heterogeneous composition of safe cells, fibroblasts, forerunner cells, endothelial cells, flagging atoms and extracellular network (ECM) components. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=molecular" title="molecular">molecular</a>, <a href="https://publications.waset.org/abstracts/search?q=imaging" title=" imaging"> imaging</a>, <a href="https://publications.waset.org/abstracts/search?q=TME" title=" TME"> TME</a>, <a href="https://publications.waset.org/abstracts/search?q=medicine" title=" medicine"> medicine</a> </p> <a href="https://publications.waset.org/abstracts/182733/evaluation-of-tumor-microenvironment-using-molecular-imaging" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/182733.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">45</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">955</span> Predictive Value of Primary Tumor Depth for Cervical Lymphadenopathy in Squamous Cell Carcinoma of Buccal Mucosa</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Zohra%20Salim">Zohra Salim</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Objective: To access the relationship of primary tumor thickness with cervical lymphadenopathy in squamous cell carcinoma of buccal mucosa. Methodology: A cross-sectional observational study was carried out on 80 Patients with biopsy-proven oral squamous cell carcinoma of buccal mucosa at Dow University of Health Sciences. All the study participants were treated with wide local excision of the primary tumor with elective neck dissection. Patients with prior head and neck malignancy or those with prior radiotherapy or chemotherapy were excluded from the study. Data was entered and analyzed on SPSS 21. Chi-squared test with 95% C.I and 80% power of the test was used to evaluate the relationship of tumor depth with cervical lymph nodes. Results: 50 participants were male, and 30 patients were female. 30 patients were in the age range of 20-40 years, 36 patients in the range of 40-60 years, while 14 patients were beyond age 60 years. Tumor size ranged from 0.3cm to 5cm with a mean of 2.03cm. Tumor depth ranged from 0.2cm to 5cm. 20% of the participants reported with tumor depth greater than 2.5cm, while 80% of patients reported with tumor depth less than 2.5cm. Out of 80 patients, 27 reported with negative lymph nodes, while 53 patients reported with positive lymph nodes. Conclusion: Our study concludes that relationship exists between the depth of primary tumor and cervical lymphadenopathy in squamous cell carcinoma of buccal mucosa. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=squamous%20cell%20carcinoma" title="squamous cell carcinoma">squamous cell carcinoma</a>, <a href="https://publications.waset.org/abstracts/search?q=tumor%20depth" title=" tumor depth"> tumor depth</a>, <a href="https://publications.waset.org/abstracts/search?q=cervical%20lymphadenopathy" title=" cervical lymphadenopathy"> cervical lymphadenopathy</a>, <a href="https://publications.waset.org/abstracts/search?q=buccal%20mucosa" title=" buccal mucosa"> buccal mucosa</a> </p> <a href="https://publications.waset.org/abstracts/85223/predictive-value-of-primary-tumor-depth-for-cervical-lymphadenopathy-in-squamous-cell-carcinoma-of-buccal-mucosa" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/85223.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">237</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">954</span> Tumor Boundary Extraction Using Intensity and Texture-Based on Gradient Vector</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Namita%20Mittal">Namita Mittal</a>, <a href="https://publications.waset.org/abstracts/search?q=Himakshi%20Shekhawat"> Himakshi Shekhawat</a>, <a href="https://publications.waset.org/abstracts/search?q=Ankit%20Vidyarthi"> Ankit Vidyarthi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In medical research study, doctors and radiologists face lot of complexities in analysing the brain tumors in Magnetic Resonance (MR) images. Brain tumor detection is difficult due to amorphous tumor shape and overlapping of similar tissues in nearby region. So, radiologists require one such clinically viable solution which helps in automatic segmentation of tumor inside brain MR image. Initially, segmentation methods were used to detect tumor, by dividing the image into segments but causes loss of information. In this paper, a hybrid method is proposed which detect Region of Interest (ROI) on the basis of difference in intensity values and texture values of tumor region using nearby tissues with Gradient Vector Flow (GVF) technique in the identification of ROI. Proposed approach uses both intensity and texture values for identification of abnormal section of the brain MR images. Experimental results show that proposed method outperforms GVF method without any loss of information. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=brain%20tumor" title="brain tumor">brain tumor</a>, <a href="https://publications.waset.org/abstracts/search?q=GVF" title=" GVF"> GVF</a>, <a href="https://publications.waset.org/abstracts/search?q=intensity" title=" intensity"> intensity</a>, <a href="https://publications.waset.org/abstracts/search?q=MR%20images" title=" MR images"> MR images</a>, <a href="https://publications.waset.org/abstracts/search?q=segmentation" title=" segmentation"> segmentation</a>, <a href="https://publications.waset.org/abstracts/search?q=texture" title=" texture"> texture</a> </p> <a href="https://publications.waset.org/abstracts/22986/tumor-boundary-extraction-using-intensity-and-texture-based-on-gradient-vector" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/22986.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">432</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">953</span> A Distinct Method Based on Mamba-Unet for Brain Tumor Image Segmentation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Djallel%20Bouamama">Djallel Bouamama</a>, <a href="https://publications.waset.org/abstracts/search?q=Yasser%20R.%20Haddadi"> Yasser R. Haddadi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Accurate brain tumor segmentation is crucial for diagnosis and treatment planning, yet it remains a challenging task due to the variability in tumor shapes and intensities. This paper introduces a distinct approach to brain tumor image segmentation by leveraging an advanced architecture known as Mamba-Unet. Building on the well-established U-Net framework, Mamba-Unet incorporates distinct design enhancements to improve segmentation performance. Our proposed method integrates a multi-scale attention mechanism and a hybrid loss function to effectively capture fine-grained details and contextual information in brain MRI scans. We demonstrate that Mamba-Unet significantly enhances segmentation accuracy compared to conventional U-Net models by utilizing a comprehensive dataset of annotated brain MRI scans. Quantitative evaluations reveal that Mamba-Unet surpasses traditional U-Net architectures and other contemporary segmentation models regarding Dice coefficient, sensitivity, and specificity. The improvements are attributed to the method's ability to manage class imbalance better and resolve complex tumor boundaries. This work advances the state-of-the-art in brain tumor segmentation and holds promise for improving clinical workflows and patient outcomes through more precise and reliable tumor detection. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=brain%20tumor%20classification" title="brain tumor classification">brain tumor classification</a>, <a href="https://publications.waset.org/abstracts/search?q=image%20segmentation" title=" image segmentation"> image segmentation</a>, <a href="https://publications.waset.org/abstracts/search?q=CNN" title=" CNN"> CNN</a>, <a href="https://publications.waset.org/abstracts/search?q=U-NET" title=" U-NET"> U-NET</a> </p> <a href="https://publications.waset.org/abstracts/192073/a-distinct-method-based-on-mamba-unet-for-brain-tumor-image-segmentation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/192073.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">34</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">952</span> Identification of Functional T Cell Receptors Reactive to Tumor Antigens from the T Cell Repertoire of Healthy Donors</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Isaac%20Quiros-Fernandez">Isaac Quiros-Fernandez</a>, <a href="https://publications.waset.org/abstracts/search?q=Angel%20Cid-Arregui"> Angel Cid-Arregui</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Tumor-reactive T cell receptors (TCRs) are being subject of intense investigation since they offer great potential in adoptive cell therapies against cancer. However, the identification of tumor-specific TCRs has proven challenging, for instance, due to the limited expansion capacity of tumor-infiltrating T cells (TILs) and the extremely low frequencies of tumor-reactive T cells in the repertoire of patients and healthy donors. We have developed an approach for rapid identification and characterization of neoepitope-reactive TCRs from the T cell repertoire of healthy donors. CD8 T cells isolated from multiple donors are subjected to a first sorting step after staining with HLA multimers carrying the peptide of interest. The isolated cells are expanded for two weeks, after which a second sorting is performed using the same peptide-HLA multimers. The cells isolated in this way are then processed for single-cell sequencing of their TCR alpha and beta chains. Newly identified TCRs are cloned in appropriate expression vectors for functional analysis on Jurkat, NK92, and primary CD8 T cells and tumor cells expressing the appropriate antigen. We have identified TCRs specifically binding HLA-A2 presenting epitopes of tumor antigens, which are capable of inducing TCR-mediated cell activation and cytotoxicity in target cancer cell lines. This method allows the identification of tumor-reactive TCRs in about two to three weeks, starting from peripheral blood samples of readily available healthy donors. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cancer" title="cancer">cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=TCR" title=" TCR"> TCR</a>, <a href="https://publications.waset.org/abstracts/search?q=tumor%20antigens" title=" tumor antigens"> tumor antigens</a>, <a href="https://publications.waset.org/abstracts/search?q=immunotherapy" title=" immunotherapy"> immunotherapy</a> </p> <a href="https://publications.waset.org/abstracts/153990/identification-of-functional-t-cell-receptors-reactive-to-tumor-antigens-from-the-t-cell-repertoire-of-healthy-donors" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/153990.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">69</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">951</span> Effects of a Bioactive Subfraction of Strobilanthes Crispus on the Tumour Growth, Body Weight and Haematological Parameters in 4T1-Induced Breast Cancer Model</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yusha%27u%20Shu%27aibu%20Baraya">Yusha'u Shu'aibu Baraya</a>, <a href="https://publications.waset.org/abstracts/search?q=Kah%20Keng%20%20Wong"> Kah Keng Wong</a>, <a href="https://publications.waset.org/abstracts/search?q=Nik%20Soriani%20Yaacob"> Nik Soriani Yaacob</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Strobilanthes crispus (S. crispus), is a Malaysian herb locally known as ‘Pecah kaca’ or ‘Jin batu’ which have demonstrated potent anticancer effects in both in vitro and in vivo models. In particular, S. crispus subfraction (SCS) significantly reduced tumor growth in N-methyl-N-Nitrosourea-induced breast cancer rat model. However, there is paucity of information on the effects of SCS in breast cancer metastasis. Thus, in this study, the antimetastatic effects of SCS (100 mg/kg) was investigated following 30 days of treatment in 4T1-induced mammary tumor (n = 5) model. The response to treatment was assessed based on the outcome of the tumour growth, body weight and hematological parameters. The results demonstrated that tumor bearing mice treated with SCS (TM-S) had significant (p<0.05) reduction in the mean tumor number and tumor volume as well as tumor weight compared to the tumor bearing mice (TM), i.e. tumor untreated group. Also, there was no secondary tumor formation or tumor-associated lesions in the major organs of TM-S compared to the TM group. Similarly, comparable body weights were observed among the TM-S, normal (uninduced) mice treated with SCS and normal (untreated/control) mice (NM) groups compared to the TM group (p<0.05). Furthermore, SCS administration does not cause significant changes in the hematological parameters as compared to the NM group, which indicates no sign of anemia and toxicity related effects. In conclusion, SCS significantly inhibited the overall tumor growth and metastasis in 4T1-induced breast cancer mouse model suggesting its promising potentials as therapeutic agent for breast cancer treatment. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=4T1-cells" title="4T1-cells">4T1-cells</a>, <a href="https://publications.waset.org/abstracts/search?q=breast%20cancer" title=" breast cancer"> breast cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=metastasis" title=" metastasis"> metastasis</a>, <a href="https://publications.waset.org/abstracts/search?q=Strobilanthes%20crispus" title=" Strobilanthes crispus "> Strobilanthes crispus </a> </p> <a href="https://publications.waset.org/abstracts/119710/effects-of-a-bioactive-subfraction-of-strobilanthes-crispus-on-the-tumour-growth-body-weight-and-haematological-parameters-in-4t1-induced-breast-cancer-model" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/119710.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">152</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">950</span> Drug Delivery to Solid Tumor: Effect of Dynamic Capillary Network Induced by Tumor</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mostafa%20Sefidgar">Mostafa Sefidgar</a>, <a href="https://publications.waset.org/abstracts/search?q=Kaamran%20Raahemifar"> Kaamran Raahemifar</a>, <a href="https://publications.waset.org/abstracts/search?q=Hossein%20Bazmara"> Hossein Bazmara</a>, <a href="https://publications.waset.org/abstracts/search?q=Madjid%20Soltani"> Madjid Soltani</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The computational methods provide condition for investigation related to the process of drug delivery, such as convection and diffusion of drug in extracellular matrices, and drug extravasation from microvascular. The information of this process clarifies the mechanisms of drug delivery from the injection site to absorption by a solid tumor. In this study, an advanced numerical method is used to solve fluid flow and solute transport equations simultaneously to show how capillary network structure induced by tumor affects drug delivery. The effect of heterogeneous capillary network induced by tumor on interstitial fluid flow and drug delivery is investigated by this multi scale method. The sprouting angiogenesis model is used for generating capillary network induced by tumor. Fluid flow governing equations are implemented to calculate blood flow through the tumor-induced capillary network and fluid flow in normal and tumor tissues. The Starling’s law is used for closing this system of equations and coupling the intravascular and extravascular flows. Finally, convection-diffusion-reaction equation is used to simulate drug delivery. The dynamic approach which changes the capillary network structure based on signals sent by hemodynamic and metabolic stimuli is used in this study for more realistic assumption. The study indicates that drug delivery to solid tumors depends on the tumor induced capillary network structure. The dynamic approach generates the irregular capillary network around the tumor and predicts a higher interstitial pressure in the tumor region. This elevated interstitial pressure with irregular capillary network leads to a heterogeneous distribution of drug in the tumor region similar to in vivo observations. The investigation indicates that the drug transport properties have a significant role against the physiological barrier of drug delivery to a solid tumor. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=solid%20tumor" title="solid tumor">solid tumor</a>, <a href="https://publications.waset.org/abstracts/search?q=physiological%20barriers%20to%20drug%20delivery" title=" physiological barriers to drug delivery"> physiological barriers to drug delivery</a>, <a href="https://publications.waset.org/abstracts/search?q=angiogenesis" title=" angiogenesis"> angiogenesis</a>, <a href="https://publications.waset.org/abstracts/search?q=microvascular%20network" title=" microvascular network"> microvascular network</a>, <a href="https://publications.waset.org/abstracts/search?q=solute%20transport" title=" solute transport"> solute transport</a> </p> <a href="https://publications.waset.org/abstracts/37128/drug-delivery-to-solid-tumor-effect-of-dynamic-capillary-network-induced-by-tumor" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/37128.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">312</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">949</span> MSIpred: A Python 2 Package for the Classification of Tumor Microsatellite Instability from Tumor Mutation Annotation Data Using a Support Vector Machine</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Chen%20Wang">Chen Wang</a>, <a href="https://publications.waset.org/abstracts/search?q=Chun%20Liang"> Chun Liang</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Microsatellite instability (MSI) is characterized by high degree of polymorphism in microsatellite (MS) length due to a deficiency in mismatch repair (MMR) system. MSI is associated with several tumor types and its status can be considered as an important indicator for tumor prognostic. Conventional clinical diagnosis of MSI examines PCR products of a panel of MS markers using electrophoresis (MSI-PCR) which is laborious, time consuming, and less reliable. MSIpred, a python 2 package for automatic classification of MSI was released by this study. It computes important somatic mutation features from files in mutation annotation format (MAF) generated from paired tumor-normal exome sequencing data, subsequently using these to predict tumor MSI status with a support vector machine (SVM) classifier trained by MAF files of 1074 tumors belonging to four types. Evaluation of MSIpred on an independent 358-tumor test set achieved overall accuracy of over 98% and area under receiver operating characteristic (ROC) curve of 0.967. These results indicated that MSIpred is a robust pan-cancer MSI classification tool and can serve as a complementary diagnostic to MSI-PCR in MSI diagnosis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=microsatellite%20instability" title="microsatellite instability">microsatellite instability</a>, <a href="https://publications.waset.org/abstracts/search?q=pan-cancer%20classification" title=" pan-cancer classification"> pan-cancer classification</a>, <a href="https://publications.waset.org/abstracts/search?q=somatic%20mutation" title=" somatic mutation"> somatic mutation</a>, <a href="https://publications.waset.org/abstracts/search?q=support%20vector%20machine" title=" support vector machine"> support vector machine</a> </p> <a href="https://publications.waset.org/abstracts/93236/msipred-a-python-2-package-for-the-classification-of-tumor-microsatellite-instability-from-tumor-mutation-annotation-data-using-a-support-vector-machine" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/93236.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">173</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">948</span> Collision Tumor of Plasmacytoma with Hematological and Non-Hematological Malignancies</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Arati%20Inamdar">Arati Inamdar</a>, <a href="https://publications.waset.org/abstracts/search?q=Siddharth%20Bhattacharyya"> Siddharth Bhattacharyya</a>, <a href="https://publications.waset.org/abstracts/search?q=Kester%20Haye"> Kester Haye</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Collision tumors are rare entities characterized by neoplasms of two different cell populations with distinct separating boundaries. Such tumors could be benign, malignant, or a combination of both. The exact mechanism of origin for collision tumors is predicted to be tumor heterogeneity or concurrent occurrence of neoplasm in the same organ. We present two cases of plasmacytoma presenting as a collision tumor, one with a tumor of hematological origin and another with a non-hematological origin, namely Chronic Lymphocytic Leukemia and Adenocarcinoma of the colon, respectively. The immunohistochemical stains and flowcytometry analysis performed on the specimens aided incorrect diagnosis. Interestingly, neoplastic cells of plasmacytoma in the first case demonstrated strong cytokeratin along with weak Epithelial Specific Antigen/ Epithelial cell adhesion molecule Monoclonal Antibody (MOC31) positivity, indicating that the tumor may influence the microenvironment of the tumor in the vicinity. Furthermore, the next-generation sequencing studies performed on the specimen with plasmacytoma and chronic lymphocytic lymphoma demonstrated BReast CAncer gene (BRCA2) and Tumor Necrosis Factor Alpha Induced Protein 3 (TNFAIP3) as a disease associated variants suggestive of risk for multiple tumors including collision tumors. Our reports highlight the unique collision tumors involving plasmacytoma, which have never been reported previously, as well as provide necessary insights about the underline genetic aberrations and tumor heterogeneity through sequencing studies and allow clonality assessment for subsequent tumors. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=BRCA2" title="BRCA2">BRCA2</a>, <a href="https://publications.waset.org/abstracts/search?q=collision%20tumor" title=" collision tumor"> collision tumor</a>, <a href="https://publications.waset.org/abstracts/search?q=chronic%20lymphocytic%20leukemia" title=" chronic lymphocytic leukemia"> chronic lymphocytic leukemia</a>, <a href="https://publications.waset.org/abstracts/search?q=plasmacytoma" title=" plasmacytoma"> plasmacytoma</a> </p> <a href="https://publications.waset.org/abstracts/162721/collision-tumor-of-plasmacytoma-with-hematological-and-non-hematological-malignancies" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/162721.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">190</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">947</span> Development and Characterization of Site Specific Peptide Conjugated Polymeric Nanoparticles for Efficient Delivery of Paclitaxel</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Madhu%20Gupta">Madhu Gupta</a>, <a href="https://publications.waset.org/abstracts/search?q=Vikas%20Sharma"> Vikas Sharma</a>, <a href="https://publications.waset.org/abstracts/search?q=Suresh%20P.%20Vyas"> Suresh P. Vyas</a> </p> <p class="card-text"><strong>Abstract:</strong></p> CD13 receptors are abundantly overexpressed in tumor cells as well as in neovasculature. The CD13 receptors were selected as a targeted site and polymeric nanoparticles (NPs) as a targeted delivery system. By combining these, a cyclic NGR (cNGR) peptide ligand was coupled on the terminal end of polyethylene glycol-b-poly(lactic-co-glycolic acid) (PEG-b-PLGA) and prepared the dual targeted-NPs (cNGR-PEG-PTX-NPs) to enhance the intracellular delivery of anticancer drug to tumor cells and tumor endothelial cells via ligand-receptor interaction. In-vitro cytotoxicity studies confirmed that the presence of cNGR enhanced the cytotoxic efficiency by 2.8 folds in Human Umbilical Vein Endothelial (HUVEC) cells, while cytotoxicity was improved by 2.6 folds in human fibrosarcoma (HT-1080) cells as compared to non-specific stealth NPs. Compared with other tested NPs, cNGR-PEG-PTX-NPs revealed more cytotoxicity by inducing more apoptosis and higher intracellular uptake. The tumor volume inhibition rate was 59.7% in case of cNGR-PEG-PTX-NPs that was comparatively more with other formulations, indicating that cNGR-PEG-PTX-NPs could more effectively inhibit tumor growth. As a consequence, the cNGR-PEG-PTX-NPs play a key role in enhancing tumor therapeutic efficiency for treatment of CD13 receptor specific solid tumor. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cyclic%20NGR" title="cyclic NGR">cyclic NGR</a>, <a href="https://publications.waset.org/abstracts/search?q=CD13%20receptor" title=" CD13 receptor"> CD13 receptor</a>, <a href="https://publications.waset.org/abstracts/search?q=targeted%20polymeric%20NPs" title=" targeted polymeric NPs"> targeted polymeric NPs</a>, <a href="https://publications.waset.org/abstracts/search?q=solid%20tumor" title=" solid tumor"> solid tumor</a>, <a href="https://publications.waset.org/abstracts/search?q=intracellular%20delivery" title=" intracellular delivery "> intracellular delivery </a> </p> <a href="https://publications.waset.org/abstracts/30544/development-and-characterization-of-site-specific-peptide-conjugated-polymeric-nanoparticles-for-efficient-delivery-of-paclitaxel" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/30544.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">437</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">946</span> Synthesis of Mesoporous In₂O₃-TiO₂ Nanocomposites as Efficient Photocatalyst for Treatment Industrial Wastewater under Visible Light and UV Illumination</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ibrahim%20%20Abdelfattah">Ibrahim Abdelfattah</a>, <a href="https://publications.waset.org/abstracts/search?q=Adel%20%20Ismail"> Adel Ismail</a>, <a href="https://publications.waset.org/abstracts/search?q=Ahmed%20%20Helal"> Ahmed Helal</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohamed%20%20Faisal"> Mohamed Faisal</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Advanced oxidation technologies are an environment friendly approach for the remediation of industrial wastewaters. Here, one pot synthesis of mesoporous In₂O₃-TiO₂ nanocomposites at different In₂O₃ contents (0-3 wt%) have been synthesized through a facile sol-gel method to evaluate their photocatalytic performance for the degradation of the imazapyr herbicide and phenol under visible light and UV illumination compared with commercially available either Degussa P-25 or UV-100 Hombikat. The prepared mesoporous In₂O₃-TiO₂ nanocomposites were characterized by TEM, STEM, XRD, Raman FT-IR, Raman spectra and diffuse reflectance UV-visible. The bandgap energy of the prepared photocatalysts was derived from the diffuse reflectance spectra. XRD Raman's spectra confirmed that highly crystalline anatase TiO₂ phase was formed. TEM images show TiO₂ particles are quite uniform with 10±2 nm sizes with mesoporous structure. The mesoporous TiO₂ exhibits large pore volumes of 0.267 cm³g⁻¹ and high surface areas of 178 m²g⁻¹, but they become reduced to 0.211 cm³g⁻¹ and 112 m²g⁻¹, respectively upon In₂O₃ incorporation, with tunable mesopore diameter in the range of 5 - 7 nm. The 0.5% In₂O₃-TiO₂ nanocomposite is considered to be the optimum photocatalyst which is able to degrade 90% of imazapyr herbicide and phenol along 180 min and 60 min respectively. The proposed mechanism of this system and the role of In₂O₃ are explained by details. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=In%E2%82%82O%E2%82%83-TiO%E2%82%82%20nanocomposites" title="In₂O₃-TiO₂ nanocomposites">In₂O₃-TiO₂ nanocomposites</a>, <a href="https://publications.waset.org/abstracts/search?q=sol-gel%20method" title=" sol-gel method"> sol-gel method</a>, <a href="https://publications.waset.org/abstracts/search?q=visible%20light%20illumination" title=" visible light illumination"> visible light illumination</a>, <a href="https://publications.waset.org/abstracts/search?q=UV%20illumination" title=" UV illumination"> UV illumination</a>, <a href="https://publications.waset.org/abstracts/search?q=herbicide%20and%20phenol%20wastewater" title=" herbicide and phenol wastewater"> herbicide and phenol wastewater</a>, <a href="https://publications.waset.org/abstracts/search?q=removal" title=" removal"> removal</a> </p> <a href="https://publications.waset.org/abstracts/61850/synthesis-of-mesoporous-in2o3-tio2-nanocomposites-as-efficient-photocatalyst-for-treatment-industrial-wastewater-under-visible-light-and-uv-illumination" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/61850.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">297</span> </span> </div> </div> <ul class="pagination"> <li class="page-item disabled"><span class="page-link">&lsaquo;</span></li> <li class="page-item active"><span class="page-link">1</span></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=tumor%20illumination&page=2">2</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=tumor%20illumination&page=3">3</a></li> <li class="page-item"><a class="page-link" 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