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user-links-collapsible-item"><a data-mw="interface" href="https://donate.wikimedia.org/?utm_source=donate&utm_medium=sidebar&utm_campaign=spontaneous&uselang=sr" class=""><span>Донације</span></a> </li> <li id="pt-createaccount-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=%D0%9F%D0%BE%D1%81%D0%B5%D0%B1%D0%BD%D0%BE:%D0%9E%D1%82%D0%B2%D0%BE%D1%80%D0%B8_%D0%BD%D0%B0%D0%BB%D0%BE%D0%B3&returnto=Enzimska+kataliza" title="Иако није обавезно, препоручујемо да отворите налог и пријавите се" class=""><span>Отвори налог</span></a> </li> <li id="pt-login-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=%D0%9F%D0%BE%D1%81%D0%B5%D0%B1%D0%BD%D0%BE:%D0%9A%D0%BE%D1%80%D0%B8%D1%81%D0%BD%D0%B8%D1%87%D0%BA%D0%B0_%D0%BF%D1%80%D0%B8%D1%98%D0%B0%D0%B2%D0%B0&returnto=Enzimska+kataliza" title="Иако није обавезно, препоручујемо да се пријавите [o]" 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href=\"/wiki/%D0%92%D0%B8%D0%BA%D0%B8%D0%BF%D0%B5%D0%B4%D0%B8%D1%98%D0%B0:%D0%90%D0%BA%D1%86%D0%B8%D1%98%D0%B0_%D0%BF%D1%80%D0%BE%D1%88%D0%B8%D1%80%D0%B8%D0%B2%D0%B0%D1%9A%D0%B0_%D0%BA%D0%BB%D0%B8%D1%86%D0%B0\" title=\"Википедија:Акција проширивања клица\"\u003Eакцији проширивања клица\u003C/a\u003E\u003C/b\u003E.\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E";}}());</script></div> </div> <div class="vector-column-start"> <div class="vector-main-menu-container"> <div id="mw-navigation"> <nav id="mw-panel" class="vector-main-menu-landmark" aria-label="Сајт"> <div id="vector-main-menu-pinned-container" class="vector-pinned-container"> </div> </nav> </div> </div> <div class="vector-sticky-pinned-container"> <nav id="mw-panel-toc" aria-label="Садржај" data-event-name="ui.sidebar-toc" class="mw-table-of-contents-container vector-toc-landmark"> <div id="vector-toc-pinned-container" class="vector-pinned-container"> <div id="vector-toc" class="vector-toc vector-pinnable-element"> <div class="vector-pinnable-header vector-toc-pinnable-header vector-pinnable-header-pinned" data-feature-name="toc-pinned" data-pinnable-element-id="vector-toc" > <h2 class="vector-pinnable-header-label">Садржај</h2> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-toc.pin">помери на страну</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-toc.unpin">сакриј</button> </div> <ul class="vector-toc-contents" id="mw-panel-toc-list"> <li id="toc-mw-content-text" class="vector-toc-list-item vector-toc-level-1"> <a href="#" class="vector-toc-link"> <div class="vector-toc-text">Почетак</div> </a> </li> <li id="toc-Indukovano_prilagođavanje" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Indukovano_prilagođavanje"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>Indukovano prilagođavanje</span> </div> </a> <button aria-controls="toc-Indukovano_prilagođavanje-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Садржај одељка Indukovano prilagođavanje</span> </button> <ul id="toc-Indukovano_prilagođavanje-sublist" class="vector-toc-list"> <li id="toc-Kataliza_indukovanim_prilagođavanjem" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Kataliza_indukovanim_prilagođavanjem"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.1</span> <span>Kataliza indukovanim prilagođavanjem</span> </div> </a> <ul id="toc-Kataliza_indukovanim_prilagođavanjem-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Reference" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Reference"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Reference</span> </div> </a> <ul id="toc-Reference-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Literatura" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Literatura"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Literatura</span> </div> </a> <ul id="toc-Literatura-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Vidi_još" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Vidi_još"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Vidi još</span> </div> </a> <ul id="toc-Vidi_još-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main 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class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Enzimska kataliza</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Чланак на другим језицима. Доступан на: 25" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-25" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">25 језика</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%A5%D9%86%D8%B2%D9%8A%D9%85_%D9%85%D8%AD%D9%81%D8%B2" title="إنزيم محفز — арапски" lang="ar" hreflang="ar" data-title="إنزيم محفز" data-language-autonym="العربية" data-language-local-name="арапски" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Katalisis_enzim" title="Katalisis enzim — индонежански" lang="id" hreflang="id" data-title="Katalisis enzim" data-language-autonym="Bahasa Indonesia" data-language-local-name="индонежански" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-bn mw-list-item"><a href="https://bn.wikipedia.org/wiki/%E0%A6%89%E0%A7%8E%E0%A6%B8%E0%A7%87%E0%A6%9A%E0%A6%95_%E0%A6%85%E0%A6%A8%E0%A7%81%E0%A6%98%E0%A6%9F%E0%A6%A8" title="উৎসেচক অনুঘটন — бенгалски" lang="bn" hreflang="bn" data-title="উৎসেচক অনুঘটন" data-language-autonym="বাংলা" data-language-local-name="бенгалски" class="interlanguage-link-target"><span>বাংলা</span></a></li><li class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/Enzimska_kataliza" title="Enzimska kataliza — босански" lang="bs" hreflang="bs" data-title="Enzimska kataliza" data-language-autonym="Bosanski" data-language-local-name="босански" class="interlanguage-link-target"><span>Bosanski</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Cat%C3%A0lisi_enzim%C3%A0tica" title="Catàlisi enzimàtica — каталонски" lang="ca" hreflang="ca" data-title="Catàlisi enzimàtica" data-language-autonym="Català" data-language-local-name="каталонски" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-da mw-list-item"><a href="https://da.wikipedia.org/wiki/Enzymkatalyse" title="Enzymkatalyse — дански" lang="da" hreflang="da" data-title="Enzymkatalyse" data-language-autonym="Dansk" data-language-local-name="дански" class="interlanguage-link-target"><span>Dansk</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Enzyme_catalysis" title="Enzyme catalysis — енглески" lang="en" hreflang="en" data-title="Enzyme catalysis" data-language-autonym="English" data-language-local-name="енглески" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Cat%C3%A1lisis_enzim%C3%A1tica" title="Catálisis enzimática — шпански" lang="es" hreflang="es" data-title="Catálisis enzimática" data-language-autonym="Español" data-language-local-name="шпански" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%DA%A9%D8%A7%D8%AA%D8%A7%D9%84%DB%8C%D8%B2_%D8%A2%D9%86%D8%B2%DB%8C%D9%85" title="کاتالیز آنزیم — персијски" lang="fa" hreflang="fa" data-title="کاتالیز آنزیم" data-language-autonym="فارسی" data-language-local-name="персијски" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Catalyse_enzymatique" title="Catalyse enzymatique — француски" lang="fr" hreflang="fr" data-title="Catalyse enzymatique" data-language-autonym="Français" data-language-local-name="француски" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Cat%C3%A1lise_encim%C3%A1tica" title="Catálise encimática — галицијски" lang="gl" hreflang="gl" data-title="Catálise encimática" data-language-autonym="Galego" data-language-local-name="галицијски" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Catalisi_enzimatica" title="Catalisi enzimatica — италијански" lang="it" hreflang="it" data-title="Catalisi enzimatica" data-language-autonym="Italiano" data-language-local-name="италијански" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E9%85%B5%E7%B4%A0%E5%8F%8D%E5%BF%9C" title="酵素反応 — јапански" lang="ja" hreflang="ja" data-title="酵素反応" data-language-autonym="日本語" data-language-local-name="јапански" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%ED%9A%A8%EC%86%8C_%EC%B4%89%EB%A7%A4%EC%9E%91%EC%9A%A9" title="효소 촉매작용 — корејски" lang="ko" hreflang="ko" data-title="효소 촉매작용" data-language-autonym="한국어" data-language-local-name="корејски" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-mk mw-list-item"><a href="https://mk.wikipedia.org/wiki/%D0%95%D0%BD%D0%B7%D0%B8%D0%BC%D1%81%D0%BA%D0%B0_%D0%BA%D0%B0%D1%82%D0%B0%D0%BB%D0%B8%D0%B7%D0%B0" title="Ензимска катализа — македонски" lang="mk" hreflang="mk" data-title="Ензимска катализа" data-language-autonym="Македонски" data-language-local-name="македонски" class="interlanguage-link-target"><span>Македонски</span></a></li><li class="interlanguage-link interwiki-mn mw-list-item"><a href="https://mn.wikipedia.org/wiki/%D0%AD%D0%BD%D0%B7%D0%B8%D0%BC%D0%B8%D0%B9%D0%BD_%D0%BA%D0%B0%D1%82%D0%B0%D0%BB%D0%B8%D0%B7" title="Энзимийн катализ — монголски" lang="mn" hreflang="mn" data-title="Энзимийн катализ" data-language-autonym="Монгол" data-language-local-name="монголски" class="interlanguage-link-target"><span>Монгол</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Enzymatische_katalyse" title="Enzymatische katalyse — холандски" lang="nl" hreflang="nl" data-title="Enzymatische katalyse" data-language-autonym="Nederlands" data-language-local-name="холандски" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Cat%C3%A1lise_enzim%C3%A1tica" title="Catálise enzimática — португалски" lang="pt" hreflang="pt" data-title="Catálise enzimática" data-language-autonym="Português" data-language-local-name="португалски" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ps mw-list-item"><a href="https://ps.wikipedia.org/wiki/%D8%A7%D9%86%D8%B2%D8%A7%DB%8C%D9%85%D9%8A_%DA%A9%D8%A7%D9%BC%D8%A7%D9%84%DB%8C%D8%B2" title="انزایمي کاټالیز — паштунски" lang="ps" hreflang="ps" data-title="انزایمي کاټالیز" data-language-autonym="پښتو" data-language-local-name="паштунски" class="interlanguage-link-target"><span>پښتو</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%A4%D0%B5%D1%80%D0%BC%D0%B5%D0%BD%D1%82%D0%B0%D1%82%D0%B8%D0%B2%D0%BD%D1%8B%D0%B9_%D0%BA%D0%B0%D1%82%D0%B0%D0%BB%D0%B8%D0%B7" title="Ферментативный катализ — руски" lang="ru" hreflang="ru" data-title="Ферментативный катализ" data-language-autonym="Русский" data-language-local-name="руски" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Enzimska_kataliza" title="Enzimska kataliza — српскохрватски" lang="sh" hreflang="sh" data-title="Enzimska kataliza" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="српскохрватски" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/X%C3%BAc_t%C3%A1c_enzym" title="Xúc tác enzym — вијетнамски" lang="vi" hreflang="vi" data-title="Xúc tác enzym" data-language-autonym="Tiếng Việt" data-language-local-name="вијетнамски" class="interlanguage-link-target"><span>Tiếng Việt</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Enzim_katalizi" title="Enzim katalizi — турски" lang="tr" hreflang="tr" data-title="Enzim katalizi" data-language-autonym="Türkçe" data-language-local-name="турски" class="interlanguage-link-target"><span>Türkçe</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%A4%D0%B5%D1%80%D0%BC%D0%B5%D0%BD%D1%82%D0%B0%D1%82%D0%B8%D0%B2%D0%BD%D0%B8%D0%B9_%D0%BA%D0%B0%D1%82%D0%B0%D0%BB%D1%96%D0%B7" title="Ферментативний каталіз — украјински" lang="uk" hreflang="uk" data-title="Ферментативний каталіз" data-language-autonym="Українська" data-language-local-name="украјински" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E9%85%B6%E4%BF%83%E5%8F%8D%E5%BA%94" title="酶促反应 — кинески" lang="zh" hreflang="zh" data-title="酶促反应" data-language-autonym="中文" data-language-local-name="кинески" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span 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href="/w/index.php?title=%D0%9F%D0%BE%D1%81%D0%B5%D0%B1%D0%BD%D0%BE:DownloadAsPdf&page=Enzimska_kataliza&action=show-download-screen"><span>Преузми у PDF-у</span></a></li><li id="t-print" class="mw-list-item"><a href="javascript:print();" rel="alternate" title="Одштампајте ову страницу [p]" accesskey="p"><span>Одштампај</span></a></li> </ul> </div> </div> <div id="p-wikibase-otherprojects" class="vector-menu mw-portlet mw-portlet-wikibase-otherprojects" > <div class="vector-menu-heading"> На другим пројектима </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="wb-otherproject-link wb-otherproject-commons mw-list-item"><a href="https://commons.wikimedia.org/wiki/Category:Enzyme_catalysis" hreflang="en"><span>Викиостава</span></a></li><li id="t-wikibase" class="wb-otherproject-link wb-otherproject-wikibase-dataitem mw-list-item"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q2941663" title="Веза ка ставци на спремишту података [g]" accesskey="g"><span>Ставка на Википодацима</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> </div> </div> </div> <div class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="Алатке странице"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Изглед"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Изглед</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">помери на страну</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">сакриј</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">С Википедије, слободне енциклопедије</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="sr" dir="ltr"><p><b>Enzimska kataliza</b> je <a href="/wiki/%D0%9A%D0%B0%D1%82%D0%B0%D0%BB%D0%B8%D0%B7%D0%B0" title="Катализа">kataliza</a> <a href="/wiki/%D0%A5%D0%B5%D0%BC%D0%B8%D1%98%D1%81%D0%BA%D0%B5_%D1%80%D0%B5%D0%B0%D0%BA%D1%86%D0%B8%D1%98%D0%B5" class="mw-redirect" title="Хемијске реакције">hemijske reakcije</a> posredstvom specijalizovanih <a href="/wiki/%D0%9F%D1%80%D0%BE%D1%82%D0%B5%D0%B8%D0%BD" title="Протеин">proteina</a>, <a href="/wiki/%D0%95%D0%BD%D0%B7%D0%B8%D0%BC" title="Ензим">enzima</a>. Kataliza <a href="/wiki/%D0%91%D0%B8%D0%BE%D1%85%D0%B5%D0%BC%D0%B8%D1%98%D0%B0" title="Биохемија">biohemijskih</a> reakcija u <a href="/wiki/%D0%8B%D0%B5%D0%BB%D0%B8%D1%98%D0%B0_(%D0%B1%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%98%D0%B0)" title="Ћелија (биологија)">ćeliji</a> je vitalna zbog veoma niskih reakcionih brzina nekatalisanih reakcija. </p><p>Mehanizam enzimaske katalize je sličan u principu sa drugim tipovima <a href="/wiki/%D0%9A%D0%B0%D1%82%D0%B0%D0%BB%D0%B8%D0%B7%D0%B0" title="Катализа">hemijske katalize</a>. Putem pružanja alternativnog reakcionog puta i stabilizacijom intermedijera enzim redukuje energiju koje je neophodna da se dostigne najviše energetsko <a href="/wiki/Prelazno_stanje" title="Prelazno stanje">prelazno stanje</a> reakcije. Redukcija energije aktivacije (Ea) povećava broj molekula reaktanta sa dovoljnom energijom da dosegnu energiju aktivacije i formiraju produkt. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Indukovano_prilagođavanje"><span id="Indukovano_prilago.C4.91avanje"></span>Indukovano prilagođavanje</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Enzimska_kataliza&veaction=edit&section=1" title="Уредите одељак „Indukovano prilagođavanje”" class="mw-editsection-visualeditor"><span>уреди</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Enzimska_kataliza&action=edit&section=1" title="Уреди извор одељка: Indukovano prilagođavanje"><span>уреди извор</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-halign-right" typeof="mw:File/Thumb"><a href="/wiki/%D0%94%D0%B0%D1%82%D0%BE%D1%82%D0%B5%D0%BA%D0%B0:Induced_fit_diagram.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/2/24/Induced_fit_diagram.svg/350px-Induced_fit_diagram.svg.png" decoding="async" width="350" height="137" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/24/Induced_fit_diagram.svg/525px-Induced_fit_diagram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/24/Induced_fit_diagram.svg/700px-Induced_fit_diagram.svg.png 2x" data-file-width="648" data-file-height="253" /></a><figcaption>Ilustracija hipoteze indukovanog prilagođavanja enzima</figcaption></figure> <p>Jedan od modela intrerakcije enzima i <a href="/wiki/Supstrat_(biohemija)" class="mw-redirect" title="Supstrat (biohemija)">supstrata</a> je model indukovanog prilagođavanja.<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> Po tom modelu inicijalna interakcija između enzima i supstrata je relativno slaba, ali te slabe interakcije brzo indukuju <a href="/wiki/Konformaciona_promena_proteina" title="Konformaciona promena proteina">konformacione promene</a> enzima koje pojačavaju vezivanje. </p> <div class="mw-heading mw-heading3"><h3 id="Kataliza_indukovanim_prilagođavanjem"><span id="Kataliza_indukovanim_prilago.C4.91avanjem"></span>Kataliza indukovanim prilagođavanjem</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Enzimska_kataliza&veaction=edit&section=2" title="Уредите одељак „Kataliza indukovanim prilagođavanjem”" class="mw-editsection-visualeditor"><span>уреди</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Enzimska_kataliza&action=edit&section=2" title="Уреди извор одељка: Kataliza indukovanim prilagođavanjem"><span>уреди извор</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-halign-left" typeof="mw:File/Thumb"><a href="/wiki/%D0%94%D0%B0%D1%82%D0%BE%D1%82%D0%B5%D0%BA%D0%B0:Enzyme_catalysis_uniform%2Bdifferential_binding.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/b/b8/Enzyme_catalysis_uniform%2Bdifferential_binding.png/200px-Enzyme_catalysis_uniform%2Bdifferential_binding.png" decoding="async" width="200" height="303" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/b8/Enzyme_catalysis_uniform%2Bdifferential_binding.png/300px-Enzyme_catalysis_uniform%2Bdifferential_binding.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/b8/Enzyme_catalysis_uniform%2Bdifferential_binding.png/400px-Enzyme_catalysis_uniform%2Bdifferential_binding.png 2x" data-file-width="610" data-file-height="925" /></a><figcaption>Različiti mehanizmi vezivanja supstrata</figcaption></figure> <p>Prednosti mehanizma indukovanog prilagođavanja su posledica stabilizacionog dejstva jakog enzimskog vezivanja. Postoje dva različita mehanizma vezivanja supstrata: <i>uniformno vezivanje</i>, koje ima jako vezivanje za supstrat, i <i>diferencijalno vezivanje</i>, koji ima jako vezivanje u prelaznom stanju. Stabilizacioni efekat uniformnog vezivanja povećava afinitet vezivanja supstrata i prelaznog stanja, dok diferencijalno vezivanje povećava jedino afinitet vezivanja prelaznog stanja. Enzimi koriste oba mehanizma i evoluciono su izabrani da minimizuju Ea reakcije. Enzimima koji su zasićeni, tj. koji imaju visok afinitet vezivanja za supstrat, neophodano je diferenciono vezivanje da bi se smanjila Ea, dok mali supstrati koji su nevezani za enzime mogu da koriste bilo diferencijalno ili uniformno vezivanje. </p><p>Ti efekti su doveli do toga da većina proteina koristi mehanizam diferencijalnog vezivanja za redukovanje Ea, tako da većina proteina ima visok afinitet za prelazno stanje. Diferencijalno vezivanje se odvija putem mehanizma indukovanog prilagođavanja. Supstrat se prvo slabo veže, zatim enzim menja konformaciju, čime se povećava afinitet za prelazno stanje i dolazi do stabilizacije i sniženja energije aktivacije. </p> <div class="mw-heading mw-heading2"><h2 id="Reference">Reference</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Enzimska_kataliza&veaction=edit&section=3" title="Уредите одељак „Reference”" class="mw-editsection-visualeditor"><span>уреди</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Enzimska_kataliza&action=edit&section=3" title="Уреди извор одељка: Reference"><span>уреди извор</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r28440201">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-1">^</a></b></span> <span class="reference-text"><cite class="citation journal">Koshland DE (1958). <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC335371">„Application of a Theory of Enzyme Specificity to Protein Synthesis”</a>. <i>Proc. Natl. Acad. Sci. U.S.A</i>. <b>44</b> (2): 98—104. <a href="/wiki/Bibcode" title="Bibcode">Bibcode</a>:<a rel="nofollow" class="external text" href="http://adsabs.harvard.edu/abs/1958PNAS...44...98K">1958PNAS...44...98K</a>. <a href="/wiki/PubMed_Central" title="PubMed Central">PMC</a> <span class="plainlinks"><a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC335371">335371</a> <span typeof="mw:File"><span title="Слободан приступ"><img alt="Слободан приступ" src="//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png" decoding="async" width="9" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/14px-Lock-green.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/18px-Lock-green.svg.png 2x" data-file-width="512" data-file-height="813" /></span></span></span>. <a href="/wiki/PMID" title="PMID">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/16590179">16590179</a>. <a href="/wiki/Digitalni_identifikator_objekta" title="Digitalni identifikator objekta">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1073%2Fpnas.44.2.98">10.1073/pnas.44.2.98</a>.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fsr.wikipedia.org%3AEnzimska+kataliza&rft.atitle=Application+of+a+Theory+of+Enzyme+Specificity+to+Protein+Synthesis&rft.au=Koshland+DE&rft.date=1958&rft.genre=article&rft.issue=2&rft.jtitle=Proc.+Natl.+Acad.+Sci.+U.S.A.&rft.pages=98-104&rft.volume=44&rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC335371&rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC335371&rft_id=info%3Abibcode%2F1958PNAS...44...98K&rft_id=info%3Adoi%2F10.1073%2Fpnas.44.2.98&rft_id=info%3Apmid%2F16590179&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="Literatura">Literatura</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Enzimska_kataliza&veaction=edit&section=4" title="Уредите одељак „Literatura”" class="mw-editsection-visualeditor"><span>уреди</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Enzimska_kataliza&action=edit&section=4" title="Уреди извор одељка: Literatura"><span>уреди извор</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r28440192">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin" style=""> <ul><li>Alan Fersht, <i>Structure and Mechanism in Protein Science : A Guide to Enzyme Catalysis and Protein Folding.</i> W. H. Freeman, 1998. <a href="/wiki/Me%C4%91unarodni_standardni_broj_knjige" title="Međunarodni standardni broj knjige">ISBN</a> <a href="/wiki/%D0%9F%D0%BE%D1%81%D0%B5%D0%B1%D0%BD%D0%BE:%D0%A8%D1%82%D0%B0%D0%BC%D0%BF%D0%B0%D0%BD%D0%B8_%D0%B8%D0%B7%D0%B2%D0%BE%D1%80%D0%B8/978-0-7167-3268-6" title="Посебно:Штампани извори/978-0-7167-3268-6">978-0-7167-3268-6</a></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="Vidi_još"><span id="Vidi_jo.C5.A1"></span>Vidi još</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Enzimska_kataliza&veaction=edit&section=5" title="Уредите одељак „Vidi još”" class="mw-editsection-visualeditor"><span>уреди</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Enzimska_kataliza&action=edit&section=5" title="Уреди извор одељка: Vidi još"><span>уреди извор</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Enzimska_analiza" class="mw-redirect" title="Enzimska analiza">Enzimska analiza</a></li> <li><a href="/wiki/%D0%95%D0%BD%D0%B7%D0%B8%D0%BC%D1%81%D0%BA%D0%B0_%D0%BA%D0%B8%D0%BD%D0%B5%D1%82%D0%B8%D0%BA%D0%B0" title="Ензимска кинетика">Enzimska kinetika</a></li> <li><a href="/w/index.php?title=Proteinska_dinamika&action=edit&redlink=1" class="new" title="Proteinska dinamika (страница не постоји)">Proteinska dinamika</a></li> <li><a href="/wiki/%D0%A2%D1%83%D0%BD%D0%B5%D0%BB_%D0%B5%D1%84%D0%B5%D0%BA%D0%B0%D1%82" title="Тунел ефекат">Tunel efekat</a></li></ul> <div style="clear:both;"></div> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r25469611">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output 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href="/wiki/%D0%9F%D0%BE%D1%81%D0%B5%D0%B1%D0%BD%D0%BE:%D0%A3%D1%80%D0%B5%D0%B4%D0%B8_%D1%81%D1%82%D1%80%D0%B0%D0%BD%D0%B8%D1%86%D1%83/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Enzimi-lat" title="Посебно:Уреди страницу/Шаблон:Enzimi-lat"><abbr title="Уредите шаблон" style=";;background:none transparent;color:inherit;border:none;box-shadow:none;padding:0;">у</abbr></a></li></ul></div><div id="Enzimi" style="font-size:114%;margin:0 4em"><a href="/wiki/%D0%95%D0%BD%D0%B7%D0%B8%D0%BC" title="Ензим">Enzimi</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Teme</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Aktivno_mesto" title="Aktivno mesto">Aktivno mesto</a></li> <li><a href="/wiki/Alosterna_regulacija" title="Alosterna regulacija">Alosterna regulacija</a></li> <li><a href="/wiki/Mesto_vezivanja" title="Mesto vezivanja">Mesto vezivanja</a></li> <li><a href="/wiki/Kataliti%C4%8Dki_perfektan_enzim" title="Katalitički perfektan enzim">Katalitički perfektan enzim</a></li> <li><a href="/wiki/Kofaktor_(biohemija)" title="Kofaktor (biohemija)">Koenzim</a></li> <li><a href="/wiki/Kofaktor_(biohemija)" title="Kofaktor (biohemija)">Kofaktor</a></li> <li><a href="/wiki/Kooperativnost_(biohemija)" title="Kooperativnost (biohemija)">Kooperativnost</a></li> <li><a href="/wiki/Klasifikacija_enzima" title="Klasifikacija enzima">EC broj</a></li> <li><a class="mw-selflink selflink">Enzimska kataliza</a></li> <li><a href="/wiki/Inhibitor_enzima" title="Inhibitor enzima">Inhibicija enzima</a></li> <li><a href="/wiki/%D0%95%D0%BD%D0%B7%D0%B8%D0%BC%D1%81%D0%BA%D0%B0_%D0%BA%D0%B8%D0%BD%D0%B5%D1%82%D0%B8%D0%BA%D0%B0" title="Ензимска кинетика">Enzimska kinetika</a></li> <li><a href="/wiki/%D0%9B%D0%B0%D1%98%D0%BD%D0%B2%D0%B8%D0%B2%D0%B5%D1%80%E2%80%94%D0%91%D0%B5%D1%80%D0%BA%D0%BE%D0%B2_%D0%B4%D0%B8%D1%98%D0%B0%D0%B3%D1%80%D0%B0%D0%BC" title="Лајнвивер—Берков дијаграм">Lajnviver—Berkov dijagram</a></li> <li><a href="/wiki/%D0%9C%D0%B8%D1%85%D0%B0%D0%B5%D0%BB%D0%B8%D1%81%E2%80%94%D0%9C%D0%B5%D0%BD%D1%82%D0%B5%D0%BD%D0%B8%D0%BD%D0%B0_%D0%BA%D0%B8%D0%BD%D0%B5%D1%82%D0%B8%D0%BA%D0%B0" title="Михаелис—Ментенина кинетика">Mihaelis—Mentenina kinetika</a></li> <li><a href="/wiki/Spisak_enzima" title="Spisak enzima">Spisak enzima</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Tipovi</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><b>EC1 <a href="/wiki/Oksidoreduktaza" title="Oksidoreduktaza">Oksidoreduktaze</a></b> /<a href="/wiki/Spisak_EC_brojeva_(EC_1)" title="Spisak EC brojeva (EC 1)">spisak</a></li> <li><b>EC2 <a href="/wiki/Transferaza" title="Transferaza">Transferaze</a></b> /<a href="/wiki/Spisak_EC_brojeva_(EC_2)" title="Spisak EC brojeva (EC 2)">spisak</a></li> <li><b>EC3 <a href="/wiki/Hidrolaza" title="Hidrolaza">Hidrolaze</a></b> /<a href="/wiki/Spisak_EC_brojeva_(EC_3)" title="Spisak EC brojeva (EC 3)">spisak</a></li> <li><b>EC4 <a href="/wiki/Lijaza" title="Lijaza">Lijaze</a></b> /<a href="/wiki/Spisak_EC_brojeva_(EC_4)" title="Spisak EC brojeva (EC 4)">spisak</a></li> <li><b>EC5 <a href="/wiki/Izomeraza" title="Izomeraza">Izomeraze</a></b> /<a href="/wiki/Spisak_EC_brojeva_(EC_5)" title="Spisak EC brojeva (EC 5)">spisak</a></li> <li><b>EC6 <a href="/wiki/DNK_ligaza" title="DNK ligaza">Ligaze</a></b> /<a href="/wiki/Spisak_EC_brojeva_(EC_6)" title="Spisak EC brojeva (EC 6)">spisak</a></li></ul> </div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div> <ul><li><i><a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Biohemija_metanavs-lat" title="Шаблон:Biohemija metanavs-lat">B</a> <a href="/wiki/%D0%95%D0%BD%D0%B7%D0%B8%D0%BC" title="Ензим">enzm</a>: <a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Alkoholne_oksidoreduktaze-lat" title="Шаблон:Alkoholne oksidoreduktaze-lat">1.1</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Aldehid/Okso_oksidoreduktaze-lat" title="Шаблон:Aldehid/Okso oksidoreduktaze-lat">2</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:CH-CH_oksidoreduktaze-lat" title="Шаблон:CH-CH oksidoreduktaze-lat">3</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:CH-NH2_oksidoreduktaze-lat" title="Шаблон:CH-NH2 oksidoreduktaze-lat">4</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:CH-NH_oksidoreduktaze-lat" title="Шаблон:CH-NH oksidoreduktaze-lat">5</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:NADH_ili_NADPH_oksidoreduktaze-lat" title="Шаблон:NADH ili NADPH oksidoreduktaze-lat">6</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Azotni_donor_oksidoreduktaze-lat" title="Шаблон:Azotni donor oksidoreduktaze-lat">7</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Sumporne_oksidoreduktaze-lat" title="Шаблон:Sumporne oksidoreduktaze-lat">8</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Difenolna_familija_oksidoreduktaza-lat" title="Шаблон:Difenolna familija oksidoreduktaza-lat">10</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Peroksidaze-lat" title="Шаблон:Peroksidaze-lat">11</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Monooksigenaze-lat" title="Шаблон:Monooksigenaze-lat">13</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Dioksigenaze-lat" title="Шаблон:Dioksigenaze-lat">14</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Druge_oksidoreduktaze-lat" title="Шаблон:Druge oksidoreduktaze-lat">15-18</a>, <a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Jedan_ugljenik_transferaze-lat" class="mw-redirect" title="Шаблон:Jedan ugljenik transferaze-lat">2.1</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Aldehid-keton_transferaze-lat" title="Шаблон:Aldehid-keton transferaze-lat">2</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Aciltransferaze-lat" title="Шаблон:Aciltransferaze-lat">3</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Glikoziltransferaze-lat" title="Шаблон:Glikoziltransferaze-lat">4</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Alkil_i_aril_transferaze-lat" title="Шаблон:Alkil i aril transferaze-lat">5</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Azotne_transferaze-lat" title="Шаблон:Azotne transferaze-lat">6</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Kinaze-lat" title="Шаблон:Kinaze-lat">7</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Sumpor-sadr%C5%BEavaju%C4%87e-grupe_transferaze-lat" class="mw-redirect" title="Шаблон:Sumpor-sadržavajuće-grupe transferaze-lat">8</a>, <a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Tirozinske_kinaze-lat" title="Шаблон:Tirozinske kinaze-lat">2.7.10</a>, <a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Serin/treonin_specifi%C4%8Dne_proteinske_kinaze-lat" class="mw-redirect" title="Шаблон:Serin/treonin specifične proteinske kinaze-lat">2.7.11-12</a>, <a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Esteraze-lat" title="Шаблон:Esteraze-lat">3.1</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:%C5%A0e%C4%87erne_hidrolaze-lat" title="Шаблон:Šećerne hidrolaze-lat">2</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Etarska_veza_hidrolaze-lat" title="Шаблон:Etarska veza hidrolaze-lat">3</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Proteaze-lat" title="Шаблон:Proteaze-lat">4</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Ugljenik-azot_ne-peptidne_hidrolaze-lat" class="mw-redirect" title="Шаблон:Ugljenik-azot ne-peptidne hidrolaze-lat">5</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Hidrolaze_kiselinskih_anhidrida-lat" title="Шаблон:Hidrolaze kiselinskih anhidrida-lat">6</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Ugljenik-ugljenik_hidrolaze-lat" class="mw-redirect" title="Шаблон:Ugljenik-ugljenik hidrolaze-lat">7</a>, <a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Proteinske_tirozinske_fosfataze-lat" title="Шаблон:Proteinske tirozinske fosfataze-lat">3.1.3.48</a>, <a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Serinske_endopeptidaze-lat" title="Шаблон:Serinske endopeptidaze-lat">3.4.21</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Cisteinske_proteaze-lat" title="Шаблон:Cisteinske proteaze-lat">22</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Proteaze_asparaginske_kiseline-lat" class="mw-redirect" title="Шаблон:Proteaze asparaginske kiseline-lat">23</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Metaloendopeptidaze-lat" title="Шаблон:Metaloendopeptidaze-lat">24</a>, <a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Ugljenik-ugljenik_liaze-lat" class="mw-redirect" title="Шаблон:Ugljenik-ugljenik liaze-lat">4.1</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Ugljenik-kiseonik_liaze-lat" class="mw-redirect" title="Шаблон:Ugljenik-kiseonik liaze-lat">2</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Ugljenik-azot_liaze-lat" title="Шаблон:Ugljenik-azot liaze-lat">3</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Ugljenik-sumpor_liaze-lat" class="mw-redirect" title="Шаблон:Ugljenik-sumpor liaze-lat">4</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Ugljenik-halid_liaze-lat" class="mw-redirect" title="Шаблон:Ugljenik-halid liaze-lat">5</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Fosfor-kiseonik_liaze-lat" title="Шаблон:Fosfor-kiseonik liaze-lat">6</a>, <a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Racemaze_i_epimeraze-lat" title="Шаблон:Racemaze i epimeraze-lat">5.1</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Geometrijske_izomeraze-lat" title="Шаблон:Geometrijske izomeraze-lat">2</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Intramolekularne_oksidoreduktaze-lat" title="Шаблон:Intramolekularne oksidoreduktaze-lat">3</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Mutaze-lat" title="Шаблон:Mutaze-lat">4</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Topoizomeraze-lat" title="Шаблон:Topoizomeraze-lat">99</a>, <a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Ligaze_CO_CS_i_CN-lat" title="Шаблон:Ligaze CO CS i CN-lat">6.1-3</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Ugljenik-ugljenik_ligaze-lat" class="mw-redirect" title="Шаблон:Ugljenik-ugljenik ligaze-lat">4</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Fosforni_estar_i_azot-metal_ligaze-lat" title="Шаблон:Fosforni estar i azot-metal ligaze-lat">5-6</a></i></li></ul> </div></td></tr></tbody></table></div> <style data-mw-deduplicate="TemplateStyles:r26481770">.mw-parser-output .portal-bar{font-size:88%;font-weight:bold;display:flex;justify-content:center;align-items:baseline}.mw-parser-output .portal-bar-bordered{padding:0 2em;background-color:#fdfdfd;border:1px solid #a2a9b1;clear:both;margin:1em auto 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