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{"work":{"id":12857209,"created_at":"2015-06-08T00:33:55.428-07:00","from_world_paper_id":137389620,"updated_at":"2024-11-18T13:30:47.882-08:00","_data":{"grobid_abstract":"Air pollutants (AP) play a role in subclinical inflammation, and are associated with cardiovascular morbidity and mortality. Metabolic syndrome (MetS) is inflammatory and precedes cardiovascular morbidity and type 2 diabetes. Thus, a positive association between AP and MetS may be hypothesized. We explored this association, (taking into account, pathwayspecific MetS definitions), and its potential modifiers in Swiss adults. We studied 3769 participants of the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults, reporting at least four-hour fasting time before venepuncture. AP exposures were 10-year mean residential PM 10 (particulate matter \u003c10μm in diameter) and NO 2 (nitrogen dioxide). Outcomes included MetS defined by World Health Organization (MetS-W), International Diabetes Federation (MetS-I) and Adult Treatment Panel-III (MetS-A) using four-and eighthour fasting time limits. We also explored associations with individual components of MetS. We applied mixed logistic regression models to explore these associations. The prevalence of MetS-W, MetS-I and MetS-A were 10%, 22% and 18% respectively. Odds of MetS-W, MetS-I and MetS-A increased by 72% (51-102%), 31% (11-54%) and 18% (4-34%) per 10μg/m 3 increase in 10-year mean PM 10 . We observed weaker associations with NO 2 . Associations were stronger among physically-active, ever-smokers and non-diabetic participants especially with PM 10 (p\u003c0.05). Associations remained robust across various sensitivity analyses including ten imputations of missing observations and exclusion of diabetes cases. The observed associations between AP exposure and MetS were sensitive to MetS definitions. Regarding the MetS components, we observed strongest associations with impaired fasting glycemia, and positive but weaker associations with hypertension and waist-circumference-based obesity. Cardio-metabolic effects of AP may be majorly driven by impairment of glucose homeostasis, and to a less-strong extent, visceral adiposity. Welldesigned prospective studies are needed to confirm these findings.","publication_date":"2011,,","publication_name":"PLoS ONE","grobid_abstract_attachment_id":"45887150"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Long-Term Exposure to Ambient Air Pollution and Mortality Due to Cardiovascular Disease and Cerebrovascular Disease in Shenyang, China","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [31976424,31999659,32071134,32826726]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div 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Harkema</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Environmental Health Perspectives, 2013</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Cardiovascular Depression in Rats Exposed to Inhaled Particulate Matter and Ozone: Effects of Diet-Induced Metabolic Syndrome","attachmentId":66009573,"attachmentType":"pdf","work_url":"https://www.academia.edu/45523098/Cardiovascular_Depression_in_Rats_Exposed_to_Inhaled_Particulate_Matter_and_Ozone_Effects_of_Diet_Induced_Metabolic_Syndrome","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/45523098/Cardiovascular_Depression_in_Rats_Exposed_to_Inhaled_Particulate_Matter_and_Ozone_Effects_of_Diet_Induced_Metabolic_Syndrome"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="13892719" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/13892719/Long_term_air_pollution_exposure_and_diabetes_in_a_population_based_Swiss_cohort">Long-term air pollution exposure and diabetes in a population-based Swiss cohort</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32964893" href="https://unibas.academia.edu/ChristianSchindler">Christian Schindler</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Environment international, 2014</p><p class="ds-related-work--abstract ds2-5-body-sm">Air pollution is an important risk factor for global burden of disease. There has been recent interest in its possible role in the etiology of diabetes mellitus. Experimental evidence is suggestive, but epidemiological evidence is limited and mixed. We therefore explored the association between air pollution and prevalent diabetes, in a population-based Swiss cohort. We did cross-sectional analyses of 6392 participants of the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults [SAPALDIA], aged between 29 and 73 years. We used estimates of average individual home outdoor PM10 [particulate matter &lt;10μm in diameter] and NO2 [nitrogen dioxide] exposure over the 10 years preceding the survey. Their association with diabetes was modeled using mixed logistic regression models, including participants&#39; study area as random effect, with incremental adjustment for confounders. There were 315 cases of diabetes (prevalence: 5.5% [95% confidence interval (CI): 2.8, 7....</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Long-term air pollution exposure and diabetes in a population-based Swiss cohort","attachmentId":44830363,"attachmentType":"pdf","work_url":"https://www.academia.edu/13892719/Long_term_air_pollution_exposure_and_diabetes_in_a_population_based_Swiss_cohort","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/13892719/Long_term_air_pollution_exposure_and_diabetes_in_a_population_based_Swiss_cohort"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="120613638" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/120613638/Association_of_physical_activity_and_air_pollution_exposure_with_the_risk_of_type_2_diabetes_a_large_population_based_prospective_cohort_study">Association of physical activity and air pollution exposure with the risk of type 2 diabetes: a large population-based prospective cohort study</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="297277692" href="https://independent.academia.edu/XiruZhang1">Xiru Zhang</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Environmental Health, 2022</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Association of physical activity and air pollution exposure with the risk of type 2 diabetes: a large population-based prospective cohort study","attachmentId":115706815,"attachmentType":"pdf","work_url":"https://www.academia.edu/120613638/Association_of_physical_activity_and_air_pollution_exposure_with_the_risk_of_type_2_diabetes_a_large_population_based_prospective_cohort_study","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/120613638/Association_of_physical_activity_and_air_pollution_exposure_with_the_risk_of_type_2_diabetes_a_large_population_based_prospective_cohort_study"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="103183966" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/103183966/Extreme_Air_Pollution_Conditions_Adversely_Affect_Blood_Pressure_and_Insulin_Resistance_The_Air_Pollution_and_Cardiometabolic_Disease_Study">Extreme Air Pollution Conditions Adversely Affect Blood Pressure and Insulin Resistance: The Air Pollution and Cardiometabolic Disease Study</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="6873583" href="https://independent.academia.edu/Yanpingruan">Yanping ruan</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Hypertension, 2015</p><p class="ds-related-work--abstract ds2-5-body-sm">Mounting evidence supports that fine particulate matter adversely affects cardiometabolic diseases particularly in susceptible individuals; however, health effects induced by the extreme concentrations within megacities in Asia are not well described. We enrolled 65 nonsmoking adults with metabolic syndrome and insulin resistance in the Beijing metropolitan area into a panel study of 4 repeated visits across 4 seasons since 2012. Daily ambient fine particulate matter and personal black carbon levels ranged from 9.0 to 552.5 µg/m(3) and 0.2 to 24.5 µg/m(3), respectively, with extreme levels observed during January 2013. Cumulative fine particulate matter exposure windows across the prior 1 to 7 days were significantly associated with systolic blood pressure elevations ranging from 2.0 (95% confidence interval, 0.3-3.7) to 2.7 (0.6-4.8) mm Hg per SD increase (67.2 µg/m(3)), whereas cumulative black carbon exposure during the previous 2 to 5 days were significantly associated with rang...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Extreme Air Pollution Conditions Adversely Affect Blood Pressure and Insulin Resistance: The Air Pollution and Cardiometabolic Disease Study","attachmentId":103257776,"attachmentType":"pdf","work_url":"https://www.academia.edu/103183966/Extreme_Air_Pollution_Conditions_Adversely_Affect_Blood_Pressure_and_Insulin_Resistance_The_Air_Pollution_and_Cardiometabolic_Disease_Study","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/103183966/Extreme_Air_Pollution_Conditions_Adversely_Affect_Blood_Pressure_and_Insulin_Resistance_The_Air_Pollution_and_Cardiometabolic_Disease_Study"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="52355724" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/52355724/Functional_and_metabolic_burden_of_air_pollution_relevance_of_early_disease_prediabetes_stage_for_progression_to_overt_diabetes_mellitus">Functional and metabolic burden of air pollution: relevance of early disease (prediabetes) stage for progression to overt diabetes mellitus</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="48496117" href="https://independent.academia.edu/EricBalti">Eric Balti</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Public Health and Emergency</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Functional and metabolic burden of air pollution: relevance of early disease (prediabetes) stage for progression to overt diabetes mellitus","attachmentId":69658323,"attachmentType":"pdf","work_url":"https://www.academia.edu/52355724/Functional_and_metabolic_burden_of_air_pollution_relevance_of_early_disease_prediabetes_stage_for_progression_to_overt_diabetes_mellitus","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/52355724/Functional_and_metabolic_burden_of_air_pollution_relevance_of_early_disease_prediabetes_stage_for_progression_to_overt_diabetes_mellitus"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="17862647" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/17862647/Reduced_metabolic_insulin_sensitivity_following_sub_acute_exposures_to_low_levels_of_ambient_fine_particulate_matter_air_pollution">Reduced metabolic insulin sensitivity following sub-acute exposures to low levels of ambient fine particulate matter air pollution</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33122897" href="https://umich.academia.edu/NikoKaciroti">Niko Kaciroti</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Science of The Total Environment, 2013</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Reduced metabolic insulin sensitivity following sub-acute exposures to low levels of ambient fine particulate matter air 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You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="60991367" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/60991367/Association_between_traffic_related_air_pollution_subclinical_inflammation_and_impaired_glucose_metabolism_Results_from_the_SALIA_study">Association between traffic-related air pollution, subclinical inflammation and impaired glucose metabolism: Results from the SALIA study</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="171914031" href="https://tu-dresden.academia.edu/TomTeichert">Tom 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href="https://www.academia.edu/60991367/Association_between_traffic_related_air_pollution_subclinical_inflammation_and_impaired_glucose_metabolism_Results_from_the_SALIA_study"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="1" data-entity-id="92133849" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/92133849/Physical_activity_attenuated_association_of_air_pollution_with_estimated_10_year_atherosclerotic_cardiovascular_disease_risk_in_a_large_rural_Chinese_adult_population_A_cross_sectional_study">Physical activity attenuated association of air pollution with estimated 10-year atherosclerotic cardiovascular disease risk in a large rural Chinese adult population: A 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study","attachmentId":95224709,"attachmentType":"pdf","work_url":"https://www.academia.edu/92133849/Physical_activity_attenuated_association_of_air_pollution_with_estimated_10_year_atherosclerotic_cardiovascular_disease_risk_in_a_large_rural_Chinese_adult_population_A_cross_sectional_study","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/92133849/Physical_activity_attenuated_association_of_air_pollution_with_estimated_10_year_atherosclerotic_cardiovascular_disease_risk_in_a_large_rural_Chinese_adult_population_A_cross_sectional_study"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="2" data-entity-id="17930436" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/17930436/Particulate_Air_Pollution_Metabolic_Syndrome_and_Heart_Rate_Variability_The_Multi_Ethnic_Study_of_Atherosclerosis_MESA_">Particulate Air Pollution, Metabolic Syndrome, and Heart Rate Variability: The Multi-Ethnic Study of Atherosclerosis (MESA)</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="37842117" href="https://independent.academia.edu/RonaldPrineas">Ronald Prineas</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Particulate Air Pollution, Metabolic Syndrome, and Heart Rate Variability: The Multi-Ethnic Study of Atherosclerosis (MESA)","attachmentId":39784964,"attachmentType":"pdf","work_url":"https://www.academia.edu/17930436/Particulate_Air_Pollution_Metabolic_Syndrome_and_Heart_Rate_Variability_The_Multi_Ethnic_Study_of_Atherosclerosis_MESA_","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/17930436/Particulate_Air_Pollution_Metabolic_Syndrome_and_Heart_Rate_Variability_The_Multi_Ethnic_Study_of_Atherosclerosis_MESA_"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" 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data-collection-position="9" data-entity-id="104603434" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/104603434/Metabolic_Syndrome_and_Air_Pollution_A_Narrative_Review_of_Their_Cardiopulmonary_Effects">Metabolic Syndrome and Air Pollution: A Narrative Review of Their Cardiopulmonary Effects</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="10409046" href="https://independent.academia.edu/DeanOstrofsky">Dean Ostrofsky</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Toxics, 2019</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Metabolic Syndrome and Air Pollution: A Narrative Review of Their Cardiopulmonary 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