ACIVICIN

<!DOCTYPE html> <html xmlns="http://www.w3.org/1999/xhtml" xml:lang="en" lang="en" ng-app ="ginas"> <head> <base href='/'> <meta charset="utf-8"> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta name="viewport" content="width=device-width, initial-scale=0.5"> <meta property="og:type" content="website" /> <meta property="og:url" content="https://drugs.ncats.io/substance/O0X60K76I6" /> <meta name="twitter:domain" value="drugs.ncats.io" /> <meta name="twitter:url" value="https://drugs.ncats.io/substance/O0X60K76I6" /> <meta name="twitter:card" content="summary_large_image"> <meta property="og:title" content="NCATS Inxight Drugs — ACIVICIN" /> <meta name="twitter:title" value="NCATS Inxight Drugs — ACIVICIN" /> <meta property="og:description" content="Chemical" /> <meta name="twitter:description" value="chemical" /> <meta property="og:image" content=' /img/ad53e0ba-0b16-4d7c-9e82-259b6a2e7796.png?size=500&version=11 ' /> <meta name="twitter:image" content=' /img/ad53e0ba-0b16-4d7c-9e82-259b6a2e7796.png?size=500&version=11 ' /> <meta name="twitter:label1" value="UNII" /> <meta name="twitter:data1" value="O0X60K76I6" /> <meta name="twitter:label2" value="Development Status" /> <meta name="twitter:data2" value="Possibly Marketed Outside US" />   <title>ACIVICIN</title> <link rel="icon" type="img/ico" href='/assets/ginas/images/ncats_favicon.ico'> <link rel="stylesheet" href='/webjars/bootstrap/3.3.7/css/bootstrap.min.css'> <link rel="stylesheet" href='/webjars/font-awesome/4.5.0/css/font-awesome.min.css'> <link rel="stylesheet" href='/assets/ginas/css/ng-tags-input.css'> <link rel="stylesheet" href='/assets/ginas/css/ng-tags-input.bootstrap.css'> <link rel="stylesheet" href='/assets/ginas/css/json-formatter.css'> <link rel="stylesheet" href='/assets/ginas/css/ginas.css'> <link rel="stylesheet" href='/assets/ginas/css/drugs.css'> <link rel="stylesheet" href="https://unpkg.com/flickity@2/dist/flickity.min.css"> <script src='/webjars/jquery/1.11.1/jquery.min.js'></script> <script src='/webjars/momentjs/2.11.0/moment.js'></script> <script src='/webjars/later/1.2.0/later.min.js'></script> <script src='/webjars/prettycron/0.10.0/prettycron.js'></script> <script src='/webjars/humanize-duration/3.0.0/humanize-duration.js'></script> <script src='/webjars/bootstrap/3.3.7/js/bootstrap.min.js'></script> <script src='/webjars/angularjs/1.5.7/angular.js'></script> <script src='/webjars/angular-ui-bootstrap/1.3.3/ui-bootstrap-tpls.js'></script> <script src='/webjars/angularjs/1.5.7/angular-messages.js'></script> <script src='/webjars/angularjs/1.5.7/angular-route.js'></script> <script src='/webjars/angularjs/1.5.7/angular-resource.js'></script> <script src='/webjars/angularjs/1.5.7/angular-aria.js'></script> <script src='/webjars/lodash/4.0.0/lodash.js'></script> <script src='/assets/ginas/js/angular-local-storage.js' type='text/javascript'></script> <script src='/assets/ginas/js/ginasApp.js' type='text/javascript'></script> <script src='/assets/ginas/js/ginas-admin.js' type='text/javascript'></script> <script src='/assets/ginas/js/ginas-downloads.js' type='text/javascript'></script> <script src='/assets/ginas/js/ginas-scheduled.js' type='text/javascript'></script> <script src='/assets/ginas/js/ginas-filter.js' type='text/javascript'></script> <script src='/assets/ginas/js/ginas-forms.js' type='text/javascript'></script> <script src='/assets/ginas/js/ginas-form-elements.js' type='text/javascript'></script> <script src='/assets/ginas/js/ginas-filter.js' type='text/javascript'></script> <script src='/assets/ginas/js/angular-bootstrap-file-field.js' type='text/javascript'></script> <script src='/assets/ginas/js/showErrors.js' type='text/javascript'></script> <script src='/assets/ginas/js/diff_match_patch.js' type='text/javascript'></script> <script src='/assets/ginas/js/angular-diff-match-patch.js' type='text/javascript'></script> <script src='/assets/ginas/js/angular-loading-spinner.js' type='text/javascript'></script> <script src='/assets/ginas/js/filter-listener-service.js' type='text/javascript'></script> <script src='/assets/ginas/js/validators.js' type='text/javascript'></script> <script src='/assets/ginas/js/json-formatter.js' type='text/javascript'></script> <script src='/assets/ginas/js/ng-tags-input.js' type='text/javascript'></script> <script src='/assets/ginas/js/screengrabber.js' type='text/javascript'></script> <script src='/assets/ginas/js/filereader.js' type='text/javascript'></script> <script src="https://code.highcharts.com/5.0.14/highcharts.js"></script> <script src="https://code.highcharts.com/5.0.14/modules/exporting.js"></script> <script src='https://unpkg.com/flickity@2/dist/flickity.pkgd.min.js'></script> <script type="text/javascript"> var session = { username:null }; var baseurl = '/'; console.log(baseurl); </script> <link rel="stylesheet" href='//cdn.datatables.net/1.10.15/css/jquery.dataTables.min.css'> <script src='//cdn.datatables.net/1.10.15/js/jquery.dataTables.min.js'></script>  <script async src="https://www.googletagmanager.com/gtag/js?id=G-NM44TYRR6L"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-NM44TYRR6L'); </script> <script src='/assets/ginas/js/css_browser_selector.js' type="text/javascript"></script> </head> <body scroll-spy="breadcrumb" data-target="#breadcrumb" ng-controller ="GinasController as GinasCtrl"> <div id="ncatsRibbon"> <div class="container no-gutter"> <img src="/assets/images/nihribbon-hhs.svg" alt="HHS Logo" class="ncats-ribbon hhs-logo"> <a href="http://www.hhs.gov/" title="U.S. Department of Health & Human Services | Homepage" class="ext" target="_blank">U.S. Department of Health & Human Services</a> <img src="/assets/images/nihribbon-divider.svg" class="nihDivider ncats-ribbon" alt="Divider Arrow"> <img src="/assets/images/nih-ribbon.svg" class="nihArrows ncats-ribbon nih-logo" alt="NIH Logo"> <a href="http://www.nih.gov/" title="National Institutes of Health | Homepage" class="ext" target="_blank">National Institutes of Health</a> <img src="/assets/images/nihribbon-divider.svg" class="nihDivider ncats-ribbon" alt="Divider Arrow"> <img src="/assets/images/nih-ribbon.svg" class="nihArrows ncats-ribbon nih-logo" alt="NIH Logo"> <a href="http://www.ncats.nih.gov" title="National Center for Advancing Translational Sciences | Homepage" target="new">NCATS</a> </div>  </div> <div class="row-fluid" id="main-menu">  <nav class="navbar navbar-default" role="navigation" id="menu"> <div class="container"> <div class="navbar-header"> <span class="navbar-brand navbar-nav"> <a href="/" title="Return Home" target="_self" alt ="Home" aria-label="Return Home" ng-class="(!showsearch)?'':'hidden-sm hidden-xs'" > <img src='/assets/ginas/images/ncats-logo.svg' alt="ncats logo" class="ncats-logo img-responsive hidden-xs hidden-sm" > <img src='/assets/ginas/images/ncats-logo-short.svg' alt="ncats logo" class="ncats-logo img-responsive hidden-md hidden-lg hidden-xl" > <span class="sr-only">Return Home</span> <span class="logo-header">Inxight</span> <span class="logo-header subsection">Drugs</span> </a> </span> </div> <div class="navbar-default" id="menubar"> <ul class="nav navbar-nav pull-right" id = "left-menu"> <li ng-class="(showsearch)?'':'hidden-sm hidden-xs'" ng-controller="TypeAheadController"> <div ng-cloak ="" ng-show="loadingSuggest" id="loading-suggest"> <i class="fa fa-refresh fa-spin fa-fw"></i> </div> <form class="form-inline main-search" role="search" id="main-menu-search"> <div class="input-group" id = "search-bar"> <input type="text" class="form-control" id="search" aria-label="Search Substances" title="Search Substances in Inxight Drugs" placeholder= "Search Substances..." ng-model = "query" typeahead-popup-template-url='/assets/templates/elements/suggest-popup.html' uib-typeahead="r.d as r.d for r in getSuggestions($viewValue)" typeahead-on-select="onSelect($item, $model, $label)" typeahead-loading="loadingSuggest" typeahead-focus-first ="false" autocomplete="off"> <span class="input-group-btn"> <div class="btn-group search-btn" uib-dropdown> <button id="split-button-main" class="btn btn-default" type="search" aria-label="Search Substances" ng-click = "submitq(query,'/principals')"> <span class="sr-only">Search Substances</span> <span class="fa fa-search"></span> </button> </div> </span> </div> </form> </li> <li class="hidden-xl hidden-lg hidden-md"> <a class="loupe" ng-click="showsearch=!showsearch; showclose=!showclose" ng-class="(!showclose)?'':'hidden-sm hidden-xs'"> <i class="fa fa-search" aria-hidden="true"></i> </a> </li> <li class="hidden-xl hidden-lg hidden-md"> <a class="close-loupe" ng-class="(showclose)?'':'hidden-sm hidden-xs'" ng-click="showclose=!showclose; showsearch=!showsearch"> <i class="fa fa-times-circle" aria-hidden="true"></i> </a> </li> </ul> </div> </div> <div class="container" id="h-menu"> <div ng-class="(!showsearchHMenu)?'':'hidden-sm hidden-xs'" class="col-xs-10 col-sm-11 col-md-9 col-lg-7 nopadding" id="hmenu-butt-wrap"> <ul class="nav navbar-nav"> <li class="active"> <a href="/" title="Return Home" target="_self" alt ="Home" aria-label="Return Home"> <span class="hidden-xs hidden-sm">Home</span> <i class="fa fa-lg fa-home hidden-md hidden-lg hidden-xl"></i> </a> </li> <li class="dropdown"> <a href="" data-toggle="dropdown" class="dropdown-toggle" aria-expanded="false" title="Drugs by Development Status..."> <span class="hidden-xs hidden-sm">Browse Drugs</span> <i class="fa fa-lg fa-list-ol hidden-md hidden-lg hidden-xl"></i> <i class="fa fa-caret-down"></i> </a> <ul class="dropdown-menu"> <li> <a target="_self" href="/drugs" title="US Approved Drugs"> <span>US Approved Drugs</span> </a> </li> <li> <a target="_self" href="/marketeds" title="Drugs Marketed Somewhere in the World"> <span>Marketed Drugs</span> </a> </li> <li> <a target="_self" href="/clinicals" title="Investigational Drugs"> <span>Investigational Drugs</span> </a> </li> <li> <a target="_self" href="/substances" title="All Substances"> <span>All Substances</span> </a> </li> </ul> </li> <li class="dropdown"> <a href="" data-toggle="dropdown" class="dropdown-toggle" aria-expanded="false" title="Advanced Search..."> <span class="hidden-xs hidden-sm">Search <i class="fa fa-plus-circle"></i></span> <i class="fa fa-lg fa-search-plus hidden-md hidden-lg hidden-xl"></i> <i class="fa fa-caret-down"></i> </a> <ul class="dropdown-menu"> <li> <a ng-href="/structure" ng-click="clearStructure()" target="_self" title="Search by Structure"> <span>Structure Search</span> </a> </li> <li> <a ng-href="/sequence" ng-click="clearStructure()" target="_self" title="Search by Sequence"> <span>Sequence Search</span> </a> </li> </ul> </li> <li> <a ng-href="/downloads-public" target="_self" title="Public Downloads"> <span class="hidden-xs hidden-sm">Downloads</span> <i class="fa fa-lg fa-download hidden-md hidden-lg hidden-xl"></i> </a> </li> <li> <a ng-href="/about" target="_self" title="About NCATS Inxight Drugs"> <span class="hidden-xs hidden-sm">About</span> <i class="fa fa-lg fa-question-circle hidden-md hidden-lg hidden-xl"></i> </a> </li> </ul> </div> <div class="col-md-3 col-lg-5 nopadding" id="menubar"> <ul class="nav navbar-nav pull-right"> <li ng-class="(showsearchHMenu)?'':'hidden-sm hidden-xs'" ng-controller="TypeAheadController" id="hmenu-li-search-wrap"> <div ng-cloak ="" ng-show="loadingSuggestHMenu" id="loading-suggest"> <i class="fa fa-refresh fa-spin fa-fw"></i> </div> <form class="form-inline main-search" role="search" id="main-menu-search"> <div class="input-group" id = "search-bar"> <input type="text" class="form-control" id="search" aria-label="Search Substances" title="Search Substances in Inxight Drugs" placeholder= "Search Substances..." ng-model = "query" typeahead-popup-template-url='/assets/templates/elements/suggest-popup.html' uib-typeahead="r.d as r.d for r in getSuggestions($viewValue)" typeahead-on-select="onSelect($item, $model, $label)" typeahead-loading="loadingSuggestHMenu" typeahead-focus-first ="false" autocomplete="off"> <span class="input-group-btn"> <div class="btn-group search-btn" uib-dropdown> <button id="split-button-main" class="btn btn-default" type="search" aria-label="Search Substances" ng-click = "submitq(query,'/substances')"> <span class="sr-only">Search Substances</span> <span class="fa fa-search"></span> </button> </div> </span> </div> </form> </li> <li class="hidden-xl hidden-lg hidden-md"> <a class="loupe" ng-click="showsearchHMenu=!showsearchHMenu; showcloseHMenu=!showcloseHMenu" ng-class="(!showcloseHMenu)?'':'hidden-sm hidden-xs'"> <i class="fa fa-search" aria-hidden="true"></i> </a> </li> <li class="hidden-xl hidden-lg hidden-md"> <a class="close-loupe" ng-class="(showcloseHMenu)?'':'hidden-sm hidden-xs'" ng-click="showcloseHMenu=!showcloseHMenu; showsearchHMenu=!showsearchHMenu"> <i class="fa fa-times-circle" aria-hidden="true"></i> </a> </li> </ul> </div> </div> </nav> </div> <div class="container" id="content" > <div class ="fixedpos"> <div class = "container"> <div class = "row"> <div class = "col-lg-3 hidden-xs hidden-sm hidden-md sidebar"> <div ng-cloak class="fade-ng-cloak ng-cloak sidebar-inner"> <div id="sidebar-menu-header"> <div id="sidebar-substance-name"> ACIVICIN </div> <div id="sidebar-substance-unii"> O0X60K76I6 </div> <div id="sidebar-devstatus" class="sidebar-substance-status flexbox"> <span id="icon-status" class="flexbox"> <i class="fa fa-usd" aria-hidden="true"></i> </span> <span id="label-status" title='Possibly Marketed Outside US'> Possibly Marketed Outside US </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> Acivicin by ZYF Pharm Chemical </div> <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://archive.org/details/Pharmaceutical_Manufacturing_Encyclopedia_Vols_12_2nd_Ed">https://archive.org/details/Pharmaceutical_Manufacturing_Encyclopedia_Vols_12_2nd_Ed</a> </div> </div> </info-popup> </div> <div class="sidebar-substance-status flexbox"> </div> </div> <nav id="breadcrumb"> <ul class="nav nav-pills nav-stacked" id="breadcrumb-list"> <li role="presentation" id="sidebar-menu-item"> <a href="#structure" prevent-default="" ng-click="parent.scrollTo('structure')"> <table> <tr> <td id="sidebar-menu-item-name"> Structure </td> <td id="sidebar-menu-item-count"> </td> </tr> </table> </a> <div id="sidebar-menu-separator"> </div> </li> <li role="presentation" id="sidebar-menu-item"> <a href="#moieties" prevent-default="" ng-click="parent.scrollTo('moieties')"> <table> <tr> <td id="sidebar-menu-item-name"> Moieties </td> <td id="sidebar-menu-item-count"> <span class="badge pull-right">1</span> </td> </tr> </table> </a> <div id="sidebar-menu-separator"> </div> </li> <li role="presentation" id="sidebar-menu-item"> <a href="#general" prevent-default="" ng-click="parent.scrollTo('general')"> <table> <tr> <td id="sidebar-menu-item-name"> General </td> <td id="sidebar-menu-item-count"> </td> </tr> </table> </a> <div id="sidebar-menu-separator"> </div> </li> <li role="presentation" id="sidebar-menu-item"> <a href="#activity" prevent-default="" ng-click="parent.scrollTo('activity')"> <table> <tr> <td id="sidebar-menu-item-name"> Activity </td> <td id="sidebar-menu-item-count"> </td> </tr> </table> </a> <div id="sidebar-menu-separator"> </div> </li> <li role="presentation" id="sidebar-menu-item"> <a href="#adverseevents" prevent-default="" ng-click="parent.scrollTo('adverseevents')"> <table> <tr> <td id="sidebar-menu-item-name"> Adverse Events </td> <td id="sidebar-menu-item-count"> </td> </tr> </table> </a> <div id="sidebar-menu-separator"> </div> </li> <li role="presentation" id="sidebar-menu-item"> <a href="#dditox" prevent-default="" ng-click="parent.scrollTo('dditox')"> <table> <tr> <td id="sidebar-menu-item-name"> DDI & Tox </td> <td id="sidebar-menu-item-count"> </td> </tr> </table> </a> <div id="sidebar-menu-separator"> </div> </li> <li role="presentation" id="sidebar-menu-item"> <a href="#publications" prevent-default="" ng-click="parent.scrollTo('publications')"> <table> <tr> <td id="sidebar-menu-item-name"> Publications </td> <td id="sidebar-menu-item-count"> </td> </tr> </table> </a> <div id="sidebar-menu-separator"> </div> </li> <li role="presentation" id="sidebar-menu-item"> <a href="#application" prevent-default="" ng-click="parent.scrollTo('application')"> <table> <tr> <td id="sidebar-menu-item-name"> Application </td> <td id="sidebar-menu-item-count"> </td> </tr> </table> </a> <div id="sidebar-menu-separator"> </div> </li> <li role="presentation" id="sidebar-menu-item"> <a href="#details" prevent-default="" ng-click="parent.scrollTo('details')"> <table> <tr> <td id="sidebar-menu-item-name"> Record Details </td> <td id="sidebar-menu-item-count"> </td> </tr> </table> </a> <div id="sidebar-menu-separator"> </div> </li> <li role="presentation" id="sidebar-menu-item"> <a href="#names" prevent-default="" ng-click="parent.scrollTo('names')"> <table> <tr> <td id="sidebar-menu-item-name"> Names </td> <td id="sidebar-menu-item-count"> <span class="badge pull-right">14</span> </td> </tr> </table> </a> <div id="sidebar-menu-separator"> </div> </li> <li role="presentation" id="sidebar-menu-item"> <a href="#classification" prevent-default="" ng-click="parent.scrollTo('classification')"> <table> <tr> <td id="sidebar-menu-item-name"> Classification </td> <td id="sidebar-menu-item-count"> <span class="badge pull-right">1</span> </td> </tr> </table> </a> <div id="sidebar-menu-separator"> </div> </li> <li role="presentation" id="sidebar-menu-item"> <a href="#identifiers" prevent-default="" ng-click="parent.scrollTo('identifiers')"> <table> <tr> <td id="sidebar-menu-item-name"> Identifiers </td> <td id="sidebar-menu-item-count"> <span class="badge pull-right">13</span> </td> </tr> </table> </a> <div id="sidebar-menu-separator"> </div> </li> <li role="presentation" id="sidebar-menu-item"> <a href="#activemoieties" prevent-default="" ng-click="parent.scrollTo('activemoieties')"> <table> <tr> <td id="sidebar-menu-item-name"> Active Moiety </td> <td id="sidebar-menu-item-count"> <span class="badge pull-right">1</span> </td> </tr> </table> </a> <div id="sidebar-menu-separator"> </div> </li> </ul> </nav> </div> </div> </div> </div> </div> <div class = "row"> <div class = "col-lg-9 col-md-12 col-sm-12 col-lg-offset-3"> <div ng-cloak class="fade-ng-cloak ng-cloak hidden-lg"> <div id="substance-detail-header"> <div id="sidebar-substance-name"> ACIVICIN </div> <div id="sidebar-substance-unii"> O0X60K76I6 </div> <div id="sidebar-devstatus" class="sidebar-substance-status flexbox"> <span id="icon-status" class="flexbox"> <i class="fa fa-usd" aria-hidden="true"></i> </span> <span id="label-status" title='Possibly Marketed Outside US'> Possibly Marketed Outside US </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> Acivicin by ZYF Pharm Chemical </div> <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://archive.org/details/Pharmaceutical_Manufacturing_Encyclopedia_Vols_12_2nd_Ed">https://archive.org/details/Pharmaceutical_Manufacturing_Encyclopedia_Vols_12_2nd_Ed</a> </div> </div> </info-popup> </div> <div class="sidebar-substance-status flexbox"> </div> </div> </div> <div ng-cloak class="fade-ng-cloak ng-cloak"> <card eid='structure' card-title='Structure' count='0' audit='audit'> <div class="col-md-5 col-sm-5 col-xs-5"> <div class="panel panel-default additional"> <div class="panel-heading"> <h3 class="panel-title flexbox"> Details <info-popup class="flexbox"> <div class="info-popup-container"> <div> <referencesmanager reftable hide-header="false" show='["typ","tags","cit"]' substance ="'55be1968-94cc-4e6a-a098-7ebaae1a6645'" sreferences = "[{"id":null,"label":"GInAS Reference","term":"76016778-3459-437a-b6ef-86230842e425","href":null,"_matchContext":null},{"id":null,"label":"GInAS Reference","term":"a4806e9f-77b1-4975-9f99-f4c326aaa275","href":null,"_matchContext":null},{"id":null,"label":"GInAS Reference","term":"33582c0e-7dbd-4c71-9ba9-edba8a31faf9","href":null,"_matchContext":null}]" > </referencesmanager> </div> </div> </info-popup> </h3> </div> <div class="table-responsive"> <table class="table kv-table" id="moiety-table"> <tr> <td> <span>Stereochemistry</span> </td> <td> <span class="badge" id="badge-absolute"> ABSOLUTE </span> </td> </tr> <tr> <td><span>Molecular Formula</span></td> <td class="monospace">C5H7ClN2O3</td> </tr> <tr> <td><span>Molecular Weight</span></td> <td class="monospace">178.574</td> </tr> <tr> <td><span>Optical Activity</span></td> <td><span class="badge"> UNSPECIFIED </span></td> </tr> <tr> <td><span>Defined Stereocenters</span></td> <td><span class="badge">2 / 2</span></td> </tr> <tr> <td><span>E/Z Centers</span></td> <td><span class="badge">0</span></td> </tr> <tr> <td><span>Charge</span></td> <td><span class="badge">0</span></td> </tr> </table> </div> </div> <a href="#" class="show-smiles-inchi btn btn-url font-monospace"> <br> <span class="smiles-inchi">SHOW SMILES / InChI</span><i class="fa fa-caret-down" aria-hidden="true"></i> </a> </div> <div class="col-md-6 col-sm-6 col-xs-6"> <div class = "row"> <img class="struc-thumb img-responsive" alt="Structure of ACIVICIN" title="Structure of ACIVICIN" ng-init="showStereo=false" ng-src='/img/ad53e0ba-0b16-4d7c-9e82-259b6a2e7796.svg?size=400&version=11&stereo={{showStereo}}'> <button ng-click="showStereo=!showStereo" class="btn btn-url font-monospace" ng-hide="showStereo"> <span>SHOW STEREO...</span> </button> <button ng-click="showStereo=!showStereo" class="btn btn-url font-monospace" ng-show="showStereo"> <span>HIDE STEREO...</span> </button> </div> </div> <div class="col-md-1 col-sm-1 col-xs-1"> <div class = "row"> <ul class= "tools list-unstyled"> <li class = "padded"> <modal-button type= "export" structureid ="'ad53e0ba-0b16-4d7c-9e82-259b6a2e7796'" format="mol" format2="sdf" > </modal-button> </li> <li class = "padded"> <a ng-href="/structure?q=ad53e0ba-0b16-4d7c-9e82-259b6a2e7796" tooltip-placement="auto right" uib-tooltip="Structure Search" target="_self" aria-label="Structure Search"> <span class="sr-only">Structure Search</span> <span class="fa fa-search success"></span> </a> </li> </ul> </div> </div> <div class="col-md-12 col-sm-12 col-xs-12" id="smiles-inchi"> <div class="panel panel-default additional"> <div class="panel-heading"> <h3 class="panel-title"> SMILES </h3> </div> <div class="panel-body additional-data"> <div class="monospace"> [H][C@]1(CC(Cl)=NO1)[C@H](N)C(O)=O </div> </div> </div> <div class="panel panel-default additional"> <div class="panel-heading"> <h3 class="panel-title"> InChI </h3> </div> <div class="panel-body additional-data"> <div class="monospace"> InChIKey=QAWIHIJWNYOLBE-OKKQSCSOSA-N </div> </div> <div class="panel-body additional-data"> <div class="monospace"> InChI=1S/C5H7ClN2O3/c6-3-1-2(11-8-3)4(7)5(9)10/h2,4H,1,7H2,(H,9,10)/t2-,4-/m0/s1 </div> </div> </div> <a href="#" class="hide-smiles-inchi btn btn-url font-monospace"> <br> <span class="smiles-inchi">HIDE SMILES / InChI</span><i class="fa fa-caret-up" aria-hidden="true"></i> </a> </div> </card> </div> <div ng-cloak class="fade-ng-cloak ng-cloak"> <card eid='moieties' card-title='Moieties' count='1' audit='audit'> <div class ="row"> <hr id="additional-details-separator"> <div class="col-md-4"> <rendered id= '8d8c1cfe-76dc-4e57-b0f4-3fd62f7abdda' size ="300"> </rendered> </div> <div class ="col-md-8"> <div class = "row"> <div class = "col-md-12"> <div class="col-md-6"> <div class="table-responsive"> <table class="table kv-table" id="moiety-table"> <tr> <td> <span>Molecular Formula</span> </td> <td class="monospace"> C5H7ClN2O3 </td> </tr> <tr> <td><span>Molecular Weight</span></td> <td class="monospace">178.574</td> </tr> <tr> <td> <span>Charge</span> </td> <td> <span class="badge">0</span> </td> </tr> <tr> <td><span>Count</span></td> <td class="url"> <amount value="{"uuid":"46d8d896-fae4-4a6c-b9ec-7b906451bd9c","created":1702653352000,"createdBy":"admin","lastEdited":1702653352000,"lastEditedBy":"admin","deprecated":false,"type":"MOL RATIO","average":1.0,"highLimit":null,"high":null,"lowLimit":null,"low":null,"units":"MOL RATIO","nonNumericValue":null,"approvalID":null,"references":[],"access":[],"_self":null,"_matchContext":null}"> </amount> </td> </tr> </table> </div> </div> <div class="col-md-6"> <div class="table-responsive"> <table class="table kv-table" id="moiety-table"> <tr> <td> <span>Stereochemistry</span> </td> <td> <span class="badge">ABSOLUTE</span> </td> </tr> <tr> <td> <span>Additional Stereochemistry</span> </td> <td> <span class="badge">No</span> </td> </tr> <tr> <td> <span>Defined Stereocenters</span> </td> <td> <span class="badge">2 / 2</span> </td> </tr> <tr> <td> <span>E/Z Centers</span> </td> <td> <span class="badge">0</span> </td> </tr> <tr> <td><span>Optical Activity</span></td> <td> <span class="badge"> UNSPECIFIED </span> </td> </tr> </table> </div> </div> </div> </div> </div> </div> <hr id="additional-details-separator"></card> </div> <div ng-cloak class="fade-ng-cloak ng-cloak"> <card eid='general' card-title='General' count='0' audit='audit'><div class="col-md-12"> <div class="panel panel-default additional"> <div class="panel-heading"> <h3 class="panel-title flexbox"> Description<info-popup><div class='info-popup-container'><div><span class='pop-sub-key '>Sources:&nbsp</span><span class='pop-sub-val'><span class='ext-link'><a target='_self' href='https://www.ncbi.nlm.nih.gov/pubmed/9829740'>https://www.ncbi.nlm.nih.gov/pubmed/9829740</a></span></span></div><div><span class='pop-sub-key '>Curator's Comment:&nbsp</span><span class='pop-sub-val'>The description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/24411479 | https://www.ncbi.nlm.nih.gov/pubmed/8192104 | https://www.ncbi.nlm.nih.gov/pubmed/29032155 | https://www.ncbi.nlm.nih.gov/pubmed/2173394 | https://www.ncbi.nlm.nih.gov/pubmed/3530455 |</span></div></div></info-popup><a class='info-rancho' data-toggle="popover" data-animation="true" data-placement="top" data-trigger="click focus" data-html="true" data-original-title="" title="" data-content="<span>Manually Curated </span>"><i class="fa fa-shield"></i></a> </h3> </div> <div class="panel-body additional-data"> <div class='text-block'>Acivicin is a modified amino acid and structural analog of glutamine, that irreversibly inhibits glutamine-dependent amidotransferases involved in nucleotide and amino acid biosynthesis. Acivicin is a potent antitumor agent that induces apoptosis in human lymphoblastoid cells. Phase I dose-escalating studies conducted in cancer patients administered acivicin showed reversible, dose-limiting CNS toxicity, characterized by lethargy, confusion and decreased mental status.</div> </div> </div> </div><div class="col-md-12"> <div class="panel panel-default additional"> <div class="panel-heading"> <h3 class="panel-title flexbox"> CNS Activity </h3> </div> <div class="panel-body additional-data"> <div id='one-line'><div class='fval'><div class='facet-val'><a title='CNS Active' class="label label-primary loader" target='_self' ng-href="/substances?facet=CNS Activity%2FCNS Active"><div class='facet-val-text'>CNS Active</div></a></div></div><info-popup><div class='info-popup-container'><div><span class='pop-sub-key '>Sources:&nbsp</span><span class='pop-sub-val'><span class='ext-link'><a target='_self' href='https://www.ncbi.nlm.nih.gov/pubmed/9829740'>https://www.ncbi.nlm.nih.gov/pubmed/9829740</a></span></span></div></div></info-popup><a class='info-rancho' data-toggle="popover" data-animation="true" data-placement="top" data-trigger="click focus" data-html="true" data-original-title="" title="" data-content="<span>Manually Curated </span>"><i class="fa fa-shield"></i></a></div> </div> </div> </div><div class="col-md-4"> <div class="panel panel-default additional"> <div class="panel-heading"> <h3 class="panel-title flexbox"> Originator </h3> </div> <div class="panel-body additional-data"> <div id='one-line'><div class='fval'><div class='facet-val'><a title='Hanka, L.J.|Martin, D.G.|Neil, G.L.' class="label label-primary loader" target='_self' ng-href="/substances?facet=Originator%2FHanka, L.J.|Martin, D.G.|Neil, G.L."><div class='facet-val-text'>Hanka, L.J.|Martin, D.G.|Neil, G.L.</div></a></div></div><info-popup><div class='info-popup-container'><div><span class='pop-sub-key '>Sources:&nbsp</span><span class='pop-sub-val'><span class='ext-link'>Cancer Chemotherapy Reports, Part 1 (1973), 57, (2), 141-7.</span></span></div></div></info-popup><a class='info-rancho' data-toggle="popover" data-animation="true" data-placement="top" data-trigger="click focus" data-html="true" data-original-title="" title="" data-content="<span>Manually Curated </span>"><i class="fa fa-shield"></i></a></div> </div> </div> </div><div class="col-md-4"> <div class="panel panel-default additional"> <div class="panel-heading"> <h3 class="panel-title flexbox"> Approval Year </h3> </div> <div class="panel-body additional-data"> <div class='fval'><div class='facet-val'><a title='Unknown' class="label label-primary loader" target='_self' ng-href="/substances?facet=Approval Year%2FUnknown"><div class='facet-val-text'>Unknown</div></a></div></div> </div> </div> </div></card> </div> <div ng-cloak class="fade-ng-cloak ng-cloak"> <card eid='activity' card-title='Activity' count='0' audit='audit'><div ng-init="tabActive=0" class="col-md-12 rancho-datatable"><input style='display:none;' type='number' id='tabActive' ng-model='tabActive'><uib-tabset active='tabActive'><uib-tab ng-click='hashChange("tabActive:0")' index='0'><uib-tab-heading >Targets<a class='info-rancho' data-toggle="popover" data-animation="true" data-placement="top" data-trigger="click focus" data-html="true" data-original-title="" title="" data-content="<span>Manually Curated </span>"><i class="fa fa-shield"></i></a></uib-tab-heading><div class="col-md-12"> <div class="panel panel-default additional"> <div class="panel-heading"> <h3 class="panel-title flexbox"> Targets </h3> </div> <div class="panel-body additional-data"> <table class="tabtab" ><thead><th>Primary Target</th><th>Pharmacology</th><th>Condition</th><th>Potency</th></thead><tbody><tr class='gamma-glutamyltranspeptidase_1 ' valign='top'> <td><div id='one-line'><div class='inline-middle'><div class='fval'><div class='facet-val'><a title='Gamma-glutamyltranspeptidase 1' class="label label-primary loader" target='_self' ng-href="/substances?facet=Primary Target%2FGamma-glutamyltranspeptidase 1"><div class='facet-val-text'>Gamma-glutamyltranspeptidase 1</div></a></div></div></div><info-popup><div class='info-popup-container'><div><span class='pop-sub-key '>Target ID:&nbsp</span><span class='pop-sub-val'>CHEMBL5696</span></div><div><span class='pop-sub-key '>Sources:&nbsp</span><span class='pop-sub-val'><span class='ext-link'><a target='_self' href='https://www.ncbi.nlm.nih.gov/pubmed/24411479'>https://www.ncbi.nlm.nih.gov/pubmed/24411479</a></span></span></div></div></info-popup></div></td> <td><div class='fval'><div class='facet-val'><a title='Inhibitor' class="label label-primary loader" target='_self' ng-href="/substances?facet=Pharmacology%2FInhibitor"><div class='facet-val-text'>Inhibitor</div></a></div></div></td> <td></td> <td></td> </tr></tbody></table> </div> </div> </div></uib-tab><uib-tab ng-click='hashChange("tabActive:1")' index='1'><uib-tab-heading >Conditions<a class='info-rancho' data-toggle="popover" data-animation="true" data-placement="top" data-trigger="click focus" data-html="true" data-original-title="" title="" data-content="<span>Manually Curated </span>"><i class="fa fa-shield"></i></a></uib-tab-heading><div class="col-md-12"> <div class="panel panel-default additional"> <div class="panel-heading"> <h3 class="panel-title flexbox"> Conditions </h3> </div> <div class="panel-body additional-data"> <table class="tabtab" ><thead><th>Condition</th><th>Modality</th><th>Targets</th><th>Highest Phase</th><th>Product</th></thead><tbody><tr class='solid_tumors ' valign='top'> <td><div id='one-line'><div class='inline-middle'><div class='fval'><div class='facet-val'><a title='Solid tumors' class="label label-primary loader" target='_self' ng-href="/substances?facet=Condition%2FSolid tumors"><div class='facet-val-text'>Solid tumors</div></a></div></div></div><info-popup><div class='info-popup-container'><div><span class='pop-sub-key '>Sources:&nbsp</span><span class='pop-sub-val'><span class='ext-link'><a target='_self' href='https://www.ncbi.nlm.nih.gov/pubmed/9829740'>https://www.ncbi.nlm.nih.gov/pubmed/9829740</a></span></span></div></div></info-popup></div></td> <td>Primary</td> <td></td> <td><div class='fval'><div class='facet-val'><a title='Phase I' class="label label-primary loader" target='_self' ng-href="/substances?facet=Highest Phase%2FPhase I"><div class='facet-val-text'>Phase I</div></a></div></div></td> <td><div class='inline-middle'>Unknown</div><info-popup><div class='info-popup-container'><div class='pop-key'><h4>Approved Use</h4><div class='pop-val'>Unknown</div></div></div></info-popup></td> </tr> <tr class='non-small_cell_lung_cancer ' valign='top'> <td><div id='one-line'><div class='inline-middle'><div class='fval'><div class='facet-val'><a title='Non-small cell lung cancer' class="label label-primary loader" target='_self' ng-href="/substances?facet=Condition%2FNon-small cell lung cancer"><div class='facet-val-text'>Non-small cell lung cancer</div></a></div></div></div><info-popup><div class='info-popup-container'><div><span class='pop-sub-key '>Sources:&nbsp</span><span class='pop-sub-val'><span class='ext-link'><a target='_self' href='https://www.ncbi.nlm.nih.gov/pubmed/8192104'>https://www.ncbi.nlm.nih.gov/pubmed/8192104</a></span></span></div></div></info-popup></div></td> <td>Primary</td> <td></td> <td><div class='fval'><div class='facet-val'><a title='Phase II' class="label label-primary loader" target='_self' ng-href="/substances?facet=Highest Phase%2FPhase II"><div class='facet-val-text'>Phase II</div></a></div></div></td> <td><div class='inline-middle'>Unknown</div><info-popup><div class='info-popup-container'><div class='pop-key'><h4>Approved Use</h4><div class='pop-val'>Unknown</div></div></div></info-popup></td> </tr> <tr class='hepatocellular_carcinoma ' valign='top'> <td><div id='one-line'><div class='inline-middle'><div class='fval'><div class='facet-val'><a title='Hepatocellular carcinoma' class="label label-primary loader" target='_self' ng-href="/substances?facet=Condition%2FHepatocellular carcinoma"><div class='facet-val-text'>Hepatocellular carcinoma</div></a></div></div></div><info-popup><div class='info-popup-container'><div><span class='pop-sub-key '>Sources:&nbsp</span><span class='pop-sub-val'><span class='ext-link'><a target='_self' href='https://www.ncbi.nlm.nih.gov/pubmed/2173394'>https://www.ncbi.nlm.nih.gov/pubmed/2173394</a></span></span></div></div></info-popup></div></td> <td>Primary</td> <td></td> <td><div class='fval'><div class='facet-val'><a title='Phase II' class="label label-primary loader" target='_self' ng-href="/substances?facet=Highest Phase%2FPhase II"><div class='facet-val-text'>Phase II</div></a></div></div></td> <td><div class='inline-middle'>Unknown</div><info-popup><div class='info-popup-container'><div class='pop-key'><h4>Approved Use</h4><div class='pop-val'>Unknown</div></div></div></info-popup></td> </tr> <tr class='ovarian_cancer ' valign='top'> <td><div id='one-line'><div class='inline-middle'><div class='fval'><div class='facet-val'><a title='Ovarian cancer' class="label label-primary loader" target='_self' ng-href="/substances?facet=Condition%2FOvarian cancer"><div class='facet-val-text'>Ovarian cancer</div></a></div></div></div><info-popup><div class='info-popup-container'><div><span class='pop-sub-key '>Sources:&nbsp</span><span class='pop-sub-val'><span class='ext-link'><a target='_self' href='https://www.ncbi.nlm.nih.gov/pubmed/2793383'>https://www.ncbi.nlm.nih.gov/pubmed/2793383</a></span></span></div></div></info-popup></div></td> <td>Primary</td> <td></td> <td><div class='fval'><div class='facet-val'><a title='Phase II' class="label label-primary loader" target='_self' ng-href="/substances?facet=Highest Phase%2FPhase II"><div class='facet-val-text'>Phase II</div></a></div></div></td> <td><div class='inline-middle'>Unknown</div><info-popup><div class='info-popup-container'><div class='pop-key'><h4>Approved Use</h4><div class='pop-val'>Unknown</div></div></div></info-popup></td> </tr> <tr class='breast_cancer ' valign='top'> <td><div id='one-line'><div class='inline-middle'><div class='fval'><div class='facet-val'><a title='Breast cancer' class="label label-primary loader" target='_self' ng-href="/substances?facet=Condition%2FBreast cancer"><div class='facet-val-text'>Breast cancer</div></a></div></div></div><info-popup><div class='info-popup-container'><div><span class='pop-sub-key '>Sources:&nbsp</span><span class='pop-sub-val'><span class='ext-link'><a target='_self' href='https://www.ncbi.nlm.nih.gov/pubmed/3530455'>https://www.ncbi.nlm.nih.gov/pubmed/3530455</a></span></span></div></div></info-popup></div></td> <td>Primary</td> <td></td> <td><div class='fval'><div class='facet-val'><a title='Phase II' class="label label-primary loader" target='_self' ng-href="/substances?facet=Highest Phase%2FPhase II"><div class='facet-val-text'>Phase II</div></a></div></div></td> <td><div class='inline-middle'>Unknown</div><info-popup><div class='info-popup-container'><div class='pop-key'><h4>Approved Use</h4><div class='pop-val'>Unknown</div></div></div></info-popup></td> </tr></tbody></table> </div> </div> </div></uib-tab></uib-tabset></div></card> </div> <div ng-cloak class="fade-ng-cloak ng-cloak"> <card eid='adverseevents' card-title='Adverse Events' count='0' audit='audit'><div ng-init="tabActivePub=0" class="col-md-12 rancho-datatable"><input style='display:none;' type='number' id='tabActivePub' ng-model='tabActivePub'> <uib-tabset active='tabActivePub'><uib-tab ng-click='hashChange("tabActivePub:0")' index='0'><uib-tab-heading >Doses<a class='info-rancho' data-toggle="popover" data-animation="true" data-placement="top" data-trigger="click focus" data-html="true" data-original-title="" title="" data-content="<span>Manually Curated </span>"><i class="fa fa-shield"></i></a></uib-tab-heading><div class="col-md-12"> <div class="panel panel-default additional"> <div class="panel-heading"> <h3 class="panel-title flexbox"> Doses </h3> </div> <div class="panel-body additional-data"> <table class="tabtab gsrs-datatable" ><thead><th>Dose</th><th>Population</th><th>Adverse events</th></thead><tbody><tr class=' ' valign='top'> <td><div class='inline-middle'>31 mg/m2 1 times / day multiple, intravenous<br>Highest studied dose</div><info-popup><div class='info-popup-container'>Dose: <span class='infopop-line-value'>31 mg/m2, 1 times / day</span><br>Route: <span class='infopop-line-value'>intravenous</span><br>Route: <span class='infopop-line-value'>multiple</span><br>Dose: <span class='infopop-line-value'>31 mg/m2, 1 times / day</span><br>Sources: <div class='infopop-sources'><a href='https://pubmed.ncbi.nlm.nih.gov/8729948/' target='_blank'>https://pubmed.ncbi.nlm.nih.gov/8729948/</a><br></div></div></info-popup></td> <td><div class='inline-middle'>unhealthy, CHILD|ADOLESCENT</div><info-popup><div class='info-popup-container'>Health Status: <span class='infopop-line-value'>unhealthy</span><br>Age Group: <span class='infopop-line-value'>CHILD|ADOLESCENT</span><br>Sex: <span class='infopop-line-value'>M+F</span><br>Food Status: <span class='infopop-line-value'>UNKNOWN</span><br>Sources: <div class='infopop-sources'><a href='https://pubmed.ncbi.nlm.nih.gov/8729948/' target='_blank'>https://pubmed.ncbi.nlm.nih.gov/8729948/</a><br></div></div></info-popup></td> <td><div class='inline-middle'>DLT: Myelosuppression...<br></div><info-popup><div class='info-popup-container'>Dose limiting toxicities:<br><div class='infopop-padded'>Myelosuppression (grade 4, 50%)<br></div>Sources: <div class='infopop-sources'><a href='https://pubmed.ncbi.nlm.nih.gov/8729948/' target='_blank'>https://pubmed.ncbi.nlm.nih.gov/8729948/</a><br></div></div></info-popup></td> </tr> <tr class=' ' valign='top'> <td><div class='inline-middle'>26 mg/m2 1 times / day multiple, intravenous<br>MTD</div><info-popup><div class='info-popup-container'>Dose: <span class='infopop-line-value'>26 mg/m2, 1 times / day</span><br>Route: <span class='infopop-line-value'>intravenous</span><br>Route: <span class='infopop-line-value'>multiple</span><br>Dose: <span class='infopop-line-value'>26 mg/m2, 1 times / day</span><br>Sources: <div class='infopop-sources'><a href='https://pubmed.ncbi.nlm.nih.gov/8729948/' target='_blank'>https://pubmed.ncbi.nlm.nih.gov/8729948/</a><br></div></div></info-popup></td> <td><div class='inline-middle'>unhealthy, CHILD|ADOLESCENT</div><info-popup><div class='info-popup-container'>Health Status: <span class='infopop-line-value'>unhealthy</span><br>Age Group: <span class='infopop-line-value'>CHILD|ADOLESCENT</span><br>Sex: <span class='infopop-line-value'>M+F</span><br>Food Status: <span class='infopop-line-value'>UNKNOWN</span><br>Sources: <div class='infopop-sources'><a href='https://pubmed.ncbi.nlm.nih.gov/8729948/' target='_blank'>https://pubmed.ncbi.nlm.nih.gov/8729948/</a><br></div></div></info-popup></td> <td><div class='inline-middle'></div><info-popup><div class='info-popup-container'>Sources: <div class='infopop-sources'><a href='https://pubmed.ncbi.nlm.nih.gov/8729948/' target='_blank'>https://pubmed.ncbi.nlm.nih.gov/8729948/</a><br></div></div></info-popup></td> </tr></tbody></table> </div> </div> </div></uib-tab><uib-tab ng-click='hashChange("tabActivePub:1")' index='1'><uib-tab-heading >AEs<a class='info-rancho' data-toggle="popover" data-animation="true" data-placement="top" data-trigger="click focus" data-html="true" data-original-title="" title="" data-content="<span>Manually Curated </span>"><i class="fa fa-shield"></i></a></uib-tab-heading><div class="col-md-12"> <div class="panel panel-default additional"> <div class="panel-heading"> <h3 class="panel-title flexbox"> AEs </h3> </div> <div class="panel-body additional-data"> <table class="tabtab gsrs-datatable" ><thead><th>AE</th><th>Significance</th><th>Dose</th><th>Population</th></thead><tbody><tr class=' ' valign='top'> <td>Myelosuppression</td> <td>grade 4, 50%<br>DLT</td> <td><div class='inline-middle'>31 mg/m2 1 times / day multiple, intravenous<br>Highest studied dose</div><info-popup><div class='info-popup-container'>Dose: <span class='infopop-line-value'>31 mg/m2, 1 times / day</span><br>Route: <span class='infopop-line-value'>intravenous</span><br>Route: <span class='infopop-line-value'>multiple</span><br>Dose: <span class='infopop-line-value'>31 mg/m2, 1 times / day</span><br>Sources: <div class='infopop-sources'><a href='https://pubmed.ncbi.nlm.nih.gov/8729948/' target='_blank'>https://pubmed.ncbi.nlm.nih.gov/8729948/</a><br></div></div></info-popup></td> <td><div class='inline-middle'>unhealthy, CHILD|ADOLESCENT</div><info-popup><div class='info-popup-container'>Health Status: <span class='infopop-line-value'>unhealthy</span><br>Age Group: <span class='infopop-line-value'>CHILD|ADOLESCENT</span><br>Sex: <span class='infopop-line-value'>M+F</span><br>Food Status: <span class='infopop-line-value'>UNKNOWN</span><br>Sources: <div class='infopop-sources'><a href='https://pubmed.ncbi.nlm.nih.gov/8729948/' target='_blank'>https://pubmed.ncbi.nlm.nih.gov/8729948/</a><br></div></div></info-popup></td> </tr></tbody></table> </div> </div> </div></uib-tab></uib-tabset></div></card> </div> <div ng-cloak class="fade-ng-cloak ng-cloak"> <card eid='dditox' card-title='DDI & Tox' count='0' audit='audit'><div ng-init="tabActivePub=0" class="col-md-12 rancho-datatable"><input style='display:none;' type='number' id='tabActivePub' ng-model='tabActivePub'> <uib-tabset active='tabActivePub'><uib-tab ng-click='hashChange("tabActivePub:0")' index='0'><uib-tab-heading >Overview<a class='info-rancho' data-toggle="popover" data-animation="true" data-placement="top" data-trigger="click focus" data-html="true" data-original-title="" title="" data-content="<span>Manually Curated </span>"><i class="fa fa-shield"></i></a></uib-tab-heading><div class="col-md-12"> <div class="panel panel-default additional"> <div class="panel-heading"> <h3 class="panel-title flexbox"> Overview </h3> </div> <div class="panel-body additional-data"> <table class="tabtab" ><thead><th>CYP3A4</th><th>CYP2C9</th><th>CYP2D6</th><th>hERG</th></thead><tbody><tr class=' ' valign='top'> <td><div class='fval'><div class='facet-val'><a title='inducer' class="label label-primary loader" target='_self' ng-href="/substances?facet=CYP3A4%2Finducer"><div class='facet-val-text'>inducer</div></a></div></div><br></td> <td></td> <td></td> <td><div class='fval'><div class='facet-val'><a title='inhibitor' class="label label-primary loader" target='_self' ng-href="/substances?facet=hERG%2Finhibitor"><div class='facet-val-text'>inhibitor</div></a></div></div><br></td> </tr></tbody></table> </div> </div> </div><div class="col-md-12"> <div class="panel panel-default additional"> <div class="panel-heading"> <h3 class="panel-title flexbox"> OverviewOther </h3> </div> <div class="panel-body additional-data"> <table class="tabtab" ><thead><th>Other Inhibitor</th><th>Other Substrate</th><th>Other Inducer</th></thead><tbody><tr class=' ' valign='top'> <td><div class='fval'><div class='facet-val'><a title='OATP1B1' class="label label-primary loader" target='_self' ng-href="/substances?facet=Other Inhibitor%2FOATP1B1"><div class='facet-val-text'>OATP1B1</div></a></div></div><br><div class='fval'><div class='facet-val'><a title='CYP19A1' class="label label-primary loader" target='_self' ng-href="/substances?facet=Other Inhibitor%2FCYP19A1"><div class='facet-val-text'>CYP19A1</div></a></div></div><br><div class='fval'><div class='facet-val'><a title='OATP1B3' class="label label-primary loader" target='_self' ng-href="/substances?facet=Other Inhibitor%2FOATP1B3"><div class='facet-val-text'>OATP1B3</div></a></div></div><br></td> <td><div class='fval'><div class='facet-val'><a title='P-gp' class="label label-primary loader" target='_self' ng-href="/substances?facet=Other Substrate%2FP-gp"><div class='facet-val-text'>P-gp</div></a></div></div><br></td> <td></td> </tr></tbody></table> </div> </div> </div></uib-tab><uib-tab ng-click='hashChange("tabActivePub:1")' index='1'><uib-tab-heading >Drug as perpetrator<a class='info-rancho' data-toggle="popover" data-animation="true" data-placement="top" data-trigger="click focus" data-html="true" data-original-title="" title="" data-content="<span>Manually Curated </span>"><i class="fa fa-shield"></i></a></uib-tab-heading><div class="col-md-12"> <div class="panel panel-default additional"> <div class="panel-heading"> <h3 class="panel-title flexbox"> Drug as perpetrator </h3> </div> <div class="panel-body additional-data"> <table class="tabtab gsrs-datatable" ><thead><th>Target</th><th>Modality</th><th>Activity</th><th>Metabolite</th><th>Clinical evidence</th></thead><tbody><tr class=' ' valign='top'> <td><div class='fval'><div class='facet-val'><a title='CYP19A1' class="label label-primary loader" target='_self' ng-href="/substances?facet=Perpetrator Target%2FCYP19A1"><div class='facet-val-text'>CYP19A1</div></a></div></div></td> <td><div id='one-line'><div class='inline-middle'><div class='fval'><div class='facet-val'><a title='inhibitor' class="label label-primary loader" target='_self' ng-href="/substances?facet=Perpetrator Modality%2Finhibitor"><div class='facet-val-text'>inhibitor</div></a></div></div></div><info-popup><div class='info-popup-container'><div><span class='pop-sub-key '>Sources:&nbsp</span><span class='pop-sub-val'><span class='ext-link'><a target='_self' href='https://pubchem.ncbi.nlm.nih.gov/compound/294641#section=BioAssay-Results'>https://pubchem.ncbi.nlm.nih.gov/compound/294641#section=BioAssay-Results</a></span></span></div><div><span class='pop-sub-key '>Page:&nbsp</span><span class='pop-sub-val'>4.0</span></div></div></info-popup></div></td> <td>inconclusive [IC50 6.6824 uM]</td> <td></td> <td><div id='one-line'><div class='inline-middle'></div></div></td> </tr> <tr class=' ' valign='top'> <td><div class='fval'><div class='facet-val'><a title='CYP3A4' class="label label-primary loader" target='_self' ng-href="/substances?facet=Perpetrator Target%2FCYP3A4"><div class='facet-val-text'>CYP3A4</div></a></div></div></td> <td><div id='one-line'><div class='inline-middle'><div class='fval'><div class='facet-val'><a title='inducer' class="label label-primary loader" target='_self' ng-href="/substances?facet=Perpetrator Modality%2Finducer"><div class='facet-val-text'>inducer</div></a></div></div></div><info-popup><div class='info-popup-container'><div><span class='pop-sub-key '>Sources:&nbsp</span><span class='pop-sub-val'><span class='ext-link'><a target='_self' href='https://pubchem.ncbi.nlm.nih.gov/compound/294641#section=BioAssay-Results'>https://pubchem.ncbi.nlm.nih.gov/compound/294641#section=BioAssay-Results</a></span></span></div><div><span class='pop-sub-key '>Page:&nbsp</span><span class='pop-sub-val'>298.0</span></div></div></info-popup></div></td> <td>no</td> <td></td> <td><div id='one-line'><div class='inline-middle'></div></div></td> </tr> <tr class=' ' valign='top'> <td><div class='fval'><div class='facet-val'><a title='OATP1B1' class="label label-primary loader" target='_self' ng-href="/substances?facet=Perpetrator Target%2FOATP1B1"><div class='facet-val-text'>OATP1B1</div></a></div></div></td> <td><div id='one-line'><div class='inline-middle'><div class='fval'><div class='facet-val'><a title='inhibitor' class="label label-primary loader" target='_self' ng-href="/substances?facet=Perpetrator Modality%2Finhibitor"><div class='facet-val-text'>inhibitor</div></a></div></div></div><info-popup><div class='info-popup-container'><div><span class='pop-sub-key '>Sources:&nbsp</span><span class='pop-sub-val'><span class='ext-link'><a target='_self' href='https://www.ebi.ac.uk/chembl/g/#browse/activities/full_state/eyJsaXN0Ijp7InNldHRpbmdzX3BhdGgiOiJFU19JTkRFWEVTX05PX01BSU5fU0VBUkNILkFDVElWSVRZIiwiY3VzdG9tX3F1ZXJ5IjoidGFyZ2V0X2NoZW1ibF9pZDpDSEVNQkwxNjk3NjY4IiwidXNlX2N1c3RvbV9xdWVyeSI6dHJ1ZSwic2VhcmNoX3Rlcm0iOiIiLCJ0ZXh0X2ZpbHRlciI6IkNIRU1CTDEyMzExMDEifX0='>https://www.ebi.ac.uk/chembl/g/#browse/activities/full_state/eyJsaXN0Ijp7InNldHRpbmdzX3BhdGgiOiJFU19JTkRFWEVTX05PX01BSU5fU0VBUkNILkFDVElWSVRZIiwiY3VzdG9tX3F1ZXJ5IjoidGFyZ2V0X2NoZW1ibF9pZDpDSEVNQkwxNjk3NjY4IiwidXNlX2N1c3RvbV9xdWVyeSI6dHJ1ZSwic2VhcmNoX3Rlcm0iOiIiLCJ0ZXh0X2ZpbHRlciI6IkNIRU1CTDEyMzExMDEifX0=</a></span></span></div></div></info-popup></div></td> <td>yes [Inhibition 10 uM]</td> <td></td> <td><div id='one-line'><div class='inline-middle'></div></div></td> </tr> <tr class=' ' valign='top'> <td><div class='fval'><div class='facet-val'><a title='OATP1B3' class="label label-primary loader" target='_self' ng-href="/substances?facet=Perpetrator Target%2FOATP1B3"><div class='facet-val-text'>OATP1B3</div></a></div></div></td> <td><div id='one-line'><div class='inline-middle'><div class='fval'><div class='facet-val'><a title='inhibitor' class="label label-primary loader" target='_self' ng-href="/substances?facet=Perpetrator Modality%2Finhibitor"><div class='facet-val-text'>inhibitor</div></a></div></div></div><info-popup><div class='info-popup-container'><div><span class='pop-sub-key '>Sources:&nbsp</span><span class='pop-sub-val'><span class='ext-link'><a target='_self' href='https://www.ebi.ac.uk/chembl/g/#browse/activities/full_state/eyJsaXN0Ijp7InNldHRpbmdzX3BhdGgiOiJFU19JTkRFWEVTX05PX01BSU5fU0VBUkNILkFDVElWSVRZIiwiY3VzdG9tX3F1ZXJ5IjoidGFyZ2V0X2NoZW1ibF9pZDpDSEVNQkwxNzQzMTIxIiwidXNlX2N1c3RvbV9xdWVyeSI6dHJ1ZSwic2VhcmNoX3Rlcm0iOiIiLCJ0ZXh0X2ZpbHRlciI6IkNIRU1CTDEyMzExMDEifX0='>https://www.ebi.ac.uk/chembl/g/#browse/activities/full_state/eyJsaXN0Ijp7InNldHRpbmdzX3BhdGgiOiJFU19JTkRFWEVTX05PX01BSU5fU0VBUkNILkFDVElWSVRZIiwiY3VzdG9tX3F1ZXJ5IjoidGFyZ2V0X2NoZW1ibF9pZDpDSEVNQkwxNzQzMTIxIiwidXNlX2N1c3RvbV9xdWVyeSI6dHJ1ZSwic2VhcmNoX3Rlcm0iOiIiLCJ0ZXh0X2ZpbHRlciI6IkNIRU1CTDEyMzExMDEifX0=</a></span></span></div></div></info-popup></div></td> <td>yes [Inhibition 10 uM]</td> <td></td> <td><div id='one-line'><div class='inline-middle'></div></div></td> </tr></tbody></table> </div> </div> </div></uib-tab><uib-tab ng-click='hashChange("tabActivePub:2")' index='2'><uib-tab-heading >Drug as victim<a class='info-rancho' data-toggle="popover" data-animation="true" data-placement="top" data-trigger="click focus" data-html="true" data-original-title="" title="" data-content="<span>Manually Curated </span>"><i class="fa fa-shield"></i></a></uib-tab-heading><div class="col-md-12"> <div class="panel panel-default additional"> <div class="panel-heading"> <h3 class="panel-title flexbox"> Drug as victim </h3> </div> <div class="panel-body additional-data"> <table class="tabtab gsrs-datatable" ><thead><th>Target</th><th>Modality</th><th>Activity</th><th>Metabolite</th><th>Clinical evidence</th></thead><tbody><tr class=' ' valign='top'> <td><div class='fval'><div class='facet-val'><a title='P-gp' class="label label-primary loader" target='_self' ng-href="/substances?facet=Victim Target%2FP-gp"><div class='facet-val-text'>P-gp</div></a></div></div></td> <td><div id='one-line'><div class='inline-middle'><div class='fval'><div class='facet-val'><a title='substrate' class="label label-primary loader" target='_self' ng-href="/substances?facet=Victim Modality%2Fsubstrate"><div class='facet-val-text'>substrate</div></a></div></div></div><info-popup><div class='info-popup-container'><div><span class='pop-sub-key '>Sources:&nbsp</span><span class='pop-sub-val'><span class='ext-link'><a target='_self' href='https://pubchem.ncbi.nlm.nih.gov/compound/294641#section=BioAssay-Results'>https://pubchem.ncbi.nlm.nih.gov/compound/294641#section=BioAssay-Results</a></span></span></div><div><span class='pop-sub-key '>Page:&nbsp</span><span class='pop-sub-val'>3 | 297</span></div></div></info-popup></div></td> <td>inconclusive</td> <td></td> <td><div id='one-line'><div class='inline-middle'></div></div></td> </tr></tbody></table> </div> </div> </div></uib-tab><uib-tab ng-click='hashChange("tabActivePub:3")' index='3'><uib-tab-heading >Tox targets<a class='info-rancho' data-toggle="popover" data-animation="true" data-placement="top" data-trigger="click focus" data-html="true" data-original-title="" title="" data-content="<span>Manually Curated </span>"><i class="fa fa-shield"></i></a></uib-tab-heading><div class="col-md-12"> <div class="panel panel-default additional"> <div class="panel-heading"> <h3 class="panel-title flexbox"> Tox targets </h3> </div> <div class="panel-body additional-data"> <table class="tabtab gsrs-datatable" ><thead><th>Target</th><th>Modality</th><th>Activity</th><th>Metabolite</th><th>Clinical evidence</th></thead><tbody><tr class=' ' valign='top'> <td><div class='fval'><div class='facet-val'><a title='hERG' class="label label-primary loader" target='_self' ng-href="/substances?facet=Tox Target%2FhERG"><div class='facet-val-text'>hERG</div></a></div></div></td> <td><div id='one-line'><div class='inline-middle'><div class='fval'><div class='facet-val'><a title='inhibitor' class="label label-primary loader" target='_self' ng-href="/substances?facet=Tox Modality%2Finhibitor"><div class='facet-val-text'>inhibitor</div></a></div></div></div><info-popup><div class='info-popup-container'><div><span class='pop-sub-key '>Sources:&nbsp</span><span class='pop-sub-val'><span class='ext-link'><a target='_self' href='https://pubchem.ncbi.nlm.nih.gov/compound/294641#section=BioAssay-Results'>https://pubchem.ncbi.nlm.nih.gov/compound/294641#section=BioAssay-Results</a></span></span></div><div><span class='pop-sub-key '>Page:&nbsp</span><span class='pop-sub-val'>258.0</span></div></div></info-popup></div></td> <td></td> <td></td> <td><div id='one-line'><div class='inline-middle'></div></div></td> </tr></tbody></table> </div> </div> </div></uib-tab></uib-tabset></div></card> </div> <div ng-cloak class="fade-ng-cloak ng-cloak"> <card eid='publications' card-title='Publications' count='0' audit='audit'><div ng-init="tabActivePub=0" class="col-md-12 rancho-datatable"><input style='display:none;' type='number' id='tabActivePub' ng-model='tabActivePub'> <uib-tabset active='tabActivePub'><uib-tab ng-click='hashChange("tabActivePub:0")' index='0'><uib-tab-heading >PubMed<a class='info-rancho' data-toggle="popover" data-animation="true" data-placement="top" data-trigger="click focus" data-html="true" data-original-title="" title="" data-content="<span>Manually Curated </span>"><i class="fa fa-shield"></i></a></uib-tab-heading><div class="col-md-12"> <div class="panel panel-default additional"> <div class="panel-heading"> <h3 class="panel-title flexbox"> PubMed </h3> </div> <div class="panel-body additional-data"> <table class="tabtab gsrs-datatable" ><thead><th>Title</th><th>Date</th><th>PubMed</th></thead><tbody><tr class=' ' valign='top'> <td>Mechanism of S-(1,2-dichlorovinyl)glutathione-induced nephrotoxicity.</td> <td><div id='one-line'>1986 Jan 15</div></td> <td><div id='one-line'><a href='https://www.ncbi.nlm.nih.gov/pubmed/2867768' title='https://www.ncbi.nlm.nih.gov/pubmed/2867768'>2867768</a></div></td> </tr> <tr class=' ' valign='top'> <td>Sequential oxidation and glutathione addition to 1,4-benzoquinone: correlation of toxicity with increased glutathione substitution.</td> <td><div id='one-line'>1988 Dec</div></td> <td><div id='one-line'><a href='https://www.ncbi.nlm.nih.gov/pubmed/3200250' title='https://www.ncbi.nlm.nih.gov/pubmed/3200250'>3200250</a></div></td> </tr> <tr class=' ' valign='top'> <td>Inhibition of gamma-glutamyl transpeptidase potentiates the nephrotoxicity of glutathione-conjugated chlorohydroquinones.</td> <td><div id='one-line'>1991 Aug</div></td> <td><div id='one-line'><a href='https://www.ncbi.nlm.nih.gov/pubmed/1678558' title='https://www.ncbi.nlm.nih.gov/pubmed/1678558'>1678558</a></div></td> </tr> <tr class=' ' valign='top'> <td>In vivo nephrotoxic action of an isomeric mixture of S-(1-phenyl-2-hydroxyethyl)glutathione and S-(2-phenyl-2-hydroxyethyl)glutathione in Fischer-344 rats.</td> <td><div id='one-line'>1991 Mar 25</div></td> <td><div id='one-line'><a href='https://www.ncbi.nlm.nih.gov/pubmed/1673268' title='https://www.ncbi.nlm.nih.gov/pubmed/1673268'>1673268</a></div></td> </tr> <tr class=' ' valign='top'> <td>Endogenously formed leukotriene C4 activates LTC4 receptors in guinea pig tracheal strips.</td> <td><div id='one-line'>1991 Mar 26</div></td> <td><div id='one-line'><a href='https://www.ncbi.nlm.nih.gov/pubmed/1651863' title='https://www.ncbi.nlm.nih.gov/pubmed/1651863'>1651863</a></div></td> </tr> <tr class=' ' valign='top'> <td>Nephrotoxicity of 4-amino-3-S-glutathionylphenol and its modulation by metabolism or transport inhibitors.</td> <td><div id='one-line'>1994</div></td> <td><div id='one-line'><a href='https://www.ncbi.nlm.nih.gov/pubmed/7909430' title='https://www.ncbi.nlm.nih.gov/pubmed/7909430'>7909430</a></div></td> </tr> <tr class=' ' valign='top'> <td>Leukotrienes and alpha-naphthylisothiocyanate-induced liver injury.</td> <td><div id='one-line'>1995 Jun 26</div></td> <td><div id='one-line'><a href='https://www.ncbi.nlm.nih.gov/pubmed/7624871' title='https://www.ncbi.nlm.nih.gov/pubmed/7624871'>7624871</a></div></td> </tr> <tr class=' ' valign='top'> <td>Role of the renal cysteine conjugate beta-lyase pathway in inhaled compound A nephrotoxicity in rats.</td> <td><div id='one-line'>1998 Jun</div></td> <td><div id='one-line'><a href='https://www.ncbi.nlm.nih.gov/pubmed/9637657' title='https://www.ncbi.nlm.nih.gov/pubmed/9637657'>9637657</a></div></td> </tr> <tr class=' ' valign='top'> <td>Acivicin induces apoptosis independently of gamma-glutamyltranspeptidase activity.</td> <td><div id='one-line'>2001 Aug 3</div></td> <td><div id='one-line'><a href='https://www.ncbi.nlm.nih.gov/pubmed/11478776' title='https://www.ncbi.nlm.nih.gov/pubmed/11478776'>11478776</a></div></td> </tr> <tr class=' ' valign='top'> <td>Concentration-dependent effects of endogenous S-nitrosoglutathione on gene regulation by specificity proteins Sp3 and Sp1.</td> <td><div id='one-line'>2004 May 15</div></td> <td><div id='one-line'><a href='https://www.ncbi.nlm.nih.gov/pubmed/14766015' title='https://www.ncbi.nlm.nih.gov/pubmed/14766015'>14766015</a></div></td> </tr> <tr class=' ' valign='top'> <td>Contribution of acetaminophen-cysteine to acetaminophen nephrotoxicity II. Possible involvement of the gamma-glutamyl cycle.</td> <td><div id='one-line'>2005 Jan 15</div></td> <td><div id='one-line'><a href='https://www.ncbi.nlm.nih.gov/pubmed/15629191' title='https://www.ncbi.nlm.nih.gov/pubmed/15629191'>15629191</a></div></td> </tr> <tr class=' ' valign='top'> <td>Role of gamma-glutamyl transpeptidase in redox regulation of K+ channel remodeling in postmyocardial infarction rat hearts.</td> <td><div id='one-line'>2009 Aug</div></td> <td><div id='one-line'><a href='https://www.ncbi.nlm.nih.gov/pubmed/19419996' title='https://www.ncbi.nlm.nih.gov/pubmed/19419996'>19419996</a></div></td> </tr> <tr class=' ' valign='top'> <td>An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery.</td> <td><div id='one-line'>2013 Mar</div></td> <td><div id='one-line'><a href='https://www.ncbi.nlm.nih.gov/pubmed/22996645' title='https://www.ncbi.nlm.nih.gov/pubmed/22996645'>22996645</a></div></td> </tr></tbody></table> </div> </div> </div></uib-tab><uib-tab ng-click='hashChange("tabActivePub:1")' index='1'><uib-tab-heading >Patents<a class='info-rancho' data-toggle="popover" data-animation="true" data-placement="top" data-trigger="click focus" data-html="true" data-original-title="" title="" data-content="<span>Manually Curated </span>"><i class="fa fa-shield"></i></a></uib-tab-heading><div class="col-md-12"> <div class="panel panel-default additional"> <div class="panel-heading"> <h3 class="panel-title flexbox"> Patents </h3> </div> <div class="panel-body additional-data"> <div class='fval'><div class='facet-val'><a title='04458084' class="label label-primary loader" target='_self' ng-href="/substances?facet=Patents%2F04458084"><div class='facet-val-text'>04458084</div></a></div></div> </div> </div> </div></uib-tab></uib-tabset></div></card> </div> <div ng-cloak class="fade-ng-cloak ng-cloak"> <card eid='application' card-title='Application' count='0' audit='audit'><div class="col-md-12"> <div class="panel panel-default additional"> <div class="panel-heading"> <h3 class="panel-title flexbox"> Sample Use Guides </h3> </div> <div class="panel-body additional-data"> <div> <div class="sub-title">In Vivo Use Guide <info-popup><div class='info-popup-container'><div><span class='pop-sub-key '>Sources:&nbsp</span><span class='pop-sub-val'><span class='ext-link'><a target='_self' href='https://www.ncbi.nlm.nih.gov/pubmed/9829740'>https://www.ncbi.nlm.nih.gov/pubmed/9829740</a></span></span></div></div></info-popup><a class='info-rancho' data-toggle="popover" data-animation="true" data-placement="top" data-trigger="click focus" data-html="true" data-original-title="" title="" data-content="<span>Manually Curated </span>"><i class="fa fa-shield"></i></a></div> <div> Patients were treated with acivicin on a 72-h continuous infusion schedule at doses ranging from 25 to 60 mg/m2/day every 3 weeks.<div class="subsub-title">Route of Administration:<span class="val"> Intravenous </span></div></div> </div><div> <div class="sub-title">In Vitro Use Guide <info-popup><div class='info-popup-container'><div><span class='pop-sub-key '>Sources:&nbsp</span><span class='pop-sub-val'><span class='ext-link'><a target='_self' href='https://www.ncbi.nlm.nih.gov/pubmed/18697567'>https://www.ncbi.nlm.nih.gov/pubmed/18697567</a></span></span></div></div></info-popup><a class='info-rancho' data-toggle="popover" data-animation="true" data-placement="top" data-trigger="click focus" data-html="true" data-original-title="" title="" data-content="<span>Manually Curated </span>"><i class="fa fa-shield"></i></a></div> <div> Colorimetric assay using MTT labeling reagent was separately performed with MCF-7 and OAW-42 cells to determine cell proliferation in presence of glutaminase and acivicin in vitro. Actively growing cells were seeded in three 96-well microtiter plates at a density of 1x10^4 cells/well. Triplicate wells were treated with the following: (1) culture medium only (control), (2) Acivicin 5mkM, (3) Acivicin 10mkM, (4) Acivicin 15mkM. Incubation times for the three plates was 24. 48 and 72 hr respectively after which cell proliferation assay (MTT assay) was performed using Cell Proliferation Kit I. Boehringer Mannheim, Germany (MTT, 1465007) according to manufacftirer’s instructions.</div> </div> </div> </div> </div></card> </div> <div ng-cloak class="fade-ng-cloak ng-cloak"> <card eid='details' card-title='Record Details' count='0' audit='audit'> <div class="row"> <div class="col-md-7" > <table class="table kv-table" id="moiety-table"> <tr> <td>Substance Class</td> <td class="monospace flexbox"> Chemical <info-popup class="flexbox"> <div class="info-popup-container"> <div> <referencesmanager reftable hide-header="false" show='["typ","tags","cit"]' substance ="'55be1968-94cc-4e6a-a098-7ebaae1a6645'" sreferences = "[{"id":null,"label":"GInAS Reference","term":"76016778-3459-437a-b6ef-86230842e425","href":null,"_matchContext":null},{"id":null,"label":"GInAS Reference","term":"a4806e9f-77b1-4975-9f99-f4c326aaa275","href":null,"_matchContext":null},{"id":null,"label":"GInAS Reference","term":"33582c0e-7dbd-4c71-9ba9-edba8a31faf9","href":null,"_matchContext":null}]" > </referencesmanager> <div class="col-md-12"> <strong>Created</strong> <div id="one-line"> by <code>admin</code> </div> <div id="one-line"> on <code>Fri Dec 15 15:15:52 GMT 2023</code> </div> <strong>Edited</strong> <div id="one-line"> by <code>admin</code> </div> <div id="one-line"> on <code>Fri Dec 15 15:15:52 GMT 2023</code> </div> </div> </div> </div> </info-popup> </td> </tr> <tr> <td>Record UNII</td> <td> <div class= "monospace">O0X60K76I6</div> </td> </tr> <tr> <td>Record Status</td> <td> <code class="monospace-code">Validated (UNII)</code> </td> </tr> <tr> <td>Record Version</td> <td> <code class="monospace-code"> <select style="width: 30%;" aria-label="version" ng-init ="versionNumber = '11'" ng-model = "versionNumber" ng-model-options="{ getterSetter: true }" ng-change = "redirectVersion()"> <option ng-repeat="v in getRange(1, '11')">{{v}}</option> </select> </code> </td> </tr> </table> </div> <div class = "col-md-5 pull-right"> <ul class= "list-inline pull-right list-unstyled"> <li> <download-button uuid="55be1968-94cc-4e6a-a098-7ebaae1a6645" format=format>Download</download-button> </li> </ul> </div> </div> </card> </div> <div ng-cloak class="fade-ng-cloak ng-cloak"> <card eid='names' card-title='Names' count='14' audit='audit'> <table class="table gsrs-datatable" id="namesTable"> <thead> <tr> <th>Name</th> <th>Type</th> <th>Language</th> </tr> </thead> <tbody> <tr> <td> <table class="info-wrapper"> <tr> <td style="width:100%;"> <span>ACIVICIN</span> <span title="Preferred Name" class="pref-check"> <i class="fa fa-check" aria-hidden="true"></i> </span> </td> <td> <info-popup> <div class="info-popup-container"> <div class="locators"> <div> <label>Locators:</label> </div> <span tooltip-append-to-body="true" uib-tooltip="INTERNATIONAL NONPROPRIETARY NAMES (WHO)" class="badge" > INN </span>   <span tooltip-append-to-body="true" uib-tooltip="MARTINDALE" class="badge" > MART. </span>   <span tooltip-append-to-body="true" uib-tooltip="UNITED STATES ADOPTED NAMES" class="badge" > USAN </span>   <span tooltip-append-to-body="true" uib-tooltip="WHO DRUG DICTIONARY" class="badge" > WHO-DD </span>   </div> <label>Naming Organization:</label> USAN   INN   <div> <label>Sources:</label> <referencesmanager reftable hide-header="true" show='["cit"]' substance ="'55be1968-94cc-4e6a-a098-7ebaae1a6645'" sreferences = "[{"id":null,"label":"GInAS Reference","term":"76b5e183-5f3c-4f84-87ae-03774cb48dad","href":null,"_matchContext":null},{"id":null,"label":"GInAS Reference","term":"d92e604e-fd55-4a30-b7bd-fa18e40e4733","href":null,"_matchContext":null},{"id":null,"label":"GInAS Reference","term":"541448c0-3682-43ac-9698-d62a167bfd6b","href":null,"_matchContext":null},{"id":null,"label":"GInAS Reference","term":"702877c0-8859-40ab-969c-b02830e30acc","href":null,"_matchContext":null},{"id":null,"label":"GInAS Reference","term":"59dd7b5c-6650-4df4-a533-807e66f79681","href":null,"_matchContext":null},{"id":null,"label":"GInAS Reference","term":"ca09e9ea-7185-48f9-b178-f0836f13d334","href":null,"_matchContext":null},{"id":null,"label":"GInAS Reference","term":"33582c0e-7dbd-4c71-9ba9-edba8a31faf9","href":null,"_matchContext":null},{"id":null,"label":"GInAS Reference","term":"1ceaa51a-4bcb-46fd-b26b-9dceb4e479ea","href":null,"_matchContext":null},{"id":null,"label":"GInAS Reference","term":"068a0ef8-c824-4f12-adb7-e6e2bdbdd4b0","href":null,"_matchContext":null}]" > </referencesmanager> </div> </div> </info-popup> </td> </tr> </table> </td> <td id="one-line"> Official Name </td> <td > English </td> </tr> <tr> <td> <table class="info-wrapper"> <tr> <td style="width:100%;"> <span>U-42126</span> </td> <td> <info-popup> <div class="info-popup-container"> <div> <label>Source:</label> <referencesmanager reftable hide-header="true" show='["cit"]' substance ="'55be1968-94cc-4e6a-a098-7ebaae1a6645'" sreferences = "[{"id":null,"label":"GInAS Reference","term":"a4806e9f-77b1-4975-9f99-f4c326aaa275","href":null,"_matchContext":null}]" > </referencesmanager> </div> </div> </info-popup> </td> </tr> </table> </td> <td id="one-line"> Code </td> <td > English </td> </tr> <tr> <td> <table class="info-wrapper"> <tr> <td style="width:100%;"> <span>Acivicin [WHO-DD]</span> </td> <td> <info-popup> <div class="info-popup-container"> <div> <label>Source:</label> <referencesmanager reftable hide-header="true" show='["cit"]' substance ="'55be1968-94cc-4e6a-a098-7ebaae1a6645'" sreferences = "[{"id":null,"label":"GInAS Reference","term":"59ea393d-bea3-66a3-6faf-eb25d9342237","href":null,"_matchContext":null}]" > </referencesmanager> </div> </div> </info-popup> </td> </tr> </table> </td> <td id="one-line"> Common Name </td> <td > English </td> </tr> <tr> <td> <table class="info-wrapper"> <tr> <td style="width:100%;"> <span>AT-125</span> </td> <td> <info-popup> <div class="info-popup-container"> <div> <label>Source:</label> <referencesmanager reftable hide-header="true" show='["cit"]' substance ="'55be1968-94cc-4e6a-a098-7ebaae1a6645'" sreferences = "[{"id":null,"label":"GInAS Reference","term":"ca09e9ea-7185-48f9-b178-f0836f13d334","href":null,"_matchContext":null}]" > </referencesmanager> </div> </div> </info-popup> </td> </tr> </table> </td> <td id="one-line"> Code </td> <td > English </td> </tr> <tr> <td> <table class="info-wrapper"> <tr> <td style="width:100%;"> <span>U 42126</span> </td> <td> <info-popup> <div class="info-popup-container"> <div> <label>Source:</label> <referencesmanager reftable hide-header="true" show='["cit"]' substance ="'55be1968-94cc-4e6a-a098-7ebaae1a6645'" sreferences = "[{"id":null,"label":"GInAS Reference","term":"f1b461c4-fbbd-41aa-b047-d0bf2cae6f45","href":null,"_matchContext":null}]" > </referencesmanager> </div> </div> </info-popup> </td> </tr> </table> </td> <td id="one-line"> Code </td> <td > English </td> </tr> <tr> <td> <table class="info-wrapper"> <tr> <td style="width:100%;"> <span>NSC-163501</span> </td> <td> <info-popup> <div class="info-popup-container"> <div> <label>Source:</label> <referencesmanager reftable hide-header="true" show='["cit"]' substance ="'55be1968-94cc-4e6a-a098-7ebaae1a6645'" sreferences = "[{"id":null,"label":"GInAS Reference","term":"6ebcf8d7-d647-4724-a729-2ac41f08ef41","href":null,"_matchContext":null}]" > </referencesmanager> </div> </div> </info-popup> </td> </tr> </table> </td> <td id="one-line"> Code </td> <td > English </td> </tr> <tr> <td> <table class="info-wrapper"> <tr> <td style="width:100%;"> <span>ACIVICIN [USAN]</span> </td> <td> <info-popup> <div class="info-popup-container"> <div> <label>Source:</label> <referencesmanager reftable hide-header="true" show='["cit"]' substance ="'55be1968-94cc-4e6a-a098-7ebaae1a6645'" sreferences = "[{"id":null,"label":"GInAS Reference","term":"068a0ef8-c824-4f12-adb7-e6e2bdbdd4b0","href":null,"_matchContext":null}]" > </referencesmanager> </div> </div> </info-popup> </td> </tr> </table> </td> <td id="one-line"> Common Name </td> <td > English </td> </tr> <tr> <td> <table class="info-wrapper"> <tr> <td style="width:100%;"> <span>U 42,126</span> </td> <td> <info-popup> <div class="info-popup-container"> <div> <label>Source:</label> <referencesmanager reftable hide-header="true" show='["cit"]' substance ="'55be1968-94cc-4e6a-a098-7ebaae1a6645'" sreferences = "[{"id":null,"label":"GInAS Reference","term":"f1b461c4-fbbd-41aa-b047-d0bf2cae6f45","href":null,"_matchContext":null}]" > </referencesmanager> </div> </div> </info-popup> </td> </tr> </table> </td> <td id="one-line"> Code </td> <td > English </td> </tr> <tr> <td> <table class="info-wrapper"> <tr> <td style="width:100%;"> <span>5-ISOXAZOLEACETIC ACID, .ALPHA.-AMINO-3-CHLORO-4,5-DIHYDRO-, (S-(R*,R*))-</span> </td> <td> <info-popup> <div class="info-popup-container"> <div> <label>Source:</label> <referencesmanager reftable hide-header="true" show='["cit"]' substance ="'55be1968-94cc-4e6a-a098-7ebaae1a6645'" sreferences = "[{"id":null,"label":"GInAS Reference","term":"ca09e9ea-7185-48f9-b178-f0836f13d334","href":null,"_matchContext":null}]" > </referencesmanager> </div> </div> </info-popup> </td> </tr> </table> </td> <td id="one-line"> Systematic Name </td> <td > English </td> </tr> <tr> <td> <table class="info-wrapper"> <tr> <td style="width:100%;"> <span>acivicin [INN]</span> </td> <td> <info-popup> <div class="info-popup-container"> <div> <label>Source:</label> <referencesmanager reftable hide-header="true" show='["cit"]' substance ="'55be1968-94cc-4e6a-a098-7ebaae1a6645'" sreferences = "[{"id":null,"label":"GInAS Reference","term":"33582c0e-7dbd-4c71-9ba9-edba8a31faf9","href":null,"_matchContext":null}]" > </referencesmanager> </div> </div> </info-popup> </td> </tr> </table> </td> <td id="one-line"> Common Name </td> <td > English </td> </tr> <tr> <td> <table class="info-wrapper"> <tr> <td style="width:100%;"> <span>(αS,5S)-α-Amino-3-chloro-2-isoxazoline-5-acetic acid</span> </td> <td> <info-popup> <div class="info-popup-container"> <div> <label>Source:</label> <referencesmanager reftable hide-header="true" show='["cit"]' substance ="'55be1968-94cc-4e6a-a098-7ebaae1a6645'" sreferences = "[{"id":null,"label":"GInAS Reference","term":"ca09e9ea-7185-48f9-b178-f0836f13d334","href":null,"_matchContext":null}]" > </referencesmanager> </div> </div> </info-popup> </td> </tr> </table> </td> <td id="one-line"> Systematic Name </td> <td > English </td> </tr> <tr> <td> <table class="info-wrapper"> <tr> <td style="width:100%;"> <span>AT 125</span> </td> <td> <info-popup> <div class="info-popup-container"> <div> <label>Source:</label> <referencesmanager reftable hide-header="true" show='["cit"]' substance ="'55be1968-94cc-4e6a-a098-7ebaae1a6645'" sreferences = "[{"id":null,"label":"GInAS Reference","term":"f1b461c4-fbbd-41aa-b047-d0bf2cae6f45","href":null,"_matchContext":null}]" > </referencesmanager> </div> </div> </info-popup> </td> </tr> </table> </td> <td id="one-line"> Code </td> <td > English </td> </tr> <tr> <td> <table class="info-wrapper"> <tr> <td style="width:100%;"> <span>ACIVICIN [MART.]</span> </td> <td> <info-popup> <div class="info-popup-container"> <div> <label>Source:</label> <referencesmanager reftable hide-header="true" show='["cit"]' substance ="'55be1968-94cc-4e6a-a098-7ebaae1a6645'" sreferences = "[{"id":null,"label":"GInAS Reference","term":"76b5e183-5f3c-4f84-87ae-03774cb48dad","href":null,"_matchContext":null}]" > </referencesmanager> </div> </div> </info-popup> </td> </tr> </table> </td> <td id="one-line"> Common Name </td> <td > English </td> </tr> <tr> <td> <table class="info-wrapper"> <tr> <td style="width:100%;"> <span>U-42,126</span> </td> <td> <info-popup> <div class="info-popup-container"> <div> <label>Source:</label> <referencesmanager reftable hide-header="true" show='["cit"]' substance ="'55be1968-94cc-4e6a-a098-7ebaae1a6645'" sreferences = "[{"id":null,"label":"GInAS Reference","term":"46df32bd-bfde-479d-aac5-b63830a3a979","href":null,"_matchContext":null}]" > </referencesmanager> </div> </div> </info-popup> </td> </tr> </table> </td> <td id="one-line"> Code </td> <td > English </td> </tr> </tbody> </table> </card> </div> <div ng-cloak class="fade-ng-cloak ng-cloak"> <card eid='classification' card-title='Classification' count='1' audit='audit'> <table class="table gsrs-datatable" id="codesTable"> <thead> <tr> <th>Classification Tree</th> <th>Code System</th> <th>Code</th> </tr> </thead> <tbody> <tr> <td> <table class="info-wrapper"> <tr> <td style="width:100%;"> <tree-view text = '"Pharmacologic Substance[C1909]|Enzyme Inhibitor[C471]|Glutamine Amidotransferase Inhibitor"'></tree-view> </td> <td> <info-popup> <div class="info-popup-container"> <div> <label>Source:</label> </div> <referencesmanager reftable hide-header="true" show='["cit"]' substance ="'55be1968-94cc-4e6a-a098-7ebaae1a6645'" sreferences = "[{"id":null,"label":"GInAS Reference","term":"33e458a1-9eda-7ac8-07c2-1f8b7fe5c429","href":null,"_matchContext":null}]" > </referencesmanager> </div> </info-popup> </td> </tr> </table> </td> <td id="no-word-break"> NCI_THESAURUS </td> <td> <a href="https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2158" target="_blank" uib-tooltip="Click link">C2158</a> <div class="audit-row" ng-if="audit==true"> <div class="audit-content"> Created by <code>admin</code> on <code>Fri Dec 15 15:15:52 GMT 2023</code> , Edited by <code>admin</code> on <code>Fri Dec 15 15:15:52 GMT 2023</code> </div> </div> </td> </tr> </tbody> </table> </card> </div> <div ng-cloak class="fade-ng-cloak ng-cloak"> <card eid='identifiers' card-title='Identifiers' count='13' audit='audit'> <table class="table gsrs-datatable" id="codesTable"> <thead> <tr> <th>Code System</th> <th>Code</th> <th>Type</th> <th>Description</th> </tr> </thead> <tr> <td class="short"> <table class="info-wrapper"> <tr> <td style="width:100%;" id="no-word-break"> <span>CAS</span> </td> <td> <info-popup> <div class="info-popup-container"> <div> <label>Sources:</label> </div> <referencesmanager reftable hide-header="true" show='["cit"]' substance ="'55be1968-94cc-4e6a-a098-7ebaae1a6645'" sreferences = "[{"id":null,"label":"GInAS Reference","term":"d56f39ed-425c-459e-bce4-5c54270ef27d","href":null,"_matchContext":null},{"id":null,"label":"GInAS Reference","term":"ee6a8d9c-143d-42e5-920d-d9c5982c95cf","href":null,"_matchContext":null}]" > </referencesmanager> </div> </info-popup> </td> </tr> </table> </td> <td id="one-line"> <a href="https://commonchemistry.cas.org/detail?cas_rn=42228-92-2" target="_blank" title="https://commonchemistry.cas.org/detail?cas_rn=42228-92-2">42228-92-2</a> <div class="audit-row" ng-if="audit==true"> <div class="audit-content"> Created by <code>admin</code> on <code>Fri Dec 15 15:15:52 GMT 2023</code> , Edited by <code>admin</code> on <code>Fri Dec 15 15:15:52 GMT 2023</code> </div> </div> </td> <td id="one-line"> PRIMARY </td> <td> </td> <tr> <td class="short"> <table class="info-wrapper"> <tr> <td style="width:100%;" id="no-word-break"> <span>PUBCHEM</span> </td> <td> <info-popup> <div class="info-popup-container"> <div> <label>Source:</label> </div> <referencesmanager reftable hide-header="true" show='["cit"]' substance ="'55be1968-94cc-4e6a-a098-7ebaae1a6645'" sreferences = "[{"id":null,"label":"GInAS Reference","term":"d56f39ed-425c-459e-bce4-5c54270ef27d","href":null,"_matchContext":null}]" > </referencesmanager> </div> </info-popup> </td> </tr> </table> </td> <td id="one-line"> <a href="https://pubchem.ncbi.nlm.nih.gov/compound/294641" target="_blank" title="https://pubchem.ncbi.nlm.nih.gov/compound/294641">294641</a> <div class="audit-row" ng-if="audit==true"> <div class="audit-content"> Created by <code>admin</code> on <code>Fri Dec 15 15:15:52 GMT 2023</code> , Edited by <code>admin</code> on <code>Fri Dec 15 15:15:52 GMT 2023</code> </div> </div> </td> <td id="one-line"> PRIMARY </td> <td> </td> <tr> <td class="short"> <table class="info-wrapper"> <tr> <td style="width:100%;" id="no-word-break"> <span>MESH</span> </td> <td> <info-popup> <div class="info-popup-container"> <div> <label>Source:</label> </div> <referencesmanager reftable hide-header="true" show='["cit"]' substance ="'55be1968-94cc-4e6a-a098-7ebaae1a6645'" sreferences = "[{"id":null,"label":"GInAS Reference","term":"d56f39ed-425c-459e-bce4-5c54270ef27d","href":null,"_matchContext":null}]" > </referencesmanager> </div> </info-popup> </td> </tr> </table> </td> <td id="one-line"> <a href="http://www.ncbi.nlm.nih.gov/mesh/67006303" target="_blank" title="http://www.ncbi.nlm.nih.gov/mesh/67006303">C006303</a> <div class="audit-row" ng-if="audit==true"> <div class="audit-content"> Created by <code>admin</code> on <code>Fri Dec 15 15:15:52 GMT 2023</code> , Edited by <code>admin</code> on <code>Fri Dec 15 15:15:52 GMT 2023</code> </div> </div> </td> <td id="one-line"> PRIMARY </td> <td> </td> <tr> <td class="short"> <table class="info-wrapper"> <tr> <td style="width:100%;" id="no-word-break"> <span>EVMPD</span> </td> <td> <info-popup> <div class="info-popup-container"> <div> <label>Source:</label> </div> <referencesmanager reftable hide-header="true" show='["cit"]' substance ="'55be1968-94cc-4e6a-a098-7ebaae1a6645'" sreferences = "[{"id":null,"label":"GInAS Reference","term":"d56f39ed-425c-459e-bce4-5c54270ef27d","href":null,"_matchContext":null}]" > </referencesmanager> </div> </info-popup> </td> </tr> </table> </td> <td id="one-line"> SUB05241MIG <div class="audit-row" ng-if="audit==true"> <div class="audit-content"> Created by <code>admin</code> on <code>Fri Dec 15 15:15:52 GMT 2023</code> , Edited by <code>admin</code> on <code>Fri Dec 15 15:15:52 GMT 2023</code> </div> </div> </td> <td id="one-line"> PRIMARY </td> <td> </td> <tr> <td class="short"> <table class="info-wrapper"> <tr> <td style="width:100%;" id="no-word-break"> <span>WIKIPEDIA</span> </td> <td> <info-popup> <div class="info-popup-container"> <div> <label>Source:</label> </div> <referencesmanager reftable hide-header="true" show='["cit"]' substance ="'55be1968-94cc-4e6a-a098-7ebaae1a6645'" sreferences = "[{"id":null,"label":"GInAS Reference","term":"d56f39ed-425c-459e-bce4-5c54270ef27d","href":null,"_matchContext":null}]" > </referencesmanager> </div> </info-popup> </td> </tr> </table> </td> <td id="one-line"> <a href="https://en.wikipedia.org/wiki/Acivicin" target="_blank" title="https://en.wikipedia.org/wiki/Acivicin">ACIVICIN</a> <div class="audit-row" ng-if="audit==true"> <div class="audit-content"> Created by <code>admin</code> on <code>Fri Dec 15 15:15:52 GMT 2023</code> , Edited by <code>admin</code> on <code>Fri Dec 15 15:15:52 GMT 2023</code> </div> </div> </td> <td id="one-line"> PRIMARY </td> <td> </td> <tr> <td class="short"> <table class="info-wrapper"> <tr> <td style="width:100%;" id="no-word-break"> <span>ChEMBL</span> </td> <td> <info-popup> <div class="info-popup-container"> <div> <label>Source:</label> </div> <referencesmanager reftable hide-header="true" show='["cit"]' substance ="'55be1968-94cc-4e6a-a098-7ebaae1a6645'" sreferences = "[{"id":null,"label":"GInAS Reference","term":"d56f39ed-425c-459e-bce4-5c54270ef27d","href":null,"_matchContext":null}]" > </referencesmanager> </div> </info-popup> </td> </tr> </table> </td> <td id="one-line"> <a href="https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1231101" target="_blank" title="https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1231101">CHEMBL1231101</a> <div class="audit-row" ng-if="audit==true"> <div class="audit-content"> Created by <code>admin</code> on <code>Fri Dec 15 15:15:52 GMT 2023</code> , Edited by <code>admin</code> on <code>Fri Dec 15 15:15:52 GMT 2023</code> </div> </div> </td> <td id="one-line"> PRIMARY </td> <td> </td> <tr> <td class="short"> <table class="info-wrapper"> <tr> <td style="width:100%;" id="no-word-break"> <span>EPA CompTox</span> </td> <td> <info-popup> <div class="info-popup-container"> <div> <label>Source:</label> </div> <referencesmanager reftable hide-header="true" show='["cit"]' substance ="'55be1968-94cc-4e6a-a098-7ebaae1a6645'" sreferences = "[{"id":null,"label":"GInAS Reference","term":"88de2002-eac1-ed0b-b3a8-0318c8e83b1b","href":null,"_matchContext":null}]" > </referencesmanager> </div> </info-popup> </td> </tr> </table> </td> <td id="one-line"> <a href="https://comptox.epa.gov/dashboard/chemical/details/DTXSID0046010" target="_blank" title="https://comptox.epa.gov/dashboard/chemical/details/DTXSID0046010">DTXSID0046010</a> <div class="audit-row" ng-if="audit==true"> <div class="audit-content"> Created by <code>admin</code> on <code>Fri Dec 15 15:15:52 GMT 2023</code> , Edited by <code>admin</code> on <code>Fri Dec 15 15:15:52 GMT 2023</code> </div> </div> </td> <td id="one-line"> PRIMARY </td> <td> </td> <tr> <td class="short"> <table class="info-wrapper"> <tr> <td style="width:100%;" id="no-word-break"> <span>CHEBI</span> </td> <td> <info-popup> <div class="info-popup-container"> <div> <label>Source:</label> </div> <referencesmanager reftable hide-header="true" show='["cit"]' substance ="'55be1968-94cc-4e6a-a098-7ebaae1a6645'" sreferences = "[{"id":null,"label":"GInAS Reference","term":"33e458a1-9eda-7ac8-07c2-1f8b7fe5c429","href":null,"_matchContext":null}]" > </referencesmanager> </div> </info-popup> </td> </tr> </table> </td> <td id="one-line"> <a href="https://www.ebi.ac.uk/chebi/chebiOntology.do?chebiId=CHEBI:74545" target="_blank" title="https://www.ebi.ac.uk/chebi/chebiOntology.do?chebiId=CHEBI:74545">74545</a> <div class="audit-row" ng-if="audit==true"> <div class="audit-content"> Created by <code>admin</code> on <code>Fri Dec 15 15:15:52 GMT 2023</code> , Edited by <code>admin</code> on <code>Fri Dec 15 15:15:52 GMT 2023</code> </div> </div> </td> <td id="one-line"> PRIMARY </td> <td> </td> <tr> <td class="short"> <table class="info-wrapper"> <tr> <td style="width:100%;" id="no-word-break"> <span>NCI_THESAURUS</span> </td> <td> <info-popup> <div class="info-popup-container"> <div> <label>Source:</label> </div> <referencesmanager reftable hide-header="true" show='["cit"]' substance ="'55be1968-94cc-4e6a-a098-7ebaae1a6645'" sreferences = "[{"id":null,"label":"GInAS Reference","term":"d56f39ed-425c-459e-bce4-5c54270ef27d","href":null,"_matchContext":null}]" > </referencesmanager> </div> </info-popup> </td> </tr> </table> </td> <td id="one-line"> <a href="https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C986" target="_blank" title="https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C986">C986</a> <div class="audit-row" ng-if="audit==true"> <div class="audit-content"> Created by <code>admin</code> on <code>Fri Dec 15 15:15:52 GMT 2023</code> , Edited by <code>admin</code> on <code>Fri Dec 15 15:15:52 GMT 2023</code> </div> </div> </td> <td id="one-line"> PRIMARY </td> <td> </td> <tr> <td class="short"> <table class="info-wrapper"> <tr> <td style="width:100%;" id="no-word-break"> <span>SMS_ID</span> </td> <td> <info-popup> <div class="info-popup-container"> <div> <label>Source:</label> </div> <referencesmanager reftable hide-header="true" show='["cit"]' substance ="'55be1968-94cc-4e6a-a098-7ebaae1a6645'" sreferences = "[{"id":null,"label":"GInAS Reference","term":"e9242888-4afd-63b6-a33c-77e895670571","href":null,"_matchContext":null}]" > </referencesmanager> </div> </info-popup> </td> </tr> </table> </td> <td id="one-line"> 100000084624 <div class="audit-row" ng-if="audit==true"> <div class="audit-content"> Created by <code>admin</code> on <code>Fri Dec 15 15:15:52 GMT 2023</code> , Edited by <code>admin</code> on <code>Fri Dec 15 15:15:52 GMT 2023</code> </div> </div> </td> <td id="one-line"> PRIMARY </td> <td> </td> <tr> <td class="short"> <table class="info-wrapper"> <tr> <td style="width:100%;" id="no-word-break"> <span>NSC</span> </td> <td> <info-popup> <div class="info-popup-container"> <div> <label>Source:</label> </div> <referencesmanager reftable hide-header="true" show='["cit"]' substance ="'55be1968-94cc-4e6a-a098-7ebaae1a6645'" sreferences = "[{"id":null,"label":"GInAS Reference","term":"4aac2374-e47b-d742-137c-c00dad7cf105","href":null,"_matchContext":null}]" > </referencesmanager> </div> </info-popup> </td> </tr> </table> </td> <td id="one-line"> <a href="https://dtp.cancer.gov/dtpstandard/servlet/dwindex?searchtype=NSC&outputformat=html&searchlist=163501" target="_blank" title="https://dtp.cancer.gov/dtpstandard/servlet/dwindex?searchtype=NSC&outputformat=html&searchlist=163501">163501</a> <div class="audit-row" ng-if="audit==true"> <div class="audit-content"> Created by <code>admin</code> on <code>Fri Dec 15 15:15:52 GMT 2023</code> , Edited by <code>admin</code> on <code>Fri Dec 15 15:15:52 GMT 2023</code> </div> </div> </td> <td id="one-line"> PRIMARY </td> <td> </td> <tr> <td class="short"> <table class="info-wrapper"> <tr> <td style="width:100%;" id="no-word-break"> <span>INN</span> </td> <td> <info-popup> <div class="info-popup-container"> <div> <label>Source:</label> </div> <referencesmanager reftable hide-header="true" show='["cit"]' substance ="'55be1968-94cc-4e6a-a098-7ebaae1a6645'" sreferences = "[{"id":null,"label":"GInAS Reference","term":"d56f39ed-425c-459e-bce4-5c54270ef27d","href":null,"_matchContext":null}]" > </referencesmanager> </div> </info-popup> </td> </tr> </table> </td> <td id="one-line"> <a href="https://extranet.who.int/soinn/mod/page/view.php?id=137&inn_n=4858" target="_blank" title="https://extranet.who.int/soinn/mod/page/view.php?id=137&inn_n=4858">4858</a> <div class="audit-row" ng-if="audit==true"> <div class="audit-content"> Created by <code>admin</code> on <code>Fri Dec 15 15:15:52 GMT 2023</code> , Edited by <code>admin</code> on <code>Fri Dec 15 15:15:52 GMT 2023</code> </div> </div> </td> <td id="one-line"> PRIMARY </td> <td> </td> <tr> <td class="short"> <table class="info-wrapper"> <tr> <td style="width:100%;" id="no-word-break"> <span>FDA UNII</span> </td> <td> </td> </tr> </table> </td> <td id="one-line"> O0X60K76I6 <div class="audit-row" ng-if="audit==true"> <div class="audit-content"> Created by <code>admin</code> on <code>Fri Dec 15 15:15:52 GMT 2023</code> , Edited by <code>admin</code> on <code>Fri Dec 15 15:15:52 GMT 2023</code> </div> </div> </td> <td id="one-line"> PRIMARY </td> <td> </td> </table> </card> </div> <div ng-cloak class="fade-ng-cloak ng-cloak"> <card eid='activemoieties' card-title='Active Moiety' count='1' audit='audit'> <table class="table gsrs-datatable"> <thead> <tr> <th>Related Record</th> <th>Type</th> <th>Details</th> </tr> </thead> <tr> <td> <table class="info-wrapper"> <tr> <td style="width:100%;"> <div class="text-center thumb-col"> <div> <code> <a href="/substance/O0X60K76I6" target="_self">O0X60K76I6</a> </code> </div> <img style="width:150px;" class="struc-thumb img-responsive subref" alt="Structure of ACIVICIN" title="Structure of ACIVICIN" src='/img/55be1968-94cc-4e6a-a098-7ebaae1a6645.svg'> <div> <a href="/substance/O0X60K76I6" target="_self">ACIVICIN</a> </div> </div> </td> <td> </td> </tr> </table> </td> <td id="one-line"> ACTIVE MOIETY </td> <td> </td> </tr> </table> </card> </div> <div class="bottom-padding"> </div> </div> </div> <mol-export></mol-export> </div> <script> $(document).ready(function(){ try{ $("table.gsrs-datatable").DataTable( { "lengthMenu": [[5, 20, 100, -1], [5, 20, 100, "All"]], language: { search: "", searchPlaceholder: "Search..." }, "aaSorting": [], "scrollX": true }); }catch(e){ console.log(e); } $('.unloaded').removeClass("unloaded"); $('body').scrollspy({ offset:300, target:".sidebar-inner" }); $('#affix').affix({ offset: { top: 50 } }); $(".dataTables_filter input").addClass("form-control"); }); var onResize = function() { // apply dynamic padding at the top of the body according to the fixed navbar height $("body").css("padding-top", $(".navbar-fixed-top").height()); }; // attach the function to the window resize event $(window).resize(onResize); // call it also when the page is ready after load or reload $(function() { onResize(); }); </script> <script> var hmenu = document.getElementById("h-menu"); var hmenuOffset = hmenu.offsetTop; var hmenuHeight = hmenu.offsetHeight; var hmenuButtonWrap = document.getElementById("hmenu-butt-wrap"); var liSearchWrap = document.getElementById("hmenu-li-search-wrap"); window.onscroll = function() { fixHMenu(); } function fixHMenu() { if(hmenuOffset != null) { // check the offse of the page compared to the horizontal menu if (window.pageYOffset >= hmenuOffset) { // if scrolled past the hmenu, then fix the menu to the top // and show the search bar in it hmenu.classList.add("fix2top"); $("#h-menu #menubar").show(); // now we want to ensure that visibility of the menu buttons // and that of hmenu's search bar is always opposite on small screens if(liSearchWrap.classList.contains("hidden-sm")){ hmenuButtonWrap.classList.remove("hidden-sm", "hidden-xs"); } else { hmenuButtonWrap.classList.add("hidden-sm", "hidden-xs"); } } else { // if we haven't scrolled past the h menu, then do not fix it to top hmenu.classList.remove("fix2top"); $("#h-menu #menubar").hide(); // ensure hmenu's buttons are visible all the time when it's not on top hmenuButtonWrap.classList.remove("hidden-sm", "hidden-xs"); } } } </script> <script> $(function () { if($('.fixedpos').length>0){ var fixmeTop = $('.fixedpos').offset().top; // get initial position of the element $(window).scroll(function() { // assign scroll event listener var currentScroll = $(window).scrollTop(); // get current position if (currentScroll >= fixmeTop-100) { // apply position: fixed if you $('.fixedpos').css({ // scroll to that element or below it position: 'fixed', top: 70 }); } else { // apply position: static $('.fixedpos').css({ // if you scroll above it position: 'absolute', top: 'inherit' }); } }); } var resetBindings = function(){ $('[data-toggle="popover"]:not(.toggle-force)').off(); $('.toggle-on').off(); $('[data-toggle="popover"]:not(.toggle-on)').unbind( "click" ); $('.toggle-on').unbind( "click" ); $('[data-toggle="popover"]:not(.toggle-on)').click(function(){ $(this).addClass("toggle-on"); var _this=this; console.log("not toggle on"); setTimeout(function(){ $(_this).popover("show"); },10); resetBindings(); }); $('.toggle-on').click(function(){ $(this).removeClass("toggle-on"); $(this).popover('hide'); resetBindings(); }); $('[data-toggle="popover"]:not(.toggle-force)') .popover({ trigger: "manual" , html: true, animation:false}) .on("mouseenter", function () { if(false){ var _this = this; var t=Math.random() + ""; $(_this).attr("fade_id",t); $(this).popover("show"); $(".popover").on("mouseleave", function () { setTimeout(function () { if(!$(_this).hasClass("toggle-on")){ $(_this).popover('hide'); } },800); }); } }) .on("mouseleave", function () { if(false){ var _this = this; if(!$(_this).hasClass("toggle-on")){ var t=Math.random() + ""; $(_this).attr("fade_id",t); setTimeout(function () { if (!$(".popover:hover").length) { if($(_this).attr("fade_id") == t){ $(_this).popover("hide"); } } }, 800); } } }); }; resetBindings(); document.body.addEventListener("click", function(e){ if(!$(e.target).parents(".popover").length){ $('[data-toggle="popover"]').popover('hide'); } }); }); </script> <div class="modal export" id="loading"> <div class="modal-dialog"> <div class="modal-content"> <div class="modal-body"> <div id="loading-progress"></div> </div> </div> </div> </div> <div class="inxight-footer"> <div class="container"> <div class="item"><a target="_blank" href="https://www.nih.gov/">NIH</a></div> <div class="item"><a target="_blank" href="https://ncats.nih.gov/">NCATS</a></div> <div class="item"><a target="_blank" href="https://ncats.nih.gov/privacy">PRIVACY ACT</a></div> <div class="item"><a target="_blank" href="https://ncats.nih.gov/accessibility">ACCESSIBILITY</a></div> <div class="item-last"> <a target="_blank" href="/disclaimer"> DISCLAIMER </a> </div> <div class="row"> <div class="item-last"> <a target="_blank" href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html"> HHS VULNERABILITY DISCLOSURE </a> </div> </div> <div class="statement"> <div class="statement-desktop"> For <a href="http://edi.nih.gov/consulting/language-access-program/about" target="_blank" title="Read the plan">language access</a> assistance, contact the <a href="mailto:info@ncats.nih.gov" title="Email Public Information Officer">NCATS Public Information Officer</a> <br> </div> <div> National Center for Advancing Translational Sciences (NCATS), <span class="mobile-statement-break"><br></span> 6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966 </div> </div> </div> <div class=" hidden-xs hidden-sm" id="version"> <code uib-tooltip="Built on Mon Mar 31 19:07:05 GMT 2025 (commit: cb321d54b)" tooltip-placement="auto" tooltip-append-to-body="true"> <small>version 1.1</small> </code> </div> </div> </body> </html>

CINXE.COM

ACIVICIN